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Tytuł :
2-aminothiazoles in drug discovery: Privileged structures or toxicophores?
Autorzy :
Jakopin Ž; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, SI, 1000, Ljubljana, Slovenia. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Oct 01; Vol. 330, pp. 109244. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery/*methods
Thiazoles/*chemistry
Animals ; Humans ; Structure-Activity Relationship ; Thiazoles/metabolism ; Thiazoles/toxicity
Czasopismo naukowe
Tytuł :
Excitatory effect of acotiamide on rat and human bladder: Implications for underactive bladder treatment.
Autorzy :
Singh N; Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States of America.
Mizoguchi S; Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States of America.
Suzuki T; Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States of America.
Zabbarova I; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.
Ikeda Y; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.
Kanai A; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America.
Chermansky C; Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States of America.
Yoshimura N; Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States of America.
Tyagi P; Department of Urology, University of Pittsburgh, Pittsburgh, PA, United States of America. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118179. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article
MeSH Terms :
Benzamides/*therapeutic use
Thiazoles/*therapeutic use
Urinary Bladder/*pathology
Urinary Bladder, Underactive/*drug therapy
Animals ; Benzamides/chemistry ; Benzamides/pharmacology ; Carbachol/pharmacology ; Electric Stimulation ; Humans ; Male ; Muscle Contraction/drug effects ; Rats, Sprague-Dawley ; Thiazoles/chemistry ; Thiazoles/pharmacology ; Urinary Bladder/drug effects ; Urinary Bladder/innervation
Czasopismo naukowe
Tytuł :
Safety and Tolerability Results from the PILLAR Study: A Phase IV, Double-Blind, Randomized, Placebo-Controlled Study of Mirabegron in Patients ≥ 65 years with Overactive Bladder-Wet.
Autorzy :
Herschorn S; Department of Surgery/Urology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, MG408, Toronto, Ontario, M4N 3M5, Canada. .
Staskin D; Division of Urology, St Elizabeth's Medical Center, 736 Cambridge Street, Brighton, MA, USA.
Schermer CR; Astellas Pharma Global Development, Inc., 1 Astellas Way, Northbrook, IL, 60062, USA.
Kristy RM; Astellas Pharma Global Development, Inc., 1 Astellas Way, Northbrook, IL, 60062, USA.
Wagg A; Department of Medicine, University of Alberta, 1-198 Clinical Sciences Building, 11350 83 Avenue, Edmonton, AB, Canada.
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Źródło :
Drugs & aging [Drugs Aging] 2020 Sep; Vol. 37 (9), pp. 665-676.
Typ publikacji :
Clinical Trial, Phase IV; Journal Article; Randomized Controlled Trial
MeSH Terms :
Acetanilides/*therapeutic use
Adrenergic beta-3 Receptor Agonists/*therapeutic use
Thiazoles/*therapeutic use
Urinary Bladder, Overactive/*drug therapy
Urinary Incontinence/*drug therapy
Acetanilides/administration & dosage ; Acetanilides/adverse effects ; Adrenergic beta-3 Receptor Agonists/administration & dosage ; Adrenergic beta-3 Receptor Agonists/adverse effects ; Age Factors ; Aged ; Diarrhea/chemically induced ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Headache/chemically induced ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Thiazoles/administration & dosage ; Thiazoles/adverse effects ; Treatment Outcome ; Urinary Bladder, Overactive/diagnosis
Czasopismo naukowe
Tytuł :
Synthetic nanoparticle-conjugated bisindoles and hydrazinyl arylthiazole as novel antiamoebic agents against brain-eating amoebae.
Autorzy :
Kanwal; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, 21030, Malaysia; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Mungroo MR; Department of Biological Sciences, School of Science and Technology, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia.
Anwar A; Department of Biological Sciences, School of Science and Technology, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia. Electronic address: .
Ali F; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Khan S; Department of Biological Sciences, School of Science and Technology, Sunway University, Petaling Jaya, Selangor, 47500, Malaysia.
Abdullah MA; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, 21030, Malaysia.
Siddiqui R; Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, Sharjah, 26666, United Arab Emirates.
Khan KM; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia. Electronic address: .
Khan NA; Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, Sharjah, 26666, United Arab Emirates. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2020 Nov; Vol. 218, pp. 107979. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Amebiasis/*drug therapy
Balamuthia mandrillaris/*drug effects
Central Nervous System Protozoal Infections/*drug therapy
Indoles/*administration & dosage
Naegleria fowleri/*drug effects
Thiazoles/*administration & dosage
Amebiasis/parasitology ; Amebicides/administration & dosage ; Amebicides/chemistry ; Central Nervous System Protozoal Infections/parasitology ; HeLa Cells ; Humans ; Indoles/chemistry ; Inhibitory Concentration 50 ; Metal Nanoparticles ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation.
Autorzy :
Okumura K; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Akao M; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Yoshida T; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Kawata M; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Okazaki O; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Akashi S; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Eshima K; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Tanizawa K; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Fukuzawa M; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Hayashi T; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Akishita M; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Lip GYH; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
Yamashita T; From the Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto (K.O.), the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M. Akao), Onga Nakama Medical Association Onga Hospital, Onga (T. Yoshida), the Department of Cardiology, Akashi Medical Center, Akashi (M.K.), the Department of Cardiology, National Center for Global Health and Medicine (O.O.), Clinical Development Department III, Development Function, Research and Development Division (K.T., M.F.), and the Data Intelligence Group, Data Intelligence Department, Digital Transformation Management Division (T.H.), Daiichi Sankyo, the Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo (M. Akishita), and the Cardiovascular Institute (T. Yamashita), Tokyo, the Division of Cardiology, Hamada Medical Center, Hamada (S.A.), and the Department of Cardiology, Saga-Ken Medical Center Koseikan, Saga (K.E.) - all in Japan; the Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom (G.Y.H.L.); and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark (G.Y.H.L.).
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Corporate Authors :
ELDERCARE-AF Committees and Investigators
Źródło :
The New England journal of medicine [N Engl J Med] 2020 Oct 29; Vol. 383 (18), pp. 1735-1745. Date of Electronic Publication: 2020 Aug 30.
Typ publikacji :
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Atrial Fibrillation/*drug therapy
Embolism/*prevention & control
Factor Xa Inhibitors/*administration & dosage
Pyridines/*administration & dosage
Stroke/*prevention & control
Thiazoles/*administration & dosage
Aged, 80 and over ; Atrial Fibrillation/complications ; Atrial Fibrillation/mortality ; Double-Blind Method ; Embolism/etiology ; Factor Xa Inhibitors/adverse effects ; Female ; Follow-Up Studies ; Hemorrhage/chemically induced ; Humans ; Incidence ; Male ; Patient Dropouts/statistics & numerical data ; Pyridines/adverse effects ; Stroke/etiology ; Thiazoles/adverse effects
Czasopismo naukowe
Tytuł :
[New European approvals: Alpelisib for HRpos/HER2neg metastatic breast cancer with PIK3CA mutation].
Autorzy :
Corbaux P; Institut de cancérologie des hospices civils de Lyon, université Claude-Bernard Lyon 1, centre hospitalier Lyon sud, faculté de médecine Lyon-Sud, département d'oncologie médicale, 165, chemin du Grand-Revoyet, 69310 Pierre-Bénite, France. Electronic address: .
Sabatier R; Institut Paoli-Calmettes, Centre de recherche en cancérologie de Marseille, laboratoire d'oncologie prédictive, département d'oncologie médicale, Inserm UMR1068, CNRS UMR7258, Aix-Marseille Université, 13009 Marseille, France.
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Transliterated Title :
Nouvelles AMMs au niveau européen : alpélisib – cancer du sein RH+/HER2− métastatique avec mutation PIK3CA.
Źródło :
Bulletin du cancer [Bull Cancer] 2020 Oct; Vol. 107 (10), pp. 959-960. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Letter
MeSH Terms :
Estrogens*
Progesterone*
Breast Neoplasms/*drug therapy
Carcinoma, Ductal, Breast/*secondary
Class I Phosphatidylinositol 3-Kinases/*analysis
Neoplasm Proteins/*analysis
Neoplasms, Hormone-Dependent/*drug therapy
Receptor, ErbB-2/*analysis
Receptors, Estrogen/*analysis
Receptors, Progesterone/*analysis
Thiazoles/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/chemistry ; Breast Neoplasms, Male/chemistry ; Breast Neoplasms, Male/drug therapy ; Carcinoma, Ductal, Breast/chemistry ; Carcinoma, Ductal, Breast/drug therapy ; Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Clinical Trials as Topic ; Drug Approval ; Drug Resistance, Neoplasm ; Female ; Fulvestrant/administration & dosage ; Humans ; Male ; Multicenter Studies as Topic ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasms, Hormone-Dependent/chemistry ; Thiazoles/administration & dosage
Opinia redakcyjna
Tytuł :
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Autorzy :
Xiong R; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Zhang L; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Li S; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Sun Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Ding M; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Wang Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Zhao Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Wu Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Shang W; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Jiang X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Shan J; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Shen Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Tong Y; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Xu L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Chen Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Liu Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Zou G; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Lavillete D; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhao Z; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Wang R; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Zhu L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Xiao G; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China.
Lan K; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Li H; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. .
Xu K; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China. .; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. .
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Źródło :
Protein & cell [Protein Cell] 2020 Oct; Vol. 11 (10), pp. 723-739. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pandemics*
Antiviral Agents/*pharmacology
Coronavirus Infections/*drug therapy
Oxidoreductases/*antagonists & inhibitors
Pneumonia, Viral/*drug therapy
RNA Viruses/*drug effects
Thiazoles/*pharmacology
Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/physiology ; Binding Sites/drug effects ; Cell Line ; Coronavirus Infections/virology ; Crotonates/pharmacology ; Cytokine Release Syndrome/drug therapy ; Drug Evaluation, Preclinical ; Gene Knockout Techniques ; Humans ; Influenza A virus/drug effects ; Leflunomide/pharmacology ; Mice ; Mice, Inbred BALB C ; Orthomyxoviridae Infections/drug therapy ; Oseltamivir/therapeutic use ; Oxidoreductases/metabolism ; Pneumonia, Viral/virology ; Protein Binding/drug effects ; Pyrimidines/biosynthesis ; RNA Viruses/physiology ; Structure-Activity Relationship ; Thiazoles/therapeutic use ; Toluidines/pharmacology ; Ubiquinone/metabolism ; Virus Replication/drug effects
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Occurrence of methylisothiazolinone in water and soil samples in Poland and its biodegradation by Phanerochaete chrysosporium.
Autorzy :
Nowak M; Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237, Lodz, Poland.
Zawadzka K; Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237, Lodz, Poland.
Lisowska K; Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237, Lodz, Poland. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2020 Sep; Vol. 254, pp. 126723. Date of Electronic Publication: 2020 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Biodegradation, Environmental*
Phanerochaete/*metabolism
Thiazoles/*metabolism
Animals ; Biotransformation ; Daphnia/drug effects ; Environmental Pollution ; Poland ; Thiazoles/analysis ; Water Pollution, Chemical
Czasopismo naukowe
Tytuł :
A class of carbonic anhydrase IX/XII - selective carboxylate inhibitors.
Autorzy :
Alhameed RA; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Berrino E; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
Almarhoon Z; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
El-Faham A; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.; Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Supuran CT; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 549-554.
Typ publikacji :
Journal Article
MeSH Terms :
Acetates/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*classification
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Thiazoles/*pharmacology
Acetates/chemical synthesis ; Acetates/chemistry ; Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Direct oral anticoagulant plasma levels' striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience.
Autorzy :
Testa S; Haemostasis and Thrombosis Center, Cremona Hospital, Cremona, Italy.
Prandoni P; Arianna Anticoagulazione Foundation, Bologna, Italy.
Paoletti O; Haemostasis and Thrombosis Center, Cremona Hospital, Cremona, Italy.
Morandini R; Haemostasis and Thrombosis Center, Cremona Hospital, Cremona, Italy.
Tala M; Haemostasis and Thrombosis Center, Cremona Hospital, Cremona, Italy.
Dellanoce C; Haemostasis and Thrombosis Center, Cremona Hospital, Cremona, Italy.
Giorgi-Pierfranceschi M; Division of Internal Medicine, Cremona Hospital, Cremona, Italy.
Betti M; Division of Pneumology, Cremona Hospital, Cremona, Italy.
Battista Danzi G; Division of Cardiology, Cremona Hospital, Cremona, Italy.
Pan A; Division of Infectious Disease, Cremona Hospital, Cremona, Italy.
Palareti G; Arianna Anticoagulazione Foundation, Bologna, Italy.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Jun; Vol. 18 (6), pp. 1320-1323. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antithrombins/*blood
Antiviral Agents/*adverse effects
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Dabigatran/*blood
Factor Xa Inhibitors/*blood
Pneumonia, Viral/*drug therapy
Pyrazoles/*blood
Pyridines/*blood
Pyridones/*blood
Thiazoles/*blood
Administration, Oral ; Aged ; Aged, 80 and over ; Antithrombins/administration & dosage ; Antithrombins/adverse effects ; Antiviral Agents/administration & dosage ; Betacoronavirus/pathogenicity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Dabigatran/administration & dosage ; Dabigatran/adverse effects ; Darunavir/adverse effects ; Drug Interactions ; Drug Monitoring ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Female ; Hemorrhage/chemically induced ; Humans ; Italy ; Lopinavir/adverse effects ; Male ; Pandemics ; Patient Safety ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyridines/administration & dosage ; Pyridines/adverse effects ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Risk Assessment ; Risk Factors ; Ritonavir/adverse effects ; Severity of Illness Index ; Thiazoles/administration & dosage ; Thiazoles/adverse effects
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells.
Autorzy :
Chang YC; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kondapuram SK; Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014, India.
Yang TH; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Syed SB; Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014, India.
Cheng SM; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.
Lin TY; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lin YC; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Coumar MS; Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014, India.
Chang JY; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Leung E; Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand.
Cheung CHA; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Aug 15; Vol. 401, pp. 115080. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphatases/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Apoptosis Regulatory Proteins/*pharmacology
Mitochondrial Proteins/*pharmacology
Survivin/*antagonists & inhibitors
Thiazoles/*pharmacology
ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Adenosine Triphosphatases/metabolism ; Antineoplastic Agents/chemistry ; Apoptosis Regulatory Proteins/chemistry ; Biomimetic Materials/chemistry ; Biomimetic Materials/pharmacology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Gene Expression Regulation, Neoplastic ; Humans ; MCF-7 Cells ; Mitochondrial Proteins/chemistry ; Protein Structure, Secondary ; Survivin/biosynthesis ; Survivin/genetics ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
FDG Uptake in Brown Adipose Tissue Activated by a β3-Adrenergic Receptor Agonist Prescribed for Overactive Bladder.
Autorzy :
Okuyama C; From the Division of PET Imaging, Shiga Medical Center Research Institute.
Kikuchi R; Departments of Thoracic Surgery.
Ikeuchi T; Diagnostic Radiology, Shiga General Hospital, Moriyama, Japan.
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Źródło :
Clinical nuclear medicine [Clin Nucl Med] 2020 Aug; Vol. 45 (8), pp. 628-631.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Positron-Emission Tomography*
Acetanilides/*adverse effects
Adipose Tissue, Brown/*diagnostic imaging
Adrenergic Agonists/*adverse effects
Fluorodeoxyglucose F18/*pharmacokinetics
Radiopharmaceuticals/*pharmacokinetics
Thiazoles/*adverse effects
Acetanilides/therapeutic use ; Adipose Tissue, Brown/drug effects ; Adipose Tissue, Brown/metabolism ; Adrenal Gland Neoplasms/diagnostic imaging ; Adrenergic Agonists/therapeutic use ; Aged, 80 and over ; Female ; Humans ; Pheochromocytoma/diagnostic imaging ; Thiazoles/therapeutic use ; Urinary Bladder, Overactive/drug therapy
Czasopismo naukowe
Tytuł :
Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors.
Autorzy :
Bossone KA; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey, United States.; Department of Pharmaceutical Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States.
Ellis JA; Department of Pharmaceutical Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States.
Holaska JM; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey, United States.; Department of Pharmaceutical Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States.
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Źródło :
Muscle & nerve [Muscle Nerve] 2020 Jul; Vol. 62 (1), pp. 128-136. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Differentiation/*drug effects
Histone Acetyltransferases/*antagonists & inhibitors
Muscular Dystrophy, Emery-Dreifuss/*drug therapy
Muscular Dystrophy, Emery-Dreifuss/*pathology
Stem Cells/*drug effects
Thiazoles/*therapeutic use
Animals ; Cell Differentiation/physiology ; Cells, Cultured ; Histone Acetyltransferases/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Stem Cells/pathology ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł :
A new thiodiketopiperzaine from the marine sponge Tedania sp.
Autorzy :
Zhang H; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, P. R. China.
Lai W; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, P. R. China.
Guan ZB; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, P. R. China.
Liao XJ; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, P. R. China.
Zhao BX; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, P. R. China.
Xu SH; Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou, P. R. China.
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Źródło :
Natural product research [Nat Prod Res] 2020 Apr; Vol. 34 (8), pp. 1113-1117. Date of Electronic Publication: 2019 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Cytotoxins/*isolation & purification
Diketopiperazines/*isolation & purification
Porifera/*chemistry
Thiazoles/*isolation & purification
Animals ; Cell Line ; Cytotoxins/chemistry ; Cytotoxins/pharmacology ; Diketopiperazines/chemistry ; Diketopiperazines/pharmacology ; Humans ; Molecular Conformation ; Molecular Structure ; Spectrum Analysis ; Thiazoles/chemistry ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł :
The putative endogenous AHR ligand ITE reduces JAG1 and associated NOTCH1 signaling in triple negative breast cancer cells.
Autorzy :
Piwarski SA; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. Electronic address: .
Thompson C; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. Electronic address: .
Chaudhry AR; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. Electronic address: .
Denvir J; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. Electronic address: .
Primerano DA; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. Electronic address: .
Fan J; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. Electronic address: .
Salisbury TB; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Apr; Vol. 174, pp. 113845. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Agents/*metabolism
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Indoles/*metabolism
Jagged-1 Protein/*metabolism
Receptor, Notch1/*metabolism
Receptors, Aryl Hydrocarbon/*metabolism
Thiazoles/*metabolism
Triple Negative Breast Neoplasms/*metabolism
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Female ; Humans ; Indoles/pharmacology ; Indoles/therapeutic use ; Jagged-1 Protein/antagonists & inhibitors ; Ligands ; MCF-7 Cells ; Receptor, Notch1/antagonists & inhibitors ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Thiazoles/pharmacology ; Thiazoles/therapeutic use ; Triple Negative Breast Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice.
Autorzy :
Ohno S; Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
Ikenaka Y; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan; Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa.
Onaru K; Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
Kubo S; Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
Sakata N; Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
Hirano T; Division of Drug and Structural Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Mantani Y; Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
Yokoyama T; Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan.
Takahashi K; Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.
Kato K; Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.
Arizono K; Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Japan.
Ichise T; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan.
Nakayama SMM; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan.
Ishizuka M; Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060-0818, Japan.
Hoshi N; Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657-8501, Japan. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Apr 01; Vol. 322, pp. 32-38. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Maternal-Fetal Exchange*
Fetal Blood/*metabolism
Guanidines/*blood
Insecticides/*blood
Neonicotinoids/*blood
Thiazoles/*blood
Animals ; Biotransformation ; Female ; Guanidines/administration & dosage ; Guanidines/pharmacokinetics ; Guanidines/toxicity ; Insecticides/administration & dosage ; Insecticides/pharmacokinetics ; Insecticides/toxicity ; Maternal Exposure ; Mice, Inbred ICR ; Neonicotinoids/administration & dosage ; Neonicotinoids/pharmacokinetics ; Neonicotinoids/toxicity ; Pregnancy ; Risk Assessment ; Thiazoles/administration & dosage ; Thiazoles/pharmacokinetics ; Thiazoles/toxicity ; Toxicokinetics
Czasopismo naukowe
Tytuł :
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
Autorzy :
Smithen DA; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Leung LMH; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Challinor M; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
Lawrence R; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
Tang H; Molecular Oncology Team, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
Niculescu-Duvaz D; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Pearce SP; Clinical and Experimental Pharmacology, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
Mcleary R; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Lopes F; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Aljarah M; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Brown M; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Johnson L; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
Thomson G; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
Marais R; Molecular Oncology Team, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
Springer C; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Macclesfield SK10 4TG, United Kingdom.; Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Mar 12; Vol. 63 (5), pp. 2308-2324. Date of Electronic Publication: 2019 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Oxidoreductases/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Neoplasms/*drug therapy
Protein-Lysine 6-Oxidase/*antagonists & inhibitors
Thiazoles/*pharmacology
Amination ; Amino Acid Oxidoreductases/metabolism ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/therapeutic use ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Neoplasms/enzymology ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein-Lysine 6-Oxidase/metabolism ; Rats ; Sulfinic Acids/chemistry ; Sulfinic Acids/pharmacokinetics ; Sulfinic Acids/pharmacology ; Sulfinic Acids/therapeutic use ; Thiazoles/chemistry ; Thiazoles/pharmacokinetics ; Thiazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Jurisdictional Guidance on DOAC Use-Will It Affect Practice? A Comparison of European, American, and Canadian Product Monographs.
Autorzy :
Lamb DA; Saskatchewan Health Authority, Saskatoon, SK, Canada.
Bungard TJ; University of Alberta, Edmonton, AB, Canada.
Lowerison J; Alberta Health Services, Calgary, AB, Canada.
Semchuk WM; Saskatchewan Health Authority, Regina, SK, Canada.
Thomson P; University of Manitoba and Winnipeg Regional Health Authority, Winnipeg, MB, Canada.
Brocklebank C; Alberta Health Services, Calgary, AB, Canada.
Bolt J; Interior Health Authority and University of British Columbia Faculty of Pharmaceutical Sciences, Kelowna, BC, Canada.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2020 Mar; Vol. 54 (3), pp. 277-282. Date of Electronic Publication: 2019 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Practice Guidelines as Topic*
Anticoagulants/*adverse effects
Dabigatran/*adverse effects
Drug Approval/*legislation & jurisprudence
Pyrazoles/*adverse effects
Pyridines/*adverse effects
Pyridones/*adverse effects
Rivaroxaban/*adverse effects
Thiazoles/*adverse effects
Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Canada ; Dabigatran/administration & dosage ; Dabigatran/therapeutic use ; Drug Industry/legislation & jurisprudence ; Drug Interactions ; Europe ; Humans ; Pyrazoles/administration & dosage ; Pyrazoles/therapeutic use ; Pyridines/administration & dosage ; Pyridines/therapeutic use ; Pyridones/administration & dosage ; Pyridones/therapeutic use ; Rivaroxaban/administration & dosage ; Rivaroxaban/therapeutic use ; Thiazoles/administration & dosage ; Thiazoles/therapeutic use ; United States ; Venous Thromboembolism/drug therapy
Czasopismo naukowe
Tytuł :
Association between plasma concentration of edoxaban determined by direct and indirect methods in Japanese patients with non-valvular atrial fibrillation (CVI ARO 7).
Autorzy :
Suzuki S; Department of Cardiovascular Medicine, The Cardiovascular Institute, 3-2-19 Nishiazabu, Minato-Ku, Tokyo, 106-0031, Japan. .
Morishima Y; Medical Science Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Takita A; Safety and Risk Management Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Otsuka T; Department of Cardiovascular Medicine, The Cardiovascular Institute, 3-2-19 Nishiazabu, Minato-Ku, Tokyo, 106-0031, Japan.
Yagi N; Department of Cardiovascular Medicine, The Cardiovascular Institute, 3-2-19 Nishiazabu, Minato-Ku, Tokyo, 106-0031, Japan.
Arita T; Department of Cardiovascular Medicine, The Cardiovascular Institute, 3-2-19 Nishiazabu, Minato-Ku, Tokyo, 106-0031, Japan.
Yamashita T; Department of Cardiovascular Medicine, The Cardiovascular Institute, 3-2-19 Nishiazabu, Minato-Ku, Tokyo, 106-0031, Japan.
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Źródło :
Heart and vessels [Heart Vessels] 2020 Mar; Vol. 35 (3), pp. 409-416. Date of Electronic Publication: 2019 Sep 14.
Typ publikacji :
Comparative Study; Journal Article; Observational Study
MeSH Terms :
Blood Coagulation Tests*
Chromatography, Liquid*
Drug Monitoring*
Tandem Mass Spectrometry*
Atrial Fibrillation/*drug therapy
Blood Coagulation/*drug effects
Factor Xa Inhibitors/*blood
Pyridines/*blood
Thiazoles/*blood
Aged ; Atrial Fibrillation/blood ; Atrial Fibrillation/diagnosis ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Female ; Humans ; Japan ; Male ; Middle Aged ; Predictive Value of Tests ; Pyridines/administration & dosage ; Pyridines/adverse effects ; Registries ; Reproducibility of Results ; Thiazoles/administration & dosage ; Thiazoles/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Fatostatin inhibits the development of endometrial carcinoma in endometrial carcinoma cells and a xenograft model by targeting lipid metabolism.
Autorzy :
Yao L; Department of Gynecology, Fourth Hospital of Hebei Medical University, China.
Chen S; Department of Gynecology, Fourth Hospital of Hebei Medical University, China. Electronic address: .
Li W; Department of Gynecology, Fourth Hospital of Hebei Medical University, China.
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 May 15; Vol. 684, pp. 108327. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Endometrial Neoplasms/*drug therapy
Lipid Metabolism/*drug effects
Pyridines/*therapeutic use
Thiazoles/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 8/metabolism ; Caspase 9/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Cholesterol/metabolism ; Fatty Acids, Nonesterified/metabolism ; Female ; Humans ; Mice, Inbred BALB C ; Pyridines/pharmacology ; Thiazoles/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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