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Wyszukujesz frazę ""Thiophenes"" wg kryterium: Temat


Tytuł :
Design, synthesis, anti-inflammatory evaluation and molecular docking of novel thiophen-2-ylmethylene-based derivatives as potential TNF-α production inhibitors.
Autorzy :
Dawood DH; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Bohouth St, Dokki, Giza 12622, Egypt. Electronic address: .
Nossier ES; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.
Abdelhameed MF; Pharmacology Department, National Research Centre, 33 El Bohouth St, Dokki, Giza 12622, Egypt.
Asaad GF; Pharmacology Department, National Research Centre, 33 El Bohouth St, Dokki, Giza 12622, Egypt.
Abd El-Rahman SS; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2022 May; Vol. 122, pp. 105726. Date of Electronic Publication: 2022 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Thiophenes*/pharmacology
Thiophenes*/therapeutic use
Tumor Necrosis Factor-alpha*
Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/pharmacology ; Drug Design ; Edema/chemically induced ; Edema/drug therapy ; Edema/pathology ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo.
Autorzy :
Chen X; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Yan Y; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Du J; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Shen X; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
He C; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Pan H; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Zhu J; Second Clinical Medical College Anhui Medical University, Hefei, 230032, PR China.
Liu X; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jun 05; Vol. 236, pp. 114368. Date of Electronic Publication: 2022 Apr 10.
Typ publikacji :
Journal Article
MeSH Terms :
Cathepsin C*
Thiophenes*/pharmacology
Animals ; Anti-Inflammatory Agents ; Pyridines/pharmacology ; Serine Endopeptidases/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Theoretical Studies of Furan and Thiophene Nanothreads: Structures, Cycloaddition Barriers, and Activation Volumes.
Autorzy :
Chen B; Donostia International Physics Center, Paseo Manuel de Lardizabal, 4, Donostia-San Sebastian 20018, Spain.; Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, Bilbao 48009, Spain.
Crespi VH; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.; Department of Physics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.; Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.; Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Hoffmann R; Baker Laboratory, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2022 May 25; Vol. 144 (20), pp. 9044-9056. Date of Electronic Publication: 2022 May 12.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Furans*/chemistry
Thiophenes*
Cycloaddition Reaction ; Models, Theoretical ; Polymers/chemistry
Czasopismo naukowe
Tytuł :
Highly Selective Detection of Al by Carboxamide-Based Fluorescent Chemosensor.
Autorzy :
Heo JS; Department of Fine Chem, SNUT (Seoul National Univ. of Sci. and Tech.), Seoul, 01078, Korea.
Gil D; Department of Fine Chem, SNUT (Seoul National Univ. of Sci. and Tech.), Seoul, 01078, Korea.
Kim C; Department of Fine Chem, SNUT (Seoul National Univ. of Sci. and Tech.), Seoul, 01078, Korea. .
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Źródło :
Journal of fluorescence [J Fluoresc] 2022 May; Vol. 32 (3), pp. 825-833.
Typ publikacji :
Wiadomości
MeSH Terms :
Fluorescent Dyes*/chemistry
Thiophenes*
Aluminum/*analysis
Amides/*chemistry
Density Functional Theory
Periodyk
Tytuł :
Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents.
Autorzy :
Hwang J; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Qiu X; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Borgelt L; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Haacke N; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Kanis L; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Petroulia S; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Gasper R; Crystallography and Biophysics Unit, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
Schiller D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund 44227, Germany.
Lampe P; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Compound Management and Screening Center, Dortmund 44227, Germany.
Sievers S; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Compound Management and Screening Center, Dortmund 44227, Germany.
Imig J; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany.
Wu P; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund 44227, Germany. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Mar 15; Vol. 58, pp. 116653. Date of Electronic Publication: 2022 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Endoribonucleases/*chemistry
Thiophenes/*pharmacology
Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Apoptosis/drug effects ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Endoribonucleases/metabolism ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Thiophenes/chemistry ; Thiophenes/metabolism
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors.
Autorzy :
Ushiki Y; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. Electronic address: .
Kawabe K; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Yamamoto-Okada K; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Uneuchi F; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Asanuma Y; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Yamaguchi C; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Ohta H; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Shibata T; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Abe T; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Okumura-Kitajima L; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Kosai Y; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Endo M; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Otake K; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Munetomo E; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Takahashi T; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
Kakinuma H; Taisho Pharmaceutical Co Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Mar 01; Vol. 59, pp. 128572. Date of Electronic Publication: 2022 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Pyrazoles/*pharmacology
Sodium-Phosphate Cotransporter Proteins, Type IIb/*antagonists & inhibitors
Thiophenes/*pharmacology
Administration, Oral ; Animals ; Dose-Response Relationship, Drug ; Humans ; Injections, Intravenous ; Male ; Molecular Structure ; Pyrazoles/administration & dosage ; Pyrazoles/chemistry ; Rats ; Rats, Sprague-Dawley ; Sodium-Phosphate Cotransporter Proteins, Type IIb/metabolism ; Solubility ; Structure-Activity Relationship ; Thiophenes/administration & dosage ; Thiophenes/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase.
Autorzy :
Lee HF; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.
Lacbay CM; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.
Boutin R; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.
Matralis AN; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.
Park J; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.
Waller DD; Department of Medicine, McGill University, Montreal, Quebec H3A 1A1, Canada.; Division of Hematology, McGill University Health Center, Montreal, Quebec H4A 3J1, Canada.
Guan TL; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.
Sebag M; Department of Medicine, McGill University, Montreal, Quebec H3A 1A1, Canada.; Division of Hematology, McGill University Health Center, Montreal, Quebec H4A 3J1, Canada.
Tsantrizos YS; Department of Chemistry, McGill University, Montreal, Quebec H3A 0B8, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2022 Feb 10; Vol. 65 (3), pp. 2471-2496. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Enzyme Inhibitors/*therapeutic use
Geranylgeranyl-Diphosphate Geranylgeranyltransferase/*antagonists & inhibitors
Multiple Myeloma/*drug therapy
Pyrimidines/*therapeutic use
Thiophenes/*therapeutic use
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/toxicity ; Bone Marrow Cells/drug effects ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/toxicity ; Female ; Fungal Proteins/antagonists & inhibitors ; Fungal Proteins/metabolism ; Geranylgeranyl-Diphosphate Geranylgeranyltransferase/metabolism ; Humans ; Liver/drug effects ; Male ; Mice, Inbred C57BL ; Molecular Structure ; Protein Binding ; Pyrimidines/chemical synthesis ; Pyrimidines/metabolism ; Pyrimidines/toxicity ; Rats ; Saccharomyces cerevisiae/enzymology ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/metabolism ; Thiophenes/toxicity
Czasopismo naukowe
Tytuł :
Carbazole-thiophene based fluorescent probe for selective detection of Cu and its live cell imaging.
Autorzy :
Wang H; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412008, PR China.
Wang P; College of Packaging and Materials Engineering, Hunan University of Technology, Zhuzhou 412007, PR China.
Niu L; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, PR China.
Liu C; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, PR China.
Xiao Y; College of Packaging and Materials Engineering, Hunan University of Technology, Zhuzhou 412007, PR China. Electronic address: .
Tang Y; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412008, PR China. Electronic address: .
Chen Y; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412008, PR China. Electronic address: .
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2022 Oct 05; Vol. 278, pp. 121257. Date of Electronic Publication: 2022 Apr 22.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorescent Dyes*
Thiophenes*
Carbazoles ; Copper/metabolism ; Spectrometry, Fluorescence/methods
Czasopismo naukowe
Tytuł :
Symmetrical end-capped molecular engineering of star-shaped triphenylamine-based derivatives having remarkable photovoltaic properties for efficient organic solar cells.
Autorzy :
Shahzadi A; Department of Chemistry, University of Agriculture, Faisalabad, 38000, Pakistan.
Iqbal J; Department of Chemistry, University of Agriculture, Faisalabad, 38000, Pakistan. .; Punjab Bio-Energy Institute, University of Agriculture, Faisalabad, 38000, Pakistan. .
Akram SJ; Department of Chemistry, University of Agriculture, Faisalabad, 38000, Pakistan.
Rasool A; Department of Chemistry, University of Agriculture, Faisalabad, 38000, Pakistan.
El-Badry YA; Department of Chemistry, Faculty of Science, Taif University, Khurma, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Khera RA; Department of Chemistry, University of Agriculture, Faisalabad, 38000, Pakistan. .
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Źródło :
Journal of molecular modeling [J Mol Model] 2022 Apr 30; Vol. 28 (5), pp. 132. Date of Electronic Publication: 2022 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Electronics*
Thiophenes*
Density Functional Theory
Czasopismo naukowe
Tytuł :
Supramolecular Polymerization of a Photo-Fluttering Chiral Monomer: A Temporarily Suspendable Chain Growth by Light.
Autorzy :
Aoki T; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
Ueda M; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.
Aida T; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.; RIKEN Center for Emergent Matter Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Itoh Y; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan.; Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2022 Apr 27; Vol. 144 (16), pp. 7080-7084. Date of Electronic Publication: 2022 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Thiophenes*/chemistry
Polymerization
Czasopismo naukowe
Tytuł :
Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent fungistatic and fungicidal reagents based on a conformational restriction strategy.
Autorzy :
Yin W; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Liu L; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Jiang H; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Wu T; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Cui H; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zhang Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Gao Z; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Sun Y; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Qin Q; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zhao L; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Su X; The School of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zhao D; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: .
Cheng M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2022 Apr 05; Vol. 233, pp. 114195. Date of Electronic Publication: 2022 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents*/pharmacology
Thiophenes*/pharmacology
Animals ; Azoles/pharmacology ; Humans ; Indicators and Reagents ; Mammals ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Influence of Large Steric Hinderance Substituent Position on Conformation and Charge Transfer Process for Non-Fused Ring Acceptors.
Autorzy :
Li J; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Li H; School of Chemistry and Biology Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Ma L; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Xu Y; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Cui Y; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Wang J; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Ren J; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Zhu J; School of Chemistry and Biology Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Zhang S; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.; School of Chemistry and Biology Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.
Hou J; State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory for Molecular, Sciences CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
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Źródło :
Small methods [Small Methods] 2022 Apr; Vol. 6 (4), pp. e2200007. Date of Electronic Publication: 2022 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Electrons*
Thiophenes*/chemistry
Molecular Conformation ; Molecular Structure ; Polymers/chemistry
Czasopismo naukowe
Tytuł :
Gold(I)-Catalyzed Intramolecular Hydrothiophenylation of N -Thiophen-3-yl Alkynylamides for Accessing Thieno[3,2- b ]pyridine-5(4 H )-ones: Development of F-Actin Specific Fluorescent Probes.
Autorzy :
Sung DB; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Republic of Korea.
Han JH; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.; Graduate School of Medical Science, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Kim YK; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.; Graduate School of Medical Science, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Mun BH; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Republic of Korea.
Park S; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Republic of Korea.; Department of Marine Biotechnology, Korea University of Science and Technology, Deajeon 34113, Republic of Korea.
Kim HS; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.; Graduate School of Medical Science, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Lee JS; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Republic of Korea.; Department of Marine Biotechnology, Korea University of Science and Technology, Deajeon 34113, Republic of Korea.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2022 Apr 01; Vol. 87 (7), pp. 4936-4950. Date of Electronic Publication: 2022 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescent Dyes*/chemistry
Thiophenes*
Actins ; Catalysis ; Gold ; Pyridines/chemistry
Czasopismo naukowe
Tytuł :
Synthesis of Substituted Thiophenes through Dehydration and Heterocyclization of Alkynols.
Autorzy :
Li J; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Liu Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Chen Z; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Li J; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Ji X; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Chen L; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Huang Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
Liu Q; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.; Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing 100084, China.
Li Y; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529090, China.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2022 Mar 04; Vol. 87 (5), pp. 3555-3566. Date of Electronic Publication: 2022 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dehydration*
Thiophenes*
Alkynes ; Cyclization ; Humans ; Sulfur
Czasopismo naukowe
Tytuł :
Thiophene Ring-opening Reactions III: One-Pot Synthesis and Antitumor Activity of 1,3,4-Thiadiazoline-Benzothiazolo[3,2- b ]pyridazine Hybrids†.
Autorzy :
Abdullah AH; Department of Chemistry, Faculty of Science, The University of Jordan, Amman, 11942, Jordan.; Faculty of Pharmacy, Zarqa University, Zarqa, 13132, Jordan.
Zahra JA; Department of Chemistry, Faculty of Science, The University of Jordan, Amman, 11942, Jordan.
Sabri SS; Department of Chemistry, Faculty of Science, The University of Jordan, Amman, 11942, Jordan.
Awwadi FF; Department of Chemistry, Faculty of Science, The University of Jordan, Amman, 11942, Jordan.
Abadleh MM; Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, 11196, Jordan.
Abdallah QM; Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, 11196, Jordan.
El-Abadelah MM; Department of Chemistry, Faculty of Science, The University of Jordan, Amman, 11942, Jordan.
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Źródło :
Current organic synthesis [Curr Org Synth] 2022 Mar 03; Vol. 19 (2), pp. 279-290.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pyridazines*/chemistry
Pyridazines*/pharmacology
Thiophenes*
Crystallography, X-Ray
Czasopismo naukowe
Tytuł :
Preclinical discovery and development of oliceridine (Olinvyk®) for the treatment of post-operative pain.
Autorzy :
Azzam AAH; University Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, Hodgkin Building, University of Leicester, Leicester, UK.
Lambert DG; University Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, Hodgkin Building, University of Leicester, Leicester, UK.
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Źródło :
Expert opinion on drug discovery [Expert Opin Drug Discov] 2022 Mar; Vol. 17 (3), pp. 215-223. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pain, Postoperative*/drug therapy
Spiro Compounds*/adverse effects
Thiophenes*/adverse effects
Analgesics, Opioid/adverse effects ; Humans ; Morphine/adverse effects
Czasopismo naukowe
Tytuł :
Efficacy and safety evaluation of avatrombopag in immune thrombocytopenia: analyses of a phase III study and long-term extension.
Autorzy :
Al-Samkari H; Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nagalla S; Division of Benign Hematology, Miami Cancer Institute, Miami, FL, USA.
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Źródło :
Platelets [Platelets] 2022 Feb 17; Vol. 33 (2), pp. 257-264. Date of Electronic Publication: 2021 Feb 14.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Purpura, Thrombocytopenic, Idiopathic/*drug therapy
Receptors, Thrombopoietin/*therapeutic use
Thiazoles/*therapeutic use
Thiophenes/*therapeutic use
Double-Blind Method ; Female ; Humans ; Male ; Thiazoles/pharmacology ; Thiophenes/pharmacology
Czasopismo naukowe
Tytuł :
Determination of the semiexperimental equilibrium structure of 2-acetylthiophene in the presence of methyl internal rotation and substituent effects compared to thiophene.
Autorzy :
Dindić C; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, Aachen 52074, Germany.
Ludovicy J; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, Aachen 52074, Germany.
Terzi V; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, Aachen 52074, Germany.
Lüchow A; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, Aachen 52074, Germany.
Vogt N; Section of Chemical Information Systems, University of Ulm, Albert-Einstein-Allee 47, Ulm 89081, Germany.; Department of Inorganic Chemistry, Lomonosov Moscow State University, Moscow 119991, Russian Federation.
Demaison J; Section of Chemical Information Systems, University of Ulm, Albert-Einstein-Allee 47, Ulm 89081, Germany.
Nguyen HVL; Univ Paris Est Creteil and Université de Paris, CNRS, LISA, Créteil 94010, France.; Institut Universitaire de France (IUF), Paris cedex 05 75231, France. .
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Źródło :
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2022 Feb 09; Vol. 24 (6), pp. 3804-3815. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Microwaves*
Thiophenes*
Fourier Analysis ; Molecular Conformation
Czasopismo naukowe
Tytuł :
New Experimental Conditions for Diels-Alder and Friedel-Crafts Alquilation Reactions with Thiophene: A New Selenocyanate with Potent Activity against Cancer.
Autorzy :
Calvo-Martín G; Departamento de Tecnología y Química Farmacéuticas, Facultad de Farmacia y Nutrición, Universidad de Navarra, Irunlarrea 1, E-31008 Pamplona, Spain.
Plano D; Departamento de Tecnología y Química Farmacéuticas, Facultad de Farmacia y Nutrición, Universidad de Navarra, Irunlarrea 1, E-31008 Pamplona, Spain.; Unidad de Onco-Hematología, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, E-31008 Pamplona, Spain.
Sanmartín C; Departamento de Tecnología y Química Farmacéuticas, Facultad de Farmacia y Nutrición, Universidad de Navarra, Irunlarrea 1, E-31008 Pamplona, Spain.; Unidad de Onco-Hematología, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, E-31008 Pamplona, Spain.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 Feb 01; Vol. 27 (3). Date of Electronic Publication: 2022 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cyanates/*pharmacology
Selenium Compounds/*pharmacology
Thiophenes/*chemistry
Cell Cycle/drug effects ; Cell Line, Tumor ; Cyanates/chemistry ; Cycloaddition Reaction ; Drug Screening Assays, Antitumor ; Humans ; Lewis Acids/chemistry ; Selenium Compounds/chemistry ; Thiophenes/pharmacology
Czasopismo naukowe
Tytuł :
Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents.
Autorzy :
Zhao L; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Sun Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Yin W; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Tian L; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Sun N; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zheng Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zhang C; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zhao S; Key Laboratory of Receptor-Mediated Gene Regulation and Drug Discovery, School of Medicine, Henan University, Kaifeng, 475004, China.
Su X; The School of Life Science and Biopharmaceutical, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zhao D; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: .
Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jan 15; Vol. 228, pp. 113987. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antifungal Agents/*pharmacology
Oxazoles/*pharmacology
Thiophenes/*pharmacology
Animals ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Aspergillus fumigatus/drug effects ; Candida albicans/drug effects ; Cryptococcus neoformans/drug effects ; Dose-Response Relationship, Drug ; Humans ; Microbial Sensitivity Tests ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure ; Oxazoles/chemical synthesis ; Oxazoles/chemistry ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/chemistry
Czasopismo naukowe

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