Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Ukraiński (UK)
Przejdź do strony domowej biblioteki Uniwersytet Ekonomiczny we Wrocławiu Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaUniwersytet Ekonomiczny we Wrocławiu

Wyszukujesz frazę ""Thioredoxin"" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-20 z 19398
Tytuł:
Methionine restriction exposes a targetable redox vulnerability of triple-negative breast cancer cells by inducing thioredoxin reductase.
Autorzy:
Malin D; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Lee Y; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Chepikova O; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Department of Biotechnology, Sirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia.
Strekalova E; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Carlson A; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Cryns VL; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA. .
Pokaż więcej
Źródło:
Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Dec; Vol. 190 (3), pp. 373-387. Date of Electronic Publication: 2021 Sep 22.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin-Disulfide Reductase*/genetics
Thioredoxin-Disulfide Reductase*/metabolism
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Animals ; Auranofin/pharmacology ; Humans ; Methionine/metabolism ; Mice ; Oxidation-Reduction ; Thioredoxin Reductase 1/genetics ; Thioredoxin Reductase 1/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis and discovery of Baylis-Hillman adducts as potent and selective thioredoxin reductase inhibitors for cancer treatment.
Autorzy:
He YL; Natural Medicine Research & Development Center, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Zhong M; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Song ZL; Natural Medicine Research & Development Center, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Shen YK; Lizhi College, Xi'an Jiaotong University, No. 28, Xianning West Road, Xi'an, Shaanxi 710049, China.
Zhao L; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of the Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address: .
Fang J; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Pokaż więcej
Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Feb 01; Vol. 79, pp. 117169. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin-Disulfide Reductase*/metabolism
Neoplasms*/drug therapy
Humans ; Oxidative Stress ; Oxidation-Reduction
Czasopismo naukowe
Szczegóły
Tytuł:
Menadione inhibits thioredoxin reductase 1 via arylation at the Sec substitution.
Autorzy:
Sun S; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Xu W; School of Ocean Science and Technology (OST) & Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), Dalian University of Technology, Panjin 124221, China.
Zhang Y; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Yang Y; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Ma Q; Chinese Academy of Inspection and Quarantine, Beijing 100176, China. Electronic address: .
Xu J; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China. Electronic address: .
Pokaż więcej
Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2021 Aug 20; Vol. 172, pp. 482-489. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Thioredoxin Reductase 1*/genetics
Thioredoxin Reductase 1*/metabolism
Vitamin K 3*/pharmacology
NADP ; Oxidation-Reduction ; Superoxides ; Thioredoxin-Disulfide Reductase/genetics ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
A novel thioredoxin glutathione reductase from evolutionary ancient metazoan Hydra.
Autorzy:
Perween N; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India; Department of Zoology, M. C. E. Society's Abeda Inamdar Senior College, Pune, 411001, India.
Pekhale K; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India.
Haval G; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India; Department of Zoology, Abasaheb Garware College, Pune, 411004, India.
Mittal S; Department of Biotechnology, Savitribai Phule Pune University, Pune, 411007, India.
Ghaskadbi S; Developmental Biology Group, MACS-Agharkar Research Institute, Pune, 411004, India.
Ghaskadbi SS; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India. Electronic address: .
Pokaż więcej
Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 31; Vol. 637, pp. 23-31. Date of Electronic Publication: 2022 Nov 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Thioredoxin-Disulfide Reductase*/genetics
Thioredoxin-Disulfide Reductase*/metabolism
Hydra*/genetics
Hydra*/metabolism
Animals ; Humans ; Glutathione Reductase/genetics ; Glutathione Reductase/metabolism ; Selenocysteine/chemistry ; Selenocysteine/metabolism ; Glutathione Disulfide/metabolism ; Hydrogen Peroxide ; Phylogeny ; Dinitrochlorobenzene ; HEK293 Cells ; Glutathione/metabolism ; Thioredoxins/genetics ; Thioredoxins/metabolism ; Oxidation-Reduction ; Antioxidants/metabolism ; Mammals/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells.
Autorzy:
Yang R; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Sun S; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Guo Y; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Meng Y; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Liu H; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Shi M; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Guan S; State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, China.; Research & Educational Center for the Control Engineering of Translational Precision Medicine, School of Biomedical Engineering, Dalian University of Technology, Dalian 116024, China.
Xu J; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 23; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Dimethyl Fumarate*/pharmacology
Dimethyl Fumarate*/chemistry
Thioredoxin Reductase 1*/metabolism
Mice ; Animals ; RAW 264.7 Cells ; Inflammation/drug therapy ; Cytokines ; Anti-Inflammatory Agents/pharmacology ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma.
Autorzy:
Kalın ŞN; Atatürk University, Science Faculty, Department of Molecular Biology and Genetics, 25240 Erzurum, Türkiye; Atatürk University, East Anatolia High Technology Application and Research Center, 25240 Erzurum, Turkey.
Altay A; Erzincan Binali Yıldırım University, Faculty of Science and Arts, Department of Chemistry, 24002 Erzincan, Turkey.
Budak H; Atatürk University, Science Faculty, Department of Molecular Biology and Genetics, 25240 Erzurum, Türkiye. Electronic address: .
Pokaż więcej
Źródło:
Life sciences [Life Sci] 2022 Dec 01; Vol. 310, pp. 121093. Date of Electronic Publication: 2022 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin Reductase 1*
Breast Neoplasms*/pathology
Humans ; Female ; Carboplatin/pharmacology ; Carboplatin/therapeutic use ; MCF-7 Cells ; Apoptosis ; Cell Proliferation ; Cell Line, Tumor
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors.
Autorzy:
Zhou J; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Yu LZ; School of Pharmacy, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Fan YL; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Guo CH; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Lv XM; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Zhou ZY; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Huang HD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Miao DD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Zhang SP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Li XY; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
Zhao PP; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
Liu XP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
Hu WH; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
Zhang C; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
Pokaż więcej
Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114860. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase*/antagonists & inhibitors
Reactive Oxygen Species*
Thioredoxin Reductase 1*/antagonists & inhibitors
Colorectal Neoplasms*/enzymology
Cell Line, Tumor ; Humans ; Apoptosis/drug effects
Czasopismo naukowe
Szczegóły
Tytuł:
Targeted inhibition of TXNRD1 prevents cartilage extracellular matrix degeneration by activating Nrf2 pathway in osteoarthritis.
Autorzy:
Liang J; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Wang S; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Hu J; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Hong X; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Zhu M; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Liu X; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Alswadeh M; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Mo F; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China. Electronic address: .
Dai M; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China. Electronic address: .
Pokaż więcej
Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 20; Vol. 635, pp. 267-276. Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cartilage, Articular*/metabolism
Osteoarthritis*/metabolism
Thioredoxin Reductase 1*/genetics
Animals ; Mice ; Auranofin/pharmacology ; Chondrocytes/metabolism ; Extracellular Matrix/metabolism ; Interleukin-1beta/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Revealing PACMA 31 as a new chemical type TrxR inhibitor to promote cancer cell apoptosis.
Autorzy:
Xu Q; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Zhang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.. Electronic address: .
Zhao Z; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Chu Y; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Fang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.. Electronic address: .
Pokaż więcej
Źródło:
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Oct; Vol. 1869 (10), pp. 119323. Date of Electronic Publication: 2022 Jul 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms*/drug therapy
Thioredoxin-Disulfide Reductase*/metabolism
Thioredoxin-Disulfide Reductase*/pharmacology
Intracellular Signaling Peptides and Proteins/*metabolism
Apoptosis ; Enzyme Inhibitors/pharmacology ; Humans ; Molecular Docking Simulation ; Thioredoxins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Proteomic profiling of Deinococcus radiodurans with response to thioredoxin reductase inhibitor and ionizing radiation treatment.
Autorzy:
M S; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India.
N RP; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India.
Chakraborty A; UGC-DAE Consortium for Scientific Research, Kolkata Centre, 700098, West Bengal, India.
Rajendrasozhan S; Department of Chemistry, College of Science, University of Hail, Hail, Saudi Arabia.
Pokaż więcej
Źródło:
Journal of proteomics [J Proteomics] 2022 Sep 15; Vol. 267, pp. 104697. Date of Electronic Publication: 2022 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deinococcus*/genetics
Deinococcus*/metabolism
Deinococcus*/radiation effects
Thioredoxin-Disulfide Reductase*/chemistry
Thioredoxin-Disulfide Reductase*/genetics
Thioredoxin-Disulfide Reductase*/metabolism
Antioxidants/metabolism ; Antioxidants/pharmacology ; Bacterial Proteins/metabolism ; Heat-Shock Proteins/metabolism ; Proteome/metabolism ; Proteomics ; Radiation, Ionizing
Czasopismo naukowe
Szczegóły
Tytuł:
Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases.
Autorzy:
Gencheva R; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden.
Cheng Q; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden.
Arnér ESJ; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden; Department of Selenoprotein Research, National Tumor Biology Laboratory, National Institute of Oncology, 1122, Budapest, Hungary. Electronic address: .
Pokaż więcej
Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2022 Sep; Vol. 190, pp. 320-338. Date of Electronic Publication: 2022 Aug 17.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms*/drug therapy
Thioredoxin-Disulfide Reductase*
Humans ; Selenocysteine/chemistry ; Selenoproteins/chemistry ; Tumor Microenvironment
Czasopismo naukowe
Szczegóły
Tytuł:
A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production.
Autorzy:
Ding Q; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang H; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang Y; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
Lu Y; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
Pokaż więcej
Źródło:
Molecular biology reports [Mol Biol Rep] 2022 Sep; Vol. 49 (9), pp. 8835-8845. Date of Electronic Publication: 2022 Jul 02.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Neoplasms*/metabolism
Thioredoxin Reductase 1*/metabolism
A549 Cells ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Humans ; Phenazines/pharmacology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.
Autorzy:
Dou Q; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Turanov AA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mariotti M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Genetics, Microbiology and Statistics, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Hwang JY; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA.
Wang H; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA.
Lee SG; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Yim SH; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Chung JJ; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA; Department of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut, USA.
Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102183. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Proteomics*
Semen*/metabolism
Thioredoxin-Disulfide Reductase/*metabolism
Animals ; Fertility ; Male ; Mice ; Oxidation-Reduction ; Selenoproteins ; Spermatogenesis ; Sulfhydryl Compounds ; Thioredoxin-Disulfide Reductase/genetics ; Thioredoxins/genetics ; Thioredoxins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Targeting thioredoxin reductase by micheliolide contributes to radiosensitizing and inducing apoptosis of HeLa cells.
Autorzy:
Zhang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, And College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Chen Y; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, And College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China; Key Laboratory of Space Radiobiology of Gansu Province & CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine, And Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Fang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, And College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China; School of Chemistry and Chemical Engineering, Nanjing University of Science & Technology, Nanjing, 210094, China. Electronic address: .
Pokaż więcej
Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2022 Jun; Vol. 186, pp. 99-109. Date of Electronic Publication: 2022 May 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
Thioredoxin-Disulfide Reductase*/metabolism
Adult ; Apoptosis ; HeLa Cells ; Humans ; Prospective Studies ; Reactive Oxygen Species/metabolism ; Sesquiterpenes, Guaiane
Czasopismo naukowe
Szczegóły
Tytuł:
Flux versus poise: Measuring the dynamic cellular activity of the thioredoxin system with a redox probe.
Autorzy:
Hondal RJ; University of Vermont, Department of Biochemistry, 89 Beaumont Ave, Given Bldg, Room B413, Burlington, VT, 05405, USA. Electronic address: .
Pokaż więcej
Źródło:
Redox biology [Redox Biol] 2022 Aug; Vol. 54, pp. 102376. Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin-Disulfide Reductase*
Thioredoxins*/metabolism
Oxidation-Reduction
Czasopismo naukowe
Szczegóły
Tytuł:
Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.
Autorzy:
Santesmasses D; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Pokaż więcej
Źródło:
Biomolecules [Biomolecules] 2022 Jul 28; Vol. 12 (8). Date of Electronic Publication: 2022 Jul 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Selenium*/metabolism
Selenocysteine*/genetics
Selenocysteine*/metabolism
Peroxiredoxin VI/*metabolism
Phospholipid Hydroperoxide Glutathione Peroxidase/*metabolism
Stearoyl-CoA Desaturase/*metabolism
Thioredoxin Reductase 1/*metabolism
Cell Line ; Genome, Human ; Humans ; Peroxiredoxin VI/genetics ; Selenoproteins/genetics ; Selenoproteins/metabolism ; Thioredoxin Reductase 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Thioredoxin Reductase 1 Modulates Pigmentation and Photobiology of Murine Melanocytes in vivo.
Autorzy:
Carpenter EL; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA.
Wyant MB; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA.
Indra A; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Corvallis High School, Corvallis, Oregon, USA.
Ito S; Institute for Melanin Chemistry, Fujita Health University, Toyoake, Aichi, Japan.
Wakamatsu K; Institute for Melanin Chemistry, Fujita Health University, Toyoake, Aichi, Japan.
Merrill GF; Department of Biochemistry and Biophysics, College of Science, Oregon State University, Corvallis, Oregon, USA.
Moos PJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.
Cassidy PB; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Leachman SA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Ganguli-Indra G; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Indra AK; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Department of Biochemistry and Biophysics, College of Science, Oregon State University, Corvallis, Oregon, USA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of investigative dermatology [J Invest Dermatol] 2022 Jul; Vol. 142 (7), pp. 1903-1911.e5. Date of Electronic Publication: 2022 Jan 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Photobiology*
Thioredoxin Reductase 1*/genetics
Animals ; Antioxidants/pharmacology ; Melanocytes/radiation effects ; Mice ; Pigmentation ; Ultraviolet Rays
Czasopismo naukowe
Szczegóły
Tytuł:
Expanding the armory for treating lymphoma: Targeting redox cellular status through thioredoxin reductase inhibition.
Autorzy:
Wang S; School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia; Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia.
Di Trapani G; School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia. Electronic address: .
Tonissen KF; School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia; Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia. Electronic address: .
Pokaż więcej
Źródło:
Pharmacological research [Pharmacol Res] 2022 Mar; Vol. 177, pp. 106134. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Lymphoma*/drug therapy
Thioredoxin-Disulfide Reductase*/metabolism
Antioxidants/metabolism ; Antioxidants/therapeutic use ; Glutathione/metabolism ; Humans ; Oxidation-Reduction ; Thioredoxins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function.
Autorzy:
Chocron ES; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.; Department of Radiation Oncology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Mdaki K; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.
Jiang N; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.
Cropper J; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.
Pickering AM; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA. .; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. .
Pokaż więcej
Źródło:
Communications biology [Commun Biol] 2022 May 16; Vol. 5 (1), pp. 467. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Metabolic Diseases*/genetics
Metabolic Diseases*/metabolism
Thioredoxin Reductase 2*/genetics
Thioredoxin Reductase 2*/metabolism
Animals ; Citric Acid Cycle/physiology ; Electron Transport/physiology ; Mice ; Mitochondria/metabolism ; Oxidation-Reduction ; Thioredoxins/genetics ; Thioredoxins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo.
Autorzy:
Duan D; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China. Electronic address: .
Wang Y; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Pan D; Department of Medical Technology, Qiandongnan Vocational and Technical College for Nationalities, Kaili 556000, China.
Jin X; School of Pharmacy and Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Yan Y; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Song P; Affiliated Hospital of Gansu University of Chinese Medicine and Key Laboratory of Prevention and Treatment for Chronic Diseases by TCM, Gansu Province, Lanzhou 730000, China.
Wang L; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Xiao J; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Wang Z; Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China. Electronic address: .
Wang X; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China. Electronic address: .
Pokaż więcej
Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 May; Vol. 122, pp. 105711. Date of Electronic Publication: 2022 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Morphinans*/pharmacology
Thioredoxin-Disulfide Reductase*/antagonists & inhibitors
Uterine Cervical Neoplasms*/drug therapy
Antirheumatic Agents ; Apoptosis ; Drug Repositioning ; Female ; Humans ; Reactive Oxygen Species
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 19398

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies

Prześlij opinię

Twoje opinie są dla nas bardzo ważne i mogą być niezwykle pomocne w pokazaniu nam, gdzie możemy dokonać ulepszeń. Bylibyśmy bardzo wdzięczni za poświęcenie kilku chwil na wypełnienie krótkiego formularza.

Formularz