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Wyszukujesz frazę ""Thioredoxin"" wg kryterium: Temat


Tytuł:
Methionine restriction exposes a targetable redox vulnerability of triple-negative breast cancer cells by inducing thioredoxin reductase.
Autorzy:
Malin D; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Lee Y; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Chepikova O; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.; Department of Biotechnology, Sirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia.
Strekalova E; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Carlson A; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Cryns VL; Department of Medicine, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA. .
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Źródło:
Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Dec; Vol. 190 (3), pp. 373-387. Date of Electronic Publication: 2021 Sep 22.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin-Disulfide Reductase*/genetics
Thioredoxin-Disulfide Reductase*/metabolism
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Animals ; Auranofin/pharmacology ; Humans ; Methionine/metabolism ; Mice ; Oxidation-Reduction ; Thioredoxin Reductase 1/genetics ; Thioredoxin Reductase 1/metabolism
Czasopismo naukowe
Tytuł:
Synthesis and discovery of Baylis-Hillman adducts as potent and selective thioredoxin reductase inhibitors for cancer treatment.
Autorzy:
He YL; Natural Medicine Research & Development Center, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Zhong M; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Song ZL; Natural Medicine Research & Development Center, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
Shen YK; Lizhi College, Xi'an Jiaotong University, No. 28, Xianning West Road, Xi'an, Shaanxi 710049, China.
Zhao L; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of the Chinese Academy of Sciences, Hangzhou 310024, China. Electronic address: .
Fang J; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Feb 01; Vol. 79, pp. 117169. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin-Disulfide Reductase*/metabolism
Neoplasms*/drug therapy
Humans ; Oxidative Stress ; Oxidation-Reduction
Czasopismo naukowe
Tytuł:
Menadione inhibits thioredoxin reductase 1 via arylation at the Sec substitution.
Autorzy:
Sun S; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Xu W; School of Ocean Science and Technology (OST) & Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), Dalian University of Technology, Panjin 124221, China.
Zhang Y; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Yang Y; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Ma Q; Chinese Academy of Inspection and Quarantine, Beijing 100176, China. Electronic address: .
Xu J; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China. Electronic address: .
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Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2021 Aug 20; Vol. 172, pp. 482-489. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Thioredoxin Reductase 1*/genetics
Thioredoxin Reductase 1*/metabolism
Vitamin K 3*/pharmacology
NADP ; Oxidation-Reduction ; Superoxides ; Thioredoxin-Disulfide Reductase/genetics ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł:
A novel thioredoxin glutathione reductase from evolutionary ancient metazoan Hydra.
Autorzy:
Perween N; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India; Department of Zoology, M. C. E. Society's Abeda Inamdar Senior College, Pune, 411001, India.
Pekhale K; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India.
Haval G; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India; Department of Zoology, Abasaheb Garware College, Pune, 411004, India.
Mittal S; Department of Biotechnology, Savitribai Phule Pune University, Pune, 411007, India.
Ghaskadbi S; Developmental Biology Group, MACS-Agharkar Research Institute, Pune, 411004, India.
Ghaskadbi SS; Department of Zoology, Savitribai Phule Pune University, Pune, 411007, India. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 31; Vol. 637, pp. 23-31. Date of Electronic Publication: 2022 Nov 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Thioredoxin-Disulfide Reductase*/genetics
Thioredoxin-Disulfide Reductase*/metabolism
Hydra*/genetics
Hydra*/metabolism
Animals ; Humans ; Glutathione Reductase/genetics ; Glutathione Reductase/metabolism ; Selenocysteine/chemistry ; Selenocysteine/metabolism ; Glutathione Disulfide/metabolism ; Hydrogen Peroxide ; Phylogeny ; Dinitrochlorobenzene ; HEK293 Cells ; Glutathione/metabolism ; Thioredoxins/genetics ; Thioredoxins/metabolism ; Oxidation-Reduction ; Antioxidants/metabolism ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells.
Autorzy:
Yang R; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Sun S; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Guo Y; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Meng Y; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Liu H; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Shi M; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
Guan S; State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, China.; Research & Educational Center for the Control Engineering of Translational Precision Medicine, School of Biomedical Engineering, Dalian University of Technology, Dalian 116024, China.
Xu J; School of Life and Pharmaceutical Sciences (LPS), Panjin Institute of Industrial Technology (PIIT), Liaoning Key Laboratory of Chemical Additive Synthesis and Separation, Dalian University of Technology, Panjin 124221, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 23; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Dimethyl Fumarate*/pharmacology
Dimethyl Fumarate*/chemistry
Thioredoxin Reductase 1*/metabolism
Mice ; Animals ; RAW 264.7 Cells ; Inflammation/drug therapy ; Cytokines ; Anti-Inflammatory Agents/pharmacology ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Tytuł:
Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma.
Autorzy:
Kalın ŞN; Atatürk University, Science Faculty, Department of Molecular Biology and Genetics, 25240 Erzurum, Türkiye; Atatürk University, East Anatolia High Technology Application and Research Center, 25240 Erzurum, Turkey.
Altay A; Erzincan Binali Yıldırım University, Faculty of Science and Arts, Department of Chemistry, 24002 Erzincan, Turkey.
Budak H; Atatürk University, Science Faculty, Department of Molecular Biology and Genetics, 25240 Erzurum, Türkiye. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2022 Dec 01; Vol. 310, pp. 121093. Date of Electronic Publication: 2022 Oct 18.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin Reductase 1*
Breast Neoplasms*/pathology
Humans ; Female ; Carboplatin/pharmacology ; Carboplatin/therapeutic use ; MCF-7 Cells ; Apoptosis ; Cell Proliferation ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors.
Autorzy:
Zhou J; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Yu LZ; School of Pharmacy, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Fan YL; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Guo CH; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Lv XM; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Zhou ZY; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Huang HD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Miao DD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Zhang SP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
Li XY; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
Zhao PP; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
Liu XP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
Hu WH; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
Zhang C; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114860. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase*/antagonists & inhibitors
Reactive Oxygen Species*
Thioredoxin Reductase 1*/antagonists & inhibitors
Colorectal Neoplasms*/enzymology
Cell Line, Tumor ; Humans ; Apoptosis/drug effects
Czasopismo naukowe
Tytuł:
Targeted inhibition of TXNRD1 prevents cartilage extracellular matrix degeneration by activating Nrf2 pathway in osteoarthritis.
Autorzy:
Liang J; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Wang S; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Hu J; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Hong X; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Zhu M; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Liu X; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Alswadeh M; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China.
Mo F; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China. Electronic address: .
Dai M; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, China. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Dec 20; Vol. 635, pp. 267-276. Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cartilage, Articular*/metabolism
Osteoarthritis*/metabolism
Thioredoxin Reductase 1*/genetics
Animals ; Mice ; Auranofin/pharmacology ; Chondrocytes/metabolism ; Extracellular Matrix/metabolism ; Interleukin-1beta/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Tytuł:
Revealing PACMA 31 as a new chemical type TrxR inhibitor to promote cancer cell apoptosis.
Autorzy:
Xu Q; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Zhang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.. Electronic address: .
Zhao Z; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Chu Y; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Fang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.. Electronic address: .
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Źródło:
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Oct; Vol. 1869 (10), pp. 119323. Date of Electronic Publication: 2022 Jul 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms*/drug therapy
Thioredoxin-Disulfide Reductase*/metabolism
Thioredoxin-Disulfide Reductase*/pharmacology
Intracellular Signaling Peptides and Proteins/*metabolism
Apoptosis ; Enzyme Inhibitors/pharmacology ; Humans ; Molecular Docking Simulation ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł:
Proteomic profiling of Deinococcus radiodurans with response to thioredoxin reductase inhibitor and ionizing radiation treatment.
Autorzy:
M S; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India.
N RP; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India.
Chakraborty A; UGC-DAE Consortium for Scientific Research, Kolkata Centre, 700098, West Bengal, India.
Rajendrasozhan S; Department of Chemistry, College of Science, University of Hail, Hail, Saudi Arabia.
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Źródło:
Journal of proteomics [J Proteomics] 2022 Sep 15; Vol. 267, pp. 104697. Date of Electronic Publication: 2022 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deinococcus*/genetics
Deinococcus*/metabolism
Deinococcus*/radiation effects
Thioredoxin-Disulfide Reductase*/chemistry
Thioredoxin-Disulfide Reductase*/genetics
Thioredoxin-Disulfide Reductase*/metabolism
Antioxidants/metabolism ; Antioxidants/pharmacology ; Bacterial Proteins/metabolism ; Heat-Shock Proteins/metabolism ; Proteome/metabolism ; Proteomics ; Radiation, Ionizing
Czasopismo naukowe
Tytuł:
Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases.
Autorzy:
Gencheva R; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden.
Cheng Q; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden.
Arnér ESJ; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden; Department of Selenoprotein Research, National Tumor Biology Laboratory, National Institute of Oncology, 1122, Budapest, Hungary. Electronic address: .
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Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2022 Sep; Vol. 190, pp. 320-338. Date of Electronic Publication: 2022 Aug 17.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms*/drug therapy
Thioredoxin-Disulfide Reductase*
Humans ; Selenocysteine/chemistry ; Selenoproteins/chemistry ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production.
Autorzy:
Ding Q; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang H; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang Y; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
Lu Y; Department of Marine Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. .
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Źródło:
Molecular biology reports [Mol Biol Rep] 2022 Sep; Vol. 49 (9), pp. 8835-8845. Date of Electronic Publication: 2022 Jul 02.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Neoplasms*/metabolism
Thioredoxin Reductase 1*/metabolism
A549 Cells ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Humans ; Phenazines/pharmacology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.
Autorzy:
Dou Q; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Turanov AA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mariotti M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Genetics, Microbiology and Statistics, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Hwang JY; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA.
Wang H; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA.
Lee SG; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Yim SH; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Chung JJ; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA; Department of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut, USA.
Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102183. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Proteomics*
Semen*/metabolism
Thioredoxin-Disulfide Reductase/*metabolism
Animals ; Fertility ; Male ; Mice ; Oxidation-Reduction ; Selenoproteins ; Spermatogenesis ; Sulfhydryl Compounds ; Thioredoxin-Disulfide Reductase/genetics ; Thioredoxins/genetics ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł:
Targeting thioredoxin reductase by micheliolide contributes to radiosensitizing and inducing apoptosis of HeLa cells.
Autorzy:
Zhang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, And College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Chen Y; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, And College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China; Key Laboratory of Space Radiobiology of Gansu Province & CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine, And Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Fang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, And College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China; School of Chemistry and Chemical Engineering, Nanjing University of Science & Technology, Nanjing, 210094, China. Electronic address: .
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Źródło:
Free radical biology & medicine [Free Radic Biol Med] 2022 Jun; Vol. 186, pp. 99-109. Date of Electronic Publication: 2022 May 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
Thioredoxin-Disulfide Reductase*/metabolism
Adult ; Apoptosis ; HeLa Cells ; Humans ; Prospective Studies ; Reactive Oxygen Species/metabolism ; Sesquiterpenes, Guaiane
Czasopismo naukowe
Tytuł:
Flux versus poise: Measuring the dynamic cellular activity of the thioredoxin system with a redox probe.
Autorzy:
Hondal RJ; University of Vermont, Department of Biochemistry, 89 Beaumont Ave, Given Bldg, Room B413, Burlington, VT, 05405, USA. Electronic address: .
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Źródło:
Redox biology [Redox Biol] 2022 Aug; Vol. 54, pp. 102376. Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Thioredoxin-Disulfide Reductase*
Thioredoxins*/metabolism
Oxidation-Reduction
Czasopismo naukowe
Tytuł:
Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.
Autorzy:
Santesmasses D; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Jul 28; Vol. 12 (8). Date of Electronic Publication: 2022 Jul 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Selenium*/metabolism
Selenocysteine*/genetics
Selenocysteine*/metabolism
Peroxiredoxin VI/*metabolism
Phospholipid Hydroperoxide Glutathione Peroxidase/*metabolism
Stearoyl-CoA Desaturase/*metabolism
Thioredoxin Reductase 1/*metabolism
Cell Line ; Genome, Human ; Humans ; Peroxiredoxin VI/genetics ; Selenoproteins/genetics ; Selenoproteins/metabolism ; Thioredoxin Reductase 1/genetics
Czasopismo naukowe
Tytuł:
Thioredoxin Reductase 1 Modulates Pigmentation and Photobiology of Murine Melanocytes in vivo.
Autorzy:
Carpenter EL; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA.
Wyant MB; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA.
Indra A; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Corvallis High School, Corvallis, Oregon, USA.
Ito S; Institute for Melanin Chemistry, Fujita Health University, Toyoake, Aichi, Japan.
Wakamatsu K; Institute for Melanin Chemistry, Fujita Health University, Toyoake, Aichi, Japan.
Merrill GF; Department of Biochemistry and Biophysics, College of Science, Oregon State University, Corvallis, Oregon, USA.
Moos PJ; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.
Cassidy PB; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Leachman SA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Ganguli-Indra G; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Indra AK; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Department of Biochemistry and Biophysics, College of Science, Oregon State University, Corvallis, Oregon, USA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA. Electronic address: .
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Źródło:
The Journal of investigative dermatology [J Invest Dermatol] 2022 Jul; Vol. 142 (7), pp. 1903-1911.e5. Date of Electronic Publication: 2022 Jan 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Photobiology*
Thioredoxin Reductase 1*/genetics
Animals ; Antioxidants/pharmacology ; Melanocytes/radiation effects ; Mice ; Pigmentation ; Ultraviolet Rays
Czasopismo naukowe
Tytuł:
Expanding the armory for treating lymphoma: Targeting redox cellular status through thioredoxin reductase inhibition.
Autorzy:
Wang S; School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia; Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia.
Di Trapani G; School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia. Electronic address: .
Tonissen KF; School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia; Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia. Electronic address: .
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Źródło:
Pharmacological research [Pharmacol Res] 2022 Mar; Vol. 177, pp. 106134. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Lymphoma*/drug therapy
Thioredoxin-Disulfide Reductase*/metabolism
Antioxidants/metabolism ; Antioxidants/therapeutic use ; Glutathione/metabolism ; Humans ; Oxidation-Reduction ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł:
Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function.
Autorzy:
Chocron ES; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.; Department of Radiation Oncology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Mdaki K; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.
Jiang N; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.
Cropper J; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.
Pickering AM; Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA. .; Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 May 16; Vol. 5 (1), pp. 467. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Metabolic Diseases*/genetics
Metabolic Diseases*/metabolism
Thioredoxin Reductase 2*/genetics
Thioredoxin Reductase 2*/metabolism
Animals ; Citric Acid Cycle/physiology ; Electron Transport/physiology ; Mice ; Mitochondria/metabolism ; Oxidation-Reduction ; Thioredoxins/genetics ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł:
Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo.
Autorzy:
Duan D; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China. Electronic address: .
Wang Y; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Pan D; Department of Medical Technology, Qiandongnan Vocational and Technical College for Nationalities, Kaili 556000, China.
Jin X; School of Pharmacy and Gansu University Key Laboratory for Molecular Medicine & Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Yan Y; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Song P; Affiliated Hospital of Gansu University of Chinese Medicine and Key Laboratory of Prevention and Treatment for Chronic Diseases by TCM, Gansu Province, Lanzhou 730000, China.
Wang L; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Xiao J; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China.
Wang Z; Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China. Electronic address: .
Wang X; Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China. Electronic address: .
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Źródło:
Bioorganic chemistry [Bioorg Chem] 2022 May; Vol. 122, pp. 105711. Date of Electronic Publication: 2022 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Morphinans*/pharmacology
Thioredoxin-Disulfide Reductase*/antagonists & inhibitors
Uterine Cervical Neoplasms*/drug therapy
Antirheumatic Agents ; Apoptosis ; Drug Repositioning ; Female ; Humans ; Reactive Oxygen Species
Czasopismo naukowe

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