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Tytuł :
Menadione inhibits thioredoxin reductase 1 via arylation at the Sec substitution.
Autorzy :
Sun S; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Xu W; School of Ocean Science and Technology (OST) & Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), Dalian University of Technology, Panjin 124221, China.
Zhang Y; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Yang Y; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China.
Ma Q; Chinese Academy of Inspection and Quarantine, Beijing 100176, China. Electronic address: .
Xu J; School of Life and Pharmaceutical Sciences (LPS) & Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin 124221, China. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Aug 20; Vol. 172, pp. 482-489. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Thioredoxin Reductase 1*/genetics
Thioredoxin Reductase 1*/metabolism
Vitamin K 3*/pharmacology
NADP ; Oxidation-Reduction ; Superoxides ; Thioredoxin-Disulfide Reductase/genetics ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł :
Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages.
Autorzy :
Staples S; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Wall SB; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Li R; Neonatal Redox Biology Laboratory, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Tipple TE; Center for Pregnancy and Newborn Research, Section of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Oklahoma College of Medicine, Oklahoma City, OK, USA. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118285. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Auranofin/*pharmacology
Macrophages, Alveolar/*metabolism
Thioredoxin Reductase 1/*metabolism
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Auranofin/metabolism ; Bronchopulmonary Dysplasia/metabolism ; Bronchopulmonary Dysplasia/physiopathology ; Glutathione/metabolism ; Interleukin-1beta/drug effects ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Lung/metabolism ; Macrophages/metabolism ; Macrophages, Alveolar/physiology ; Mice ; Primary Cell Culture ; Selenium/metabolism ; Selenium/pharmacology ; Thioredoxin Reductase 1/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł :
Thioredoxin reductase inhibitors: updated patent review (2017-present).
Autorzy :
Chupakhin E; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg Russian Federation.; Institute for Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad Russian Federation.
Krasavin M; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg Russian Federation.; Institute for Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad Russian Federation.
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Źródło :
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2021 Aug; Vol. 31 (8), pp. 745-758. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Animals ; Drug Development ; Humans ; Neoplasms/drug therapy ; Oxidative Stress/drug effects ; Patents as Topic ; Thioredoxin-Disulfide Reductase/metabolism ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
Thioredoxin-dependent system. Application of inhibitors.
Autorzy :
Jastrząb A; Department of Inorganic and Analytical Chemistry, Medical University of Bialystok, Bialystok, Poland.
Skrzydlewska E; Department of Inorganic and Analytical Chemistry, Medical University of Bialystok, Bialystok, Poland.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 362-371.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Enzyme Inhibitors/*therapeutic use
Neoplasms/*drug therapy
Neovascularization, Pathologic/*drug therapy
Thioredoxin-Disulfide Reductase/*genetics
Thioredoxins/*genetics
Antineoplastic Agents/chemical synthesis ; Benzene Derivatives/chemistry ; Benzene Derivatives/pharmacology ; Enzyme Inhibitors/chemical synthesis ; Gene Expression Regulation, Neoplastic ; Homeostasis/drug effects ; Homeostasis/genetics ; Humans ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Isoindoles/chemistry ; Isoindoles/pharmacology ; MAP Kinase Kinase Kinase 5/genetics ; MAP Kinase Kinase Kinase 5/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/pathology ; Neovascularization, Pathologic/enzymology ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Nitrosourea Compounds/chemistry ; Nitrosourea Compounds/pharmacology ; Organoselenium Compounds/chemistry ; Organoselenium Compounds/pharmacology ; Oxidation-Reduction ; Signal Transduction ; Structure-Activity Relationship ; Thioredoxin-Disulfide Reductase/antagonists & inhibitors ; Thioredoxin-Disulfide Reductase/metabolism ; Thioredoxins/antagonists & inhibitors ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
Onopordopicrin from the new genus Shangwua as a novel thioredoxin reductase inhibitor to induce oxidative stress-mediated tumor cell apoptosis.
Autorzy :
Zhang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Zheng ZQ; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Xu Q; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Li Y; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Gao K; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
Fang J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 790-801.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Asteraceae/*chemistry
Enzyme Inhibitors/*pharmacology
Lactones/*pharmacology
Sesquiterpenes/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Humans ; Lactones/chemistry ; Lactones/isolation & purification ; Molecular Docking Simulation ; Molecular Structure ; Oxidative Stress/drug effects ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Structure-Activity Relationship ; Thioredoxin-Disulfide Reductase/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
miR‑875‑5p regulates IR and inflammation via targeting TXNRD1 in gestational diabetes rats.
Autorzy :
Fu S; Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Fu S; Department of Respiration, The First Hospital of Lanzhou City, Lanzhou, Gansu 730050, P.R. China.
Ma X; Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Yang X; Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Ling J; Department of Pediatrics, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 May; Vol. 23 (5). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Diabetes, Gestational/*genetics
Inflammation/*genetics
Insulin Resistance/*genetics
MicroRNAs/*genetics
Thioredoxin Reductase 1/*genetics
Animals ; Blood Glucose/metabolism ; Cell Line, Tumor ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetes, Gestational/blood ; Diabetes, Gestational/metabolism ; Disease Models, Animal ; Fasting/blood ; Female ; Humans ; Lipids/blood ; Male ; Pregnancy ; RNA Interference ; Rats, Wistar ; Thioredoxin Reductase 1/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of thioredoxin reductase (TrxR) triggers oxidative stress-induced apoptosis in filarial nematode Setaria cervi channelized through ASK-1-p38 mediated caspase activation.
Autorzy :
Joardar N; Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati, Santiniketan, 731235, West Bengal, India.
Sen A; Applied Phycology Laboratory, Department of Botany, Siksha-Bhavana, Visva-Bharati, Santiniketan, 731235, West Bengal, India.
Rath J; Applied Phycology Laboratory, Department of Botany, Siksha-Bhavana, Visva-Bharati, Santiniketan, 731235, West Bengal, India.
Babu SPS; Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati, Santiniketan, 731235, West Bengal, India. Electronic address: .
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Źródło :
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2021 Mar; Vol. 242, pp. 111364. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anthelmintics/*pharmacology
Auranofin/*pharmacology
Caspases/*genetics
Curcumin/*pharmacology
Dinitrochlorobenzene/*pharmacology
Setaria Nematode/*drug effects
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Animals ; Anthelmintics/chemistry ; Apoptosis/drug effects ; Apoptosis/genetics ; Auranofin/chemistry ; Binding Sites ; Caspases/metabolism ; Cattle ; Curcumin/chemistry ; Dinitrochlorobenzene/chemistry ; Gene Expression Regulation ; Helminth Proteins/genetics ; Helminth Proteins/metabolism ; MAP Kinase Kinase Kinase 5/genetics ; MAP Kinase Kinase Kinase 5/metabolism ; Microfilariae/drug effects ; Microfilariae/enzymology ; Microfilariae/growth & development ; Models, Molecular ; Oxidative Stress ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Reactive Oxygen Species/agonists ; Reactive Oxygen Species/metabolism ; Setaria Nematode/enzymology ; Setaria Nematode/growth & development ; Signal Transduction ; Thioredoxin-Disulfide Reductase/chemistry ; Thioredoxin-Disulfide Reductase/genetics ; Thioredoxin-Disulfide Reductase/metabolism ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Evaluation of enzymatic activity of Babesia microti thioredoxin reductase (Bmi TrxR)-mutants and screening of its potential inhibitors.
Autorzy :
Lu J; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Wei N; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Cao J; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Zhou Y; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Gong H; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Zhang H; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China. Electronic address: .
Zhou J; Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China. Electronic address: .
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Źródło :
Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2021 Mar; Vol. 12 (2), pp. 101623. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Babesia microti/*enzymology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Thioredoxin-Disulfide Reductase/*genetics
Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł :
The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity.
Autorzy :
Kameritsch P; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.
Singer M; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.
Nuernbergk C; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.
Rios N; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.; Centro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.
Reyes AM; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.; Centro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.
Schmidt K; Institute of Physiology, University of Lübeck, 23562 Lübeck, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Centre for Cardiovascular Research, 23562 Lübeck, Germany.
Kirsch J; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.
Schneider H; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.
Müller S; Institute of Pathology, Ludwig Maximilians-University, 80337 Munich, Germany.
Pogoda K; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.
Cui R; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.
Kirchner T; Institute of Pathology, Ludwig Maximilians-University, 80337 Munich, Germany.
de Wit C; Institute of Physiology, University of Lübeck, 23562 Lübeck, Germany.; Partner Site Hamburg/Kiel/Lübeck, German Centre for Cardiovascular Research, 23562 Lübeck, Germany.
Lange-Sperandio B; Department of Pediatrics, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians-University, 80337 Munich, Germany.
Pohl U; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany.; German Centre for Cardiovascular Research, Munich Heart Alliance, 80802 Munich, Germany.
Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, 85764 Neuherberg, Germany.; Laboratory of Experimental Oncology, National Research Medical University, Moscow 117997, Russia.
Radi R; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay; .; Centro de Investigaciones Biomédicas, Facultad de Medicina, Universidad de la República, 11800 Montevideo, Uruguay.
Beck H; Walter Brendel Centre of Experimental Medicine, Biomedical Center Munich, Ludwig-Maximilians-University, 82152 Planegg, Germany; .; German Centre for Cardiovascular Research, Munich Heart Alliance, 80802 Munich, Germany.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 16; Vol. 118 (7).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*metabolism
Peroxynitrous Acid/*metabolism
Thioredoxin Reductase 2/*metabolism
Animals ; Kidney/blood supply ; Kidney/metabolism ; Mice ; Mitochondria/metabolism ; Nitric Oxide/metabolism ; Oxidative Stress ; Thioredoxin Reductase 2/genetics ; Vascular Remodeling
Czasopismo naukowe
Tytuł :
Synthesis of mitochondria-targeted coumarin-3-carboxamide fluorescent derivatives: Inhibiting mitochondrial TrxR2 and cell proliferation on breast cancer cells.
Autorzy :
Li Y; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Tang Q; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Xie Y; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
He D; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Yang K; School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Zheng L; School of Pharmacy, Lanzhou University, Lanzhou 730000, China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Feb 01; Vol. 33, pp. 127750. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Coumarins/*pharmacology
Fluorescent Dyes/*pharmacology
Mitochondria/*drug effects
Thioredoxin Reductase 2/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Humans ; Mitochondria/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Thioredoxin Reductase 2/metabolism
Czasopismo naukowe
Tytuł :
Effects of Mammalian Thioredoxin Reductase Inhibitors.
Autorzy :
Arnér ESJ; Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. .; Department of Selenoprotein Research, National Institute of Oncology, Budapest, Hungary. .
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Źródło :
Handbook of experimental pharmacology [Handb Exp Pharmacol] 2021; Vol. 264, pp. 289-309.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants*
Thioredoxin-Disulfide Reductase*/metabolism
Animals ; Oxidation-Reduction ; Reactive Oxygen Species ; Signal Transduction
Czasopismo naukowe
Tytuł :
miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2.
Autorzy :
Bu L; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, China.; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Tian Y; Department of Geriatric Respiratory, Shaanxi Provincial People's Hospital, Xi'an 710068, China.
Wen H; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, China.
Jia W; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an 710018, China.
Yang S; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2021 Feb 04; Vol. 53 (2), pp. 189-200.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
RNA, Neoplasm/*metabolism
Thioredoxin Reductase 2/*metabolism
A549 Cells ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; RNA, Neoplasm/genetics ; Thioredoxin Reductase 2/genetics
Czasopismo naukowe
Tytuł :
A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites.
Autorzy :
Cobb DW; Department of Cellular Biology, University of Georgia, Georgia, United States of America.; Center for Tropical and Emerging Global Diseases, University of Georgia, Georgia, United States of America.
Kudyba HM; Department of Cellular Biology, University of Georgia, Georgia, United States of America.; Center for Tropical and Emerging Global Diseases, University of Georgia, Georgia, United States of America.
Villegas A; Department of Cellular Biology, University of Georgia, Georgia, United States of America.; Center for Tropical and Emerging Global Diseases, University of Georgia, Georgia, United States of America.
Hoopmann MR; Institute for Systems Biology, Seattle, Washington, United States of America.
Baptista RP; Center for Tropical and Emerging Global Diseases, University of Georgia, Georgia, United States of America.; Institute of Bioinformatics, University of Georgia, Georgia, United States of America.
Bruton B; Department of Cellular Biology, University of Georgia, Georgia, United States of America.
Krakowiak M; Department of Cellular Biology, University of Georgia, Georgia, United States of America.; Center for Tropical and Emerging Global Diseases, University of Georgia, Georgia, United States of America.
Moritz RL; Institute for Systems Biology, Seattle, Washington, United States of America.
Muralidharan V; Department of Cellular Biology, University of Georgia, Georgia, United States of America.; Center for Tropical and Emerging Global Diseases, University of Georgia, Georgia, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Feb 03; Vol. 17 (2), pp. e1009293. Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoplasmic Reticulum/*parasitology
HSP40 Heat-Shock Proteins/*metabolism
Malaria, Falciparum/*parasitology
Plasmodium falciparum/*physiology
Protozoan Proteins/*metabolism
Small Molecule Libraries/*pharmacology
Thioredoxin Reductase 2/*metabolism
Antimalarials/pharmacology ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; HSP40 Heat-Shock Proteins/genetics ; Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/metabolism ; Molecular Chaperones ; Oxidation-Reduction ; Oxidative Stress ; Protein Folding ; Protozoan Proteins/genetics ; Thioredoxin Reductase 2/genetics
Czasopismo naukowe
Tytuł :
Thiol antioxidant thioredoxin reductase: A prospective biochemical crossroads between anticancer and antiparasitic treatments of the modern era.
Autorzy :
Joardar N; Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati, Santiniketan 731235, West Bengal, India.
Guevara-Flores A; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510 Mexico City, Mexico. Electronic address: .
Martínez-González JJ; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510 Mexico City, Mexico.
Sinha Babu SP; Parasitology Laboratory, Department of Zoology, Siksha-Bhavana, Visva-Bharati, Santiniketan 731235, West Bengal, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 15; Vol. 165 (Pt A), pp. 249-267. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/therapeutic use
Antioxidants*
Antiparasitic Agents*/chemistry
Antiparasitic Agents*/therapeutic use
Drug Delivery Systems*
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/therapeutic use
Helminth Proteins/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Protozoan Proteins/*antagonists & inhibitors
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Animals ; Helminth Proteins/metabolism ; Humans ; Neoplasm Proteins/metabolism ; Protozoan Proteins/metabolism ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł :
Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity.
Autorzy :
Krasavin M; Saint Petersburg State University, Saint Petersburg, Russian Federation.
Sharonova T; Saint Petersburg State University, Saint Petersburg, Russian Federation.
Sharoyko V; Saint Petersburg State University, Saint Petersburg, Russian Federation.
Zhukovsky D; Saint Petersburg State University, Saint Petersburg, Russian Federation.
Kalinin S; Saint Petersburg State University, Saint Petersburg, Russian Federation.
Žalubovskis R; Latvian Institute of Organic Synthesis, Riga, Latvia.; Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia.
Tennikova T; Saint Petersburg State University, Saint Petersburg, Russian Federation.
Supuran CT; Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 665-671.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carbonic Anhydrases/*metabolism
Enzyme Inhibitors/*pharmacology
Sulfonamides/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Thioredoxin-Disulfide Reductase/metabolism
Czasopismo naukowe
Tytuł :
Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase.
Autorzy :
Krasavin M; Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Žalubovskis R; Latvian Institute of Organic Synthesis, Riga, Latvia.; Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia.
Grandāne A; Latvian Institute of Organic Synthesis, Riga, Latvia.
Domračeva I; Latvian Institute of Organic Synthesis, Riga, Latvia.
Zhmurov P; Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Supuran CT; Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 506-510.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrases/*metabolism
Coumarins/*pharmacology
Enzyme Inhibitors/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase IX/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship ; Thioredoxin-Disulfide Reductase/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Understanding the survival mechanisms of Deinococcus radiodurans against oxidative stress by targeting thioredoxin reductase redox system.
Autorzy :
Maqbool I; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, India.
Ponniresan VK; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, India.
Govindasamy K; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, India.; Dharumapurm Gnanambikai Government Arts College, Dharumapuram Road, Nagapattinam, Mayiladuthurai, Tamil Nadu, 609001, India.
Prasad NR; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, India. .
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Źródło :
Archives of microbiology [Arch Microbiol] 2020 Nov; Vol. 202 (9), pp. 2355-2366. Date of Electronic Publication: 2019 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*/drug effects
Deinococcus/*enzymology
Thioredoxin-Disulfide Reductase/*metabolism
Deinococcus/drug effects ; Deinococcus/growth & development ; Deinococcus/metabolism ; Hydrogen Peroxide/pharmacology ; Microbial Viability ; Reactive Oxygen Species/metabolism ; Thioredoxin-Disulfide Reductase/genetics
Czasopismo naukowe
Tytuł :
[Selenoprotein thioredoxin reductase mediated menadione reduction: catalytic properties & inhibition effects].
Autorzy :
Zhang N; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, Liaoning, China.; Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
Sun S; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, Liaoning, China.
Zhang Y; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, Liaoning, China.
Yang Y; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, Liaoning, China.
Zhang Y; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, Liaoning, China.
Chen J; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, Liaoning, China.
Xu W; School of Ocean Science and Technology (OST), Dalian University of Technology, Panjin 124221, Liaoning, China.
Ma Q; Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
Xu J; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, Liaoning, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2020 Oct 25; Vol. 36 (10), pp. 2139-2150.
Typ publikacji :
Journal Article
MeSH Terms :
Thioredoxin Reductase 1*/metabolism
Vitamin K 3*/chemistry
Vitamin K 3*/metabolism
Catalysis ; Drug Development ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor.
Autorzy :
Fan QZ; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui 241000, PR China.
Zhou J; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, PR China.
Zhu YB; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui 241000, PR China.
He LJ; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui 241000, PR China.
Miao DD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui 241000, PR China.
Zhang SP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui 241000, PR China.
Liu XP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui 241000, PR China. Electronic address: .
Zhang C; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui 241000, PR China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104401. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Dioxolanes/*pharmacology
Enzyme Inhibitors/*pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase/*antagonists & inhibitors
Thioredoxin Reductase 1/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dioxolanes/chemical synthesis ; Dioxolanes/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Molecular Structure ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Thioredoxin Reductase 1/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells.
Autorzy :
Meng C; The Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, People's Republic of China; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China.
Qian J; The Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, People's Republic of China; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China.
Xu Z; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China.
Liu J; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China.
Shan W; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China.
Zhu P; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China.
Zhu W; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China.
Miao J; The Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, People's Republic of China.
Ling CC; The Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, People's Republic of China; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China. Electronic address: .
Ling Y; The Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, People's Republic of China; School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, People's Republic of China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104360. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cyclohexenes/*pharmacology
Enzyme Inhibitors/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclohexenes/chemical synthesis ; Cyclohexenes/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Male ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Thioredoxin-Disulfide Reductase/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe

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