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Tytuł :
Molecular structure, NBO analysis of the hydrogen-bonded interactions, spectroscopic (FT-IR, FT-Raman), drug likeness and molecular docking of the novel anti COVID-2 molecule (2E)-N-methyl-2-[(4-oxo-4H-chromen-3-yl)methylidene]-hydrazinecarbothioamide (Dimer) - quantum chemical approach.
Autorzy :
Jenepha Mary SJ; Department of Physics and Research Centre, Scott Christian College (Autonomous), Nagercoil 629003, Tamil Nadu, Affiliated to Manonmaniam Sundarnar University, Abishekapatti, Tirunelveli 627012, India.
Pradhan S; Department of Chemistry, Jadavpur University, Kolkata 700 032, West Bengal, India.
James C; Department of Physics and Research Centre, Scott Christian College (Autonomous), Nagercoil 629003, Tamil Nadu, Affiliated to Manonmaniam Sundarnar University, Abishekapatti, Tirunelveli 627012, India. Electronic address: .
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Apr 15; Vol. 251, pp. 119388. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/analysis
Antiviral Agents*/chemical synthesis
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacokinetics
Chromones*/analysis
Chromones*/chemical synthesis
Chromones*/chemistry
Chromones*/pharmacokinetics
Drugs, Investigational*/analysis
Drugs, Investigational*/chemical synthesis
Drugs, Investigational*/chemistry
Drugs, Investigational*/pharmacokinetics
Thiourea*/analysis
Thiourea*/chemical synthesis
Thiourea*/chemistry
Thiourea*/pharmacokinetics
COVID-19/*drug therapy
Coronavirus 3C Proteases/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Computational Chemistry ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Humans ; Hydrazines/chemistry ; Hydrogen/chemistry ; Hydrogen Bonding ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Quantum Theory ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Thioamides/analysis ; Thioamides/chemical synthesis ; Thioamides/chemistry ; Thioamides/pharmacokinetics ; Vibration
Czasopismo naukowe
Tytuł :
Novel cyclic thiourea derivatives of aminoalcohols at the presence of AlCl 3 catalyst as potent α-glycosidase and α-amylase inhibitors: Synthesis, characterization, bioactivity investigation and molecular docking studies.
Autorzy :
Sujayev A; Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, 1029 Baku, Azerbaijan.
Taslimi P; Department of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, Turkey. Electronic address: .
Garibov E; Laboratory of Theoretical Bases of Synthesis and Action Mechanism of Additives, Institute of Chemistry of Additives, Azerbaijan National Academy of Sciences, 1029 Baku, Azerbaijan.
Karaman M; Department of Molecular Biology and Genetics, Faculty of Arts and Science, Kilis 7 Aralik University, 79100 Kilis, Turkey. Electronic address: .
Mahdi Zangeneh M; Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran; Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104216. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Aluminum Chloride/*chemistry
Amino Alcohols/*pharmacology
Glycoside Hydrolase Inhibitors/*pharmacology
Glycoside Hydrolases/*antagonists & inhibitors
Thiourea/*pharmacology
alpha-Amylases/*antagonists & inhibitors
Amino Alcohols/chemistry ; Catalysis ; Dose-Response Relationship, Drug ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolases/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Saccharomyces cerevisiae/enzymology ; Structure-Activity Relationship ; Thiourea/chemical synthesis ; Thiourea/chemistry ; alpha-Amylases/metabolism
Czasopismo naukowe
Tytuł :
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.
Autorzy :
Zhang Y; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Meng X; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Tang H; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Cheng M; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Yang F; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Xu W; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 344-353.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Enzyme Inhibitors/*pharmacology
Lung Neoplasms/*drug therapy
Proto-Oncogene Proteins p21(ras)/*antagonists & inhibitors
Thiourea/*pharmacology
A549 Cells ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Molecular Structure ; Proto-Oncogene Proteins p21(ras)/metabolism ; Structure-Activity Relationship ; Thiourea/chemical synthesis ; Thiourea/chemistry
Czasopismo naukowe
Tytuł :
Synthesis of benzoylthiourea derivatives and analysis of their antibacterial performance against planktonic Staphylococcus aureus and its biofilms.
Autorzy :
Pinheiro LCS; Drug Synthesis Department, Drug Technology Institute, Farmanguinhos - FIOCRUZ, Oswaldo Cruz Foundation, Manguinhos, RJ, Brazil.
Hoelz LVB; Drug Synthesis Department, Drug Technology Institute, Farmanguinhos - FIOCRUZ, Oswaldo Cruz Foundation, Manguinhos, RJ, Brazil.
Ferreira MLG; Drug Synthesis Department, Drug Technology Institute, Farmanguinhos - FIOCRUZ, Oswaldo Cruz Foundation, Manguinhos, RJ, Brazil.
Oliveira LG; Drug Synthesis Department, Drug Technology Institute, Farmanguinhos - FIOCRUZ, Oswaldo Cruz Foundation, Manguinhos, RJ, Brazil.
Pereira RFA; Laboratory of Molecular Epidemiology and Biotechnology/Rodolpho Albino University Laboratory, Fluminense Federal University, Niteroi, RJ, Brazil.; Postgraduate Program in Science and Biotechnology, Fluminense Federal University, Niteroi, RJ, Brazil.
do Valle AM; Laboratory of Molecular Epidemiology and Biotechnology/Rodolpho Albino University Laboratory, Fluminense Federal University, Niteroi, RJ, Brazil.
André LSP; Laboratory of Molecular Epidemiology and Biotechnology/Rodolpho Albino University Laboratory, Fluminense Federal University, Niteroi, RJ, Brazil.; Postgraduate Program in Pathology, Fluminense Federal University, Niteroi, RJ, Brazil.
Scaffo J; Laboratory of Molecular Epidemiology and Biotechnology/Rodolpho Albino University Laboratory, Fluminense Federal University, Niteroi, RJ, Brazil.
Pinheiro FR; Laboratory of Molecular Epidemiology and Biotechnology/Rodolpho Albino University Laboratory, Fluminense Federal University, Niteroi, RJ, Brazil.; Postgraduate Program in Applied Microbiology and Parasitology, Fluminense Federal University, Niterói, RJ, Brazil.
Ribeiro TAN; Institute of Physics and Chemistry, Federal University of Itajubá, Itajubá, MG, Brazil.
Sachs D; Institute of Physics and Chemistry, Federal University of Itajubá, Itajubá, MG, Brazil.
Pascoal ACRF; Department of Basic Sciences, Nova Friburgo Health Institute, Fluminense Federal University, Nova Friburgo, RJ, Brazil.
Boechat N; Drug Synthesis Department, Drug Technology Institute, Farmanguinhos - FIOCRUZ, Oswaldo Cruz Foundation, Manguinhos, RJ, Brazil.
Aguiar-Alves F; Laboratory of Molecular Epidemiology and Biotechnology/Rodolpho Albino University Laboratory, Fluminense Federal University, Niteroi, RJ, Brazil.; Postgraduate Program in Pathology, Fluminense Federal University, Niteroi, RJ, Brazil.; Postgraduate Program in Applied Microbiology and Parasitology, Fluminense Federal University, Niterói, RJ, Brazil.
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Źródło :
Letters in applied microbiology [Lett Appl Microbiol] 2020 Dec; Vol. 71 (6), pp. 645-651. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Biofilms/*drug effects
Staphylococcus aureus/*drug effects
Thiourea/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Humans ; Microbial Sensitivity Tests ; Plankton/drug effects ; Plankton/growth & development ; Plankton/physiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/growth & development ; Staphylococcus aureus/physiology ; Thiourea/chemistry
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of novel tetrahydrothieno [2,3-c]pyridine substitued benzoyl thiourea derivatives as PAK1 inhibitors in triple negative breast cancer.
Autorzy :
Yao D; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, China.; School of Pharmaceutical Sciences, Guangdong Key Laboratory for Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, China.
Huang J; Drug Development Department, Shenzhen Honghui Bio-Pharmaceutical Co. Ltd., Shenzhen, China.
Wang J; Drug Development Department, Shenzhen Honghui Bio-Pharmaceutical Co. Ltd., Shenzhen, China.
He Z; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, China.; School of Pharmaceutical Sciences, Guangdong Key Laboratory for Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, China.
Zhang J; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, China.; Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1524-1538.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Thiourea/*pharmacology
Triple Negative Breast Neoplasms/*drug therapy
p21-Activated Kinases/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; Thiourea/analogs & derivatives ; Thiourea/chemistry ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; p21-Activated Kinases/metabolism
Czasopismo naukowe
Tytuł :
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
Autorzy :
Ladds MJGW; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address: .
Popova G; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Pastor-Fernández A; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Kannan S; Bioinformatics Institute (BII), A*STAR, Singapore.
van Leeuwen IMM; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Håkansson M; SARomics Biostructures AB, Lund, Sweden.
Walse B; SARomics Biostructures AB, Lund, Sweden.
Tholander F; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Bhatia R; Division of Hematology and Oncology, O'Neal Comprehensive Cancer Center, University of Alabama, Birmingham, Alabama, USA.
Verma CS; Bioinformatics Institute (BII), A*STAR, Singapore; Department of Biological Sciences, National University of Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore.
Lane DP; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Laín S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; SciLifeLab, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 17935-17949. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polypharmacology*
Acetanilides/*pharmacology
Enzyme Inhibitors/*pharmacology
Neoplasms/*drug therapy
Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors
Sirtuin 1/*antagonists & inhibitors
Thiourea/*analogs & derivatives
Tumor Suppressor Protein p53/*metabolism
Autophagy ; Cell Proliferation ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Thiourea/pharmacology ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Cyclical aggregation extends in vitro expansion potential of human mesenchymal stem cells.
Autorzy :
Bijonowski BM; Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer St., Tallahassee, FL, 32310, USA. .; University of Münster, Münster, Germany. .
Yuan X; Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer St., Tallahassee, FL, 32310, USA.; The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.
Jeske R; Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer St., Tallahassee, FL, 32310, USA.
Li Y; Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer St., Tallahassee, FL, 32310, USA. .
Grant SC; Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer St., Tallahassee, FL, 32310, USA.; The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 24; Vol. 10 (1), pp. 20448. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adenine/*analogs & derivatives
Cell Culture Techniques/*methods
Cinnamates/*pharmacology
Indoles/*pharmacology
Mesenchymal Stem Cells/*cytology
Thiourea/*analogs & derivatives
Adenine/pharmacology ; Cell Aggregation/drug effects ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Cellular Senescence/drug effects ; Humans ; Surface Properties ; Thiourea/pharmacology
Czasopismo naukowe
Tytuł :
N,N'-Diphenylthiourea electrochemical sensor for the detection of l-glutamate and Aspartate in beef.
Autorzy :
Wang X; College of Food Science and Engineering, Jilin University, Changchun, P. R. China.
Hu F; College of Food Science and Engineering, Jilin University, Changchun, P. R. China.
Zhu L; College of Food Science and Engineering, Jilin University, Changchun, P. R. China.
Liu D; College of Food Science and Technology, Bohai University, Jinzhou, P. R. China.
Dong Y; College of Food Science and Engineering, Jilin University, Changchun, P. R. China.
Wang C; College of Food Science and Engineering, Jilin University, Changchun, P. R. China.
Wu D; College of Food Science and Engineering, Jilin University, Changchun, P. R. China.
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Źródło :
Journal of food science [J Food Sci] 2020 Nov; Vol. 85 (11), pp. 3852-3857. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Aspartic Acid/*analysis
Electrochemical Techniques/*methods
Glutamic Acid/*analysis
Red Meat/*analysis
Thiourea/*analogs & derivatives
Animals ; Cattle ; Reproducibility of Results ; Thiourea/analysis
Czasopismo naukowe
Tytuł :
Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies.
Autorzy :
Mumtaz A; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan. Electronic address: .
Saeed K; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Mahmood A; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Zaib S; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Saeed A; Department of Chemistry, Quaid-i-Azam University Islamabad, Pakistan.
Pelletier J; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC G1V 4G2, Canada.
Sévigny J; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC G1V 4G2, Canada; Département de Microbiologie-infectiologie et d'immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
Iqbal J; Center for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Aug; Vol. 101, pp. 103996. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkaline Phosphatase/*antagonists & inhibitors
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Intestines/*enzymology
Pimelic Acids/*chemistry
Salicylates/*chemistry
Thiourea/*pharmacology
Enzyme Inhibitors/chemical synthesis ; Hydrogen Bonding ; Molecular Docking Simulation ; Structure-Activity Relationship ; Thiourea/chemistry
Czasopismo naukowe
Tytuł :
Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors.
Autorzy :
Doğan ŞD; Department of Basic Sciences, Faculty of Pharmacy, Erciyes University, 38039, Kayseri, Turkey. Electronic address: .
Gündüz MG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Sıhhiye, 06100, Ankara, Turkey.
Doğan H; Department of Basic Sciences, Faculty of Pharmacy, Erciyes University, 38039, Kayseri, Turkey.
Krishna VS; Department of Pharmacy, Birla Institute of Technology and Science-Pilani, 500078, Hyderabad, India.
Lherbet C; LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118, route de Narbonne, 236 Cours Eugene Cosserat, 31062, Toulouse Cedex, France.
Sriram D; Department of Pharmacy, Birla Institute of Technology and Science-Pilani, 500078, Hyderabad, India.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Aug 01; Vol. 199, pp. 112402. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antitubercular Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Mycobacterium tuberculosis/*drug effects
Oxidoreductases/*antagonists & inhibitors
Thiourea/*pharmacology
Animals ; Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Bacterial Proteins/metabolism ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Macrophages/drug effects ; Macrophages/microbiology ; Mice ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Mycobacterium tuberculosis/growth & development ; Mycobacterium tuberculosis/metabolism ; Oxidoreductases/metabolism ; RAW 264.7 Cells ; Structure-Activity Relationship ; Thiourea/chemical synthesis ; Thiourea/chemistry
Czasopismo naukowe
Tytuł :
Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors.
Autorzy :
Hashem HE; Department of Chemistry, Faculty of Women, Ain Shams University, Heliopolis, Cairo 11457, Egypt.
Amr AEE; Drug Exploration & Development Chair (DEDC), Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.; Applied Organic Chemistry Department, National Research Center, Dokki 12622, Cairo, Egypt.
Nossier ES; Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.
Elsayed EA; Bioproducts Research Chair, Zoology Department, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia.; Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki 12622, Cairo, Egypt.
Azmy EM; Department of Chemistry, Faculty of Women, Ain Shams University, Heliopolis, Cairo 11457, Egypt.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 15; Vol. 25 (12). Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Topoisomerase IV/*antagonists & inhibitors
Thiourea/*pharmacology
Topoisomerase II Inhibitors/*chemistry
Anti-Bacterial Agents/pharmacology ; DNA Gyrase/chemistry ; DNA Topoisomerase IV/chemistry ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Structure-Activity Relationship ; Thiadiazoles/chemistry ; Thiadiazoles/pharmacology ; Thiourea/analogs & derivatives ; Thiourea/chemistry ; Triazines/chemistry ; Triazines/pharmacology
Czasopismo naukowe
Tytuł :
In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines.
Autorzy :
Nordin NA; Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Besut Campus, Terengganu, Malaysia.; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Sarawak, Malaysia.
Lawai V; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Sarawak, Malaysia.
Ngaini Z; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Sarawak, Malaysia.
Abd Halim AN; Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Sarawak, Malaysia.
Hwang SS; Faculty of Engineering, Computing and Science, Swinburne University of Technology Sarawak Campus, Sarawak, Malaysia.
Linton RE; Faculty of Engineering, Computing and Science, Swinburne University of Technology Sarawak Campus, Sarawak, Malaysia.
Lee BK; Faculty of Engineering, Computing and Science, Swinburne University of Technology Sarawak Campus, Sarawak, Malaysia.
Neilsen PM; School of Health Medical and Applied Sciences, Central Queensland University, Norman Gardens, Australia.
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Źródło :
Natural product research [Nat Prod Res] 2020 Jun; Vol. 34 (11), pp. 1505-1514. Date of Electronic Publication: 2018 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Thiourea/*toxicity
Aspirin/analogs & derivatives ; Aspirin/metabolism ; Cell Line, Tumor ; Cyclooxygenase 2/metabolism ; Halogens/chemistry ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Salix/chemistry ; Structure-Activity Relationship ; Thiourea/analogs & derivatives ; Thiourea/metabolism
Czasopismo naukowe
Tytuł :
Alternative methanogenesis - Methanogenic potential of organosulfur administration.
Autorzy :
Varga P; Institute of Surgical Research, University of Szeged, Szeged, Hungary.
Vida N; Institute of Surgical Research, University of Szeged, Szeged, Hungary.
Hartmann P; Institute of Surgical Research, University of Szeged, Szeged, Hungary.
Szabó A; MTA-SZTE Research Group on Photoacoustic Spectroscopy, University of Szeged, Szeged, Hungary.
Mohácsi Á; MTA-SZTE Research Group on Photoacoustic Spectroscopy, University of Szeged, Szeged, Hungary.
Szabó G; MTA-SZTE Research Group on Photoacoustic Spectroscopy, University of Szeged, Szeged, Hungary.
Boros M; Institute of Surgical Research, University of Szeged, Szeged, Hungary.
Tuboly E; Institute of Surgical Research, University of Szeged, Szeged, Hungary.
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Źródło :
PloS one [PLoS One] 2020 Jul 30; Vol. 15 (7), pp. e0236578. Date of Electronic Publication: 2020 Jul 30 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dimethyl Sulfoxide/*chemistry
Methane/*analysis
Thiourea/*analogs & derivatives
Animals ; Diet/veterinary ; Dimethyl Sulfoxide/pharmacology ; Ethanol/pharmacology ; Glutathione/metabolism ; Liver/diagnostic imaging ; Liver/metabolism ; Liver/pathology ; Male ; Methane/metabolism ; Mice ; Mice, Hairless ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/chemistry ; Reactive Oxygen Species/metabolism ; Sulfhydryl Compounds/analysis ; Thiourea/chemistry ; Thiourea/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study.
Autorzy :
Abbas SY; Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt. Electronic address: .
Al-Harbi RAK; Department of Chemistry, Faculty of Science, Taibah University, Almadinah Almunawarrah, Saudi Arabia.
Sh El-Sharief MAM; Applied Organic Chemistry Department, National Research Centre, Cairo, Egypt; Faculty of Science and Arts, Mohail Asser, King Khalid University, Saudi Arabia.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Jul 15; Vol. 198, pp. 112363. Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Benzodioxoles/*chemistry
ErbB Receptors/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemical synthesis
Thiourea/*chemical synthesis
Amines/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Hydrazines/chemistry ; Molecular Docking Simulation ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Structure-Activity Relationship ; Thiosemicarbazones/chemistry ; Thiourea/pharmacology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer.
Autorzy :
Sizemore G; Clinical and Translational Sciences Institute, West Virginia University, Morgantown, USA.
McLaughlin S; Animal Models & Imaging Facility, Cancer Institute, West Virginia University, Morgantown, USA.
Newman M; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV, 26506, USA.
Brundage K; Department of Microbiology and Cell Biology, Flow Cytometry Facility, West Virginia University, Morgantown, USA.
Ammer A; Animal Models & Imaging Facility, Cancer Institute, West Virginia University, Morgantown, USA.
Martin K; Animal Models & Imaging Facility, Cancer Institute, West Virginia University, Morgantown, USA.
Pugacheva E; Department of Biochemistry, Cancer Institute, West Virginia University, Morgantown, USA.
Coad J; Department of Pathology, West Virginia University, Morgantown, USA.
Mattes MD; Department of Radiation Oncology, Cancer Institute, West Virginia University, Morgantown, USA.
Yu HG; Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV, 26506, USA. .
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Źródło :
BMC cancer [BMC Cancer] 2020 Jun 26; Vol. 20 (1), pp. 595. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article
MeSH Terms :
Breast/*pathology
Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/*metabolism
Oxadiazoles/*pharmacology
Tetrazoles/*pharmacology
Thiourea/*analogs & derivatives
Triple Negative Breast Neoplasms/*drug therapy
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Line, Tumor ; Datasets as Topic ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Intravital Microscopy ; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/agonists ; Membrane Potentials/drug effects ; Mice ; Oxadiazoles/therapeutic use ; Patch-Clamp Techniques ; Tetrazoles/therapeutic use ; Thiourea/pharmacology ; Thiourea/therapeutic use ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase.
Autorzy :
Ullah S; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
El-Gamal MI; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt.
Zaib S; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Anbar HS; Department of Clinical Pharmacy and Pharmacotherapeutics, Dubai Pharmacy College for Girls, Dubai 19099, United Arab Emirates.
Zaraei SO; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.
Sbenati RM; Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates.
Pelletier J; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC G1V 4G2, Canada.
Sévigny J; Département de microbiologie-infectiologie et d'immunologie, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada; Centre de Recherche du CHU de Québec - Université Laval, Québec, QC G1V 4G2, Canada.
Oh CH; Center for Biomaterials, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea; Department of Biomolecular Science, Korea University of Science and Technology, 113 Gwahangno, Yuseong-gu, Daejeon 305-333, Republic of Korea. Electronic address: .
Iqbal J; Centre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Jun; Vol. 99, pp. 103783. Date of Electronic Publication: 2020 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Sulfonamides/*pharmacology
Thiourea/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Phosphoric Diester Hydrolases/metabolism ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Pyrophosphatases/antagonists & inhibitors ; Pyrophosphatases/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Thiourea/chemical synthesis ; Thiourea/chemistry
Czasopismo naukowe
Tytuł :
The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury.
Autorzy :
Shrum S; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Mail Slot 611, Little Rock, AR, 72205, USA.
Tobacyk J; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Mail Slot 611, Little Rock, AR, 72205, USA.
Lo S; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Mail Slot 611, Little Rock, AR, 72205, USA.
Parajuli N; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Mail Slot 611, Little Rock, AR, 72205, USA.
MacMillan-Crow LA; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Mail Slot 611, Little Rock, AR, 72205, USA. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Jul 30; Vol. 688, pp. 108410. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Kidney/*drug effects
Kidney Transplantation/*adverse effects
Large-Conductance Calcium-Activated Potassium Channels/*agonists
Mitochondria/*drug effects
Tetrazoles/*pharmacology
Thiourea/*analogs & derivatives
Animals ; Cell Death/drug effects ; Cryopreservation ; Kidney/metabolism ; Kidney/pathology ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Male ; Mitochondria/metabolism ; Rats ; Thiourea/pharmacology
Czasopismo naukowe
Tytuł :
Comparative study of alleviation effects of DMTU and PCIB on root growth inhibition in two tall fescue varieties under cadmium stress.
Autorzy :
Han M; College of Grassland Science, Beijing Forestry University, Beijing, 100083, China.
Wang B; College of Grassland Science, Beijing Forestry University, Beijing, 100083, China.
Song G; College of Grassland Science, Beijing Forestry University, Beijing, 100083, China. Electronic address: .
Shi S; State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of the State Forestry Administration, Research Institute of Forestry Research, Chinese Academy of Forestry, Box 1958, Beijing, 100091, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Jun 15; Vol. 196, pp. 110528. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Cadmium/*toxicity
Clofibric Acid/*pharmacology
Festuca/*drug effects
Oxidative Stress/*drug effects
Soil Pollutants/*toxicity
Thiourea/*analogs & derivatives
Abscisic Acid/metabolism ; Adaptation, Physiological/drug effects ; Festuca/growth & development ; Festuca/metabolism ; Hydrogen Peroxide/metabolism ; Indoleacetic Acids/metabolism ; Plant Roots/drug effects ; Plant Roots/growth & development ; Thiourea/pharmacology
Czasopismo naukowe
Tytuł :
Allergic contact dermatitis from diethylthiourea and carbamates in neoprene prayer socks with severe flare-up during patch testing.
Autorzy :
Özkaya E; Istanbul Faculty of Medicine, Department of Dermatology and Venereology, Istanbul University, Istanbul, Turkey.
Sun GP; Istanbul Faculty of Medicine, Department of Dermatology and Venereology, Istanbul University, Istanbul, Turkey.
Babuna Kobaner G; Istanbul Faculty of Medicine, Department of Dermatology and Venereology, Istanbul University, Istanbul, Turkey.
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Źródło :
Contact dermatitis [Contact Dermatitis] 2020 May; Vol. 82 (5), pp. 311-313. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Clothing*
Carbamates/*adverse effects
Dermatitis, Allergic Contact/*etiology
Foot Dermatoses/*chemically induced
Neoprene/*adverse effects
Thiourea/*analogs & derivatives
Dermatitis, Allergic Contact/drug therapy ; Dermatitis, Allergic Contact/pathology ; Foot Dermatoses/drug therapy ; Foot Dermatoses/pathology ; Glucocorticoids/therapeutic use ; Guanidines/adverse effects ; Humans ; Male ; Middle Aged ; Neoprene/chemistry ; Patch Tests ; Severity of Illness Index ; Symptom Flare Up ; Thiocarbamates/adverse effects ; Thiourea/adverse effects
Czasopismo naukowe
Tytuł :
In silico and in vitro antioxidant and anticancer activity profiles of urea and thiourea derivatives of 2,3-dihydro-1 H -inden-1-amine.
Autorzy :
Chandrasekhar M; Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Syam Prasad G; Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Venkataramaiah C; Departments of Zoology, Sri Venkateswara University, Tirupati, India.
Umapriya K; Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Raju CN; Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Seshaiah K; Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Rajendra W; Departments of Zoology, Sri Venkateswara University, Tirupati, India.
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Źródło :
Journal of receptor and signal transduction research [J Recept Signal Transduct Res] 2020 Feb; Vol. 40 (1), pp. 34-41. Date of Electronic Publication: 2020 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Amines/*pharmacology
Antineoplastic Agents/*pharmacology
Antioxidants/*pharmacology
Thiourea/*pharmacology
Urea/*pharmacology
Amines/chemical synthesis ; Amines/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Biphenyl Compounds/chemistry ; Free Radical Scavengers/chemistry ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Molecular Docking Simulation ; Nitric Oxide/chemistry ; Picrates/chemistry ; Thiourea/chemical synthesis ; Thiourea/chemistry ; Urea/chemical synthesis ; Urea/chemistry
Czasopismo naukowe

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