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Tytuł :
Multifunctional role of thymidine phosphorylase in cancer.
Autorzy :
Warfield BM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, V20-2102, Aurora, CO 80045, USA.
Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, V20-2102, Aurora, CO 80045, USA. Electronic address: .
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Źródło :
Trends in cancer [Trends Cancer] 2022 Jun; Vol. 8 (6), pp. 482-493. Date of Electronic Publication: 2022 Feb 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neoplasms*/drug therapy
Neoplasms*/metabolism
Thymidine Phosphorylase*/genetics
Thymidine Phosphorylase*/metabolism
Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Humans ; Neovascularization, Pathologic ; Thymidine
Czasopismo naukowe
Tytuł :
Mutational analyses of human thymidine kinase 2 reveal key residues in ATP-Mg binding and catalysis.
Autorzy :
Wang L; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Eriksson S; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
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Źródło :
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2022; Vol. 41 (3), pp. 264-272. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Mitochondrial Diseases*/genetics
Mitochondrial Diseases*/metabolism
Thymidine Kinase*/genetics
Thymidine Kinase*/metabolism
Adenosine Triphosphate/metabolism ; Catalysis ; Humans ; Thymidine/metabolism
Czasopismo naukowe
Tytuł :
Serum thymidine kinase 1 concentration as a predictive biomarker in prostate cancer.
Autorzy :
Lundgren PO; Department of Clinical Science, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Tribukait B; Department of Oncology-Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden.
Kjellman A; Department of Clinical Science, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
Norming U; Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden.
Jagarlmudi K; Department of Anatomy, Physiology, and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.; Research and Development Division, AroCell AB, Uppsala, Sweden.
Gustafsson O; Department of Clinical Science, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
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Źródło :
The Prostate [Prostate] 2022 Jun; Vol. 82 (8), pp. 911-916. Date of Electronic Publication: 2022 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Prostatic Neoplasms*
Thymidine Kinase*
Biomarkers ; Biomarkers, Tumor ; Case-Control Studies ; Humans ; Male
Czasopismo naukowe
Tytuł :
Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency.
Autorzy :
Lopez-Gomez C; H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY.; Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria/Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain.
Sanchez-Quintero MJ; H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY.; Area del Corazón. Hospital Clínico Universitario Virgen de la Victoria, CIBERCV. Instituto de Investigación Biomédica de Málaga-IBIMA. UMA, Málaga, Spain.
Lee EJ; H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY.
Kleiner G; H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY.
Tadesse S; H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY.
Xie J; Microbiology and Physiological Systems, University of Massachusetts Medical Center, Worcester, MA.; Horae Gene Therapy Center, University of Massachusetts Medical Center, Worcester, MA.
Akman HO; H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY.
Gao G; Microbiology and Physiological Systems, University of Massachusetts Medical Center, Worcester, MA.; Horae Gene Therapy Center, University of Massachusetts Medical Center, Worcester, MA.
Hirano M; H. Houston Merritt Neuromuscular Research Center, Department of Neurology, Columbia University Irving Medical Center, New York, NY.
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Źródło :
Annals of neurology [Ann Neurol] 2021 Oct; Vol. 90 (4), pp. 640-652. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Therapy*
Mitochondria/*metabolism
Mitochondrial Myopathies/*therapy
Thymidine Kinase/*deficiency
Animals ; Compassionate Use Trials ; DNA, Mitochondrial/genetics ; Humans ; Mice ; Mitochondria/genetics ; Mitochondrial Myopathies/genetics ; Mutation/genetics ; Thymidine/genetics ; Thymidine/metabolism ; Thymidine Kinase/genetics
Czasopismo naukowe
Tytuł :
Deoxynucleoside therapy for respiratory involvement in adult patients with thymidine kinase 2-deficient myopathy.
Autorzy :
Hernandez-Voth A; Servicio de Neumología, Unidad de Ventilación Mecánica, Hospital Universitario 12 de Octubre, Madrid, Spain .; Servicio de Neurologia, Unidad de Enfermedades Neuromusculares, Hospital Universitario 12 de Octubre, Madrid, Spain.
Sayas Catalan J; Servicio de Neumología, Unidad de Ventilación Mecánica, Hospital Universitario 12 de Octubre, Madrid, Spain.; Servicio de Neurologia, Unidad de Enfermedades Neuromusculares, Hospital Universitario 12 de Octubre, Madrid, Spain.; Instituto de Investigacion imas12, Hospital Universitario 12 de Octubre, Madrid, Spain.
Corral Blanco M; Servicio de Neumología, Unidad de Ventilación Mecánica, Hospital Universitario 12 de Octubre, Madrid, Spain.; Servicio de Neurologia, Unidad de Enfermedades Neuromusculares, Hospital Universitario 12 de Octubre, Madrid, Spain.
Castaño Mendez A; Servicio de Neumología, Unidad de Ventilación Mecánica, Hospital Universitario 12 de Octubre, Madrid, Spain.
Martin MA; Instituto de Investigacion imas12, Hospital Universitario 12 de Octubre, Madrid, Spain.; Departamento de Bioquímica, Laboratorio de Enfermedades Mitocondriales, Hospital Universitario 12 de Octubre, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain.
De Fuenmayor Fernandez de la Hoz C; Servicio de Neurologia, Unidad de Enfermedades Neuromusculares, Hospital Universitario 12 de Octubre, Madrid, Spain.
Villena Garrido V; Instituto de Investigacion imas12, Hospital Universitario 12 de Octubre, Madrid, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.; Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain.
Dominguez-Gonzalez C; Servicio de Neurologia, Unidad de Enfermedades Neuromusculares, Hospital Universitario 12 de Octubre, Madrid, Spain.; Instituto de Investigacion imas12, Hospital Universitario 12 de Octubre, Madrid, Spain.; Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.
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Źródło :
BMJ open respiratory research [BMJ Open Respir Res] 2020 Nov; Vol. 7 (1).
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Deoxycytidine*/therapeutic use
Mitochondrial Myopathies*/diagnosis
Mitochondrial Myopathies*/drug therapy
Mitochondrial Myopathies*/genetics
Respiratory Muscles*
Thymidine*/therapeutic use
Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Middle Aged ; Thymidine Kinase/genetics ; Vital Capacity ; Young Adult
Czasopismo naukowe
Tytuł :
The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum.
Autorzy :
Maltsev DI; Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Moscow, Russia, 117997.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, 117997.
Mellanson KA; Molecular and Cellular Pharmacology Graduate Program and Center for Developmental Genetics, Stony Brook University, Stony Brook, NY, 11794, USA.
Belousov VV; Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Moscow, Russia, 117997.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, 117997.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia, 117997.
Enikolopov GN; Center for Developmental Genetics and Department of Anesthesiology, Stony Brook University, Stony Brook, NY, 11794, USA.; Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, Russia, 119991.
Podgorny OV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, 117997. .; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia, 117997. .; Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia, 119334. .
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Źródło :
Histochemistry and cell biology [Histochem Cell Biol] 2022 Feb; Vol. 157 (2), pp. 239-250. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Bromodeoxyuridine/*metabolism
Deoxyuridine/*analogs & derivatives
Glyburide/*analogs & derivatives
Thymidine/*metabolism
Animals ; Biological Availability ; Bromodeoxyuridine/administration & dosage ; Bromodeoxyuridine/blood ; Dentate Gyrus/metabolism ; Deoxyuridine/administration & dosage ; Deoxyuridine/blood ; Deoxyuridine/metabolism ; Glyburide/administration & dosage ; Glyburide/blood ; Glyburide/metabolism ; Injections, Intraperitoneal ; Kinetics ; Mice ; Mice, Inbred C57BL ; Thymidine/administration & dosage ; Thymidine/analogs & derivatives
Czasopismo naukowe
Tytuł :
Pharmacodynamic Modeling of CDK4/6 Inhibition-Related Biomarkers and the Characterization of the Relationship Between Biomarker Response and Progression-Free Survival in Patients With Advanced Breast Cancer.
Autorzy :
Yu Y; Pfizer, Clinical Pharmacology, San Diego, California, USA.
Sun W; Vertex, Clinical Pharmacology, Boston, Massachusetts, USA.
Liu Y; Pfizer, Translational Oncology, San Diego, California, USA.
Wang D; Pfizer, Clinical Pharmacology, San Diego, California, USA.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2022 Mar; Vol. 62 (3), pp. 376-384. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Ki-67 Antigen/*blood
Piperazines/*pharmacology
Pyridines/*pharmacology
Retinoblastoma Protein/*blood
Thymidine Kinase/*blood
Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Breast Neoplasms/pathology ; China ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Female ; Humans ; Ki-67 Antigen/drug effects ; Metabolic Clearance Rate ; Models, Biological ; Neoplasm Staging ; Piperazines/pharmacokinetics ; Piperazines/therapeutic use ; Progression-Free Survival ; Pyridines/pharmacokinetics ; Pyridines/therapeutic use ; Retinoblastoma Protein/drug effects ; Thymidine Kinase/drug effects
Czasopismo naukowe
Tytuł :
Serum thymidine kinase activity in patients with hormone receptor-positive and HER2-negative metastatic breast cancer treated with palbociclib and fulvestrant.
Autorzy :
Malorni L; 'Sandro Pitigliani' Translational Research Unit and Medical Oncology Department, Hospital of Prato, Prato, Italy. Electronic address: .
Tyekucheva S; International Breast Cancer Study Group Statistical Center, Department of Data Science, Dana-Farber Cancer Institute and Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: .
Hilbers FS; Breast International Group, Brussels, Belgium; Department of Molecular Pathology, Netherlands Cancer Institute (NKI), Amsterdam, Netherlands. Electronic address: .
Ignatiadis M; Medical Oncology Department, Institut Jules Bordet and Université Libre de Bruxelles, Brussels, Belgium. Electronic address: .
Neven P; Department of Oncology, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Department of Gynecology and Obstetrics and Multidisciplinary Breast Center, UZ-KU Leuven Cancer Institute (LKI), Katholieke Universiteit, Leuven, Belgium. Electronic address: .
Colleoni M; International Breast Cancer Study Group and Division of Medical Senology, IEO, European Institute of Oncology, IRCCS, Milan, Italy. Electronic address: .
Henry S; Department of Medical Oncology, Hematology, Radiotherapy and Nuclear Medicine, Université Catholique de Louvain, CHU UCL Namur (Site Ste Elisabeth), Namur, Belgium. Electronic address: .
Ballestrero A; Department of Internal Medicine and Oncology, IRCCS Ospedale Policlinico San Martino, Genova, Italy. Electronic address: .
Bonetti A; Department of Oncology, AULSS 9 of the Veneto Region, Mater Salutis Hospital, Legnago, VR, Italy. Electronic address: .
Jerusalem G; International Breast Cancer Study Group and CHU Liège, Liège University, Liège, Belgium. Electronic address: .
Papadimitriou K; Multidisciplinary Oncologic Centre Antwerp (MOCA), Antwerp University Hospital, Antwerp, Belgium. Electronic address: .
Bernardo A; Medical Oncology Unit, ICS Maugeri-IRCCS, Pavia, Italy. Electronic address: .
Seles E; Ospedale Degli Infermi, Ponderano, Italy. Electronic address: .
Duhoux FP; Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, and Breast Clinic, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address: .
MacPherson IR; Wolfson Wohl Cancer Research Center, Institute of Cancer Sciences, University of Glasgow, UK. Electronic address: .
Thomson A; Royal Cornwall Hospital, Truro UK. Electronic address: .
Davies DM; Department of Oncology, South West Wales Oncology Center, Swansea, UK. Electronic address: .
Bergqvist M; Biovica, Uppsala, Sweden. Electronic address: .
Migliaccio I; 'Sandro Pitigliani' Translational Research Unit, Hospital of Prato, Prato, Italy. Electronic address: .
Gebhart G; Institut Jules Bordet-Université Libre de Bruxelles, Brussels, Belgium. Electronic address: .
Zoppoli G; Department of Internal Medicine, Università Degli Studi di Genova and IRCCS Ospedale Policlinico Martino, Genoa, Italy. Electronic address: .
Bliss JM; Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK. Electronic address: .
Benelli M; Bioinformatics Unit, Hospital of Prato, Prato, Italy. Electronic address: .
McCartney A; 'Sandro Pitigliani' Medical Oncology Department, Hospital of Prato, Prato, Italy; School of Clinical Sciences, Monash University, Melbourne, Australia. Electronic address: .
Kammler R; International Breast Cancer Study Group, Bern, Switzerland. Electronic address: .
De Swert H; Breast International Group, Brussels, Belgium. Electronic address: .
Ruepp B; International Breast Cancer Study Group, Bern, Switzerland. Electronic address: .
Fumagalli D; Breast International Group, Brussels, Belgium. Electronic address: .
Maibach R; International Breast Cancer Study Group, Bern, Switzerland. Electronic address: .
Cameron D; Breast International Group, Brussels, Belgium; Cancer Research UK Edinburgh Center, University of Edinburgh Cancer Research Center, Edinburgh, UK. Electronic address: .
Loi S; International Breast Cancer Study Group and Peter MacCallum Cancer Center, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: .
Piccart M; Institut Jules Bordet and L'Universite Libre de Bruxelles, Brussels, Belgium. Electronic address: .
Regan MM; International Breast Cancer Study Group Statistical Center, Division of Biostatistics, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. Electronic address: .
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Corporate Authors :
International Breast Cancer Study Group
Breast International Group and PYTHIA Collaborators
Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2022 Mar; Vol. 164, pp. 39-51. Date of Electronic Publication: 2022 Feb 13.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/pathology
Thymidine Kinase*/therapeutic use
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclin-Dependent Kinase 4 ; Female ; Fulvestrant/therapeutic use ; Humans ; Male ; Piperazines ; Prospective Studies ; Pyridines
Czasopismo naukowe
Tytuł :
Effect of Thymidine Phosphorylase Gene Demethylation on Sensitivity to 5-Fluorouracil in Colorectal Cancer Cells.
Autorzy :
Koyama M; Core Research Facilities, The Jikei University School of Medicine, Tokyo, Japan; .; Department of Gastrointestinal Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Osada E; Core Research Facilities, The Jikei University School of Medicine, Tokyo, Japan.
Akiyama N; Core Research Facilities, The Jikei University School of Medicine, Tokyo, Japan.
Eto K; Department of Gastrointestinal Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Manome Y; Core Research Facilities, The Jikei University School of Medicine, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2022 Feb; Vol. 42 (2), pp. 837-844.
Typ publikacji :
Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic/*pharmacology
Colorectal Neoplasms/*drug therapy
Fluorouracil/*pharmacology
Thymidine Phosphorylase/*metabolism
Antimetabolites, Antineoplastic/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; Colorectal Neoplasms/metabolism ; Decitabine/pharmacology ; Demethylation ; Drug Resistance, Neoplasm/drug effects ; Fluorouracil/therapeutic use ; Humans ; Thymidine Phosphorylase/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex.
Autorzy :
Spizzichino S; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Boi D; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Boumis G; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Lucchi R; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Liberati FR; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Capelli D; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Rome, Italy.
Montanari R; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Rome, Italy.
Pochetti G; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Rome, Italy.
Piacentini R; Center for Life Nano & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy.
Parisi G; Center for Life Nano & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy.
Paone A; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Rinaldo S; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Contestabile R; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Tramonti A; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.; Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.
Paiardini A; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Giardina G; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Cutruzzolà F; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.; Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
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Źródło :
The FEBS journal [FEBS J] 2022 Mar; Vol. 289 (6), pp. 1625-1649. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Thymidine Monophosphate*/metabolism
Thymidylate Synthase*/genetics
Thymidylate Synthase*/metabolism
Cell Nucleus/metabolism ; Glycine Hydroxymethyltransferase/genetics ; Glycine Hydroxymethyltransferase/metabolism ; Humans ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism
Czasopismo naukowe
Tytuł :
Recent advances in nucleotide analogue-based techniques for tracking dividing stem cells: An overview.
Autorzy :
Solius GM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Maltsev DI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Moscow, Russia.
Belousov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.
Podgorny OV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Nov; Vol. 297 (5), pp. 101345. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cell Cycle*
Cell Self Renewal*
Cell Tracking*
DNA Replication*
Stem Cells*/cytology
Stem Cells*/metabolism
Thymidine*/analogs & derivatives
Thymidine*/chemistry
Thymidine*/pharmacology
Animals ; Humans
Czasopismo naukowe
Tytuł :
Optimization of Thymidine Kinase-Based Safety Switch for Neural Cell Therapy.
Autorzy :
Locatelli M; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Delhaes F; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Cherpin O; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Black ME; School of Molecular Biosciences, Washington State University, Pullman, WA 99163, USA.
Carnesecchi S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Preynat-Seauve O; Laboratory of Therapy and Stem Cells, Geneva University Hospitals, CH-1211 Geneva, Switzerland.; Department of Medicine, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Hibaoui Y; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Krause KH; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.; Department of Genetic Medicine and Laboratory, Geneva Hospitals, CH-1211 Geneva, Switzerland.
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Źródło :
Cells [Cells] 2022 Jan 31; Vol. 11 (3). Date of Electronic Publication: 2022 Jan 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleosides*
Thymidine Kinase*/genetics
Thymidine Kinase*/metabolism
Cell- and Tissue-Based Therapy ; Ganciclovir/pharmacology ; Humans ; Neurons/metabolism
Czasopismo naukowe
Tytuł :
Polycondensed Peptide Carriers Modified with Cyclic RGD Ligand for Targeted Suicide Gene Delivery to Uterine Fibroid Cells.
Autorzy :
Egorova A; Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Shtykalova S; Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Maretina M; Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Selutin A; Department of Immunology and Intercellular Interactions, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Shved N; Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Deviatkin D; Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Selkov S; Department of Immunology and Intercellular Interactions, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Baranov V; Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
Kiselev A; Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, 199034 Saint Petersburg, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 21; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Transfer Techniques*
Genetic Therapy*
Leiomyoma/*therapy
Peptides, Cyclic/*chemistry
Simplexvirus/*genetics
Thymidine Kinase/*genetics
Uterine Neoplasms/*therapy
Female ; Humans ; Leiomyoma/genetics ; Leiomyoma/pathology ; Ligands ; Thymidine Kinase/administration & dosage ; Uterine Neoplasms/genetics ; Uterine Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Inactive-to-Active Transition of Human Thymidine Kinase 1 Revealed by Molecular Dynamics Simulations.
Autorzy :
Makurat S; Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Cournia Z; Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou, 11527 Athens, Greece.
Rak J; Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2022 Jan 10; Vol. 62 (1), pp. 142-149. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
Thymidine Kinase*/chemistry
Thymidine Kinase*/metabolism
Catalytic Domain ; Humans ; Protein Conformation
Czasopismo naukowe
Tytuł :
Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma.
Autorzy :
Wang L; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden. .
Unger L; Swiss Institute of Equine Medicine (ISME), Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, and Agroscope, Bern, Switzerland.
Sharif H; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.; Alertix Veterinary Diagnostic AB, SE-392 30, Kalmar, Sweden.
Eriksson S; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Gerber V; Swiss Institute of Equine Medicine (ISME), Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, and Agroscope, Bern, Switzerland.
Rönnberg H; Department of Clinical Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.
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Źródło :
BMC molecular and cell biology [BMC Mol Cell Biol] 2021 Dec 14; Vol. 22 (1), pp. 59. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Lymphoma*/diagnosis
Lymphoma*/veterinary
Thymidine Kinase*/genetics
Horse Diseases/*diagnosis
Animals ; Biomarkers, Tumor/genetics ; Horses
Czasopismo naukowe
Tytuł :
Novel Mutations of the TYMP Gene in Mitochondrial Neurogastrointestinal Encephalomyopathy: Case Series and Literature Review.
Autorzy :
Mojtabavi H; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.; Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fatehi F; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Shahkarami S; Department of Pediatrics, Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Dr. von, Munich, Germany.; Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Munich, Germany.
Rezaei N; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Nafissi S; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. .; Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. .
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Źródło :
Journal of molecular neuroscience : MN [J Mol Neurosci] 2021 Dec; Vol. 71 (12), pp. 2526-2533. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Phenotype*
Intestinal Pseudo-Obstruction/*genetics
Muscular Dystrophy, Oculopharyngeal/*genetics
Ophthalmoplegia/*congenital
Thymidine Phosphorylase/*genetics
Adolescent ; Codon, Nonsense ; Female ; Genes, Recessive ; Humans ; Intestinal Pseudo-Obstruction/pathology ; Iran ; Male ; Muscular Dystrophy, Oculopharyngeal/pathology ; Ophthalmoplegia/genetics ; Ophthalmoplegia/pathology ; Thymidine Phosphorylase/metabolism ; Young Adult
SCR Disease Name :
Visceral myopathy familial external ophthalmoplegia
Czasopismo naukowe
Tytuł :
Three new acrylic acid derivatives from Achillea mellifolium as potential thymidine phosphorylase inhibitor: molecular docking and MD simulation studies.
Autorzy :
Naz S; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Farooq U; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Ma H; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Sarwar R; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.
Riaz N; Department of Environmental Sciences, COMSATS University Islamabad, Abbottabad, Pakistan.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Nov; Vol. 39 (18), pp. 7138-7149. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Achillea*/chemistry
Thymidine Phosphorylase*/antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Acrylates ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Phytochemicals/pharmacology
Czasopismo naukowe
Tytuł :
Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker.
Autorzy :
Wang L; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden. .
Sharif H; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.; Alertix Veterinary Diagnostic AB, SE-392 30, Kalmar, Sweden.
Saellström S; University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Rönnberg H; Department of Clinical Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Eriksson S; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
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Źródło :
BMC veterinary research [BMC Vet Res] 2021 Sep 27; Vol. 17 (1), pp. 316. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers/*blood
Neoplasms/*veterinary
Thymidine Kinase/*blood
Animals ; Biomarkers/chemistry ; Cat Diseases/blood ; Cat Diseases/enzymology ; Cats ; Inflammation/blood ; Neoplasms/blood ; Neoplasms/diagnosis ; Sensitivity and Specificity ; Thymidine Kinase/chemistry ; Thymidine Kinase/genetics
Czasopismo naukowe
Tytuł :
Evaluation of Thymidine Phosphorylase Inhibitors in Glioblastoma and Their Capacity for Temozolomide Potentiation.
Autorzy :
Warfield BM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States.
Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States.
McArthur DG; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States.
Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States.
Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Sep 15; Vol. 12 (18), pp. 3477-3486. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glioblastoma*/drug therapy
Thymidine Phosphorylase*
Cell Line ; Humans ; Temozolomide/pharmacology ; Uracil
Czasopismo naukowe
Tytuł :
Neural differentiation of glioblastoma cell lines via a herpes simplex virus thymidine kinase/ganciclovir system driven by a glial fibrillary acidic protein promoter.
Autorzy :
Luo EW; Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Bioengineering, University of California, Los Angeles, California, United States of America.
Liao ML; Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.; School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Chien CL; Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
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Źródło :
PloS one [PLoS One] 2021 Aug 09; Vol. 16 (8), pp. e0253008. Date of Electronic Publication: 2021 Aug 09 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Thymidine Kinase*/antagonists & inhibitors
Thymidine Kinase*/biosynthesis
Thymidine Kinase*/genetics
Viral Proteins*/antagonists & inhibitors
Viral Proteins*/biosynthesis
Viral Proteins*/genetics
Cell Differentiation/*drug effects
Ganciclovir/*pharmacology
Glial Fibrillary Acidic Protein/*genetics
Glioblastoma/*metabolism
Neoplasm Proteins/*genetics
Simplexvirus/*genetics
Animals ; Cell Differentiation/genetics ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Glial Fibrillary Acidic Protein/metabolism ; Glioblastoma/genetics ; Glioblastoma/therapy ; Mice ; NIH 3T3 Cells ; Neoplasm Proteins/metabolism ; Simplexvirus/enzymology
Czasopismo naukowe

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