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Wyszukujesz frazę ""Thymidylate Synthase"" wg kryterium: Temat


Tytuł:
Sodium Butyrate Inhibits the Expression of Thymidylate Synthase and Induces Cell Death in Colorectal Cancer Cells.
Autorzy:
Kim N; Department of Science Education, Ewha Womans University, Seoul 03760, Republic of Korea.
Yang C; Department of Science Education, Ewha Womans University, Seoul 03760, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Thymidylate Synthase*/genetics
Thymidylate Synthase*/metabolism
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Humans ; Butyric Acid/pharmacology ; Drug Resistance, Neoplasm ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Apoptosis
Czasopismo naukowe
Tytuł:
Analysis of the TSER and G>C variants in the TYMS gene: a high frequency of low expression genotypes predicted in the Mexican population.
Autorzy:
Favela-Mendoza AF; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Godínez-López AD; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Chávez-Arreguin M; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Aguilar-Velázquez JA; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Martínez-Cortes G; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
Rangel-Villalobos H; Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Ocotlán, México.
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Źródło:
Annals of human biology [Ann Hum Biol] 2023 Feb; Vol. 50 (1), pp. 94-99.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorouracil*
Polymorphism, Genetic*
Thymidylate Synthase*/genetics
Thymidylate Synthase*/metabolism
Humans ; Alleles ; Genotype ; Polymorphism, Restriction Fragment Length ; Mexico
Czasopismo naukowe
Tytuł:
Development and validation a radiomics nomogram for predicting thymidylate synthase status in hepatocellular carcinoma based on Gd-DTPA contrast enhanced MRI.
Autorzy:
Ding Z; Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou, 350025, China.
Wu Y; Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou, 350025, China.
Fang G; Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou, 350025, China.
Lin Z; Department of Radiology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China.
Lin K; Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou, 350025, China.
Fu J; Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou, 350025, China.
Huang Q; Department of Radiotherapy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China.
Tang Y; Department of Radiology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China.
You W; Department of Radiology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China.
Liu J; Fujian Provincial Cancer Hospital, Fuzhou, 350025, China.
Zeng Y; Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou, 350025, China. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Oct 17; Vol. 23 (1), pp. 991. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/diagnostic imaging
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/diagnostic imaging
Liver Neoplasms*/pathology
Humans ; Gadolinium DTPA ; Nomograms ; Retrospective Studies ; Thymidylate Synthase ; Magnetic Resonance Imaging
Czasopismo naukowe
Tytuł:
Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay-Biological Implications.
Autorzy:
Naseem A; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., Sutton SM2 5NG, UK.
Pal A; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., Sutton SM2 5NG, UK.
Gowan S; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., Sutton SM2 5NG, UK.
Asad Y; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., Sutton SM2 5NG, UK.
Donovan A; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., Sutton SM2 5NG, UK.
Temesszentandrási-Ambrus C; SOLVO Biotechnology, Charles River Company, Irinyi József u. 4-20, 1117 Budapest, Hungary.
Kis E; SOLVO Biotechnology, Charles River Company, Irinyi József u. 4-20, 1117 Budapest, Hungary.
Gaborik Z; SOLVO Biotechnology, Charles River Company, Irinyi József u. 4-20, 1117 Budapest, Hungary.
Bhalay G; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., Sutton SM2 5NG, UK.
Raynaud F; Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Rd., Sutton SM2 5NG, UK.
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Źródło:
Cells [Cells] 2022 Oct 19; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multidrug Resistance-Associated Proteins*/metabolism
Thymidylate Synthase*/metabolism
Humans ; Caco-2 Cells ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Methylenetetrahydrofolate Reductase (NADPH2) ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Neoplasm Proteins/metabolism ; Multidrug Resistance-Associated Protein 2 ; Membrane Transport Proteins ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Permeability ; Folic Acid ; Methionine ; Carbon/metabolism
Czasopismo naukowe
Tytuł:
Single- and duplex TaqMan-quantitative PCR for determining the copy numbers of integrated selection markers during site-specific mutagenesis in Toxoplasma gondii by CRISPR-Cas9.
Autorzy:
Hänggeli KPA; Department of Infectious Diseases and Pathobiology, Institute of Parasitology, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Hemphill A; Department of Infectious Diseases and Pathobiology, Institute of Parasitology, University of Bern, Bern, Switzerland.
Müller N; Department of Infectious Diseases and Pathobiology, Institute of Parasitology, University of Bern, Bern, Switzerland.
Schimanski B; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
Olias P; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Müller J; Department of Infectious Diseases and Pathobiology, Institute of Parasitology, University of Bern, Bern, Switzerland.
Boubaker G; Department of Infectious Diseases and Pathobiology, Institute of Parasitology, University of Bern, Bern, Switzerland.
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Źródło:
PloS one [PLoS One] 2022 Sep 16; Vol. 17 (9), pp. e0271011. Date of Electronic Publication: 2022 Sep 16 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Thymidylate Synthase*/genetics
Thymidylate Synthase*/metabolism
Toxoplasma*
Antigens, Surface/pharmacology ; CRISPR-Cas Systems/genetics ; DNA/pharmacology ; DNA Copy Number Variations ; Mutagenesis, Site-Directed ; Polymerase Chain Reaction ; Pyrimethamine/pharmacology ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism
Czasopismo naukowe
Tytuł:
Machine-Learning- and Structure-Based Virtual Screening for Selecting Cinnamic Acid Derivatives as Leishmania major DHFR-TS Inhibitors.
Autorzy:
Muñoz-Vega MC; Department of Chemical Engineering, Universidad ECCI, Bogotá, Distrito Capital 111311, Colombia.; Laboratorio de Investigación en Biocatálisis y Biotransformaciones (LIBB), Grupo de Investigación en Ingeniería de los Procesos Agroalimentarios y Biotecnológicos (GIPAB), Departamento de Química Universidad del Valle, Cali 760042, Colombia.
López-Hernández S; Department of Chemical Engineering, Universidad ECCI, Bogotá, Distrito Capital 111311, Colombia.
Sierra-Chavarro A; Department of Chemical Engineering, Universidad ECCI, Bogotá, Distrito Capital 111311, Colombia.
Scotti MT; Post-Graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
Scotti L; Post-Graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
Coy-Barrera E; Bioorganic Chemistry Laboratory, Facultad de Ciencias Básicas y Aplicadas, Universidad Militar Nueva Granada, Cajicá 250247, Colombia.
Herrera-Acevedo C; Department of Chemical Engineering, Universidad ECCI, Bogotá, Distrito Capital 111311, Colombia.; Post-Graduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 28; Vol. 29 (1). Date of Electronic Publication: 2023 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Leishmania major*
Asteraceae*
Lignans*
Cinnamates*
Tetrahydrofolate Dehydrogenase ; Thymidylate Synthase ; Machine Learning
Czasopismo naukowe
Tytuł:
Association of Thymidylate Synthase ( TS ) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease.
Autorzy:
Kim JO; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.; Genetic Epidemiology Research Institute, Basgenbio Inc., Seoul 04167, Republic of Korea.
Ryu CS; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Lee JY; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Ko EJ; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Ha YH; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
Sung JH; Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea.
Hwang TS; Department of Anatomy, School of Medicine, CHA University, Seongnam 13488, Republic of Korea.
Kim IJ; Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea.
Kim NK; Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 09; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Coronary Artery Disease*/epidemiology
Coronary Artery Disease*/genetics
Humans ; Incidence ; Disease Susceptibility ; Thymidylate Synthase/genetics ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł:
Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression.
Autorzy:
Yang, Jian (AUTHOR)
Zhang, Jingjing (AUTHOR)
Chen, Jingtian (AUTHOR)
Yang, Xiaolong (AUTHOR)
Sun, Hui (AUTHOR)
Zhao, Zhenxiang (AUTHOR)
Zhou, Hui (AUTHOR)
Shen, Hao (AUTHOR)
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Źródło:
PLoS ONE. 9/8/2023, Vol. 18 Issue 9, p1-13. 13p.
Czasopismo naukowe
Tytuł:
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex.
Autorzy:
Spizzichino S; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Boi D; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Boumis G; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Lucchi R; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Liberati FR; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Capelli D; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Rome, Italy.
Montanari R; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Rome, Italy.
Pochetti G; Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Rome, Italy.
Piacentini R; Center for Life Nano & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy.
Parisi G; Center for Life Nano & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), Rome, Italy.
Paone A; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Rinaldo S; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Contestabile R; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Tramonti A; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.; Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.
Paiardini A; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Giardina G; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Cutruzzolà F; Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.; Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
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Źródło:
The FEBS journal [FEBS J] 2022 Mar; Vol. 289 (6), pp. 1625-1649. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Thymidine Monophosphate*/metabolism
Thymidylate Synthase*/genetics
Thymidylate Synthase*/metabolism
Cell Nucleus/metabolism ; Glycine Hydroxymethyltransferase/genetics ; Glycine Hydroxymethyltransferase/metabolism ; Humans ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism
Czasopismo naukowe
Tytuł:
Investigation of the Anticancer Effect of α -Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2( 1H )-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect.
Autorzy:
Nassan MA; Department of Clinical Laboratory Sciences, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Aldhahrani A; Department of Clinical Laboratory Sciences, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Amer HH; Department of Chemistry, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Elhenawy A; Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt.
Swelum AA; Department of Theriogenology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.; Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Ali OM; Department of Chemistry, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Zaki YH; Department of Chemistry, Faculty of Science, Beni-Suef University, Beni Suef 62514, Egypt.; Department of Chemistry, Faculty of Science and Humanity Studies at Al-Quwayiyah, Shaqra University, Al-Quwayiyah 11961, Saudi Arabia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 24; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Mammary Neoplasms, Experimental/*drug therapy
Thymidylate Synthase/*antagonists & inhibitors
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Antineoplastic Agents/pharmacology ; Caco-2 Cells ; Computer Simulation ; Drug Evaluation, Preclinical ; Female ; Fishes ; Humans ; Mammary Neoplasms, Experimental/chemically induced ; Mammary Neoplasms, Experimental/pathology ; Models, Molecular ; Molecular Docking Simulation ; Molecular Targeted Therapy/methods ; Organophosphonates/chemical synthesis ; Organophosphonates/chemistry ; Organophosphonates/pharmacology ; Organophosphonates/therapeutic use ; Plant Extracts ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Quinolines/pharmacology ; Quinolines/therapeutic use ; Rats ; Thymidylate Synthase/chemistry
Czasopismo naukowe
Tytuł:
Activity of pemetrexed in pre-clinical chordoma models and humans.
Autorzy:
Kesari S; Department of Translational Neurosciences, Pacific Neuroscience Institute, Santa Monica, CA, USA. .; Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA. .
Wang F; Department of Medical Oncology, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Sichuan, Chengdu, China. .
Juarez T; Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
Ashili S; CureScience, San Diego, CA, USA.
Patro CPK; CureScience, San Diego, CA, USA.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Carrillo J; Department of Translational Neurosciences, Pacific Neuroscience Institute, Santa Monica, CA, USA.; Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
Nguyen M; Department of Translational Neurosciences, Pacific Neuroscience Institute, Santa Monica, CA, USA.; Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
Truong J; Department of Translational Neurosciences, Pacific Neuroscience Institute, Santa Monica, CA, USA.; Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
Levy J; Chordoma Foundation, Durham, NC, USA.
Sommer J; Chordoma Foundation, Durham, NC, USA.
Freed DM; Chordoma Foundation, Durham, NC, USA.
Xiu J; CARIS Life Sciences, Phoenix, AZ, USA.
Takasumi Y; Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
Bouffet E; The Hospital for Sick Children (SickKids), University of Toronto, Toronto, Canada.
Gill JM; Department of Translational Neurosciences, Pacific Neuroscience Institute, Santa Monica, CA, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 May 05; Vol. 13 (1), pp. 7317. Date of Electronic Publication: 2023 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chordoma*/drug therapy
Humans ; Animals ; Mice ; Pemetrexed/pharmacology ; Pemetrexed/therapeutic use ; Prospective Studies ; Guanine/pharmacology ; Guanine/therapeutic use ; Glutamates/therapeutic use ; Glutamates/pharmacology ; Neoplasm Recurrence, Local/drug therapy ; DNA ; Thymidylate Synthase/genetics ; Thymidylate Synthase/metabolism
Czasopismo naukowe
Tytuł:
Molecular Mechanism of Thymidylate Synthase Inhibition by N -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.
Autorzy:
Maj P; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Jarmuła A; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Wilk P; Helmholtz-Zentrum Berlin, Macromolecular Crystallography (NP-GMX) Elektronenspeicherring BESSY II, 15 Albert-Einstein-St., D-12489 Berlin, Germany.
Prokopowicz M; College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences and Faculty of Physics, University of Warsaw, PL-02-097 Warszawa, Poland.
Rypniewski W; Institute of Bioorganic Chemistry, Polish Academy of Sciences, PL- 61-704 Poznań, Poland.
Zieliński Z; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Dowierciał A; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
Bzowska A; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, PL-02-093 Warszawa, Poland.
Rode W; Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji:
Journal Article
MeSH Terms:
Deoxycytidine Monophosphate/*analogs & derivatives
Enzyme Inhibitors/*pharmacology
Thymidylate Synthase/*antagonists & inhibitors
Trichinella/*enzymology
Animals ; Crystallography, X-Ray ; Deoxycytidine Monophosphate/chemistry ; Deoxycytidine Monophosphate/pharmacology ; Enzyme Inhibitors/chemistry ; Humans ; Mice ; Molecular Docking Simulation ; Spectrophotometry ; Thymidylate Synthase/chemistry ; Thymidylate Synthase/metabolism ; Trichinellosis/parasitology
Czasopismo naukowe
Tytuł:
Polymorphisms in TYMS for Prediction of Capecitabine-Induced Hand-Foot Syndrome in Chinese Patients with Colorectal Cancer.
Autorzy:
Dong SQ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wang TM; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhang JB; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
He YQ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xue WQ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wu ZY; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yang DW; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Cao LJ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Huang JW; School of Public Health, Sun Yat-sen University, Guangzhou, China.
Li XZ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhang PF; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zheng XH; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jia WH; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.; School of Public Health, Sun Yat-sen University, Guangzhou, China.; Cancer Center of Guangzhou Medical University, Guangzhou, China.
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Źródło:
Cancer research and treatment [Cancer Res Treat] 2021 Jul; Vol. 53 (3), pp. 724-732. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji:
Journal Article; Observational Study
MeSH Terms:
Antimetabolites, Antineoplastic/*adverse effects
Capecitabine/*adverse effects
Colorectal Neoplasms/*drug therapy
Hand-Foot Syndrome/*genetics
Thymidylate Synthase/*genetics
3' Untranslated Regions/genetics ; Adult ; Aged ; Aged, 80 and over ; Asian People/genetics ; Colorectal Neoplasms/genetics ; Female ; Genetic Predisposition to Disease ; Hand-Foot Syndrome/epidemiology ; Humans ; Hydro-Lyases/metabolism ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Thymidylate Synthase/metabolism
Czasopismo naukowe
Tytuł:
Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection.
Autorzy:
Bigot S; Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Quebec City, Québec, Canada.
Leprohon P; Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Quebec City, Québec, Canada.
Ouellette M; Centre de Recherche en Infectiologie du Centre de Recherche du CHU de Québec and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Quebec City, Québec, Canada.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Jun 29; Vol. 17 (6), pp. e0011458. Date of Electronic Publication: 2023 Jun 29 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leishmania major*/genetics
Folic Acid Antagonists*/pharmacology
Folic Acid Antagonists*/metabolism
Parasites*/metabolism
Animals ; Methotrexate/pharmacology ; Methotrexate/metabolism ; Drug Resistance/genetics ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism ; Folic Acid/metabolism ; Thymidylate Synthase/genetics
Czasopismo naukowe
Tytuł:
Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer Cells.
Autorzy:
Kurasaka C; Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Ogino Y; Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.; Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Sato A; Department of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antimetabolites, Antineoplastic/*pharmacology
Drug Resistance, Neoplasm/*genetics
Fluorouracil/*pharmacology
Thymidylate Synthase/*genetics
Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Floxuridine/pharmacology ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Irinotecan/pharmacology ; Platinum Compounds/pharmacology ; Thymidylate Synthase/metabolism ; Exome Sequencing
Czasopismo naukowe
Tytuł:
Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues.
Autorzy:
Prokopowicz M; Inter-Faculty Interdisciplinary Doctoral Studies in Natural Sciences and Mathematics, MISMaP College, University of Warsaw, ul. Banacha 2C, 02-097 Warsaw, Poland.; Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, 02-093 Warsaw, Poland.; Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland.
Jarmuła A; Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland.
Casamayou-Boucau Y; Nanoscale BioPhotonics Laboratory, School of Chemistry, National University of Ireland, University Road, H91 TK33 Galway, Ireland.
Gordon F; Nanoscale BioPhotonics Laboratory, School of Chemistry, National University of Ireland, University Road, H91 TK33 Galway, Ireland.
Ryder A; Nanoscale BioPhotonics Laboratory, School of Chemistry, National University of Ireland, University Road, H91 TK33 Galway, Ireland.
Sobich J; Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland.
Maj P; Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland.; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Cieśla J; Faculty of Chemistry, Warsaw University of Technology, ul Noakowskiego 3, 00-664 Warsaw, Poland.
Zieliński Z; Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland.
Fita P; Institute of Experimental Physics, Faculty of Physics, University of Warsaw, ul. Pasteura 5, 02-093 Warsaw, Poland.
Rode W; Nencki Institute of Experimental Biology, ul. Pasteura 3, 02-093 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 06; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Theoretical*
Static Electricity*
Deoxyuracil Nucleotides/*metabolism
Spectrometry, Fluorescence/*methods
Thymidylate Synthase/*metabolism
Amino Acid Substitution ; Animals ; Deoxycytidine Monophosphate/analogs & derivatives ; Deoxycytidine Monophosphate/metabolism ; Deoxyuracil Nucleotides/chemistry ; Fluorodeoxyuridylate/metabolism ; Mice ; Models, Molecular ; Multivariate Analysis ; Protein Conformation ; Thymidylate Synthase/chemistry
Czasopismo naukowe
Tytuł:
Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase-Low Squamous Cell Lung Cancer.
Autorzy:
Choi M; Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary's Hospital, Incheon, Korea.
Kim HT; Division of Hematology and Oncology, Department of Internal Medicine, National Cancer Center, Goyang, Korea.; Center for Lung Cancer, National Cancer Center, Goyang, Korea.
Han JY; Division of Hematology and Oncology, Department of Internal Medicine, National Cancer Center, Goyang, Korea.; Center for Lung Cancer, National Cancer Center, Goyang, Korea.
Lee GK; Department of Pathology, National Cancer Center, Goyang, Korea.
Lee SH; Department of Radiology, National Cancer Center, Goyang, Korea.
Lim KY; Department of Radiology, National Cancer Center, Goyang, Korea.
Joo J; Office of Biostatistics Research, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, USA.
Won HJ; Center for Lung Cancer, National Cancer Center, Goyang, Korea.
Lee JS; Center for Lung Cancer, National Cancer Center, Goyang, Korea.
Lee Y; Division of Hematology and Oncology, Department of Internal Medicine, National Cancer Center, Goyang, Korea.; Center for Lung Cancer, National Cancer Center, Goyang, Korea.
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Źródło:
Cancer research and treatment [Cancer Res Treat] 2021 Jan; Vol. 53 (1), pp. 87-92. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji:
Clinical Trial, Phase II; Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*drug therapy
Carcinoma, Squamous Cell/*drug therapy
Lung Neoplasms/*drug therapy
Pemetrexed/*therapeutic use
Salvage Therapy/*methods
Thymidylate Synthase/*therapeutic use
Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Pemetrexed/pharmacology ; Thymidylate Synthase/pharmacology
Czasopismo naukowe
Tytuł:
Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.
Autorzy:
Bhattacharya A; Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec, Centre de recherche en Infectiologie, and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec City, Canada.
Leprohon P; Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec, Centre de recherche en Infectiologie, and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec City, Canada.
Ouellette M; Axe des Maladies Infectieuses et Immunitaires du Centre de Recherche du CHU de Québec, Centre de recherche en Infectiologie, and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec City, Canada.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Apr 27; Vol. 15 (4), pp. e0009377. Date of Electronic Publication: 2021 Apr 27 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Deletion*
Leishmania infantum/*drug effects
Leishmania infantum/*genetics
Methotrexate/*pharmacology
Multienzyme Complexes/*genetics
Tetrahydrofolate Dehydrogenase/*genetics
Thymidylate Synthase/*genetics
Animals ; DNA, Protozoan/genetics ; DNA, Recombinant/genetics ; Drug Resistance ; Folic Acid/metabolism ; Folic Acid Antagonists/metabolism ; Folic Acid Antagonists/pharmacology ; Leishmania infantum/enzymology ; Methotrexate/metabolism ; Multienzyme Complexes/metabolism ; Phenotype ; Tetrahydrofolate Dehydrogenase/metabolism ; Thymidylate Synthase/metabolism ; Transfection
Czasopismo naukowe

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