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Tytuł :
Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
Autorzy :
Bautista JL; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Cramer NT; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Miller CN; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Chavez J; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Berrios DI; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Byrnes LE; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Germino J; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Bakar Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Ntranos V; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Bakar Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Sneddon JB; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.; Department of Cell and Tissue Biology, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA.
Burt TD; Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.; Division of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Division of Neonatology and the Children's Health & Discovery Initiative, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
Gardner JM; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Ye CJ; Bakar Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Anderson MS; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Parent AV; Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 17; Vol. 12 (1), pp. 1096. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Epithelial Cells/*metabolism
Gene Expression Profiling/*methods
Single-Cell Analysis/*methods
Thymus Gland/*metabolism
Adult ; Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Humans ; Mesoderm/cytology ; Mesoderm/metabolism ; Mice ; Pericytes/cytology ; Pericytes/metabolism ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism ; Thymocytes/cytology ; Thymocytes/metabolism ; Thymus Gland/cytology ; Thymus Gland/embryology
Czasopismo naukowe
Tytuł :
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.
Autorzy :
Ferreira ACF; MRC Laboratory of Molecular Biology, Cambridge, UK. .
Szeto ACH; MRC Laboratory of Molecular Biology, Cambridge, UK.
Heycock MWD; MRC Laboratory of Molecular Biology, Cambridge, UK.
Clark PA; MRC Laboratory of Molecular Biology, Cambridge, UK.
Walker JA; MRC Laboratory of Molecular Biology, Cambridge, UK.; AstraZeneca, Aaron Klug Building, Cambridge, UK.
Crisp A; MRC Laboratory of Molecular Biology, Cambridge, UK.
Barlow JL; MRC Laboratory of Molecular Biology, Cambridge, UK.; Department of Biology, University of York, York, UK.
Kitching S; MRC Laboratory of Molecular Biology, Cambridge, UK.
Lim A; MRC Laboratory of Molecular Biology, Cambridge, UK.; Theolytics Ltd, Oxford, UK.
Gogoi M; MRC Laboratory of Molecular Biology, Cambridge, UK.
Berks R; MRC Laboratory of Molecular Biology, Cambridge, UK.
Daly M; MRC Laboratory of Molecular Biology, Cambridge, UK.
Jolin HE; MRC Laboratory of Molecular Biology, Cambridge, UK.
McKenzie ANJ; MRC Laboratory of Molecular Biology, Cambridge, UK. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Feb; Vol. 22 (2), pp. 166-178. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Cell Lineage*
Immunity, Innate*
CD4-Positive T-Lymphocytes/*metabolism
CD8-Positive T-Lymphocytes/*metabolism
Nuclear Receptor Subfamily 1, Group F, Member 1/*metabolism
Thymocytes/*metabolism
Thymus Gland/*metabolism
Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Movement ; Cells, Cultured ; Coculture Techniques ; Female ; Gene Expression Regulation, Developmental ; Inhibitor of Differentiation Protein 2/genetics ; Inhibitor of Differentiation Protein 2/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nuclear Receptor Subfamily 1, Group F, Member 1/genetics ; Organ Culture Techniques ; Phenotype ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Signal Transduction ; Thymocytes/immunology ; Thymus Gland/embryology ; Thymus Gland/immunology ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure.
Autorzy :
Murray MP; La Jolla Institute for Immunology, La Jolla, CA, USA.
Engel I; La Jolla Institute for Immunology, La Jolla, CA, USA.
Seumois G; La Jolla Institute for Immunology, La Jolla, CA, USA.
Herrera-De la Mata S; La Jolla Institute for Immunology, La Jolla, CA, USA.
Rosales SL; La Jolla Institute for Immunology, La Jolla, CA, USA.
Sethi A; La Jolla Institute for Immunology, La Jolla, CA, USA.
Logandha Ramamoorthy Premlal A; La Jolla Institute for Immunology, La Jolla, CA, USA.
Seo GY; La Jolla Institute for Immunology, La Jolla, CA, USA.
Greenbaum J; La Jolla Institute for Immunology, La Jolla, CA, USA.
Vijayanand P; La Jolla Institute for Immunology, La Jolla, CA, USA.; University of Southampton, Faculty of Medicine, Southampton, UK.; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Scott-Browne JP; La Jolla Institute for Immunology, La Jolla, CA, USA. .; Department of Biomedical Research, National Jewish Health, Denver, CO, USA. .
Kronenberg M; La Jolla Institute for Immunology, La Jolla, CA, USA. .; Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 04; Vol. 12 (1), pp. 1446. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Lung/*cytology
Natural Killer T-Cells/*cytology
T Follicular Helper Cells/*cytology
T-Lymphocyte Subsets/*cytology
Thymus Gland/*cytology
Animals ; Cell Differentiation/immunology ; Chromatin/genetics ; Female ; Lung/immunology ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Natural Killer T-Cells/immunology ; T Follicular Helper Cells/immunology ; T-Lymphocyte Subsets/immunology ; Thymus Gland/immunology ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments.
Autorzy :
Lopes N; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
McIntyre C; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Martin S; Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
Raverdeau M; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Sumaria N; Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK.
Kohlgruber AC; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Fiala GJ; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Agudelo LZ; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.
Dyck L; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Kane H; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Douglas A; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Cunningham S; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Prendeville H; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Loftus R; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
Carmody C; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pierre P; Aix Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.; Institute for Research in Biomedicine (iBiMED) and Ilidio Pinho Foundation, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Kellis M; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.
Brenner M; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Argüello RJ; Aix Marseille Université, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Silva-Santos B; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Pennington DJ; Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK. .
Lynch L; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
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Źródło :
Nature immunology [Nat Immunol] 2021 Feb; Vol. 22 (2), pp. 179-192. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism*
Tumor Microenvironment*
Breast Neoplasms/*metabolism
Colonic Neoplasms/*metabolism
Lymphocytes, Tumor-Infiltrating/*metabolism
Melanoma, Experimental/*metabolism
Receptors, Antigen, T-Cell, gamma-delta/*metabolism
T-Lymphocyte Subsets/*metabolism
Thymus Gland/*metabolism
Animals ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cell Line, Tumor ; Cell Lineage ; Colonic Neoplasms/immunology ; Colonic Neoplasms/pathology ; Colonic Neoplasms/therapy ; Female ; Glucose/metabolism ; Glycolysis ; Humans ; Immunotherapy, Adoptive ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Lipid Metabolism ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/transplantation ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Melanoma, Experimental/therapy ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitochondria/metabolism ; Obesity/immunology ; Obesity/metabolism ; Organ Culture Techniques ; Phenotype ; Signal Transduction ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/transplantation ; Thymus Gland/immunology ; Tumor Burden
Czasopismo naukowe
Tytuł :
MAIT cell development in mice and humans.
Autorzy :
Salou M; INSERM U932, PSL University, Institut Curie, Paris, 75005, France.
Legoux F; INSERM U932, PSL University, Institut Curie, Paris, 75005, France.
Lantz O; INSERM U932, PSL University, Institut Curie, Paris, 75005, France; Laboratoire d'immunologie clinique, Institut Curie, Paris, 75005, France; Centre d'investigation Clinique en Biothérapie, Institut Curie (CIC-BT1428), Paris, 75005, France. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 31-36. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cell Differentiation*/genetics
Cell Differentiation*/immunology
Mucosal-Associated Invariant T Cells/*physiology
Thymus Gland/*cytology
Animals ; Gene Rearrangement, T-Lymphocyte/genetics ; Gene Rearrangement, T-Lymphocyte/physiology ; Humans ; Mice ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Species Specificity ; Thymocytes/immunology ; Thymocytes/metabolism ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
The effect of ammonia exposure on energy metabolism and mitochondrial dynamic proteins in chicken thymus: Through oxidative stress, apoptosis, and autophagy.
Autorzy :
Shah SWA; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Electronic address: .
Chen D; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China; College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China. Electronic address: .
Zhang J; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Electronic address: .
Liu Y; Heilongjiang Animal Husbandry Station, Harbin 150069, China. Electronic address: .
Ishfaq M; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, 600 Chang jiang Road, Xiang Fang District, Harbin 150030, China. Electronic address: .
Tang Y; Electrical and Information Engineering College, Jilin Agricultural Science and Technology University, Jilin 132101, China. Electronic address: .
Teng X; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 15; Vol. 206, pp. 111413. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Air Pollutants/*toxicity
Ammonia/*toxicity
Apoptosis/*drug effects
Chickens/*metabolism
Energy Metabolism/*drug effects
Mitochondrial Proteins/*metabolism
Oxidative Stress/*drug effects
Thymus Gland/*drug effects
Animals ; Antioxidants/metabolism ; Autophagy/drug effects ; In Situ Nick-End Labeling ; Mitochondrial Dynamics/drug effects ; Mitochondrial Proteins/genetics ; Thymus Gland/immunology ; Thymus Gland/metabolism ; Thymus Gland/pathology
Czasopismo naukowe
Tytuł :
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds.
Autorzy :
Campinoti S; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Gjinovci A; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Royal Free Hospital, London, NW3 2PF, UK.
Ragazzini R; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Royal Free Hospital, London, NW3 2PF, UK.
Zanieri L; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Royal Free Hospital, London, NW3 2PF, UK.
Ariza-McNaughton L; Haematopoietic Stem Cell laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Catucci M; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.; Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, DIBIT 20132, Milan, Italy.
Boeing S; Bioinformatics Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Park JE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Hutchinson JC; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 1EH, UK.
Muñoz-Ruiz M; Immunosurveillance laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Manti PG; Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Vozza G; Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Villa CE; Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
Phylactopoulos DE; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Maurer C; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Testa G; Department of Experimental Oncology, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Stauss HJ; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Royal Free Hospital, London, NW3 2PF, UK.
Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Sebire NJ; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 1EH, UK.
Hayday AC; Immunosurveillance laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK.
Bonnet D; Haematopoietic Stem Cell laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Bonfanti P; Epithelial Stem Cell Biology & Regenerative Medicine laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. .; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. .; Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, Royal Free Hospital, London, NW3 2PF, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 11; Vol. 11 (1), pp. 6372. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stromal Cells*
Thymus Gland/*immunology
Animals ; Autoimmunity ; Cell Differentiation ; Epithelial Cells/immunology ; Extracellular Matrix ; Female ; Humans ; Male ; Mice ; Mice, Nude ; Rats ; Regeneration ; Thymocytes ; Thymus Gland/pathology ; Thymus Gland/transplantation ; Tissue Scaffolds
Czasopismo naukowe
Tytuł :
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Autorzy :
Watanabe M; Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA.
Lu Y; Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA.
Breen M; Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA.
Hodes RJ; Experimental Immunology Branch, National Cancer Institute, Bethesda, MD, 20892, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 08; Vol. 11 (1), pp. 6264. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Central Tolerance*
Clonal Deletion*
B7-1 Antigen/*metabolism
CD28 Antigens/*metabolism
T-Lymphocytes, Regulatory/*immunology
Thymus Gland/*immunology
Animals ; Antigen-Presenting Cells/metabolism ; Autoimmunity/physiology ; CD28 Antigens/genetics ; Cell Differentiation/immunology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Flow Cytometry ; Gene Knock-In Techniques ; Mice ; Mice, Knockout ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Signal Transduction/immunology ; T-Lymphocytes, Regulatory/metabolism ; Thymocytes/physiology ; Thymus Gland/cytology ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.
Autorzy :
Harsha Krovi S; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Evergrande Center for Immunologic diseases at Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Zhang J; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Stanford Health Care, Department of Pathology, Stanford University, Stanford, CA, USA.
Michaels-Foster MJ; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Brunetti T; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Loh L; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Scott-Browne J; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.
Gapin L; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. .; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 07; Vol. 11 (1), pp. 6238. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Differentiation/*immunology
Immunity, Innate/*immunology
Natural Killer T-Cells/*immunology
Single-Cell Analysis/*methods
T-Lymphocytes/*immunology
Thymus Gland/*immunology
Animals ; Cell Differentiation/genetics ; Cells, Cultured ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/immunology ; DNA-Binding Proteins/metabolism ; Gene Expression Profiling/methods ; Immunity, Innate/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Mucosal-Associated Invariant T Cells/cytology ; Mucosal-Associated Invariant T Cells/immunology ; Mucosal-Associated Invariant T Cells/metabolism ; Natural Killer T-Cells/cytology ; Natural Killer T-Cells/metabolism ; Sequence Analysis, RNA/methods ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism ; Thymocytes/cytology ; Thymocytes/immunology ; Thymocytes/metabolism ; Thymus Gland/cytology ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression.
Autorzy :
Ito-Kureha T; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Miyao T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Nishijima S; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Suzuki T; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Koizumi SI; Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Villar-Briones A; Instrumental Analysis Section, Research Support Division, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Takahashi A; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Akiyama N; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Morita M; Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Naguro I; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Ishikawa H; Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Ichijo H; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Akiyama T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .
Yamamoto T; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan. .; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 02; Vol. 11 (1), pp. 6169. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Exoribonucleases/*genetics
Repressor Proteins/*genetics
Thymocytes/*immunology
Thymus Gland/*immunology
Animals ; Apoptosis/immunology ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/immunology ; Cell Differentiation ; Cell Lineage/genetics ; Cell Lineage/immunology ; Exoribonucleases/immunology ; Gene Expression Regulation, Developmental ; Mice ; Poly A/genetics ; Poly A/immunology ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; Repressor Proteins/immunology ; Signal Transduction ; Thymocytes/cytology ; Thymus Gland/cytology ; Thymus Gland/growth & development ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/immunology ; ras GTPase-Activating Proteins/genetics ; ras GTPase-Activating Proteins/immunology
Czasopismo naukowe
Tytuł :
Thymus development in the zebrafish (Danio rerio) from an ecoimmunology perspective.
Autorzy :
Kernen L; Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland.
Rieder J; Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland.
Duus A; Department of Biology, University of Southern Denmark, Odense, Denmark.
Holbech H; Department of Biology, University of Southern Denmark, Odense, Denmark.
Segner H; Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland.
Bailey C; Fish Immunology and Pathology Group, Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain.
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Źródło :
Journal of experimental zoology. Part A, Ecological and integrative physiology [J Exp Zool A Ecol Integr Physiol] 2020 Dec; Vol. 333 (10), pp. 805-819. Date of Electronic Publication: 2020 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Thymus Gland/*growth & development
Zebrafish/*immunology
Animals ; Cell Count ; Ecology ; Female ; Male ; Organ Size ; Thymocytes/immunology ; Thymus Gland/anatomy & histology ; Thymus Gland/immunology ; Vitellogenins/metabolism ; Zebrafish/anatomy & histology ; Zebrafish/growth & development
Czasopismo naukowe
Tytuł :
Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis.
Autorzy :
Jiang R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511.
Hoehn KB; Department of Pathology, Yale University School of Medicine, New Haven, CT 06511.
Lee CS; Department of Neurology, Yale University School of Medicine, New Haven, CT 06511.
Pham MC; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511.
Homer RJ; Department of Pathology, Yale University School of Medicine, New Haven, CT 06511.; Pathology & Laboratory Medicine Service, VA CT Health Care System, West Haven, CT 06516.
Detterbeck FC; Department of Surgery, Yale University School of Medicine, New Haven, CT 06511.
Aban I; Department of Biostatistics, University of Alabama, Birmingham, AL 35294.
Jacobson L; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX1 2JD Oxford, United Kingdom.
Vincent A; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX1 2JD Oxford, United Kingdom.
Nowak RJ; Department of Neurology, Yale University School of Medicine, New Haven, CT 06511.
Kaminski HJ; Department of Neurology, The George Washington University, Washington, DC 20052.
Kleinstein SH; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511; .; Department of Pathology, Yale University School of Medicine, New Haven, CT 06511.; Interdepartmental Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06511.
O'Connor KC; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511; .; Department of Neurology, Yale University School of Medicine, New Haven, CT 06511.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 01; Vol. 117 (48), pp. 30649-30660. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocyte Count*
B-Lymphocytes/*metabolism
Myasthenia Gravis/*blood
Thymus Gland/*metabolism
Adolescent ; Adult ; Autoantibodies/immunology ; B-Lymphocytes/immunology ; Biomarkers ; Clonal Evolution/genetics ; Clonal Selection, Antigen-Mediated ; Disease Susceptibility ; Female ; Humans ; Male ; Middle Aged ; Models, Biological ; Myasthenia Gravis/etiology ; Radioimmunoassay ; Receptors, Cholinergic/immunology ; Thymectomy ; Thymus Gland/cytology ; Thymus Gland/immunology ; V(D)J Recombination ; Young Adult
Czasopismo naukowe
Tytuł :
Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair.
Autorzy :
Elyahu Y; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Zlotowski Neuroscience Center and Regenerative Medicine and Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel; National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Monsonego A; The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Zlotowski Neuroscience Center and Regenerative Medicine and Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel; National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: .
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Źródło :
Ageing research reviews [Ageing Res Rev] 2021 Jan; Vol. 65, pp. 101231. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
T-Lymphocytes*
Thymus Gland*
Czasopismo naukowe
Tytuł :
Potential impact of SARS-CoV-2 infection on the thymus.
Autorzy :
Lins MP; Laboratory of Cell Biology, Institute of Biological and Health Sciences, Federal University of Alagoas - Maceió/AL, Brazil.; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil.
Smaniotto S; Laboratory of Cell Biology, Institute of Biological and Health Sciences, Federal University of Alagoas - Maceió/AL, Brazil.; Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil.
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Źródło :
Canadian journal of microbiology [Can J Microbiol] 2021 Jan; Vol. 67 (1), pp. 23-28. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*complications
COVID-19/*immunology
Lymphopenia/*complications
Thymus Gland/*virology
Animals ; Humans ; Lymphopenia/immunology ; Lymphopenia/virology ; Mice ; Models, Immunological ; Pandemics ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
ALK-transformed mature T lymphocytes restore early thymus progenitor features.
Autorzy :
Congras A; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.
Hoareau-Aveilla C; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.
Caillet N; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.
Tosolini M; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Pôle Technologique du CRCT, Plateau Bioinformatique, Toulouse, France.
Villarese P; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Cieslak A; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Rodriguez L; Etablissement Français du Sang, Nouvelle Aquitaine, INSERM U1035, Université de Bordeaux, Bordeaux, France.
Asnafi V; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Macintyre E; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.
Egger G; Department of Pathology, Medical University Vienna, Vienna, Austria.; Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria.
Brousset P; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.; Institut Carnot Lymphome, Toulouse, France.; Laboratoire d'Excellence Toulouse Cancer and after Cancer (Labex TOUCAN), Toulouse, France.
Lamant L; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.; Institut Carnot Lymphome, Toulouse, France.; Laboratoire d'Excellence Toulouse Cancer and after Cancer (Labex TOUCAN), Toulouse, France.; European Research Initiative on ALK-Related Malignancies, Cambridge, United Kingdom, Vienna, Austria, and Toulouse, France.
Meggetto F; INSERM, UMR1037 CRCT, F-31000, Toulouse, France.; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France.; CNRS, ERL5294 UMR1037 CRCT, F-31000, Toulouse, France.; Equipe Labellisée LIGUE 2017, Toulouse, France.; Hematology and INSERM1151, Institut Necker-Enfants Malades, University Sorbonne Paris Cité at Descartes and Assistance Publique-Hopitaux de Paris, Paris, France.; Institut Carnot Lymphome, Toulouse, France.; Laboratoire d'Excellence Toulouse Cancer and after Cancer (Labex TOUCAN), Toulouse, France.; European Research Initiative on ALK-Related Malignancies, Cambridge, United Kingdom, Vienna, Austria, and Toulouse, France.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Dec 01; Vol. 130 (12), pp. 6395-6408.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anaplastic Lymphoma Kinase/*biosynthesis
CD4-Positive T-Lymphocytes/*enzymology
Cell Transformation, Neoplastic/*metabolism
Lymphoma, Large-Cell, Anaplastic/*enzymology
Neoplastic Stem Cells/*enzymology
Thymus Gland/*enzymology
Anaplastic Lymphoma Kinase/genetics ; Animals ; CD4-Positive T-Lymphocytes/pathology ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Female ; Humans ; Lymphoma, Large-Cell, Anaplastic/genetics ; Lymphoma, Large-Cell, Anaplastic/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplastic Stem Cells/pathology ; Thymus Gland/pathology
Czasopismo naukowe
Tytuł :
Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing.
Autorzy :
Rezzani R; Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.; Interdipartimental University Center of Research 'Adaption and Regeneration of Tissues and Organs-(ARTO)', University of Brescia, 25123 Brescia, Italy.
Franco C; Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Hardeland R; Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Göttingen, Lower Saxony, D-37073 Göttingen, Germany.
Rodella LF; Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.; Interdipartimental University Center of Research 'Adaption and Regeneration of Tissues and Organs-(ARTO)', University of Brescia, 25123 Brescia, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 20; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aging*
Melatonin/*metabolism
Pineal Gland/*physiology
Thymus Gland/*physiology
Animals ; Circadian Rhythm ; Humans ; Peptides/metabolism ; Pineal Gland/ultrastructure ; Thymus Gland/ultrastructure
Czasopismo naukowe
Tytuł :
Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.
Autorzy :
Martinikova AS; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, CZ14220 Prague, Czech Republic.; Department of Developmental and Cell Biology, Faculty of Science, Charles University, Albertov 6, CZ12800 Prague, Czech Republic.
Burocziova M; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, CZ14220 Prague, Czech Republic.
Stoyanov M; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, CZ14220 Prague, Czech Republic.
Macurek L; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, CZ14220 Prague, Czech Republic.
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Źródło :
Cells [Cells] 2020 Sep 10; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Thymus Gland*/cytology
Thymus Gland*/metabolism
Lymphoma/*metabolism
Protein Phosphatase 2C/*physiology
Thymocytes/*cytology
Tumor Suppressor Protein p53/*metabolism
Animals ; Cell Cycle ; Cell Proliferation ; DNA Damage ; DNA Repair ; Mice ; Mice, Inbred C57BL ; Neoplasms, Radiation-Induced/metabolism ; Radiation, Ionizing ; Thymocytes/metabolism
Czasopismo naukowe
Tytuł :
β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance.
Autorzy :
McIntyre CL; Institute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.
Monin L; Immunosurveillance Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom.
Rop JC; Institute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.
Otto TD; Institute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.
Goodyear CS; Institute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.
Hayday AC; Immunosurveillance Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom.; Peter Gorer Department of Immunobiology, King's College London, WC2R 2LS London, United Kingdom.
Morrison VL; Institute of Infection, Immunity & Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 08; Vol. 117 (36), pp. 22367-22377. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD18 Antigens*/genetics
CD18 Antigens*/immunology
CD18 Antigens*/metabolism
Intraepithelial Lymphocytes*/immunology
Intraepithelial Lymphocytes*/metabolism
Intraepithelial Lymphocytes*/physiology
Thymus Gland*/growth & development
Thymus Gland*/immunology
Thymus Gland*/metabolism
Animals ; Homeostasis/immunology ; Interleukin-17/genetics ; Interleukin-17/immunology ; Interleukin-17/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Spleen and thymus metabolomics strategy to explore the immunoregulatory mechanism of total withanolides from the leaves of Datura metel L. on imiquimod-induced psoriatic skin dermatitis in mice.
Autorzy :
Cheng Y; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
Liu Y; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
Tan J; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
Sun Y; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
Guan W; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
Liu Y; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
Yang B; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
Kuang H; Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2020 Sep; Vol. 34 (9), pp. e4881. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolome*/drug effects
Metabolome*/immunology
Psoriasis*/chemically induced
Psoriasis*/metabolism
Spleen*/drug effects
Spleen*/metabolism
Thymus Gland*/drug effects
Thymus Gland*/metabolism
Datura metel/*chemistry
Withanolides/*pharmacology
Animals ; Disease Models, Animal ; Imiquimod/adverse effects ; Immunosuppressive Agents/pharmacology ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Plant Extracts/chemistry ; Plant Leaves/chemistry
Czasopismo naukowe
Tytuł :
Flavonoids from Rosa Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation roxburghii Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation in vivo .
Autorzy :
Xu SJ; Department of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Wang X; College of Medical Laboratory, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Wang TY; Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Lin ZZ; Department of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Hu YJ; Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Huang ZL; Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Yang XJ; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang 453003, Henan, China.
Xu P; Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang 453003, Henan, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Aug 29; Vol. 12 (16), pp. 16368-16389. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Rosa*/chemistry
Antioxidants/*pharmacology
DNA Breaks, Double-Stranded/*drug effects
Flavonoids/*pharmacology
Oxidative Stress/*drug effects
Poly (ADP-Ribose) Polymerase-1/*metabolism
Reactive Oxygen Species/*metabolism
Thymus Gland/*drug effects
Animals ; Antioxidants/isolation & purification ; Apoptosis/drug effects ; Apoptosis Inducing Factor/metabolism ; Cells, Cultured ; Flavonoids/isolation & purification ; Histones/metabolism ; Mice, Knockout ; Oxidative Stress/radiation effects ; Poly (ADP-Ribose) Polymerase-1/deficiency ; Poly (ADP-Ribose) Polymerase-1/genetics ; Thymus Gland/metabolism ; Thymus Gland/pathology ; Thymus Gland/radiation effects ; Tumor Suppressor p53-Binding Protein 1/metabolism
Czasopismo naukowe

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