Autor: "Ting JP" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Identification of novel genes and transcription factors involved in spleen, thymus and immunological development and function
Autorzy:: Hoffman, B G
Williams, K L
Tien, A H
Lu, V
de Algara, T Ruiz
Ting, Jp-y
Helgason, C DAff1, Aff3, ID6364270_cor7; Pokaż więcej
Źródło:: Genes & Immunity. 7(2):101-112

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Skocz do pozycji: 3.

Tytuł:: Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements.
Autorzy:: Snouwaert JN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Jania LA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Nguyen T; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Martinez DR; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Schäfer A; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Catanzaro NJ; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Gully KL; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Baric RS; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Heise M; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Anderson E; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Pressey K; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Dillard JA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Taft-Benz S; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Baxter VK; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Ting JP; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Koller BH; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2023 Feb 22; Vol. 19 (2), pp. e1011168. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme 2*/genetics
COVID-19*/genetics
Receptors, Virus*/genetics
Animals ; Humans ; Mice ; Mice, Transgenic ; SARS-CoV-2 ; Viral Tropism

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Skocz do pozycji: 4.

Tytuł:: The innate immune receptor Nlrp12 suppresses autoimmunity to the retina.
Autorzy:: Lee EJ; VA Portland Health Care System, Portland, OR, USA.; Dept. of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.
Napier RJ; VA Portland Health Care System, Portland, OR, USA.; Dept. of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.
Vance EE; VA Portland Health Care System, Portland, OR, USA.; Dept. of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA.
Lashley SJ; VA Portland Health Care System, Portland, OR, USA.
Truax AD; Lineberger Comprehensive Cancer Center, University North Carolina, Chapel Hill, NC, USA.
Ting JP; Lineberger Comprehensive Cancer Center, Depts. Genetics and Microbiology-Immunology, University of North Carolina, Chapel Hill, NC, USA.
Rosenzweig HL; VA Portland Health Care System, Portland, OR, USA. .; Dept. of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, USA. .; Oregon Health & Science University, VA Portland Health Care System, 3710 SW US Veterans Hospital Rd., Bldg 103, Room E-222, Mail stop: VA R&D-14, Portland, OR, 97239, USA. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2022 Mar 21; Vol. 19 (1), pp. 69. Date of Electronic Publication: 2022 Mar 21.
Typ publikacji:: Journal Article
MeSH Terms:: Autoimmune Diseases*
Encephalomyelitis, Autoimmune, Experimental*/chemically induced
Encephalomyelitis, Autoimmune, Experimental*/pathology
Uveitis*/metabolism
Animals ; Autoimmunity ; Disease Models, Animal ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Immunity, Innate ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Retina/pathology ; Retinol-Binding Proteins ; Th17 Cells

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Skocz do pozycji: 5.

Tytuł:: Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases.
Autorzy:: Liu J; Protein Engineering, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, USA.
Ting JP; Protein Engineering, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, USA.
Al-Azzam S; Professional Scientific Services, Eurofins Lancaster Laboratories, Lancaster, PA 17605, USA.
Ding Y; Protein Engineering, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, USA.
Afshar S; Protein Engineering, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 10; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Autoimmune Diseases/*therapy
Diabetes Mellitus/*therapy
Nervous System Diseases/*therapy
Autoimmune Diseases/pathology ; Diabetes Mellitus/pathology ; Humans ; Nervous System Diseases/pathology

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Skocz do pozycji: 6.

Tytuł:: Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage.
Autorzy:: Pandya P; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Sayers RO; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Ting JP; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Morshedian S; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Torres C; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Cudal JS; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Zhang K; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Fitchett JR; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Zhang Q; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Zhang FF; Lilly Research Laboratories, Discovery Chemistry Research and Technologies, San Diego, California, United States of America.
Wang J; Lilly Research Laboratories, Discovery Chemistry Research and Technologies, San Diego, California, United States of America.
Durbin JD; Department of Structural Biology, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Carrillo JJ; Department of Quantitative Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Espada A; Centro de Investigación Lilly, Alcobendas, Spain.
Broughton H; Centro de Investigación Lilly, Alcobendas, Spain.
Qian Y; Lilly Research Laboratories, Recombinant Protein Generation, Indianapolis, Indiana, United States of America.
Afshar S; Department of Protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jun 01; Vol. 15 (6), pp. e0233961. Date of Electronic Publication: 2020 Jun 01 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Peptide Library*
Cell Surface Display Techniques/*methods
Alanine/genetics ; Alanine/metabolism ; Bacteriophages/genetics ; Bacteriophages/metabolism ; Cell Surface Display Techniques/economics ; Cost-Benefit Analysis ; Flow Cytometry/economics ; Flow Cytometry/methods ; Interleukin-12 Subunit p40/genetics ; Interleukin-12 Subunit p40/metabolism ; Mutation ; Protein Binding/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Reproducibility of Results ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism

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Skocz do pozycji: 7.

Tytuł:: NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.
Autorzy:: Gharagozloo M; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America.
Mahmoud S; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Simard C; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Yamamoto K; Department of Chemical Engineering and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Bobbala D; Department of Anatomy and Cell Biology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Ilangumaran S; Department of Anatomy and Cell Biology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Smith MD; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America.
Lamontagne A; Department of Neurology, Faculty of Medicine, MS Clinic, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Jarjoura S; Department of Neurology, Faculty of Medicine, MS Clinic, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Denault JB; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Blais V; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Gendron L; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Vilariño-Güell C; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Sadovnick AD; Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Ting JP; Department of Microbiology and Immunology, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Calabresi PA; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, United States of America.
Amrani A; Department of Pediatrics, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Gris D; Department of Pharmacology and Physiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2019 Sep 16; Vol. 17 (9), pp. e3000451. Date of Electronic Publication: 2019 Sep 16 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Encephalomyelitis, Autoimmune, Experimental/*etiology
Mitochondrial Proteins/*genetics
Mitochondrial Proteins/*physiology
Adult ; Animals ; Astrocytes/physiology ; Case-Control Studies ; Central Nervous System/pathology ; Codon, Nonsense ; Demyelinating Diseases ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Humans ; Immunity, Innate ; Male ; Mice, Transgenic ; Middle Aged ; Mutation, Missense ; Young Adult

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Skocz do pozycji: 8.

Tytuł:: Correction: Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome.
Autorzy:: Chung WC
Kang HR
Yoon H
Kang SJ
Ting JP
Song MJ; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Jul 10; Vol. 13 (7), pp. e0200624. Date of Electronic Publication: 2018 Jul 10 (Print Publication: 2018).
Typ publikacji:: Journal Article; Published Erratum

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Skocz do pozycji: 9.

Tytuł:: Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
Autorzy:: Ting JP; Department of protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.
Tung F; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America.
Antonysamy S; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America.
Wasserman S; Department of structural Biology, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Advanced Photon Source, Argonne, Illinois, United States of America.
Jones SB; Lilly Research Laboratories, Indianapolis, Indiana, United States of America.
Zhang FF; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America.
Espada A; Centro de Investigación Lilly, Alcobendas, Spain.
Broughton H; Centro de Investigación Lilly, Alcobendas, Spain.
Chalmers MJ; Lilly Research Laboratories, Indianapolis, Indiana, United States of America.
Woodman ME; Lilly Research Laboratories, Indianapolis, Indiana, United States of America.
Bina HA; Lilly Research Laboratories, Indianapolis, Indiana, United States of America.
Dodge JA; Lilly Research Laboratories, Indianapolis, Indiana, United States of America.
Benach J; Department of structural Biology, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Advanced Photon Source, Argonne, Illinois, United States of America.
Zhang A; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America.
Groshong C; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America.
Manglicmot D; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America.
Russell M; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America.
Afshar S; Department of protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Jan 12; Vol. 13 (1), pp. e0190850. Date of Electronic Publication: 2018 Jan 12 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Coliphages/*metabolism
Interleukin-17/*metabolism
Peptides/*metabolism
Receptors, Interleukin-17/*metabolism
Crystallography, X-Ray ; Enzyme-Linked Immunosorbent Assay ; HT29 Cells ; Humans ; Interleukin-17/chemistry ; Models, Molecular ; Receptors, Interleukin-17/chemistry ; Surface Plasmon Resonance

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Skocz do pozycji: 10.

Tytuł:: Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum.
Autorzy:: Chang TH; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.
Huang JH; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.
Lin HC; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.
Chen WY; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.
Lee YH; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.
Hsu LC; Graduate Institute of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Ting JP; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Wu-Hsieh BA; Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2017 Jul 03; Vol. 13 (7), pp. e1006485. Date of Electronic Publication: 2017 Jul 03 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Dendritic Cells/*immunology
Histoplasma/*physiology
Histoplasmosis/*immunology
Inflammasomes/*immunology
Lectins, C-Type/*immunology
NLR Family, Pyrin Domain-Containing 3 Protein/*immunology
Animals ; Caspase 1/genetics ; Caspase 1/immunology ; Dendritic Cells/microbiology ; Histoplasma/genetics ; Histoplasmosis/genetics ; Histoplasmosis/microbiology ; Humans ; Inflammasomes/genetics ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Lectins, C-Type/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics

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Skocz do pozycji: 11.

Tytuł:: NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency.
Autorzy:: Ma Z; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Hopcraft SE; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Yang F; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Petrucelli A; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Guo H; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Ting JP; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Dittmer DP; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
Damania B; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2017 May 01; Vol. 13 (5), pp. e1006350. Date of Electronic Publication: 2017 May 01 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: DNA Replication*
Virus Activation*
Castleman Disease/*virology
Herpesvirus 8, Human/*physiology
Lymphoma, Primary Effusion/*virology
Mitochondrial Proteins/*metabolism
Sarcoma, Kaposi/*virology
Cell Line ; Gene Expression Regulation ; Herpesvirus 8, Human/genetics ; Humans ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Mitochondrial Proteins/genetics ; Virus Latency
SCR Disease Name:: Multi-centric Castleman's Disease

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Skocz do pozycji: 12.

Tytuł:: MAVS-dependent host species range and pathogenicity of human hepatitis A virus.
Autorzy:: Hirai-Yuki A; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
Hensley L; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
McGivern DR; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Medicine, University of North Carolina, Chapel Hill, NC 27517, USA.
González-López O; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
Das A; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
Feng H; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
Sun L; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
Wilson JE; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Genetics, University of North Carolina, Chapel Hill, NC 27517, USA.
Hu F; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
Feng Z; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA.
Lovell W; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA.
Misumi I; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Genetics, University of North Carolina, Chapel Hill, NC 27517, USA.
Ting JP; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Genetics, University of North Carolina, Chapel Hill, NC 27517, USA.
Montgomery S; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27517, USA.
Cullen J; Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA.
Whitmire JK; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Genetics, University of North Carolina, Chapel Hill, NC 27517, USA.
Lemon SM; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Medicine, University of North Carolina, Chapel Hill, NC 27517, USA. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2016 Sep 30; Vol. 353 (6307), pp. 1541-1545. Date of Electronic Publication: 2016 Sep 15.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Disease Models, Animal*
Mice*
Adaptor Proteins, Signal Transducing/*immunology
Hepatitis A/*immunology
Hepatitis A virus/*immunology
Host-Pathogen Interactions/*immunology
Liver/*immunology
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Apoptosis ; Hepatitis A/pathology ; Hepatitis A/virology ; Hepatocytes/immunology ; Hepatocytes/pathology ; Hepatocytes/virology ; Humans ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/immunology ; Interferon Regulatory Factor-7/genetics ; Interferon Regulatory Factor-7/immunology ; Interferon Type I/immunology ; Liver/pathology ; Liver/virology ; Mice, Knockout ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/immunology ; Receptors, Interferon/genetics ; Receptors, Interferon/immunology ; Signal Transduction/immunology ; Species Specificity ; Interferon gamma Receptor

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Skocz do pozycji: 13.

Tytuł:: Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.
Autorzy:: Callaway JB; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Smith SA; The Vanderbilt Vaccine Center, Vanderbilt Medical Center, Nashville, TN, United States of America; Department of Medicine, Vanderbilt Medical Center, Nashville, TN, United States of America.
Widman DG; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
McKinnon KP; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Scholle F; Department of Biological Sciences, North Carolina State University, Raleigh, NC, United States of America.
Sempowski GD; Duke Human Vaccine Institute, Durham, NC, United States of America.
Dittmer DP; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Crowe JE Jr; The Vanderbilt Vaccine Center, Vanderbilt Medical Center, Nashville, TN, United States of America; Department of Pathology, Microbiology and Immunology, Vanderbilt Medical Center, Nashville, TN, United States of America; Department of Pediatrics, Vanderbilt Medical Center, Nashville, TN, United States of America.
de Silva AM; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Ting JP; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Aug 24; Vol. 10 (8), pp. e0136708. Date of Electronic Publication: 2015 Aug 24 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Antibodies, Viral/*immunology
Dengue Virus/*immunology
Interleukin-1beta/*metabolism
Severe Dengue/*immunology
Animals ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Viral/administration & dosage ; Chlorocebus aethiops ; Dengue Virus/pathogenicity ; Humans ; Interleukin-1beta/immunology ; Monocytes/immunology ; Monocytes/virology ; Severe Dengue/virology ; Vero Cells ; Virus Replication/immunology

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Skocz do pozycji: 14.

Tytuł:: NLRP3 moonlights in TH2 polarization.
Autorzy:: Ting JP; Lineberger Comprehensive Cancer Center, Departments of Genetics, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Harton JA; Center for Immunology &Microbial Disease, Albany Medical College, Albany, New York, USA.; Pokaż więcej
Źródło:: Nature immunology [Nat Immunol] 2015 Aug; Vol. 16 (8), pp. 794-6.
Typ publikacji:: Journal Article; Comment
MeSH Terms:: Carrier Proteins/*immunology
Cell Differentiation/*immunology
Th2 Cells/*immunology
Trans-Activators/*immunology
Animals ; Female

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Skocz do pozycji: 15.

Tytuł:: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Autorzy:: Wilson JE; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Petrucelli AS; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Chen L; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Koblansky AA; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Truax AD; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Oyama Y; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Rogers AB; Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Brickey WJ; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Wang Y; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Schneider M; The American Association of Immunologists, Bethesda, Maryland, USA.
Mühlbauer M; 1] Department of Medicine, Division of Gastroenterology, University of Florida College of Medicine, Gainesville, Florida, USA. [2] Department of Infectious Diseases &Pathology, University of Florida College of Medicine, Gainesville, Florida, USA.
Chou WC; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Barker BR; Department of Biology, Drew University, Madison, New Jersey, USA.
Jobin C; 1] Department of Medicine, Division of Gastroenterology, University of Florida College of Medicine, Gainesville, Florida, USA. [2] Department of Infectious Diseases &Pathology, University of Florida College of Medicine, Gainesville, Florida, USA.
Allbritton NL; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ramsden DA; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, USA.
Davis BK; Department of Biology, Franklin &Marshall College, Lancaster, Pennsylvania, USA.
Ting JP; 1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.; Pokaż więcej
Źródło:: Nature medicine [Nat Med] 2015 Aug; Vol. 21 (8), pp. 906-13. Date of Electronic Publication: 2015 Jun 24.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Colonic Neoplasms/*prevention & control
DNA-Activated Protein Kinase/*physiology
DNA-Binding Proteins/*physiology
Inflammasomes/*physiology
Proto-Oncogene Proteins c-akt/*physiology
Animals ; Colitis/complications ; Female ; HCT116 Cells ; Humans ; Intestinal Polyps/prevention & control ; Male ; Mice ; Mice, Inbred C57BL ; Phosphorylation

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Skocz do pozycji: 16.

Tytuł:: Inflammasomes: mechanism of action, role in disease, and therapeutics.
Autorzy:: Guo H; The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Callaway JB; The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ting JP; 1] The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Pokaż więcej
Źródło:: Nature medicine [Nat Med] 2015 Jul; Vol. 21 (7), pp. 677-87. Date of Electronic Publication: 2015 Jun 29.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Disease*
Molecular Targeted Therapy*
Inflammasomes/*metabolism
Animals ; Disease Models, Animal ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Models, Immunological

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Skocz do pozycji: 17.

Tytuł:: Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome.
Autorzy:: Chung WC; Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea.
Kang HR; Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea.
Yoon H; Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea; Laboratory of Protein Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, 110-744, Republic of Korea.
Kang SJ; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of Korea.
Ting JP; Departments of Genetics, Microbiology and Immunology, Center for Translational Immunology and Inflammatory Disease Institute, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, United States of America.
Song MJ; Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 May 15; Vol. 10 (5), pp. e0126456. Date of Electronic Publication: 2015 May 15 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Carrier Proteins/*metabolism
Inflammasomes/*metabolism
Influenza A virus/*metabolism
Viral Nonstructural Proteins/*metabolism
Adenosine Triphosphate/metabolism ; Blotting, Western ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique ; Humans ; Immunoprecipitation ; Inflammasomes/drug effects ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Microscopy, Confocal ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein ; Real-Time Polymerase Chain Reaction

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Skocz do pozycji: 18.

Tytuł:: ASC deficiency suppresses proliferation and prevents medulloblastoma incidence.
Autorzy:: Knight ER; 1] Neurobiology Curriculum, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [2] Neuroscience Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Patel EY; Neuroscience Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Flowers CA; Neuroscience Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Crowther AJ; 1] Neuroscience Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [2] Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Ting JP; 1] Neurobiology Curriculum, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [2] Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [3] Department of Microbiology and Immunology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Miller CR; 1] Neuroscience Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [2] Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [3] Department of Pathology and Laboratory Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [4] Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Gershon TR; 1] Neurobiology Curriculum, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [2] Neuroscience Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [3] Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [4] Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Deshmukh M; 1] Neurobiology Curriculum, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [2] Neuroscience Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [3] Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA [4] Department of Cell Biology and Physiology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.; Pokaż więcej
Źródło:: Oncogene [Oncogene] 2015 Jan 15; Vol. 34 (3), pp. 394-402. Date of Electronic Publication: 2014 Jan 27.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Proliferation*
Apoptosis Regulatory Proteins/*genetics
Cerebellar Neoplasms/*genetics
Medulloblastoma/*genetics
Adolescent ; Adult ; Animals ; Apoptosis Regulatory Proteins/deficiency ; CARD Signaling Adaptor Proteins ; Cerebellar Neoplasms/metabolism ; Cerebellar Neoplasms/pathology ; Child ; Child, Preschool ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; In Situ Hybridization ; Infant ; Male ; Medulloblastoma/metabolism ; Medulloblastoma/pathology ; Mice, Knockout ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Young Adult