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Wyświetlanie 1-8 z 8
Tytuł :
Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR.
Autorzy :
Tippin BL; Department of Pediatrics, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California.
Kwong AM
Inadomi MJ
Lee OJ
Park JM
Materi AM
Buslon VS
Lin AM
Kudo LC
Karsten SL
French SW
Narumiya S
Urade Y
Salido E
Lin HJ
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Źródło :
Cancer medicine [Cancer Med] 2014 Aug; Vol. 3 (4), pp. 1041-51. Date of Electronic Publication: 2014 Apr 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenoma/*genetics
Intestinal Neoplasms/*genetics
Prostaglandin D2/*physiology
Receptors, Immunologic/*metabolism
Receptors, Prostaglandin/*metabolism
Adenoma/metabolism ; Adenoma/pathology ; Adenomatous Polyposis Coli Protein/genetics ; Adenomatous Polyposis Coli Protein/metabolism ; Animals ; Female ; Gene Expression ; Humans ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Intramolecular Oxidoreductases ; Isomerases/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; PPAR gamma/genetics ; Prostaglandin-Endoperoxide Synthases/genetics ; Prostaglandin-Endoperoxide Synthases/metabolism ; Receptors, Immunologic/genetics ; Receptors, Prostaglandin/genetics ; Tumor Burden ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of α-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts.
Autorzy :
Kan SH; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Troitskaya LA; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Sinow CS; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Haitz K; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Todd AK; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Di Stefano A; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Le SQ; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Dickson PI; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
Tippin BL; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, U.S.A.
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Źródło :
The Biochemical journal [Biochem J] 2014 Mar 01; Vol. 458 (2), pp. 281-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetylglucosaminidase/*genetics
Fibroblasts/*metabolism
Insulin-Like Growth Factor II/*genetics
Lysosomes/*genetics
Mucopolysaccharidosis III/*metabolism
Acetylglucosaminidase/biosynthesis ; Acetylglucosaminidase/metabolism ; Amino Acid Motifs/genetics ; Animals ; Binding Sites/genetics ; CHO Cells ; Cell Line, Tumor ; Cricetinae ; Cricetulus ; Endocytosis/genetics ; Fibroblasts/enzymology ; Fibroblasts/pathology ; Humans ; Lysosomes/enzymology ; Lysosomes/metabolism ; Mucopolysaccharidosis III/enzymology ; Mucopolysaccharidosis III/genetics ; Protein Binding/genetics ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Mannose 6-phosphate conjugation is not sufficient to allow induction of immune tolerance to phenylalanine ammonia-lyase in dogs.
Autorzy :
Vera M; Department of Pediatrics, Division of Medical Genetics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W Carson St HH1, Torrance, CA, 90502, USA, .
Lester T
Zhao B
Tiger P
Clarke S
Tippin BL
Passage MB
Le SQ
Femenia J
Lemontt JF
Kakkis ED
Dickson PI
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Źródło :
JIMD reports [JIMD Rep] 2013; Vol. 8, pp. 63-72. Date of Electronic Publication: 2012 Jul 06.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.
Autorzy :
Tippin BL; Division of Medical Genetics, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA.
Levine AJ
Materi AM
Song WL
Keku TO
Goodman JE
Sansbury LB
Das S
Dai A
Kwong AM
Lin AM
Lin JM
Park JM
Patterson RE
Chlebowski RT
Garavito RM
Inoue T
Cho W
Lawson JA
Kapoor S
Kolonel LN
Le Marchand L
Haile RW
Sandler RS
Lin HJ
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Źródło :
Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2012 Jan; Vol. 97 (1-2), pp. 22-8. Date of Electronic Publication: 2011 Jul 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amino Acid Substitution*
African Americans/*genetics
Colorectal Neoplasms/*enzymology
Colorectal Neoplasms/*genetics
Genetic Predisposition to Disease/*genetics
Intramolecular Oxidoreductases/*chemistry
Intramolecular Oxidoreductases/*genetics
Lipocalins/*chemistry
Lipocalins/*genetics
Adult ; Animals ; Case-Control Studies ; Colorectal Neoplasms/ethnology ; Enzyme Stability ; Gene Knockout Techniques ; Humans ; Intramolecular Oxidoreductases/deficiency ; Isoenzymes/chemistry ; Isoenzymes/deficiency ; Isoenzymes/genetics ; Mice ; Models, Molecular ; Protein Conformation ; Transgenes/genetics
Czasopismo naukowe
Tytuł :
Biochemical characterization of fluorescent-labeled recombinant human alpha-L-iduronidase in vitro.
Autorzy :
Tippin BL; Division of Medical Genetics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Troitskaya L
Kan SH
Todd AK
Le SQ
Dickson PI
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Źródło :
Biotechnology and applied biochemistry [Biotechnol Appl Biochem] 2011 Nov-Dec; Vol. 58 (6), pp. 391-6. Date of Electronic Publication: 2011 Oct 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Iduronidase/*analysis
Iduronidase/*metabolism
Lysosomes/*enzymology
Cells, Cultured ; Fibroblasts/metabolism ; Fluorescent Dyes/chemistry ; Glycosaminoglycans/metabolism ; Humans ; Iduronidase/chemistry ; Molecular Weight ; Mucopolysaccharidosis I/enzymology ; Receptor, IGF Type 2/metabolism ; Recombinant Proteins/analysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.
Autorzy :
Kwong AM; Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90502, USA.
Tippin BL
Materi AM
Buslon VS
French SW
Lin HJ
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Źródło :
Nutrition and cancer [Nutr Cancer] 2011; Vol. 63 (6), pp. 950-9. Date of Electronic Publication: 2011 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Diet*
Neoplasms/*pathology
Niacin/*administration & dosage
Prostaglandins/*urine
Adenoma/pathology ; Animals ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Dose-Response Relationship, Drug ; Female ; Flushing ; Humans ; Intestines/pathology ; Intramolecular Oxidoreductases ; Isomerases/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplasms, Experimental/chemically induced ; Neoplasms, Experimental/pathology ; Phospholipases A2, Cytosolic/metabolism ; RNA, Messenger/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Nicotinic/genetics ; Receptors, Nicotinic/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I.
Autorzy :
Dickson PI; Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA. />Hanson S
McEntee MF
Vite CH
Vogler CA
Mlikotic A
Chen AH
Ponder KP
Haskins ME
Tippin BL
Le SQ
Passage MB
Guerra C
Dierenfeld A
Jens J
Snella E
Kan SH
Ellinwood NM
Pokaż więcej
Źródło :
Molecular genetics and metabolism [Mol Genet Metab] 2010 Oct-Nov; Vol. 101 (2-3), pp. 115-22. Date of Electronic Publication: 2010 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Enzyme Replacement Therapy/*veterinary
Iduronidase/*therapeutic use
Mucopolysaccharidosis I/*drug therapy
Mucopolysaccharidosis I/*veterinary
Spinal Cord Compression/*drug therapy
Spinal Cord Compression/*veterinary
Animals ; Dogs ; Humans ; Injections, Spinal ; Magnetic Resonance Imaging/veterinary ; Spinal Cord/pathology ; Spinal Cord Compression/pathology
Czasopismo naukowe
Tytuł :
Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice.
Autorzy :
Park JM; Division of Medical Genetics, Department of Pediatrics and Department of Pathology, Los Angeles Biomedical Research Institute, Harbor-University of California-Los Angeles Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.
Kanaoka Y
Eguchi N
Aritake K
Grujic S
Materi AM
Buslon VS
Tippin BL
Kwong AM
Salido E
French SW
Urade Y
Lin HJ
Pokaż więcej
Źródło :
Cancer research [Cancer Res] 2007 Feb 01; Vol. 67 (3), pp. 881-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenomatous Polyposis Coli/*enzymology
Hematopoietic System/*enzymology
Intramolecular Oxidoreductases/*deficiency
Intramolecular Oxidoreductases/*metabolism
Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/urine ; Animals ; Dinoprost/urine ; Female ; Intramolecular Oxidoreductases/biosynthesis ; Intramolecular Oxidoreductases/genetics ; Lipocalins ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Prostaglandin D2/biosynthesis ; Prostaglandins/urine
Czasopismo naukowe
    Wyświetlanie 1-8 z 8

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