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Wyszukujesz frazę ""Tissue Distribution"" wg kryterium: Temat


Tytuł:
Physiologically-based pharmacokinetic model for evaluating gender-specific exposures of N-nitrosodimethylamine (NDMA).
Autorzy:
Kang DW; College of Pharmacy, CHA University, 335 Pangyo-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13488, Republic of Korea.
Kim JH; College of Pharmacy, CHA University, 335 Pangyo-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13488, Republic of Korea.
Choi GW; College of Pharmacy, CHA University, 335 Pangyo-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13488, Republic of Korea.
Cho SJ; College of Pharmacy, CHA University, 335 Pangyo-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13488, Republic of Korea.
Cho HY; College of Pharmacy, CHA University, 335 Pangyo-Ro, Bundang-Gu, Seongnam-Si, Gyeonggi-Do, 13488, Republic of Korea. .
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Źródło:
Archives of toxicology [Arch Toxicol] 2024 Mar; Vol. 98 (3), pp. 821-835. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Dimethylnitrosamine*/toxicity
Carcinogens*/toxicity
Rats ; Humans ; Animals ; Tissue Distribution ; Lung ; Liver ; Models, Biological
Czasopismo naukowe
Tytuł:
Novel l-Cysteine Incomplete Degradation Method for Preparation of Procyanidin B2-3'- O -Gallate and Exploration of its in Vitro Anti-inflammatory Activity and in Vivo Tissue Distribution.
Autorzy:
Yu Y; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zuo C; National Engineering Research Center of Pharmaceutics of Traditional Chinese Medicine, Benxi 117004, China.; Shenzhen Chinese Medicine Manufacturing Innovation Center Co., Shenzhen 518109, China.
Li M; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Tang Y; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li L; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang F; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang S; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Sun B; School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.; Pólo Dois Portos, Instituto National de Investigação Agrária e Veterinária, I.P., Quinta da Almoinha, 2565-191 Dois Portos, Portugal.
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Źródło:
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Feb 28; Vol. 72 (8), pp. 4023-4034. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Proanthocyanidins*/pharmacology
Proanthocyanidins*/chemistry
Biflavonoids*/pharmacology
Biflavonoids*/chemistry
Catechin*/chemistry
Humans ; Cysteine ; Tissue Distribution ; Inflammation ; Anti-Inflammatory Agents/pharmacology
Czasopismo naukowe
Tytuł:
UHPLC-MS/MS Assay for Quantification of Legubicin, a Novel Doxorubicin-Based Legumain-Activated Prodrug, and Its Application to Pharmacokinetic and Tissue Distribution Studies.
Autorzy:
Ma L; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.; Shanghai Innostar Bio-Tech Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Yu Q; Shanghai Innostar Bio-Tech Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Zhuang M; Shanghai Innostar Bio-Tech Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Yang C; Shanghai Innostar Bio-Tech Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Liu Y; Shanghai Affinity Bio-Pharmaceuticals Co., Ltd., Shanghai 201203, China.
Li Y; Shanghai Affinity Bio-Pharmaceuticals Co., Ltd., Shanghai 201203, China.
Liu C; Shanghai Affinity Bio-Pharmaceuticals Co., Ltd., Shanghai 201203, China.
Shen X; Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Chang Y; Shanghai Innostar Bio-Tech Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 08; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Prodrugs*/chemistry
Neoplasms*
Cysteine Endopeptidases*
Mice ; Rats ; Animals ; Chromatography, High Pressure Liquid ; Tissue Distribution ; Tandem Mass Spectrometry ; Doxorubicin/chemistry ; Albumins
Czasopismo naukowe
Tytuł:
In vivo pharmacokinetic study of vanillic acid in monocrotaline-induced pulmonary arterial hypertension rats and its tissue distribution.
Autorzy:
A X; Medical College of Qinghai University, Xining, China.; Xining Customs Technical Center, Key Laboratory of Food Safety Research in Qinghai Province, Xining, Qinghai, China.
Huayu M; Research Center for High Altitude Medicine, Key Laboratory for High Altitude Medicine (Ministry of Education), Laboratory for High Altitude Medicine of Qinghai Province, Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Qinghai University, Xining, Qinghai, China.
Li Z; Medical College of Qinghai University, Xining, China.; Research Center for High Altitude Medicine, Key Laboratory for High Altitude Medicine (Ministry of Education), Laboratory for High Altitude Medicine of Qinghai Province, Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Qinghai University, Xining, Qinghai, China.
Su S; Xining Customs Technical Center, Key Laboratory of Food Safety Research in Qinghai Province, Xining, Qinghai, China.
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Źródło:
Biomedical chromatography : BMC [Biomed Chromatogr] 2024 Feb; Vol. 38 (2), pp. e5793. Date of Electronic Publication: 2023 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
Vanillic Acid*
Pulmonary Arterial Hypertension*/chemically induced
Rats ; Animals ; Rats, Sprague-Dawley ; Chromatography, High Pressure Liquid/methods ; Monocrotaline ; Tissue Distribution ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł:
Study on the Anti-Ulcerative Colitis Effect of Pseudo-Ginsenoside RT4 Based on Gut Microbiota, Pharmacokinetics, and Tissue Distribution.
Autorzy:
Yu H; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Wang C; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Wu J; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Wang Q; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Liu H; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Li Z; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
He S; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Wang C; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.; Research Center of Natural Drug, Jilin University, Changchun 130021, China.
Liu J; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.; Research Center of Natural Drug, Jilin University, Changchun 130021, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 09; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Gastrointestinal Microbiome*
Ginsenosides*
Colitis, Ulcerative*/chemically induced
Colitis, Ulcerative*/drug therapy
Animals ; Mice ; Humans ; Tissue Distribution ; Caco-2 Cells ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Cytokines ; Interleukin-1beta ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł:
Pharmacokinetic, Tissue Distribution, Metabolite, and Toxicity Evaluation of the Matrine Derivative, (6aS, 10S, 11aR, 11bR, 11cS)-10-Methylaminododecahydro-3a, 7a-Diaza-benzo (de) Anthracene-8-thione.
Autorzy:
Li L; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.
Lu F; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.; Department of Pharmacy, Ningxia Health Vocational and Technical College, Intersection of Starlight Avenue and Xueyuan Road, Shizuishan 753000, China.
Ding S; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.
Wang X; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.
Wang W; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.
Zhang W; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Xu W; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Zhuang C; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Miao Z; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Ma X; Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 06; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Matrines*
Anthracenes*
Thiones*
Mice ; Rats ; Animals ; Carbon Radioisotopes ; Tissue Distribution
Czasopismo naukowe
Tytuł:
Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS.
Autorzy:
Lei P; Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.; Hubei Hongshan Laboratory, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Shen W; Hubei Hongshan Laboratory, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Tang H; Hubei Hongshan Laboratory, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
You L; Hubei Hongshan Laboratory, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Chen G; Hubei Hongshan Laboratory, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Tang Y; Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
Lu W; Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
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Źródło:
Drug design, development and therapy [Drug Des Devel Ther] 2024 Jan 05; Vol. 18, pp. 1-12. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins p21(ras)*
Liquid Chromatography-Mass Spectrometry*
Acetonitriles*
Piperazines*
Pyrimidines*
Rats ; Animals ; Rats, Sprague-Dawley ; Biological Availability ; Tissue Distribution ; Chromatography, Liquid ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł:
Review of Zinc Oxide Nanoparticles: Toxicokinetics, Tissue Distribution for Various Exposure Routes, Toxicological Effects, Toxicity Mechanism in Mammals, and an Approach for Toxicity Reduction.
Autorzy:
Fujihara J; Department of Legal Medicine, Shimane University Faculty of Medicine, 89-1 Enya, Izumo , Shimane, 693-8501, Japan. .
Nishimoto N; Department of Research Planning and Coordination, Shimane Institute for Industrial Technology, 1 Hokuryo, Matsue, Shimane, 690-0816, Japan.
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Źródło:
Biological trace element research [Biol Trace Elem Res] 2024 Jan; Vol. 202 (1), pp. 9-23. Date of Electronic Publication: 2023 Mar 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Zinc Oxide*/toxicity
Nanoparticles*/toxicity
Animals ; Reactive Oxygen Species/metabolism ; Toxicokinetics ; Tissue Distribution ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Enhanced tissue distribution of ritonavir-loaded nanostructured lipid carriers-recommending its dose reduction.
Autorzy:
Jitta SR; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576 104, Udupi, Karnataka, India.
Salwa; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576 104, Udupi, Karnataka, India.
Bhaskaran NA; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576 104, Udupi, Karnataka, India.
Marques SM; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576 104, Udupi, Karnataka, India.
Kumar L; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576 104, Udupi, Karnataka, India. .; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, 844 102, Vaishali, Bihar, India. .
Cheruku SP; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576 104, Udupi, Karnataka, India.
Rao V; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576 104, Udupi, Karnataka, India.
Sharma P; Department of Pharmacy, Birla Institute of Technology & Science - Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad, 500 078, Telangana State, India.
Kulkarni OP; Department of Pharmacy, Birla Institute of Technology & Science - Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad, 500 078, Telangana State, India.
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Źródło:
Drug delivery and translational research [Drug Deliv Transl Res] 2024 Jan; Vol. 14 (1), pp. 116-130. Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:
Journal Article
MeSH Terms:
Nanostructures*
HIV Infections*/drug therapy
Rats ; Humans ; Animals ; Ritonavir/therapeutic use ; Tissue Distribution ; Rats, Wistar ; Drug Tapering ; Cycloheximide/therapeutic use ; Lipids ; Drug Carriers ; Particle Size
Czasopismo naukowe
Tytuł:
Tissue distribution of metabolites in Cordyceps cicadae determined by DESI-MSI analysis.
Autorzy:
Cao M; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
Wu J; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
Zhu X; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
Jia Z; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
Zhou Y; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
Yu L; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
Hu C; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China. .
Gao Y; International Education College, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China. .
Chen Z; Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China. .
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2024 Mar; Vol. 416 (8), pp. 1883-1906. Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cordyceps*/chemistry
Cordyceps*/metabolism
Tissue Distribution ; Mass Spectrometry ; Nucleosides/chemistry ; Fatty Acids/metabolism ; Amino Acids/metabolism ; Spectrometry, Mass, Electrospray Ionization/methods
SCR Organism:
Cordyceps cicadae
Czasopismo naukowe
Tytuł:
Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo.
Autorzy:
Walther J; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99 3584 CG, Utrecht, the Netherlands.
Porenta D; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99 3584 CG, Utrecht, the Netherlands; Department of Infectious Diseases and immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL, Utrecht, the Netherlands.
Wilbie D; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99 3584 CG, Utrecht, the Netherlands.
Seinen C; CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.
Benne N; Department of Infectious Diseases and immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL, Utrecht, the Netherlands.
Yang Q; Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands; CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.
de Jong OG; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99 3584 CG, Utrecht, the Netherlands.
Lei Z; Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands; CDL Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.
Mastrobattista E; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99 3584 CG, Utrecht, the Netherlands. Electronic address: .
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Źródło:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2024 Mar; Vol. 196, pp. 114207. Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Editing*/methods
Nanoparticles*
Liposomes*
Humans ; Female ; Mice ; Animals ; CRISPR-Cas Systems ; CRISPR-Associated Protein 9/genetics ; RNA, Guide, CRISPR-Cas Systems ; RNA, Messenger/genetics ; HEK293 Cells ; Tissue Distribution ; DNA
Czasopismo naukowe
Tytuł:
Pharmacokinetics, biodistribution, and in vivo toxicity of 7-nitroindazole loaded in pegylated and non-pegylated nanoemulsions in rats.
Autorzy:
França AP; Pharmacy Graduate Program, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil. Electronic address: .
Silva TA; Pharmacy Graduate Program, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Schulz D; Pharmacy Graduate Program, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Gomes-Pereira L; Pharmacology Graduate Program, Department of Pharmacology, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Cunha LMA; Pharmacology Graduate Program, Department of Pharmacology, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Gonçalves MP; Pharmacology Graduate Program, Department of Pharmacology, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Vieira JVS; Pharmacy Graduate Program, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Sanches MP; Pharmacy Graduate Program, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Koehler N; Citogenetics and Genomic Stability Laboratory, University Hospital Polydoro Ernani de São Thiago, Federal University of Santa Catarina, Florianopolis, SC, 88040-900, Brazil.
Maluf S; Citogenetics and Genomic Stability Laboratory, University Hospital Polydoro Ernani de São Thiago, Federal University of Santa Catarina, Florianopolis, SC, 88040-900, Brazil.
Poli A; Pharmacology Graduate Program, Department of Pharmacology, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
da Silva-Santos JE; Pharmacology Graduate Program, Department of Pharmacology, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Assreuy J; Pharmacology Graduate Program, Department of Pharmacology, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil.
Lemos-Senna E; Pharmacy Graduate Program, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Campus Trindade, Florianópolis, SC, 88040-900, Brazil. Electronic address: .
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Źródło:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Mar 01; Vol. 194, pp. 106695. Date of Electronic Publication: 2024 Jan 07.
Typ publikacji:
Journal Article
MeSH Terms:
Nitric Oxide Synthase*/metabolism
Sepsis*
Rats ; Animals ; Rats, Wistar ; Tissue Distribution ; Indazoles/toxicity ; Indazoles/pharmacokinetics ; Polyethylene Glycols/toxicity ; Enzyme Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
Aerosol delivery and spatiotemporal tissue distribution of hydroxychloroquine in rat lung.
Autorzy:
Xia W; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
Kolli AR; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, Neuchâtel CH-2000, Switzerland. Electronic address: .
Kuczaj AK; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, Neuchâtel CH-2000, Switzerland.
Szostak J; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, Neuchâtel CH-2000, Switzerland.
Lam S; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
Toh WW; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
Purwanti A; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
Tan WT; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
Ng R; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
Phillips B; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
Peitsch MC; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, Neuchâtel CH-2000, Switzerland.
Hoeng J; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, Neuchâtel CH-2000, Switzerland.
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Źródło:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Mar 01; Vol. 194, pp. 106693. Date of Electronic Publication: 2024 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Hydroxychloroquine*/metabolism
Nebulizers and Vaporizers*
Rats ; Animals ; Tissue Distribution ; Aerosols ; Administration, Inhalation ; Lung/metabolism ; Drug Delivery Systems
Czasopismo naukowe
Tytuł:
Nonclinical safety assessment of an mRNA Covid-19 vaccine candidate following repeated administrations and biodistribution.
Autorzy:
Broudic K; Research and Development, Sanofi, Marcy l'Etoile, France.
Laurent S; Research and Development, Sanofi, Montpellier Cedex, France.
Perkov V; Research and Development, Sanofi, Marcy l'Etoile, France.
Simon C; Research and Development, Sanofi, Marcy l'Etoile, France.
Garinot M; Research and Development, Sanofi, Marcy l'Etoile, France.
Truchot N; France Safety Assessment SAS, Charles River Laboratories, Saint-Germain-Nuelles, France.
Latour J; Research and Development, Sanofi, Marcy l'Etoile, France.
Désert P; Research and Development, Sanofi, Marcy l'Etoile, France.
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Źródło:
Journal of applied toxicology : JAT [J Appl Toxicol] 2024 Mar; Vol. 44 (3), pp. 371-390. Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19 Vaccines*/adverse effects
COVID-19*/prevention & control
Spike Glycoprotein, Coronavirus*
Humans ; Rabbits ; Animals ; Mice ; Tissue Distribution ; SARS-CoV-2 ; RNA, Messenger ; Luciferases ; Lipids
Czasopismo naukowe
Tytuł:
Extravascular factor IX pool fed by prophylaxis is a true hemostatic barrier against bleeding.
Autorzy:
Leuci A; UR4609 Hémostase et Thrombose, Université Claude Bernard Lyon 1, Lyon, France.
Enjolras N; UR4609 Hémostase et Thrombose, Université Claude Bernard Lyon 1, Lyon, France.
Marano M; UR4609 Hémostase et Thrombose, Université Claude Bernard Lyon 1, Lyon, France.
Daniel M; UR4609 Hémostase et Thrombose, Université Claude Bernard Lyon 1, Lyon, France.
Brevet M; Cypath, Villeurbanne, France.
Connes P; Laboratoire interuniversitaire de Biologie de la Motricité EA7424, Team Vascular Biology and Red Blood Cell, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Dargaud Y; UR4609 Hémostase et Thrombose, Université Claude Bernard Lyon 1, Lyon, France; Centre de Référence de l'Hémophilie, Unité d'Hémostase Clinique, Hospices Civils de Lyon, Lyon, France. Electronic address: .
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Źródło:
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Mar; Vol. 22 (3), pp. 700-708. Date of Electronic Publication: 2023 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Hemophilia B*/drug therapy
Hemostatics*/therapeutic use
Mice ; Animals ; Factor IX/metabolism ; Collagen Type IV/metabolism ; Tissue Distribution ; Hemorrhage/prevention & control ; Hemorrhage/drug therapy ; Mice, Knockout
Czasopismo naukowe
Tytuł:
Low cost, high temporal resolution optical fiber-based γ-photon sensor for real-time pre-clinical evaluation of cancer-targeting radiopharmaceuticals.
Autorzy:
Lall R; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, 94720, USA. Electronic address: .
Lee K; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94107, USA.
Chopra S; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94107, USA.
Kandala A; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, 94720, USA.
Evans M; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94107, USA.
Seo Y; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94107, USA.
Niknejad A; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, 94720, USA.
Anwar M; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, 94720, USA; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94107, USA.
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Źródło:
Biosensors & bioelectronics [Biosens Bioelectron] 2024 Mar 01; Vol. 247, pp. 115956. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Biosensing Techniques*
Prostatic Neoplasms*/diagnostic imaging
Prostatic Neoplasms*/pathology
Male ; Animals ; Mice ; Humans ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/metabolism ; Radiopharmaceuticals/therapeutic use ; Glutamate Carboxypeptidase II ; Tissue Distribution ; Optical Fibers ; Prostate-Specific Antigen ; Lutetium/chemistry
Czasopismo naukowe
Tytuł:
Structural modifications toward improved lead-203/lead-212 peptide-based image-guided alpha-particle radiopharmaceutical therapies for neuroendocrine tumors.
Autorzy:
Lee D; Department of Physics and Chemistry, Korea Military Academy, Seoul, Republic of Korea.
Li M; Perspective Therapeutics, Inc., Coralville, IA, USA.
Liu D; Perspective Therapeutics, Inc., Coralville, IA, USA.
Baumhover NJ; Perspective Therapeutics, Inc., Coralville, IA, USA.
Sagastume EA; Perspective Therapeutics, Inc., Coralville, IA, USA.
Marks BM; Perspective Therapeutics, Inc., Coralville, IA, USA.
Rastogi P; Department of Pathology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Pigge FC; Department of Chemistry, The University of Iowa, ML B180 FRRBP, 500 Newton Road, Iowa City, IA, 52240, USA.
Menda Y; Department of Radiology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Johnson FL; Perspective Therapeutics, Inc., Coralville, IA, USA.
Schultz MK; Perspective Therapeutics, Inc., Coralville, IA, USA. .; Department of Chemistry, The University of Iowa, ML B180 FRRBP, 500 Newton Road, Iowa City, IA, 52240, USA. .; Department of Radiology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA. .; Department of Radiation Oncology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA. .
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Mar; Vol. 51 (4), pp. 1147-1162. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article
MeSH Terms:
Octreotide*/therapeutic use
Octreotide*/metabolism
Neuroendocrine Tumors*/diagnostic imaging
Neuroendocrine Tumors*/radiotherapy
Neuroendocrine Tumors*/drug therapy
Mice ; Humans ; Animals ; Radiopharmaceuticals/therapeutic use ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution ; Lead ; Lead Radioisotopes ; Receptors, Somatostatin/metabolism ; Chelating Agents
Czasopismo naukowe
Tytuł:
Noninvasive longitudinal PET/CT imaging of CAR T cells using PSMA reporter gene.
Autorzy:
Song X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei Province, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, China.
Zhang Y; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lv X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei Province, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, China.
Xu Z; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Long Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei Province, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, China.
Gai Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei Province, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, China.
Jiang D; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, China.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei Province, China.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, China.
Lei P; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lan X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, China. xiaoli_.; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei Province, China. xiaoli_.; Key Laboratory of Biological Targeted Therapy, The Ministry of Education, Wuhan, China. xiaoli_.
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Mar; Vol. 51 (4), pp. 965-977. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Journal Article
MeSH Terms:
Positron Emission Tomography Computed Tomography*/methods
Prostatic Neoplasms*/diagnostic imaging
Prostatic Neoplasms*/genetics
Prostatic Neoplasms*/metabolism
Male ; Humans ; Gallium Radioisotopes ; Tissue Distribution ; Genes, Reporter
Czasopismo naukowe
Tytuł:
Engineering poly(ethylene glycol) particles for targeted drug delivery.
Autorzy:
Li S; School of Science, RMIT University, Melbourne, Victoria 3000, Australia. .; Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Ma Y; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cui J; Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
Caruso F; Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Ju Y; School of Science, RMIT University, Melbourne, Victoria 3000, Australia. .; Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
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Źródło:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Feb 29; Vol. 60 (19), pp. 2591-2604. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Polyethylene Glycols*/chemistry
Drug Delivery Systems*
Tissue Distribution ; Polymers ; Engineering ; Drug Carriers/chemistry
Czasopismo naukowe
Tytuł:
Effect of Lipid Corona on Phenylalanine-Functionalized Gold Nanoparticles to Develop Stable and Corona-Free Systems.
Autorzy:
Tabassum H; Indian Institute of Technology Indore, Department of Chemistry, Indore 453552, Madhya Pradesh, India.
Maity A; Indian Institute of Technology Indore, Department of Chemistry, Indore 453552, Madhya Pradesh, India.
Singh K; Indian Institute of Technology Indore, Department of Chemistry, Indore 453552, Madhya Pradesh, India.
Bagchi D; Indian Institute of Technology Indore, Department of Chemistry, Indore 453552, Madhya Pradesh, India.
Prasad A; Indian Institute of Technology Indore, Department of Chemistry, Indore 453552, Madhya Pradesh, India.
Chakraborty A; Indian Institute of Technology Indore, Department of Chemistry, Indore 453552, Madhya Pradesh, India.
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Źródło:
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2024 Feb 27; Vol. 40 (8), pp. 4531-4543. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Metal Nanoparticles*/chemistry
Nanoparticles*/chemistry
Protein Corona*/chemistry
Humans ; Gold/chemistry ; Phenylalanine ; Tissue Distribution ; Proteins ; Lipids
Czasopismo naukowe

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