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Wyszukujesz frazę ""Tissue Distribution"" wg kryterium: Temat


Tytuł :
Nonlinear Method to Predict the Distribution of Structurally Diverse Compounds between Blood and Tissue.
Autorzy :
Wang S; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
Hu S; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
Zhang H; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China. Electronic address: .
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Źródło :
Journal of pharmaceutical sciences [J Pharm Sci] 2020 Dec; Vol. 109 (12), pp. 3697-3715. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Pharmacokinetics*
Tissue Distribution*
Anions ; Cations ; Humans
Czasopismo naukowe
Tytuł :
Sex and Gender Differences in Clinical Pharmacology: Implications for Transgender Medicine.
Autorzy :
Cirrincione LR; Department of Pharmacy, University of Washington, Seattle, Washington, USA.
Huang KJ; Department of Psychology, University of California - Los Angeles, Los Angeles, California, USA.
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Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Oct; Vol. 110 (4), pp. 897-908. Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Transgender Persons*
Androgens/*pharmacology
Cytochrome P-450 Enzyme System/*drug effects
Estrogens/*pharmacology
Glucuronosyltransferase/*drug effects
Androgens/therapeutic use ; Body Composition/drug effects ; Body Composition/physiology ; Cytochrome P-450 Enzyme System/metabolism ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions ; Estrogens/therapeutic use ; Female ; Glucuronosyltransferase/metabolism ; Humans ; Intestinal Absorption/drug effects ; Intestinal Absorption/physiology ; Male ; Pharmacology, Clinical ; Renal Elimination/drug effects ; Renal Elimination/physiology ; Sex Factors ; Testosterone/therapeutic use ; Tissue Distribution/drug effects ; Tissue Distribution/physiology
Czasopismo naukowe
Tytuł :
Scientific Accuracy Matters.
Autorzy :
Larson CP; From the Department of Anesthesia and Critical Care, Stanford University School of Medicine, Stanford, California; and the Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
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Źródło :
Anesthesiology [Anesthesiology] 2021 Oct 01; Vol. 135 (4), pp. 724-727.
Typ publikacji :
Classical Article; Journal Article; Portrait
MeSH Terms :
Anesthetics, Inhalation/*metabolism
Biomedical Research/*standards
Halothane/*metabolism
Anesthetics, Inhalation/chemistry ; Animals ; Cattle ; Halothane/chemistry ; Humans ; Solubility/drug effects ; Tissue Distribution/drug effects ; Tissue Distribution/physiology
Czasopismo naukowe
Tytuł :
Characterization of MRF genes and their tissue distributions and analysis of the effects of starvation and refeeding on the expression of these genes in Acipenser dabryanus muscle.
Autorzy :
Wu XY; Fishery Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China.
Lai JS; Fishery Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China.
Chen YY; Fishery Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China.
Liu Y; Fishery Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China.
Song MJ; Fishery Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China.
Li FY; Fishery Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China.
Shi QC; Key Laboratory of Sichuan Province for Fishes Conservation and Utilization in the Upper Reaches of the Yangtze River, Neijiang Normal University, Neijiang 64100, China.
Gong Q; Fishery Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 2021 Oct-Dec; Vol. 256, pp. 110648. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Feeding Behavior*
Gene Expression Regulation*
Starvation*
Fish Proteins/*metabolism
Muscle Proteins/*metabolism
Muscle, Skeletal/*metabolism
Myogenic Regulatory Factors/*metabolism
Animals ; Fish Proteins/genetics ; Fishes ; Muscle Proteins/genetics ; Myogenic Regulatory Factors/genetics ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Organ and tissue-specific distribution of selected polycyclic aromatic hydrocarbons (PAHs) in ApoE-KO mouse.
Autorzy :
Jin X; State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, No.5 Yiheyuan Street, Beijing, 100871, China.
Hua Q; State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.
Liu Y; State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.
Wu Z; National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, No. 29 Nanwei Street, Beijing, 100050, China.
Xu D; State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.
Ren Q; State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China.
Zhao W; National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, No. 29 Nanwei Street, Beijing, 100050, China.
Guo X; State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Oct 01; Vol. 286, pp. 117219. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Polycyclic Aromatic Hydrocarbons*/analysis
Animals ; Apolipoproteins E/genetics ; Benzo(a)pyrene/analysis ; Environmental Monitoring ; Gas Chromatography-Mass Spectrometry ; Mice ; Tissue Distribution
Czasopismo naukowe
Tytuł :
A population approach for the estimation of methylmercury ToxicoKinetics in red mullets.
Autorzy :
Pellicanò F; Laboratorio di Biomatematica, Istituto di Analisi dei Sistemi ed Informatica 'A. Ruberti' (IASI), Consiglio Nazionale delle Ricerche (CNR), Roma, Italy.
D'Orsi L; Laboratorio di Biomatematica, Istituto di Analisi dei Sistemi ed Informatica 'A. Ruberti' (IASI), Consiglio Nazionale delle Ricerche (CNR), Roma, Italy.
De Gaetano A; Laboratorio di Biomatematica, Istituto di Analisi dei Sistemi ed Informatica 'A. Ruberti' (IASI), Consiglio Nazionale delle Ricerche (CNR), Roma, Italy; Istituto per la Ricerca e l'Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche (CNR), Palermo, Italy.
Panunzi S; Laboratorio di Biomatematica, Istituto di Analisi dei Sistemi ed Informatica 'A. Ruberti' (IASI), Consiglio Nazionale delle Ricerche (CNR), Roma, Italy. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Oct 01; Vol. 428, pp. 115679. Date of Electronic Publication: 2021 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Methylmercury Compounds/*pharmacokinetics
Methylmercury Compounds/*toxicity
Smegmamorpha/*metabolism
Water Pollutants, Chemical/*pharmacokinetics
Water Pollutants, Chemical/*toxicity
Animals ; Tissue Distribution/drug effects ; Tissue Distribution/physiology ; Toxicokinetics
Czasopismo naukowe
Tytuł :
An UPLC - Q - Orbitrap method for pharmacokinetics and tissue distribution of four triterpenoids in rats after oral administration of Poria cocos ethanol extracts.
Autorzy :
Zhang J; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China. Electronic address: .
Guo H; Center for Biological Technology, Anhui Agricultural University, Hefei, 230036, China.
Yan F; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China.
Yuan S; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China.
Li S; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China.
Zhu P; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China.
Chen W; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei, 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, 230012, China.
Peng C; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei, 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, 230012, China. Electronic address: .
Peng D; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei, 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, 230012, China. Electronic address: .
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 Sep 05; Vol. 203, pp. 114237. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
Drugs, Chinese Herbal*/analysis
Triterpenes*/analysis
Wolfiporia*
Administration, Oral ; Animals ; China ; Chromatography, High Pressure Liquid ; Ethanol ; Rats ; Reproducibility of Results ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Pharmacokinetics, tissue distribution and plasma protein binding rate of palmatine following intragastric and intravenous administration in rats using liquid chromatography tandem mass spectrometry.
Autorzy :
Song Y; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wang K; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wei X; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wei T; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Xiao T; Department of Pharmaceutical Analysis, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China.
Wei M; Department of Pharmacology, School of Pharmacy, China Medical University, Puhe Road No. 77, Shenyang City, 110122, Liaoning Province, China. Electronic address: .
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2021 Sep 05; Vol. 203, pp. 114226. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Tandem Mass Spectrometry*
Administration, Intravenous ; Animals ; Berberine Alkaloids ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Protein Binding ; Rats ; Reproducibility of Results ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Pharmacokinetic and tissue distribution study of ZCY-15, a novel compound against Alzheimer's disease, in rats by liquid chromatography-tandem mass spectrometry.
Autorzy :
Lin C; Department of Pharmacy, The First Hospital of China Medical University, Nanjing Street No.155, Heping District, Shenyang City 110001, Liaoning, China; School of Pharmaceutical Science, China Medical University, Puhe Road No.77, Shenyang City 110122, Liaoning, China.
Zhang D; Department of Pharmacy, The First Hospital of China Medical University, Nanjing Street No.155, Heping District, Shenyang City 110001, Liaoning, China.
Sun S; Department of Pharmacy, The First Hospital of China Medical University, Nanjing Street No.155, Heping District, Shenyang City 110001, Liaoning, China.
Shi Y; Department of Pharmacy, The First Hospital of China Medical University, Nanjing Street No.155, Heping District, Shenyang City 110001, Liaoning, China.
Yan C; Department of Pharmacy, The First Hospital of China Medical University, Nanjing Street No.155, Heping District, Shenyang City 110001, Liaoning, China.
Lin J; Department of Pharmacy, The First Hospital of China Medical University, Nanjing Street No.155, Heping District, Shenyang City 110001, Liaoning, China. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 Sep 01; Vol. 164, pp. 105917. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/drug therapy
Tandem Mass Spectrometry*
Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Female ; Male ; Rats ; Reproducibility of Results ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Tissue distribution and developmental changes of PTEN in the immune organs of chicken and effect of IBDV infection on it.
Autorzy :
Yu Y; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
Li L; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
Sun R; Zhengzhou Railway vocational & Technical College, Zhengzhou, 450052, Henan, China.
Xu Z; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
Wang Q; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
Ou C; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
Zhang Y; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
Gao P; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China.
Ma J; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, 453003, Henan, China. Electronic address: .
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Źródło :
Poultry science [Poult Sci] 2021 Sep; Vol. 100 (9), pp. 101356. Date of Electronic Publication: 2021 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Birnaviridae Infections*/veterinary
Infectious bursal disease virus*
Poultry Diseases*/genetics
Animals ; Bursa of Fabricius ; Chickens ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Role of the Abcg2 transporter in plasma levels and tissue accumulation of the anti-inflammatory tolfenamic acid in mice.
Autorzy :
Blanco-Paniagua E; Department of Biomedical Sciences-Physiology, Veterinary Faculty, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, 24071, Campus de Vegazana, León, Spain.
García-Lino AM; Department of Biomedical Sciences-Physiology, Veterinary Faculty, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, 24071, Campus de Vegazana, León, Spain.
García-Mateos D; Department of Biomedical Sciences-Physiology, Veterinary Faculty, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, 24071, Campus de Vegazana, León, Spain.
Álvarez AI; Department of Biomedical Sciences-Physiology, Veterinary Faculty, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, 24071, Campus de Vegazana, León, Spain.
Merino G; Department of Biomedical Sciences-Physiology, Veterinary Faculty, Instituto de Desarrollo Ganadero y Sanidad Animal (INDEGSAL), Universidad de León, 24071, Campus de Vegazana, León, Spain. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109537. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Bacterial Vaccines/*blood
Bacterial Vaccines/*pharmacokinetics
ortho-Aminobenzoates/*blood
ortho-Aminobenzoates/*pharmacokinetics
Animals ; Bacterial Vaccines/pharmacology ; Biological Transport ; Mice ; Tissue Distribution ; ortho-Aminobenzoates/pharmacology
Czasopismo naukowe
Tytuł :
Pharmacokinetics and tissue distribution study of hupehenenine in rats: A novel isosteroid alkaloid isolated from Bulbus Hupehensis Fritillariae.
Autorzy :
Zhang Q; West China School of Pharmacy, Sichuan University, Chengdu, China.
Li D; West China School of Pharmacy, Sichuan University, Chengdu, China.
Ma B; West China School of Pharmacy, Sichuan University, Chengdu, China.
Wang X; West China Hospital, Sichuan University, Chengdu, China.
Yang J; West China School of Pharmacy, Sichuan University, Chengdu, China.
Chen D; West China School of Pharmacy, Sichuan University, Chengdu, China.
Ye L; West China School of Pharmacy, Sichuan University, Chengdu, China.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2021 Aug; Vol. 35 (8), pp. e5122. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids*/analysis
Alkaloids*/pharmacokinetics
Drugs, Chinese Herbal*/administration & dosage
Drugs, Chinese Herbal*/pharmacokinetics
Fritillaria/*chemistry
Plant Roots/*chemistry
Animals ; Cell Line, Tumor ; Chromatography, High Pressure Liquid ; Female ; Humans ; Male ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Toxicity of pemetrexed during renal impairment explained-Implications for safe treatment.
Autorzy :
Boosman RJ; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dorlo TPC; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute, Amsterdam, The Netherlands.
de Rouw N; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Pharmacy, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
Burgers JA; Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dingemans AC; Department of Pulmonary Diseases, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.; Department of Pulmonology, Erasmus MC, Rotterdam, The Netherlands.
van den Heuvel MM; Department of Pulmonology, Radboud university medical center, Nijmegen, The Netherlands.
Hendriks LEL; Department of Pulmonary Diseases, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Biesma B; Department of Pulmonary Diseases, Jeroen Bosch Hospital, 's Hertogenbosch, The Netherlands.
Aerts JGJV; Department of Pulmonology, Erasmus MC, Rotterdam, The Netherlands.
Croes S; Department of Clinical Pharmacy & Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Mathijssen RHJ; Department of Medical Oncology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands.
Huitema ADR; Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Clinical Pharmacy, Utrecht University Medical Center, Utrecht University, Utrecht, The Netherlands.; Department of Pharmacology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Ter Heine R; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Oct 15; Vol. 149 (8), pp. 1576-1584. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*drug therapy
Folic Acid Antagonists/*adverse effects
Kidney Failure, Chronic/*chemically induced
Lung Neoplasms/*drug therapy
Neutropenia/*chemically induced
Pemetrexed/*adverse effects
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/pathology ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Dietary Supplements ; Dose-Response Relationship, Drug ; Female ; Folic Acid Antagonists/administration & dosage ; Folic Acid Antagonists/pharmacokinetics ; Follow-Up Studies ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/prevention & control ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neutropenia/epidemiology ; Neutropenia/prevention & control ; Pemetrexed/administration & dosage ; Pemetrexed/pharmacokinetics ; Prognosis ; Tissue Distribution
Czasopismo naukowe
Tytuł :
First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier.
Autorzy :
Servent D; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France. Electronic address: .
Malgorn C; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Bernes M; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Gil S; Université de Paris, UMR-S1139, Faculté de Pharmacie de Paris, France.
Simasotchi C; Université de Paris, UMR-S1139, Faculté de Pharmacie de Paris, France.
Hérard AS; Université Paris-Saclay, UMR9199, CNRS, CEA, MIRCen, Fontenay-aux-Roses, France.
Delzescaux T; Université Paris-Saclay, UMR9199, CNRS, CEA, MIRCen, Fontenay-aux-Roses, France.
Thai R; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Barbe P; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Keck M; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Beau F; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Zakarian A; University of California, Santa Barbara, Department of Chemistry and Biochemistry, CA 93106-9510, USA.
Dive V; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France.
Molgó J; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SIMoS, ERL CNRS 9004, F-91191 Gif sur Yvette, France. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Oct 10; Vol. 790, pp. 148125. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Placenta*
Shellfish*
Animals ; Brain ; Female ; Humans ; Pregnancy ; Rats ; Seafood ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Synthesis and preclinical evaluation of an Al F radiofluorinated bivalent PSMA ligand.
Autorzy :
Huang Y; Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong Province, 510515, China; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
Li H; Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong Province, 510515, China.
Ye S; Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong Province, 510515, China.
Tang G; Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong Province, 510515, China.
Liang Y; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Hu K; Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong Province, 510515, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113502. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Surface/*analysis
Glutamate Carboxypeptidase II/*analysis
Prostatic Neoplasms/*diagnostic imaging
Radiopharmaceuticals/*chemistry
Animals ; Fluorine Radioisotopes ; Halogenation ; Humans ; Ligands ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Neoplasms, Experimental/diagnostic imaging ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Phase I clinical trial of HC-1119: A deuterated form of enzalutamide.
Autorzy :
Li X; Institute of Clinical Pharmacology, GCP center, West China Hospital, Sichuan University, Chengdu, China.; State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
Cheng K; Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China.
Li X; Hinova Pharmaceuticals Inc., Chengdu, China.
Zhou Y; Department of Biotherapy, Cancer Center of West China Hospital, Sichuan University, Chengdu, China.
Liu J; Department of Biotherapy, Cancer Center of West China Hospital, Sichuan University, Chengdu, China.
Zeng H; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Chen Y; Hinova Pharmaceuticals Inc., Chengdu, China.
Liu X; Haisco Pharmaceuticals Inc., Shanghai, China.
Zhang Y; Haisco Pharmaceuticals Inc., Shanghai, China.
Wang Y; State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.; Institute of Clinical Pharmacology, GCP center, Department of Thoracic, Chengdu, China.
Bi F; Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, China.
Zheng L; Institute of Clinical Pharmacology, GCP center, West China Hospital, Sichuan University, Chengdu, China.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Oct 01; Vol. 149 (7), pp. 1473-1482. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*therapeutic use
Benzamides/*therapeutic use
Nitriles/*therapeutic use
Phenylthiohydantoin/*therapeutic use
Prostatic Neoplasms/*drug therapy
Adenocarcinoma/secondary ; Aged ; Aged, 80 and over ; Antineoplastic Agents/pharmacokinetics ; Benzamides/pharmacokinetics ; Follow-Up Studies ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Nitriles/pharmacokinetics ; Phenylthiohydantoin/pharmacokinetics ; Prognosis ; Prostatic Neoplasms/pathology ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Identification of a peptide binding to cancer antigen Kita-kyushu lung cancer antigen 1 from a phage-display library.
Autorzy :
Yu X; The Comprehensive Cancer Center, China Pharmaceutical University Nanjing Drum Tower Hospital, Nanjing, China.
Yan J; The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Chen X; The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Wei J; The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Yu L; The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Liu F; Department of Pathology of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Li L; Department of Pathology of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Liu B; The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Oct; Vol. 112 (10), pp. 4335-4345. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji :
Journal Article
MeSH Terms :
Peptide Library*
Antigens, Neoplasm/*metabolism
Bacteriophages/*chemistry
Peptides, Cyclic/*metabolism
Stomach Neoplasms/*metabolism
Animals ; Bacteriophages/genetics ; Cell Line, Tumor ; Epitopes/metabolism ; Humans ; Mice ; Molecular Targeted Therapy ; Organ Specificity ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/isolation & purification ; Sequence Analysis, DNA/methods ; Stomach Neoplasms/therapy ; Tissue Distribution
Czasopismo naukowe
Tytuł :
The in vivo disposition of subcutaneous injected C-AKB-9778), a sulphamic acid phosphatase inhibitor, in nonclinical species and human.
Autorzy :
Soldo BL; Aerpio Pharmaceuticals, Cincinnati, OH, USA.
Camilleri P; Bio-Chemical Solutions, Stevenage, UK.
Buch A; Aerpio Pharmaceuticals, Cincinnati, OH, USA.
Janusz J; Aerpio Pharmaceuticals, Cincinnati, OH, USA.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Oct; Vol. 51 (10), pp. 1132-1145. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Acid Phosphatase*
Aniline Compounds ; Animals ; Dogs ; Feces ; Humans ; Kinetics ; Rats ; Sulfonic Acids ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Adipose Tissue Distribution Predicts Prognosis of Cirrhotic Patients Undergoing Hepatectomy for Hepatocellular Carcinoma.
Autorzy :
Okubo S; Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological surgery, Toranomon Hospital, Minatoku, Tokyo, Japan.
Shindoh J; Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological surgery, Toranomon Hospital, Minatoku, Tokyo, Japan. .; Okinaka Memorial Institute for Medical Disease, Tokyo, Japan. .
Kobayashi Y; Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological surgery, Toranomon Hospital, Minatoku, Tokyo, Japan.
Umino R; Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological surgery, Toranomon Hospital, Minatoku, Tokyo, Japan.
Akabane M; Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological surgery, Toranomon Hospital, Minatoku, Tokyo, Japan.
Kojima K; Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological surgery, Toranomon Hospital, Minatoku, Tokyo, Japan.
Hashimoto M; Hepato-Biliary-Pancreatic Surgery Division, Department of Gastroenterological surgery, Toranomon Hospital, Minatoku, Tokyo, Japan.
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Źródło :
Annals of surgical oncology [Ann Surg Oncol] 2021 Oct; Vol. 28 (11), pp. 6738-6746. Date of Electronic Publication: 2021 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/surgery
Liver Neoplasms*/surgery
Hepatectomy ; Humans ; Liver Cirrhosis/complications ; Neoplasm Recurrence, Local/surgery ; Prognosis ; Retrospective Studies ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Photodiagnosis and photodynamic effects of bacteriochlorin-naphthalimide conjugates on tumor cells and mouse model.
Autorzy :
Morozova NB; P.A. Hertsen Moscow Oncology Research Institute - Branch of the National Medical Research Center of Radiology, 125284, 2-nd Botkinsky proezd 3, Moscow, Russia.
Pavlova MA; A.N. Nesmeyanov Institute of Organoelement Compounds of RussianAcademy of Sciences (INEOS RAS), 119991, Vavilova str. 28, Moscow, Russia. Electronic address: .
Plyutinskaya AD; P.A. Hertsen Moscow Oncology Research Institute - Branch of the National Medical Research Center of Radiology, 125284, 2-nd Botkinsky proezd 3, Moscow, Russia.
Pankratov AA; P.A. Hertsen Moscow Oncology Research Institute - Branch of the National Medical Research Center of Radiology, 125284, 2-nd Botkinsky proezd 3, Moscow, Russia.
Efendiev KT; National Research Nuclear University MEPhI, 115409, Kashirskoe Shosse 31, Moscow, Russia.
Semkina AS; Pirogov Russian National Research Medical University, 117997, Ostrovitianov str. 1, Moscow, Russia.
Pritmov DA; MIREA - Russian Technological University, 119454 Moscow, pr.Vernadskogo, 86, Russia.
Mironov AF; MIREA - Russian Technological University, 119454 Moscow, pr.Vernadskogo, 86, Russia.
Panchenko PA; A.N. Nesmeyanov Institute of Organoelement Compounds of RussianAcademy of Sciences (INEOS RAS), 119991, Vavilova str. 28, Moscow, Russia.
Fedorova OA; A.N. Nesmeyanov Institute of Organoelement Compounds of RussianAcademy of Sciences (INEOS RAS), 119991, Vavilova str. 28, Moscow, Russia.
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2021 Oct; Vol. 223, pp. 112294. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Naphthalimides/*chemistry
Neoplasms/*drug therapy
Photosensitizing Agents/*therapeutic use
Porphyrins/*chemistry
Animals ; Cell Line, Tumor ; Lasers ; Mice ; Naphthalimides/metabolism ; Neoplasms/diagnosis ; Neoplasms/pathology ; Optical Imaging ; Photochemotherapy/methods ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/metabolism ; Photosensitizing Agents/pharmacology ; Porphyrins/metabolism ; Tissue Distribution ; Transplantation, Homologous
Czasopismo naukowe

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