Autor: "Titz, Bjoern" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies.
Autorzy :: Lavrynenko O; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland. Electronic address: .
Titz B; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Dijon S; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Santos DD; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Nury C; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Schneider T; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Guedj E; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Szostak J; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Kondylis A; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Phillips B; Philip Morris International Research Laboratories Pte. Ltd., Science Park II, 117406, Singapore.
Ekroos K; Lipidomics Consulting Ltd., Irisviksvägen 31D, 02230 Esbo, Finland.
Martin F; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Peitsch MC; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Hoeng J; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Ivanov NV; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.; Pokaż więcej
Źródło :: Life sciences [Life Sci] 2020 Dec 15; Vol. 263, pp. 118753. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :: Comparative Study; Journal Article; Validation Study
MeSH Terms :: Apolipoproteins E/*genetics
Ceramides/*metabolism
E-Cigarette Vapor/*adverse effects
Lung/*metabolism
Smoke/*adverse effects
Aerosols/adverse effects ; Animals ; Ceramides/analysis ; Chromatography, Liquid/methods ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proteomics ; Risk Factors ; Tandem Mass Spectrometry/methods ; Time Factors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Structural, functional, and molecular impact on the cardiovascular system in ApoE mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.
Autorzy :: Szostak J; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Titz B; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: Bjorn.Titz@pmi.com.
Schlage WK; Biology Consultant, Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany. Electronic address: .
Guedj E; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Sewer A; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Phillips B; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. Electronic address: .
Leroy P; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Buettner A; Histovia GmbH, Schöne Aussicht 5, 51491, Overath, Germany. Electronic address: .
Neau L; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Trivedi K; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Martin F; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Ivanov NV; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Vanscheeuwijck P; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Peitsch MC; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .
Hoeng J; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland. Electronic address: .; Pokaż więcej
Źródło :: Chemico-biological interactions [Chem Biol Interact] 2020 Jan 05; Vol. 315, pp. 108887. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :: Journal Article
MeSH Terms :: Aerosols/*adverse effects
Apolipoproteins E/*metabolism
Carbon/*adverse effects
Cardiovascular System/*drug effects
Smoke/*adverse effects
Tobacco/*adverse effects
Tobacco Products/*adverse effects
Animals ; Aorta, Thoracic/drug effects ; Atherosclerosis/metabolism ; Cardiovascular System/metabolism ; Female ; Heating/adverse effects ; Inhalation Exposure/adverse effects ; Lung/drug effects ; Lung/metabolism ; Mice ; Smoking/adverse effects ; Transcriptome/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke.
Autorzy :: Kogel U; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Titz B; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Schlage WK; Biology consultant, Max-Baermann-Str. 21, 51429 Bergisch Gladbach, Germany.
Nury C; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Martin F; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Oviedo A; Philip Morris International Research Laboratories, 50 Science Park Road, Singapore, Singapore(2).
Lebrun S; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Elamin A; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Guedj E; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Trivedi K; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Ivanov NV; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Vanscheeuwijck P; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Peitsch MC; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2).
Hoeng J; Philip Morris International Research and Development, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland(2). Electronic address: .; Pokaż więcej
Źródło :: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2016 Nov 30; Vol. 81 Suppl 2, pp. S123-S138. Date of Electronic Publication: 2016 Nov 04.
Typ publikacji :: Comparative Study; Journal Article
MeSH Terms :: Harm Reduction*
Hot Temperature*
Tobacco Industry*
Electronic Nicotine Delivery Systems/*adverse effects
Menthol/*toxicity
Smoke/*adverse effects
Smoking/*adverse effects
Tobacco Products/*toxicity
Toxicity Tests/*methods
Aerosols ; Animals ; Consumer Product Safety ; Dose-Response Relationship, Drug ; Equipment Design ; Female ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Genetic Markers ; Humans ; Inhalation Exposure/adverse effects ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Male ; Menthol/analysis ; Nasal Mucosa/drug effects ; Nasal Mucosa/metabolism ; Nasal Mucosa/pathology ; Pneumonia/chemically induced ; Pneumonia/genetics ; Pneumonia/pathology ; Pneumonia/prevention & control ; Proteomics ; Rats, Sprague-Dawley ; Risk Assessment ; Smoke/analysis ; Smoking/genetics ; Systems Biology ; Time Factors ; Tobacco Products/analysis ; Toxicogenetics ; Transcriptome/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.
Autorzy :: Oviedo A; Philip Morris International Research Laboratories Pte Ltd, 50 Science Park Road #02-07, The Kendall, Science Park II, Singapore 117406, Singapore(2).
Lebrun S; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Kogel U; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Ho J; Philip Morris International Research Laboratories Pte Ltd, 50 Science Park Road #02-07, The Kendall, Science Park II, Singapore 117406, Singapore(2).
Tan WT; Philip Morris International Research Laboratories Pte Ltd, 50 Science Park Road #02-07, The Kendall, Science Park II, Singapore 117406, Singapore(2).
Titz B; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Leroy P; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Vuillaume G; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Bera M; Former employee of Philip Morris International R&D, Switzerland.
Martin F; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Rodrigo G; Former employee of Philip Morris International R&D, Switzerland.
Esposito M; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Dempsey R; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Ivanov NV; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Hoeng J; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Peitsch MC; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2).
Vanscheeuwijck P; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland(2). Electronic address: .; Pokaż więcej
Źródło :: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2016 Nov 30; Vol. 81 Suppl 2, pp. S93-S122. Date of Electronic Publication: 2016 Nov 03.
Typ publikacji :: Comparative Study; Journal Article
MeSH Terms :: Harm Reduction*
Hot Temperature*
Tobacco Industry*
Electronic Nicotine Delivery Systems/*adverse effects
Menthol/*toxicity
Smoke/*adverse effects
Smoking/*adverse effects
Tobacco Products/*toxicity
Toxicity Tests/*methods
Aerosols ; Animals ; Biomarkers/blood ; Biomarkers/urine ; Computational Biology ; Consumer Product Safety ; Dose-Response Relationship, Drug ; Equipment Design ; Female ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Genetic Markers ; Genomics ; Humans ; Inhalation Exposure/adverse effects ; Lung/drug effects ; Lung/metabolism ; Male ; Menthol/analysis ; Nasal Mucosa/drug effects ; Nasal Mucosa/metabolism ; Rats, Sprague-Dawley ; Risk Assessment ; Smoke/analysis ; Smoking/blood ; Smoking/genetics ; Smoking/urine ; Time Factors ; Tobacco Products/analysis ; Toxicogenetics ; Transcriptome/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice.
Autorzy :: Elamin A; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Titz B; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Dijon S; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Merg C; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Geertz M; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland; Bayer Technology Services GmbH, 51368 Leverkusen, Germany.
Schneider T; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Martin F; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Schlage WK; Biology Consultant, Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany.
Frentzel S; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Talamo F; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Phillips B; Philip Morris International Research Laboratories (part of Philip Morris International group of companies), 50 Science Park Road, 117406, Singapore.
Veljkovic E; Philip Morris International Research Laboratories (part of Philip Morris International group of companies), 50 Science Park Road, 117406, Singapore.
Ivanov NV; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Vanscheeuwijck P; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Peitsch MC; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Hoeng J; Philip Morris Research and Development, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland. Electronic address: .; Pokaż więcej
Źródło :: Journal of proteomics [J Proteomics] 2016 Aug 11; Vol. 145, pp. 237-245. Date of Electronic Publication: 2016 Jun 05.
Typ publikacji :: Comparative Study; Journal Article
MeSH Terms :: Aerosols/*adverse effects
Lung/*chemistry
Proteome/*drug effects
Proteomics/*methods
Smoke/*adverse effects
Actins/drug effects ; Animals ; Chromatography, Liquid ; Cytoskeleton/drug effects ; Electrophoresis, Gel, Two-Dimensional ; Inhalation Exposure/adverse effects ; Lung/pathology ; Mice ; Mice, Inbred C57BL ; Proteasome Endopeptidase Complex/drug effects ; Proteome/analysis ; Tandem Mass Spectrometry ; Tobacco Products
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects.
Autorzy :: Titz B; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland. Electronic address: bjorn.titz@pmi.com.
Sewer A; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Schneider T; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Elamin A; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Martin F; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Dijon S; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Luettich K; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Guedj E; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Vuillaume G; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Ivanov NV; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Peck MJ; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Chaudhary NI; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Hoeng J; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
Peitsch MC; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.; Pokaż więcej
Źródło :: Journal of proteomics [J Proteomics] 2015 Oct 14; Vol. 128, pp. 306-20. Date of Electronic Publication: 2015 Aug 22.
Typ publikacji :: Journal Article; Randomized Controlled Trial
MeSH Terms :: Proteome/*metabolism
Pulmonary Disease, Chronic Obstructive/*metabolism
Smoking/*epidemiology
Smoking/*metabolism
Sputum/*metabolism
Transcription Factors/*metabolism
Adult ; Aged ; Biomarkers/blood ; Biomarkers/metabolism ; Causality ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Smoking Cessation/statistics & numerical data ; Smoking Prevention ; Transcriptome ; United Kingdom/epidemiology
: Czasopismo naukowe

Szczegóły

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