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Tytuł :
Application of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using an e-cigarette device with MESH™ technology
Autorzy :
Iskandar, Anita R.
Zanetti, Filippo
Marescotti, Diego
Titz, Bjorn
Sewer, Alain
Kondylis, Athanasios
Leroy, Patrice
Belcastro, Vincenzo
Torres, Laura Ortega
Acali, Stefano
Majeed, Shoaib
Steiner, Sandro
Trivedi, Keyur
Guedj, Emmanuel
Merg, Celine
Schneider, Thomas
Frentzel, Stefan
Martin, Florian
Ivanov, Nikolai V.
Peitsch, Manuel C.
Hoeng, Julia
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Źródło :
Archives of Toxicology. 93(11):3229-3247
Czasopismo naukowe
Tytuł :
Comparative biological impacts of an aerosol from carbon-heated tobacco and smoke from cigarettes on human respiratory epithelial cultures: A systems toxicology assessment
Autorzy :
Iskandar, Anita R.
Mathis, Carole
Titz, Bjorn
Kondylis, Athanasios
Schneider, Thomas
Vuillaume, Grégory
Sewer, Alain
Guedj, Emmanuel
Trivedi, Keyur
Elamin, Ashraf
Frentzel, Stefan
Ivanov, Nikolai V.
Peitsch, Manuel C.
Hoeng, Julia
Pokaż więcej
Źródło :
In Food and Chemical Toxicology May 2018 115:109-126
Czasopismo naukowe
Tytuł :
Exposure to cigarette smoke and aerosol from the potential reduced risk product THS2.2 on A/J mice in life-time inhalation study
Autorzy :
Veljkovic, Emilija
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Źródło :
In Abstracts of the 53rd Congress of the European Societies of Toxicology (EUROTOX)Bratislava, Slovakia, 10th-13th September, 2017, Toxicology Letters 20 October 2017 280 Supplement 1:S143-S143
Czasopismo naukowe
Tytuł :
Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Autorzy :
Chen Z
Shojaee S
Buchner M
Geng H
Lee JW
Klemm L
Titz B
Graeber TG
Park E
Tan YX
Satterthwaite A
Paietta E
Hunger SP
Willman CL
Melnick A
Loh ML
Jung JU
Coligan JE
Bolland S
Mak TW
Limnander A
Jumaa H
Reth M
Weiss A
Lowell CA
Müschen M
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Źródło :
Nature [Nature] 2016 Jun 02; Vol. 534 (7605), pp. 138. Date of Electronic Publication: 2016 Mar 09.
Typ publikacji :
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł :
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Autorzy :
Chen Z; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Shojaee S; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Buchner M; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Geng H; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Lee JW; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Klemm L; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Titz B; Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA.
Graeber TG; Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA.
Park E; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Tan YX; Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA.
Satterthwaite A; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Paietta E; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10466, USA.
Hunger SP; Division of Pediatric Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Philadelphia 19104, USA.
Willman CL; University of New Mexico Cancer Center, Albuquerque, New Mexico 87102, USA.
Melnick A; Departments of Medicine and Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA.
Loh ML; Pediatric Hematology-Oncology, University of California, San Francisco, California 94143, USA.
Jung JU; Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA.
Coligan JE; Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
Bolland S; Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
Mak TW; The Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, Ontario M5G 2M9, Canada.
Limnander A; Department of Anatomy, University of California, San Francisco, California 94143, USA.
Jumaa H; Institute of Immunology, University Clinics Ulm, 89081 Ulm, Germany.
Reth M; BIOSS Centre for Biological Signalling Studies and Faculty of Biology, Albert-Ludwigs-Universität Freiburg, and MPI of Immunbiologie and Epigenetics, 79104 Freiburg, Germany.
Weiss A; Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA.
Lowell CA; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
Müschen M; Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
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Źródło :
Nature [Nature] 2015 May 21; Vol. 521 (7552), pp. 357-61. Date of Electronic Publication: 2015 Mar 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*/drug effects
B-Lymphocytes/*metabolism
B-Lymphocytes/*pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
Amino Acid Motifs/genetics ; Animals ; Antigens, CD/metabolism ; B-Lymphocytes/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Disease Models, Animal ; Drug Resistance, Neoplasm/drug effects ; Enzyme Activation/drug effects ; Female ; Fusion Proteins, bcr-abl/genetics ; Gene Deletion ; Humans ; Inositol Polyphosphate 5-Phosphatases ; Intracellular Signaling Peptides and Proteins/agonists ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases ; Phosphoric Monoester Hydrolases/antagonists & inhibitors ; Phosphoric Monoester Hydrolases/metabolism ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cells, B-Lymphoid/drug effects ; Precursor Cells, B-Lymphoid/metabolism ; Precursor Cells, B-Lymphoid/pathology ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/deficiency ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism ; Protein-Tyrosine Kinases/metabolism ; Receptors, Antigen, B-Cell/deficiency ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Syk Kinase ; Tyrosine/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.
Autorzy :
Ting PY; Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
Damoiseaux R; California NanoSystems Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Titz B; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California at Los Angeles Metabolomics and Proteomics Center, California NanoSystems Institute and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, United States of America.
Bradley KA; Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, and California NanoSystems Institute, University of California Los Angeles, Los Angeles, California, United States of America.
Graeber TG; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California at Los Angeles Metabolomics and Proteomics Center, California NanoSystems Institute and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, United States of America.
Fernández-Vega V; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
Bannister TD; The Scripps Research Institute-FL, Department of Chemistry, Translational Research Institute, Jupiter, Florida, United States of America.
Chase P; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
Nair R; The Scripps Research Institute-FL, Department of Chemistry, Translational Research Institute, Jupiter, Florida, United States of America.
Scampavia L; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
Hodder P; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
Spicer TP; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
Colicelli J; Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
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Źródło :
PloS one [PLoS One] 2015 Mar 26; Vol. 10 (3), pp. e0121833. Date of Electronic Publication: 2015 Mar 26 (Print Publication: 2015).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Intracellular Signaling Peptides and Proteins/*metabolism
Proto-Oncogene Proteins c-abl/*metabolism
Signal Transduction/*drug effects
Small Molecule Libraries/*pharmacology
Biflavonoids/pharmacology ; Catechin/analogs & derivatives ; Catechin/pharmacology ; Fluorescence Resonance Energy Transfer ; Fusion Proteins, bcr-abl/metabolism ; High-Throughput Screening Assays ; Humans ; K562 Cells ; Mitogen-Activated Protein Kinase 1/metabolism ; Phosphorylation/drug effects ; Protein Binding/drug effects ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-abl/antagonists & inhibitors ; Reproducibility of Results ; Small Molecule Libraries/chemistry ; Time Factors
Czasopismo naukowe
Tytuł :
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.
Autorzy :
Ploper D; Howard Hughes Medical Institute and Department of Biological Chemistry.
Taelman VF; Howard Hughes Medical Institute and Department of Biological Chemistry.
Robert L; Department of Medicine, Division of Hematology-Oncology.
Perez BS; Howard Hughes Medical Institute and Department of Biological Chemistry.
Titz B; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, and.
Chen HW; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Graeber TG; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
von Euw E; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Ribas A; Department of Medicine, Division of Hematology-Oncology, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
De Robertis EM; Howard Hughes Medical Institute and Department of Biological Chemistry, .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Feb 03; Vol. 112 (5), pp. E420-9. Date of Electronic Publication: 2015 Jan 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endosomes/*physiology
Lysosomes/*physiology
Microphthalmia-Associated Transcription Factor/*physiology
Signal Transduction/*physiology
Wnt Proteins/*metabolism
Cell Line, Tumor ; Glycogen Synthase Kinase 3/metabolism ; HEK293 Cells ; Humans ; Phosphorylation
Czasopismo naukowe
Tytuł :
Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors.
Autorzy :
Anderson JL; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California. Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles, Los Angeles, California.
Titz B; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Akiyama R; Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles, Los Angeles, California.
Komisopoulou E; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Park A; Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles, Los Angeles, California.
Tap WD; Sarcoma Medical Oncology Service, Division of Solid Tumors, Department of Medicine, Memorial Sloan Kettering Cancer Center and Department of Medicine, Weill Cornell Medical College, New York, New York.
Graeber TG; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California. UCLA Metabolomics Center, University of California, Los Angeles, Los Angeles, California.
Denny CT; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California. Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California. .
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Źródło :
Molecular cancer research : MCR [Mol Cancer Res] 2014 Dec; Vol. 12 (12), pp. 1740-54. Date of Electronic Publication: 2014 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Neoplasms/*metabolism
Interleukin-6/*metabolism
Oncogene Proteins, Fusion/*genetics
Proteomics/*methods
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
STAT3 Transcription Factor/*metabolism
Sarcoma, Ewing/*metabolism
Apoptosis ; Cell Line, Tumor ; Gene Knockdown Techniques ; Humans ; Paracrine Communication ; Phosphorylation
Czasopismo naukowe
Tytuł :
Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
Autorzy :
Drake JM; Department of Microbiology, Immunology, and Molecular Genetics, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, Division of Hematology and Oncology, Department of Medicine, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Institute for Molecular Medicine, California NanoSystems Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Graham NA
Lee JK
Stoyanova T
Faltermeier CM
Sud S
Titz B
Huang J
Pienta KJ
Graeber TG
Witte ON
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Dec 03; Vol. 110 (49), pp. E4762-9. Date of Electronic Publication: 2013 Nov 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Discovery/*methods
Neoplasm Metastasis/*drug therapy
Phosphoproteins/*metabolism
Precision Medicine/*methods
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Prostatic Neoplasms, Castration-Resistant/*enzymology
Protein-Tyrosine Kinases/*metabolism
Blotting, Western ; Cell Line, Tumor ; Enzyme Activation/drug effects ; ErbB Receptors/metabolism ; Humans ; Male ; Mass Spectrometry ; Phosphorylation ; Phosphotyrosine/metabolism ; Principal Component Analysis
Czasopismo naukowe
Tytuł :
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.
Autorzy :
Swaminathan S; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
Huang C
Geng H
Chen Z
Harvey R
Kang H
Ng C
Titz B
Hurtz C
Sadiyah MF
Nowak D
Thoennissen GB
Rand V
Graeber TG
Koeffler HP
Carroll WL
Willman CL
Hall AG
Igarashi K
Melnick A
Müschen M
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Źródło :
Nature medicine [Nat Med] 2013 Aug; Vol. 19 (8), pp. 1014-22. Date of Electronic Publication: 2013 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic-Leucine Zipper Transcription Factors/*metabolism
Pre-B Cell Receptors/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Cell Death ; Cell Differentiation/genetics ; Cell Survival/genetics ; Cell Transformation, Neoplastic/pathology ; DNA-Binding Proteins/metabolism ; Gene Deletion ; Gene Expression Regulation, Leukemic ; Green Fluorescent Proteins/metabolism ; Immunoglobulin mu-Chains/metabolism ; Mice ; Molecular Sequence Data ; PAX5 Transcription Factor/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cells, B-Lymphoid/metabolism ; Precursor Cells, B-Lymphoid/pathology ; Proto-Oncogene Proteins c-bcl-6 ; Proto-Oncogene Proteins c-myc/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; STAT5 Transcription Factor/metabolism ; Treatment Outcome ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
RsfA (YbeB) proteins are conserved ribosomal silencing factors.
Autorzy :
Häuser R; Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Pech M
Kijek J
Yamamoto H
Titz B
Naeve F
Tovchigrechko A
Yamamoto K
Szaflarski W
Takeuchi N
Stellberger T
Diefenbacher ME
Nierhaus KH
Uetz P
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Źródło :
PLoS genetics [PLoS Genet] 2012; Vol. 8 (7), pp. e1002815. Date of Electronic Publication: 2012 Jul 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Bacteria*/genetics
Bacteria*/growth & development
Bacteria*/metabolism
Eukaryota*/genetics
Eukaryota*/growth & development
Eukaryota*/metabolism
Ribosomal Proteins/*chemistry
Ribosome Subunits, Large/*chemistry
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites ; Conserved Sequence ; HeLa Cells ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Molecular Sequence Data ; Phylogeny ; Protein Binding ; Protein Biosynthesis/genetics ; Ribosomal Proteins/metabolism ; Ribosome Subunits, Large/metabolism ; Sequence Homology, Amino Acid ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.
Autorzy :
Rubbi L; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Titz B; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Brown L; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Galvan E; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Komisopoulou E; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Chen SS; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Low T; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Tahmasian M; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.
Skaggs B; David Geffen School of Medicine, Division of Rheumatology, University of California, Los Angeles CA 90095, USA.
Müschen M; Department of Laboratory Medicine, University of California, San Francisco CA 94143, USA.
Pellegrini M; Institute for Genomics and Proteomics; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles CA 90095, USA.; California NanoSystems Institute, University of California, Los Angeles CA 90095, USA.
Graeber TG; Crump Institute for Molecular Imaging; Institute for Molecular Medicine; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, David Geffen School of Medicine, Department of Molecular & Medical Pharmacology, University of California, Los Angeles CA 90095, USA.; California NanoSystems Institute, University of California, Los Angeles CA 90095, USA.
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Źródło :
Science signaling [Sci Signal] 2011 Mar 29; Vol. 4 (166), pp. ra18. Date of Electronic Publication: 2011 Mar 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Proteomics*
Signal Transduction*
Fusion Proteins, bcr-abl/*metabolism
Leukemia/*enzymology
Protein-Tyrosine Kinases/*metabolism
src-Family Kinases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; CSK Tyrosine-Protein Kinase ; Cell Line, Transformed ; Cell Line, Tumor ; Fusion Proteins, bcr-abl/genetics ; Humans ; Leukemia/drug therapy ; Leukemia/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phosphorylation ; Protein Tyrosine Phosphatases, Non-Receptor/genetics ; Protein Tyrosine Phosphatases, Non-Receptor/metabolism ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; src-Family Kinases/antagonists & inhibitors ; src-Family Kinases/genetics
Czasopismo naukowe
Tytuł :
Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1.
Autorzy :
Sabri M; Département de Biochimie, de Microbiologie et Bio-Informatiques, Faculté des Sciences et de Génie, Groupe de Recherche en Ecologie Buccale, Faculté de Médecine Dentaire, Félix d' Hérelle Reference Center for Bacterial Viruses, Université Laval, Québec, Canada.
Häuser R
Ouellette M
Liu J
Dehbi M
Moeck G
García E
Titz B
Uetz P
Moineau S
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Źródło :
Journal of bacteriology [J Bacteriol] 2011 Jan; Vol. 193 (2), pp. 551-62. Date of Electronic Publication: 2010 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Streptococcus Phages/*genetics
Streptococcus pneumoniae/*virology
Chromatography, Liquid ; DNA Replication ; DNA, Viral/chemistry ; DNA, Viral/genetics ; Gene Order ; Genes, Viral ; Mass Spectrometry ; Molecular Sequence Data ; Multigene Family ; Open Reading Frames ; Promoter Regions, Genetic ; Protein Biosynthesis ; Sequence Analysis, DNA ; Siphoviridae/classification ; Siphoviridae/ultrastructure ; Streptococcus Phages/classification ; Streptococcus Phages/ultrastructure ; Terminator Regions, Genetic ; Viral Structural Proteins/analysis
Czasopismo naukowe

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