Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Toll‐like receptor 4"" wg kryterium: Temat


Tytuł :
Toll-like receptor 4: An attractive therapeutic target for acute kidney injury.
Autorzy :
Jha AK; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Gairola S; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Kundu S; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Doye P; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Syed AM; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Ram C; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Murty US; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Naidu VGM; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India.
Sahu BD; Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari PIN-781101, Assam, India. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119155. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acute Kidney Injury/*drug therapy
Acute Kidney Injury/*metabolism
Drug Delivery Systems/*methods
Toll-Like Receptor 4/*metabolism
Acute Kidney Injury/immunology ; Animals ; Drug Delivery Systems/trends ; Drugs, Chinese Herbal/administration & dosage ; Endothelial Cells/drug effects ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Glucocorticoids/administration & dosage ; Humans ; Proton Pump Inhibitors/administration & dosage ; Toll-Like Receptor 4/antagonists & inhibitors ; Toll-Like Receptor 4/immunology
Czasopismo naukowe
Tytuł :
Bisphenol A increases TLR4-mediated inflammatory response by up-regulation of autophagy-related protein in lung of adolescent mice.
Autorzy :
Wang S; Department of Child and Adolescent Health, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Yang Y; Department of Social Medicine, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Luo D; Department of Child and Adolescent Health, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Zhai L; Department of Child and Adolescent Health, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Bai Y; Department of Child and Adolescent Health, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Wei W; Department of Child and Adolescent Health, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Sun Q; Department of Child and Adolescent Health, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Jia L; Department of Child and Adolescent Health, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address: .
Pokaż więcej
Źródło :
Chemosphere [Chemosphere] 2021 Apr; Vol. 268, pp. 128837. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Toll-Like Receptor 4*/genetics
Toll-Like Receptor 4*/metabolism
Animals ; Autophagy-Related Proteins ; Benzhydryl Compounds ; Female ; Lung/metabolism ; Mice ; Mice, Inbred C57BL ; Phenols ; Up-Regulation
Czasopismo naukowe
Tytuł :
Asiaticoside ameliorates acinar cell necrosis in acute pancreatitis via toll-like receptor 4 pathway.
Autorzy :
Wu K; Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: .
Yao G; Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: .
Shi X; Department of Critical Care Medicine, PLA Key Laboratory of Emergency and Critical Care Research, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210000, PR China. Electronic address: .
Zhang H; Medical College of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: .
Zhu Q; Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: .
Liu X; Department of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, PR China. Electronic address: .
Lu G; Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: .
Hu L; Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, PR China. Electronic address: .
Gong W; Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: .
Yang Q; Department of Critical Care Medicine, PLA Key Laboratory of Emergency and Critical Care Research, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, 210000, PR China. Electronic address: .
Ding Y; Pancreatic Center, Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225009, PR China. Electronic address: .
Pokaż więcej
Źródło :
Molecular immunology [Mol Immunol] 2021 Feb; Vol. 130, pp. 122-132. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acinar Cells/*drug effects
Acinar Cells/*pathology
Pancreatitis/*pathology
Toll-Like Receptor 4/*genetics
Triterpenes/*pharmacology
Animals ; Cells, Cultured ; Cytoprotection/drug effects ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Necrosis/prevention & control ; Pancreatitis/drug therapy ; Pancreatitis/genetics ; Pancreatitis/metabolism ; Signal Transduction/genetics ; Toll-Like Receptor 4/physiology ; Triterpenes/therapeutic use
Czasopismo naukowe
Tytuł :
Canna x generalis L.H. Bailey rhizome extract ameliorates dextran sulfate sodium-induced colitis via modulating intestinal mucosal dysfunction, oxidative stress, inflammation, and TLR4/ NF-ҡB and NLRP3 inflammasome pathways.
Autorzy :
Mahmoud TN; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr Al Aini Street, Cairo, P.O. Box 11562, Egypt. Electronic address: .
El-Maadawy WH; Department of Pharmacology, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt. Electronic address: .
Kandil ZA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr Al Aini Street, Cairo, P.O. Box 11562, Egypt.
Khalil H; Department of Pathology, Theodor Bilharz Research Institute, Kornaish El Nile, Warrak El-Hadar, Imbaba (P.O. 30), Giza, 12411, Egypt.
El-Fiky NM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr Al Aini Street, Cairo, P.O. Box 11562, Egypt.
El Alfy TSMA; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr Al Aini Street, Cairo, P.O. Box 11562, Egypt.
Pokaż więcej
Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 06; Vol. 269, pp. 113670. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Colitis/*drug therapy
Dextran Sulfate/*toxicity
NF-kappa B/*antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Plant Extracts/*therapeutic use
Toll-Like Receptor 4/*antagonists & inhibitors
Animals ; Colitis/chemically induced ; Colitis/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plants, Medicinal ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Dual targeting of Toll-like receptor 4 and angiotensin-converting enzyme 2: a proposed approach to SARS-CoV-2 treatment.
Autorzy :
Kate Gadanec L; Institute for Health & Sport, Victoria University, Melbourne, Australia.
Qaradakhi T; Institute for Health & Sport, Victoria University, Melbourne, Australia.
Renee McSweeney K; Institute for Health & Sport, Victoria University, Melbourne, Australia.
Ashiana Ali B; Institute for Health & Sport, Victoria University, Melbourne, Australia.
Zulli A; Institute for Health & Sport, Victoria University, Melbourne, Australia.
Apostolopoulos V; Institute for Health & Sport, Victoria University, Melbourne, Australia.
Pokaż więcej
Źródło :
Future microbiology [Future Microbiol] 2021 Mar; Vol. 16, pp. 205-209. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Toll-Like Receptor 4/*antagonists & inhibitors
Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/metabolism ; COVID-19/virology ; Enzyme Activators/pharmacology ; Enzyme Activators/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/virology ; Molecular Targeted Therapy ; SARS-CoV-2/drug effects ; SARS-CoV-2/isolation & purification ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Toll-Like Receptor 4/metabolism
SCR Protocol :
COVID-19 drug treatment
Raport
Tytuł :
TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages.
Autorzy :
Roh KH; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Lee Y; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Yoon JH; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, 29425, USA.
Lee D; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Kim E; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Park E; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Lee IY; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Kim TS; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Song HK; Department of Life Sciences, Korea University, Seoul, 02841, Korea.
Shin J; Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, 16419, Korea.
Lim DS; Department of Biological Sciences, National Creative Research Initiatives Center, Biomedical Research Center, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea.
Choi EJ; Department of Life Sciences, Korea University, Seoul, 02841, Korea. .
Pokaż więcej
Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (5), pp. 2315-2328. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Macrophages/*metabolism
NF-kappa B/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
TNF Receptor-Associated Factor 6/*metabolism
Toll-Like Receptor 4/*metabolism
Animals ; Cells, Cultured ; Cytokines/blood ; Cytokines/genetics ; Cytokines/metabolism ; HEK293 Cells ; Humans ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Macrophages/cytology ; Macrophages/drug effects ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Protein-Serine-Threonine Kinases/genetics ; Sepsis/blood ; Sepsis/genetics ; Sepsis/metabolism ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction/drug effects ; Survival Analysis ; TNF Receptor-Associated Factor 6/genetics ; Toll-Like Receptor 4/genetics ; Ubiquitination/drug effects
Czasopismo naukowe
Tytuł :
Promoted inhibition of TLR4/miR-155/ NF k B p65 signaling by cannabinoid receptor 2 agonist (AM1241), aborts inflammation and progress of hepatic fibrosis induced by thioacetamide.
Autorzy :
Ali AM; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Egypt.
El-Tawil OS; Department of Toxicology, Forensic Medicine and Veterinary Regulations, Faculty of Veterinary Medicine, Cairo University, Egypt.
Al-Mokaddem AK; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Egypt.
Abd El-Rahman SS; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Egypt. Electronic address: .
Pokaż więcej
Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Feb 25; Vol. 336, pp. 109398. Date of Electronic Publication: 2021 Jan 24.
Typ publikacji :
Journal Article
MeSH Terms :
Inflammation/*drug therapy
Liver Cirrhosis/*drug therapy
MicroRNAs/*antagonists & inhibitors
Thioacetamide/*adverse effects
Toll-Like Receptor 4/*antagonists & inhibitors
Transcription Factor RelA/*antagonists & inhibitors
Animals ; Cannabinoids/pharmacology ; Dose-Response Relationship, Drug ; Inflammation/chemically induced ; Inflammation/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Male ; MicroRNAs/metabolism ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Structure-Activity Relationship ; Toll-Like Receptor 4/metabolism ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Tytuł :
Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis.
Autorzy :
Lu P; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA. .
Yamaguchi Y; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Fulton WB; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Wang S; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Zhou Q; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Jia H; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Kovler ML; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Salazar AG; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Sampah M; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Prindle T Jr; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Wipf P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Sodhi CP; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA.
Hackam DJ; Division of Pediatric Surgery, Johns Hopkins University School of Medicine and the Johns Hopkins Children's Center, Baltimore, MD, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1042. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*genetics
Enterocolitis, Necrotizing/*genetics
Indoles/*administration & dosage
Milk, Human/*physiology
Receptors, Aryl Hydrocarbon/*genetics
Toll-Like Receptor 4/*genetics
Animals ; Animals, Newborn ; Basic Helix-Loop-Helix Transcription Factors/agonists ; Basic Helix-Loop-Helix Transcription Factors/immunology ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A1/immunology ; Diet/methods ; Disease Models, Animal ; Enterocolitis, Necrotizing/immunology ; Enterocolitis, Necrotizing/pathology ; Enterocolitis, Necrotizing/prevention & control ; Female ; Gene Expression Regulation ; Humans ; Infant, Newborn ; Infant, Premature ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Ligands ; Maternal Exposure ; Mice ; Pregnancy ; Receptors, Aryl Hydrocarbon/agonists ; Receptors, Aryl Hydrocarbon/immunology ; Signal Transduction ; Swine ; Toll-Like Receptor 4/immunology
Czasopismo naukowe
Tytuł :
Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4.
Autorzy :
Courtney CM; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Onufer EJ; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
McDonald KG; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Steinberger AE; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Sescleifer AM; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Seiler KM; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Tecos ME; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
Newberry RD; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Warner BW; Division of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, Missouri. Electronic address: .
Pokaż więcej
Źródło :
The Journal of surgical research [J Surg Res] 2021 Feb; Vol. 258, pp. 73-81. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Intestinal Mucosa/*metabolism
Short Bowel Syndrome/*etiology
Tight Junctions/*metabolism
Toll-Like Receptor 4/*metabolism
Animals ; Mice, Inbred C57BL ; Mice, Knockout ; Permeability ; Short Bowel Syndrome/metabolism ; Tight Junctions/ultrastructure ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
Tytuł :
The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF-kappaB pathway.
Autorzy :
Dejban P; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Nikravangolsefid N; Faculty of medicine, Iran University of Medical Sciences, Tehran, Iran.
Chamanara M; Department of Pharmacology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Dehpour A; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Rashidian A; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Pokaż więcej
Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Feb; Vol. 35 (2), pp. 835-845. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Inflammatory Bowel Diseases/*drug therapy
NF-kappa B/*drug effects
Toll-Like Receptor 4/*drug effects
Animals ; Humans ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Measurement of Macrophage Toll-Like Receptor 4 Expression After Morphine Treatment.
Autorzy :
Castelli M; Department of Pharmacological and Biomolecular Science, University of Milano, Milan, Italy.
Panerai A; Department of Pharmacological and Biomolecular Science, University of Milano, Milan, Italy.
Sacerdote P; Department of Pharmacological and Biomolecular Science, University of Milano, Milan, Italy. .
Franchi S; Department of Pharmacological and Biomolecular Science, University of Milano, Milan, Italy.
Pokaż więcej
Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2201, pp. 209-217.
Typ publikacji :
Journal Article
MeSH Terms :
Macrophages/*drug effects
Real-Time Polymerase Chain Reaction/*methods
Toll-Like Receptor 4/*analysis
Analgesics, Opioid/immunology ; Analgesics, Opioid/pharmacology ; Animals ; Cytokines/biosynthesis ; Immune System Phenomena ; Immunity, Innate/drug effects ; Macrophage Activation/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Morphine/adverse effects ; Morphine/metabolism ; Morphine/pharmacology ; Receptors, Opioid/immunology ; Toll-Like Receptor 4/drug effects ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Genetic variants in the regulation region of TLR4 reduce the gastric cancer susceptibility.
Autorzy :
Li Z; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Gao H; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Liu Y; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Wu H; College of Life Science, North China University of Science and Technology, Tangshan 063210, China.
Li W; Affliated Tangshan Gongren Hospital, North China University of Science and Technology, Tangshan 063000, China.
Xing Y; Tangshan Yingcai International School, 063000, China.
Zhang Z; Affliated Tangshan Gongren Hospital, North China University of Science and Technology, Tangshan 063000, China.
Zhang X; School of Public Health, North China University of Science and Technology, Tangshan 063210, China; College of Life Science, North China University of Science and Technology, Tangshan 063210, China. Electronic address: .
Pokaż więcej
Źródło :
Gene [Gene] 2021 Jan 30; Vol. 767, pp. 145181. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Stomach Neoplasms/*genetics
Toll-Like Receptor 4/*genetics
Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; China ; Female ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Genotype ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide/genetics ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 4/metabolism ; Toll-Like Receptor 5/genetics
Czasopismo naukowe
Tytuł :
Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells.
Autorzy :
Wei YD; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Du XM; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Yang DH; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Ma FL; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Yu XW; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Zhang MF; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Li N; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Peng S; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China.
Liao MZ; College of Life Sciences, Northwest A & F University, Yangling, Shaanxi 712100, China.
Li GP; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia 010021, China.
Bai CL; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia 010021, China. E-mail:.
Liu WS; Department of Pathology, Yangling Demonstration Zone Hospital, Yangling Shaanxi 712100, China. E-mail:.
Hua JL; College of Veterinary Medicine, Northwest A & F University, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi 712100, China. E-mail:.
Pokaż więcej
Źródło :
Zoological research [Zool Res] 2021 Jan 18; Vol. 42 (1), pp. 14-27.
Typ publikacji :
Journal Article
MeSH Terms :
Adult Germline Stem Cells/*metabolism
Immunity, Innate/*physiology
Signal Transduction/*physiology
Toll-Like Receptor 4/*metabolism
Transcription Factors/*metabolism
Animals ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Gene Knockdown Techniques ; Goats ; Inflammation/metabolism ; Lipopolysaccharides/toxicity ; Male ; NF-kappa B ; Seminiferous Tubules ; Sertoli Cells/metabolism ; Toll-Like Receptor 4/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR signaling pathway in mice.
Autorzy :
Peng KY; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: .
Gu JF; Basic Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: .
Su SL; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: .
Zhu Y; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: .
Guo JM; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: .
Qian DW; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: .
Duan JA; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jan 10; Vol. 264, pp. 113052. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Salvia miltiorrhiza*
Abietanes/*administration & dosage
Colitis, Ulcerative/*drug therapy
Hydroxybenzoates/*administration & dosage
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
TOR Serine-Threonine Kinases/*antagonists & inhibitors
Toll-Like Receptor 4/*antagonists & inhibitors
Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/metabolism ; Dextran Sulfate/toxicity ; Drug Therapy, Combination ; Hydroxybenzoates/isolation & purification ; Male ; Mice ; Mice, Inbred C57BL ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors/administration & dosage ; Phosphoinositide-3 Kinase Inhibitors/isolation & purification ; Plant Extracts/administration & dosage ; Plant Extracts/isolation & purification ; Plant Leaves ; Plant Stems ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Toll-like receptor-4 deficiency inhibits ultraviolet radiation-induced tumor development by modulation of immune and inflammatory responses.
Autorzy :
Ahmad I; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nasti TH; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Rihan HM; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jimenez H; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Elmets CA; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Veteran Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Yusuf N; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Veteran Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Pokaż więcej
Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Jan; Vol. 60 (1), pp. 60-70. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Skin Neoplasms/*etiology
Skin Neoplasms/*genetics
Toll-Like Receptor 4/*genetics
Ultraviolet Rays/*adverse effects
Animals ; Carcinogenesis/genetics ; Carcinogenesis/immunology ; Carcinogenesis/radiation effects ; Gene Deletion ; Immunity ; Inflammation/etiology ; Inflammation/genetics ; Inflammation/immunology ; Mice ; Skin Neoplasms/immunology ; Toll-Like Receptor 4/immunology
Czasopismo naukowe
Tytuł :
Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury.
Autorzy :
El-Sisi AEE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Sokar SS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Shebl AM; Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Sultan Qaboos University Hospital, Muscat, Oman.
Mohamed DZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. Electronic address: .
Abu-Risha SE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Pokaż więcej
Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115340. Date of Electronic Publication: 2020 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
Melatonin/*administration & dosage
NF-kappa B/*antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Octreotide/*administration & dosage
Pyroptosis/*drug effects
Reperfusion Injury/*drug therapy
Toll-Like Receptor 4/*antagonists & inhibitors
Animals ; Antioxidants/administration & dosage ; Drug Therapy, Combination ; Inflammasomes/antagonists & inhibitors ; Inflammasomes/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pyroptosis/physiology ; Random Allocation ; Rats ; Reperfusion Injury/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Ablation of lncRNA MIAT mitigates high glucose-stimulated inflammation and apoptosis of podocyte via miR-130a-3p/TLR4 signaling axis.
Autorzy :
Zhang M; Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Zhao S; Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Xu C; Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Shen Y; Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Huang J; Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Shen S; Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Li Y; Department of Nephrology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Chen X; State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 10; Vol. 533 (3), pp. 429-436. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetic Nephropathies/*genetics
MicroRNAs/*metabolism
Podocytes/*metabolism
RNA, Long Noncoding/*metabolism
Toll-Like Receptor 4/*genetics
Animals ; Apoptosis ; Cells, Cultured ; Diabetic Nephropathies/metabolism ; Glucose/toxicity ; Inflammation Mediators/metabolism ; Mice ; Podocytes/drug effects ; RNA, Long Noncoding/antagonists & inhibitors ; Signal Transduction ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Streptococcus pneumoniae PepO promotes host anti-infection defense via autophagy in a Toll-like receptor 2/4 dependent manner.
Autorzy :
Shu Z; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Yuan J; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Wang H; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Zhang J; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Li S; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Zhang H; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Liu Y; Department of Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, China.
Yin Y; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Zhang X; Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, China.
Pokaż więcej
Źródło :
Virulence [Virulence] 2020 Dec; Vol. 11 (1), pp. 270-282.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Host Microbial Interactions*
Bacterial Proteins/*genetics
Endopeptidases/*genetics
Streptococcus pneumoniae/*immunology
Toll-Like Receptor 2/*immunology
Toll-Like Receptor 4/*immunology
Animals ; Bacterial Load ; Cytokines ; Female ; Immunity, Innate ; Macrophages/immunology ; Macrophages/microbiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phagocytosis ; Streptococcus pneumoniae/genetics ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics
Czasopismo naukowe
Tytuł :
The pre-activated immune response induced by LPS protects host from leptospirosis.
Autorzy :
Chen X; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.
Xie X; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.
Wu D; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.
Zhang S; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.
Zhang W; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.
Cao Y; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Nov 24; Vol. 15 (11), pp. e0242742. Date of Electronic Publication: 2020 Nov 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leptospira interrogans/*immunology
Leptospirosis/*immunology
Lipopolysaccharides/*pharmacology
Phagocytosis/*drug effects
Toll-Like Receptor 4/*immunology
Animals ; Cricetinae ; Interleukin-1beta/immunology ; Leptospirosis/pathology ; Mesocricetus ; Toll-Like Receptor 4/agonists ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways.
Autorzy :
Hu N; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China.
Guo C; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China.
Dai X; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China.
Wang C; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China.
Gong L; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China.
Yu L; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China.
Peng C; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China. Electronic address: .
Li Y; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, 611137, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Nov 15; Vol. 262, pp. 113275. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article
MeSH Terms :
Forsythia*
Drugs, Chinese Herbal/*therapeutic use
Liver Cirrhosis/*drug therapy
Myeloid Differentiation Factor 88/*antagonists & inhibitors
NF-kappa B/*antagonists & inhibitors
Toll-Like Receptor 4/*antagonists & inhibitors
Transforming Growth Factor beta/*antagonists & inhibitors
Animals ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Female ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Smad Proteins/antagonists & inhibitors ; Smad Proteins/metabolism ; Toll-Like Receptor 4/metabolism ; Transforming Growth Factor beta/metabolism ; Water
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies