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Wyświetlanie 1-19 z 19
Tytuł :
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden.
Autorzy :
Peneder P; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Stütz AM; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Surdez D; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.; Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Krumbholz M; Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany.
Semper S; Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany.
Chicard M; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Sheffield NC; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Pierron G; Unité de Génétique Somatique, Service d'oncogénétique, Institut Curie, Centre Hospitalier, Paris, France.
Lapouble E; Unité de Génétique Somatique, Service d'oncogénétique, Institut Curie, Centre Hospitalier, Paris, France.
Tötzl M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ergüner B; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Barreca D; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Rendeiro AF; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Agaimy A; Institute of Pathology, University Hospital Erlangen, Erlangen, Germany.
Boztug H; St. Anna Kinderspital, Department of Pediatrics, Medical University, Vienna, Austria.
Engstler G; St. Anna Kinderspital, Department of Pediatrics, Medical University, Vienna, Austria.
Dworzak M; St. Anna Kinderspital, Department of Pediatrics, Medical University, Vienna, Austria.
Bernkopf M; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Taschner-Mandl S; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Ambros IM; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Myklebost O; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.
Marec-Bérard P; Pediatric Department, Hematology and Oncology Pediatric Institute, Centre Léon Bérard, Lyon, France.
Burchill SA; Children's Cancer Research Group, Leeds Institute of Medical Research, St. James's University Hospital, Leeds, UK.
Brennan B; Department of Pediatric Oncology, Royal Manchester Children's Hospital, Manchester, UK.
Strauss SJ; Department of Oncology, UCL Cancer Institute, London, UK.; Department of Oncology, University College London Hospital, London, UK.
Whelan J; Department of Oncology, University College London Hospital, London, UK.
Schleiermacher G; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.
Schaefer C; University Hospital Essen, Pediatrics III, West German Cancer Centre, Essen, Germany.
Dirksen U; University Hospital Essen, Pediatrics III, West German Cancer Centre, Essen, Germany.
Hutter C; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.; St. Anna Kinderspital, Department of Pediatrics, Medical University, Vienna, Austria.
Boye K; Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Ambros PF; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Delattre O; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France.; Unité de Génétique Somatique, Service d'oncogénétique, Institut Curie, Centre Hospitalier, Paris, France.
Metzler M; Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. .; Institute of Artificial Intelligence, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria. .; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria. .
Tomazou EM; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria. eleni.tomazou@ccri.at.
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Źródło :
Nature communications [Nat Commun] 2021 May 28; Vol. 12 (1), pp. 3230. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor/*blood
Bone Neoplasms/*diagnosis
Circulating Tumor DNA/*blood
Sarcoma, Ewing/*diagnosis
Adolescent ; Adult ; Biomarkers, Tumor/genetics ; Bone Neoplasms/blood ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Case-Control Studies ; Child ; Child, Preschool ; Circulating Tumor DNA/genetics ; DNA Mutational Analysis ; Female ; Humans ; Infant ; Liquid Biopsy/methods ; Male ; Middle Aged ; Mutation ; Sarcoma, Ewing/blood ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/pathology ; Whole Genome Sequencing ; Young Adult
Czasopismo naukowe
Tytuł :
Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression.
Autorzy :
Terlecki-Zaniewicz S; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Humer T; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Eder T; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Schmoellerl J; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Heyes E; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Manhart G; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Kuchynka N; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Parapatics K; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Liberante FG; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Müller AC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Grebien F; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Feb; Vol. 28 (2), pp. 190-201. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeodomain Proteins*/chemistry
Homeodomain Proteins*/physiology
Leukemia*/metabolism
Leukemia*/pathology
Nuclear Pore Complex Proteins*/chemistry
Nuclear Pore Complex Proteins*/physiology
Oncogene Proteins, Fusion*/chemistry
Oncogene Proteins, Fusion*/physiology
Cell Nucleus/*metabolism
Animals ; Gene Expression ; Gene Expression Regulation, Leukemic ; HEK293 Cells ; HL-60 Cells ; Humans ; Mice ; NIH 3T3 Cells
Czasopismo naukowe
Tytuł :
Sarcoma treatment in the era of molecular medicine.
Autorzy :
Grünewald TG; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Hopp Children's Cancer Center (KiTZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Alonso M; Program in Solid Tumors and Biomarkers, Foundation for the Applied Medical Research, University of Navarra Pamplona, Pamplona, Spain.
Avnet S; Orthopedic Pathophysiology and Regenerative Medicine Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Banito A; Pediatric Soft Tissue Sarcoma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Burdach S; Department of Pediatrics and Children's Cancer Research Center (CCRC), Technische Universität München, Munich, Germany.
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Di Pompo G; Orthopedic Pathophysiology and Regenerative Medicine Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Distel M; Children's Cancer Research Institute, Vienna, Austria.
Dorado-Garcia H; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Garcia-Castro J; Cellular Biotechnology Unit, Instituto de Salud Carlos III, Madrid, Spain.
González-González L; Cellular Biotechnology Unit, Instituto de Salud Carlos III, Madrid, Spain.
Grigoriadis AE; Centre for Craniofacial and Regenerative Biology, King's College London, London, UK.
Kasan M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Koelsche C; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Krumbholz M; Department of Pediatrics, University Hospital, Erlangen, Germany.
Lecanda F; Division of Oncology, Adhesion and Metastasis Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
Lemma S; Orthopedic Pathophysiology and Regenerative Medicine Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Longo DL; Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, Italy.
Madrigal-Esquivel C; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Morales-Molina Á; Cellular Biotechnology Unit, Instituto de Salud Carlos III, Madrid, Spain.
Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Ory B; Université de Nantes, Inserm, U1238, Nantes, France.
Pereira-Silva M; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Perut F; Orthopedic Pathophysiology and Regenerative Medicine Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Rodriguez R; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.; CIBER en oncología (CIBERONC), Madrid, Spain.
Seeling C; Institute of Pathology, Ulm University, Ulm, Germany.
Al Shaaili N; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Shaabani S; Department of Drug Design, University of Groningen, Groningen, The Netherlands.
Shiavone K; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Sinha S; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Tomazou EM; Children's Cancer Research Institute, Vienna, Austria.
Trautmann M; Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany.
Vela M; Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Versleijen-Jonkers YM; Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
Visgauss J; Medical Center, Duke University, Durham, NC, USA.
Zalacain M; Institute of Biostructures and Bioimaging (IBB), Italian National Research Council (CNR), Turin, Italy.
Schober SJ; Department of Pediatrics and Children's Cancer Research Center (CCRC), Technische Universität München, Munich, Germany.
Lissat A; University Children's Hospital Zurich - Eleonoren Foundation, Kanton Zürich, Zürich, Switzerland.
English WR; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Baldini N; Orthopedic Pathophysiology and Regenerative Medicine Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Heymann D; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.; Université de Nantes, Institut de Cancérologie de l'Ouest, Tumor Heterogeneity and Precision Medicine, Saint-Herblain, France.
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Źródło :
EMBO molecular medicine [EMBO Mol Med] 2020 Nov 06; Vol. 12 (11), pp. e11131. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex.
Autorzy :
Selvanathan SP; Departments of Oncology and Pediatrics, Georgetown University, Washington, DC 20057, USA.
Graham GT; Departments of Oncology and Pediatrics, Georgetown University, Washington, DC 20057, USA.
Grego AR; Departments of Oncology and Pediatrics, Georgetown University, Washington, DC 20057, USA.
Baker TM; Caris Life Sciences, Phoenix, AZ, USA.
Hogg JR; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Simpson M; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University, Newark, NJ 07103, USA.
Batish M; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University, Newark, NJ 07103, USA.; Department of Medical and Molecular Sciences, University of Delaware, Newark, DE 19716, USA.
Crompton B; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.; Broad Institute, Cambridge, MA, USA.
Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA, USA.; Broad Institute, Cambridge, MA, USA.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Üren A; Departments of Oncology and Pediatrics, Georgetown University, Washington, DC 20057, USA.
Toretsky JA; Departments of Oncology and Pediatrics, Georgetown University, Washington, DC 20057, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Oct 10; Vol. 47 (18), pp. 9619-9636.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*genetics
Nuclear Proteins/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Transcription Factors/*genetics
Alternative Splicing/genetics ; Cell Line, Tumor ; Chromatin Assembly and Disassembly/genetics ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Nuclear Proteins/chemistry ; Oncogene Proteins, Fusion/chemistry ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; Protein Stability ; Proto-Oncogene Protein c-fli-1/chemistry ; RNA-Binding Protein EWS/chemistry ; Sarcoma, Ewing/pathology ; Transcription Factors/chemistry
Czasopismo naukowe
Tytuł :
Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.
Autorzy :
Javaheri T; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Kazemi Z; Medical University of Vienna, Vienna, Austria.; Center of Physiology and Pharmacology, Vienna, Austria.
Pencik J; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.
Pham HTT; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Kauer M; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Noorizadeh R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Sax B; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Nivarthi H; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schlederer M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.
Maurer B; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Hofbauer M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Aryee DNT; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Wiedner M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Logan M; Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
Hartmann C; Department of Bone and Skeletal Research, Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany.
Tuckermann JP; Institute of General Zoology and Endocrinology, University of Ulm, Ulm, Germany.
Kenner L; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.; University of Veterinary Medicine, Vienna, Austria.
Mikula M; Medical University of Vienna, Vienna, Austria.; Institute of Medical Genetics, Vienna, Austria.
Dolznig H; Medical University of Vienna, Vienna, Austria.; Institute of Medical Genetics, Vienna, Austria.
Üren A; Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, USA.
Richter GH; Children's Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Grebien F; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Moriggl R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria. .; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria. .; Medical University of Vienna, Vienna, Austria. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Aug 13; Vol. 10 (8), pp. 605. Date of Electronic Publication: 2019 Aug 13.
Typ publikacji :
Journal Article; Retraction of Publication
Czasopismo naukowe
Tytuł :
MIRA: an R package for DNA methylation-based inference of regulatory activity.
Autorzy :
Lawson JT; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Tomazou EM; Children's Cancer Research Institute, St. Anna's Kinderkrebsforschung, Vienna, Austria.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Sheffield NC; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2018 Aug 01; Vol. 34 (15), pp. 2649-2650.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Software*
Epigenomics/*methods
Sequence Analysis, DNA/*methods
Biological Ontologies ; Computational Biology/methods
Czasopismo naukowe
Tytuł :
Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.
Autorzy :
Javaheri T; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Kazemi Z; Medical University of Vienna, Vienna, Austria.; Center of Physiology and Pharmacology, Vienna, Austria.
Jan Pencik; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.
Pham HTT; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Kauer M; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Noorizadeh R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Sax B; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Nivarthi H; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schlederer M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.
Maurer B; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Hofbauer M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Aryee DNT; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Wiedner M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Logan M; Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
Hartmann C; Department of Bone and Skeletal Research, Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany.
Tuckermann JP; Institute of General Zoology and Endocrinology, University of Ulm, Ulm, Germany.
Kenner L; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.; University of Veterinary Medicine, Vienna, Austria.
Mikula M; Medical University of Vienna, Vienna, Austria.; Institute of Medical Genetics, Vienna, Austria.
Dolznig H; Medical University of Vienna, Vienna, Austria.; Institute of Medical Genetics, Vienna, Austria.
Üren A; Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, USA.
Richter GH; Children's Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Grebien F; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Moriggl R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria. .; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria. .; Medical University of Vienna, Vienna, Austria. .
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Źródło :
Cell death & disease [Cell Death Dis] 2018 Jul 23; Vol. 9 (8), pp. 800. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji :
Published Erratum
Tytuł :
Ewing sarcoma.
Autorzy :
Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; German Cancer Consortium, partner site Munich, Munich, Germany. .; German Cancer Research Center, Heidelberg, Germany. .
Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. .; German Cancer Consortium, partner site Munich, Munich, Germany. .; German Cancer Research Center, Heidelberg, Germany. .
Surdez D; INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Tomazou EM; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
de Álava E; Institute of Biomedicine of Seville, Virgen del Rocío University Hospital/CSIC/University of Seville/CIBERONC, Seville, Spain.
Kovar H; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University Vienna, Vienna, Austria.
Sorensen PH; British Columbia Cancer Research Centre and University of British Columbia, Vancouver, Canada.
Delattre O; INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Dirksen U; German Cancer Research Center, Heidelberg, Germany.; Cooperative Ewing Sarcoma Study group, Essen University Hospital, Essen, Germany.; German Cancer Consortium, partner site Essen, Essen, Germany.
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Źródło :
Nature reviews. Disease primers [Nat Rev Dis Primers] 2018 Jul 05; Vol. 4 (1), pp. 5. Date of Electronic Publication: 2018 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Sarcoma, Ewing/*diagnosis
12E7 Antigen/analysis ; 12E7 Antigen/blood ; Humans ; Neoplasm Metastasis/physiopathology ; Proto-Oncogene Protein c-fli-1/analysis ; Proto-Oncogene Protein c-fli-1/blood ; Quality of Life/psychology ; RNA-Binding Protein EWS/analysis ; RNA-Binding Protein EWS/blood ; Radiography/methods ; Risk Factors ; Sarcoma, Ewing/blood ; Sarcoma, Ewing/physiopathology
Czasopismo naukowe
Tytuł :
EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma.
Autorzy :
Katschnig AM; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Kauer MO; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Schwentner R; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Mutz CN; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.
Linder M; Institute of Cancer Research, Medical University Vienna, Vienna, Austria.
Sibilia M; Institute of Cancer Research, Medical University Vienna, Vienna, Austria.
Alonso J; Unidad de Tumores Solidos Infantiles, Instituto de Investigación de Enfermedades Raras, Madrid, Spain.
Aryee DNT; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.; Department of Paediatrics, Medical University Vienna, Vienna, Austria.
Kovar H; Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.; Department of Paediatrics, Medical University Vienna, Vienna, Austria.
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Źródło :
Oncogene [Oncogene] 2017 Oct 26; Vol. 36 (43), pp. 5995-6005. Date of Electronic Publication: 2017 Jul 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming/*genetics
Cytoskeleton/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Actins/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Chromatin/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Sarcoma, Ewing/pathology ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.
Autorzy :
Sheffield NC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Pierron G; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Klughammer J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Datlinger P; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schönegger A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schuster M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Hadler J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Surdez D; Institut Curie, PSL Research University, INSERM, U830, Paris, France.
Guillemot D; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Lapouble E; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.
Freneaux P; Institut Curie, PSL Research University, Service de Pathologie, Pole de Medecine Diagnostique et Theranostique, Paris, France.
Champigneulle J; Service d'Anatomie et de Cytologie Pathologiques, Hopitaux de Brabois, Hopital d'Adultes, Nancy, France.
Bouvier R; Centre de Pathologie du Pôle Est, Hopitaux de Lyon, Lyon, France.
Walder D; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Ambros IM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Hutter C; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Sorz E; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Amaral AT; Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla, Seville, Spain.
de Álava E; Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla, Seville, Spain.
Schallmoser K; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.; Department of Blood Group Serology and Transfusion Medicine, Paracelsus Medical University, Salzburg, Austria.
Strunk D; Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.; Institute for Experimental and Clinical Cell Therapy, Paracelsus Medical University, Salzburg, Austria.
Rinner B; Division of Biomedical Research, Medical University of Graz, Graz, Austria.
Liegl-Atzwanger B; Institute of Pathology, Medical University of Graz, Graz, Austria.
Huppertz B; Organizational Unit of Research Infrastructure, Biobank Graz, Medical University of Graz, Graz, Austria.
Leithner A; Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria.
de Pinieux G; Service d'Anatomie et de Cytologie Pathologiques, Hôpital Universitaire Trousseau, Tours, France.
Terrier P; Gustave Roussy, Département de Pathologie, Villejuif, France.
Laurence V; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.; Institut Curie, PSL Research University, Departement d'Oncologie Pédiatrique Adolescent Jeunes Adultes, Paris, France.
Michon J; Institut Curie, PSL Research University, Departement d'Oncologie Pédiatrique Adolescent Jeunes Adultes, Paris, France.
Ladenstein R; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Holter W; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; St. Anna Children's Hospital, St. Anna Kinderspital, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Windhager R; Department of Orthopedics, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Dirksen U; University Hospital Münster, Department of Pediatrics and Pediatric Hematology and Oncology, Münster, Germany.
Ambros PF; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Delattre O; Institut Curie, PSL Research University, Service de Genetique, Pole de Medecine Diagnostique et Theranostique, Unité de Génétique Somatique, Paris, France.; Institut Curie, PSL Research University, INSERM, U830, Paris, France.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.; Max Planck Institute for Informatics, Saarland Informatics Campus, Saarbrücken, Germany.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
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Źródło :
Nature medicine [Nat Med] 2017 Mar; Vol. 23 (3), pp. 386-395. Date of Electronic Publication: 2017 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Bone Neoplasms/*genetics
DNA Methylation/*genetics
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Protein c-fli-1/*genetics
RNA-Binding Protein EWS/*genetics
Sarcoma, Ewing/*genetics
Adolescent ; Adult ; Cell Line, Tumor ; Child ; Child, Preschool ; Epigenesis, Genetic ; Female ; Genetic Heterogeneity ; Humans ; Male ; Middle Aged ; Promoter Regions, Genetic/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation.
Autorzy :
Javaheri T; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Kazemi Z; Medical University of Vienna, Vienna, Austria.; Center of Physiology and Pharmacology, Vienna, Austria.
Pencik J; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.
Pham HT; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Kauer M; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Noorizadeh R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Sax B; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Nivarthi H; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Schlederer M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.
Maurer B; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Hofbauer M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Aryee DN; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Wiedner M; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
Logan M; Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
Hartmann C; Department of Bone and Skeletal Research, Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany.
Tuckermann JP; Institute of General Zoology and Endocrinology, University of Ulm, Ulm, Germany.
Kenner L; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.; Clinical Institute of Pathology, Vienna, Austria.; University of Veterinary Medicine, Vienna, Austria.
Mikula M; Medical University of Vienna, Vienna, Austria.; Institute of Medical Genetics, Vienna, Austria.
Dolznig H; Medical University of Vienna, Vienna, Austria.; Institute of Medical Genetics, Vienna, Austria.
Üren A; Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, USA.
Richter GH; Children's Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Grebien F; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.; Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Moriggl R; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.; Medical University of Vienna, Vienna, Austria.
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Źródło :
Cell death & disease [Cell Death Dis] 2016 Oct 13; Vol. 7 (10), pp. e2419. Date of Electronic Publication: 2016 Oct 13.
Typ publikacji :
Journal Article; Retracted Publication
MeSH Terms :
Cell Cycle*
Cell Transformation, Neoplastic/*pathology
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA-Binding Protein EWS/*metabolism
Animals ; Animals, Newborn ; Apoptosis ; Bone and Bones/pathology ; Cell Cycle Checkpoints ; Cell Differentiation ; Cell Proliferation ; Cell Survival ; Cell Transformation, Neoplastic/metabolism ; Extremities/pathology ; Gene Expression Profiling ; Gene Knockdown Techniques ; Human Embryonic Stem Cells/metabolism ; Humans ; Mesenchymal Stem Cells/metabolism ; Mice ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Osteogenesis ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.
Autorzy :
Tomazou EM; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria.
Sheffield NC; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Schmidl C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Schuster M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Schönegger A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Datlinger P; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria; Max Planck Institute for Informatics, 66123 Saarbrücken, Germany. Electronic address: .
Kovar H; Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2015 Feb 24; Vol. 10 (7), pp. 1082-95. Date of Electronic Publication: 2015 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Epigenesis, Genetic*
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA-Binding Protein EWS/*metabolism
Acetylation ; Cell Line, Tumor ; Chromatin/metabolism ; Chromosome Mapping ; Cluster Analysis ; DNA Methylation ; Down-Regulation/drug effects ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylases/chemistry ; Histone Deacetylases/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Oncogene Proteins, Fusion/genetics ; Promoter Regions, Genetic ; Proto-Oncogene Protein c-fli-1/genetics ; RNA, Small Interfering/metabolism ; RNA-Binding Protein EWS/genetics ; Sarcoma, Ewing/metabolism ; Sarcoma, Ewing/pathology ; Transcription Factor AP-1/genetics ; Transcription Factor AP-1/metabolism ; Transcriptome/drug effects
Czasopismo naukowe
Tytuł :
Quantitative comparison of genome-wide DNA methylation mapping technologies.
Autorzy :
Bock C; Broad Institute, Cambridge, Massachusetts, USA. />Tomazou EM
Brinkman AB
Müller F
Simmer F
Gu H
Jäger N
Gnirke A
Stunnenberg HG
Meissner A
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Źródło :
Nature biotechnology [Nat Biotechnol] 2010 Oct; Vol. 28 (10), pp. 1106-14. Date of Electronic Publication: 2010 Sep 19.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation/*genetics
Genome, Human/*genetics
Sequence Analysis, DNA/*methods
Aged, 80 and over ; Cell Line ; Humans ; Male ; Repetitive Sequences, Nucleic Acid/genetics ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Epigenetic regulation of pluripotency.
Autorzy :
Tomazou EM; Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusettes, 02138, USA.
Meissner A
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2010; Vol. 695, pp. 26-40.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Epigenesis, Genetic*
Pluripotent Stem Cells*/metabolism
DNA Methylation ; Embryonic Stem Cells/metabolism ; Histones/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex.
Autorzy :
Ottaviani D; Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.
Lever E
Mitter R
Jones T
Forshew T
Christova R
Tomazou EM
Rakyan VK
Krawetz SA
Platts AE
Segarane B
Beck S
Sheer D
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Źródło :
Genome research [Genome Res] 2008 Nov; Vol. 18 (11), pp. 1778-86. Date of Electronic Publication: 2008 Oct 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Major Histocompatibility Complex*
B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Cell Line ; Chromatin/chemistry ; Chromatin/genetics ; Fibroblasts/drug effects ; Fibroblasts/immunology ; Genes, MHC Class II ; Genome, Human ; HLA Antigens/genetics ; Humans ; Interferon-gamma/pharmacology ; Matrix Attachment Regions/drug effects ; Models, Genetic ; Recombinant Proteins ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs).
Autorzy :
Rakyan VK; Institute of Cell and Molecular Science, Barts and the London, London E1 2AT, United Kingdom. />Down TA
Thorne NP
Flicek P
Kulesha E
Gräf S
Tomazou EM
Bäckdahl L
Johnson N
Herberth M
Howe KL
Jackson DK
Miretti MM
Fiegler H
Marioni JC
Birney E
Hubbard TJ
Carter NP
Tavaré S
Beck S
Pokaż więcej
Źródło :
Genome research [Genome Res] 2008 Sep; Vol. 18 (9), pp. 1518-29. Date of Electronic Publication: 2008 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Genome, Human*
Software*
Algorithms ; CpG Islands ; DNA/metabolism ; Epigenesis, Genetic ; Gene Expression Profiling/methods ; Humans
Czasopismo naukowe
Tytuł :
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis.
Autorzy :
Down TA; Wellcome Trust Cancer Research UK Gurdon Institute, and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. />Rakyan VK
Turner DJ
Flicek P
Li H
Kulesha E
Gräf S
Johnson N
Herrero J
Tomazou EM
Thorne NP
Bäckdahl L
Herberth M
Howe KL
Jackson DK
Miretti MM
Marioni JC
Birney E
Hubbard TJ
Durbin R
Tavaré S
Beck S
Pokaż więcej
Źródło :
Nature biotechnology [Nat Biotechnol] 2008 Jul; Vol. 26 (7), pp. 779-85.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
DNA Methylation*
Chromatin Immunoprecipitation/*methods
Chromosome Mapping/*methods
DNA/*genetics
Pattern Recognition, Automated/*methods
Sequence Analysis, DNA/*methods
Base Sequence ; Bayes Theorem ; Molecular Sequence Data
Czasopismo naukowe
Tytuł :
Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis.
Autorzy :
Tomazou EM; The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. />Rakyan VK
Lefebvre G
Andrews R
Ellis P
Jackson DK
Langford C
Francis MD
Bäckdahl L
Miretti M
Coggill P
Ottaviani D
Sheer D
Murrell A
Beck S
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Źródło :
BMC medical genomics [BMC Med Genomics] 2008 May 30; Vol. 1, pp. 19. Date of Electronic Publication: 2008 May 30.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Look who's talking too: graduates developing skills through communication.
Autorzy :
Tomazou EM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK. />Powell GT
Pokaż więcej
Źródło :
Nature reviews. Genetics [Nat Rev Genet] 2007 Sep; Vol. 8 (9), pp. 724-6. Date of Electronic Publication: 2007 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Academic Dissertations as Topic*
Clinical Competence*
Communication*
Education, Graduate*
Congresses as Topic ; Humans ; Publications ; Research ; Societies, Scientific
Czasopismo naukowe
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