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Wyświetlanie 1-20 z 49
Tytuł:
Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway.
Autorzy:
Tong L; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Li W; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Zhang Y; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Zhou F; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Zhao Y; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Zhao L; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Liu J; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Song Z; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Yu M; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Zhou C; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
Yu A; Department of Clinical Pharmacy, General Hospital of Central Theater Command, Wuhan, Hubei 430000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Sep; Vol. 24 (3). Date of Electronic Publication: 2021 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Insulin/*metabolism
Insulin Secretion/*drug effects
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Tacrolimus/*pharmacology
Animals ; Caspase 3/metabolism ; Cell Line, Tumor ; Diabetes Mellitus ; Insulinoma/drug therapy ; Insulinoma/metabolism ; Mice ; Oxidative Stress ; Phosphorylation ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein.
Autorzy:
Nie PY; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Tong L; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Li MD; Department of 1st Clinical Medicine, China Medical University, Shenyang, China.
Fu CH; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Peng JB; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Ji LL; Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2021 Jan 06; Vol. 18 (1), pp. 17. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*physiology
Cytokines/*biosynthesis
Fragile X Mental Retardation Protein/*biosynthesis
Hippocampus/*metabolism
MicroRNAs/*biosynthesis
Stress Disorders, Post-Traumatic/*metabolism
Animals ; Cells, Cultured ; Cytokines/antagonists & inhibitors ; Cytokines/genetics ; Down-Regulation/physiology ; Fragile X Mental Retardation Protein/genetics ; Gene Expression ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/prevention & control ; Male ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; PC12 Cells ; Rats ; Rats, Sprague-Dawley ; Stress Disorders, Post-Traumatic/genetics ; Stress Disorders, Post-Traumatic/prevention & control ; Up-Regulation/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Stable silencing of TIPE2 reduced the Poly I:C‑induced apoptosis in THP‑1 cells.
Autorzy:
Jiang J; Department of ICU, Affiliated Hospital of Medical College of Ningbo University, Ningbo, Zhejiang 315020, P.R. China.
Wang S; Department of ICU, Affiliated Hospital of Medical College of Ningbo University, Ningbo, Zhejiang 315020, P.R. China.
Fang J; Department of ICU, Affiliated Hospital of Medical College of Ningbo University, Ningbo, Zhejiang 315020, P.R. China.
Xu Y; Department of Emergency, Affiliated Hospital of Medical College of Ningbo University, Ningbo, Zhejiang 315020, P.R. China.
Tong L; Department of Pharmacology, Ningbo Institute of Medical Sciences, Ningbo University, Ningbo, Zhejiang 315020, P.R. China.
Ye X; Department of Pharmacology, Ningbo Institute of Medical Sciences, Ningbo University, Ningbo, Zhejiang 315020, P.R. China.
Zhou W; Department of Medicine, College of Medicine and Health, Lishui University, Lishui, Zhejiang 323000, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Nov; Vol. 16 (5), pp. 6313-6319. Date of Electronic Publication: 2017 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Intracellular Signaling Peptides and Proteins/*genetics
Poly I-C/*pharmacology
Apoptosis/genetics ; Caspase 8/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Humans ; THP-1 Cells ; Toll-Like Receptors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Giganteaside D induces ROS-mediated apoptosis in human hepatocellular carcinoma cells through the MAPK pathway.
Autorzy:
Liu J; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Wei X; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Wu Y; Inpatient Department, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, People's Republic of China.
Wang Y; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Qiu Y; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Shi J; Southern Institute of Pharmaceutical Research, South China Normal University, Guangzhou, 510631, People's Republic of China.
Zhou H; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Lu Z; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Shao M; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China. .
Yu L; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China. .
Tong L; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2016 Aug; Vol. 39 (4), pp. 333-42. Date of Electronic Publication: 2016 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
MAP Kinase Signaling System/*drug effects
Reactive Oxygen Species/*metabolism
Saponins/*pharmacology
Apoptosis/physiology ; Blotting, Western ; Carcinoma, Hepatocellular/metabolism ; Extracellular Signal-Regulated MAP Kinases/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Flow Cytometry ; Hep G2 Cells ; Humans ; Liver Neoplasms/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Patrinia/chemistry ; Phytotherapy/methods ; Plant Roots/chemistry ; RNA, Small Interfering ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 49

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