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Tytuł:
The Subchronic Toxic Effects of Mosla chinensis Maxim in Normal Rats.
Autorzy:
Lei D; Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Li L; Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Huang S; Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Liu L; Jiangxi Medical Service Guidance Center, Nanchang 330006, China.
Cai P; School of Science and Technology, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Gu Z; Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Shu K; Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Li S; Jiangxi Children's Hospital, Nanchang 330006, China.
Hong T; Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Liu Z; Jiangxi University of Chinese Medicine, Nanchang 330004, China.; Jiangxi Provincial Key Laboratory of Traditional Chinese Medicine Pharmacology, Nanchang 330004, China.
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Źródło:
BioMed research international [Biomed Res Int] 2020 Dec 28; Vol. 2020, pp. 4521586. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Toxicity Tests, Chronic*
Drugs, Chinese Herbal/*toxicity
Lamiaceae/*chemistry
Animals ; Biomarkers/blood ; Biomarkers/urine ; Blood Glucose/metabolism ; Body Weight/drug effects ; Drugs, Chinese Herbal/administration & dosage ; Energy Metabolism/drug effects ; Female ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Motility/drug effects ; Hematologic Tests ; Immunity/drug effects ; Kidney/drug effects ; Kidney/physiopathology ; Lipids/blood ; Liver/drug effects ; Liver/physiopathology ; Organ Specificity/drug effects ; Oxidation-Reduction/drug effects ; Principal Component Analysis ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oral Chronic Toxicity of the Safe Tetrodotoxin Dose Proposed by the European Food Safety Authority and Its Additive Effect with Saxitoxin.
Autorzy:
Boente-Juncal A; Laboratorio de Farmacología, Farmacia e Tecnoloxía Farmacéutica, Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario s/n, 27002 Lugo, Spain.
Otero P; Laboratorio de Farmacología, Farmacia e Tecnoloxía Farmacéutica, Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario s/n, 27002 Lugo, Spain.
Rodríguez I; Laboratorios Cifga, Benigno Rivera, 56. 27003 Lugo, Spain.
Camiña M; Departamento de Fisiología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain.
Rodriguez-Vieytes M; Departamento de Fisiología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain.
Vale C; Laboratorio de Farmacología, Farmacia e Tecnoloxía Farmacéutica, Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario s/n, 27002 Lugo, Spain.
Botana LM; Laboratorio de Farmacología, Farmacia e Tecnoloxía Farmacéutica, Universidade de Santiago de Compostela, Facultad de Veterinaria, Campus Universitario s/n, 27002 Lugo, Spain.
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Źródło:
Toxins [Toxins (Basel)] 2020 May 09; Vol. 12 (5). Date of Electronic Publication: 2020 May 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Food Contamination*
Toxicity Tests, Chronic*
Saxitoxin/*toxicity
Tetrodotoxin/*toxicity
Administration, Oral ; Animals ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Food Chain ; Humans ; Mice ; No-Observed-Adverse-Effect Level ; Risk Assessment ; Saxitoxin/administration & dosage ; Tetrodotoxin/administration & dosage ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Preclinical safety evaluation of amphotericin A21: A novel antifungal.
Autorzy:
Ortega-Blake I; Institute of Physical Sciences, National Autonomous University of Mexico, Cuernavaca, Mexico.
Fernández-Zertuche M; Chemical Research Center, Autonomous University of the State of Morelos, Cuernavaca, Mexico.
Regla I; Faculty of Higher Studies Zaragoza, National Autonomous University of Mexico, Cuernavaca, Mexico.
Sánchez-Peña W; Pharmacy School, Autonomous University of the State of Morelos, Cuernavaca, Mexico.
Gómez-Solis A; Pharmacy School, Autonomous University of the State of Morelos, Cuernavaca, Mexico.
Jaimes-Chavez P; Pharmacy School, Autonomous University of the State of Morelos, Cuernavaca, Mexico.
Galván-Hernández A; Institute of Physical Sciences, National Autonomous University of Mexico, Cuernavaca, Mexico.
Tovar-Garduño E; Chemical Research Center, Autonomous University of the State of Morelos, Cuernavaca, Mexico.
Rodríguez-Fragoso L; Pharmacy School, Autonomous University of the State of Morelos, Cuernavaca, Mexico.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2021 Jul; Vol. 129 (1), pp. 72-81. Date of Electronic Publication: 2021 May 04.
Typ publikacji:
Journal Article
MeSH Terms:
Amphotericin B/*toxicity
Antifungal Agents/*toxicity
Administration, Oral ; Amphotericin B/administration & dosage ; Amphotericin B/analogs & derivatives ; Animals ; Antifungal Agents/administration & dosage ; Male ; Rats ; Toxicity Tests, Chronic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions.
Autorzy:
Duivenvoorde LPM; Wageningen Food Safety Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands. .
Louisse J; Wageningen Food Safety Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
Pinckaers NET; Wageningen Food Safety Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
Nguyen T; Wageningen Food Safety Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
van der Zande M; Wageningen Food Safety Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
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Źródło:
Scientific reports [Sci Rep] 2021 May 14; Vol. 11 (1), pp. 10327. Date of Electronic Publication: 2021 May 14.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Culture Techniques/*methods
Hepatocytes/*drug effects
Toxicity Tests, Chronic/*methods
Cell Line, Tumor ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P450 Family 1/genetics ; Cytochrome P450 Family 1/metabolism ; Drug Evaluation, Preclinical/methods ; Gene Expression Regulation ; Hepatocytes/enzymology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A dose-escalating toxicology study of the candidate biologic ELP-VEGF.
Autorzy:
Waller JP; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Burke SP; Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Engel J; Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Chade AR; Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.; Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.; Department of Radiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Bidwell GL 3rd; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. .; Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. .; Department of Cell and Molecular Biology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 18; Vol. 11 (1), pp. 6216. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Biological Products/*pharmacology
Breast Neoplasms/*blood supply
Elastin/*genetics
Neovascularization, Pathologic/*chemically induced
Recombinant Fusion Proteins/*pharmacology
Renal Insufficiency, Chronic/*drug therapy
Vascular Endothelial Growth Factor A/*genetics
Animals ; Biological Products/metabolism ; Blood Pressure/drug effects ; Body Weight/drug effects ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Capillary Permeability/drug effects ; Disease Models, Animal ; Elastin/metabolism ; Female ; Gene Expression ; Glomerular Filtration Rate/drug effects ; Heterografts ; Humans ; Hypotension/chemically induced ; Hypotension/diagnostic imaging ; Hypotension/physiopathology ; Mice ; Molecular Mimicry ; Neovascularization, Pathologic/diagnostic imaging ; Neovascularization, Pathologic/pathology ; Neovascularization, Physiologic/drug effects ; Rats ; Rats, Sprague-Dawley ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Renal Insufficiency, Chronic/diagnostic imaging ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/physiopathology ; Swine ; Toxicity Tests, Chronic ; Vascular Endothelial Growth Factor A/metabolism ; X-Ray Microtomography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chronic trichlorfon stress induces differential transcriptome expression and interferes with multifunctional pathways in the brain of Rana chensinensis .
Autorzy:
Ma Y; College of Life Science, Shaanxi Normal University, Xi'an, China.; Microbiological Technology Center, Shaanxi Microbiology Institute, Xi'an, China.
Li B; College of Life Science, Shaanxi Normal University, Xi'an, China.; Microbiological Technology Center, Shaanxi Microbiology Institute, Xi'an, China.
Ke Y; Microbiological Technology Center, Shaanxi Microbiology Institute, Xi'an, China.
Zhu HY; Microbiological Technology Center, Shaanxi Microbiology Institute, Xi'an, China.
Zhang YH; College of Life Science, Shaanxi Normal University, Xi'an, China.
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Źródło:
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes [J Environ Sci Health B] 2021; Vol. 56 (1), pp. 1-9. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji:
Journal Article
MeSH Terms:
Brain/*drug effects
Environmental Pollutants/*toxicity
Insecticides/*toxicity
Transcriptome/*drug effects
Trichlorfon/*toxicity
Animals ; Brain/metabolism ; Brain/pathology ; Gene Expression/drug effects ; Humans ; Ranidae ; Toxicity Tests, Chronic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution.
Autorzy:
Edwards S; Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, USA.
Zhao G; Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, USA.; Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, P.R. China.
Tran J; Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, USA.; University of Portland, Portland, Oregon, USA.
Patten KT; Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Valenzuela A; Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Wallis C; Air Quality Research Center, University of California, Davis, Davis, California, USA.
Bein KJ; Air Quality Research Center, University of California, Davis, Davis, California, USA.; Center for Health and the Environment, University of California, Davis, Davis, California, USA.
Wexler AS; Air Quality Research Center, University of California, Davis, Davis, California, USA.; Mechanical and Aerospace Engineering, Civil and Environmental Engineering, and Land, Air and Water Resources, University of California, Davis, Davis, California, USA.
Lein PJ; Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Rao X; Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, USA.; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
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Źródło:
Environmental health perspectives [Environ Health Perspect] 2020 Dec; Vol. 128 (12), pp. 127003. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Vehicle Emissions*
Air Pollution/*statistics & numerical data
Animals ; Exercise Test ; Female ; Male ; Rats ; Toxicity Tests, Chronic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chronic Effects of Coated Silver Nanoparticles on Marine Invertebrate Larvae: A Proof of Concept Study.
Autorzy:
Chan CY; Department of Biology, Hong Kong Baptist University, Kowloon, Hong Kong.
Chiu JM; Department of Biology, Hong Kong Baptist University, Kowloon, Hong Kong.
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Źródło:
PloS one [PLoS One] 2015 Jul 14; Vol. 10 (7), pp. e0132457. Date of Electronic Publication: 2015 Jul 14 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Toxicity Tests, Chronic*
Invertebrates/*drug effects
Metal Nanoparticles/*toxicity
Silver/*chemistry
Silver/*toxicity
Animals ; Biological Transport ; Body Burden ; Haptophyta/metabolism ; Invertebrates/growth & development ; Invertebrates/metabolism ; Larva/drug effects ; Larva/growth & development ; Silver/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments.
Autorzy:
Audira G; Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Ngoc Anh NT; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Ngoc Hieu BT; Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Malhotra N; Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Siregar P; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Villalobos O; Department of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines.
Villaflores OB; Department of Biochemistry, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines.
Ger TR; Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Center of Nanotechnology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Huang JC; Department of Applied Chemistry, National Pingtung University, Pingtung 900391, Taiwan.
Chen KH; Department of Applied Chemistry, National Pingtung University, Pingtung 900391, Taiwan.
Hsiao CD; Department of Chemistry, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 320314, Taiwan.; Center of Nanotechnology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
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Źródło:
Biomolecules [Biomolecules] 2020 Sep 18; Vol. 10 (9). Date of Electronic Publication: 2020 Sep 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Behavior, Animal/*drug effects
Brain/*drug effects
Donepezil/*toxicity
Environmental Exposure/*adverse effects
Toxicity Tests, Chronic/*methods
Zebrafish/*physiology
Animals ; Brain/metabolism ; Cholinesterase Inhibitors/toxicity ; Locomotion/drug effects ; Locomotion/physiology ; Malondialdehyde/metabolism ; Memory, Short-Term/drug effects ; Memory, Short-Term/physiology ; Motor Activity/drug effects ; Motor Activity/physiology ; Muscles/drug effects ; Muscles/metabolism ; Muscles/physiology ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AhR-activating pesticides increase the bovine ABCG2 efflux activity in MDCKII-bABCG2 cells.
Autorzy:
Kuhnert L; Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University Leipzig, Leipzig, Germany.
Giantin M; Division of Veterinary Pharmacology and Toxicology, Department of Comparative Biomedicine and Food Science, University of Padua, Agripolis Legnaro (Padua), Italy.
Dacasto M; Division of Veterinary Pharmacology and Toxicology, Department of Comparative Biomedicine and Food Science, University of Padua, Agripolis Legnaro (Padua), Italy.
Halwachs S; Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University Leipzig, Leipzig, Germany.
Honscha W; Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University Leipzig, Leipzig, Germany.
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Źródło:
PloS one [PLoS One] 2020 Aug 07; Vol. 15 (8), pp. e0237163. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Animal Testing Alternatives/*methods
Fungicides, Industrial/*toxicity
Receptors, Aryl Hydrocarbon/*agonists
Toxicity Tests, Chronic/*methods
ATP Binding Cassette Transporter, Subfamily G, Member 2/agonists ; Animals ; Cattle ; Dogs ; Germany ; Lactation/drug effects ; Madin Darby Canine Kidney Cells ; Receptors, Aryl Hydrocarbon/metabolism ; Recombinant Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metabonomics analysis of liver in rats administered with chronic low-dose acrylamide.
Autorzy:
Liu Y; Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Wang R; Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Zheng K; Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Xin Y; Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Jia S; Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Zhao X; Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, China.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Aug; Vol. 50 (8), pp. 894-905. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Acrylamide/*metabolism
Acrylamide/administration & dosage ; Acrylamide/toxicity ; Animals ; Biomarkers/metabolism ; Dose-Response Relationship, Drug ; Lipid Metabolism/drug effects ; Liver/metabolism ; Male ; Metabolome/drug effects ; Metabolomics ; Oxidative Stress ; Rats ; Rats, Wistar ; Toxicity Tests, Chronic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chronic in vivo exposure to Helicobacter pylori VacA: Assessing the efficacy of automated and long-term intragastric toxin infusion.
Autorzy:
Holland RL; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Bosi KD; Department of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Harpring GH; Department of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Luo J; Department of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Wallig M; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Phillips H; Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA.
Blanke SR; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA. .; Department of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA. .; Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, 61801, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jun 09; Vol. 10 (1), pp. 9307. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacterial Proteins/*toxicity
Parietal Cells, Gastric/*drug effects
Animals ; Automation ; Bacterial Proteins/administration & dosage ; Bacterial Proteins/analysis ; Catheters ; Female ; Gastric Mucosa/drug effects ; Gastric Mucosa/pathology ; Infusions, Parenteral ; Intubation, Gastrointestinal ; Kidney/drug effects ; Kidney/pathology ; Liver/drug effects ; Liver/pathology ; Lung/drug effects ; Lung/pathology ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Parietal Cells, Gastric/pathology ; Stomach/drug effects ; Stomach/pathology ; Toxicity Tests, Chronic ; Vacuoles/drug effects ; Vacuoles/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification of metabolite biomarkers in serum of rats exposed to chlorpyrifos and cadmium.
Autorzy:
Xu MY; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, P.R. China.
Wang P; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, P.R. China.
Sun YJ; Department of Veterinary Medicine and Animal Science, Beijing University of Agriculture, Beijing, 102206, P.R. China.
Yang L; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, P.R. China.
Wu YJ; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, P.R. China. .
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Źródło:
Scientific reports [Sci Rep] 2020 Mar 19; Vol. 10 (1), pp. 4999. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cadmium/*toxicity
Chlorpyrifos/*toxicity
Cholinesterase Reactivators/*toxicity
Environmental Exposure/*adverse effects
Environmental Pollutants/*toxicity
Malonates/*blood
Propionates/*blood
Serine/*blood
Toxicity Tests, Chronic/*methods
Animals ; Biomarkers/blood ; Cadmium/administration & dosage ; Chlorpyrifos/administration & dosage ; Energy Metabolism/drug effects ; Environmental Pollutants/administration & dosage ; Gas Chromatography-Mass Spectrometry ; Male ; Rats, Sprague-Dawley ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies.
Autorzy:
Portier CJ; Rollins School of Public Health, Emory University, Atlanta, GA, USA. .; Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands. .; CJP Consulting, Seattle, Washington, USA. .
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Źródło:
Environmental health : a global access science source [Environ Health] 2020 Feb 12; Vol. 19 (1), pp. 18. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Carcinogenicity Tests/*statistics & numerical data
Glycine/*analogs & derivatives
Herbicides/*toxicity
Toxicity Tests, Chronic/*statistics & numerical data
Animals ; Glycine/toxicity ; Mice ; Rats ; Glyphosate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The progressive alteration of urine metabolomic profiles of rats following long-term and low-dose exposure to permethrin.
Autorzy:
Liang YJ; Department of Veterinary Medicine and Animal Science, Beijing University of Agriculture, Beijing, PR China.; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
Wang P; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
Long DX; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
Wang HP; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
Sun YJ; Department of Veterinary Medicine and Animal Science, Beijing University of Agriculture, Beijing, PR China.
Wu YJ; Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
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Źródło:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2020 Feb; Vol. 25 (1), pp. 94-99. Date of Electronic Publication: 2019 Dec 01.
Typ publikacji:
Journal Article
MeSH Terms:
Insecticides/*toxicity
Metabolome/*drug effects
Permethrin/*toxicity
Animals ; Biomarkers/urine ; Male ; Metabolomics ; Proton Magnetic Resonance Spectroscopy ; Rats, Wistar ; Risk Assessment ; Time Factors ; Toxicity Tests, Chronic ; Urinalysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Behavioral Impairments and Oxidative Stress in the Brain, Muscle, and Gill Caused by Chronic Exposure of C 70 Nanoparticles on Adult Zebrafish.
Autorzy:
Sarasamma S; Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Audira G; Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Samikannu P; Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Juniardi S; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Siregar P; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Hao E; Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning 530200, China.; Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine, Nanning 530200, China.
Chen JR; Department of Biological Science & Technology College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
Hsiao CD; Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.; Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning 530200, China.; Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine, Nanning 530200, China.; Center for Biomedical Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.; Center for Nanotechnology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Nov 18; Vol. 20 (22). Date of Electronic Publication: 2019 Nov 18.
Typ publikacji:
Journal Article
MeSH Terms:
Behavior, Animal/*drug effects
Fullerenes/*toxicity
Oxidative Stress/*drug effects
Zebrafish/*physiology
Animals ; Brain/drug effects ; Brain/metabolism ; Environmental Exposure/adverse effects ; Exploratory Behavior/drug effects ; Female ; Gills/drug effects ; Gills/metabolism ; Hydrocortisone/metabolism ; Locomotion/drug effects ; Male ; Metal Nanoparticles ; Muscles/drug effects ; Muscles/metabolism ; Toxicity Tests, Chronic ; Zebrafish/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chronic toxicity of inhaled thymol in lungs and respiratory tracts in mouse model.
Autorzy:
Xie K; Amphastar New Drug Research Center (NDRC) Chino CA USA.
Tashkin DP; Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine University of California at Los Angeles Los Angeles CA USA.
Luo MZ; Amphastar Pharmaceuticals, Inc. Rancho Cucamonga CA USA.
Zhang JY; Amphastar Pharmaceuticals, Inc. Rancho Cucamonga CA USA.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2019 Aug 27; Vol. 7 (5), pp. e00516. Date of Electronic Publication: 2019 Aug 27 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epinephrine/*chemistry
Lung/*drug effects
Respiratory System/*drug effects
Thymol/*toxicity
Administration, Inhalation ; Animals ; Case-Control Studies ; Female ; Lung/cytology ; Male ; Mice ; Models, Animal ; Respiratory System/cytology ; Toxicity Tests, Chronic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Subchronic toxicity study in rats of two new ethyl-carbamates with ixodicidal activity.
Autorzy:
Prado-Ochoa MG; Programa de Maestría y Doctorado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autónoma de México, 04510 Ciudad Universitaria, D.F., Mexico.
Abrego-Reyes VH; Laboratorio de Química Medicinal, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico.
Velázquez-Sánchez AM; Laboratorio de Química Medicinal, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico.
Muñoz-Guzmán MA; Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico.
Ramírez-Noguera P; Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico.
Angeles E; Laboratorio de Química Medicinal, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico.
Alba-Hurtado F; Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico.
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Źródło:
BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 467105. Date of Electronic Publication: 2014 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Toxicity Tests, Chronic*
Acaricides/*toxicity
Urethane/*toxicity
Animals ; Body Weight/drug effects ; Drinking Behavior/drug effects ; Feeding Behavior/drug effects ; Female ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Molecular Weight ; Organ Size/drug effects ; Rats, Wistar ; Thiobarbituric Acid Reactive Substances/metabolism ; Urethane/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization.
Autorzy:
Scarlata MJ; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Lee SH; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Lee D; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Kandigian SE; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Hiller AJ; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Dishart JG; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Mintz GE; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Wang Z; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Coste GI; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Mousley AL; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Soler I; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Lawson K; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Ng AJ; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Bezek JL; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA.
Bergstrom HC; Vassar College, Department of Psychological Science, Program in Neuroscience and Behavior, Poughkeepsie, NY, 12604, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Apr 30; Vol. 9 (1), pp. 6730. Date of Electronic Publication: 2019 Apr 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ethanol/*toxicity
Fear/*drug effects
Memory/*physiology
Prefrontal Cortex/*drug effects
Alcoholism/psychology ; Amygdala/physiology ; Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Conditioning, Classical/physiology ; Cytoskeletal Proteins/metabolism ; Drug Design ; Extinction, Psychological/physiology ; Fear/physiology ; Fear/psychology ; Generalization, Psychological ; Male ; Memory/drug effects ; Mice, Inbred C57BL ; Nerve Tissue Proteins/metabolism ; Prefrontal Cortex/physiology ; Stress Disorders, Post-Traumatic/physiopathology ; Stress Disorders, Post-Traumatic/psychology ; Toxicity Tests, Chronic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 264

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