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Tytuł :
The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells.
Autorzy :
Li X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
He X; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Chen S; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Le Y; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Bryant MS; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Guo L; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA.
Witt KL; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
Mei N; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 58-68. Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP1A1/*metabolism
Cytochrome P-450 CYP1A2/*metabolism
Gene Expression Regulation, Enzymologic/*drug effects
Luteolin/*toxicity
Adenosine Triphosphate/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 7/genetics ; Caspase 7/metabolism ; Cell Line ; Cell Survival ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A2/genetics ; DNA Damage/drug effects ; Humans ; Luteolin/chemistry ; Micronuclei, Chromosome-Defective ; Molecular Structure ; Mutagens
Czasopismo naukowe
Tytuł :
Exploration of zebrafish larvae as an alternative whole-animal model for nephrotoxicity testing.
Autorzy :
Bauer B; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Liedtke D; Institute of Human Genetics, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Jarzina S; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Stammler E; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Kreisel K; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Lalomia V; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Diefenbacher M; Chair of Biochemistry and Molecular Biology, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Klopocki E; Institute of Human Genetics, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Mally A; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 69-81. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Zebrafish*
Cadherins/*metabolism
Toxicity Tests/*methods
Zebrafish Proteins/*metabolism
Animals ; Biomarkers/metabolism ; Cadherins/genetics ; Central Nervous System ; Gene Expression Regulation, Developmental/drug effects ; Kidney/drug effects ; Larva ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
Advances in sulfur mustard-induced DNA adducts: Characterization and detection.
Autorzy :
Cheng X; Department of Biology and Chemistry, College of Liberal Arts and Sciences, National University of Defense Technology, Changsha, 410073, PR China; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China.
Liu C; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China.
Yang Y; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China.
Liang L; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China.
Chen B; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China.
Yu H; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China.
Xia J; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China.
Liu S; State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, PR China. Electronic address: .
Li Y; Department of Biology and Chemistry, College of Liberal Arts and Sciences, National University of Defense Technology, Changsha, 410073, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 46-57. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Adducts*
Chemical Warfare Agents/*toxicity
Mustard Gas/*toxicity
Animals ; Biomarkers/blood ; Humans
Czasopismo naukowe
Tytuł :
The mycoestrogen zeranol at high dosage antagonizes transient receptor potential channel activities in 3T3 L1 cells.
Autorzy :
Li Q; Biochemistry Programme, School of Life Sciences, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Tan YQ; Food and Nutritional Sciences Programme, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Cheung KK; Food and Nutritional Sciences Programme, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Chiu-Leung LC; Marine Science, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Leung LK; Food and Nutritional Sciences Programme, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; Biochemistry Programme, School of Life Sciences, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 18-25. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogens, Non-Steroidal/*toxicity
Transient Receptor Potential Channels/*antagonists & inhibitors
Zeranol/*toxicity
3T3-L1 Cells ; Animals ; Biological Transport/drug effects ; Calcium/metabolism ; Capsaicin/pharmacology ; Drug Tapering ; Estradiol/pharmacology ; Estrogens, Non-Steroidal/administration & dosage ; Gene Expression Regulation/drug effects ; Inhibitory Concentration 50 ; Mice ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Transient Receptor Potential Channels/agonists ; Transient Receptor Potential Channels/metabolism ; Zeranol/administration & dosage
Czasopismo naukowe
Tytuł :
Cylindrospermopsin impairs tubular transport function in kidney cells LLC-PK1.
Autorzy :
Moraes ACN; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Freire DS; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Habibi H; Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Lowe J; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Magalhães VF; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 26-33. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Epithelial Cells/*drug effects
Kidney Tubules, Proximal/*cytology
Albumins/metabolism ; Animals ; Biological Transport/drug effects ; Cell Death/drug effects ; Cell Line ; Gene Expression Regulation, Enzymologic/drug effects ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism ; Swine
Czasopismo naukowe
Tytuł :
Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice.
Autorzy :
Chen C; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, PR China.
Chen Y; College of Chemistry & Molecular Engineering, Peking University, Beijing, China.
Lu J; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, PR China.
Chen Z; Zhejiang Pharmaceutical College, Ningbo, 315100, China.
Wang C; College of Chemistry & Molecular Engineering, Peking University, Beijing, China. Electronic address: .
Pi R; School of Medicine, Sun Yat-Sen University, Guangzhou, 518000, China; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-Sen University, Guangzhou, China; International Joint Laboratoryof Novel Anti-Dementia Drugs of Guangzhou, Guangzhou, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 11-17. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Aging*
Alzheimer Disease*
Acrolein/*toxicity
Hippocampus/*metabolism
Proteomics/*methods
Amyloid beta-Protein Precursor ; Animals ; Hippocampus/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Neurotoxicity studies with a tropomyosin-related kinase A inhibitor, ASP7962, on the sympathetic and sensory nervous systems in rats.
Autorzy :
Kigami D; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan. Electronic address: .
Butt MT; Tox Path Specialists, A StageBio Company, Frederick, MD, United States of America.
Brown DL; Charles River Laboratories, Inc., Durham, NC, United States of America.
Matsumoto M; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan.
Ito H; Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki, Japan.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 34-45. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Neurons, Afferent/*drug effects
Receptor, trkA/*antagonists & inhibitors
Sympathetic Nervous System/*drug effects
Animals ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Male ; Neurons/drug effects ; Neurotoxicity Syndromes/metabolism ; Rats ; Rats, Sprague-Dawley ; Stellate Ganglion/cytology ; Stellate Ganglion/drug effects ; Superior Cervical Ganglion/cytology ; Superior Cervical Ganglion/drug effects ; Trigeminal Ganglion/drug effects
Czasopismo naukowe
Tytuł :
Fetal methylphenidate exposure induced ADHD-like phenotypes and decreased Drd2 and Slc6a3 expression levels in mouse offspring.
Autorzy :
Aoki S; Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan. Electronic address: .
Kaizaki-Mitsumoto A; Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan. Electronic address: .
Hattori N; Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan. Electronic address: .
Numazawa S; Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 15; Vol. 344, pp. 1-10. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Prenatal Exposure Delayed Effects*
Attention Deficit Disorder with Hyperactivity/*chemically induced
Dopamine Plasma Membrane Transport Proteins/*metabolism
Methylphenidate/*toxicity
Receptors, Dopamine D2/*metabolism
Animals ; Animals, Newborn ; Dopamine Plasma Membrane Transport Proteins/genetics ; Female ; Fetal Development/drug effects ; Gene Expression Regulation, Developmental/drug effects ; Learning ; Male ; Methylphenidate/administration & dosage ; Mice ; Mice, Inbred ICR ; Pregnancy ; Receptors, Dopamine D2/genetics
Czasopismo naukowe
Tytuł :
Theoretical modeling of structure-toxicity relationship of cyanides.
Autorzy :
Molski M; Quantum Chemistry Department, Faculty of Chemistry, Adam Mickiewicz University of Poznań, ul. Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 03; Vol. 349, pp. 30-39. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Modulation of NAD biosynthesis activates SIRT1 and resist cisplatin-induced ototoxicity.
Autorzy :
Zhan T; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xiong H; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
Pang J; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Zhang W; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Ye Y; School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Liang Z; Department of Otolaryngology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Huang X; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
He F; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Jian B; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
He W; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Gao Y; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Min X; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Zheng Y; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China; Department of Hearing and Speech-Language Science, Xinhua College, Sun Yat-sen University, China. Electronic address: .
Yang H; Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China; Department of Hearing and Speech-Language Science, Xinhua College, Sun Yat-sen University, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 02. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity.
Autorzy :
Ahmadi A; College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Niknahad H; College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Li H; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mobasheri A; Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, FI-90014, Oulu, Finland; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, LT-08406, Vilnius, Lithuania.
Manthari RK; Department of Biotechnology,GITAM Institute of Science, Visakhapatnam, 530045, Andhra Pradesh, India.
Azarpira N; Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mousavi K; College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Khalvati B; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Zhao Y; Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, College of Veterinary Medicine, Shanxi Agricultural University, Taiyuan, 030031, Shanxi, China.
Sun J; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Zong Y; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ommati MM; College of Life Sciences, Shanxi Agricultural University, Taigu, Shanxi, 030801, China; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: .
Heidari R; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 02. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Corrigendum to "Bioactivation of trichloroethylene to three regioisomeric glutathione conjugates by liver fractions and recombinant human glutathione transferases: Species differences and implications for human risk assessment" [Toxicol. Lett. 341 (2021) 94-106].
Autorzy :
Capinha L; Division of Molecular Toxicology, Amsterdam Institute for Molecules Medicines and Systems (AIMMS), Faculty of Sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands.
Jennings P; Division of Molecular Toxicology, Amsterdam Institute for Molecules Medicines and Systems (AIMMS), Faculty of Sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands.
Commandeur JNM; Division of Molecular Toxicology, Amsterdam Institute for Molecules Medicines and Systems (AIMMS), Faculty of Sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ, Amsterdam, the Netherlands. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 67-68. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Published Erratum
Tytuł :
Identification of human cytochrome P450 isozymes involved in the oxidative metabolism of carfentanil.
Autorzy :
Kong L; Research and Technology Directorate, Combat Capabilities Development Command Chemical Biological Center, U. S. Army, Aberdeen Proving Ground, MD, 21010-5424, United States. Electronic address: .
Walz AJ; Research and Technology Directorate, Combat Capabilities Development Command Chemical Biological Center, U. S. Army, Aberdeen Proving Ground, MD, 21010-5424, United States.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 28-33. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics, Opioid/*metabolism
Cytochrome P-450 CYP2C9/*metabolism
Cytochrome P-450 CYP3A/*metabolism
Fentanyl/*analogs & derivatives
Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP3A/genetics ; Fentanyl/chemistry ; Fentanyl/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Humans ; Molecular Structure ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Paternal nicotine exposure promotes hepatic fibrosis in offspring.
Autorzy :
Zhang D; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Dai J; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China; Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, 225 E Chicago Ave, Chicago, IL, 60611, USA.
Zhang M; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xie Y; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Cao Y; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
He G; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Xu W; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Wang L; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Qiao Z; Renji Hospital, South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai, 201112, China.
Qiao Z; School of Life Science and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 44-55. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Paternal Exposure*
Liver Cirrhosis/*chemically induced
Nicotine/*toxicity
Nicotinic Agonists/*toxicity
Animals ; Down-Regulation ; Epigenesis, Genetic ; Gene Expression Regulation/drug effects ; Male ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Wnt4 Protein/genetics ; Wnt4 Protein/metabolism
Czasopismo naukowe
Tytuł :
Human metabolism and urinary excretion kinetics of di-n-butyl adipate (DnBA) after oral and dermal administration in three volunteers.
Autorzy :
Ringbeck B; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. Electronic address: .
Bury D; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. Electronic address: .
Gotthardt A; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Hayen H; Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, 48149, Münster, Germany. Electronic address: .
Otter R; BASF SE, Industrial Petrochemicals Europe, Carl-Bosch-Straße 38, 67056, Ludwigshafen, Germany. Electronic address: .
Weiss T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. Electronic address: .
Brüning T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. Electronic address: .
Koch HM; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 11-20. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Adipates/*metabolism
Adipates/*pharmacokinetics
Adipates/administration & dosage ; Adipates/urine ; Administration, Oral ; Administration, Topical ; Adult ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
Changes and relationship of N -methyladenosine modification and long non-coding RNAs in oxidative damage induced by cadmium in pancreatic β-cells.
Autorzy :
Qu T; Institute of Preventive Medicine, School of Public Health, Dali University, Dali, Yunnan, China.
Mou Y; Institute of Preventive Medicine, School of Public Health, Dali University, Dali, Yunnan, China.
Dai J; Qujing Medical College, Qujing, Yunnan, China.
Zhang X; Institute of Preventive Medicine, School of Public Health, Dali University, Dali, Yunnan, China.
Li M; Institute of Preventive Medicine, School of Public Health, Dali University, Dali, Yunnan, China.
Gu S; Institute of Preventive Medicine, School of Public Health, Dali University, Dali, Yunnan, China. Electronic address: .
He Z; Institute of Preventive Medicine, School of Public Health, Dali University, Dali, Yunnan, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 56-66. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine/*analogs & derivatives
Cadmium Compounds/*toxicity
Insulin-Secreting Cells/*drug effects
Oxidative Stress/*drug effects
RNA, Long Noncoding/*metabolism
Sulfates/*toxicity
Adenosine/chemistry ; Adenosine/metabolism ; Animals ; Apoptosis/drug effects ; Cell Survival/drug effects ; Computational Biology ; Insulin-Secreting Cells/metabolism ; Mice ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat.
Autorzy :
Noorlander A; Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands. Electronic address: .
Wesseling S; Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands.
Rietjens IMCM; Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands.
van Ravenzwaay B; Experimental Toxicology and Ecology, BASF SE, Z 470, 67056, Ludwigshafen, Germany.
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 34-43. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Kidney/*metabolism
Organic Cation Transporter 2/*metabolism
Piperidines/*pharmacokinetics
Plant Growth Regulators/*pharmacokinetics
Animals ; Cell Line ; Epithelial Cells/metabolism ; Humans ; Kidney Tubules, Proximal/cytology ; Models, Biological ; Organic Cation Transporter 2/genetics ; Piperidines/urine ; Rats
Czasopismo naukowe
Tytuł :
Ocular toxicity of mustard gas: A concise review.
Autorzy :
Fuchs A; One-Health Vision Research Program, Departments of Veterinary Medicine & Surgery and Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Giuliano EA; Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States; One-Health Vision Research Program, Departments of Veterinary Medicine & Surgery and Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Sinha NR; Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States; One-Health Vision Research Program, Departments of Veterinary Medicine & Surgery and Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States.
Mohan RR; Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States; One-Health Vision Research Program, Departments of Veterinary Medicine & Surgery and Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States; Mason Eye Institute, School of Medicine, University of Missouri, Columbia, MO, United States. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 21-27. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chemical Warfare Agents/*toxicity
Eye Diseases/*chemically induced
Mustard Gas/*toxicity
Drug Administration Schedule ; Humans
Czasopismo naukowe
Tytuł :
Mechanism of hepatotoxicity of first-line tyrosine kinase inhibitors: Gefitinib and afatinib.
Autorzy :
Zhang Y; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Cai Y; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhang SR; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Li CY; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Jiang LL; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 211816, China.
Wei P; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
He MF; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jun 01; Vol. 343, pp. 1-10. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Afatinib/*toxicity
Chemical and Drug Induced Liver Injury/*pathology
Embryo, Nonmammalian/*drug effects
Gefitinib/*toxicity
Liver/*drug effects
Protein Kinase Inhibitors/*toxicity
Animals ; Animals, Genetically Modified ; Gene Expression Regulation/drug effects ; Liver/pathology ; Zebrafish/embryology
Czasopismo naukowe
Tytuł :
First insight on in vitro metabolism of three newly identified aryl organophosphate esters via a suspect coupled with nontarget screening approach.
Autorzy :
Li J; Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China.
Zhang Y; Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China.
Meng W; Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China.
Su G; Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 May 31; Vol. 348, pp. 73-84. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article
Czasopismo naukowe

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