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Tytuł:
Digital spatial profiling of segmental outflow regions in trabecular meshwork reveals a role for ADAM15.
Autorzy:
Faralli JA; Departments of Pathology & Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
Filla MS; Departments of Pathology & Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
Yang YF; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States of America.
Sun YY; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States of America.
Johns K; Departments of Pathology & Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.
Keller KE; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States of America.
Peters DM; Departments of Pathology & Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States of America.; Ophthalmology & Visual Sciences, University of Wisconsin, Madison, Wisconsin, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Feb 23; Vol. 19 (2), pp. e0298802. Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Trabecular Meshwork*/metabolism
Aqueous Humor*/metabolism
Humans ; Sclera ; Proteoglycans/metabolism ; Integrins/genetics ; Integrins/metabolism ; Intraocular Pressure ; Membrane Proteins/metabolism ; ADAM Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A simple dissection method for the isolation of mouse trabecular meshwork cells.
Autorzy:
Binter M; Institute of Ophthalmology, Hannover Medical School, University Eye Hospital, Hannover, Germany.
Langer F; Institute of Ophthalmology, Hannover Medical School, University Eye Hospital, Hannover, Germany.
Hu X; Institute of Ophthalmology, Hannover Medical School, University Eye Hospital, Hannover, Germany.
Lindziute M; Institute of Ophthalmology, Hannover Medical School, University Eye Hospital, Hannover, Germany.
Framme C; Institute of Ophthalmology, Hannover Medical School, University Eye Hospital, Hannover, Germany.
Tode J; Institute of Ophthalmology, Hannover Medical School, University Eye Hospital, Hannover, Germany.
Fuchs H; Institute of Ophthalmology, Hannover Medical School, University Eye Hospital, Hannover, Germany.
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Źródło:
PloS one [PLoS One] 2023 Dec 21; Vol. 18 (12), pp. e0296124. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Trabecular Meshwork*/metabolism
Glaucoma*/surgery
Glaucoma*/metabolism
Mice ; Animals ; Actins/metabolism ; Cornea/metabolism ; Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High VEGF Concentrations Accelerate Human Trabecular Meshwork Fibrosis in a TAZ-Dependent Manner.
Autorzy:
Sung MS; Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Republic of Korea.
Kim SY; Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Republic of Korea.
Eom GH; Department of Pharmacology, Chonnam National University Medical School, Hwasun 58128, Republic of Korea.
Park SW; Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 01; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 01.
Typ publikacji:
Journal Article
MeSH Terms:
Adaptor Proteins, Signal Transducing*/metabolism
Trabecular Meshwork*/metabolism
Vascular Endothelial Growth Factor A*/metabolism
Humans ; Actins/metabolism ; Cells, Cultured ; Extracellular Matrix Proteins/metabolism ; Fibrosis ; Intracellular Signaling Peptides and Proteins/metabolism ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; YAP-Signaling Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells.
Autorzy:
Filla MS; Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Faralli JA; Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Dunn CR; Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Khan H; Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Peters DM; Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.; Ophthalmology & Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
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Źródło:
Cells [Cells] 2023 Feb 03; Vol. 12 (3). Date of Electronic Publication: 2023 Feb 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Dexamethasone*/pharmacology
Trabecular Meshwork*/metabolism
Humans ; Cells, Cultured ; Transcription Factors/metabolism ; Cyclosporine/pharmacology ; Cyclosporine/metabolism ; Cell Cycle ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; NFATC Transcription Factors/metabolism ; Transforming Growth Factor beta2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Downregulation of COL12A1 and COL13A1 by a selective EP2 receptor agonist, omidenepag, in human trabecular meshwork cells.
Autorzy:
Kumon M; Product Development Division, Santen Pharmaceutical Co., Ltd., Nara, Japan.
Fuwa M; Product Development Division, Santen Pharmaceutical Co., Ltd., Nara, Japan.
Shimazaki A; Product Development Division, Santen Pharmaceutical Co., Ltd., Nara, Japan.
Odani-Kawabata N; Product Development Division, Santen Pharmaceutical Co., Ltd., Osaka, Japan.
Iwamura R; Pharmaceutical Division, Pharmaceuticals Research Laboratory, UBE Corporation, Yamaguchi, Japan.
Yoneda K; Pharmaceutical Division, Pharmaceuticals Research Laboratory, UBE Corporation, Yamaguchi, Japan.
Kato M; Product Development Division, Santen Pharmaceutical Co., Ltd., Nara, Japan.
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Źródło:
PloS one [PLoS One] 2023 Jan 11; Vol. 18 (1), pp. e0280331. Date of Electronic Publication: 2023 Jan 11 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Trabecular Meshwork*/metabolism
Glaucoma*/drug therapy
Glaucoma*/genetics
Glaucoma*/metabolism
Humans ; Down-Regulation ; Intraocular Pressure ; Aqueous Humor/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Collagen Type XII/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor.
Autorzy:
Liu M; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Honjo M; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Yamagishi R; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Igarashi N; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Ophthalmology, Tokyo Teishin Hospital, Tokyo 102-0071, Japan.
Nakamura N; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Division of Vision Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo 152-8902, Japan.
Kurano M; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Yatomi Y; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Igarashi K; Bioscience Division, Reagent Development Department, AIA Research Group, TOSOH Corporation, Ayaseshi 252-1123, Japan.
Aihara M; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
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Źródło:
Biomolecules [Biomolecules] 2022 Sep 03; Vol. 12 (9). Date of Electronic Publication: 2022 Sep 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aqueous Humor*/metabolism
Phosphoric Diester Hydrolases*/metabolism
Trabecular Meshwork*/metabolism
Trabecular Meshwork*/pathology
Transforming Growth Factor beta3*/metabolism
Actins/metabolism ; Cells, Cultured ; Collagen Type I/metabolism ; Fibronectins/metabolism ; Fibrosis ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Effects of Cannabidiol on Aqueous Humor Outflow and Trabecular Meshwork Cell Signaling.
Autorzy:
Aebersold AS; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
Song ZH; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
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Źródło:
Cells [Cells] 2022 Sep 27; Vol. 11 (19). Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Cannabidiol*/pharmacology
Trabecular Meshwork*/metabolism
Animals ; Aqueous Humor/metabolism ; Myosin Light Chains/metabolism ; Myosin-Light-Chain Phosphatase/metabolism ; Myosin-Light-Chain Phosphatase/pharmacology ; Signal Transduction ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Citicoline Eye Drops Protect Trabecular Meshwork Cells from Oxidative Stress Injury in a 3D In Vitro Glaucoma Model.
Autorzy:
Vernazza S; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
Passalacqua M; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
Tirendi S; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
Marengo B; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
Domenicotti C; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
Sbardella D; IRCCS-Fondazione Bietti, 00198 Rome, Italy.
Oddone F; IRCCS-Fondazione Bietti, 00198 Rome, Italy.
Bassi AM; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 27; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Glaucoma*/drug therapy
Trabecular Meshwork*
Cytidine Diphosphate Choline/pharmacology ; Cytokines/pharmacology ; Humans ; Hydrogen Peroxide/pharmacology ; Intraocular Pressure ; Ophthalmic Solutions/pharmacology ; Oxidative Stress ; Reactive Oxygen Species/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
All- trans Retinoic Acids Synergistically and Beneficially Affect In Vitro Glaucomatous Trabecular Meshwork (TM) Models Using 2D and 3D Cell Cultures of Human TM Cells.
Autorzy:
Watanabe M; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Sato T; Departments of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.; Departments of Cellular Physiology and Signal Transduction, Sapporo Medical University, Sapporo 060-8556, Japan.
Tsugeno Y; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Higashide M; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Furuhashi M; Departments of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Umetsu A; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Suzuki S; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Ida Y; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Hikage F; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
Ohguro H; Departments of Ophthalmology, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 31; Vol. 23 (17). Date of Electronic Publication: 2022 Aug 31.
Typ publikacji:
Journal Article
MeSH Terms:
Glaucoma*/metabolism
Trabecular Meshwork*/metabolism
Cell Culture Techniques, Three Dimensional ; Cells, Cultured ; Humans ; Transforming Growth Factor beta2/metabolism ; Transforming Growth Factor beta2/pharmacology ; Tretinoin/metabolism ; Tretinoin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
NEDD9 Mediates the FAK/Src Signaling Pathway to Promote the Adhesion of Human Trabecular Meshwork Cells after Dexamethasone Treatment.
Autorzy:
Tan S; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P. R. China.
Wang P; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P. R. China.
Hu J; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P. R. China.
Wang X; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P. R. China.
Li H; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P. R. China.
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Źródło:
Current eye research [Curr Eye Res] 2022 Aug; Vol. 47 (8), pp. 1156-1164. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Glaucoma, Open-Angle*/metabolism
Signal Transduction*
Trabecular Meshwork*/metabolism
Cells, Cultured ; Dexamethasone/pharmacology ; Glucocorticoids/metabolism ; Glucocorticoids/pharmacology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
TGFβ2 Regulates Human Trabecular Meshwork Cell Contractility via ERK and ROCK Pathways with Distinct Signaling Crosstalk Dependent on the Culture Substrate.
Autorzy:
Li H; Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
Henty-Ridilla JL; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.
Bernstein AM; Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Syracuse VA Medical Center, New York VA Health Care, Syracuse, NY, USA.
Ganapathy PS; Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.
Herberg S; Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.; BioInspired Institute, Syracuse University, Syracuse, NY, USA.; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, USA.
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Źródło:
Current eye research [Curr Eye Res] 2022 Aug; Vol. 47 (8), pp. 1165-1178. Date of Electronic Publication: 2022 May 19.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Glaucoma, Open-Angle*/metabolism
Trabecular Meshwork*
Actins/metabolism ; Cells, Cultured ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Hydrogels/pharmacology ; Signal Transduction/physiology ; Transforming Growth Factor beta2/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Detailed 3D micro-modeling of rat aqueous drainage channels based on two-photon imaging: simulating aqueous humor through trabecular meshwork and Schlemm's canal by two-way fluid structure interaction approach.
Autorzy:
Zhang J; School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. .
Qian X; School of Biomedical Engineering, Beijing Key Laboratory of Fundamental Research On Biomechanics in Clinical Application, Capital Medical University, Beijing, 100069, China.
Zhang H; School of Biomedical Engineering, Beijing Key Laboratory of Fundamental Research On Biomechanics in Clinical Application, Capital Medical University, Beijing, 100069, China.
Chu H; School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.; Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Xu H; School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. h_.
Liu Z; School of Biomedical Engineering, Beijing Key Laboratory of Fundamental Research On Biomechanics in Clinical Application, Capital Medical University, Beijing, 100069, China. .
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Źródło:
Medical & biological engineering & computing [Med Biol Eng Comput] 2022 Jul; Vol. 60 (7), pp. 1915-1927. Date of Electronic Publication: 2022 May 06.
Typ publikacji:
Journal Article
MeSH Terms:
Glaucoma*/diagnostic imaging
Trabecular Meshwork*/diagnostic imaging
Animals ; Aqueous Humor ; Hydrodynamics ; Intraocular Pressure ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of pigmentation intensity of trabecular meshwork cells on mechanisms of micropulse laser trabeculoplasty.
Autorzy:
Shimizu S; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Honjo M; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. .
Sugimoto K; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Okamoto M; Tomey Corporation, Nagoya, Japan.
Aihara M; Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
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Źródło:
Scientific reports [Sci Rep] 2022 Jun 22; Vol. 12 (1), pp. 10535. Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Trabecular Meshwork*/metabolism
Trabeculectomy*
Cells, Cultured ; Extracellular Matrix Proteins/metabolism ; Humans ; Intraocular Pressure ; Lasers ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism ; Pigmentation ; Tissue Inhibitor of Metalloproteinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Short and long-term effect of dexamethasone on the transcriptome profile of primary human trabecular meshwork cells in vitro.
Autorzy:
Kathirvel K; Department of Ocular Pharmacology, Aravind Medical Research Foundation, #1, Anna Nagar, Madurai, Tamil Nadu, 625020, India.; Department of Bioinformatics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.
Lester K; Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, UK.
Haribalaganesh R; Department of Ocular Pharmacology, Aravind Medical Research Foundation, #1, Anna Nagar, Madurai, Tamil Nadu, 625020, India.
Krishnadas R; Glaucoma Clinic, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Muthukkaruppan V; Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.
Lane B; Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie NHS Foundation Trust Hospital, University of Manchester, Manchester, M20 4BX, UK.; Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK.
Simpson DA; School of Medicine, Dentistry and Biomedical Sciences, The Wellcome - Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
Goljanek-Whysall K; School of Medicine, Physiology, National University of Ireland Galway, Galway, H91 W5P7, Ireland.; Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK.
Sheridan C; Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK.
Bharanidharan D; Department of Bioinformatics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.
Willoughby CE; Genomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland, UK. .; Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK. .
Senthilkumari S; Department of Ocular Pharmacology, Aravind Medical Research Foundation, #1, Anna Nagar, Madurai, Tamil Nadu, 625020, India. ss_.
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Źródło:
Scientific reports [Sci Rep] 2022 May 18; Vol. 12 (1), pp. 8299. Date of Electronic Publication: 2022 May 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glaucoma*/chemically induced
Glaucoma*/drug therapy
Glaucoma*/genetics
Trabecular Meshwork*/metabolism
Cells, Cultured ; Dexamethasone/adverse effects ; Glucocorticoids/metabolism ; Humans ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork-A review.
Autorzy:
Keller KE; Casey Eye Institute, Oregon Health &Science University, Portland, Oregon, USA.
Peters DM; Department of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin, USA.
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Źródło:
Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2022 Mar; Vol. 50 (2), pp. 163-182. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Glaucoma*/metabolism
Trabecular Meshwork*/metabolism
Aqueous Humor/metabolism ; Extracellular Matrix/metabolism ; Humans ; Intraocular Pressure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice.
Autorzy:
Ikegami K; Department of Physiology, School of Medicine, Aichi Medical University, 1-1 Yazako-karimata, Nagakute, Aichi, 480-1195, Japan. .
Masubuchi S; Department of Physiology, School of Medicine, Aichi Medical University, 1-1 Yazako-karimata, Nagakute, Aichi, 480-1195, Japan.
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Źródło:
Communications biology [Commun Biol] 2022 Apr 08; Vol. 5 (1), pp. 339. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glaucoma*
Trabecular Meshwork*/metabolism
Animals ; Guanine Nucleotide Exchange Factors/metabolism ; Intraocular Pressure ; Mice ; Norepinephrine/metabolism ; Norepinephrine/pharmacology ; Phagocytosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Relationships between Intraocular Pressure, Effective Filtration Area, and Morphological Changes in the Trabecular Meshwork of Steroid-Induced Ocular Hypertensive Mouse Eyes.
Autorzy:
Ren R; Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.
Humphrey AA; Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.
Swain DL; Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.
Gong H; Department of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 13; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Intraocular Pressure*/drug effects
Glaucoma/*etiology
Glaucoma/*metabolism
Steroids/*adverse effects
Trabecular Meshwork/*metabolism
Trabecular Meshwork/*pathology
Animals ; Basement Membrane/metabolism ; Basement Membrane/pathology ; Basement Membrane/ultrastructure ; Biomarkers ; Body Weight/drug effects ; Dexamethasone/adverse effects ; Dexamethasone/pharmacology ; Dexamethasone/therapeutic use ; Disease Models, Animal ; Disease Susceptibility ; Fluorescent Antibody Technique ; Glaucoma/diagnosis ; Mice ; Steroids/therapeutic use ; Trabecular Meshwork/ultrastructure
Czasopismo naukowe
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Tytuł:
An Innovative In Vitro Open-Angle Glaucoma Model (IVOM) Shows Changes Induced by Increased Ocular Pressure and Oxidative Stress.
Autorzy:
Vernazza S; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.
Tirendi S; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
Passalacqua M; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
Piacente F; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.
Scarfì S; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.; Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy.
Oddone F; IRCCS-Fondazione Bietti, Via Livenza 3, 00198 Rome, Italy.
Bassi AM; Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy.; Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Pisa, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 09; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Glaucoma, Open-Angle/*drug therapy
Neuroprotective Agents/*pharmacology
Oxidative Stress/*drug effects
Trabecular Meshwork/*drug effects
Apoptosis/drug effects ; Cell Line ; Eye/metabolism ; Eye/pathology ; Glaucoma, Open-Angle/genetics ; Glaucoma, Open-Angle/metabolism ; Glaucoma, Open-Angle/pathology ; Humans ; Intraocular Pressure/drug effects ; Trabecular Meshwork/metabolism ; Trabecular Meshwork/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of Missense Extracellular Matrix Gene Variants in a Large Glaucoma Pedigree and Investigation of the N700S Thrombospondin-1 Variant in Normal and Glaucomatous Trabecular Meshwork Cells.
Autorzy:
Wirtz MK; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Sykes R; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Samples J; Elson Floyd College of Medicine, Washington State University, Spokane, Washington, USA.
Edmunds B; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Choi D; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.; OHSU-PSU School of Public Health Oregon Health & Science University, Portland, Oregon, USA.; Graduate School of Dentistry, Kyung Hee University, Seoul, Korea.
Keene DR; Shriners Hospitals for Children, Portland, Oregon, USA.
Tufa SF; Shriners Hospitals for Children, Portland, Oregon, USA.
Sun YY; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Keller KE; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA.
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Źródło:
Current eye research [Curr Eye Res] 2022 Jan; Vol. 47 (1), pp. 79-90. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation, Missense*
Aqueous Humor/*metabolism
DNA/*genetics
Extracellular Matrix Proteins/*genetics
Glaucoma, Open-Angle/*genetics
Thrombospondin 1/*genetics
Trabecular Meshwork/*metabolism
Adult ; Aged ; Blotting, Western ; Cells, Cultured ; DNA Mutational Analysis ; Extracellular Matrix Proteins/metabolism ; Female ; Glaucoma, Open-Angle/metabolism ; Humans ; Intraocular Pressure/physiology ; Male ; Middle Aged ; Pedigree ; Thrombospondin 1/metabolism ; Trabecular Meshwork/cytology
Czasopismo naukowe
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Tytuł:
Primary Human Trabecular Meshwork Model for Pseudoexfoliation.
Autorzy:
Chakraborty M; Hyderabad Eye Research Foundation (HERF), L.V. Prasad Eye Institute, Bhubaneswar 751024, India.; School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
Sahay P; Hyderabad Eye Research Foundation (HERF), L.V. Prasad Eye Institute, Bhubaneswar 751024, India.; School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
Rao A; Hyderabad Eye Research Foundation (HERF), L.V. Prasad Eye Institute, Bhubaneswar 751024, India.; School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
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Źródło:
Cells [Cells] 2021 Dec 07; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Exfoliation Syndrome/*genetics
Protein Aggregates/*genetics
Trabecular Meshwork/*metabolism
Transforming Growth Factor beta1/*pharmacology
Amyloid beta-Peptides/adverse effects ; Amyloid beta-Peptides/genetics ; Cell Survival/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Exfoliation Syndrome/complications ; Exfoliation Syndrome/pathology ; Gene Expression Regulation/drug effects ; Glaucoma/complications ; Glaucoma/genetics ; Glaucoma/pathology ; Humans ; Primary Cell Culture/methods ; Protein Aggregates/drug effects ; Trabecular Meshwork/pathology ; Transforming Growth Factor beta1/genetics
Czasopismo naukowe
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Wyświetlanie 1-20 z 2942

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