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Tytuł:
EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms.
Autorzy:
Li L; Immune Mechanism and Therapy of Major Diseases of Luzhou Key Laboratory, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.
Zhang D; Department of Traditional Chinese Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Cao X; Immune Mechanism and Therapy of Major Diseases of Luzhou Key Laboratory, School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.
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Źródło:
Frontiers in immunology [Front Immunol] 2024 Jan 22; Vol. 15, pp. 1320689. Date of Electronic Publication: 2024 Jan 22 (Print Publication: 2024).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hematologic Neoplasms*/genetics
Hematologic Neoplasms*/metabolism
Neoplasms*/metabolism
PAX5 Transcription Factor*/genetics
PAX5 Transcription Factor*/metabolism
Trans-Activators*/genetics
Trans-Activators*/metabolism
Proto-Oncogene Proteins c-myc*/genetics
Proto-Oncogene Proteins c-myc*/metabolism
Humans ; B-Lymphocytes ; Receptors, Antigen/metabolism
Czasopismo naukowe
Tytuł:
Synthetic Homoserine Lactone Sensors for Gram-Positive Bacillus subtilis Using LuxR-Type Regulators.
Autorzy:
Zeng M; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Sarker B; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Howitz N; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Shah I; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Andrews LB; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.; Biotechnology Training Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
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Źródło:
ACS synthetic biology [ACS Synth Biol] 2024 Jan 19; Vol. 13 (1), pp. 282-299. Date of Electronic Publication: 2023 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
Trans-Activators*/genetics
Trans-Activators*/metabolism
Repressor Proteins*/metabolism
Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; 4-Butyrolactone/metabolism ; Quorum Sensing/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial/genetics ; Homoserine/metabolism
Czasopismo naukowe
Tytuł:
Matrix Nonlinear Viscoelasticity Regulates Skeletal Myogenesis through MRTF Nuclear Localization and Nuclear Mechanotransduction.
Autorzy:
Shi N; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Wang J; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Tang S; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Zhang H; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, P. R. China.
Wei Z; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Li A; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology, Xi'an Jiaotong University, Xi'an, 710004, P. R. China.
Ma Y; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Xu F; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
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Źródło:
Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Mar; Vol. 20 (9), pp. e2305218. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Transcription Factors*
Mechanotransduction, Cellular*
Nuclear Proteins*
Trans-Activators*
Animals ; Mice ; Muscle, Skeletal ; Muscle Development ; Collagen
Czasopismo naukowe
Tytuł:
Identifying LasR Quorum Sensors with Improved Signal Specificity by Mapping the Sequence-Function Landscape.
Autorzy:
Zeng M; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Sarker B; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Rondthaler SN; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Vu V; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Andrews LB; Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.; Biotechnology Training Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
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Źródło:
ACS synthetic biology [ACS Synth Biol] 2024 Feb 16; Vol. 13 (2), pp. 568-589. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Trans-Activators*/metabolism
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Signal Transduction ; Pseudomonas aeruginosa/metabolism ; Mutation ; Quorum Sensing/genetics ; 4-Butyrolactone/metabolism ; Gene Expression Regulation, Bacterial
Czasopismo naukowe
Tytuł:
The protein phosphatase EYA4 promotes homologous recombination (HR) through dephosphorylation of tyrosine 315 on RAD51.
Autorzy:
de la Peña Avalos B; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Mays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, TX, USA.
Paquet N; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Tropée R; Queensland University of Technology, Translational Research Institute, Brisbane, QLD, Australia.
Coulombe Y; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Québec City, QC, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Québec City, QC, Canada.
Palacios H; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Leung JW; Department of Radiation Oncology, University of Texas Health and Science Center, San Antonio, TX 78229, USA.
Masson JY; Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division, Québec City, QC, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Québec City, QC, Canada.
Duijf PHG; Centre for Cancer Biology, Clinical and Health Sciences, University of South Australia & SA Pathology, Adelaide SA, Australia.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Dray E; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Mays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2024 Feb 09; Vol. 52 (3), pp. 1173-1187.
Typ publikacji:
Journal Article
MeSH Terms:
Rad51 Recombinase*/genetics
Rad51 Recombinase*/metabolism
Trans-Activators*/metabolism
DNA ; DNA Repair ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Homologous Recombination/genetics ; Phosphoprotein Phosphatases/metabolism ; Tyrosine/genetics ; Humans
Czasopismo naukowe
Tytuł:
Epithelioid hemangioendothelioma (EHE) with WWTR1::TFE3 gene fusion, a novel fusion variant.
Autorzy:
Li S; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Dermawan JK; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Seavey CN; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Molecular Medicine, PRISM Program, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Ma S; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Antonescu CR; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Rubin BP; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
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Źródło:
Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2024 Feb; Vol. 63 (2), pp. e23226.
Typ publikacji:
Journal Article
MeSH Terms:
Trans-Activators*/genetics
Hemangioendothelioma, Epithelioid*/genetics
Hemangioendothelioma, Epithelioid*/pathology
Humans ; Mice ; Animals ; NIH 3T3 Cells ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Gene Fusion ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins
Czasopismo naukowe
Tytuł:
Unlocking β-cell restoration: The crucial role of PDX1 in diabetes therapy.
Autorzy:
Siwan D; Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi 110017, India.
Nandave M; Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi 110017, India. Electronic address: .
Gilhotra R; School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India.
Almalki WH; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Gupta G; Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, Ajman, 346, United Arab Emirates.
Gautam RK; Department of Pharmacology, Indore Institute of Pharmacy, IIST Campus, Opposite IIM Indore, Rau-Pithampur Road, Indore 453331, Madhya Pradesh, India.
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Źródło:
Pathology, research and practice [Pathol Res Pract] 2024 Feb; Vol. 254, pp. 155131. Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Diabetes Mellitus*/therapy
Diabetes Mellitus*/metabolism
Homeodomain Proteins*/metabolism
Insulin-Secreting Cells*/metabolism
Trans-Activators*/metabolism
Humans ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Disease-associated AIOLOS variants lead to immune deficiency/dysregulation by haploinsufficiency and redefine AIOLOS functional domains.
Autorzy:
Kuehn HS; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Sakovich IS; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Niemela JE; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Gil Silva AA; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Stoddard JL; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Polyakova EA; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Esteve Sole A; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Aleshkevich SN; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Uglova TA; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Belevtsev MV; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Vertelko VR; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Shman TV; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Kupchinskaya AN; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Walter JE; Division of Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.; Division of Allergy and Immunology, Department of Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.; Division of Pediatric Allergy and Immunology, Massachusetts General Hospital for Children, Boston, Massachusetts, USA.
Fleisher TA; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy of Infectious Diseases, NIH, Bethesda, Maryland, USA.
Peng XP; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Delmonte OM; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy of Infectious Diseases, NIH, Bethesda, Maryland, USA.
Sharapova SO; Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Rosenzweig SD; Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
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Źródło:
The Journal of clinical investigation [J Clin Invest] 2024 Feb 01; Vol. 134 (3). Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Haploinsufficiency*
Trans-Activators*/metabolism
Humans ; DNA ; Gene Expression Regulation ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł:
The interplay between cis- and trans-acting factors drives selective mRNA translation initiation in eukaryotes.
Autorzy:
Tidu A; Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, Architecture et Réactivité de l'ARN, CNRS UPR9002, 2, allée Konrad Roentgen, F-67084 Strasbourg, France.
Martin F; Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, Architecture et Réactivité de l'ARN, CNRS UPR9002, 2, allée Konrad Roentgen, F-67084 Strasbourg, France. Electronic address: .
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Źródło:
Biochimie [Biochimie] 2024 Feb; Vol. 217, pp. 20-30. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Eukaryota*/genetics
Trans-Activators*/metabolism
Codon, Initiator/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Proteome/metabolism ; Peptide Chain Initiation, Translational ; Codon ; Protein Biosynthesis ; Open Reading Frames/genetics ; 5' Untranslated Regions/genetics
Czasopismo naukowe
Tytuł:
Directed Evolution of 4-Hydroxyphenylpyruvate Biosensors Based on a Dual Selection System.
Autorzy:
Du H; School of Life Science, Northeast Forestry University, Harbin 150040, China.; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.; Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China.
Liang Y; School of Life Science, Northeast Forestry University, Harbin 150040, China.; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.; Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China.
Li J; School of Life Science, Northeast Forestry University, Harbin 150040, China.; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.
Yuan X; School of Life Science, Northeast Forestry University, Harbin 150040, China.; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.
Tao F; School of Life Science, Northeast Forestry University, Harbin 150040, China.; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.
Dong C; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.; Aulin College, Northeast Forestry University, Harbin 150040, China.
Shen Z; School of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
Sui G; School of Life Science, Northeast Forestry University, Harbin 150040, China.; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.; Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China.; Aulin College, Northeast Forestry University, Harbin 150040, China.
Wang P; School of Life Science, Northeast Forestry University, Harbin 150040, China.; NEFU-China iGEM Team, Northeast Forestry University, Harbin 150040, China.; Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China.; Aulin College, Northeast Forestry University, Harbin 150040, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Trans-Activators*/metabolism
Biosensing Techniques*
Phenylpyruvic Acids*
Escherichia coli/genetics ; Escherichia coli/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development.
Autorzy:
Collins JM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lang A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Parisi C; Department of Bioengineering, Imperial College London, London, UK.
Moharrer Y; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Mechanical Engineering, University of Pennsylvania, Philadelphia, PA, USA.
Nijsure MP; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Thomas Kim JH; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ahmed S; Department of Bioengineering, Imperial College London, London, UK.
Szeto GL; Seagen, Bothell, WA, USA.
Qin L; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Gottardi R; Department of Pediatrics, Division of Pulmonary Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Dyment NA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nowlan NC; Department of Bioengineering, Imperial College London, London, UK; School of Mechanical and Materials Engineering, University College Dublin, Dublin, Ireland; UCD Conway Institute, University College Dublin, Dublin, Ireland.
Boerckel JD; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: .
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Źródło:
Developmental cell [Dev Cell] 2024 Jan 22; Vol. 59 (2), pp. 211-227.e5. Date of Electronic Publication: 2023 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Adaptor Proteins, Signal Transducing*/metabolism
Trans-Activators*/metabolism
Animals ; Humans ; Mice ; Angiogenesis ; Bone Development ; Morphogenesis ; Osteoblasts/metabolism ; Transcription Factors/metabolism ; YAP-Signaling Proteins
Czasopismo naukowe
Tytuł:
Line Shape Analysis of F NMR-Monitored Chemical Denaturation of a Fold-Switching Protein RfaH Reveals Its Slow Folding Dynamics.
Autorzy:
Bhuvaneshwari RA; Department of Chemistry, IIT Bombay, Powai, Mumbai 400076, India.
Shivamani A; Department of Chemistry, IIT Bombay, Powai, Mumbai 400076, India.
Sengupta I; Department of Chemistry, IIT Bombay, Powai, Mumbai 400076, India.
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Źródło:
The journal of physical chemistry. B [J Phys Chem B] 2024 Jan 18; Vol. 128 (2), pp. 465-471. Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Trans-Activators*/chemistry
Escherichia coli Proteins*/chemistry
Protein Structure, Tertiary ; Peptide Elongation Factors/chemistry ; Transcription Factors/chemistry ; Protein Folding ; Protein Denaturation
Czasopismo naukowe
Tytuł:
Transcription factor interactions explain the context-dependent activity of CRX binding sites.
Autorzy:
Loell KJ; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.; The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
Friedman RZ; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.; The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
Myers CA; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
Corbo JC; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
Cohen BA; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.; The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
White MA; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.; The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2024 Jan 16; Vol. 20 (1), pp. e1011802. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Transcription Factors*/metabolism
Trans-Activators*/metabolism
Homeodomain Proteins/genetics ; Gene Expression Regulation ; Binding Sites/genetics ; Retina
Czasopismo naukowe
Tytuł:
Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway.
Autorzy:
Grote A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Piscon B; Infectious Diseases Research Laboratory, Sheba Medical Center, Tel-Hashomer, Israel; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Manson AL; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Adani B; Infectious Diseases Research Laboratory, Sheba Medical Center, Tel-Hashomer, Israel.
Cohen H; Infectious Diseases Research Laboratory, Sheba Medical Center, Tel-Hashomer, Israel.
Livny J; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: .
Earl AM; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: .
Gal-Mor O; Infectious Diseases Research Laboratory, Sheba Medical Center, Tel-Hashomer, Israel; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: .
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Źródło:
Cell host & microbe [Cell Host Microbe] 2024 Jan 10; Vol. 32 (1), pp. 79-92.e7.
Typ publikacji:
Journal Article
MeSH Terms:
Trans-Activators*/metabolism
Salmonella Infections*/microbiology
Animals ; Mice ; Humans ; Persistent Infection ; Salmonella typhimurium ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Mutation ; Gene Expression Regulation, Bacterial
Czasopismo naukowe
Tytuł:
Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys.
Autorzy:
Chang YT; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Lee YJ; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Haque M; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Chang HC; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Javed S; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Lin YC; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Cho Y; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Abramovitz J; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Chin G; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Khamis A; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Raja R; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Murai KK; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Huang WH; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, McGill University, Montréal, Québec, Canada.; Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
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Źródło:
The Journal of comparative neurology [J Comp Neurol] 2024 Jan; Vol. 532 (1), pp. e25589.
Typ publikacji:
Journal Article
MeSH Terms:
Autism Spectrum Disorder*/genetics
Smith-Magenis Syndrome*
Trans-Activators*/genetics
Animals ; Mice ; Callithrix ; GABAergic Neurons ; High Mobility Group Proteins ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł:
Roles and signaling pathways of CITED1 in tumors: overview and novel insights.
Autorzy:
Chen W; Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.; The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.
Jiang J; Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.; The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.
Gao J; Department of Intervention, The Second Hospital Affiliated to Dalian Medical University, Dalian, China.
Wang G; Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Wang R; Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.; The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.
Lv J; Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Ben J; Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
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Źródło:
The Journal of international medical research [J Int Med Res] 2024 Jan; Vol. 52 (1), pp. 3000605231220890.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/genetics
Apoptosis Regulatory Proteins*/genetics
Trans-Activators*/genetics
Humans ; Estrogens ; Transcription Factors
Czasopismo naukowe
Tytuł:
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation.
Autorzy:
Guo Y; Peking University Health Science Center, School of Basic Medical Sciences, Beijing, 100191, China. .; Peking University Institute of Cardiovascular Sciences, Beijing, 100191, China. .; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China. .; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China. .
Cao Y; Boston Children's Hospital, Department of Cardiology, Boston, MA, 02115, USA.
Jardin BD; Boston Children's Hospital, Department of Cardiology, Boston, MA, 02115, USA.
Mazumdar N; Boston Children's Hospital, Department of Cardiology, Boston, MA, 02115, USA.
Guo C; Peking University Health Science Center, School of Basic Medical Sciences, Beijing, 100191, China.; Peking University Institute of Cardiovascular Sciences, Beijing, 100191, China.
Yang L; Peking University Health Science Center, School of Basic Medical Sciences, Beijing, 100191, China.; Peking University Institute of Cardiovascular Sciences, Beijing, 100191, China.
Lin J; Peking University Health Science Center, School of Basic Medical Sciences, Beijing, 100191, China.; Peking University Institute of Cardiovascular Sciences, Beijing, 100191, China.
Chen Z; Peking University Health Science Center, School of Basic Medical Sciences, Beijing, 100191, China.; Peking University Institute of Cardiovascular Sciences, Beijing, 100191, China.
Ma Q; Boston Children's Hospital, Department of Cardiology, Boston, MA, 02115, USA.
Zhao M; Peking University Third Hospital, Department of Cardiology and Institute of Vascular Medicine, Beijing, 100191, China.; Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, Haihe Laboratory of Cell Ecosystem, Beijing, 100191, China.
Dong E; Peking University Institute of Cardiovascular Sciences, Beijing, 100191, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China.; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China.; Peking University Third Hospital, Department of Cardiology and Institute of Vascular Medicine, Beijing, 100191, China.; Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, Haihe Laboratory of Cell Ecosystem, Beijing, 100191, China.; National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, 100191, China.
Pu WT; Boston Children's Hospital, Department of Cardiology, Boston, MA, 02115, USA. .; Harvard Stem Cell Institute, Cambridge, MA, 02138, USA. .
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Źródło:
Science China. Life sciences [Sci China Life Sci] 2023 Dec; Vol. 66 (12), pp. 2939-2942. Date of Electronic Publication: 2023 Aug 11.
Typ publikacji:
Letter
MeSH Terms:
Myocytes, Cardiac*/metabolism
Trans-Activators*/genetics
Trans-Activators*/metabolism
Transcription Factors/genetics ; Nuclear Proteins/genetics ; Transcriptional Activation
Opinia redakcyjna
Tytuł:
POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target.
Autorzy:
Jing T; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.
Xu X; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.
Wu C; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.
Wei D; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.
Yuan L; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.
Huang Y; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.
Liu Y; Department of Medical Oncology, Fudan University Shanghai Cancer Center, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address: .
Wang B; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2023 Nov 28; Vol. 577, pp. 216444. Date of Electronic Publication: 2023 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Pancreatic Ductal*/pathology
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/metabolism
Trans-Activators*/antagonists & inhibitors
Trans-Activators*/metabolism
Proteasome Endopeptidase Complex*/metabolism
Animals ; Humans ; Mice ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Metaplasia/pathology ; Pancreas/pathology ; Pancreatic Neoplasms
Czasopismo naukowe
Tytuł:
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms.
Autorzy:
Zheng Y; Molecular Genetic and Genomics Graduate Program, Division of Biological and Biomedical Sciences, Washington University in St Louis, Saint Louis, United States.; Department of Ophthalmology and Visual Sciences, Washington University in St Louis, Saint Louis, United States.
Sun C; Molecular Genetic and Genomics Graduate Program, Division of Biological and Biomedical Sciences, Washington University in St Louis, Saint Louis, United States.; Department of Ophthalmology and Visual Sciences, Washington University in St Louis, Saint Louis, United States.
Zhang X; Department of Ophthalmology and Visual Sciences, Washington University in St Louis, Saint Louis, United States.
Ruzycki PA; Department of Ophthalmology and Visual Sciences, Washington University in St Louis, Saint Louis, United States.; Department of Genetics, Washington University in St Louis, Saint Louis, United States.
Chen S; Molecular Genetic and Genomics Graduate Program, Division of Biological and Biomedical Sciences, Washington University in St Louis, Saint Louis, United States.; Department of Ophthalmology and Visual Sciences, Washington University in St Louis, Saint Louis, United States.; Department of Developmental Biology, Washington University in St Louis, Saint Louis, United States.
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Źródło:
ELife [Elife] 2023 Nov 14; Vol. 12. Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:
Journal Article
MeSH Terms:
Retinal Diseases*/pathology
Trans-Activators*/genetics
Trans-Activators*/metabolism
Animals ; Humans ; Mice ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Mutation, Missense ; Retina/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity.
Autorzy:
Sberna S; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
Lopez-Hernandez A; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
Biancotto C; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
Motta L; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
Andronache A; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
Verhoef LGGC; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
Caganova M; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
Campaner S; Center for Genomic Science of IIT, (Istituto Italiano di Tecnologia at European School of Molecular Medicine), Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy.
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Źródło:
Cells [Cells] 2023 Oct 11; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Trans-Activators*/genetics
Trans-Activators*/metabolism
Neoplasms*
Humans ; YAP-Signaling Proteins ; Intracellular Signaling Peptides and Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Wnt Signaling Pathway ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; Deubiquitinating Enzymes/metabolism
Czasopismo naukowe

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