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Wyszukujesz frazę ""Transcription, Genetic"" wg kryterium: Temat


Tytuł :
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders.
Autorzy :
Jia N; Department of Allergy and Clinical Immunology, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Guo C; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Nakazawa Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
van den Heuvel D; Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Luijsterburg MS; Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands. Electronic address: .
Ogi T; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan; Department of Human Genetics and Molecular Biology, Graduate School of Medicine, Nagoya University, Nagoya, Japan. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Oct; Vol. 106, pp. 103192. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Damage*
DNA Repair*
Genomic Instability*
Transcription, Genetic*
RNA Polymerase II/*metabolism
Aging ; Animals ; DNA/metabolism ; Eukaryota/enzymology ; Eukaryota/genetics ; Eukaryota/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Defining R-loop classes and their contributions to genome instability.
Autorzy :
Castillo-Guzman D; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA, 95616, United States.
Chédin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA, 95616, United States. Electronic address: .
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Źródło :
DNA repair [DNA Repair (Amst)] 2021 Oct; Vol. 106, pp. 103182. Date of Electronic Publication: 2021 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Genomic Instability*
R-Loop Structures*
Transcription, Genetic*
Animals ; Eukaryota/genetics ; Eukaryota/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse.
Autorzy :
Hoang AC; Institute of Neurobiology, Ulm University, 89081 Ulm, Germany.
Yu H; Institute of Neurobiology, Ulm University, 89081 Ulm, Germany.
Röszer T; Institute of Neurobiology, Ulm University, 89081 Ulm, Germany.
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Źródło :
Cells [Cells] 2021 Sep 09; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Adipocytes, Beige/*metabolism
Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Animals ; Animals, Newborn ; Biomarkers/metabolism ; Cell Cycle/genetics ; Gene Expression Regulation, Developmental ; Gene Ontology ; Gene Regulatory Networks ; Male ; Mice, Inbred C57BL ; Models, Biological ; Muscle Development/genetics ; Neuropeptides/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines.
Autorzy :
Ramirez R; Gilead Sciences Inc., Foster City, California, USA.
van Buuren N; Gilead Sciences Inc., Foster City, California, USA.
Gamelin L; Gilead Sciences Inc., Foster City, California, USA.
Soulette C; Gilead Sciences Inc., Foster City, California, USA.
May L; Gilead Sciences Inc., Foster City, California, USA.
Han D; Gilead Sciences Inc., Foster City, California, USA.
Yu M; Gilead Sciences Inc., Foster City, California, USA.
Choy R; Gilead Sciences Inc., Foster City, California, USA.
Cheng G; Gilead Sciences Inc., Foster City, California, USA.
Bhardwaj N; Gilead Sciences Inc., Foster City, California, USA.
Chiu J; Gilead Sciences Inc., Foster City, California, USA.
Muench RC; Gilead Sciences Inc., Foster City, California, USA.
Delaney WE 4th; Gilead Sciences Inc., Foster City, California, USA.
Mo H; Gilead Sciences Inc., Foster City, California, USA.
Feierbach B; Gilead Sciences Inc., Foster City, California, USA.
Li L; Gilead Sciences Inc., Foster City, California, USA.
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Źródło :
Journal of virology [J Virol] 2021 Sep 09; Vol. 95 (19), pp. e0029921. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Line, Tumor*
Transcription, Genetic*
Translocation, Genetic*
Virus Integration*
Carcinoma, Hepatocellular/*virology
DNA, Viral/*genetics
Hepatitis B virus/*genetics
Hepatitis B virus/*physiology
Humans ; Sequence Analysis, DNA ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Development of a Novel In Vitro Primary Human Monocyte-Derived Macrophage Model To Study Reactivation of HIV-1 Transcription.
Autorzy :
Wong ME; Life Sciences Discipline, Burnet Institute, Melbourne, Australia.; Department of Immunology, Central Clinical School, Monash University, Melbourne, Australia.
Johnson CJ; Bioimaging Platform, La Trobe University, Melbourne, Australia.
Hearps AC; Life Sciences Discipline, Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases, Monash University, Melbourne, Australia.
Jaworowski A; Department of Infectious Diseases, Monash University, Melbourne, Australia.; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
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Źródło :
Journal of virology [J Virol] 2021 Sep 09; Vol. 95 (19), pp. e0022721. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Virus Activation*
HIV-1/*genetics
HIV-1/*physiology
Macrophages/*virology
Bryostatins/pharmacology ; Cytokines/pharmacology ; HIV-1/drug effects ; Humans ; Panobinostat/pharmacology ; T-Lymphocytes/virology ; Virus Latency ; Virus Replication ; Vorinostat/pharmacology
Czasopismo naukowe
Tytuł :
Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.
Autorzy :
Goel S; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Bhatia V; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Kundu S; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Biswas T; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Carskadon S; Vattikuti Urology Institute, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
Gupta N; Department of Pathology, Henry Ford Health System, Detroit, MI, USA.
Asim M; Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Morrissey C; Department of Urology, University of Washington, Seattle, WA, USA.
Palanisamy N; Vattikuti Urology Institute, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
Ateeq B; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India. .; The Mehta Family Center for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, U.P., India. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 07; Vol. 12 (1), pp. 5325. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcription, Genetic*
Homeodomain Proteins/*genetics
Prostatic Neoplasms/*genetics
Receptors, Androgen/*genetics
Transcription Factors/*genetics
Androgen Antagonists/pharmacology ; Animals ; Azepines/pharmacology ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, SCID ; Neoplasm Metastasis ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Promoter Regions, Genetic ; Prostate/drug effects ; Prostate/metabolism ; Prostate/pathology ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Protein Binding ; Receptors, Androgen/metabolism ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Signal Transduction ; Survival Analysis ; Transcription Factors/metabolism ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism ; Triazoles/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Regulation of HP1 protein by phosphorylation during transcriptional repression and cell cycle.
Autorzy :
Oki M; Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui-shi, Fukui 910-8507, Japan.
Masai H; Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
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Źródło :
Journal of biochemistry [J Biochem] 2021 Sep 07; Vol. 169 (6), pp. 629-632.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle*
Transcription, Genetic*
Chromosomal Proteins, Non-Histone/*metabolism
Heterochromatin/*metabolism
Histones/*metabolism
Chromosomal Proteins, Non-Histone/genetics ; Heterochromatin/genetics ; Histones/genetics ; Humans ; Phosphorylation ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis.
Autorzy :
Zhang X; School of Basic Medical Sciences, Beijing Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Peng L; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Luo Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang S; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Pu Y; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Guo W; Cancer Institute, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China.; Key Laboratory of Oncology of Xinjiang Uyghur Autonomous Regio, Urumqi, China.
Yao J; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
Shao M; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Fan W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cui Q; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xi Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Sun Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Niu X; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhao X; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen L; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Liu Y; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yang X; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang C; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhong C; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Tan W; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang J; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. .
Wu C; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. .; CAMS Oxford Institute (COI), Chinese Academy of Medical Sciences, Beijing, China. .; CAMS key Laboratory of Cancer Genomic Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .
Lin D; Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.; CAMS key Laboratory of Cancer Genomic Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China.
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Źródło :
Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5291. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Esophageal Neoplasms/*genetics
Esophageal Squamous Cell Carcinoma/*genetics
Neoplasm Proteins/*genetics
Stromal Cells/*immunology
Adult ; Aged ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Epithelial Cells/immunology ; Epithelial Cells/pathology ; Esophageal Neoplasms/immunology ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/immunology ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Female ; Fibroblasts/immunology ; Fibroblasts/pathology ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Myeloid Cells/immunology ; Myeloid Cells/pathology ; Neoplasm Proteins/classification ; Neoplasm Proteins/immunology ; Prognosis ; Single-Cell Analysis ; Stromal Cells/pathology ; Survival Analysis ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
The concurrence of DNA methylation and demethylation is associated with transcription regulation.
Autorzy :
Shi J; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Xu J; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Chen YE; Department of Statistics, University of California, Los Angeles, CA, USA.
Li JS; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Cui Y; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Shen L; Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.
Li JJ; Department of Statistics, University of California, Los Angeles, CA, USA.
Li W; Division of Computational Biomedicine, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5285. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Methylation*
Epigenesis, Genetic*
Genome*
Transcription, Genetic*
DNA Modification Methylases/*genetics
DNA-Binding Proteins/*genetics
Neoplasms/*genetics
Proto-Oncogene Proteins/*genetics
Animals ; Chromatin/chemistry ; Chromatin/metabolism ; CpG Islands ; DNA/genetics ; DNA/metabolism ; DNA Modification Methylases/metabolism ; DNA-Binding Proteins/metabolism ; Gene Ontology ; Histones/genetics ; Histones/metabolism ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Mice ; Molecular Sequence Annotation ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Proto-Oncogene Proteins/metabolism ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł :
MYC protein interactors in gene transcription and cancer.
Autorzy :
Lourenco C; Princess Margaret Cancer Centre, Toronto, ON, Canada.
Resetca D; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Redel C; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Lin P; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
MacDonald AS; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Ciaccio R; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Kenney TMG; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Wei Y; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Andrews DW; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Sunnerhagen M; Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.
Arrowsmith CH; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, Toronto, ON, Canada.
Raught B; Princess Margaret Cancer Centre, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Penn LZ; Princess Margaret Cancer Centre, Toronto, ON, Canada. .; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. .
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Źródło :
Nature reviews. Cancer [Nat Rev Cancer] 2021 Sep; Vol. 21 (9), pp. 579-591. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Transcription, Genetic*
Neoplasms/*metabolism
Oncogene Protein p55(v-myc)/*metabolism
Animals ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/genetics ; Oncogene Protein p55(v-myc)/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes.
Autorzy :
DasGupta S; Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
Nykiel K; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA.
Piccirilli JA; Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Sep; Vol. 27 (9), pp. 1017-1024. Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Inverted Repeat Sequences*
Transcription, Genetic*
DNA/*genetics
RNA, Catalytic/*metabolism
Base Pairing ; Biocatalysis ; Cell-Free System ; DNA/metabolism ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Nucleic Acid Conformation ; Nucleotide Motifs ; Phosphorus Radioisotopes ; Point Mutation ; RNA, Catalytic/chemistry ; RNA, Catalytic/genetics ; Viral Proteins/genetics ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
An NF-κB-responsive long noncoding RNA, PINT, regulates TNF-α gene transcription by scaffolding p65 and EZH2.
Autorzy :
Ye M; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.; Department of Research, Tumor Hospital of Guangxi Medical University, Nanning, P. R. China.
Wang C; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.
Zhu J; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.
Chen M; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, P. R. China.
Wang S; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.
Li M; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.
Lu Y; Department of Endocrinology, Institute of geriatric medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Xiao P; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.
Zhou M; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.
Li X; Center for Stem Cell Research and Application, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, P. R. China.
Zhou R; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan University, Wuhan, P. R. China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21667.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Transcription, Genetic*/genetics
Enhancer of Zeste Homolog 2 Protein/*metabolism
RNA, Long Noncoding/*genetics
Transcription Factor RelA/*metabolism
Tumor Necrosis Factor-alpha/*genetics
Animals ; Cell Line ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/pathology ; Cytokines/genetics ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/pathology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Promoter Regions, Genetic/genetics ; Protein Binding
Czasopismo naukowe
Tytuł :
Poacic acid, a β-1,3-glucan-binding antifungal agent, inhibits cell-wall remodeling and activates transcriptional responses regulated by the cell-wall integrity and high-osmolarity glycerol pathways in yeast.
Autorzy :
García R; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, IRYCIS, Madrid, Spain.
Itto-Nakama K; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.
Rodríguez-Peña JM; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, IRYCIS, Madrid, Spain.
Chen X; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.
Sanz AB; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, IRYCIS, Madrid, Spain.
de Lorenzo A; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, IRYCIS, Madrid, Spain.
Pavón-Vergés M; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, IRYCIS, Madrid, Spain.
Kubo K; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.
Ohnuki S; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.
Nombela C; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, IRYCIS, Madrid, Spain.
Popolo L; Department of Biosciences, University of Milan, Milan, Italy.
Ohya Y; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan.; Collaborative Research Institute for Innovative Microbiology (CRIIM), The University of Tokyo, Tokyo, Japan.
Arroyo J; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, IRYCIS, Madrid, Spain.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21778.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antifungal Agents/*pharmacology
Cell Wall/*drug effects
Coumaric Acids/*pharmacology
Glycerol/*metabolism
Saccharomyces cerevisiae/*drug effects
Stilbenes/*pharmacology
Transcription, Genetic/*drug effects
beta-Glucans/*pharmacology
Caspofungin/pharmacology ; Cell Wall/genetics ; Cell Wall/metabolism ; Chitin/pharmacology ; Echinocandins/pharmacology ; Fungal Proteins/genetics ; Gene Expression Regulation, Fungal/drug effects ; Gene Expression Regulation, Fungal/genetics ; Osmolar Concentration ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Sex chromosome degeneration, turnover, and sex-biased expression of sex-linked transcripts in African clawed frogs ( Xenopus ).
Autorzy :
Song XY; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.
Furman BLS; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.; Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, Canada V6T 1Z4.
Premachandra T; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.
Knytl M; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.; Department of Cell Biology, Charles University, 7 Vinicna Street, Prague 12843, Czech Republic.
Cauret CMS; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.
Wasonga DV; National Museums of Kenya, PO Box 40658 - GPO 00100, Nairobi, Kenya.
Measey J; Centre for Invasion Biology, Department of Botany and Zoology, Stellenbosch University, Private Bag X1, Matieland, 7602 Stellenbosch, South Africa.
Dworkin I; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.
Evans BJ; Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.
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Źródło :
Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2021 Aug 30; Vol. 376 (1832), pp. 20200095. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sex Determination Processes*
Transcription, Genetic*
Sex Chromosomes/*genetics
Xenopus/*genetics
Animals ; Female ; Male ; Sex Characteristics
Czasopismo naukowe
Tytuł :
CTCF and transcription influence chromatin structure re-configuration after mitosis.
Autorzy :
Zhang H; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China. .; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. .
Lam J; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zhang D; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lan Y; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vermunt MW; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Keller CA; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
Giardine B; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
Hardison RC; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
Blobel GA; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. .; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 27; Vol. 12 (1), pp. 5157. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Mitosis*
Transcription, Genetic*
CCCTC-Binding Factor/*metabolism
Chromatin/*metabolism
Animals ; CCCTC-Binding Factor/genetics ; Cell Division ; Cell Line ; Chromatin/genetics ; Chromatin Assembly and Disassembly ; Enhancer Elements, Genetic ; Mice ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Plasmid replication based on the T7 origin of replication requires a T7 RNAP variant and inactivation of ribonuclease H.
Autorzy :
Becker K; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland.
Meyer A; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland.; FGen GmbH, Basel 4057, Switzerland.
Roberts TM; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland.
Panke S; Department of Biosystems Science and Engineering, ETH Zurich, Basel 4058, Switzerland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Aug 20; Vol. 49 (14), pp. 8189-8198.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
DNA Replication/*genetics
DNA-Directed RNA Polymerases/*genetics
Ribonuclease H/*genetics
Viral Proteins/*genetics
Bacteriophage T7/genetics ; Escherichia coli/genetics ; Genetic Engineering ; Plasmids/genetics ; Replication Origin/genetics ; Synthetic Biology
Czasopismo naukowe
Tytuł :
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes.
Autorzy :
Shoaib M; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Biology, SBA School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan.
Chen Q; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Shi X; School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.
Nair N; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Prasanna C; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Yang R; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.; Wilmar International Limited, Jurong Island, Singapore.
Walter D; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Frederiksen KS; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
Einarsson H; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Svensson JP; Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
Liu CF; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Ekwall K; Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
Lerdrup M; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. .
Nordenskiöld L; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. .
Sørensen CS; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 20; Vol. 12 (1), pp. 4800. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, Essential*
Transcription, Genetic*
Chromatin/*metabolism
Histones/*metabolism
Lysine/*metabolism
Amino Acid Sequence ; Animals ; Cell Cycle/genetics ; Cell Line ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/chemistry ; Humans ; Magnetic Resonance Spectroscopy ; Methylation ; Mice ; Models, Biological ; Nucleosomes/metabolism ; Protein Conformation
Czasopismo naukowe
Tytuł :
A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions.
Autorzy :
Desai RV; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program and Tetrad Graduate Program, University of California, San Francisco, CA 94158, USA.
Chen X; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.
Martin B; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.; Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, the Netherlands.
Chaturvedi S; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.
Hwang DW; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Li W; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Yu C; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
Ding S; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Thomson M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Singer RH; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Coleman RA; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hansen MMK; Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, the Netherlands.
Weinberger LS; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA. .; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Aug 20; Vol. 373 (6557). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Cellular Reprogramming*
DNA Repair*
Gene Expression*/drug effects
Transcription, Genetic*/drug effects
DNA/*chemistry
DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism
Animals ; Cells, Cultured ; Computer Simulation ; DNA/genetics ; DNA/metabolism ; Embryonic Stem Cells ; Idoxuridine/metabolism ; Idoxuridine/pharmacology ; Mice ; Models, Genetic ; Nanog Homeobox Protein/genetics ; Nucleic Acid Conformation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Single-Cell Analysis ; Stochastic Processes ; Thymidine Kinase/genetics ; Thymidine Kinase/metabolism
Czasopismo naukowe
Tytuł :
Local states of chromatin compaction at transcription start sites control transcription levels.
Autorzy :
Ishihara S; Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Sasagawa Y; Laboratory for Bioinformatics Research, RIKEN Center for Biosystems Dynamics Research, Wako, Saitama 351-0198, Japan.; Functional Genome Informatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.
Kameda T; Laboratory for Bioinformatics Research, RIKEN Center for Biosystems Dynamics Research, Wako, Saitama 351-0198, Japan.; Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526, Japan.
Yamashita H; Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan.
Umeda M; Laboratory for Bioinformatics Research, RIKEN Center for Biosystems Dynamics Research, Wako, Saitama 351-0198, Japan.
Kotomura N; Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Abe M; Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan.
Shimono Y; Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Nikaido I; Laboratory for Bioinformatics Research, RIKEN Center for Biosystems Dynamics Research, Wako, Saitama 351-0198, Japan.; Functional Genome Informatics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.; Master's/Doctoral Program in Life Science Innovation (Bioinformatics), Degree Programs in Systems and Information Engineering, Graduate School of Science and Technology, University of Tsukuba, Wako, Saitama 351-0198, Japan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Aug 20; Vol. 49 (14), pp. 8007-8023.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Initiation Site*
Transcription, Genetic*
Chromatin/*ultrastructure
Nucleosomes/*genetics
Centrifugation ; Chromatin/genetics ; Chromatin Assembly and Disassembly/genetics ; Genome, Human/genetics ; Histones/genetics ; Humans ; Nucleosomes/ultrastructure ; Protein Binding/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
m A RNA methylation regulates promoter- proximal pausing of RNA polymerase II.
Autorzy :
Akhtar J; Institute of Developmental Biology and Neurobiology, University of Mainz, 55128 Mainz, Germany. Electronic address: .
Renaud Y; Université Clermont Auvergne, CNRS UMR6293, Inserm U1103, GReD institute, 63000 Clermont-Ferrand, France.
Albrecht S; Faculty of Biology, Johannes Gutenberg University Mainz, Hans-Dieter-Hüsch-Weg 15, 55128 Mainz, Germany.
Ghavi-Helm Y; Institut de Génomique Fonctionnelle de Lyon, Univ Lyon, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.
Roignant JY; Center for Integrative Genomics, Génopode Building, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
Silies M; Institute of Developmental Biology and Neurobiology, University of Mainz, 55128 Mainz, Germany.
Junion G; Université Clermont Auvergne, CNRS UMR6293, Inserm U1103, GReD institute, 63000 Clermont-Ferrand, France. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Aug 19; Vol. 81 (16), pp. 3356-3367.e6. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Drosophila Proteins/*genetics
Multiprotein Complexes/*genetics
Nuclear Proteins/*genetics
RNA Polymerase II/*genetics
Animals ; Drosophila melanogaster/genetics ; Methyltransferases/genetics ; Promoter Regions, Genetic/genetics
Czasopismo naukowe

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