Information

Dear user, the application need JavaScript support. Please enable JavaScript in your browser.

You are browsing as a GUEST

You search for a phrase ""Transcription, Genetic"" according to the criterion: Subject Terms


Title :
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Authors :
Kirsch K; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Zeke A; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Tőke O; Laboratory for NMR Spectroscopy, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Sok P; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Sethi A; Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.
Sebő A; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Kumar GS; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
Egri P; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Póti ÁL; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Gooley P; Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3010, Australia.
Peti W; Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
Bento I; European Molecular Biology Laboratory, Hamburg, Germany.
Alexa A; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary.
Reményi A; Biomolecular Interactions Research Group, Institute of Organic Chemistry, Research Center for Natural Sciences, H-1117, Budapest, Hungary. .
Show more
Source :
Nature communications [Nat Commun] 2020 Nov 13; Vol. 11 (1), pp. 5769. Date of Electronic Publication: 2020 Nov 13.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Transcription, Genetic*
Activating Transcription Factor 2/*metabolism
JNK Mitogen-Activated Protein Kinases/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Activating Transcription Factor 2/chemistry ; Amino Acid Motifs ; Amino Acid Sequence ; HEK293 Cells ; Humans ; Luciferases/metabolism ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Phosphorylation ; Protein Binding ; Zinc Fingers
Academic Journal
Title :
Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males.
Authors :
Wei KH; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Gibilisco L; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Bachtrog D; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA. .
Show more
Source :
Nature communications [Nat Commun] 2020 Nov 02; Vol. 11 (1), pp. 5537. Date of Electronic Publication: 2020 Nov 02.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Silencing*
Transcription, Genetic*
DNA Transposable Elements/*genetics
Drosophila/*genetics
Y Chromosome/*metabolism
Animals ; Female ; Heterochromatin/metabolism ; Linear Models ; Male ; Models, Genetic ; Mutation ; Sex Factors ; Zygote
Academic Journal
Title :
Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation.
Authors :
Hu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. .
Zhong J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Xiao Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Xing Z; Earth, Planetary and Space Sciences, UCLA, Los Angeles, CA, USA.
Sheu K; Medical Scientist Training Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Fan S; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
An Q; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Qiu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Zheng Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Liu X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Fan G; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Liu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. .
Show more
Source :
Nature communications [Nat Commun] 2020 Oct 13; Vol. 11 (1), pp. 5148. Date of Electronic Publication: 2020 Oct 13.
Publication Type :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
RNA Caps/*genetics
RNA Isoforms/*genetics
Sequence Analysis, RNA/*methods
Humans ; Sequence Analysis, RNA/economics ; Single-Cell Analysis ; Species Specificity ; Transcription Initiation Site
Academic Journal
Title :
Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Authors :
Prigozhin DM; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Douse CH; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Farleigh LE; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Albecka A; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Tchasovnikarova IA; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Timms RT; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Oda SI; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Adolf F; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Freund SMV; NMR Facility, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Maslen S; Biological Mass Spectrometry & Proteomics Laboratory, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Lehner PJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Modis Y; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10313-10328.
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Antigens, Neoplasm/*ultrastructure
Nuclear Proteins/*ultrastructure
RNA-Binding Proteins/*chemistry
Antigens, Neoplasm/chemistry ; Antigens, Neoplasm/genetics ; Crystallography, X-Ray ; DNA Transposable Elements/genetics ; Epigenesis, Genetic/genetics ; Gene Silencing ; Humans ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Protein Aggregates/genetics ; Protein Binding/genetics ; Protein Conformation, alpha-Helical ; Protein Domains/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/ultrastructure ; Viruses/genetics
Academic Journal
Title :
NCBP3 positively impacts mRNA biogenesis.
Authors :
Dou Y; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Barbosa I; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
Jiang H; Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Iasillo C; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Molloy KR; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Schulze WM; European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9 38042, France.
Cusack S; European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9 38042, France.
Schmid M; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Le Hir H; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
LaCava J; Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.; European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen 9713 AV, Netherlands.
Jensen TH; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10413-10427.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
RNA/*genetics
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Active Transport, Cell Nucleus/genetics ; Cell Nucleus/genetics ; Exons ; Gene Expression Regulation/genetics ; Humans ; Nuclear Cap-Binding Protein Complex/genetics ; RNA Cap-Binding Proteins/genetics ; RNA Polymerase II/genetics ; RNA Stability/genetics ; RNA Transport/genetics ; Transcription Factors/genetics
Academic Journal
Title :
Replisome bypass of transcription complexes and R-loops.
Authors :
Brüning JG; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Marians KJ; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10353-10367.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transcription, Genetic*
DNA Replication/*genetics
DNA-Binding Proteins/*genetics
R-Loop Structures/*genetics
Base Composition/genetics ; Chromosome Structures/genetics ; Chromosomes/genetics ; DNA Helicases/genetics ; DNA Repair/genetics ; Escherichia coli/genetics ; Genomic Instability/genetics
Academic Journal
Title :
Elements at the 5' end of Xist harbor SPEN-independent transcriptional antiterminator activity.
Authors :
Trotman JB; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Lee DM; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, Chapel Hill, NC 27599, USA.
Cherney RE; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, Chapel Hill, NC 27599, USA.
Kim SO; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Inoue K; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Schertzer MD; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, Chapel Hill, NC 27599, USA.
Bischoff SR; Animal Models Core, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.
Cowley DO; Animal Models Core, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.
Calabrese JM; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10500-10517.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
DNA-Binding Proteins/*genetics
RNA, Long Noncoding/*genetics
RNA-Binding Proteins/*genetics
X Chromosome Inactivation/*genetics
Animals ; Chromatin/genetics ; Gene Expression Regulation, Developmental/genetics ; Gene Silencing ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Polyadenylation/genetics ; Repetitive Sequences, Nucleic Acid/genetics ; X Chromosome/genetics
Academic Journal
Title :
Epigenetic silencing of clustered tRNA genes in Arabidopsis.
Authors :
Hummel G; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Berr A; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Graindorge S; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Cognat V; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Ubrig E; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Pflieger D; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Molinier J; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Drouard L; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10297-10312.
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Epigenesis, Genetic/*genetics
RNA Polymerase III/*genetics
RNA, Transfer/*genetics
Arabidopsis/genetics ; Cell Nucleus/genetics ; Chromatin/genetics ; Gene Silencing ; Multigene Family/genetics
Academic Journal
Title :
Pressure regulated basis for gene transcription by delta-cell micro-compliance modeled in silico: Biphenyl, bisphenol and small molecule ligand models of cell contraction-expansion.
Authors :
Sarin H; Freelance Investigator in Translational Science and Medicine, Charleston, West Virginia, United States of America.
Show more
Source :
PloS one [PLoS One] 2020 Oct 06; Vol. 15 (10), pp. e0236446. Date of Electronic Publication: 2020 Oct 06 (Print Publication: 2020).
Publication Type :
Journal Article
MeSH Terms :
Cell Physiological Phenomena*
Computer Simulation*
Gene Expression Regulation*
Transcription, Genetic*
Benzhydryl Compounds/*metabolism
Biphenyl Compounds/*metabolism
Phenols/*metabolism
Small Molecule Libraries/*metabolism
Algorithms ; Cell Proliferation ; Humans ; Ligands ; Pressure
Academic Journal
Title :
Transcriptional regulation by methyltransferases and their role in the heart: highlighting novel emerging functionality.
Authors :
Szulik MW; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.
Davis K; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.
Bakhtina A; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.
Azarcon P; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.
Bia R; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.
Horiuchi E; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.
Franklin S; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah.; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Show more
Source :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2020 Oct 01; Vol. 319 (4), pp. H847-H865. Date of Electronic Publication: 2020 Aug 21.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Epigenesis, Genetic*
Protein Processing, Post-Translational*
Transcription, Genetic*
Myocardium/*enzymology
Protein Methyltransferases/*metabolism
Animals ; Chromatin Assembly and Disassembly ; DNA Methylation ; Heart Diseases/enzymology ; Heart Diseases/genetics ; Humans ; Methylation ; Mice ; Transcriptional Activation
Academic Journal
Title :
LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis.
Authors :
Chen K; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China. Electronic address: .
Fang H; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China.
Xu N; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China.
Show more
Source :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118095. Date of Electronic Publication: 2020 Jul 14.
Publication Type :
Journal Article
MeSH Terms :
Signal Transduction*
Transcription, Genetic*
Histone Demethylases/*metabolism
MicroRNAs/*metabolism
Osteoarthritis/*genetics
Proto-Oncogene Proteins c-jun/*metabolism
RNA, Long Noncoding/*metabolism
Apoptosis/genetics ; Base Sequence ; Cell Proliferation/genetics ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Disease Progression ; Gene Silencing ; Histone Demethylases/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; MicroRNAs/genetics ; Osteoarthritis/pathology ; RNA, Long Noncoding/genetics
Academic Journal
Title :
Transcription imparts architecture, function and logic to enhancer units.
Authors :
Tippens ND; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.; Department of Computational Biology, Cornell University, Ithaca, NY, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.; Tri-Institutional Training Program in Computational Biology and Medicine, Cornell University, Ithaca, NY, USA.
Liang J; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.
Leung AK; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.; Department of Computational Biology, Cornell University, Ithaca, NY, USA.
Wierbowski SD; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.; Department of Computational Biology, Cornell University, Ithaca, NY, USA.
Ozer A; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Booth JG; Department of Statistics and Data Science, Cornell University, Ithaca, NY, USA.
Lis JT; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. .; Tri-Institutional Training Program in Computational Biology and Medicine, Cornell University, Ithaca, NY, USA. .
Yu H; Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA. .; Department of Computational Biology, Cornell University, Ithaca, NY, USA. .; Tri-Institutional Training Program in Computational Biology and Medicine, Cornell University, Ithaca, NY, USA. .
Show more
Source :
Nature genetics [Nat Genet] 2020 Oct; Vol. 52 (10), pp. 1067-1075. Date of Electronic Publication: 2020 Sep 21.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Initiation Site*
Transcription, Genetic*
Enhancer Elements, Genetic/*genetics
Histone Code/*genetics
Cell Line ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Humans ; Promoter Regions, Genetic/genetics ; Protein Processing, Post-Translational/genetics ; Transcription Initiation, Genetic
Academic Journal
Title :
Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells.
Authors :
Wei F; Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. .
Xu X; Department of Applied Mechanics, Beijing Institute of Technology, 100081, Beijing, China.
Zhang C; Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Liao Y; Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Ji B; Biomechanics and Biomaterials Laboratory, Department of Engineering Mechanics, Zhejiang University, Hangzhou, 310027, Zhejiang, China. .
Wang N; Department of Mechanical Science and Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .
Show more
Source :
Nature communications [Nat Commun] 2020 Sep 29; Vol. 11 (1), pp. 4902. Date of Electronic Publication: 2020 Sep 29.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*chemistry
Stress Fibers/*chemistry
Tetrahydrofolate Dehydrogenase/*genetics
Transcription, Genetic/*physiology
Up-Regulation/*physiology
Animals ; Anisotropy ; Biomechanical Phenomena/genetics ; CHO Cells ; Chromatin/metabolism ; Cricetulus ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Intravital Microscopy ; Microscopy, Fluorescence ; Myosin Type II/antagonists & inhibitors ; Myosin Type II/metabolism ; Stress Fibers/drug effects ; Stress Fibers/metabolism ; Stress, Mechanical ; Transcription, Genetic/drug effects ; Up-Regulation/drug effects
Academic Journal
Title :
The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.
Authors :
Zárate-Potes A; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Yang W; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Pees B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Schalkowski R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Segler P; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Andresen B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Haase D; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Nakad R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Rosenstiel P; Institute for Clinical Molecular Biology (IKMB), Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Tetreau G; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Colletier JP; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Schulenburg H; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Ploen, Germany.
Dierking K; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Show more
Source :
PLoS pathogens [PLoS Pathog] 2020 Sep 24; Vol. 16 (9), pp. e1008826. Date of Electronic Publication: 2020 Sep 24 (Print Publication: 2020).
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Transcription, Genetic*
Bacillus thuringiensis/*metabolism
Bacterial Infections/*metabolism
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
GATA Transcription Factors/*metabolism
Animals ; Bacillus thuringiensis/pathogenicity ; Bacterial Infections/genetics ; Bacterial Infections/microbiology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/microbiology ; Caenorhabditis elegans Proteins/genetics ; GATA Transcription Factors/genetics
Academic Journal
Title :
Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency.
Authors :
Krasnopolsky S; The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Kuzmina A; The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Taube R; The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Show more
Source :
PLoS pathogens [PLoS Pathog] 2020 Sep 21; Vol. 16 (9), pp. e1008834. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Viral*
Gene Silencing*
Repressor Proteins*/genetics
Repressor Proteins*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Transcription, Genetic*
Virus Latency*
CD4-Positive T-Lymphocytes/*metabolism
HIV-1/*physiology
CD4-Positive T-Lymphocytes/virology ; CRISPR-Cas Systems ; Gene Knockout Techniques ; Genome-Wide Association Study ; Humans ; Jurkat Cells ; Promoter Regions, Genetic ; Tripartite Motif-Containing Protein 28/genetics ; Tripartite Motif-Containing Protein 28/metabolism
Academic Journal
Title :
Uncoupling gene expression noise along the central dogma using genome engineered human cell lines.
Authors :
Quarton T; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.
Kang T; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.
Papakis V; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
Nguyen K; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
Nowak C; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
Li Y; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.
Bleris L; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 18; Vol. 48 (16), pp. 9406-9413.
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Editing*
Transcription, Genetic*
CRISPR-Cas Systems/*genetics
Genome, Human/*genetics
Cell Line ; Gene Expression Regulation/genetics ; Humans ; Models, Genetic ; Protein Biosynthesis/genetics ; Stochastic Processes
Academic Journal
Title :
Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains.
Authors :
Smalakyte D; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Kazlauskiene M; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
F Havelund J; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark.
Rukšėnaitė A; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Rimaite A; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Tamulaitiene G; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Færgeman NJ; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark.
Tamulaitis G; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Siksnys V; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 18; Vol. 48 (16), pp. 9204-9217.
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems/*genetics
Immunity/*genetics
Streptococcus thermophilus/*genetics
Transcription, Genetic/*genetics
Chromatography, High Pressure Liquid ; Endonucleases/genetics ; Escherichia coli/genetics ; Escherichia coli/immunology ; Protein Domains/genetics ; RNA Stability/genetics ; RNA Stability/immunology ; Ribonucleases/genetics ; Signal Transduction/genetics ; Streptococcus thermophilus/immunology ; Transcription, Genetic/immunology
Academic Journal
Title :
Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis.
Authors :
Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8243-8254.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gene Expression Regulation, Fungal*
Transcription, Genetic*
RNA, Long Noncoding/*genetics
Saccharomycetales/*genetics
Schizosaccharomyces/*genetics
Homeostasis ; Nutrients/metabolism ; Phosphoglycerate Dehydrogenase/genetics ; Phosphoglycerate Dehydrogenase/metabolism ; RNA, Messenger ; Regulon ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomycetales/metabolism ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism
Academic Journal
Title :
NC2 complex is a key factor for the activation of catalase-3 transcription by regulating H2A.Z deposition.
Authors :
Cui G; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Dong Q; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Duan J; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Zhang C; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Liu X; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China.
He Q; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8332-8348.
Publication Type :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Catalase/*genetics
Phosphoproteins/*genetics
Transcription Factors/*genetics
Cell Nucleus/genetics ; Chromatin Assembly and Disassembly/genetics ; Gene Expression Regulation/genetics ; Genes, MHC Class II/genetics ; Histones/genetics ; Neurospora crassa/genetics ; Nucleosomes/genetics ; Nucleosomes/ultrastructure ; Phosphoproteins/ultrastructure ; Protein Binding/genetics ; Transcription Factors/ultrastructure ; Transcriptional Activation/genetics
Academic Journal
Title :
Chromatin remodeler Ino80C acts independently of H2A.Z to evict promoter nucleosomes and stimulate transcription of highly expressed genes in yeast.
Authors :
Qiu H; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Biernat E; Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA.
Govind CK; Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA.
Rawal Y; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Chereji RV; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Clark DJ; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Hinnebusch AG; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Show more
Source :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8408-8430.
Publication Type :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Histones/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Transcriptional Activation/*genetics
Adenosine Triphosphatases/genetics ; Chromatin/genetics ; Chromatin Assembly and Disassembly/genetics ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Fungal/genetics ; Nucleosomes/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/chemistry ; Transcription Factors/genetics
Academic Journal

We use cookies to help identify your computer so we can tailor your user experience, track shopping basket contents and remember where you are in the order process.