Temat: "Transcription, Genetic" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.
Autorzy:: Gu X; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Nardone C; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Kamitaki N; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Mao A; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Elledge SJ; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Greenberg ME; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Aug 25; Vol. 381 (6660), pp. eadh5021. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:: Journal Article
MeSH Terms:: Nuclear Proteins*/chemistry
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Proteasome Endopeptidase Complex*
Proteolysis*
Genes, Immediate-Early*
Transcription, Genetic*
Ubiquitin ; Ubiquitination ; HEK293 Cells ; NIH 3T3 Cells

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Skocz do pozycji: 2.

Tytuł:: Metabolic control of transcription.
Autorzy:: Taylor EB; Department of Molecular Physiology and Biophysics and Fraternal Orders of Eagle Diabetes Research Center, Holden Comprehensive Cancer Center, Abboud Cardiovascular Research Center, Pappajohn Biomedical Discovery Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Jul 14; Vol. 381 (6654), pp. 125-126. Date of Electronic Publication: 2023 Jul 13.
Typ publikacji:: Journal Article
MeSH Terms:: Ketoglutarate Dehydrogenase Complex*/genetics
Protein Processing, Post-Translational*
Transcription, Genetic*
Gene Expression Regulation, Plant*
Arabidopsis*/enzymology
Arabidopsis*/genetics
Methylation

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Skocz do pozycji: 3.

Tytuł:: Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin.
Autorzy:: Pownall ME; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Miao L; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Vejnar CE; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
M'Saad O; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.
Sherrard A; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Frederick MA; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Benitez MDJ; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Boswell CW; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Zaret KS; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bewersdorf J; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.; Department of Physics, Yale University, New Haven, CT 06510, USA.; Nanobiology Institute, Yale University, West Haven, CT 06477, USA.
Giraldez AJ; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA.; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Jul 07; Vol. 381 (6653), pp. 92-100. Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:: Journal Article
MeSH Terms:: Chromatin*/chemistry
Transcription, Genetic*
Microscopy, Fluorescence*/methods
Zygote*/metabolism
Nucleosomes/chemistry ; RNA Polymerase II/chemistry ; RNA Polymerase II/metabolism ; Animals ; Zebrafish ; Embryo, Nonmammalian ; Nanog Homeobox Protein/chemistry ; Nanog Homeobox Protein/metabolism

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Skocz do pozycji: 4.

Tytuł:: An expanded view of transcription.
Autorzy:: Stasevich TJ; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
Kimura H; Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Jul 07; Vol. 381 (6653), pp. 26-27. Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:: Journal Article
MeSH Terms:: Chromatin*
Transcription, Genetic*
Microscopy, Fluorescence*/methods
Animals ; Molecular Imaging/methods

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Skocz do pozycji: 5.

Tytuł:: Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome.
Autorzy:: Brückner DB; Institute of Science and Technology, Am Campus 1, Klosterneuburg, Austria.
Chen H; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Barinov L; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zoller B; Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ, USA.; Department of Developmental and Stem Cell Biology, CNRS UMR3738 Paris Cité, Institut Pasteur, Paris, France.
Gregor T; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ, USA.; Department of Developmental and Stem Cell Biology, CNRS UMR3738 Paris Cité, Institut Pasteur, Paris, France.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Jun 30; Vol. 380 (6652), pp. 1357-1362. Date of Electronic Publication: 2023 Jun 29.
Typ publikacji:: Journal Article
MeSH Terms:: Chromosomes*/chemistry
Chromosomes*/genetics
DNA*/chemistry
DNA*/genetics
Transcription, Genetic*
Molecular Imaging*/methods
Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Cell Nucleus/metabolism ; Eukaryota ; Polymers/chemistry ; Animals ; Drosophila

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Skocz do pozycji: 6.

Tytuł:: Deterministic reprogramming of neutrophils within tumors.
Autorzy:: Ng MSF; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Kwok I; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Tan L; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Shi C; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cerezo-Wallis D; Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Tan Y; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; National Skin Centre, National Healthcare Group, Singapore.
Leong K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Calvo GF; Department of Mathematics & MOLAB-Mathematical Oncology Laboratory, University of Castilla-La Mancha, Ciudad Real, Spain.
Yang K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Zhang Y; Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Immunology Program, Life Science Institute, National University of Singapore, Singapore.
Jin J; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liong KH; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Wu D; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
He R; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu D; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Teh YC; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Bleriot C; INSERM U1015, Institut Gustave Roussy, Villejuif, France.; CNRS UMR8253, Institut Necker des Enfants Malades, Paris, France.
Caronni N; Genomics of the Innate Immune System Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Liu Z; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Duan K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Narang V; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Ballesteros I; Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
Moalli F; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Li M; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Chen J; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Liu Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.
Liu L; Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.
Qi J; Department of Biliary and Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Cancer Biology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Y; Department of Biliary and Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Cancer Biology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiang L; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; State Key Laboratory of Oncogenes and Related Genes, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shen B; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; State Key Laboratory of Oncogenes and Related Genes, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Cheng H; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Cheng T; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Angeli V; Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Immunology Program, Life Science Institute, National University of Singapore, Singapore.
Sharma A; Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, Western Australia, Australia.; Curtin Medical School, Curtin University, Bentley, Western Australia, Australia.; Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.
Loh YH; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore.
Tey HL; National Skin Centre, National Healthcare Group, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Chong SZ; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Microbiology and Immunology, National University of Singapore, Singapore.
Iannacone M; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Ostuni R; Genomics of the Innate Immune System Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Hidalgo A; Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; INSERM U1015, Institut Gustave Roussy, Villejuif, France.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore.
Ng LG; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Microbiology and Immunology, National University of Singapore, Singapore.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2024 Jan 12; Vol. 383 (6679), pp. eadf6493. Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:: Journal Article
MeSH Terms:: Neoplasms*/blood supply
Neoplasms*/immunology
Neutrophils*/immunology
Cellular Reprogramming*/genetics
Cellular Reprogramming*/immunology
Neovascularization, Pathologic*/genetics
Neovascularization, Pathologic*/immunology
Humans ; Proteomics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/immunology ; Epigenesis, Genetic ; Hypoxia ; Transcription, Genetic

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Skocz do pozycji: 7.

Tytuł:: Hippo signaling instructs ectopic but not normal organ growth.
Autorzy:: Kowalczyk W; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
Romanelli L; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
Atkins M; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.; Department of Biological Sciences, Sam Houston State University, Huntsville, TX, USA.
Hillen H; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
Bravo González-Blas C; VIB Center for Brain and Disease Research and KU Leuven Department of Neurosciences, KU Leuven, Leuven, Belgium.
Jacobs J; VIB Center for Brain and Disease Research and KU Leuven Department of Neurosciences, KU Leuven, Leuven, Belgium.
Xie J; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
Soheily S; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
Verboven E; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
Moya IM; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.; Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Américas, Quito, Ecuador.
Verhulst S; Department for Cell Biology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussel-Jette, Belgium.
de Waegeneer M; VIB Center for Brain and Disease Research and KU Leuven Department of Neurosciences, KU Leuven, Leuven, Belgium.
Sansores-Garcia L; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
van Huffel L; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.
Johnson RL; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
van Grunsven LA; Department for Cell Biology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussel-Jette, Belgium.
Aerts S; VIB Center for Brain and Disease Research and KU Leuven Department of Neurosciences, KU Leuven, Leuven, Belgium.
Halder G; VIB Center for Cancer Biology and KU Leuven Department of Oncology, KU Leuven, Leuven, Belgium.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Nov 18; Vol. 378 (6621), pp. eabg3679. Date of Electronic Publication: 2022 Nov 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drosophila melanogaster*/embryology
Drosophila melanogaster*/genetics
Eye*/embryology
Gene Expression Regulation, Developmental*
Hippo Signaling Pathway*/genetics
Liver*/embryology
Transcription, Genetic*
Transcriptional Coactivator with PDZ-Binding Motif Proteins*/metabolism
YAP-Signaling Proteins*/metabolism
Animals ; Mice ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Organ Size ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Trans-Activators/genetics

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Skocz do pozycji: 8.

Tytuł:: Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs.
Autorzy:: Xu Y; School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.; School of Life Sciences, Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Zhu TF; School of Life Sciences, Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Oct 28; Vol. 378 (6618), pp. 405-412. Date of Electronic Publication: 2022 Oct 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Ribosomes*
RNA, Catalytic*/genetics
RNA, Ribosomal, 23S*/biosynthesis
RNA, Ribosomal, 23S*/chemistry
RNA, Ribosomal, 23S*/genetics
RNA, Ribosomal, 5S*/biosynthesis
RNA, Ribosomal, 5S*/genetics
Transcription, Genetic*
DNA-Directed DNA Polymerase*/chemical synthesis
DNA-Directed DNA Polymerase*/chemistry
Viral Proteins*/chemical synthesis
Viral Proteins*/chemistry
Nucleic Acid Conformation ; RNA, Ribosomal, 16S/biosynthesis ; RNA, Ribosomal, 16S/genetics

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Skocz do pozycji: 9.

Tytuł:: From telomere to telomere: The transcriptional and epigenetic state of human repeat elements.
Autorzy:: Hoyt SJ; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Storer JM; Institute for Systems Biology, Seattle, WA, USA.
Hartley GA; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Grady PGS; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Gershman A; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD, USA.
de Lima LG; Stowers Institute for Medical Research, Kansas City, MO, USA.
Limouse C; Department of Biochemistry, Stanford University, Stanford, CA, USA.
Halabian R; Institute of Bioinformatics, Faculty of Medicine, University of Münster, Münster, Germany.
Wojenski L; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
Rodriguez M; Institute of Bioinformatics, Faculty of Medicine, University of Münster, Münster, Germany.
Altemose N; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Rhie A; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Core LJ; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Gerton JL; Stowers Institute for Medical Research, Kansas City, MO, USA.
Makalowski W; Institute of Bioinformatics, Faculty of Medicine, University of Münster, Münster, Germany.
Olson D; Department of Computer Science, University of Montana, Missoula, MT, USA.
Rosen J; Institute for Systems Biology, Seattle, WA, USA.
Smit AFA; Institute for Systems Biology, Seattle, WA, USA.
Straight AF; Department of Biochemistry, Stanford University, Stanford, CA, USA.
Vollger MR; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Wheeler TJ; Department of Computer Science, University of Montana, Missoula, MT, USA.
Schatz MC; Department of Computer Science and Department of Biology, Johns Hopkins University, Baltimore, MD, USA.
Eichler EE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
Phillippy AM; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Timp W; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Miga KH; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
O'Neill RJ; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Apr; Vol. 376 (6588), pp. eabk3112. Date of Electronic Publication: 2022 Apr 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Epigenesis, Genetic*
Genome, Human*
Repetitive Sequences, Nucleic Acid*
Transcription, Genetic*
Telomere/*genetics
Humans

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Skocz do pozycji: 10.

Tytuł:: Transcriptional neighborhoods regulate transcript isoform lengths and expression levels.
Autorzy:: Brooks AN; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Hughes AL; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Clauder-Münster S; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Mitchell LA; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.
Boeke JD; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY 11201, USA.
Steinmetz LM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.; Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.; Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Mar 04; Vol. 375 (6584), pp. 1000-1005. Date of Electronic Publication: 2022 Mar 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genome, Fungal*
Transcription, Genetic*
Transcriptome*
RNA, Fungal/*genetics
RNA, Messenger/*genetics
Saccharomyces cerevisiae/*genetics
3' Untranslated Regions ; Base Sequence ; Gene Rearrangement ; Genetic Variation ; RNA, Fungal/chemistry ; RNA, Fungal/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; RNA-Seq ; Sequence Analysis, RNA

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Skocz do pozycji: 11.

Tytuł:: Genome organization controls transcriptional dynamics during development.
Autorzy:: Batut PJ; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Bing XY; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Sisco Z; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Raimundo J; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Levo M; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Levine MS; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Feb 04; Vol. 375 (6580), pp. 566-570. Date of Electronic Publication: 2022 Feb 03.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Gene Expression Regulation, Developmental*
Genes, Homeobox*
Genome, Insect*
Transcription, Genetic*
Drosophila/*genetics
Animals ; Chromatin/chemistry ; Chromatin/genetics ; Chromosomes, Insect/chemistry ; Chromosomes, Insect/genetics ; Drosophila/embryology ; Enhancer Elements, Genetic ; Genes, Insect ; Promoter Regions, Genetic ; Regulatory Sequences, Nucleic Acid ; Single-Cell Analysis

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Skocz do pozycji: 12.

Tytuł:: Structural basis of Integrator-mediated transcription regulation.
Autorzy:: Fianu I; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Chen Y; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Dienemann C; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Dybkov O; Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
Linden A; Bioanalytical Mass Spectrometry, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.; Institute of Clinical Chemistry, Bioanalytics Group, University Medical Center Göttingen, 37075 Göttingen, Germany.
Urlaub H; Bioanalytical Mass Spectrometry, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.; Institute of Clinical Chemistry, Bioanalytics Group, University Medical Center Göttingen, 37075 Göttingen, Germany.
Cramer P; Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 Nov 12; Vol. 374 (6569), pp. 883-887. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation*
Transcription, Genetic*
Multiprotein Complexes/*chemistry
Protein Phosphatase 2/*chemistry
RNA Polymerase II/*chemistry
Cryoelectron Microscopy ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Endoribonucleases/chemistry ; Endoribonucleases/metabolism ; Humans ; Models, Molecular ; Multiprotein Complexes/metabolism ; Protein Binding ; Protein Conformation ; Protein Domains ; Protein Phosphatase 2/metabolism ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; RNA/metabolism ; RNA Polymerase II/metabolism

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Skocz do pozycji: 13.

Tytuł:: A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions.
Autorzy:: Desai RV; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program and Tetrad Graduate Program, University of California, San Francisco, CA 94158, USA.
Chen X; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.
Martin B; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.; Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, the Netherlands.
Chaturvedi S; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA.
Hwang DW; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Li W; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Yu C; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.
Ding S; Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA.; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Thomson M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Singer RH; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Coleman RA; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hansen MMK; Institute for Molecules and Materials, Radboud University, 6525 AJ Nijmegen, the Netherlands.
Weinberger LS; Gladstone/UCSF Center for Cell Circuitry, Gladstone Institutes, San Francisco, CA 94158, USA. .; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 Aug 20; Vol. 373 (6557). Date of Electronic Publication: 2021 Jul 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Differentiation*
Cellular Reprogramming*
DNA Repair*
Gene Expression*/drug effects
Transcription, Genetic*/drug effects
DNA/*chemistry
DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism
Animals ; Cells, Cultured ; Computer Simulation ; DNA/genetics ; DNA/metabolism ; Embryonic Stem Cells ; Idoxuridine/metabolism ; Idoxuridine/pharmacology ; Mice ; Models, Genetic ; Nanog Homeobox Protein/genetics ; Nucleic Acid Conformation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Single-Cell Analysis ; Stochastic Processes ; Thymidine Kinase/genetics ; Thymidine Kinase/metabolism

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Skocz do pozycji: 14.

Tytuł:: Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis.
Autorzy:: Rossmann MP; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Hoi K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Chan V; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Abraham BJ; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Yang S; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Mullahoo J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Papanastasiou M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Wang Y; Department of Biology, McGill University, Montréal, Québec H3A 1B1, Canada.
Elia I; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Perlin JR; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Hagedorn EJ; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Hetzel S; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Weigert R; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Vyas S; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Nag PP; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Sullivan LB; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Warren CR; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Dorjsuren B; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Greig EC; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Adatto I; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Cowan CA; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Schreiber SL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Meissner A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Hekimi S; Department of Biology, McGill University, Montréal, Québec H3A 1B1, Canada.
Carr SA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Zon LI; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA. .; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 May 14; Vol. 372 (6543), pp. 716-721.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Erythropoiesis*
Transcription, Genetic*
Mitochondria/*metabolism
Transcription Factors/*metabolism
Zebrafish Proteins/*metabolism
Animals ; Citric Acid Cycle ; DNA Methylation ; Dihydroorotate Dehydrogenase ; Electron Transport ; Embryo, Nonmammalian/metabolism ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation ; Histones/metabolism ; Leflunomide/pharmacology ; Metabolic Networks and Pathways ; Methylation ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors ; Oxygen Consumption ; Transcription Factors/genetics ; Ubiquinone/metabolism ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics

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Skocz do pozycji: 15.

Tytuł:: Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.
Autorzy:: Hata M; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.; Department of Biochemistry and Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Andriessen EMMA; Department of Biomedical Sciences, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Hata M; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Diaz-Marin R; Department of Biochemistry and Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Fournier F; Department of Biochemistry and Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Crespo-Garcia S; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.; Department of Biochemistry and Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Blot G; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.; Department of Biochemistry and Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Juneau R; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Pilon F; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Dejda A; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Guber V; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Heckel E; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal, Quebec H3T 1C5, Canada.
Daneault C; Department of Nutrition, University of Montreal, Montreal, Quebec, Plateforme métabolomique de l'Institut de Cardiologie de Montréal, Montreal, Quebec H3C 3J7, Canada.
Calderon V; Bioinformatics & Molecular Biology Core Facility, Institut de Recherches Cliniques de Montréal, Montreal, Quebec H2W 1R7, Canada.
Des Rosiers C; Department of Nutrition, University of Montreal, Montreal, Quebec, Plateforme métabolomique de l'Institut de Cardiologie de Montréal, Montreal, Quebec H3C 3J7, Canada.
Melichar HJ; Department of Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Langmann T; Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Joyal JS; Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montreal, Quebec H3T 1C5, Canada.
Wilson AM; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.
Sapieha P; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.; Department of Biochemistry and Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec H1T 2M4, Canada.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2023 Jan 06; Vol. 379 (6627), pp. 45-62. Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:: Journal Article
MeSH Terms:: Immunity, Innate*/genetics
Neuroinflammatory Diseases*/genetics
Neuroinflammatory Diseases*/immunology
Obesity*/genetics
Macular Degeneration*/genetics
Macular Degeneration*/immunology
Epigenetic Memory*
Animals ; Mice ; Cytokines/genetics ; Phagocytes/immunology ; Transcription, Genetic ; Cellular Reprogramming/genetics ; Toll-Like Receptor 4/genetics

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Skocz do pozycji: 16.

Tytuł:: Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria.
Autorzy:: Balakrishnan R; Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA.
Mori M; Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA.
Segota I; Departments of Medicine and Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.
Zhang Z; Section of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
Aebersold R; Faculty of Science, University of Zurich, Zürich, Switzerland.; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zürich, Switzerland.
Ludwig C; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University of Munich (TUM), Freising, Germany.
Hwa T; Department of Physics, University of California at San Diego, La Jolla, CA 92093, USA.; Section of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Dec 09; Vol. 378 (6624), pp. eabk2066. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Bacterial*
Protein Biosynthesis*/genetics
Escherichia coli*/genetics
RNA, Messenger*/genetics
RNA, Messenger*/metabolism
RNA, Bacterial/genetics ; DNA, Bacterial/genetics ; Promoter Regions, Genetic ; Transcription, Genetic

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Skocz do pozycji: 17.

Tytuł:: Autobiography of a gut bacterium.
Autorzy:: Schmidt F; Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Nov 25; Vol. 378 (6622), pp. 844-845. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:: Journal Article
MeSH Terms:: Bacteria*/genetics
Gastrointestinal Microbiome*/genetics
Intestines*/microbiology
Humans ; Transcription, Genetic

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Skocz do pozycji: 18.

Tytuł:: RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
Autorzy:: Strecker J; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Demircioglu FE; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Li D; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Faure G; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Wilkinson ME; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gootenberg JS; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Abudayyeh OO; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Nishimasu H; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.; Inamori Research Institute for Science, Kyoto 600-8411, Japan.
Macrae RK; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Zhang F; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Nov 25; Vol. 378 (6622), pp. 874-881. Date of Electronic Publication: 2022 Nov 03.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: CRISPR-Cas Systems*
Endopeptidases*/chemistry
Endopeptidases*/metabolism
CRISPR-Associated Proteins*/chemistry
CRISPR-Associated Proteins*/metabolism
Proteolysis*
Deltaproteobacteria*/enzymology
Deltaproteobacteria*/genetics
RNA, Guide, CRISPR-Cas Systems*/chemistry
RNA, Guide, CRISPR-Cas Systems*/metabolism
Bacterial Proteins*/chemistry
Bacterial Proteins*/metabolism
Humans ; Cryoelectron Microscopy ; RNA, Bacterial/chemistry ; RNA, Bacterial/metabolism ; Sigma Factor/metabolism ; Transcription, Genetic ; Substrate Specificity ; Allosteric Regulation ; Enzyme Activation

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Skocz do pozycji: 19.

Tytuł:: Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Autorzy:: Ehara H; RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan.
Kujirai T; RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan.; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
Shirouzu M; RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan.
Kurumizaka H; RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan.; Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
Sekine SI; RIKEN Center for Biosystems Dynamics Research, Tsurumi-ku, Yokohama 230-0045, Japan.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Sep 09; Vol. 377 (6611), pp. eabp9466. Date of Electronic Publication: 2022 Aug 18.
Typ publikacji:: Journal Article
MeSH Terms:: Chromatin*/chemistry
Histone Chaperones*/chemistry
Nucleosomes*/chemistry
RNA Polymerase II*/chemistry
Transcriptional Elongation Factors*/chemistry
Cryoelectron Microscopy ; DNA ; Humans ; Saccharomycetales ; Transcription, Genetic
SCR Organism:: Komagataella pastoris

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Skocz do pozycji: 20.

Tytuł:: Structural basis of transcription-translation coupling.
Autorzy:: Wang C; Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Molodtsov V; Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
Firlar E; Rutgers New Jersey CryoEM/CryoET Core Facility and Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA.
Kaelber JT; Rutgers New Jersey CryoEM/CryoET Core Facility and Institute for Quantitative Biomedicine, Rutgers University, Piscataway, NJ 08854, USA.
Blaha G; Department of Biochemistry, University of California, Riverside, CA 92521, USA.
Su M; Life Sciences Institute, University of Michigan, Ann Arbor, MI,48109, USA. .
Ebright RH; Waksman Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2020 Sep 11; Vol. 369 (6509), pp. 1359-1365. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Protein Biosynthesis*
Transcription, Genetic*
DNA-Directed RNA Polymerases/*chemistry
Escherichia coli/*genetics
Escherichia coli Proteins/*chemistry
Peptide Elongation Factors/*chemistry
Transcription Factors/*chemistry
Transcriptional Elongation Factors/*chemistry
Cryoelectron Microscopy ; Gene Expression Regulation, Bacterial ; Protein Binding ; Protein Conformation ; RNA, Messenger/chemistry

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