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Wyszukujesz frazę ""Transcription, Genetic"" wg kryterium: Temat


Tytuł :
Primary Role of the Nucleosome.
Autorzy :
Kornberg RD; Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA.
Lorch Y; Department of Structural Biology, Stanford School of Medicine, Stanford, CA 94305, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 06; Vol. 79 (3), pp. 371-375.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Transcription, Genetic*
Chromosomal Proteins, Non-Histone/*genetics
Nucleosomes/*metabolism
RNA Polymerase II/*genetics
Saccharomyces cerevisiae/*genetics
Transcription Factors/*genetics
Animals ; Binding Sites ; Chromatin Assembly and Disassembly ; Chromosomal Proteins, Non-Histone/metabolism ; Evolution, Molecular ; Gene Expression Regulation ; Histones/genetics ; Histones/metabolism ; Humans ; Nucleosomes/ultrastructure ; Promoter Regions, Genetic ; RNA Polymerase II/metabolism ; Saccharomyces cerevisiae/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
RNA Pol II Length and Disorder Enable Cooperative Scaling of Transcriptional Bursting.
Autorzy :
Quintero-Cadena P; California Institute of Technology, Division of Biology and Biological Engineering, Pasadena, CA, USA.
Lenstra TL; The Netherlands Cancer Institute, Oncode Institute, Division of Gene Regulation, Amsterdam, the Netherlands.
Sternberg PW; California Institute of Technology, Division of Biology and Biological Engineering, Pasadena, CA, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jul 16; Vol. 79 (2), pp. 207-220.e8. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
Transcription, Genetic*
RNA Polymerase II/*metabolism
Saccharomycetales/*enzymology
Saccharomycetales/*genetics
Amino Acid Sequence ; Models, Genetic ; RNA Polymerase II/chemistry ; RNA-Seq ; Structure-Activity Relationship ; Transcriptome
Czasopismo naukowe
Tytuł :
Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin.
Autorzy :
LeRoux M; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Culviner PH; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Liu YJ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Littlehale ML; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Laub MT; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jul 16; Vol. 79 (2), pp. 280-292.e8. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Bacterial*
Stress, Physiological*
Toxin-Antitoxin Systems*/genetics
Transcription, Genetic*
Bacterial Toxins/*metabolism
Escherichia coli/*genetics
Escherichia coli Proteins/*metabolism
DNA-Binding Proteins/metabolism ; Escherichia coli/growth & development ; Plasmids/genetics ; Proteolysis ; RNA, Bacterial/metabolism ; RNA-Seq
Czasopismo naukowe
Tytuł :
TFIID Enables RNA Polymerase II Promoter-Proximal Pausing.
Autorzy :
Fant CB; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Levandowski CB; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Gupta K; School of Biochemistry, Bristol Research Centre for Synthetic Biology, University of Bristol, Bristol, UK.
Maas ZL; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Moir J; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Rubin JD; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Sawyer A; Department of Biology, Brandeis University, Waltham, MA, USA.
Esbin MN; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Rimel JK; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Luyties O; Department of Biochemistry, University of Colorado, Boulder, CO, USA.
Marr MT; Department of Biology, Brandeis University, Waltham, MA, USA.
Berger I; School of Biochemistry, Bristol Research Centre for Synthetic Biology, University of Bristol, Bristol, UK.
Dowell RD; Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA; BioFrontiers Institute, University of Colorado, Boulder, CO, USA.
Taatjes DJ; Department of Biochemistry, University of Colorado, Boulder, CO, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 May 21; Vol. 78 (4), pp. 785-793.e8. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Promoter Regions, Genetic*
Transcription, Genetic*
Drosophila/*metabolism
Drosophila Proteins/*metabolism
RNA Polymerase II/*genetics
Transcription Factor TFIID/*metabolism
Animals ; Drosophila/genetics ; Drosophila Proteins/genetics ; HCT116 Cells ; Humans ; Protein Binding ; RNA Polymerase II/metabolism ; Transcription Factor TFIID/genetics
Czasopismo naukowe
Tytuł :
Gene-Specific Control of tRNA Expression by RNA Polymerase II.
Autorzy :
Gerber A; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA; Department of Chemistry and Pharmaceutical Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HZ Amsterdam, Netherlands. Electronic address: .
Ito K; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Chu CS; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA.
Roeder RG; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 May 21; Vol. 78 (4), pp. 765-778.e7. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Transcription, Genetic*
RNA Polymerase II/*metabolism
RNA Polymerase III/*metabolism
RNA, Transfer/*metabolism
Repressor Proteins/*metabolism
Retinol-Binding Proteins, Cellular/*metabolism
HeLa Cells ; Humans ; Protein Processing, Post-Translational ; RNA Polymerase II/genetics ; RNA Polymerase III/genetics ; RNA, Transfer/genetics ; Repressor Proteins/genetics ; Retinol-Binding Proteins, Cellular/genetics
Czasopismo naukowe
Tytuł :
Developmental Relationships of Four Exhausted CD8 T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
Autorzy :
Beltra JC; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA.
Manne S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Abdel-Hakeem MS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo, Egypt.
Kurachi M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Giles JR; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA.
Chen Z; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Casella V; Infection Biology Laboratory, Department of Experimental and Health Sciences (DCEXS), Universitat Pompeu Fabra, Barcelona, Spain.
Ngiow SF; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA.
Khan O; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Arsenal Biosciences, South San Francisco, CA, USA.
Huang YJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yan P; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Arsenal Biosciences, South San Francisco, CA, USA.
Nzingha K; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Xu W; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Amaravadi RK; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Xu X; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Karakousis GC; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mitchell TC; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Schuchter LM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Huang AC; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2020 May 19; Vol. 52 (5), pp. 825-841.e8. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Epigenesis, Genetic/*immunology
Neoplasms/*immunology
T-Lymphocyte Subsets/*immunology
Transcription, Genetic/*immunology
Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/immunology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; Epigenesis, Genetic/genetics ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Hepatocyte Nuclear Factor 1-alpha/immunology ; Homeodomain Proteins/genetics ; Homeodomain Proteins/immunology ; Humans ; Immunotherapy/methods ; Mice, Inbred C57BL ; Neoplasms/genetics ; Neoplasms/therapy ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/immunology ; T-Lymphocyte Subsets/metabolism ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding.
Autorzy :
Hsieh TS; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Cattoglio C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Slobodyanyuk E; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Hansen AS; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Rando OJ; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Tjian R; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: .
Darzacq X; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 May 07; Vol. 78 (3), pp. 539-553.e8. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcription, Genetic*
Chromatin/*chemistry
Chromatin/*metabolism
Chromatin Assembly and Disassembly/*genetics
Animals ; CCCTC-Binding Factor/genetics ; Chromatin/genetics ; DNA Polymerase II/genetics ; DNA Polymerase II/metabolism ; Embryonic Stem Cells/physiology ; Enhancer Elements, Genetic ; Gene Expression Regulation ; Genome Components ; Mice ; Promoter Regions, Genetic ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels.
Autorzy :
Slobodin B; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
Bahat A; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Sehrawat U; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Becker-Herman S; Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Zuckerman B; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Weiss AN; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Han R; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Elkon R; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Agami R; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Ulitsky I; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Shachar I; Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Dikstein R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 May 07; Vol. 78 (3), pp. 434-444.e5. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Poly A/*genetics
RNA, Messenger/*metabolism
Adenosine/analogs & derivatives ; Animals ; B-Lymphocytes/physiology ; Cells, Cultured ; Female ; Gene Expression Regulation ; Humans ; Internal Ribosome Entry Sites ; MCF-7 Cells ; Mice, Inbred C57BL ; Nuclear Receptor Subfamily 4, Group A, Member 2/genetics ; Nuclear Receptor Subfamily 4, Group A, Member 2/metabolism ; Poly A/metabolism ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA Stability ; RNA, Messenger/genetics ; Receptors, CCR4/genetics ; Receptors, CCR4/metabolism
Czasopismo naukowe
Tytuł :
Visualizing the Role of Boundary Elements in Enhancer-Promoter Communication.
Autorzy :
Yokoshi M; Laboratory of Transcription Dynamics, Research Center for Biological Visualization, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
Segawa K; Department of Bioinformatics and Systems Biology, Faculty of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan.
Fukaya T; Laboratory of Transcription Dynamics, Research Center for Biological Visualization, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Apr 16; Vol. 78 (2), pp. 224-235.e5. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
Promoter Regions, Genetic*
Transcription, Genetic*
Embryonic Development/*genetics
Animals ; Chromosomes/genetics ; Drosophila/genetics ; Drosophila/growth & development ; Embryo, Nonmammalian
Czasopismo naukowe
Tytuł :
NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release.
Autorzy :
Aoi Y; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Smith ER; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Shah AP; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Rendleman EJ; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Marshall SA; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Woodfin AR; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Chen FX; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Shiekhattar R; Department of Human Genetics, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Shilatifard A; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Apr 16; Vol. 78 (2), pp. 261-274.e5. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Positive Transcriptional Elongation Factor B/*genetics
RNA Polymerase II/*genetics
Transcription Factors/*genetics
Animals ; Heat-Shock Response/genetics ; Humans ; Mice ; Nucleosomes/genetics ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Cohesin Removal Reprograms Gene Expression upon Mitotic Entry.
Autorzy :
Perea-Resa C; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Bury L; Whitehead Institute for Biomedical Research, 455 Main St., Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Cheeseman IM; Whitehead Institute for Biomedical Research, 455 Main St., Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Blower MD; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Apr 02; Vol. 78 (1), pp. 127-140.e7. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Transcription, Genetic*
Cell Cycle Proteins/*physiology
Chromosomal Proteins, Non-Histone/*physiology
Mitosis/*genetics
Anaphase/genetics ; Animals ; Aurora Kinase B/analysis ; Cell Cycle ; Cell Cycle Proteins/analysis ; Cell Line ; Centromere/enzymology ; Chromosome Segregation ; G1 Phase/genetics ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Metaphase/genetics ; Prophase ; RNA Polymerase II/metabolism ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation.
Autorzy :
Son K; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Schärer OD; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. Electronic address: .
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Źródło :
Cell [Cell] 2020 Mar 19; Vol. 180 (6), pp. 1039-1041.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
RNA Polymerase II*
Transcription, Genetic*
DNA Damage ; DNA Repair ; Ubiquitination
Czasopismo naukowe
Tytuł :
Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.
Autorzy :
Cossa G; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Roeschert I; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Prinz F; Lab GBM Research 5, Research & Development, Pharmaceuticals, Bayer AG, Building S155, 13342 Berlin, Germany.
Baluapuri A; Cancer Systems Biology Group, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Silveira Vidal R; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Schülein-Völk C; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Chang YC; Technical University of Munich, Emil-Erlenmeyer Forum 5, 85354 Freising, Germany.
Ade CP; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Mastrobuoni G; Berlin Institute for Medical Systems Biology at The Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Girard C; Department of Cellular Biochemistry, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Wortmann L; Lab GBM Research 5, Research & Development, Pharmaceuticals, Bayer AG, Building S155, 13342 Berlin, Germany.
Walz S; Comprehensive Cancer Center Mainfranken, Core Unit Bioinformatics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Lührmann R; Department of Cellular Biochemistry, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Kempa S; Berlin Institute for Medical Systems Biology at The Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Kuster B; Technical University of Munich, Emil-Erlenmeyer Forum 5, 85354 Freising, Germany.
Wolf E; Cancer Systems Biology Group, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Mumberg D; Lab GBM Research 5, Research & Development, Pharmaceuticals, Bayer AG, Building S155, 13342 Berlin, Germany.
Eilers M; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Mar 19; Vol. 77 (6), pp. 1322-1339.e11. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Cell Nucleus/*metabolism
Chromatin/*metabolism
Protein Kinases/*metabolism
Protein Phosphatase 1/*antagonists & inhibitors
Proto-Oncogene Proteins c-myc/*metabolism
Repressor Proteins/*metabolism
Spliceosomes/*metabolism
Animals ; Cell Nucleus/genetics ; Chromatin/genetics ; Gene Expression Regulation ; HeLa Cells ; Humans ; Mice ; NIH 3T3 Cells ; Phosphorylation ; Protein Kinases/genetics ; Protein Phosphatase 1/genetics ; Protein Phosphatase 1/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA Splicing ; Repressor Proteins/genetics ; Spliceosomes/genetics
Czasopismo naukowe
Tytuł :
Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression.
Autorzy :
Tamburri S; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.
Lavarone E; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.
Fernández-Pérez D; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy; Department of Health Sciences, University of Milan, Via A. di Rudinì 8, 20142 Milan, Italy.
Conway E; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.
Zanotti M; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.
Manganaro D; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.
Pasini D; Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy; Department of Health Sciences, University of Milan, Via A. di Rudinì 8, 20142 Milan, Italy. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Feb 20; Vol. 77 (4), pp. 840-856.e5. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Transcription, Genetic*
Ubiquitination*
Histones/*metabolism
Polycomb Repressive Complex 1/*metabolism
Polycomb Repressive Complex 2/*metabolism
Cell Line ; Chromatin/metabolism ; Embryonic Stem Cells/metabolism ; Mutation, Missense ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 2/physiology ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.
Autorzy :
LaBella ML; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, USA.
Hujber EJ; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, USA.
Moore KA; Department of Biology, University of Utah, Salt Lake City, UT, USA.
Rawson RL; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, USA.
Merrill SA; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, USA.
Allaire PD; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, USA.
Ailion M; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Hollien J; Department of Biology, University of Utah, Salt Lake City, UT, USA.
Bastiani MJ; Department of Biology, University of Utah, Salt Lake City, UT, USA.
Jorgensen EM; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2020 Jan 06; Vol. 52 (1), pp. 88-103.e18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transcription, Genetic*
Ankyrins/*metabolism
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
Casein Kinase Idelta/*metabolism
Cell Nucleus/*metabolism
Phosphoprotein Phosphatases/*metabolism
Animals ; Ankyrins/genetics ; Axons/physiology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans Proteins/genetics ; Casein Kinase Idelta/genetics ; Cell Nucleus/genetics ; Phosphoprotein Phosphatases/genetics ; Synapses/physiology
Czasopismo naukowe
Tytuł :
N-Glycanase 1 Transcriptionally Regulates Aquaporins Independent of Its Enzymatic Activity.
Autorzy :
Tambe MA; Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: .
Ng BG; Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Freeze HH; Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
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Źródło :
Cell reports [Cell Rep] 2019 Dec 24; Vol. 29 (13), pp. 4620-4631.e4.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Aquaporin 1/*genetics
Aquaporins/*genetics
Congenital Disorders of Glycosylation/*genetics
Eye Diseases, Hereditary/*genetics
Lacrimal Apparatus Diseases/*genetics
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/*deficiency
Activating Transcription Factor 1/genetics ; Activating Transcription Factor 1/metabolism ; Animals ; Aquaporin 1/metabolism ; Aquaporins/metabolism ; Cell Line ; Congenital Disorders of Glycosylation/metabolism ; Congenital Disorders of Glycosylation/pathology ; Eye Diseases, Hereditary/metabolism ; Eye Diseases, Hereditary/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Gene Expression Regulation ; Genetic Complementation Test ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Lacrimal Apparatus Diseases/metabolism ; Lacrimal Apparatus Diseases/pathology ; Mice ; Mice, Knockout ; Osmosis ; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/antagonists & inhibitors ; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/genetics ; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/metabolism ; Polysaccharides/metabolism ; Primary Cell Culture ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction
SCR Disease Name :
Alacrima; NGLY1 deficiency
Czasopismo naukowe
Tytuł :
Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme.
Autorzy :
Carpenedo RL; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada. Electronic address: .
Kwon SY; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Tanner RM; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Yockell-Lelièvre J; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Choey C; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Doré C; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ho M; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Stewart DJ; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Perkins TJ; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
Stanford WL; The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada. Electronic address: .
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Źródło :
Stem cell reports [Stem Cell Reports] 2019 Dec 10; Vol. 13 (6), pp. 1111-1125.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Cell Differentiation/*genetics
Mesoderm/*cytology
Mesoderm/*metabolism
Pluripotent Stem Cells/*cytology
Pluripotent Stem Cells/*metabolism
Activins/pharmacology ; Bone Morphogenetic Protein 4/pharmacology ; Cell Culture Techniques ; Cell Differentiation/drug effects ; Cells, Cultured ; Endoderm/cytology ; Endoderm/metabolism ; Gene Expression Profiling ; Humans ; Pluripotent Stem Cells/drug effects ; Single-Cell Analysis ; Teratoma/etiology ; Time Factors ; Transcriptome
Czasopismo naukowe
Tytuł :
Watch Out for Those Terrible Twos! Dinucleotide Accumulation Dysregulates Mitochondrial Transcription.
Autorzy :
Noe Gonzalez M; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Svejstrup JQ; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Dec 05; Vol. 76 (5), pp. 696-698.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Mitochondria*
Transcription, Genetic*
Animals ; Mitophagy ; Promoter Regions, Genetic ; RNA
Czasopismo naukowe
Tytuł :
The Ongoing Quest to Crack the Genetic Code for Protein Production.
Autorzy :
Nieuwkoop T; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands.
Finger-Bou M; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands.
van der Oost J; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands.
Claassens NJ; Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708 WE Wageningen, the Netherlands. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Oct 15; Vol. 80 (2), pp. 193-209. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Code*
Protein Biosynthesis/*genetics
Algorithms ; Animals ; Biotechnology ; Humans ; RNA Stability ; Transcription, Genetic
Czasopismo naukowe

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