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Wyszukujesz frazę ""Transcription, Genetic"" wg kryterium: Temat


Tytuł :
NCBP3 positively impacts mRNA biogenesis.
Autorzy :
Dou Y; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Barbosa I; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
Jiang H; Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Iasillo C; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Molloy KR; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Schulze WM; European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9 38042, France.
Cusack S; European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9 38042, France.
Schmid M; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Le Hir H; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
LaCava J; Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.; European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen 9713 AV, Netherlands.
Jensen TH; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10413-10427.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
RNA/*genetics
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Active Transport, Cell Nucleus/genetics ; Cell Nucleus/genetics ; Exons ; Gene Expression Regulation/genetics ; Humans ; Nuclear Cap-Binding Protein Complex/genetics ; RNA Cap-Binding Proteins/genetics ; RNA Polymerase II/genetics ; RNA Stability/genetics ; RNA Transport/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast.
Autorzy :
Zhang Y; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, 69120, Heidelberg, Germany.
Kuster D; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, 69120, Heidelberg, Germany.
Schmidt T; DNA Repair Mechanisms and Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Kirrmaier D; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, 69120, Heidelberg, Germany.; Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.
Nübel G; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, 69120, Heidelberg, Germany.
Ibberson D; Deep Sequencing Core Facility, CellNetworks, Heidelberg University, 69120, Heidelberg, Germany.
Benes V; Genomics Core Facility, European Molecular Biology Laboratory (EMBL), 69117, Heidelberg, Germany.
Hombauer H; DNA Repair Mechanisms and Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, 69120, Heidelberg, Germany.
Knop M; Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, 69120, Heidelberg, Germany.; Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120, Heidelberg, Germany.
Jäschke A; Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, 69120, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 02; Vol. 11 (1), pp. 5508. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endoribonucleases/*metabolism
NAD/*metabolism
RNA Caps/*metabolism
RNA, Messenger/*metabolism
Saccharomyces cerevisiae/*genetics
5' Untranslated Regions ; Cell Nucleus/genetics ; Pyrophosphatases/metabolism ; RNA Stability ; RNA-Binding Proteins/metabolism ; Ribosomes/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus.
Autorzy :
Keep S; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Oade MS; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Lidzbarski-Silvestre F; School of Biosciences, Cardiff University, Cardiff, UK.; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Bentley K; School of Biology, University of St Andrews, St Andrews, UK.; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Stevenson-Leggett P; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Freimanis GL; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Tennakoon C; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Sanderson N; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Hammond JA; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Jones RC; School of Veterinary Science, University of Liverpool, Neston, UK.
Britton P; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
Bickerton E; The Pirbright Institute, Ash Road, Woking, GU24 0NF, UK.
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Źródło :
The Journal of general virology [J Gen Virol] 2020 Oct; Vol. 101 (10), pp. 1103-1118.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Infectious bronchitis virus/*genetics
RNA, Messenger/*genetics
RNA, Viral/*genetics
Regulatory Sequences, Nucleic Acid/*genetics
Transcription, Genetic/*genetics
5' Untranslated Regions/genetics ; Animals ; Base Sequence ; Cell Line ; Chickens ; Chlorocebus aethiops ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Open Reading Frames/genetics ; Poultry Diseases/virology ; Vero Cells ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
Dual-level autoregulation of the E. coli DeaD RNA helicase via mRNA stability and Rho-dependent transcription termination.
Autorzy :
Ojha S; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Jain C; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Sep; Vol. 26 (9), pp. 1160-1169. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD-box RNA Helicases/*genetics
Escherichia coli/*genetics
Homeostasis/*genetics
RNA Stability/*genetics
RNA, Messenger/*genetics
Transcription, Genetic/*genetics
5' Untranslated Regions/genetics ; Escherichia coli Proteins/genetics ; Gene Expression Regulation, Bacterial/genetics ; RNA, Bacterial/genetics
Czasopismo naukowe
Tytuł :
Influenza A virus utilizes noncanonical cap-snatching to diversify its mRNA/ncRNA.
Autorzy :
Li L; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, California 92521, USA.
Dai H; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, California 92521, USA.
Nguyen AP; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, California 92521, USA.
Hai R; Department of Microbiology and Plant Pathology, University of California, Riverside, California 92521, USA.
Gu W; Department of Molecular, Cell, and Systems Biology, University of California, Riverside, California 92521, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Sep; Vol. 26 (9), pp. 1170-1183. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Influenza A virus/*genetics
RNA Caps/*genetics
RNA, Messenger/*genetics
RNA, Untranslated/*genetics
A549 Cells ; Base Pairing/genetics ; Cell Line, Tumor ; Humans ; RNA Replicase/genetics ; RNA, Viral/genetics ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels.
Autorzy :
Slobodin B; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
Bahat A; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Sehrawat U; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Becker-Herman S; Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Zuckerman B; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Weiss AN; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Han R; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Elkon R; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Agami R; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Ulitsky I; Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.
Shachar I; Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Dikstein R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 May 07; Vol. 78 (3), pp. 434-444.e5. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Poly A/*genetics
RNA, Messenger/*metabolism
Adenosine/analogs & derivatives ; Animals ; B-Lymphocytes/physiology ; Cells, Cultured ; Female ; Gene Expression Regulation ; Humans ; Internal Ribosome Entry Sites ; MCF-7 Cells ; Mice, Inbred C57BL ; Nuclear Receptor Subfamily 4, Group A, Member 2/genetics ; Nuclear Receptor Subfamily 4, Group A, Member 2/metabolism ; Poly A/metabolism ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA Stability ; RNA, Messenger/genetics ; Receptors, CCR4/genetics ; Receptors, CCR4/metabolism
Czasopismo naukowe
Tytuł :
Ribosome reactivates transcription by physically pushing RNA polymerase out of transcription arrest.
Autorzy :
Stevenson-Jones F; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, NE2 4AX Newcastle Upon Tyne, United Kingdom.
Woodgate J; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, NE2 4AX Newcastle Upon Tyne, United Kingdom.
Castro-Roa D; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, NE2 4AX Newcastle Upon Tyne, United Kingdom.
Zenkin N; Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, NE2 4AX Newcastle Upon Tyne, United Kingdom .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 14; Vol. 117 (15), pp. 8462-8467. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
DNA-Directed RNA Polymerases/*metabolism
Escherichia coli/*enzymology
RNA, Messenger/*metabolism
Ribosomes/*metabolism
Transcriptional Elongation Factors/*metabolism
Base Sequence ; DNA-Directed RNA Polymerases/genetics ; Escherichia coli/genetics ; RNA, Messenger/genetics ; Ribosomes/genetics ; Transcriptional Elongation Factors/genetics
Czasopismo naukowe
Tytuł :
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies.
Autorzy :
Battich N; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands. .
Beumer J; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands.
de Barbanson B; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands.
Krenning L; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands.
Baron CS; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands.
Tanenbaum ME; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands.
Clevers H; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands.
van Oudenaarden A; Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Mar 06; Vol. 367 (6482), pp. 1151-1156.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Stability*
Transcription, Genetic*
RNA, Messenger/*metabolism
Sequence Analysis, RNA/*methods
Single-Cell Analysis/*methods
Animals ; Humans ; Indicators and Reagents/chemistry ; K562 Cells ; Mice ; Uridine/analogs & derivatives
Czasopismo naukowe
Tytuł :
The role of hypoxia on Alzheimer's disease-related APP and Tau mRNA formation.
Autorzy :
Jakubauskienė E; Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
Vilys L; Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
Pečiulienė I; Institute of Biotechnology, Vilnius University, Vilnius, Lithuania.
Kanopka A; Institute of Biotechnology, Vilnius University, Vilnius, Lithuania. Electronic address: .
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Źródło :
Gene [Gene] 2021 Jan 15; Vol. 766, pp. 145146. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid beta-Protein Precursor/*genetics
Cell Hypoxia/*genetics
RNA, Messenger/*genetics
tau Proteins/*genetics
Alternative Splicing/genetics ; Brain/metabolism ; Cell Line, Tumor ; Humans ; Introns/genetics ; RNA Precursors/genetics ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Relative mRNA and protein stability of epigenetic regulators in musculoskeletal cell culture models.
Autorzy :
Badreldin AA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address: .
Bagheri L; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address: .
Zhang B; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Larson AN; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address: .
van Wijnen AJ; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: .
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Źródło :
Gene [Gene] 2021 Jan 15; Vol. 766, pp. 145032. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenesis, Genetic/*genetics
Musculoskeletal System/*metabolism
RNA, Messenger/*genetics
RNA, Messenger/*metabolism
3T3 Cells ; Animals ; Cell Line ; Chromatin/genetics ; Epigenomics/methods ; Histones/genetics ; Mice ; Protein Biosynthesis/genetics ; Protein Stability ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł :
Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation.
Autorzy :
Zhang X; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Chu H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Wen L; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Shuai H; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Yang D; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Wang Y; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Hou Y; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Zhu Z; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Yuan S; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
Yin F; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, People's Republic of China, and The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Pathogen Biology, Hainan Medical University, Haikou, People's Republic of China.; Key Laboratory of Translational Tropical Medicine of Ministry of Education, Hainan Medical University, Haikou, People's Republic of China.
Chan JF; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, People's Republic of China, and The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.
Yuen KY; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 733-746.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Replication*
MicroRNAs/*metabolism
Middle East Respiratory Syndrome Coronavirus/*physiology
RNA, Circular/*metabolism
RNA, Messenger/*metabolism
Cell Line, Tumor ; Gene Expression ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; MicroRNAs/genetics ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; RNA Interference ; RNA, Circular/genetics ; RNA, Messenger/genetics ; RNA, Small Interfering ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells.
Autorzy :
Sikorski PJ; Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland.
Warminski M; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw, Poland.
Kubacka D; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw, Poland.
Ratajczak T; Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland.
Nowis D; Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland.; Department of Genomic Medicine, Medical University of Warsaw, Nielubowicza 5, 02-097 Warsaw, Poland.
Kowalska J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw, Poland.
Jemielity J; Centre of New Technologies, University of Warsaw, Banacha 2C, 02-097 Warsaw, Poland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Feb 28; Vol. 48 (4), pp. 1607-1626.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Protein Biosynthesis/*genetics
RNA Caps/*genetics
RNA, Messenger/*isolation & purification
Animals ; Eukaryota/genetics ; Eukaryotic Initiation Factor-4E/genetics ; Gene Expression Regulation/genetics ; HeLa Cells ; Humans ; Methylation ; Nucleotides/genetics ; Protein Processing, Post-Translational/genetics ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
Autorzy :
Doamekpor SK; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Grudzien-Nogalska E; Dept. Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Mlynarska-Cieslak A; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-093 Warsaw, Poland.
Kowalska J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-093 Warsaw, Poland.
Kiledjian M; Dept. Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Tong L; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 19; Vol. 48 (11), pp. 6136-6148.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Coenzyme A/*metabolism
Exoribonucleases/*metabolism
Flavin-Adenine Dinucleotide/*metabolism
Kluyveromyces/*enzymology
RNA Caps/*metabolism
RNA, Messenger/*chemistry
RNA, Messenger/*metabolism
Schizosaccharomyces pombe Proteins/*metabolism
Animals ; Flavin-Adenine Dinucleotide/analysis ; HEK293 Cells ; Humans ; In Vitro Techniques ; Mice ; Models, Molecular ; NAD/metabolism ; RNA Caps/analysis ; Substrate Specificity ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Measuring transcription at a single gene copy reveals hidden drivers of bacterial individuality.
Autorzy :
Wang M; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.
Zhang J; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
Xu H; School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, China.; Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China.
Golding I; Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA. .; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA. .; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. .
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Źródło :
Nature microbiology [Nat Microbiol] 2019 Dec; Vol. 4 (12), pp. 2118-2127. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Dosage*
Gene Expression Regulation, Bacterial*
Genetic Loci*
Transcription, Genetic*
Escherichia coli/*genetics
RNA, Messenger/*genetics
Cell Cycle/genetics ; RNA, Bacterial/genetics ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Homeostasis in the Central Dogma of molecular biology: the importance of mRNA instability.
Autorzy :
Pérez-Ortín JE; E.R.I. Biotecmed, Universitat de València, Burjassot, Spain.
Tordera V; E.R.I. Biotecmed, Universitat de València, Burjassot, Spain.
Chávez S; Instituto de Biomedicina de Sevilla, Universidad de Sevilla-CSIC-Hospital Universitario Virgen del Rocío. Campus Hospital Universitario Virgen del Rocío, Seville, Spain.
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Źródło :
RNA biology [RNA Biol] 2019 Dec; Vol. 16 (12), pp. 1659-1666. Date of Electronic Publication: 2019 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Stability*
Transcription, Genetic*
DNA/*genetics
Homeostasis/*genetics
Proteins/*genetics
RNA, Messenger/*genetics
DNA/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Evolution, Molecular ; Gene Expression Regulation ; HeLa Cells ; Humans ; Proteins/metabolism ; Proteostasis/genetics ; RNA, Messenger/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism
Czasopismo naukowe
Tytuł :
Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR.
Autorzy :
Danks GB; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway. .
Galbiati H; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway.
Raasholm M; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway.; University of Ulm, Ulm, Germany.
Torres Cleuren YN; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway.; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.
Valen E; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway.; Computational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.
Navratilova P; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway.; Inst Expt Bot, Czech Acad Sci, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
Thompson EM; Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway. .; Department of Biological Sciences, University of Bergen, Bergen, Norway. .
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Źródło :
BMC genomics [BMC Genomics] 2019 Nov 29; Vol. 20 (1), pp. 908. Date of Electronic Publication: 2019 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Protein Biosynthesis*
Trans-Splicing*
Transcription, Genetic*
RNA, Messenger/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Female ; Mammals/genetics ; Nucleotide Motifs ; Oocytes/metabolism ; RNA, Messenger/chemistry ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Urochordata/genetics
Czasopismo naukowe
Tytuł :
A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells.
Autorzy :
So BR; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Di C; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Cai Z; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Venters CC; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Guo J; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Oh JM; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Arai C; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Dreyfuss G; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Nov 21; Vol. 76 (4), pp. 590-599.e4. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
RNA Cleavage*
Transcription, Genetic*
Cell Nucleus/*metabolism
Cleavage And Polyadenylation Specificity Factor/*metabolism
RNA Precursors/*biosynthesis
RNA, Messenger/*biosynthesis
Ribonucleoprotein, U1 Small Nuclear/*metabolism
3' Untranslated Regions ; Active Transport, Cell Nucleus ; Binding Sites ; Cell Nucleus/genetics ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage Stimulation Factor/genetics ; Cleavage Stimulation Factor/metabolism ; HeLa Cells ; Humans ; Multiprotein Complexes ; Poly A/metabolism ; Protein Binding ; RNA Precursors/genetics ; RNA, Messenger/genetics ; Ribonucleoprotein, U1 Small Nuclear/genetics
Czasopismo naukowe
Tytuł :
Regulation of Co-transcriptional Pre-mRNA Splicing by m A through the Low-Complexity Protein hnRNPG.
Autorzy :
Zhou KI; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Medical Scientist Training Program, The University of Chicago, Chicago, IL 60637, USA.
Shi H; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Lyu R; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA.
Wylder AC; Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
Matuszek Ż; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Pan JN; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
He C; Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Institute of Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.
Parisien M; The Alan Edwards Centre for Research on Pain, Department of Dentistry, McGill University, Montréal, QC H3A 0G14, Canada. Electronic address: .
Pan T; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Institute of Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Oct 03; Vol. 76 (1), pp. 70-81.e9. Date of Electronic Publication: 2019 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Transcription, Genetic*
Adenosine/*analogs & derivatives
Heterogeneous-Nuclear Ribonucleoproteins/*metabolism
RNA Precursors/*biosynthesis
RNA, Messenger/*biosynthesis
Adenosine/metabolism ; Amino Acid Motifs ; Binding Sites ; Exons ; HEK293 Cells ; Heterogeneous-Nuclear Ribonucleoproteins/chemistry ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Protein Binding ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA Precursors/genetics ; RNA, Messenger/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.
Autorzy :
Zatreanu D; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Han Z; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Mitter R; Bioinformatics and Biostatistics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Tumini E; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain.
Williams H; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Gregersen L; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Dirac-Svejstrup AB; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Roma S; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain.
Stewart A; Bioinformatics and Biostatistics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Aguilera A; Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Consejo Superior de Investigaciones Científicas-Universidad Pablo de Olavide-Universidad de Sevilla, Seville, Spain.
Svejstrup JQ; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Oct 03; Vol. 76 (1), pp. 57-69.e9. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genomic Instability*
R-Loop Structures*
Stress, Physiological*
Transcription, Genetic*
RNA, Messenger/*genetics
Transcriptional Elongation Factors/*metabolism
Cell Line, Tumor ; HEK293 Cells ; Humans ; Mutation ; RNA Polymerase II/metabolism ; RNA Splicing ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Structure-Activity Relationship ; Transcriptional Elongation Factors/chemistry ; Transcriptional Elongation Factors/genetics
Czasopismo naukowe
Tytuł :
Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA).
Autorzy :
Pillman KA; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.; ACRF Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
Scheer KG; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
Hackett-Jones E; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
Saunders K; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
Bert AG; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
Toubia J; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.; ACRF Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
Whitfield HJ; Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Sapkota S; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
Sourdin L; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.
Pham H; School of Information Technology and Mathematical Sciences, University of South Australia, Mawson Lakes, SA, Australia.
Le TD; School of Information Technology and Mathematical Sciences, University of South Australia, Mawson Lakes, SA, Australia.
Cursons J; School of Information Technology and Mathematical Sciences, University of South Australia, Mawson Lakes, SA, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Davis MJ; School of Information Technology and Mathematical Sciences, University of South Australia, Mawson Lakes, SA, Australia.; Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.; Department of Biochemistry, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Gregory PA; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.; School of Medicine, Discipline of Medicine, University of Adelaide, SA, Australia.
Goodall GJ; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.; School of Medicine, Discipline of Medicine, University of Adelaide, SA, Australia.
Bracken CP; Centre for Cancer Biology, an alliance of SA Pathology and University of South Australia, Adelaide, SA, Australia.; School of Medicine, Discipline of Medicine, University of Adelaide, SA, Australia.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Sep 19; Vol. 47 (16), pp. 8606-8619.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Regulatory Networks*
RNA Processing, Post-Transcriptional*
Transcription, Genetic*
Epithelial-Mesenchymal Transition/*genetics
MicroRNAs/*genetics
RNA, Messenger/*genetics
Cell Line ; Computational Biology/methods ; Datasets as Topic ; Epidermal Growth Factor/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition/drug effects ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Exons ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Introns ; MicroRNAs/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/metabolism ; Signal Transduction ; Transfection ; Transforming Growth Factor beta/pharmacology
Czasopismo naukowe

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