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Wyszukujesz frazę ""Transcription, Genetic"" wg kryterium: Temat


Tytuł :
Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males.
Autorzy :
Wei KH; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Gibilisco L; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Bachtrog D; Department of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 02; Vol. 11 (1), pp. 5537. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Silencing*
Transcription, Genetic*
DNA Transposable Elements/*genetics
Drosophila/*genetics
Y Chromosome/*metabolism
Animals ; Female ; Heterochromatin/metabolism ; Linear Models ; Male ; Models, Genetic ; Mutation ; Sex Factors ; Zygote
Czasopismo naukowe
Tytuł :
Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation.
Autorzy :
Hu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. .
Zhong J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Xiao Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Xing Z; Earth, Planetary and Space Sciences, UCLA, Los Angeles, CA, USA.
Sheu K; Medical Scientist Training Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Fan S; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
An Q; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Qiu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Zheng Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Liu X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Fan G; Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Liu Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 13; Vol. 11 (1), pp. 5148. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
RNA Caps/*genetics
RNA Isoforms/*genetics
Sequence Analysis, RNA/*methods
Humans ; Sequence Analysis, RNA/economics ; Single-Cell Analysis ; Species Specificity ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Autorzy :
Prigozhin DM; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Douse CH; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Farleigh LE; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Albecka A; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Tchasovnikarova IA; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Timms RT; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Oda SI; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Adolf F; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Freund SMV; NMR Facility, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Maslen S; Biological Mass Spectrometry & Proteomics Laboratory, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Lehner PJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
Modis Y; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10313-10328.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Antigens, Neoplasm/*ultrastructure
Nuclear Proteins/*ultrastructure
RNA-Binding Proteins/*chemistry
Antigens, Neoplasm/chemistry ; Antigens, Neoplasm/genetics ; Crystallography, X-Ray ; DNA Transposable Elements/genetics ; Epigenesis, Genetic/genetics ; Gene Silencing ; Humans ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Protein Aggregates/genetics ; Protein Binding/genetics ; Protein Conformation, alpha-Helical ; Protein Domains/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/ultrastructure ; Viruses/genetics
Czasopismo naukowe
Tytuł :
NCBP3 positively impacts mRNA biogenesis.
Autorzy :
Dou Y; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Barbosa I; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
Jiang H; Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Iasillo C; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Molloy KR; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Schulze WM; European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9 38042, France.
Cusack S; European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, Grenoble Cedex 9 38042, France.
Schmid M; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
Le Hir H; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
LaCava J; Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.; European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen 9713 AV, Netherlands.
Jensen TH; Department of Molecular Biology and Genetics, Aarhus University, C.F. Møllers Allé 3, Aarhus 8000, Denmark.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10413-10427.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
RNA/*genetics
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Active Transport, Cell Nucleus/genetics ; Cell Nucleus/genetics ; Exons ; Gene Expression Regulation/genetics ; Humans ; Nuclear Cap-Binding Protein Complex/genetics ; RNA Cap-Binding Proteins/genetics ; RNA Polymerase II/genetics ; RNA Stability/genetics ; RNA Transport/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Replisome bypass of transcription complexes and R-loops.
Autorzy :
Brüning JG; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Marians KJ; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10353-10367.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transcription, Genetic*
DNA Replication/*genetics
DNA-Binding Proteins/*genetics
R-Loop Structures/*genetics
Base Composition/genetics ; Chromosome Structures/genetics ; Chromosomes/genetics ; DNA Helicases/genetics ; DNA Repair/genetics ; Escherichia coli/genetics ; Genomic Instability/genetics
Czasopismo naukowe
Tytuł :
Elements at the 5' end of Xist harbor SPEN-independent transcriptional antiterminator activity.
Autorzy :
Trotman JB; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Lee DM; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, Chapel Hill, NC 27599, USA.
Cherney RE; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, Chapel Hill, NC 27599, USA.
Kim SO; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Inoue K; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Schertzer MD; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, Chapel Hill, NC 27599, USA.
Bischoff SR; Animal Models Core, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.
Cowley DO; Animal Models Core, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.
Calabrese JM; Department of Pharmacology and Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10500-10517.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
DNA-Binding Proteins/*genetics
RNA, Long Noncoding/*genetics
RNA-Binding Proteins/*genetics
X Chromosome Inactivation/*genetics
Animals ; Chromatin/genetics ; Gene Expression Regulation, Developmental/genetics ; Gene Silencing ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Polyadenylation/genetics ; Repetitive Sequences, Nucleic Acid/genetics ; X Chromosome/genetics
Czasopismo naukowe
Tytuł :
Epigenetic silencing of clustered tRNA genes in Arabidopsis.
Autorzy :
Hummel G; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Berr A; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Graindorge S; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Cognat V; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Ubrig E; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Pflieger D; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Molinier J; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
Drouard L; Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, F-67084 Strasbourg, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10297-10312.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Epigenesis, Genetic/*genetics
RNA Polymerase III/*genetics
RNA, Transfer/*genetics
Arabidopsis/genetics ; Cell Nucleus/genetics ; Chromatin/genetics ; Gene Silencing ; Multigene Family/genetics
Czasopismo naukowe
Tytuł :
Pressure regulated basis for gene transcription by delta-cell micro-compliance modeled in silico: Biphenyl, bisphenol and small molecule ligand models of cell contraction-expansion.
Autorzy :
Sarin H; Freelance Investigator in Translational Science and Medicine, Charleston, West Virginia, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Oct 06; Vol. 15 (10), pp. e0236446. Date of Electronic Publication: 2020 Oct 06 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Cell Physiological Phenomena*
Computer Simulation*
Gene Expression Regulation*
Transcription, Genetic*
Benzhydryl Compounds/*metabolism
Biphenyl Compounds/*metabolism
Phenols/*metabolism
Small Molecule Libraries/*metabolism
Algorithms ; Cell Proliferation ; Humans ; Ligands ; Pressure
Czasopismo naukowe
Tytuł :
LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis.
Autorzy :
Chen K; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China. Electronic address: .
Fang H; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China.
Xu N; Department of Orthopaedics, Shanghai Eighth People's Hospital, 14th Floor, Building2, No.8 Caobao Road, Xuhui District, Shanghai 200235, China.
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118095. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Transcription, Genetic*
Histone Demethylases/*metabolism
MicroRNAs/*metabolism
Osteoarthritis/*genetics
Proto-Oncogene Proteins c-jun/*metabolism
RNA, Long Noncoding/*metabolism
Apoptosis/genetics ; Base Sequence ; Cell Proliferation/genetics ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Disease Progression ; Gene Silencing ; Histone Demethylases/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; MicroRNAs/genetics ; Osteoarthritis/pathology ; RNA, Long Noncoding/genetics
Czasopismo naukowe
Tytuł :
Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells.
Autorzy :
Wei F; Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. .
Xu X; Department of Applied Mechanics, Beijing Institute of Technology, 100081, Beijing, China.
Zhang C; Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Liao Y; Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China.
Ji B; Biomechanics and Biomaterials Laboratory, Department of Engineering Mechanics, Zhejiang University, Hangzhou, 310027, Zhejiang, China. .
Wang N; Department of Mechanical Science and Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 29; Vol. 11 (1), pp. 4902. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*chemistry
Stress Fibers/*chemistry
Tetrahydrofolate Dehydrogenase/*genetics
Transcription, Genetic/*physiology
Up-Regulation/*physiology
Animals ; Anisotropy ; Biomechanical Phenomena/genetics ; CHO Cells ; Chromatin/metabolism ; Cricetulus ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Intravital Microscopy ; Microscopy, Fluorescence ; Myosin Type II/antagonists & inhibitors ; Myosin Type II/metabolism ; Stress Fibers/drug effects ; Stress Fibers/metabolism ; Stress, Mechanical ; Transcription, Genetic/drug effects ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.
Autorzy :
Zárate-Potes A; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Yang W; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Pees B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Schalkowski R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Segler P; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Andresen B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Haase D; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Nakad R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Rosenstiel P; Institute for Clinical Molecular Biology (IKMB), Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Tetreau G; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Colletier JP; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Schulenburg H; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Ploen, Germany.
Dierking K; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 24; Vol. 16 (9), pp. e1008826. Date of Electronic Publication: 2020 Sep 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Transcription, Genetic*
Bacillus thuringiensis/*metabolism
Bacterial Infections/*metabolism
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
GATA Transcription Factors/*metabolism
Animals ; Bacillus thuringiensis/pathogenicity ; Bacterial Infections/genetics ; Bacterial Infections/microbiology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/microbiology ; Caenorhabditis elegans Proteins/genetics ; GATA Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency.
Autorzy :
Krasnopolsky S; The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Kuzmina A; The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Taube R; The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 21; Vol. 16 (9), pp. e1008834. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Viral*
Gene Silencing*
Repressor Proteins*/genetics
Repressor Proteins*/metabolism
Transcription Factors*/genetics
Transcription Factors*/metabolism
Transcription, Genetic*
Virus Latency*
CD4-Positive T-Lymphocytes/*metabolism
HIV-1/*physiology
CD4-Positive T-Lymphocytes/virology ; CRISPR-Cas Systems ; Gene Knockout Techniques ; Genome-Wide Association Study ; Humans ; Jurkat Cells ; Promoter Regions, Genetic ; Tripartite Motif-Containing Protein 28/genetics ; Tripartite Motif-Containing Protein 28/metabolism
Czasopismo naukowe
Tytuł :
Uncoupling gene expression noise along the central dogma using genome engineered human cell lines.
Autorzy :
Quarton T; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.
Kang T; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.
Papakis V; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
Nguyen K; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
Nowak C; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
Li Y; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.
Bleris L; Bioengineering Department, University of Texas at Dallas, Richardson, TX, USA.; Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA.; Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 18; Vol. 48 (16), pp. 9406-9413.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Editing*
Transcription, Genetic*
CRISPR-Cas Systems/*genetics
Genome, Human/*genetics
Cell Line ; Gene Expression Regulation/genetics ; Humans ; Models, Genetic ; Protein Biosynthesis/genetics ; Stochastic Processes
Czasopismo naukowe
Tytuł :
Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains.
Autorzy :
Smalakyte D; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Kazlauskiene M; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
F Havelund J; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark.
Rukšėnaitė A; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Rimaite A; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Tamulaitiene G; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Færgeman NJ; Department of Biochemistry and Molecular Biology, VILLUM Center for Bioanalytical Sciences, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark.
Tamulaitis G; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
Siksnys V; Institute of Biotechnology, Vilnius University, Saulėtekio av. 7, LT-10257 Vilnius, Lithuania.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 18; Vol. 48 (16), pp. 9204-9217.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems/*genetics
Immunity/*genetics
Streptococcus thermophilus/*genetics
Transcription, Genetic/*genetics
Chromatography, High Pressure Liquid ; Endonucleases/genetics ; Escherichia coli/genetics ; Escherichia coli/immunology ; Protein Domains/genetics ; RNA Stability/genetics ; RNA Stability/immunology ; Ribonucleases/genetics ; Signal Transduction/genetics ; Streptococcus thermophilus/immunology ; Transcription, Genetic/immunology
Czasopismo naukowe
Tytuł :
Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis.
Autorzy :
Shuman S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8243-8254.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gene Expression Regulation, Fungal*
Transcription, Genetic*
RNA, Long Noncoding/*genetics
Saccharomycetales/*genetics
Schizosaccharomyces/*genetics
Homeostasis ; Nutrients/metabolism ; Phosphoglycerate Dehydrogenase/genetics ; Phosphoglycerate Dehydrogenase/metabolism ; RNA, Messenger ; Regulon ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomycetales/metabolism ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism
Czasopismo naukowe
Tytuł :
NC2 complex is a key factor for the activation of catalase-3 transcription by regulating H2A.Z deposition.
Autorzy :
Cui G; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Dong Q; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Duan J; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Zhang C; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Liu X; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; College of Life Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China.
He Q; State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8332-8348.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Catalase/*genetics
Phosphoproteins/*genetics
Transcription Factors/*genetics
Cell Nucleus/genetics ; Chromatin Assembly and Disassembly/genetics ; Gene Expression Regulation/genetics ; Genes, MHC Class II/genetics ; Histones/genetics ; Neurospora crassa/genetics ; Nucleosomes/genetics ; Nucleosomes/ultrastructure ; Phosphoproteins/ultrastructure ; Protein Binding/genetics ; Transcription Factors/ultrastructure ; Transcriptional Activation/genetics
Czasopismo naukowe
Tytuł :
Chromatin remodeler Ino80C acts independently of H2A.Z to evict promoter nucleosomes and stimulate transcription of highly expressed genes in yeast.
Autorzy :
Qiu H; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Biernat E; Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA.
Govind CK; Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA.
Rawal Y; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Chereji RV; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Clark DJ; Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Hinnebusch AG; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8408-8430.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Histones/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Transcriptional Activation/*genetics
Adenosine Triphosphatases/genetics ; Chromatin/genetics ; Chromatin Assembly and Disassembly/genetics ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Fungal/genetics ; Nucleosomes/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/chemistry ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Embryonic tissue differentiation is characterized by transitions in cell cycle dynamic-associated core promoter regulation.
Autorzy :
Wragg JW; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Roos L; Institute of Clinical Sciences and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Vucenovic D; Institute of Clinical Sciences and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Cvetesic N; Institute of Clinical Sciences and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Lenhard B; Institute of Clinical Sciences and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Müller F; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8374-8392.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Initiation Site*
Transcription, Genetic*
Gene Regulatory Networks/*genetics
Promoter Regions, Genetic/*genetics
Animals ; Binding Sites/genetics ; Cell Cycle/genetics ; Cell Differentiation/genetics ; Cell Proliferation/genetics ; Embryonic Development/genetics ; Humans ; Morphogenesis/genetics ; Sp1 Transcription Factor/genetics ; TATA Box/genetics ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing.
Autorzy :
Amante SM; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Montibus B; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Cowley M; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Barkas N; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Setiadi J; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Saadeh H; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Giemza J; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Contreras-Castillo S; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Fleischanderl K; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Schulz R; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
Oakey RJ; Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London SE1 9RT, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Sep 04; Vol. 48 (15), pp. 8349-8359.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Transcription, Genetic*
Protein Processing, Post-Translational/*genetics
RNA Precursors/*genetics
Animals ; Cell Differentiation/genetics ; Chromatin/genetics ; CpG Islands/genetics ; DNA Methylation/genetics ; Genome/genetics ; Histone Code/genetics ; Humans ; Promoter Regions, Genetic ; Pseudogenes/genetics ; RNA Precursors/metabolism
Czasopismo naukowe
Tytuł :
Phosphorylation controls RNA binding and transcription by the influenza virus polymerase.
Autorzy :
Dawson AR; Department of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, United States of America.
Wilson GM; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, United States of America.
Freiberger EC; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, United States of America.
Mondal A; Department of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, United States of America.
Coon JJ; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, United States of America.; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, United States of America.
Mehle A; Department of Medical Microbiology & Immunology, University of Wisconsin-Madison, Madison, WI, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 03; Vol. 16 (9), pp. e1008841. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Virus Replication*
Influenza A virus/*physiology
RNA, Viral/*biosynthesis
Viral Proteins/*metabolism
A549 Cells ; Animals ; Dogs ; HEK293 Cells ; Humans ; Madin Darby Canine Kidney Cells ; Phosphorylation ; RNA, Viral/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Identification of the human DPR core promoter element using machine learning.
Autorzy :
Vo Ngoc L; Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Huang CY; Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Cassidy CJ; Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Medrano C; Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Kadonaga JT; Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7825), pp. 459-463. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Support Vector Machine*
Transcription, Genetic*
Consensus Sequence/*genetics
Gene Expression Regulation/*genetics
Promoter Regions, Genetic/*genetics
RNA Polymerase II/*metabolism
Base Sequence ; Cells/metabolism ; Computer Simulation ; Datasets as Topic ; HeLa Cells ; High-Throughput Nucleotide Sequencing ; Humans ; Models, Genetic ; Mutagenesis ; TATA Box/genetics
Czasopismo naukowe
Tytuł :
A Practicable Method of Tuning the Noise Intensity at Protein Level.
Autorzy :
Lo SC; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei City, Taiwan.
You CX; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei City, Taiwan.
Shu CC; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei City, Taiwan.
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Źródło :
Journal of computational biology : a journal of computational molecular cell biology [J Comput Biol] 2020 Sep; Vol. 27 (9), pp. 1452-1460. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Theoretical*
Protein Biosynthesis*
Transcription, Genetic*
Animals ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Signal-To-Noise Ratio ; Stochastic Processes
Czasopismo naukowe
Tytuł :
Functionally uncoupled transcription-translation in Bacillus subtilis.
Autorzy :
Johnson GE; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lalanne JB; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Peters ML; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Li GW; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7823), pp. 124-128. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Bacterial*
Protein Biosynthesis*
Transcription, Genetic*
Bacillus subtilis/*genetics
5' Untranslated Regions/genetics ; Bacillus subtilis/enzymology ; Bacillus subtilis/metabolism ; DNA-Directed RNA Polymerases/metabolism ; Phylogeny ; RNA, Bacterial/biosynthesis ; RNA, Bacterial/metabolism ; RNA, Messenger/biosynthesis ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Rho Factor/metabolism ; Ribosomes/metabolism ; Riboswitch/genetics
Czasopismo naukowe
Tytuł :
The roles of replication-transcription conflict in mutagenesis and evolution of genome organization.
Autorzy :
Schroeder JW; Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Sankar TS; School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala, India.
Wang JD; Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Simmons LA; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Aug 27; Vol. 16 (8), pp. e1008987. Date of Electronic Publication: 2020 Aug 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Evolution, Molecular*
Transcription, Genetic*
DNA Replication/*genetics
Selection, Genetic/*genetics
Bacteria/genetics ; Genome, Bacterial/genetics
Czasopismo naukowe
Tytuł :
JMJD5 couples with CDK9 to release the paused RNA polymerase II.
Autorzy :
Liu H; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Ramachandran S; RNA Bioscience Initiative and Department of Genetics and Biochemistry, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Fong N; RNA Bioscience Initiative and Department of Genetics and Biochemistry, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Phang T; Department of Biostatistics and Informatics, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Lee S; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Parsa P; NanoTemper Technologies, Inc., South San Francisco, CA 94080.
Liu X; Department of Hematology, Duke University, Durham, NC 27710.
Harmacek L; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Danhorn T; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Song T; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Oh S; Department of Cell Biology, University of Oklahoma, Oklahoma City, OK 73104.
Zhang Q; School of Life Science, China Agricultural University, 100101 Beijing, People's Republic of China.
Chen Z; School of Life Science, China Agricultural University, 100101 Beijing, People's Republic of China.
Zhang Q; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
Tu TH; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Happoldt C; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
O'Conner B; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Janknecht R; Department of Cell Biology, University of Oklahoma, Oklahoma City, OK 73104.
Li CY; Department of Hematology, Duke University, Durham, NC 27710.
Marrack P; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Kappler J; Department of Biomedical Research, National Jewish Health, Denver, CO 80206; .; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
Leach S; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.
Zhang G; Department of Biomedical Research, National Jewish Health, Denver, CO 80206; .; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80216.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 18; Vol. 117 (33), pp. 19888-19895. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Cyclin-Dependent Kinase 9/*metabolism
Histone Demethylases/*metabolism
RNA Polymerase II/*metabolism
Cell Line, Tumor ; Cyclin-Dependent Kinase 9/genetics ; Histone Demethylases/chemistry ; Histone Demethylases/genetics ; Humans ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Phosphorylation ; Positive Transcriptional Elongation Factor B/genetics ; Positive Transcriptional Elongation Factor B/metabolism ; Promoter Regions, Genetic ; Protein Binding ; Protein Domains ; RNA Polymerase II/genetics
Czasopismo naukowe

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