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Tytuł:
Identification AAVS1 -like locus from the porcine genome and site-specific integration of recombinase-mediated cassette exchange using CRISPR/Cas9.
Autorzy:
Yum SY; Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul, Republic of Korea.; LARTBio Incorp, Seoul, Republic of Korea.
Choi W; Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul, Republic of Korea.
Kim S; ToolGen, Inc, Seoul, South Korea.
Jang G; Laboratory of Theriogenology and Biotechnology, Department of Veterinary Clinical Science, College of Veterinary Medicine and the Research Institute of Veterinary Science, Seoul National University, Seoul, Republic of Korea.; LARTBio Incorp, Seoul, Republic of Korea.; BK21 Plus program, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.; Institute of Green Bio Science Technology, Seoul National University, Pyeongchang-gun, Republic of Korea.; Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
Koo O; ToolGen, Inc, Seoul, South Korea.; nSAGE Inc., Incheon, South Korea.; SeaWith Inc., Daegu, South Korea.
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Źródło:
Animal biotechnology [Anim Biotechnol] 2023 Dec; Vol. 34 (9), pp. 4730-4735. Date of Electronic Publication: 2023 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
Recombinases*/genetics
Recombinases*/metabolism
CRISPR-Cas Systems*/genetics
Animals ; Swine/genetics ; Humans ; Mice ; Transcription Activator-Like Effector Nucleases/genetics ; Transcription Activator-Like Effector Nucleases/metabolism ; Animals, Genetically Modified/metabolism ; Gene Targeting
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Editing of ORF138 restores fertility of Ogura cytoplasmic male sterile broccoli via mitoTALENs.
Autorzy:
Xu F; Hainan Institute, Zhejiang University, Yazhou Bay Science and Technology City, Sanya, China.; Laboratory of Germplasm Innovation and Molecular Breeding, Institute of Vegetable Science, Zhejiang University, Hangzhou, China.
Su T; Beijing Vegetable Research Center, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Zhang X; Hainan Institute, Zhejiang University, Yazhou Bay Science and Technology City, Sanya, China.
Qiu L; College of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, China.
Yang X; College of Horticulture and Landscape Architecture, Yangzhou University, Yangzhou, China.
Koizuka N; College of Agriculture, Tamagawa University, Tokyo, Japan.
Arimura SI; Laboratory of Plant Molecular Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Hu Z; Hainan Institute, Zhejiang University, Yazhou Bay Science and Technology City, Sanya, China.; Laboratory of Germplasm Innovation and Molecular Breeding, Institute of Vegetable Science, Zhejiang University, Hangzhou, China.; Key Laboratory of Horticultural Plant Growth and Development, Ministry of Agriculture and Rural Affairs, Hangzhou, China.
Zhang M; Hainan Institute, Zhejiang University, Yazhou Bay Science and Technology City, Sanya, China.; Laboratory of Germplasm Innovation and Molecular Breeding, Institute of Vegetable Science, Zhejiang University, Hangzhou, China.; Key Laboratory of Horticultural Plant Growth and Development, Ministry of Agriculture and Rural Affairs, Hangzhou, China.
Yang J; Hainan Institute, Zhejiang University, Yazhou Bay Science and Technology City, Sanya, China.; Laboratory of Germplasm Innovation and Molecular Breeding, Institute of Vegetable Science, Zhejiang University, Hangzhou, China.; Key Laboratory of Horticultural Plant Growth and Development, Ministry of Agriculture and Rural Affairs, Hangzhou, China.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2024 May; Vol. 22 (5), pp. 1325-1334. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Brassica*/genetics
Infertility, Male*
Male ; Humans ; Transcription Activator-Like Effector Nucleases ; Plant Breeding ; Mitochondria/genetics ; Fertility/genetics ; Plant Infertility/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide specificity of plant genome editing by both CRISPR-Cas9 and TALEN.
Autorzy:
Bessoltane N; Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000, Versailles, France.
Charlot F; Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000, Versailles, France.
Guyon-Debast A; Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000, Versailles, France.
Charif D; Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000, Versailles, France.
Mara K; CSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, VIC, 3220, Australia.
Collonnier C; Community Plant Variety Office (CPVO), 49101, Angers, France.
Perroud PF; Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000, Versailles, France.
Tepfer M; Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000, Versailles, France.
Nogué F; Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000, Versailles, France. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jun 04; Vol. 12 (1), pp. 9330. Date of Electronic Publication: 2022 Jun 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Editing*/methods
Transcription Activator-Like Effector Nucleases*/genetics
CRISPR-Cas Systems/genetics ; Genome, Plant/genetics ; Plants/genetics ; Plants, Genetically Modified/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome editing with removable TALEN vectors harboring a yeast centromere and autonomous replication sequence in oleaginous microalga.
Autorzy:
Kurita T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan.
Iwai M; School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-65 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8501, Japan.
Moroi K; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan.
Okazaki K; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan.
Nomura S; Mazda Motor Corporation, 3-1 Shinchi, Fuchu-cho, Aki-gun, Hiroshima, 730-8670, Japan.
Saito F; Mazda Motor Corporation, 3-1 Shinchi, Fuchu-cho, Aki-gun, Hiroshima, 730-8670, Japan.
Maeda S; Mazda Motor Corporation, 3-1 Shinchi, Fuchu-cho, Aki-gun, Hiroshima, 730-8670, Japan.
Takami A; Mazda Motor Corporation, 3-1 Shinchi, Fuchu-cho, Aki-gun, Hiroshima, 730-8670, Japan.
Sakamoto A; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan.
Ohta H; School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-65 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8501, Japan.
Sakuma T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan.
Yamamoto T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8526, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 15; Vol. 12 (1), pp. 2480. Date of Electronic Publication: 2022 Feb 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Vectors*
Transcription Activator-Like Effector Nucleases*
Centromere/*genetics
DNA Replication/*genetics
Gene Editing/*methods
Microalgae/*genetics
Microalgae/*metabolism
Sequence Analysis, DNA/*methods
Carbon Dioxide/metabolism ; Feasibility Studies ; Lipid Metabolism/genetics ; Organisms, Genetically Modified ; Plasmids ; Transgenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks.
Autorzy:
Benjamin R; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.; School of Life Science, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Banerjee A; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.; School of Life Science, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Wu X; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Geurink C; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.; School of Life Science, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Buczek L; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.; School of Life Science, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Eames D; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.; School of Life Science, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Trimidal SG; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.; School of Life Science, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Pluth JM; Health Physics and Diagnostic Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Schiller MR; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.; School of Life Science, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 06; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Breaks, Double-Stranded*
DNA Repair*
RNA-Seq*
DNA-Binding Proteins/*genetics
MRE11 Homologue Protein/*genetics
Transcription Activator-Like Effector Nucleases/*toxicity
DNA/metabolism ; Gene Knockout Techniques ; HeLa Cells ; Humans ; MRE11 Homologue Protein/antagonists & inhibitors ; Transcription Activator-Like Effector Nucleases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric Fok I Nuclease Domains.
Autorzy:
Smith T; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Singh P; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Chmielewski KO; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg & Medical Faculty, University of Freiburg, 79106 Freiburg, Germany.
Bloom K; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg & Medical Faculty, University of Freiburg, 79106 Freiburg, Germany.
Arbuthnot P; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
Ely A; Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown 2193, South Africa.
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Źródło:
Viruses [Viruses] 2021 Jul 12; Vol. 13 (7). Date of Electronic Publication: 2021 Jul 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatitis B/*drug therapy
Hepatitis B virus/*genetics
Transcription Activator-Like Effector Nucleases/*genetics
Animals ; Animals, Outbred Strains ; Antiviral Agents/therapeutic use ; Cell Line ; DNA Viruses/genetics ; DNA, Circular ; DNA, Viral/genetics ; Deoxyribonucleases, Type II Site-Specific/genetics ; Deoxyribonucleases, Type II Site-Specific/metabolism ; Disease Models, Animal ; Endonucleases/genetics ; Female ; Genetic Therapy/methods ; HEK293 Cells ; Hep G2 Cells ; Hepatitis B/genetics ; Hepatitis B/immunology ; Hepatitis B, Chronic/genetics ; Hepatitis B, Chronic/virology ; Humans ; Mice ; Transcription Activator-Like Effector Nucleases/therapeutic use ; Virus Replication/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-Efficiency CRISPR/Cas9-Mediated Correction of a Homozygous Mutation in Achromatopsia-Patient-Derived iPSCs.
Autorzy:
Siles L; Fundació de Recerca de l'Institut de Microcirurgia Ocular, 08035 Barcelona, Spain.; Departament de Genètica, IMO Grupo Miranza, 08035 Barcelona, Spain.
Gaudó P; Fundació de Recerca de l'Institut de Microcirurgia Ocular, 08035 Barcelona, Spain.; Departament de Genètica, IMO Grupo Miranza, 08035 Barcelona, Spain.
Pomares E; Fundació de Recerca de l'Institut de Microcirurgia Ocular, 08035 Barcelona, Spain.; Departament de Genètica, IMO Grupo Miranza, 08035 Barcelona, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 11; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Color Vision Defects*/genetics
Color Vision Defects*/therapy
CRISPR-Cas Systems*
Gene Editing*/methods
Humans ; Mutation ; Transcription Activator-Like Effector Nucleases/genetics ; Induced Pluripotent Stem Cells
SCR Disease Name:
Achromatopsia 3
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficient and multiplexable genome editing using Platinum TALENs in oleaginous microalga, Nannochloropsis oceanica NIES-2145.
Autorzy:
Kurita T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Moroi K; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Iwai M; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Okazaki K; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Shimizu S; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Nomura S; Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan.
Saito F; Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan.
Maeda S; Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan.
Takami A; Mazda Motor Corporation, Fuchu-cho, Hiroshima, Japan.
Sakamoto A; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Ohta H; School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Sakuma T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Yamamoto T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2020 Oct; Vol. 25 (10), pp. 695-702. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Editing/*methods
Microalgae/*genetics
Transcription Activator-Like Effector Nucleases/*metabolism
Gene Expression ; HEK293 Cells ; Humans ; Lipid Metabolism/genetics ; Lipids/genetics ; Microalgae/metabolism ; Plasmids/genetics ; Stramenopiles/genetics ; Stramenopiles/metabolism ; Transcription Activator-Like Effector Nucleases/genetics ; Transfection/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Disruption of miRNA sequences by TALENs and CRISPR/Cas9 induces varied lengths of miRNA production.
Autorzy:
Bi H; Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.
Fei Q; Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA.; Donald Danforth Plant Science Center, St. Louis, MO, USA.
Li R; Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.; Division of Plant Sciences, University of Missouri, Columbia, MO, USA.
Liu B; Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.; Division of Plant Sciences, University of Missouri, Columbia, MO, USA.
Xia R; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, China.
Char SN; Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.
Meyers BC; Donald Danforth Plant Science Center, St. Louis, MO, USA.; Division of Plant Sciences, University of Missouri, Columbia, MO, USA.
Yang B; Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.; Donald Danforth Plant Science Center, St. Louis, MO, USA.; Division of Plant Sciences, University of Missouri, Columbia, MO, USA.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2020 Jul; Vol. 18 (7), pp. 1526-1536. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
MicroRNAs*/genetics
Transcription Activator-Like Effector Nucleases*
CRISPR-Cas Systems/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats ; Gene Editing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CRISPR-Cas9 Technology for the Creation of Biological Avatars Capable of Modeling and Treating Pathologies: From Discovery to the Latest Improvements.
Autorzy:
Nasrallah A; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Sulpice E; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Kobaisi F; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Gidrol X; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Rachidi W; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
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Źródło:
Cells [Cells] 2022 Nov 15; Vol. 11 (22). Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
CRISPR-Cas Systems*/genetics
Gene Editing*
Humans ; Zinc Finger Nucleases ; Transcription Activator-Like Effector Nucleases/genetics ; Technology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Efficient TALEN-mediated gene editing in wheat.
Autorzy:
Luo M; CSIRO Agriculture and Food, Canberra, ACT, Australia.
Li H; CSIRO Agriculture and Food, Canberra, ACT, Australia.
Chakraborty S; CSIRO Agriculture and Food, Canberra, ACT, Australia.
Morbitzer R; Eberhard Karls Universität Tübingen, ZMBP, Allgemeine Genetik, Tübingen, Germany.
Rinaldo A; CSIRO Agriculture and Food, Canberra, ACT, Australia.; The Australian Wine Research Institute, Glen Osmond, South Australia, Australia.
Upadhyaya N; CSIRO Agriculture and Food, Canberra, ACT, Australia.
Bhatt D; CSIRO Agriculture and Food, Canberra, ACT, Australia.
Louis S; CSIRO Agriculture and Food, Canberra, ACT, Australia.
Richardson T; CSIRO Agriculture and Food, Canberra, ACT, Australia.
Lahaye T; Eberhard Karls Universität Tübingen, ZMBP, Allgemeine Genetik, Tübingen, Germany.
Ayliffe M; CSIRO Agriculture and Food, Canberra, ACT, Australia.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2019 Nov; Vol. 17 (11), pp. 2026-2028. Date of Electronic Publication: 2019 Jun 06.
Typ publikacji:
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Editing*
Transcription Activator-Like Effector Nucleases*
Triticum/*genetics
Plants, Genetically Modified
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Potential Application of TALENs against Murine Cytomegalovirus Latent Infections.
Autorzy:
Chen SJ; Department of Neurosurgery, Mackay Memorial Hospital, Taipei 10449, Taiwan. .; Department of Medicine, Mackay Medicine College, New Taipei City 25245, Taiwan. .
Chen YC; Comparative Biochemistry program, University of California, Berkeley, CA 94720, USA. .; National Applied Research Laboratories, Taipei 10636, Taiwan. .
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Źródło:
Viruses [Viruses] 2019 May 03; Vol. 11 (5). Date of Electronic Publication: 2019 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Latency*
Cytomegalovirus/*physiology
Cytomegalovirus Infections/*enzymology
Herpesviridae Infections/*enzymology
Herpesviridae Infections/*virology
Muromegalovirus/*physiology
Transcription Activator-Like Effector Nucleases/*metabolism
Animals ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/virology ; Disease Models, Animal ; Herpesviridae Infections/genetics ; Humans ; Mice ; Mice, Inbred BALB C ; Muromegalovirus/genetics ; Muromegalovirus/growth & development ; Transcription Activator-Like Effector Nucleases/genetics ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Spontaneous, Artificial, and Genome Editing-Mediated Mutations in Prunus .
Autorzy:
Prudencio AS; Department of Plant Breeding, Centro de Edafología y Biología Apliacada del Segura-Consejo Superior de Investigaciones Científicas (CEBAS-CSIC), 30100 Espinardo, Spain.
Devin SR; Department of Horticultural Science, College of Agriculture, Shiraz University, Shiraz 7144165186, Iran.
Mahdavi SME; Department of Horticultural Science, College of Agriculture, Shiraz University, Shiraz 7144165186, Iran.
Martínez-García PJ; Department of Plant Breeding, Centro de Edafología y Biología Apliacada del Segura-Consejo Superior de Investigaciones Científicas (CEBAS-CSIC), 30100 Espinardo, Spain.
Salazar JA; Department of Plant Breeding, Centro de Edafología y Biología Apliacada del Segura-Consejo Superior de Investigaciones Científicas (CEBAS-CSIC), 30100 Espinardo, Spain.
Martínez-Gómez P; Department of Plant Breeding, Centro de Edafología y Biología Apliacada del Segura-Consejo Superior de Investigaciones Científicas (CEBAS-CSIC), 30100 Espinardo, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Oct 31; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Gene Editing*
Prunus*/genetics
Prunus*/metabolism
Animals ; CRISPR-Cas Systems/genetics ; Transcription Activator-Like Effector Nucleases/genetics ; Plant Breeding ; Mutation ; Endonucleases/metabolism ; Genome, Plant
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Therapeutic Application of Genome Editing Technologies in Viral Diseases.
Autorzy:
Kim TH; Department of Molecular Biology, Dankook University, Cheonan 31116, Korea.
Lee SW; Department of Bioconvergence Engineering, Research Institute of Advanced Omics, Dankook University, Yongin 16890, Korea.; R&D Center, Rznomics Inc., Seongnam 13486, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 12; Vol. 23 (10). Date of Electronic Publication: 2022 May 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Gene Editing*
Virus Diseases*/genetics
Virus Diseases*/therapy
Genome ; Humans ; Technology ; Transcription Activator-Like Effector Nucleases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment of β -thalassaemia by TALENs in a mouse model.
Autorzy:
Fang Y; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Department of Histo-Embryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Cheng Y; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Department of Histo-Embryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.; Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lu D; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Gong X; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Yang G; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Gong Z; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Zhu Y; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Sang X; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Fan S; Department of Histo-Embryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang J; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
Zeng F; Shanghai Children's Hospital, Shanghai Institute of Medical Genetics, Shanghai Jiao Tong University, Shanghai, China.; Department of Histo-Embryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Key Laboratory of Embryo Molecular Biology, Ministry of Health & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.; Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło:
Cell proliferation [Cell Prolif] 2018 Dec; Vol. 51 (6), pp. e12491. Date of Electronic Publication: 2018 Aug 02.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Therapy*/methods
Transcription Activator-Like Effector Nucleases/*genetics
beta-Globins/*genetics
beta-Thalassemia/*therapy
Animals ; Disease Models, Animal ; Gene Targeting/methods ; Mice, Transgenic ; Mutation/genetics ; Phenotype ; Transcription Activator-Like Effector Nucleases/metabolism ; beta-Thalassemia/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Establishment of CRFK cells for vaccine production by inactivating endogenous retrovirus with TALEN technology.
Autorzy:
Shimode S; Genome Editing Innovation Center, Hiroshima University, Higashi-Hiroshima, Japan.; Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Sakuma T; Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Yamamoto T; Genome Editing Innovation Center, Hiroshima University, Higashi-Hiroshima, Japan.; Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Miyazawa T; Laboratory of Virus-Host Coevolution, Research Center for Infectious Diseases, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 27; Vol. 12 (1), pp. 6641. Date of Electronic Publication: 2022 Apr 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endogenous Retroviruses*/genetics
Animals ; Cats ; Kidney ; Technology ; Transcription Activator-Like Effector Nucleases/genetics ; Transcription Activator-Like Effectors/genetics ; Vaccines, Attenuated
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CRISPR based therapeutics: a new paradigm in cancer precision medicine.
Autorzy:
Das S; National Centre for Cell Science, S P Pune University Campus, Pune, 411007, India.
Bano S; National Centre for Cell Science, S P Pune University Campus, Pune, 411007, India.
Kapse P; School of Basic Medical Sciences, S P Pune University, Pune, 411007, India.
Kundu GC; Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed To Be University, Bhubaneswar, 751024, India. .; School of Biotechnology, KIIT Deemed To Be University, Bhubaneswar, 751024, India. .
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Źródło:
Molecular cancer [Mol Cancer] 2022 Mar 25; Vol. 21 (1), pp. 85. Date of Electronic Publication: 2022 Mar 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Neoplasms*/genetics
Neoplasms*/therapy
Precision Medicine*
CRISPR-Cas Systems ; Gene Editing ; Humans ; Transcription Activator-Like Effector Nucleases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recent Advances in the Production of Genome-Edited Rats.
Autorzy:
Sato M; Department of Genome Medicine, National Center for Child Health and Development, Tokyo 157-8535, Japan.
Nakamura S; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Inada E; Department of Pediatric Dentistry, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Takabayashi S; Laboratory Animal Facilities & Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 25; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Cas Systems*/genetics
Nucleic Acids*
Animals ; Female ; Gene Editing/methods ; Genome/genetics ; Humans ; Rats ; Transcription Activator-Like Effector Nucleases/genetics ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of ITGA2B Promoter-Driven BDDF8 Gene in Hemophilia A.
Autorzy:
Zhao J; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Zhou M; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Wang Z; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Wu L; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Hu Z; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
Liang D; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 06; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Ectopic Gene Expression*
Promoter Regions, Genetic*
Factor VIII/*genetics
Hematopoietic Stem Cells/*metabolism
Hemophilia A/*genetics
Induced Pluripotent Stem Cells/*metabolism
Integrin alpha2/*genetics
Mesenchymal Stem Cells/*metabolism
Base Sequence ; DNA, Ribosomal/genetics ; Factor VIII/chemistry ; Factor VIII/metabolism ; Gene Targeting ; Genetic Loci ; Genetic Vectors/metabolism ; Humans ; Integrin alpha2/metabolism ; Megakaryocytes/metabolism ; Protein Domains ; Sequence Deletion ; Transcription Activator-Like Effector Nucleases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish.
Autorzy:
Raby L; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
Völkel P; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
Hasanpour S; Department of Fisheries and Animal Sciences, Faculty of Natural Resources, University of Tehran, Karaj 31587-77871, Iran.
Cicero J; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.; Univ. Artois, UR 2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), F-62300 Lens, France.
Toillon RA; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
Adriaenssens E; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
Van Seuningen I; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
Le Bourhis X; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
Angrand PO; Univ. Lille, CNRS, Inserm, CHU Lille, UMR 9020-U 1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
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Źródło:
Cells [Cells] 2021 Nov 12; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Homeostasis*
Digestive System/*metabolism
Neurons/*cytology
Polycomb Repressive Complex 2/*deficiency
Zebrafish/*metabolism
Animals ; Animals, Genetically Modified ; Behavior, Animal ; Cell Differentiation ; Gene Expression Regulation, Developmental ; Histones/metabolism ; Larva/metabolism ; Liver/metabolism ; Lysine/metabolism ; Methylation ; Motor Activity ; Mutation/genetics ; Neurons/metabolism ; Organ Specificity ; Polycomb Repressive Complex 2/metabolism ; Protein Processing, Post-Translational ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription Activator-Like Effector Nucleases/metabolism ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 274

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