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Wyszukujesz frazę ""Transcription Factor HES-1"" wg kryterium: Temat


Tytuł :
O-linked N-acetylglucosaminyltransferase OGT inhibits diabetic nephropathy by stabilizing histone methyltransferases EZH2 via the HES1/PTEN axis.
Autorzy :
Fang N; Department of Nephrology, The Fifth People's Hospital of Jinan, Jinan 250022, PR China. Electronic address: .
Li P; Special Inspection Section, The Fifth People's Hospital of Jinan, Jinan 250022, PR China.
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Źródło :
Life sciences [Life Sci] 2021 Jun 01; Vol. 274, pp. 119226. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*complications
Diabetic Nephropathies/*prevention & control
Enhancer of Zeste Homolog 2 Protein/*chemistry
N-Acetylglucosaminyltransferases/*metabolism
PTEN Phosphohydrolase/*metabolism
Transcription Factor HES-1/*metabolism
Animals ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Down-Regulation ; Enzyme Stability ; Male ; Mice ; Mice, Inbred C57BL ; N-Acetylglucosaminyltransferases/genetics ; PTEN Phosphohydrolase/genetics ; Transcription Factor HES-1/genetics
Czasopismo naukowe
Tytuł :
IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor.
Autorzy :
Kim B; Department of Medicine, The Graduate School, Yonsei University College of Medicine, Seoul, Korea.; Division of Translational Science, Center for Colon Cancer, Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea.; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Seo Y; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kwon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Shin Y; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kim S; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Park SJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Park JJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Yonsei University College of Medicine, Seoul, Korea.
Cheon JH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Kim WH; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Il Kim T; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.; Yonsei Cancer Prevention Center, Yonsei University College of Medicine, Seoul, Korea.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2021 Mar; Vol. 60 (3), pp. 188-200. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*pathology
Interleukin-6/*metabolism
Interleukin-8/*metabolism
Neoplastic Stem Cells/*pathology
Transcription Factor HES-1/*metabolism
Caco-2 Cells ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Culture Media, Conditioned/pharmacology ; Gene Expression Regulation, Neoplastic ; Humans ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Organoids/pathology ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Transcription Factor HES-1/genetics ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Foxi1 inactivation rescues loss of principal cell fate selection in Hes1-deficient kidneys but does not ensure maintenance of principal cell gene expression.
Autorzy :
Mukherjee M; Sanford Research, 2301 East 60th Street North, Sioux Falls, SD, 57104, USA.
DeRiso J; Sanford Research, 2301 East 60th Street North, Sioux Falls, SD, 57104, USA.
Janga M; Sanford Research, 2301 East 60th Street North, Sioux Falls, SD, 57104, USA.
Fogarty E; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 57069, SD, USA.
Surendran K; Sanford Research, 2301 East 60th Street North, Sioux Falls, SD, 57104, USA; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, 57104, USA. Electronic address: .
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Źródło :
Developmental biology [Dev Biol] 2020 Oct 01; Vol. 466 (1-2), pp. 1-11. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Developmental*
Signal Transduction*
Forkhead Transcription Factors/*metabolism
Kidney/*embryology
Receptors, Notch/*metabolism
Transcription Factor HES-1/*deficiency
Animals ; Forkhead Transcription Factors/genetics ; Mice ; Mice, Mutant Strains ; Receptors, Notch/genetics ; Transcription Factor HES-1/metabolism
Czasopismo naukowe
Tytuł :
Visualizing Cell Cycle Phase Organization and Control During Neural Lineage Elaboration.
Autorzy :
Urun FR; Laboratory for Neurodiversity, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.; Graduate School of Science and Engineering, Saitama University, Sakura-ku, Saitama 338-8570, Japan.
Moore AW; Laboratory for Neurodiversity, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
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Źródło :
Cells [Cells] 2020 Sep 17; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Developmental*
Cyclin-Dependent Kinase Inhibitor p27/*genetics
Neural Stem Cells/*metabolism
Olfactory Mucosa/*metabolism
Olfactory Receptor Neurons/*metabolism
Transcription Factor HES-1/*genetics
Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Cycle/genetics ; Cell Differentiation ; Cell Lineage/genetics ; Cell Tracking/methods ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Embryo, Mammalian ; Genes, Reporter ; Humans ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mice ; Mice, Transgenic ; Neural Stem Cells/cytology ; Olfactory Mucosa/cytology ; Olfactory Mucosa/growth & development ; Olfactory Receptor Neurons/cytology ; Staining and Labeling/methods ; Transcription Factor HES-1/metabolism
Czasopismo naukowe
Tytuł :
Cochlea cell-specific marker expression upon in vitro Hes1 knockdown.
Autorzy :
Batissoco AC; Otorrinolaringologia/LIM32, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.; Departamento de Otorrinolaringologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Lezirovitz K; Otorrinolaringologia/LIM32, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.; Departamento de Otorrinolaringologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Zanatta DB; Laboratório de Vetores Virais, Centro de Investigação Translacional em Oncologia/LIM24, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
Hemza CRML; Departamento de Otorrinolaringologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Vasques LR; Centro de Estudos sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brasil.
Strauss BE; Laboratório de Vetores Virais, Centro de Investigação Translacional em Oncologia/LIM24, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
Mingroni-Netto RC; Centro de Estudos sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brasil.
Haddad LA; Centro de Estudos sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brasil.
Bento RF; Otorrinolaringologia/LIM32, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.; Departamento de Otorrinolaringologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Oiticica J; Otorrinolaringologia/LIM32, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.; Departamento de Otorrinolaringologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
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Źródło :
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2021 May 17; Vol. 54 (7), pp. e10579. Date of Electronic Publication: 2021 May 17 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors*/genetics
Cochlea*
Animals ; Cell Differentiation ; Hair Cells, Auditory ; Mice ; Organ of Corti ; Receptors, Notch ; Transcription Factor HES-1/genetics
Czasopismo naukowe
Tytuł :
Antiandrogen abiraterone and docetaxel treatments affect Notch1, Jagged1 and Hes1 expressions in metastatic prostate cancer cells.
Autorzy :
Soylu H; Department of Histology and Embryology, Faculty of Medicine, Duzce University, 81620 Duzce, Turkey.
Kırca M; Department of Biochemistry, Faculty of Medicine, Kutahya Health Sciences University, 43100 Kutahya, Turkey.
Avcı S; Department of Histology and Embryology, Faculty of Medicine, Alanya Alaaddin Keykubat University, 07070 Antalya, Turkey.
Ozpolat B; Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Ustunel I; Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, TURKEY. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2021 Apr; Vol. 119, pp. 104607. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Androgen Antagonists/*pharmacology
Androstenes/*pharmacology
Docetaxel/*pharmacology
Jagged-1 Protein/*metabolism
Prostatic Neoplasms/*metabolism
Prostatic Neoplasms/*pathology
Receptor, Notch1/*metabolism
Transcription Factor HES-1/*metabolism
Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Male ; Neoplasm Metastasis ; Prostatic Neoplasms/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Autorzy :
Wang W; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Sun R; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zeng L; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chen Y; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zhang N; Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Cao S; Department of Nuclear Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Deng S; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Meng X; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: .
Yang S; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 01; Vol. 276, pp. 119439. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Cell Proliferation*
Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*pathology
Biomarkers, Tumor/*metabolism
Lung Neoplasms/*pathology
N-Acetylgalactosaminyltransferases/*metabolism
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Aged ; Apoptosis ; Biomarkers, Tumor/genetics ; Female ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; N-Acetylgalactosaminyltransferases/genetics ; Neoplasm Invasiveness ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Prognosis ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Survival Rate ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Whitefly HES1 binds to the intergenic region of Tomato yellow leaf curl China virus and promotes viral gene transcription.
Autorzy :
Wang YM; Ministry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
He YZ; Ministry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Ye XT; Ministry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
He WZ; Ministry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Liu SS; Ministry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Wang XW; Ministry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China. Electronic address: .
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Źródło :
Virology [Virology] 2020 Mar; Vol. 542, pp. 54-62. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Begomovirus/*genetics
Hemiptera/*metabolism
Hemiptera/*virology
Insect Proteins/*metabolism
Transcription Factor HES-1/*metabolism
Animals ; Begomovirus/pathogenicity ; Begomovirus/physiology ; DNA, Intergenic ; Gene Knockdown Techniques ; Genome, Viral ; Hemiptera/genetics ; Host Microbial Interactions/genetics ; Insect Proteins/antagonists & inhibitors ; Insect Proteins/genetics ; Insect Vectors/genetics ; Insect Vectors/metabolism ; Insect Vectors/virology ; Lycopersicon esculentum/virology ; Plant Diseases/virology ; Protein Binding ; Tobacco/virology ; Transcription Factor HES-1/antagonists & inhibitors ; Transcription Factor HES-1/genetics ; Transcription, Genetic ; Two-Hybrid System Techniques
SCR Organism :
Tomato yellow leaf curl China virus
Czasopismo naukowe
Tytuł :
Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance.
Autorzy :
Bosze B; Department of Cell Biology and Human Anatomy, University of California Davis, Davis, California 95616.
Moon MS; Department of Cell Biology and Human Anatomy, University of California Davis, Davis, California 95616.
Kageyama R; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507 Japan, and.; Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8501, Japan.
Brown NL; Department of Cell Biology and Human Anatomy, University of California Davis, Davis, California 95616, .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Feb 12; Vol. 40 (7), pp. 1501-1513. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye/*embryology
Neurogenesis/*physiology
Transcription Factor HES-1/*physiology
Animals ; Coloboma/genetics ; Coloboma/pathology ; Ependymoglial Cells/cytology ; Eye/growth & development ; Gastrulation ; Genetic Association Studies ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microphthalmos/genetics ; Microphthalmos/pathology ; Optic Disk/embryology ; Optic Disk/pathology ; Receptors, Notch/physiology ; Retina/abnormalities ; Retina/embryology ; Retinal Bipolar Cells/cytology ; Retinal Cone Photoreceptor Cells/metabolism ; Retinal Ganglion Cells/cytology ; Signal Transduction ; Transcription Factor HES-1/deficiency ; Transcription Factor HES-1/genetics
Czasopismo naukowe
Tytuł :
DNA-methylation-mediated silencing of miR-7-5p promotes gastric cancer stem cell invasion via increasing Smo and Hes1.
Autorzy :
Xin L; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Liu L; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Liu C; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhou LQ; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhou Q; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Yuan YW; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Li SH; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhang HT; Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2020 Mar; Vol. 235 (3), pp. 2643-2654. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation/*genetics
MicroRNAs/*genetics
Neoplastic Stem Cells/*pathology
Smoothened Receptor/*antagonists & inhibitors
Stomach Neoplasms/*pathology
Transcription Factor HES-1/*antagonists & inhibitors
Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Down-Regulation/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Hyaluronan Receptors/analysis ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Promoter Regions, Genetic/genetics ; Real-Time Polymerase Chain Reaction ; Signal Transduction/genetics ; Smoothened Receptor/genetics ; Transcription Factor HES-1/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease.
Autorzy :
Aquila G; Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Vieceli Dalla Sega F; Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.
Marracino L; Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
Pavasini R; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy.
Cardelli LS; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy.
Piredda A; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy.
Scoccia A; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy.
Martino V; Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Fortini F; Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.
Bononi I; Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
Martini F; Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
Manfrini M; Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.
Pannuti A; University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
Ferrari R; Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy.
Rizzo P; Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.; Department of Morphology, Surgery and Experimental Medicine and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
Campo G; Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 25; Vol. 21 (5). Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Blood Cells/*drug effects
Coronary Artery Disease/*metabolism
Platelet Aggregation Inhibitors/*pharmacology
Pulmonary Disease, Chronic Obstructive/*metabolism
Sirtuin 1/*genetics
Ticagrelor/*pharmacology
Transcription Factor HES-1/*genetics
Blood Cells/metabolism ; Cells, Cultured ; Epidermal Growth Factor/genetics ; Epidermal Growth Factor/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction ; Sirtuin 1/metabolism ; Transcription Factor HES-1/metabolism
Czasopismo naukowe
Tytuł :
Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells.
Autorzy :
Zhang Y; Developmental Biology/Signal Transduction, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. .
Lahmann I; Developmental Biology/Signal Transduction, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Baum K; Mathematical Modelling of Cellular Processes, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.; Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, Potsdam, Germany.
Shimojo H; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Mourikis P; Univ Paris Est Creteil, INSERM, IMRB, Creteil, France.
Wolf J; Mathematical Modelling of Cellular Processes, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.; Department of Mathematics and Computer Science, Free University Berlin, Berlin, Germany.
Kageyama R; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Birchmeier C; Developmental Biology/Signal Transduction, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. .; Neurowissenschaftliches Forschungzentrum, NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 26; Vol. 12 (1), pp. 1318. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Binding Proteins/*metabolism
Cell Differentiation/*physiology
Muscle Development/*physiology
Muscles/*metabolism
Stem Cells/*physiology
Animals ; Calcium-Binding Proteins/genetics ; Female ; Gene Expression Regulation, Developmental ; HEK293 Cells ; Humans ; Mice ; Mice, Knockout ; Muscle Development/genetics ; Mutation ; MyoD Protein/genetics ; MyoD Protein/metabolism ; Signal Transduction/physiology ; Transcription Factor HES-1/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
[miR-139 promotes homing of bone marrow mesenchymal stem cells (BMSCs) to lung tissues of asthmatic rats to inhibit inflammatory response of Th2 cells by down-regulating Notch1/Hes1 pathway].
Autorzy :
Wang K; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Zhu H; First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China. *Corresponding author, E-mail: .
Yang L; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Xu Q; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
Ren F; Graduate School, Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2021 Feb; Vol. 37 (2), pp. 97-104.
Typ publikacji :
Journal Article
MeSH Terms :
Asthma*/genetics
Mesenchymal Stem Cells*
MicroRNAs*/genetics
Animals ; Bone Marrow Cells ; Lung ; Rats ; Rats, Sprague-Dawley ; Receptor, Notch1/genetics ; Th2 Cells ; Transcription Factor HES-1/genetics
Czasopismo naukowe
Tytuł :
HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development.
Autorzy :
De Decker M; Department of Diagnostic Sciences, Ghent University, Ghent.
Lavaert M; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Roels J; Department of Diagnostic Sciences and of Bimolecular Medicine, Ghent University, Ghent, Belgium.
Tilleman L; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
Vandekerckhove B; Cancer Research Institute Ghent (CRIG),Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Leclercq G; Cancer Research Institute Ghent (CRIG),Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Van Nieuwerburgh F; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
Van Vlierberghe P; Cancer Research Institute Ghent (CRIG), Dept of Biomolecular Medicine, Ghent University, Belgium.
Taghon T; Cancer Research Institute Ghent (CRIG),Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium.
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Źródło :
Haematologica [Haematologica] 2021 Jan 01; Vol. 106 (1), pp. 130-141. Date of Electronic Publication: 2021 Jan 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors*/genetics
Hematopoietic Stem Cells*
Animals ; Cell Differentiation ; Hematopoiesis ; Homeodomain Proteins/genetics ; Humans ; Mice ; Receptor, Notch1/genetics ; T-Lymphocytes ; Transcription Factor HES-1/genetics
Czasopismo naukowe
Tytuł :
Uniform and Robust Nuclear Expression of HES1 in Neuroendocrine Neoplasms.
Autorzy :
Cui M; University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Case Western Reserve University, Cleveland, OH, USA.
Cai Z; University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Case Western Reserve University, Cleveland, OH, USA.
Awadallah A; University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Xin W; University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Case Western Reserve University, Cleveland, OH, USA.
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Źródło :
International journal of surgical pathology [Int J Surg Pathol] 2019 Dec; Vol. 27 (8), pp. 844-851. Date of Electronic Publication: 2019 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carcinoid Tumor/*pathology
Carcinoma, Neuroendocrine/*pathology
Transcription Factor HES-1/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Cell Nucleus/pathology ; Female ; Gastrointestinal Tract/cytology ; Gastrointestinal Tract/pathology ; Humans ; Immunohistochemistry ; Lung/cytology ; Lung/pathology ; Male ; Middle Aged ; Pancreas/cytology ; Pancreas/pathology ; Transcription Factor HES-1/analysis
Czasopismo naukowe
Tytuł :
Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina.
Autorzy :
Arai MA; Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan. .
Makita Y; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Yamaguchi Y; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Kawano H; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
Suganami A; Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Tamura Y; Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Ishibashi M; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 08; Vol. 10 (1), pp. 21433. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amoeba/*chemistry
Naphthoquinones/*chemical synthesis
Neural Stem Cells/*cytology
Transcription Factor HES-1/*chemistry
Transcription Factor HES-1/*metabolism
Animals ; Cell Differentiation/drug effects ; Cell Line ; Mice ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Naphthoquinones/chemistry ; Naphthoquinones/pharmacology ; Neural Stem Cells/drug effects ; Neural Stem Cells/metabolism ; Protein Conformation ; Protein Multimerization/drug effects
Czasopismo naukowe
Tytuł :
Single-cell lineage analysis reveals extensive multimodal transcriptional control during directed beta-cell differentiation.
Autorzy :
Weng C; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; The Biomedical Sciences Training Program (BSTP), School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Xi J; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Li H; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Cui J; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Gu A; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Medical Scientist Training Program (MSTP), School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lai S; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; The Biomedical Sciences Training Program (BSTP), School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Leskov K; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Ke L; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Master of Science in Biology Program, Department of Biology, College of Arts and Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jin F; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. .; Department of Population and Quantitative Health Sciences, Department of Electrical Engineering and Computer Science, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. .
Li Y; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. .
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Źródło :
Nature metabolism [Nat Metab] 2020 Dec; Vol. 2 (12), pp. 1443-1458. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*physiology
Cell Lineage/*physiology
Gene Expression Regulation, Developmental/*physiology
Insulin-Secreting Cells/*physiology
Cell Differentiation/genetics ; Cell Lineage/genetics ; Diabetes Mellitus/genetics ; Embryonic Stem Cells ; Gene Expression Regulation, Developmental/genetics ; Gene Knockdown Techniques ; Genes, Switch/genetics ; Glucose/pharmacology ; Humans ; Insulin Secretion/drug effects ; Transcription Factor 7-Like 2 Protein/genetics ; Transcription Factor HES-1/biosynthesis ; Transcription Factor HES-1/genetics
Czasopismo naukowe
Tytuł :
Circular RNA circCCDC9 alleviates ischaemic stroke ischaemia/reperfusion injury via the Notch pathway.
Autorzy :
Wu L; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Xu H; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Zhang W; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Chen Z; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
Li W; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Ke W; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Dec; Vol. 24 (24), pp. 14152-14159. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
RNA, Circular*
Ischemic Stroke/*etiology
Ischemic Stroke/*metabolism
Microtubule Proteins/*genetics
Receptors, Notch/*metabolism
Reperfusion Injury/*etiology
Reperfusion Injury/*metabolism
Animals ; Apoptosis/genetics ; Blood-Brain Barrier/metabolism ; Disease Models, Animal ; Gene Expression Regulation ; Gene Knockdown Techniques ; Ischemic Stroke/pathology ; Male ; Mice ; Reperfusion Injury/pathology ; Signal Transduction ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism
Czasopismo naukowe
Tytuł :
Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma.
Autorzy :
Matsumori T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kodama Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. .; Department of Gastroenterology, Kobe University Graduate School of Medicine, Hyogo, Japan.
Takai A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Shiokawa M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nishikawa Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Matsumoto T; Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon.
Takeda H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Marui S; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Okada H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hirano T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kuwada T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sogabe Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kakiuchi N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tomono T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Mima A; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Morita T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ueda T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tsuda M; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yamauchi Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kuriyama K; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sakuma Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ota Y; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Maruno T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Uza N; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Marusawa H; Department of Gastroenterology, Japanese Red Cross Hospital Osaka, Osaka, Japan.
Kageyama R; Institute for Frontier Life and Medical Sciences, Kyoto University, Shogoin-Kawahara, Sakyo-Ku, Kyoto, Japan.
Chiba T; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Kansai Electric Power Hospital, Osaka, Japan.
Seno H; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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Źródło :
Cancer research [Cancer Res] 2020 Dec 01; Vol. 80 (23), pp. 5305-5316. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bile Duct Neoplasms/*pathology
Bile Ducts, Intrahepatic/*pathology
Cholangiocarcinoma/*pathology
Transcription Factor HES-1/*genetics
Transcription Factor HES-1/*metabolism
Animals ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/metabolism ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/metabolism ; Diet/adverse effects ; Humans ; Mice, Knockout ; Mice, Transgenic ; Proto-Oncogene Proteins p21(ras)/genetics ; Receptors, Notch/metabolism
Czasopismo naukowe
Tytuł :
Crosstalk between Androgen-ZIP9 Signaling and Notch Pathway in Rodent Sertoli Cells.
Autorzy :
Kamińska A; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Marek S; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Pardyak L; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.; Center of Experimental and Innovative Medicine, University of Agriculture in Krakow, 30-248 Kraków, Poland.
Brzoskwinia M; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Bilinska B; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
Hejmej A; Department of Endocrinology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 05; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Androgens/*metabolism
Cation Transport Proteins/*physiology
Receptors, Notch/*metabolism
Sertoli Cells/*metabolism
Androgens/pharmacology ; Androgens/physiology ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cells, Cultured ; Male ; Mice ; Rats ; Receptor Cross-Talk/drug effects ; Receptor Cross-Talk/physiology ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Sertoli Cells/drug effects ; Sertoli Cells/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism
Czasopismo naukowe

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