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Tytuł:
HOXA9 Transcriptionally Promotes Apoptosis and Represses Autophagy by Targeting NF-κB in Cutaneous Squamous Cell Carcinoma.
Autorzy:
Han S; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangdong 510515, Guangzhou, China. .
Li X; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangdong 510515, Guangzhou, China. .
Liang X; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangdong 510515, Guangzhou, China. .
Zhou L; Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangdong 510515, Guangzhou, China. .
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Źródło:
Cells [Cells] 2019 Oct 31; Vol. 8 (11). Date of Electronic Publication: 2019 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Autophagy*
Homeodomain Proteins/*metabolism
Transcription Factor RelA/*metabolism
Animals ; Autophagy-Related Protein-1 Homolog/genetics ; Autophagy-Related Protein-1 Homolog/metabolism ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Homeodomain Proteins/antagonists & inhibitors ; Homeodomain Proteins/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Mice, Nude ; RNA Interference ; RNA, Small Interfering/metabolism ; RNA, Small Interfering/therapeutic use ; Signal Transduction ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Transcription Factor RelA/genetics ; Transplantation, Heterologous ; Up-Regulation ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Shengxian decoction decreases doxorubicin‑induced cardiac apoptosis by regulating the TREM1/NF‑κB signaling pathway.
Autorzy:
Yao L; Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China.
Gui M; Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China.
Li J; Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China.
Lu B; Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China.
Wang J; Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China.
Zhou X; Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China.
Fu D; Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Mar; Vol. 23 (3). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Apoptosis/*drug effects
Doxorubicin/*adverse effects
Drugs, Chinese Herbal/*pharmacology
Myocytes, Cardiac/*metabolism
Signal Transduction/*drug effects
Transcription Factor RelA/*metabolism
Triggering Receptor Expressed on Myeloid Cells-1/*metabolism
Animals ; Cell Line ; Doxorubicin/pharmacology ; Myocytes, Cardiac/pathology ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of long noncoding RNA MALAT1 suppresses high glucose-induced apoptosis and inflammation in human umbilical vein endothelial cells by suppressing the NF-κB signaling pathway.
Autorzy:
Gong YP; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.
Zhang YW; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.
Su XQ; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.
Gao HB; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.; Department of Endocrinology, Pingxiang People's Hospital, Pingxiang 337000, P.R. China.
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2020 Dec; Vol. 98 (6), pp. 669-675. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Glucose/*pharmacology
Human Umbilical Vein Endothelial Cells/*metabolism
RNA, Long Noncoding/*metabolism
Signal Transduction/*drug effects
Transcription Factor RelA/*metabolism
Humans ; Inflammation/chemically induced ; Inflammation/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage.
Autorzy:
Yu HC; Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62130, Taiwan.
Tung CH; Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62130, Taiwan.; School of Medicine, Tzu Chi University, Hualien City 97071, Taiwan.
Huang KY; Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62130, Taiwan.; School of Medicine, Tzu Chi University, Hualien City 97071, Taiwan.
Huang HB; Department of Life Science and Institute of Molecular Biology, National Chung Cheng University, Minxiong, Chiayi 62130, Taiwan.
Lu MC; Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62130, Taiwan.; School of Medicine, Tzu Chi University, Hualien City 97071, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 10; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 10.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*genetics
Bodily Secretions/*metabolism
Cell Adhesion/*genetics
Cytokines/*metabolism
Macrophages/*metabolism
Protein-Arginine Deiminase Type 2/*metabolism
Anti-Citrullinated Protein Antibodies/blood ; Apoptosis/drug effects ; Arthritis, Rheumatoid/blood ; CRISPR-Cas Systems ; Cytokines/genetics ; Gene Knockout Techniques ; Humans ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Protein-Arginine Deiminase Type 2/genetics ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcription Factor RelA/metabolism ; U937 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
NF-κB inhibitor with Temozolomide results in significant apoptosis in glioblastoma via the NF-κB(p65) and actin cytoskeleton regulatory pathways.
Autorzy:
Avci NG; Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Houston, TX, 77204-5060, USA.
Ebrahimzadeh-Pustchi S; Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Houston, TX, 77204-5060, USA.
Akay YM; Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Houston, TX, 77204-5060, USA.
Esquenazi Y; UTHealth Neurosurgery, McGovern Medical School, Memorial Hermann at Texas Medical Center, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Tandon N; UTHealth Neurosurgery, McGovern Medical School, Memorial Hermann at Texas Medical Center, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Zhu JJ; UTHealth Neurosurgery, McGovern Medical School, Memorial Hermann at Texas Medical Center, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Akay M; Department of Biomedical Engineering, University of Houston, 3517 Cullen Blvd, Houston, TX, 77204-5060, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Aug 07; Vol. 10 (1), pp. 13352. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Actin Cytoskeleton/*metabolism
Apoptosis/*drug effects
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
NF-kappa B/*metabolism
Signal Transduction/*drug effects
Temozolomide/*therapeutic use
Transcription Factor RelA/*metabolism
Actin Cytoskeleton/drug effects ; Cell Line, Tumor ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoblotting ; NF-kappa B/antagonists & inhibitors ; Nitriles/pharmacology ; Sulfones/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein kinase C-α (PKCα) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder.
Autorzy:
Zheng J; Department of Urology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China. .
Kong C; Department of Urology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
Yang X; Department of Cardiovascular, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
Cui X; Department of Urology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
Lin X; Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, 110001, China.
Zhang Z; Department of Urology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China.
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Źródło:
BMC cancer [BMC Cancer] 2017 Jun 19; Vol. 17 (1), pp. 432. Date of Electronic Publication: 2017 Jun 19.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Carcinoma, Transitional Cell/*metabolism
Carcinoma, Transitional Cell/*pathology
Protein Kinase C-alpha/*metabolism
Transcription Factor RelA/*metabolism
Urinary Bladder Neoplasms/*metabolism
Urinary Bladder Neoplasms/*pathology
Active Transport, Cell Nucleus ; Adult ; Aged ; Biomarkers ; Carcinoma, Transitional Cell/genetics ; Cell Line, Tumor ; Female ; Gene Expression ; Gene Expression Profiling ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Protein Binding ; Protein Kinase C-alpha/genetics ; Protein Transport ; Signal Transduction ; Transcription Factor RelA/genetics ; Urinary Bladder Neoplasms/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Amelioration of Enterotoxigenic Escherichia coli -Induced Intestinal Barrier Disruption by Low-Molecular-Weight Chitosan in Weaned Pigs is Related to Suppressed Intestinal Inflammation and Apoptosis.
Autorzy:
Wan J; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Zhang J; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Wu G; Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Chen D; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Yu B; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Huang Z; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Luo Y; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Zheng P; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Luo J; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Mao X; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Yu J; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
He J; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 16; Vol. 20 (14). Date of Electronic Publication: 2019 Jul 16.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Anti-Inflammatory Agents/*therapeutic use
Chitosan/*therapeutic use
Escherichia coli Infections/*drug therapy
Intestinal Mucosa/*drug effects
Animals ; Anti-Inflammatory Agents/pharmacology ; Chitosan/pharmacology ; Enterotoxigenic Escherichia coli ; Interleukin-6/genetics ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Occludin/genetics ; Occludin/metabolism ; Swine ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid.
Autorzy:
Sim DY; College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea. .
Lee HJ; College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea. .
Jung JH; College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea. .
Im E; College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea. .
Hwang J; College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea. .
Kim DS; College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea. .
Kim SH; College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jun 19; Vol. 20 (12). Date of Electronic Publication: 2019 Jun 19.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Apoptosis/*genetics
Carboxylic Acids/*pharmacology
MicroRNAs/*genetics
Naphthalenes/*pharmacology
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
Transcription Factor RelA/*metabolism
Acetylation ; Biomarkers ; Carboxylic Acids/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Fluorescent Antibody Technique ; Gene Expression Regulation/drug effects ; Humans ; Interleukin-6/metabolism ; Naphthalenes/chemistry ; Phosphorylation ; Poly(ADP-ribose) Polymerases/metabolism ; Proteolysis ; RNA Interference
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells.
Autorzy:
Srinivasan M; School of Dentistry, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Bayon B; Institute of Psychiatry Research, Department of Psychiatry and Medical & Molecular Genetics, School of Medicine, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Chopra N; Institute of Psychiatry Research, Department of Psychiatry and Medical & Molecular Genetics, School of Medicine, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
Lahiri DK; Institute of Psychiatry Research, Department of Psychiatry and Medical & Molecular Genetics, School of Medicine, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
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Źródło:
PloS one [PLoS One] 2016 Oct 20; Vol. 11 (10), pp. e0160314. Date of Electronic Publication: 2016 Oct 20 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides/*toxicity
Apoptosis/*drug effects
Neurons/*metabolism
Peptides/*pharmacology
Transcription Factor RelA/*metabolism
Binding Sites ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cells, Cultured ; Fetus/cytology ; Humans ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Molecular Docking Simulation ; Neurons/cytology ; Neurons/drug effects ; Peptides/chemistry ; Peptides/genetics ; Peptides/metabolism ; Protein Binding ; Protein Structure, Tertiary ; RNA, Messenger/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/pharmacology ; Transcription Factor RelA/antagonists & inhibitors ; Transcription Factor RelA/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibitory Effects of Antimicrobial Peptide JH-3 on Salmonella enterica Serovar Typhimurium Strain CVCC541 Infection-Induced Inflammatory Cytokine Release and Apoptosis in RAW264.7 Cells.
Autorzy:
Wang L; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. wlei_.; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China. wlei_.
Zhao X; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. .; Faculty of Veterinary Medicine, Sumy National Agrarian University, Sumy 40021, Ukraine. .
Xia X; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. xiaojingxia_.
Zhu C; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. chunlingzhu_.
Zhang H; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. huihuizhang_.
Qin W; Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, 1000, The Netherlands. .
Xu Y; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. yanzhaoxu_.
Hang B; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. bolinhang_.
Sun Y; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. yaweisun_
Chen S; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. shijunchen_.
Jiang J; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. jinqingjiang_.
Zhang G; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China. .
Hu J; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Feb 07; Vol. 24 (3). Date of Electronic Publication: 2019 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Infective Agents/*pharmacology
Apoptosis/*drug effects
Cytokines/*metabolism
Inflammation Mediators/*metabolism
Peptides/*pharmacology
Salmonella typhimurium/*drug effects
Animals ; Anti-Infective Agents/chemistry ; Biomarkers ; Cytokines/genetics ; Gene Expression ; Gene Expression Regulation/drug effects ; Macrophages/drug effects ; Macrophages/metabolism ; Macrophages/microbiology ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Peptides/chemistry ; RAW 264.7 Cells ; Salmonella Infections/genetics ; Salmonella Infections/metabolism ; Salmonella Infections/microbiology ; Signal Transduction/drug effects ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Acetazolamide protects rat articular chondrocytes from IL-1β-induced apoptosis by inhibiting the activation of NF-κB signal pathway.
Autorzy:
Cai L; a Department of Pathology, School of Basic Medicine, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China.
Chen WN; b School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China.
Li R; b School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China.; c School of Pharmacy, Macau University of Science and Technology, Avenida Wai Long Road, Macau, China.
Liu MM; b School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China.
Lei C; b School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China.
Li CM; b School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, China.
Qiu YY; c School of Pharmacy, Macau University of Science and Technology, Avenida Wai Long Road, Macau, China.
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Źródło:
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2018 Nov; Vol. 96 (11), pp. 1104-1111. Date of Electronic Publication: 2018 Aug 01.
Typ publikacji:
Journal Article
MeSH Terms:
Acetazolamide/*pharmacology
Apoptosis/*drug effects
Carbonic Anhydrase Inhibitors/*pharmacology
Chondrocytes/*drug effects
Signal Transduction/*drug effects
Animals ; Cartilage, Articular/cytology ; Cells, Cultured ; Chondrocytes/metabolism ; Interleukin-1beta/metabolism ; Primary Cell Culture ; Rats ; Rats, Sprague-Dawley ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Antioxidant, anti-inflammatory, and anti-apoptotic effects of zinc supplementation in testes of rats with experimentally induced diabetes.
Autorzy:
Aziz NM; a Department of Physiology, Faculty of Medicine, Minia University, Delegated to Deraya University - New Minia City, Eygpt.
Kamel MY; b Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt.
Mohamed MS; c Department of Internal Medicine, Deraya University, Minia, Egypt.
Ahmed SM; d Department of Anatomy, Faculty of Medicine, Minia University, Minia, Egypt.
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Źródło:
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2018 Oct; Vol. 43 (10), pp. 1010-1018. Date of Electronic Publication: 2018 May 04.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Dietary Supplements*
Apoptosis/*drug effects
Diabetes Mellitus, Experimental/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*pharmacology
Inflammation Mediators/*metabolism
Metformin/*pharmacology
Oxidative Stress/*drug effects
Testis/*drug effects
Zinc/*pharmacology
Animals ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/pathology ; Follicle Stimulating Hormone/blood ; Insulin/blood ; Male ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Testis/metabolism ; Testis/pathology ; Testosterone/blood ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gastrodin inhibits high glucose‑induced human retinal endothelial cell apoptosis by regulating the SIRT1/TLR4/NF‑κBp65 signaling pathway.
Autorzy:
Zhang TH; Department of Ophthalmology, The Second People's Hospital of Jinan, Jinan, Shandong 250001, P.R. China.
Huang CM; Department of Ophthalmology, The Second People's Hospital of Jinan, Jinan, Shandong 250001, P.R. China.
Gao X; Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong 250031, P.R. China.
Wang JW; Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong 250031, P.R. China.
Hao LL; Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong 250031, P.R. China.
Ji Q; Department of Ophthalmology, The Second People's Hospital of Jinan, Jinan, Shandong 250001, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2018 Jun; Vol. 17 (6), pp. 7774-7780. Date of Electronic Publication: 2018 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Benzyl Alcohols/*pharmacology
Endothelial Cells/*drug effects
Endothelial Cells/*metabolism
Glucosides/*pharmacology
Sirtuin 1/*metabolism
Toll-Like Receptor 4/*metabolism
Transcription Factor RelA/*metabolism
Cell Survival/drug effects ; Glucose/metabolism ; Humans ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Retina/cytology ; Retina/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Marinobufagenin inhibits glioma growth through sodium pump α1 subunit and ERK signaling-mediated mitochondrial apoptotic pathway.
Autorzy:
Lan YL; Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.; Department of Pharmacy, Dalian Medical University, Dalian, 116044, China.; Department of Physiology, Dalian Medical University, Dalian, 116044, China.
Wang X; Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
Lou JC; Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
Xing JS; Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
Zou S; Department of Physiology, Dalian Medical University, Dalian, 116044, China.
Yu ZL; Department of Pharmacy, Dalian Medical University, Dalian, 116044, China.
Ma XC; Department of Pharmacy, Dalian Medical University, Dalian, 116044, China.
Wang H; Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
Zhang B; Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
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Źródło:
Cancer medicine [Cancer Med] 2018 May; Vol. 7 (5), pp. 2034-2047. Date of Electronic Publication: 2018 Mar 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bufanolides/*pharmacology
Extracellular Signal-Regulated MAP Kinases/*metabolism
Membrane Potential, Mitochondrial/*drug effects
Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors
Animals ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cytochromes c/metabolism ; Glioma/drug therapy ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitochondria/physiology ; RNA Interference ; RNA, Small Interfering/genetics ; Signal Transduction/drug effects ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism ; Transcription Factor RelA/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fibrinogen links podocyte injury with Toll-like receptor 4 and is associated with disease activity in FSGS patients.
Autorzy:
Wang H; Division of Nephrology, Jinling Hospital, Southern Medical University, Nanjing, China.; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Zheng C; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Xu X; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Zhao Y; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Lu Y; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Liu Z; Division of Nephrology, Jinling Hospital, Southern Medical University, Nanjing, China.; National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
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Źródło:
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2018 May; Vol. 23 (5), pp. 418-429.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Fibrinogen/*metabolism
Glomerulosclerosis, Focal Segmental/*metabolism
Podocytes/*metabolism
Toll-Like Receptor 4/*metabolism
Actin Cytoskeleton/metabolism ; Actin Cytoskeleton/pathology ; Adolescent ; Adult ; Albuminuria/chemically induced ; Albuminuria/metabolism ; Albuminuria/pathology ; Animals ; Cell Line ; Disease Models, Animal ; Doxorubicin ; Female ; Fibrinogen/urine ; Glomerulosclerosis, Focal Segmental/chemically induced ; Glomerulosclerosis, Focal Segmental/drug therapy ; Glomerulosclerosis, Focal Segmental/pathology ; Glucocorticoids/therapeutic use ; Humans ; Male ; Mice, Inbred BALB C ; Phosphorylation ; Podocytes/pathology ; Prednisone/therapeutic use ; RNA Interference ; Remission Induction ; Signal Transduction ; Toll-Like Receptor 4/genetics ; Transcription Factor RelA/metabolism ; Transfection ; Treatment Outcome ; Young Adult ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A New Ligustrazine Derivative-Selective Cytotoxicity by Suppression of NF-κB/p65 and COX-2 Expression on Human Hepatoma Cells. Part 3.
Autorzy:
Zhang C; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
Yan W; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
Li B; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
Xu B; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
Gong Y; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
Chu F; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
Zhang Y; Department of Pathology, Beijing University of Chinese Medicine, Beijing 100102, China. .
Yao Q; School of Nursing, Beijing University of Chinese Medicine, Beijing 100102, China. .
Wang P; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
Lei H; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2015 Jul 17; Vol. 16 (7), pp. 16401-13. Date of Electronic Publication: 2015 Jul 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*metabolism
Cyclooxygenase 2/*metabolism
Pyrazines/*pharmacology
Transcription Factor RelA/*metabolism
Animals ; Cyclooxygenase 2/genetics ; Dogs ; HT29 Cells ; HeLa Cells ; Humans ; Madin Darby Canine Kidney Cells ; Transcription Factor RelA/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
PAR1‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells.
Autorzy:
Zhang S; Department of Graduate School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Liu Y; Department of Intensive Care Unit, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Wang Z; Department of Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China.
Liu J; Department of Graduate School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Gu Z; Department of Intensive Care Unit, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, P.R. China.
Xu Q; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of People's Liberation Army, Guangzhou, Guangdong 510010, P.R. China.
Su L; Department of Graduate School, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 May; Vol. 15 (5), pp. 2595-2603. Date of Electronic Publication: 2017 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*physiology
Heat-Shock Response/*physiology
Proto-Oncogene Proteins c-jun/*metabolism
Receptor, PAR-1/*metabolism
Signal Transduction/*physiology
Apoptosis/drug effects ; Caspase 3/genetics ; Caspase 3/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-jun/genetics ; Pyrroles/pharmacology ; Quinazolines/pharmacology ; Receptor, PAR-1/antagonists & inhibitors ; Receptor, PAR-1/genetics ; Signal Transduction/drug effects ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibition of BRD4 attenuates cardiomyocyte apoptosis via NF-κB pathway in a rat model of myocardial infarction.
Autorzy:
Sun Y; Department of Cardiac Surgery, the Affiliated Zhongshan Hospital of Fudan University, Xuhui, Shanghai, China.
Xie Y; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Du L; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
Sun J; Department of Cardiology, the Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China.
Liu Z; Department of Physiology and Pathophysiology, School of Basic Medical Science, Tianjin Medical University, Heping, Tianjin, China.
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Źródło:
Cardiovascular therapeutics [Cardiovasc Ther] 2018 Apr; Vol. 36 (2). Date of Electronic Publication: 2018 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
RNA Interference*
RNAi Therapeutics*
Myocardial Infarction/*prevention & control
Myocytes, Cardiac/*metabolism
NF-kappa B/*metabolism
Nuclear Proteins/*antagonists & inhibitors
Transcription Factors/*antagonists & inhibitors
Acetylation ; Animals ; Animals, Newborn ; Atrial Natriuretic Factor/genetics ; Atrial Natriuretic Factor/metabolism ; Cell Hypoxia ; Cells, Cultured ; Cellular Microenvironment ; Disease Models, Animal ; Female ; Myocardial Infarction/genetics ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocytes, Cardiac/pathology ; Natriuretic Peptide, Brain/genetics ; Natriuretic Peptide, Brain/metabolism ; Promoter Regions, Genetic ; Rats, Sprague-Dawley ; Signal Transduction ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Aloin Suppresses Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Inhibiting the Activation of NF-κB.
Autorzy:
Luo X; Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. .
Zhang H; Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. .
Wei X; Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. .
Shi M; Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. .
Fan P; Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. .
Xie W; Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. .; Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. .
Zhang Y; Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. .; Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. .
Xu N; Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. .; Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2018 Feb 26; Vol. 23 (3). Date of Electronic Publication: 2018 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents/*chemistry
Apoptosis/*drug effects
Emodin/*analogs & derivatives
Inflammation/*etiology
Inflammation/*metabolism
NF-kappa B/*antagonists & inhibitors
Animals ; Cell Survival/drug effects ; Cyclooxygenase 2/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Emodin/pharmacology ; Inflammation/drug therapy ; Inflammation Mediators/metabolism ; Lipopolysaccharides/adverse effects ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Models, Biological ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type II/metabolism ; Phosphorylation ; Protein Transport ; Signal Transduction/drug effects ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 109

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