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Tytuł :
Sensing an Oxygen Sensor: Development and Application of Activity-Based Assays Directly Monitoring HIF Heterodimerization.
Autorzy :
Janssens LK; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
Stove CP; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Nov 02; Vol. 93 (43), pp. 14462-14470. Date of Electronic Publication: 2021 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Procollagen-Proline Dioxygenase*
Transcription Factors*
Basic Helix-Loop-Helix Transcription Factors ; Biological Assay ; HEK293 Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Oxygen
Czasopismo naukowe
Tytuł :
HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways.
Autorzy :
Miyamoto R; Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.
Kanai A; Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Okuda H; Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.
Komata Y; Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.
Takahashi S; Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.; Department of Hematology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Matsui H; Department of Molecular Laboratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Inaba T; Department of Molecular Oncology and Leukemia Program Project, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Yokoyama A; Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.; Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan.
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Źródło :
ELife [Elife] 2021 Jul 26; Vol. 10. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Factors*
Cell Transformation, Neoplastic/*metabolism
Homeodomain Proteins/*metabolism
Neoplasm Proteins/*metabolism
Animals ; Carcinogenesis/genetics ; Female ; Gene Expression Regulation, Leukemic ; HEK293 Cells ; Homeodomain Proteins/genetics ; Humans ; Leukemia, Myeloid/metabolism ; Mice ; Mice, Inbred C57BL ; Myeloid-Lymphoid Leukemia Protein/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; SOXC Transcription Factors/genetics ; SOXC Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs.
Autorzy :
Kuretani A; Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Yamamoto T; Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Taira M; Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.; Department of Biological Sciences, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan.
Michiue T; Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. .; Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan. .
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Źródło :
BMC ecology and evolution [BMC Ecol Evol] 2021 Jul 29; Vol. 21 (1), pp. 147. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Factors*/genetics
Zebrafish*/genetics
Animals ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Humans ; Mice ; Phylogeny ; Repressor Proteins/genetics ; Synteny
Czasopismo naukowe
Tytuł :
Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression.
Autorzy :
Cleary CM; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.
James S; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.
Maher BJ; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Mulkey DK; Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 13; Vol. 12 (1), pp. 5962. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Haploinsufficiency*
Homeodomain Proteins/*genetics
Hyperventilation/*genetics
Intellectual Disability/*genetics
NAV1.8 Voltage-Gated Sodium Channel/*genetics
Neurons/*metabolism
Transcription Factor 4/*genetics
Transcription Factors/*genetics
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Benzimidazoles/pharmacology ; Brain Stem/drug effects ; Brain Stem/metabolism ; Brain Stem/pathology ; Carbon Dioxide/metabolism ; Carbon Dioxide/pharmacology ; Disease Models, Animal ; Facies ; Gene Expression Regulation ; Homeodomain Proteins/metabolism ; Humans ; Hyperventilation/drug therapy ; Hyperventilation/metabolism ; Hyperventilation/pathology ; Intellectual Disability/drug therapy ; Intellectual Disability/metabolism ; Intellectual Disability/pathology ; Male ; Mice ; Mice, Knockout ; NAV1.8 Voltage-Gated Sodium Channel/metabolism ; Neurons/drug effects ; Neurons/pathology ; Psychomotor Performance/drug effects ; Psychomotor Performance/physiology ; Pyrazoles/pharmacology ; Respiration/drug effects ; Transcription Factor 4/deficiency ; Transcription Factors/metabolism
SCR Disease Name :
Pitt-Hopkins syndrome
Czasopismo naukowe
Tytuł :
Saussurea involucrata (Snow Lotus) ICE1 and ICE2 Orthologues Involved in Regulating Cold Stress Tolerance in Transgenic Arabidopsis .
Autorzy :
Wu CL; Department of Life Sciences, Tzu Chi University, Hualien 97004, Taiwan.
Lin LF; Department of Life Sciences, Tzu Chi University, Hualien 97004, Taiwan.
Hsu HC; The Society of Wilderness, Taipei 10073, Taiwan.
Huang LF; Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Zhongli, Taoyuan 32003, Taiwan.
Hsiao CD; Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 320314, Taiwan.
Chou ML; Department of Life Sciences, Tzu Chi University, Hualien 97004, Taiwan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 07; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cold-Shock Response*
Gene Expression Regulation, Plant*
Arabidopsis/*physiology
Plant Proteins/*metabolism
Plants, Genetically Modified/*physiology
Saussurea/*physiology
Transcription Factors/*metabolism
Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Plant Proteins/genetics ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Saussurea/genetics ; Saussurea/metabolism ; Transcription Factors/genetics ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer.
Autorzy :
Cejas P; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. .; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. .; Translational Oncology Laboratory, Hospital La Paz Institute for Health Research (IdiPAZ) and CIBERONC, La Paz University Hospital, Madrid, Spain. .
Xie Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Font-Tello A; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Lim K; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Syamala S; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Qiu X; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Tewari AK; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shah N; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Nguyen HM; Department of Urology, University of Washington, Seattle, WA, USA.
Patel RA; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Brown L; Department of Urology, University of Washington, Seattle, WA, USA.
Coleman I; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hackeng WM; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Brosens L; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Dreijerink KMA; Department of Endocrinology, Amsterdam UMC, Amsterdam, The Netherlands.
Ellis L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Alaiwi SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Baca S; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Beltran H; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Khani F; Weill Cornell Medical Center, Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, New York, NY, USA.
Pomerantz M; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Dall'Agnese A; Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA, 02142, USA.
Crowdis J; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bellmunt J; Beth Israel Deaconess Medical Center and PSMAR-IMIM Lab. Harvard Medical School, Boston, Massachusetts, USA.
Morrisey C; Department of Urology, University of Washington, Seattle, WA, USA.
Nelson PS; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
DeCaprio J; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Farago A; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Dyson N; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Drapkin B; Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, Dallas, TX, USA.; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Liu XS; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Freedman M; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Haffner MC; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Pathology, University of Washington, Seattle, WA, USA.
Corey E; Department of Urology, University of Washington, Seattle, WA, USA.
Brown M; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. .; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. .
Long HW; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. .; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 01; Vol. 12 (1), pp. 5775. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Carcinoma, Neuroendocrine/*genetics
Prostatic Neoplasms/*genetics
Transcription Factors/*metabolism
Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/physiology ; Humans ; Male ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
ELF1 Transcription Factor Enhances the Progression of Glioma via ATF5 promoter.
Autorzy :
Hu M; Department of Special Medicine, Basic Medicine College, Qingdao University, Qingdao, Shandong 266071, P. R. China.
Li H; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China.
Xie H; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China.
Fan M; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China.
Wang J; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China.
Zhang N; Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China.
Ma J; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China.
Che S; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P. R. China.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Apr 07; Vol. 12 (7), pp. 1252-1261. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Activating Transcription Factors*/genetics
Activating Transcription Factors*/metabolism
Glioma*/genetics
Cell Line, Tumor ; Cyclic AMP Response Element-Binding Protein ; Humans ; Nuclear Proteins ; Promoter Regions, Genetic ; Transcription Factors/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
[Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3, с-Мус and FoxG1 Genes in the Developing Mouse Brain].
Autorzy :
Illarionova NB; Institute of Cytology and Genetics Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.; .
Borisova MA; Institute of Cytology and Genetics Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Bazhenova EY; Institute of Cytology and Genetics Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Zabelina DS; Novosibirsk State University, Novosibirsk, 630090 Russia.
Fursenko DV; Institute of Gene Biology Russian Academy of Sciences, Moscow, 119334 Russia.
Kulikov AV; Institute of Cytology and Genetics Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
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Źródło :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2021 May-Jun; Vol. 55 (3), pp. 422-430.
Typ publikacji :
Journal Article
MeSH Terms :
Brain*
Transcription Factors*/genetics
Animals ; Fibroblast Growth Factor 9 ; Forkhead Transcription Factors/genetics ; Gene Knockout Techniques ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Tissue Proteins ; Proto-Oncogene Proteins c-myc
Czasopismo naukowe
Tytuł :
The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function.
Autorzy :
Hayashi S; Laboratory of Embryology, Institute of Medical Advanced Sciences, Tokushima University, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan.
Suzuki H; Laboratory of Embryology, Institute of Medical Advanced Sciences, Tokushima University, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan.
Takemoto T; Laboratory of Embryology, Institute of Medical Advanced Sciences, Tokushima University, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan. Electronic address: .
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Źródło :
Developmental biology [Dev Biol] 2021 Oct; Vol. 478, pp. 155-162. Date of Electronic Publication: 2021 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrulation*
Kidney/*embryology
Mesoderm/*embryology
Stem Cells/*physiology
T-Box Domain Proteins/*metabolism
Transcription Factors/*metabolism
Animals ; Bone Morphogenetic Proteins/metabolism ; Cell Lineage ; Forkhead Transcription Factors/metabolism ; Mesenchymal Stem Cells/physiology ; Mesoderm/cytology ; Mice ; Neural Stem Cells/physiology ; Organogenesis ; Signal Transduction ; Somites/cytology ; Somites/physiology
Czasopismo naukowe
Tytuł :
scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse.
Autorzy :
Wittmann MT; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Katada S; Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Sock E; Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Kirchner P; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Ekici AB; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Wegner M; Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Nakashima K; Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Lie DC; Institute of Biochemistry, Emil Fischer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Reis A; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
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Źródło :
Development (Cambridge, England) [Development] 2021 Jul 15; Vol. 148 (14). Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
RNA, Small Cytoplasmic/*metabolism
Transcription Factor 4/*genetics
Transcription Factor 4/*metabolism
Transcription Factors/*genetics
Transcription Factors/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Differentiation ; DNA Helicases ; Embryo, Mammalian ; Forkhead Transcription Factors ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Intellectual Disability ; Matrix Attachment Region Binding Proteins ; Mice ; Mice, Knockout ; Nerve Tissue Proteins ; Neurons/physiology ; Nuclear Proteins ; Protein Interaction Domains and Motifs ; RNA, Small Cytoplasmic/genetics ; SOXC Transcription Factors ; Schizophrenia/genetics ; Schizophrenia/metabolism
Czasopismo naukowe
Tytuł :
HAND transcription factors cooperatively specify the aorta and pulmonary trunk.
Autorzy :
Vincentz JW; Herman B Wells Center for Pediatric Research Department of Pediatrics, Anatomy, Biochemistry, and Medical and Molecular Genetics, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, 46202-5225, USA. Electronic address: .
Firulli BA; Herman B Wells Center for Pediatric Research Department of Pediatrics, Anatomy, Biochemistry, and Medical and Molecular Genetics, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, 46202-5225, USA.
Toolan KP; Herman B Wells Center for Pediatric Research Department of Pediatrics, Anatomy, Biochemistry, and Medical and Molecular Genetics, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, 46202-5225, USA.
Osterwalder M; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA; Department for BioMedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008, Bern, Switzerland.
Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA; U.S. Department of Energy Joint Genome Institute, Berkeley, CA, 94720, USA; Comparative Biochemistry Program, University of California, Berkeley, CA, 94720, USA.
Firulli AB; Herman B Wells Center for Pediatric Research Department of Pediatrics, Anatomy, Biochemistry, and Medical and Molecular Genetics, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, 46202-5225, USA. Electronic address: .
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Źródło :
Developmental biology [Dev Biol] 2021 Aug; Vol. 476, pp. 1-10. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*genetics
Heart/*embryology
Heart Defects, Congenital/*genetics
Animals ; Aorta/embryology ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cardiac Output/physiology ; Cell Movement/genetics ; Gene Expression Regulation, Developmental/genetics ; Heart Defects, Congenital/metabolism ; Homeodomain Proteins/metabolism ; Mice ; Mice, Knockout ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Neural Crest/metabolism ; Phenotype ; Signal Transduction/genetics ; Transcription Factors/genetics
SCR Disease Name :
Conotruncal cardiac defects
Czasopismo naukowe
Tytuł :
Basic Helix-Loop-Helix (bHLH) Transcription Factors Regulate a Wide Range of Functions in Arabidopsis.
Autorzy :
Hao Y; Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Zong X; Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Ren P; Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Qian Y; Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Fu A; Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 01; Vol. 22 (13). Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arabidopsis/*genetics
Basic Helix-Loop-Helix Transcription Factors/*genetics
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Amino Acid Sequence ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Gene Expression ; Genome, Plant ; Helix-Loop-Helix Motifs ; Multigene Family ; Phylogeny ; Plant Proteins/genetics ; Sequence Analysis, DNA/methods ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Reactive oxygen species coordinate the transcriptional responses to iron availability in Arabidopsis.
Autorzy :
von der Mark C; Institute of Botany, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany.; Group of Plant Vascular Development, Swiss Federal Institute of Technology (ETH) Zurich, CH-8092 Zurich, Switzerland.
Ivanov R; Institute of Botany, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany.
Eutebach M; Institute of Botany, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany.
Maurino VG; Department of Molecular Plant Physiology, Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Kirschalle 1, D-53115 Bonn, Germany.
Bauer P; Institute of Botany, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany.; Cluster of Excellence on Plant Science (CEPLAS), Heinrich Heine University, D-40225 Düsseldorf, Germany.
Brumbarova T; Institute of Botany, Heinrich Heine University, Universitätsstr. 1, D-40225 Düsseldorf, Germany.
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Źródło :
Journal of experimental botany [J Exp Bot] 2021 Mar 17; Vol. 72 (6), pp. 2181-2195.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arabidopsis*/genetics
Arabidopsis*/metabolism
Arabidopsis Proteins*
Basic Helix-Loop-Helix Transcription Factors*/genetics
Basic Helix-Loop-Helix Transcription Factors*/metabolism
Iron/*metabolism
Reactive Oxygen Species/*metabolism
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Gene Expression Regulation, Plant ; Hydrogen Peroxide ; Plant Roots/metabolism
Czasopismo naukowe
Tytuł :
Sis1 delivers the State of the Union.
Autorzy :
Khan D; Department of Biochemistry, Stanford University, Stanford, CA.
Brandman O; Department of Biochemistry, Stanford University, Stanford, CA.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Jan 04; Vol. 220 (1).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
Heat-Shock Response*
Transcription Factors*/metabolism
Gene Expression Regulation ; Heat Shock Transcription Factors/genetics ; Heat Shock Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.
Autorzy :
Bellchambers HM; Early Mammalian Development Laboratory, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.
Barratt KS; Early Mammalian Development Laboratory, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.
Diamand KEM; Early Mammalian Development Laboratory, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.
Arkell RM; Early Mammalian Development Laboratory, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 28; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Sumoylation*
Transcription, Genetic*
Wnt Signaling Pathway*
Embryo, Mammalian/*embryology
Neural Crest/*metabolism
Transcription Factors/*metabolism
Animals ; Embryo, Mammalian/cytology ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Mice ; Mice, Transgenic ; Neural Crest/cytology ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
EIN3-Mediated Ethylene Signaling Attenuates Auxin Response during Hypocotyl Thermomorphogenesis.
Autorzy :
Kim JY; Department of Chemistry, Seoul National University, Seoul 08826, Korea.
Park YJ; Department of Chemistry, Seoul National University, Seoul 08826, Korea.
Lee JH; Department of Chemistry, Seoul National University, Seoul 08826, Korea.
Kim ZH; Department of Chemistry, Seoul National University, Seoul 08826, Korea.
Park CM; Department of Chemistry, Seoul National University, Seoul 08826, Korea.; Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea.
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Źródło :
Plant & cell physiology [Plant Cell Physiol] 2021 Sep 24; Vol. 62 (4), pp. 708-720.
Typ publikacji :
Journal Article
MeSH Terms :
Arabidopsis/*physiology
Arabidopsis Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Ethylenes/*metabolism
Hypocotyl/*physiology
Transcription Factors/*metabolism
Arabidopsis Proteins/genetics ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Plant ; Hypocotyl/growth & development ; Indoleacetic Acids/metabolism ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/metabolism ; Plants, Genetically Modified ; Signal Transduction ; Temperature ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Discovery of Klf2 interactors in mouse embryonic stem cells by immunoprecipitation-mass spectrometry utilizing exogenously expressed bait.
Autorzy :
Seo L; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
Kim YI; Center for Bioanalysis, Korea Research Institute of Standards and Science, Daejeon 34113, South Korea.
Kim H; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
Hyun K; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
Kim J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea. Electronic address: .
Lee JE; Division of Policy and Strategy, Korea Research Institute of Standards and Science, Daejeon 34113, South Korea. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2021 Sep; Vol. 1869 (9), pp. 140672. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunoprecipitation/*methods
Kruppel-Like Transcription Factors/*metabolism
Mass Spectrometry/*methods
Animals ; Cell Line ; DNA-Binding Proteins ; Gene Expression/genetics ; Gene Expression Regulation, Developmental/genetics ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/physiology ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Protein Binding ; Transcription Factors
Czasopismo naukowe
Tytuł :
Single-minded 2 is required for left-right asymmetric stomach morphogenesis.
Autorzy :
Wyatt BH; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
Amin NM; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
Bagley K; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
Wcisel DJ; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
Dush MK; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.
Yoder JA; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27607, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Nascone-Yoder NM; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27607, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27607, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
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Źródło :
Development (Cambridge, England) [Development] 2021 Sep 01; Vol. 148 (17). Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Morphogenesis*
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Stomach/*embryology
Animals ; Anura ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Body Patterning ; Embryo, Nonmammalian ; Endoderm/embryology ; Endoderm/metabolism ; Gene Expression Regulation, Developmental ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Snail Upregulates Transcription of FN, LEF, COX2, and COL1A1 in Hepatocellular Carcinoma: A General Model Established for Snail to Transactivate Mesenchymal Genes.
Autorzy :
Ly TM; Institute of Medical Sciences, Tzu Chi University, Hualien 970, Taiwan.
Chen YC; Division of General Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Lee MC; Division of General Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Hu CT; Division of Gastroenterology, Department of Medicine, Research Centre for Hepatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Cheng CC; Department of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Chang HH; Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien 970, Taiwan.
You RI; Department of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Wu WS; Division of General Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
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Źródło :
Cells [Cells] 2021 Aug 26; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*genetics
Snail Family Transcription Factors/*metabolism
Carcinoma, Hepatocellular/metabolism ; Cell Line ; Collagen Type I/metabolism ; Cyclooxygenase 2/metabolism ; Fibronectins/metabolism ; Gene Expression/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Lymphoid Enhancer-Binding Factor 1/metabolism ; Mesenchymal Stem Cells/metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding/genetics ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/physiology ; Transcription Factors/metabolism ; Transcriptional Activation/genetics
Czasopismo naukowe
Tytuł :
Delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling.
Autorzy :
Ellert-Miklaszewska A; Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Szymczyk A; Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Poleszak K; Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Kaminska B; Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 07; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Brain Neoplasms/*pathology
Calcineurin/*metabolism
Glioma/*pathology
NFATC Transcription Factors/*metabolism
Oligopeptides/*pharmacology
Amino Acid Sequence ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Brain Neoplasms/genetics ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Cell-Penetrating Peptides/pharmacology ; Glioma/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; NFATC Transcription Factors/chemistry ; Oligopeptides/chemistry ; Peptides/pharmacology ; Protein Transport/drug effects ; Transcription, Genetic/drug effects
Czasopismo naukowe

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