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Tytuł:
Investigation of the impact of bromodomain inhibition on cytoskeleton stability and contraction.
Autorzy:
Bigger-Allen A; Urological Diseases Research Center, Boston Children's Hospital, Enders Bldg 1061.4, 300 Longwood Avenue, Boston, MA, 02115, USA.; Biological & Biomedical Sciences Program, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Gheinani AH; Urological Diseases Research Center, Boston Children's Hospital, Enders Bldg 1061.4, 300 Longwood Avenue, Boston, MA, 02115, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Functional Urology Research Group, Department for BioMedical Research DBMR, University of Bern, Bern, Switzerland.; Department of Urology, Inselspital University Hospital, 3010, Bern, Switzerland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Adam RM; Urological Diseases Research Center, Boston Children's Hospital, Enders Bldg 1061.4, 300 Longwood Avenue, Boston, MA, 02115, USA. .; Department of Surgery, Harvard Medical School, Boston, MA, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Mar 16; Vol. 22 (1), pp. 184. Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Nuclear Proteins*/metabolism
Transcription Factors*/metabolism
Humans ; Cytoskeleton/metabolism ; Myocytes, Smooth Muscle ; Transforming Growth Factor beta/metabolism ; Cells, Cultured
Czasopismo naukowe
Tytuł:
DPPA2/4 Promote the Pluripotency and Proliferation of Bovine Extended Pluripotent Stem Cells by Upregulating the PI3K/AKT/GSK3β/β-Catenin Signaling Pathway.
Autorzy:
Fang S; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
Wang J; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
Liu G; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
Qu B; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
Chunyu J; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
Xu W; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
Xiang J; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
Li X; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China.
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Źródło:
Cells [Cells] 2024 Feb 23; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
beta Catenin*/metabolism
Pluripotent Stem Cells*/metabolism
Transcription Factors*/metabolism
Nuclear Proteins*/metabolism
Animals ; Cattle ; Cell Proliferation ; Glycogen Synthase Kinase 3 beta/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression.
Autorzy:
Madera D; Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Alonso-Gómez A; Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Delgado MJ; Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Valenciano AI; Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Alonso-Gómez ÁL; Departamento de Genética, Fisiología y Microbiología, Universidad Complutense de Madrid, 28040 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 19; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 19.
Typ publikacji:
Journal Article
MeSH Terms:
Goldfish*/genetics
Zebrafish*/genetics
Nuclear Proteins*
Transcription Factors*
Animals ; Phylogeny ; Protein Isoforms/genetics
Czasopismo naukowe
Tytuł:
KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.
Autorzy:
Cai H; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China.; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China.
Liang J; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China.; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China.
Jiang Y; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China.; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China.
Wang Z; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China.; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China.
Li H; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China.; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China.
Wang W; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China.; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China.
Wang C; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China. .; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China. .
Hou J; Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology,, Sun Yat-Sen University, Guangzhou, 51055, China. .; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510080, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Mar 05; Vol. 43 (1), pp. 69. Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*
Head and Neck Neoplasms*/genetics
Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Transcription Factors ; Oncogenes ; Kruppel-Like Transcription Factors/genetics ; RNA-Binding Proteins ; Bromodomain Containing Proteins ; Cell Cycle Proteins
Czasopismo naukowe
Tytuł:
The landscape of SETBP1 gene expression and transcription factor activity across human tissues.
Autorzy:
Whitlock JH; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Wilk EJ; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Howton TC; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Clark AD; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Lasseigne BN; Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0296328. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Carrier Proteins*/genetics
Carrier Proteins*/metabolism
Nuclear Proteins*/genetics
Nuclear Proteins*/metabolism
Humans ; Abnormalities, Multiple/genetics ; Craniofacial Abnormalities/genetics ; Gene Expression ; Intellectual Disability/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Molecular features driving condensate formation and gene expression by the BRD4-NUT fusion oncoprotein are overlapping but distinct.
Autorzy:
Kosno M; Department of Biophysics, Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Currie SL; Department of Biophysics, Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Kumar A; Eugene McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Xing C; Eugene McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Rosen MK; Department of Biophysics, Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, 75390, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 24; Vol. 13 (1), pp. 11907. Date of Electronic Publication: 2023 Jul 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Nuclear Proteins*
Transcription Factors*
Biomolecular Condensates ; Oncogene Proteins, Fusion ; Gene Expression
Czasopismo naukowe
Tytuł:
Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study.
Autorzy:
Kim JH; Research Institute, National Cancer Center, Goyang, Gyeonggi, 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi, 10408, Republic of Korea.
Pandit N; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea.
Yoo M; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
Park TH; Department of Anesthesiology, Weill Cornell Medical College, New York, NY, 10065, USA.
Choi JU; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea.; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
Park CH; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea. .; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. .
Jung KY; Department of Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, 34113, Republic of Korea. .; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. .
Lee BI; Research Institute, National Cancer Center, Goyang, Gyeonggi, 10408, Republic of Korea. .; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi, 10408, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 04; Vol. 13 (1), pp. 10805. Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nuclear Proteins*/metabolism
Transcription Factors*/metabolism
Cell Cycle Proteins/metabolism ; Protein Domains ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
ARID1A loss activates MAPK signaling via DUSP4 downregulation.
Autorzy:
Mandal J; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yu ZC; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shih IM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
Wang TL; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2023 Dec 09; Vol. 30 (1), pp. 94. Date of Electronic Publication: 2023 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*/genetics
Carcinoma, Endometrioid*/genetics
Carcinoma, Endometrioid*/metabolism
Carcinoma, Endometrioid*/pathology
Female ; Humans ; Mice ; Animals ; Down-Regulation ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Mitogen-Activated Protein Kinase Phosphatases/metabolism ; Dual-Specificity Phosphatases/genetics ; Dual-Specificity Phosphatases/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.
Autorzy:
Ozyerli-Goknar E; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK) Partner Site Freiburg, Heidelberg, Germany.; Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.
Kala EY; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.
Aksu AC; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.
Bulut I; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.
Cingöz A; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.
Nizamuddin S; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK) Partner Site Freiburg, Heidelberg, Germany.; Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.
Biniossek M; Institute for Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany.
Seker-Polat F; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.
Morova T; Koç University School of Medicine, Istanbul, Türkiye.; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.
Aztekin C; Koç University School of Medicine, Istanbul, Türkiye.
Kung SHY; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.
Syed H; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.; Koç University School of Medicine, Istanbul, Türkiye.; Biostatistics, Bioinformatics and Data Management Lab, KUTTAM, Istanbul, Türkiye.
Tuncbag N; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.; Koç University School of Medicine, Istanbul, Türkiye.; Department of Chemical and Biological Engineering, Koç University, Istanbul, Türkiye.
Gönen M; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.; Koç University School of Medicine, Istanbul, Türkiye.; Department of Industrial Engineering, Koç University, Istanbul, Türkiye.
Philpott M; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Cribbs AP; Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Acilan C; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.; Koç University School of Medicine, Istanbul, Türkiye.
Lack NA; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.; Koç University School of Medicine, Istanbul, Türkiye.; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.
Onder TT; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye.; Koç University School of Medicine, Istanbul, Türkiye.
Timmers HTM; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK) Partner Site Freiburg, Heidelberg, Germany.; Department of Urology, Medical Center-University of Freiburg, Freiburg, Germany.
Bagci-Onder T; Koç University Research Center for Translational Medicine (KUTTAM), Rumelifeneri Yolu, Sarıyer, Istanbul, 34450, Türkiye. .; Koç University School of Medicine, Istanbul, Türkiye. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Nov 16; Vol. 21 (1), pp. 328. Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nuclear Proteins*/metabolism
Glioblastoma*/genetics
Humans ; Cell Survival ; CRISPR-Cas Systems/genetics ; RNA, Guide, CRISPR-Cas Systems ; DNA-Binding Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Kinesins/genetics ; Kinesins/metabolism
Czasopismo naukowe
Tytuł:
PML Body Biogenesis: A Delicate Balance of Interactions.
Autorzy:
Silonov SA; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Smirnov EY; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Kuznetsova IM; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Turoverov KK; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Fonin AV; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 24; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 24.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Nuclear Proteins*/metabolism
Promyelocytic Leukemia Nuclear Bodies*
Tumor Suppressor Proteins/metabolism ; Promyelocytic Leukemia Protein/genetics ; Promyelocytic Leukemia Protein/chemistry ; Transcription Factors/metabolism ; Tripartite Motif Proteins
Czasopismo naukowe
Tytuł:
Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1.
Autorzy:
Nagakubo D; Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108, Freiburg, Germany.; Division of Health and Hygienic Sciences, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji, Hyogo, 670-8524, Japan.
Hirakawa M; Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108, Freiburg, Germany.; Division of Immunology and Allergy, Research Institute for Biomedical Sciences, Tokyo University of Science, 2669 Yamazaki, Noda-City, Chiba, 278-0022, Japan.
Iwanami N; Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108, Freiburg, Germany.; Center for Bioscience Research and Education, Utsunomiya University, Utsunomiya, Tochigi, 321-8505, Japan.
Boehm T; Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108, Freiburg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 08; Vol. 12 (1), pp. 13554. Date of Electronic Publication: 2022 Aug 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ectopic Gene Expression*
Forkhead Transcription Factors*/genetics
Forkhead Transcription Factors*/metabolism
Nuclear Proteins/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Differentiation ; Epithelium/metabolism ; Mice ; Parathyroid Glands/metabolism ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł:
MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming.
Autorzy:
Mohammed Ismail W; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Mazzone A; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Ghiraldini FG; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kaur J; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Bains M; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Munankarmy A; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Bagwell MS; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Safgren SL; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Moore-Weiss J; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Buciuc M; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Shimp L; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Leach KA; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Duarte LF; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nagi CS; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Carcamo S; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) Shared Resource Facility, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Chung CY; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hasson D; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) Shared Resource Facility, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Dadgar N; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Zhong J; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Lee JH; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Couch FJ; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Revzin A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Ordog T; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA.
Bernstein E; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gaspar-Maia A; Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. .; Center for Individualized Medicine, Epigenomics program, Mayo Clinic, Rochester, MN, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Feb 23; Vol. 6 (1), pp. 215. Date of Electronic Publication: 2023 Feb 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Nuclear Proteins*/metabolism
Transcription Factors*/genetics
Mice ; Animals ; Cellular Reprogramming/genetics ; Enhancer Elements, Genetic ; Chromatin/genetics
Czasopismo naukowe
Tytuł:
BRD4 is involved in viral exacerbation of chronic obstructive pulmonary disease.
Autorzy:
Duan Y; Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, 430030, China.
Zhou S; Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, 430030, China.
Wang J; Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, 430030, China. .
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Źródło:
Respiratory research [Respir Res] 2023 Jan 31; Vol. 24 (1), pp. 37. Date of Electronic Publication: 2023 Jan 31.
Typ publikacji:
Journal Article
MeSH Terms:
Nuclear Proteins*/genetics
Pulmonary Disease, Chronic Obstructive*
Transcription Factors*/genetics
Cell Cycle Proteins*/genetics
Animals ; Mice ; Interleukin-6 ; Interleukin-8 ; Humans
Czasopismo naukowe
Tytuł:
Fucoxanthin inhibits cardiac fibroblast transdifferentiation by alleviating oxidative stress through downregulation of BRD4.
Autorzy:
Han J; Shaoxing Seventh People's Hospital, Shaoxing, China.
Zhang Y; Shaoxing Seventh People's Hospital, Shaoxing, China.
Peng H; Department of pharmacology, Medical college, Shaoxing University, Shaoxing, China.
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Źródło:
PloS one [PLoS One] 2023 Sep 12; Vol. 18 (9), pp. e0291469. Date of Electronic Publication: 2023 Sep 12 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Transdifferentiation*
Nuclear Proteins*/genetics
Angiotensin II/pharmacology ; Down-Regulation ; Fibroblasts ; Kelch-Like ECH-Associated Protein 1/genetics ; NF-E2-Related Factor 2/genetics ; NFI Transcription Factors ; Oxidative Stress ; Reactive Oxygen Species ; Animals ; Rats
Czasopismo naukowe
Tytuł:
BRD4 as a Therapeutic Target in Pulmonary Diseases.
Autorzy:
Guo X; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
Olajuyin A; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
Tucker TA; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
Idell S; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
Qian G; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 25; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Nuclear Proteins*
Pulmonary Disease, Chronic Obstructive*
Humans ; Transcription Factors ; Genes, cdc ; Inflammation ; Cell Cycle Proteins
Czasopismo naukowe
Tytuł:
The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4.
Autorzy:
Primke TF; Institute of Pharmaceutical Biology, Goethe University Frankfurt, 60438 Frankfurt, Germany.; LOEWE Center for Translational Biodiversity Genomics (LOEWE-TBG), Goethe University Frankfurt, 60596 Frankfurt, Germany.
Ingelfinger R; Institute of Pharmaceutical Biology, Goethe University Frankfurt, 60438 Frankfurt, Germany.; LOEWE Center for Translational Biodiversity Genomics (LOEWE-TBG), Goethe University Frankfurt, 60596 Frankfurt, Germany.
Elewa MAF; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60596 Frankfurt, Germany.; Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt.
Macinkovic I; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60596 Frankfurt, Germany.
Weigert A; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt, 60596 Frankfurt, Germany.
Fabritius MP; Department of Otorhinolaryngology, Walter Brendel Centre of Experimental Medicine, University Hospital, 81377 Munich, Germany.; Department of Radiology, University Hospital, University of Munich, 81377 Munich, Germany.
Reichel CA; Department of Otorhinolaryngology, Walter Brendel Centre of Experimental Medicine, University Hospital, 81377 Munich, Germany.
Ullrich A; Institute of Organic Chemistry, Saarland University, 66123 Saarbrücken, Germany.
Kazmaier U; Institute of Organic Chemistry, Saarland University, 66123 Saarbrücken, Germany.
Burgers LD; Institute of Pharmaceutical Biology, Goethe University Frankfurt, 60438 Frankfurt, Germany.
Fürst R; Institute of Pharmaceutical Biology, Goethe University Frankfurt, 60438 Frankfurt, Germany.; LOEWE Center for Translational Biodiversity Genomics (LOEWE-TBG), Goethe University Frankfurt, 60596 Frankfurt, Germany.
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Źródło:
Cells [Cells] 2023 Aug 21; Vol. 12 (16). Date of Electronic Publication: 2023 Aug 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells*
Nuclear Proteins*
Transcription Factors ; Microtubules ; Histone Acetyltransferases
Czasopismo naukowe
Tytuł:
Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins.
Autorzy:
Maksimova V; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Popova V; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Prus A; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Department of Biotechnology and Industrial Pharmacy, Lomonosov Institute of Fine Chemical Technologies, Russian Technological University (MIREA), 86 Vernadsky Avenue, 119571 Moscow, Russia.
Lylova E; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Usalka O; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991 Moscow, Russia.
Sagitova G; Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991 Moscow, Russia.
Zhidkova E; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Makus J; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Trapeznikova E; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Street, 119991 Moscow, Russia.
Belitsky G; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Yakubovskaya M; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.
Kirsanov K; Department of Chemical Carcinogenesis, Institute of Chemical Carcinogenesis, Blokhin National Medical Research Center of Oncology, 24 Kashirskoe Shosse, 115478 Moscow, Russia.; Institute of Medicine, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 17; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Demethylation*
Nuclear Proteins*/genetics
Humans ; Transcription Factors/genetics ; DNA Modification Methylases ; Epigenesis, Genetic ; Cell Cycle Proteins
Czasopismo naukowe
Tytuł:
Pyronaridine as a Bromodomain-Containing Protein 4- N -Terminal Bromodomain (BRD4-BD1) Inhibitor: In Silico Database Mining, Molecular Docking, and Molecular Dynamics Simulation.
Autorzy:
Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.; School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa.
Abdelhamid MMH; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.
Abdeljawaad KAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.
Abdelrahman AHM; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.
Mekhemer GAH; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.
Sidhom PA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.
Sayed SRM; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Paré PW; Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Hegazy MF; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
Shoeib T; Department of Chemistry, The American University in Cairo, New Cairo 11835, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jul 28; Vol. 28 (15). Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Nuclear Proteins*/metabolism
Molecular Docking Simulation ; Bromodomain Containing Proteins ; Transcription Factors/metabolism ; Ligands ; Cell Cycle Proteins/metabolism
Czasopismo naukowe
Tytuł:
Identification of Selective BRD9 Inhibitor via Integrated Computational Approach.
Autorzy:
Ali MM; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Ashraf S; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Nure-E-Alam M; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Qureshi U; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Khan KM; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Ul-Haq Z; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 04; Vol. 23 (21). Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Transcription Factors*/metabolism
Nuclear Proteins*/metabolism
Molecular Dynamics Simulation ; Protein Domains
Czasopismo naukowe
Tytuł:
Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners.
Autorzy:
Diop A; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Pietrangeli P; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Nardella C; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Pennacchietti V; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Pagano L; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Toto A; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Di Felice M; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Di Matteo S; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Marcocci L; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Malagrinò F; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Gianni S; Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 14; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:
Journal Article
MeSH Terms:
Repressor Proteins*/metabolism
Nuclear Proteins*/metabolism
Humans ; Transcription Factors/metabolism ; Ubiquitination
Czasopismo naukowe

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