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Tytuł:
Structural visualization of transcription initiation in action.
Autorzy:
Chen X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Liu W; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wang Q; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wang X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Ren Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Qu X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Li W; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Xu Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec 22; Vol. 382 (6677), pp. eadi5120. Date of Electronic Publication: 2023 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
RNA*/biosynthesis
Transcription Factors, General*/metabolism
Transcription Initiation, Genetic*
DNA-Directed RNA Polymerases/chemistry ; RNA Polymerase II/chemistry ; Humans ; Animals ; Sus scrofa ; Cryoelectron Microscopy ; Motion Pictures
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structures of +1 nucleosome-bound PIC-Mediator complex.
Autorzy:
Chen X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wang X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Liu W; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Ren Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Qu X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Li J; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Yin X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Xu Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.; Human Phenome Institute, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Oct 07; Vol. 378 (6615), pp. 62-68. Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Mediator Complex*/chemistry
Nucleosomes*/chemistry
Transcription Initiation, Genetic*
Chromatin/chemistry ; Humans ; RNA Polymerase II/chemistry ; Transcription Initiation Site
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ReFeaFi: Genome-wide prediction of regulatory elements driving transcription initiation.
Autorzy:
Umarov R; Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.
Li Y; Department of Computer Science and Engineering (CSE), The Chinese University of Hong Kong (CUHK), Hong Kong, People's Republic of China.
Arakawa T; Laboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Takizawa S; Laboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Gao X; King Abdullah University of Science and Technology, Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, Thuwal, Saudi Arabia.
Arner E; Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.; Laboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Sep 07; Vol. 17 (9), pp. e1009376. Date of Electronic Publication: 2021 Sep 07 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Deep Learning*
Models, Genetic*
Regulatory Sequences, Nucleic Acid*
Transcription Initiation, Genetic*
Computational Biology ; Enhancer Elements, Genetic ; Gene Expression Regulation ; Genes, Reporter ; Genome, Human ; Genome-Wide Association Study/statistics & numerical data ; Humans ; Molecular Sequence Annotation ; Mutation ; Promoter Regions, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structures of the human Mediator and Mediator-bound preinitiation complex.
Autorzy:
Chen X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Yin X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Li J; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wu Z; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Qi Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wang X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Liu W; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Xu Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Radiation Oncology, and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China. .; International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.; Human Phenome Institute, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546). Date of Electronic Publication: 2021 May 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription Initiation, Genetic*
Mediator Complex/*chemistry
RNA Polymerase II/*chemistry
Transcription Factor TFIID/*chemistry
Cryoelectron Microscopy ; Cyclin-Dependent Kinases/chemistry ; Cyclin-Dependent Kinases/metabolism ; DNA Helicases/chemistry ; DNA-Binding Proteins/chemistry ; Humans ; Mediator Complex/metabolism ; Mediator Complex Subunit 1/chemistry ; Models, Molecular ; Phosphorylation ; Promoter Regions, Genetic ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Domains ; Protein Folding ; Protein Structure, Quaternary ; Protein Subunits/chemistry ; RNA Polymerase II/metabolism ; Transcription Factor TFIID/metabolism ; Transcription Factor TFIIH/chemistry ; Transcription Factor TFIIH/metabolism ; Cyclin-Dependent Kinase-Activating Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structural insights into preinitiation complex assembly on core promoters.
Autorzy:
Chen X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Qi Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wu Z; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wang X; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Li J; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Zhao D; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Hou H; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Li Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Yu Z; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Liu W; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Wang M; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Ren Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Li Z; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Yang H; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Xu Y; Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering and Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College of Fudan University, Shanghai 200032, China. .; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, China, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China.; Human Phenome Institute, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Apr 30; Vol. 372 (6541). Date of Electronic Publication: 2021 Apr 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*
Transcription Initiation, Genetic*
Multiprotein Complexes/*chemistry
Transcription Factor TFIID/*chemistry
Animals ; Apoptosis Regulatory Proteins/genetics ; Corticotropin-Releasing Hormone/genetics ; Cryoelectron Microscopy ; Cyclin-Dependent Kinases/chemistry ; HEK293 Cells ; Humans ; Phosphorylation ; Protein Binding ; Protein Domains ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-mdm2/genetics ; RNA Polymerase II/chemistry ; Swine ; Urocortins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure of the human Mediator-bound transcription preinitiation complex.
Autorzy:
Abdella R; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA.
Talyzina A; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA.
Chen S; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA.
Inouye CJ; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA, USA.; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.
Tjian R; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. .; Li Ka Shing Center for Biomedical and Health Sciences, University of California, Berkeley, Berkeley, CA, USA.; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.
He Y; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. .; Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, USA.; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University, Chicago, IL, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Apr 02; Vol. 372 (6537), pp. 52-56. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription Initiation, Genetic*
Mediator Complex/*chemistry
RNA Polymerase II/*chemistry
Transcription Factors, General/*chemistry
Binding Sites ; Catalytic Domain ; Cryoelectron Microscopy ; Cyclin-Dependent Kinases/chemistry ; Cyclin-Dependent Kinases/metabolism ; Humans ; Mediator Complex/metabolism ; Models, Molecular ; Phosphorylation ; Protein Binding ; Protein Domains ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Transcription Factor TFIIH/chemistry ; Transcription Factor TFIIH/metabolism ; Transcription Factors, General/metabolism ; Cyclin-Dependent Kinase-Activating Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcription initiation of distant core promoters in a large-sized genome of an insect.
Autorzy:
Liu Q; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China.; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Jiang F; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, China.
Zhang J; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
Li X; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Kang L; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China. .; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, China. .; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. .
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Źródło:
BMC biology [BMC Biol] 2021 Mar 30; Vol. 19 (1), pp. 62. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome, Insect*
Promoter Regions, Genetic*
Transcription Initiation Site*
Transcription Initiation, Genetic*
Locusta migratoria/*genetics
Animals ; Genome Size
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hopping and Flipping of RNA Polymerase on DNA during Recycling for Reinitiation after Intrinsic Termination in Bacterial Transcription.
Autorzy:
Kang W; Department of Physics and Astronomy, and Institute of Applied Physics, Seoul National University, Seoul 08826, Korea.
Hwang S; Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Kang JY; Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Kang C; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Hohng S; Department of Physics and Astronomy, and Institute of Applied Physics, Seoul National University, Seoul 08826, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 27; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Bacterial*
Transcription Initiation, Genetic*
Transcription Termination, Genetic*
DNA, Bacterial/*metabolism
DNA-Directed RNA Polymerases/*metabolism
Escherichia coli/*genetics
Escherichia coli Proteins/*metabolism
DNA, Bacterial/genetics ; DNA-Directed RNA Polymerases/genetics ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Promoter Regions, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.
Autorzy:
Peil K; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010, Tartu, Estonia.
Jürgens H; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010, Tartu, Estonia.
Luige J; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010, Tartu, Estonia.; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Kristjuhan K; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010, Tartu, Estonia.
Kristjuhan A; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010, Tartu, Estonia. .
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Źródło:
Epigenetics & chromatin [Epigenetics Chromatin] 2020 May 27; Vol. 13 (1), pp. 24. Date of Electronic Publication: 2020 May 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription Initiation, Genetic*
Saccharomyces cerevisiae Proteins/*metabolism
Transcription Factor TFIID/*metabolism
Binding Sites ; Histones/metabolism ; Protein Binding ; Protein Domains ; Protein Stability ; RNA Polymerase II/metabolism ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Transcription Factor TFIID/chemistry ; Transcription Factor TFIID/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide RNA pol II initiation and pausing in neural progenitors of the rat.
Autorzy:
Scheidegger A; Department of Biomedical Sciences, University of North Dakota School of Medicine, Grand Forks, ND, 58202, USA.; Present address: Omega Therapeutics, Cambridge, MA, 02139, USA.
Dunn CJ; Molecular and Cell Biology Department, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.
Samarakkody A; Department of Biomedical Sciences, University of North Dakota School of Medicine, Grand Forks, ND, 58202, USA.; Present address: Department of Pediatric Hematology-Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA.
Koney NK; Department of Biomedical Sciences, University of North Dakota School of Medicine, Grand Forks, ND, 58202, USA.
Perley D; Department of Biomedical Sciences, University of North Dakota School of Medicine, Grand Forks, ND, 58202, USA.
Saha RN; Molecular and Cell Biology Department, School of Natural Sciences, University of California Merced, Merced, CA, 95343, USA.
Nechaev S; Department of Biomedical Sciences, University of North Dakota School of Medicine, Grand Forks, ND, 58202, USA. .
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Źródło:
BMC genomics [BMC Genomics] 2019 Jun 11; Vol. 20 (1), pp. 477. Date of Electronic Publication: 2019 Jun 11.
Typ publikacji:
Journal Article
MeSH Terms:
Genomics*
Transcription Initiation, Genetic*
Neural Stem Cells/*metabolism
RNA Polymerase II/*metabolism
Animals ; Female ; Pregnancy ; RNA, Antisense/genetics ; Rats ; Rats, Sprague-Dawley ; Sequence Analysis, RNA ; Transcription Initiation Site
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An integrative approach identifies direct targets of the late viral transcription complex and an expanded promoter recognition motif in Kaposi's sarcoma-associated herpesvirus.
Autorzy:
Nandakumar D; Department of Plant & Microbial Biology, University of California Berkeley, CA, United States of America.; Howard Hughes Medical Institute, Berkeley, CA, United States of America.
Glaunsinger B; Department of Plant & Microbial Biology, University of California Berkeley, CA, United States of America.; Howard Hughes Medical Institute, Berkeley, CA, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2019 May 16; Vol. 15 (5), pp. e1007774. Date of Electronic Publication: 2019 May 16 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Viral*
Promoter Regions, Genetic*
Transcription Initiation, Genetic*
Virus Replication*
Herpesvirus 8, Human/*physiology
Trans-Activators/*metabolism
Viral Proteins/*genetics
DNA, Viral/genetics ; Genome, Viral ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Protein Binding ; RNA Polymerase II/metabolism ; Sarcoma, Kaposi/genetics ; Sarcoma, Kaposi/metabolism ; Sarcoma, Kaposi/virology ; Trans-Activators/genetics ; Viral Proteins/metabolism ; Virus Latency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional interaction of human Ssu72 with RNA polymerase II complexes.
Autorzy:
Spector BM; Department of Biochemistry, University of Iowa, Iowa City, Iowa, United states of America.
Turek ME; Department of Biochemistry, University of Iowa, Iowa City, Iowa, United states of America.
Price DH; Department of Biochemistry, University of Iowa, Iowa City, Iowa, United states of America.
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Źródło:
PloS one [PLoS One] 2019 Mar 22; Vol. 14 (3), pp. e0213598. Date of Electronic Publication: 2019 Mar 22 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Transcription Elongation, Genetic*
Transcription Initiation, Genetic*
Carrier Proteins/*chemistry
RNA Polymerase II/*chemistry
Carrier Proteins/metabolism ; Cyclin-Dependent Kinases/chemistry ; Cyclin-Dependent Kinases/metabolism ; Humans ; Phosphoprotein Phosphatases ; Phosphorylation ; Potassium Chloride/chemistry ; Protein Domains ; RNA Polymerase II/metabolism ; Cyclin-Dependent Kinase-Activating Kinase
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Autorzy:
Patel AB; Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA.; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Louder RK; Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA.; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Greber BJ; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; California Institute for Quantitative Biology (QB3), University of California, Berkeley, CA 94720, USA.
Grünberg S; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Luo J; Institute for Systems Biology, Seattle, WA 98109, USA.
Fang J; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
Liu Y; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA.
Ranish J; Institute for Systems Biology, Seattle, WA 98109, USA.
Hahn S; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Nogales E; Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA. .; Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2018 Dec 21; Vol. 362 (6421). Date of Electronic Publication: 2018 Nov 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*
Transcription Initiation, Genetic*
TATA-Box Binding Protein/*chemistry
Transcription Factor TFIID/*chemistry
Cross-Linking Reagents/chemistry ; Cryoelectron Microscopy ; DNA/chemistry ; DNA/metabolism ; Humans ; Protein Binding ; Protein Domains ; Protein Multimerization ; Protein Stability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.
Autorzy:
Jordan PC; Alios BioPharma, Inc. a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, California, United States of America.
Liu C; Alios BioPharma, Inc. a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, California, United States of America.
Raynaud P; Alios BioPharma, Inc. a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, California, United States of America.
Lo MK; Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Spiropoulou CF; Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Symons JA; Alios BioPharma, Inc. a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, California, United States of America.
Beigelman L; Alios BioPharma, Inc. a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, California, United States of America.
Deval J; Alios BioPharma, Inc. a Janssen Pharmaceutical Company of Johnson & Johnson, South San Francisco, California, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2018 Feb 09; Vol. 14 (2), pp. e1006889. Date of Electronic Publication: 2018 Feb 09 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription Elongation, Genetic*
Transcription Initiation, Genetic*
Transcription Termination, Genetic*
DNA-Directed RNA Polymerases/*metabolism
Nipah Virus/*genetics
Phosphoproteins/*metabolism
Viral Proteins/*metabolism
Amino Acid Sequence ; DNA-Directed RNA Polymerases/chemistry ; DNA-Directed RNA Polymerases/genetics ; Nipah Virus/enzymology ; Paramyxovirinae/enzymology ; Paramyxovirinae/genetics ; Paramyxovirinae/metabolism ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extracytoplasmic Function σ Factors as Tools for Coordinating Stress Responses.
Autorzy:
de Dios R; Departamento de Biología Molecular e Ingeniería Bioquímica, Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía, 41013 Sevilla, Spain.
Santero E; Departamento de Biología Molecular e Ingeniería Bioquímica, Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía, 41013 Sevilla, Spain.
Reyes-Ramírez F; Departamento de Biología Molecular e Ingeniería Bioquímica, Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía, 41013 Sevilla, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 09; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Bacterial Physiological Phenomena*
Stress, Physiological*
Bacteria/*genetics
Bacteria/*metabolism
Sigma Factor/*genetics
Sigma Factor/*metabolism
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Extracellular Space ; Gene Expression Regulation, Bacterial ; Multigene Family ; Protein Binding ; Sigma Factor/classification ; Signal Transduction ; Transcription Initiation, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mediator and TREX-2: Emerging links between transcription initiation and mRNA export.
Autorzy:
Schubert T; a Max F. Perutz Laboratories , Medical University of Vienna , Vienna Biocenter Campus (VBC) , Vienna, Austria.
Köhler A; a Max F. Perutz Laboratories , Medical University of Vienna , Vienna Biocenter Campus (VBC) , Vienna, Austria.
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Źródło:
Nucleus (Austin, Tex.) [Nucleus] 2016 Apr 25; Vol. 7 (2), pp. 126-31. Date of Electronic Publication: 2016 Mar 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
RNA Transport*
Transcription Initiation, Genetic*
Endodeoxyribonucleases/*metabolism
Humans ; Promoter Regions, Genetic/genetics ; RNA Polymerase II/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection.
Autorzy:
Winkelman JT; Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA. Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Vvedenskaya IO; Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA.
Zhang Y; Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Zhang Y; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA.
Bird JG; Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA.
Taylor DM; Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Gourse RL; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Ebright RH; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA. Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA. .
Nickels BE; Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. Waksman Institute, Rutgers University, Piscataway, NJ 08854, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2016 Mar 04; Vol. 351 (6277), pp. 1090-3.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Promoter Regions, Genetic*
Transcription Initiation Site*
Transcription Initiation, Genetic*
Bacteria/*genetics
RNA, Messenger/*biosynthesis
Crystallography, X-Ray ; DNA/chemistry ; DNA/genetics ; Gene Library ; Nucleic Acid Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Molecular Mechanisms of Transcription Initiation at gal Promoters and their Multi-Level Regulation by GalR, CRP and DNA Loop.
Autorzy:
Lewis DE; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. .
Adhya S; Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. .
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Źródło:
Biomolecules [Biomolecules] 2015 Oct 16; Vol. 5 (4), pp. 2782-807. Date of Electronic Publication: 2015 Oct 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Intramural; Review
MeSH Terms:
Promoter Regions, Genetic*
Transcription Initiation, Genetic*
Cyclic AMP Receptor Protein/*metabolism
DNA, Bacterial/*genetics
Escherichia coli Proteins/*metabolism
Repressor Proteins/*metabolism
Base Sequence ; Cyclic AMP Receptor Protein/genetics ; DNA, Bacterial/chemistry ; Escherichia coli Proteins/genetics ; Galactose/genetics ; Galactose/metabolism ; Gene Expression Regulation, Bacterial ; Molecular Sequence Data ; Operon ; Repressor Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Autorzy:
Wiesner T; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Dermatology, Medical University of Graz, 8010 Graz, Austria.
Lee W; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Obenauf AC; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Ran L; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Murali R; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Zhang QF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Wong EW; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Hu W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Scott SN; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Shah RH; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Landa I; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Button J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Lailler N; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Sboner A; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/New York Presbyterian Hospital, New York 10065, USA.; Institute for Computational Biomedicine, Weill Cornell Medical College/New York Presbyterian Hospital, New York 10065, USA.; Institute for Precision Medicine, Weill Cornell Medical College/New York Presbyterian Hospital, New York, USA.
Gao D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Murphy DA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Cao Z; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Shukla S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Hollmann TJ; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Wang L; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Borsu L; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Merghoub T; Immunology Program, Memorial Sloan Kettering Cancer Center 10065, New York, USA.
Schwartz GK; Herbert Irving Comprehensive Cancer Center, Columbia University Cancer Center, New York 10032, USA.
Postow MA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York 10065, USA.
Ariyan CE; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Fagin JA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York 10065, USA.
Zheng D; Department of Neurology, Albert Einstein College of Medicine, New York 10461, USA.; Department of Genetics, Albert Einstein College of Medicine, New York 10461, USA.; Department of Neuroscience, Albert Einstein College of Medicine, New York 10461, USA.
Ladanyi M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Busam KJ; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Berger MF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York 10065, USA.
Chen Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York 10065, USA.
Chi P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York 10065, USA.; Department of Medicine, Weill Cornell Medical College, New York 10065, USA.
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Źródło:
Nature [Nature] 2015 Oct 15; Vol. 526 (7573), pp. 453-7. Date of Electronic Publication: 2015 Oct 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Transcription Initiation, Genetic*
Gene Expression Regulation, Neoplastic/*genetics
Neoplasms/*enzymology
Neoplasms/*genetics
Receptor Protein-Tyrosine Kinases/*genetics
Alleles ; Anaplastic Lymphoma Kinase ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic ; Female ; HEK293 Cells ; Histones/chemistry ; Histones/metabolism ; Humans ; Introns/genetics ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/biosynthesis ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Lysine/metabolism ; Methylation ; Mice ; Molecular Sequence Data ; Molecular Weight ; NIH 3T3 Cells ; Neoplasms/drug therapy ; Oncogenes/genetics ; Protein Structure, Tertiary/genetics ; RNA Polymerase II/metabolism ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/biosynthesis ; Receptor Protein-Tyrosine Kinases/chemistry ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genome-Scale Mapping of Escherichia coli σ54 Reveals Widespread, Conserved Intragenic Binding.
Autorzy:
Bonocora RP; Wadsworth Center, New York State Department of Health, Albany, New York, United States of America.
Smith C; Wadsworth Center, New York State Department of Health, Albany, New York, United States of America.
Lapierre P; Wadsworth Center, New York State Department of Health, Albany, New York, United States of America.
Wade JT; Wadsworth Center, New York State Department of Health, Albany, New York, United States of America; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2015 Oct 01; Vol. 11 (10), pp. e1005552. Date of Electronic Publication: 2015 Oct 01 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Genome, Bacterial*
Transcription Initiation, Genetic*
Escherichia coli/*genetics
Escherichia coli Proteins/*genetics
RNA Polymerase Sigma 54/*genetics
Binding Sites ; DNA-Binding Proteins/genetics ; Promoter Regions, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 86

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