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Wyszukujesz frazę ""Transcriptional Activation"" wg kryterium: Temat


Tytuł :
Characterization of the transactivation and nuclear localization functions of Pichia pastoris zinc finger transcription factor Mxr1p.
Autorzy :
Gupta A; Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Krishna Rao K; Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Sahu U; Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Rangarajan PN; Department of Biochemistry, Indian Institute of Science, Bangalore, India. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101247. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
Transcriptional Activation*
Cell Nucleus/*metabolism
Fungal Proteins/*metabolism
Saccharomycetales/*metabolism
Transcription Factors/*metabolism
Active Transport, Cell Nucleus/genetics ; Cell Nucleus/genetics ; Fungal Proteins/genetics ; Saccharomycetales/genetics ; Transcription Factors/genetics ; Zinc Fingers
SCR Organism :
Komagataella pastoris
Czasopismo naukowe
Tytuł :
Spatial control of gene expression in flies using bacterially derived binary transactivation systems.
Autorzy :
Gamez S; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, California, USA.
Vesga LC; Group for Research in Biochemistry and Microbiology (Grupo de Investigación en Bioquímica Y Microbiología-GIBIM), School of Chemistry, Universidad Industrial de Santander, Bucaramanga, Colombia.
Mendez-Sanchez SC; Group for Research in Biochemistry and Microbiology (Grupo de Investigación en Bioquímica Y Microbiología-GIBIM), School of Chemistry, Universidad Industrial de Santander, Bucaramanga, Colombia.
Akbari OS; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, California, USA.
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Źródło :
Insect molecular biology [Insect Mol Biol] 2021 Oct; Vol. 30 (5), pp. 461-471. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Bacterial Proteins*/genetics
Drosophila melanogaster*/genetics
Gene Expression Regulation*
Operon*
Transcriptional Activation*
Animals
Czasopismo naukowe
Tytuł :
Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B.
Autorzy :
Yoo CY; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
He J; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Sang Q; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.; Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Qiu Y; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Long L; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Kim RJ; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Chong EG; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Hahm J; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Morffy N; Department of Biology, Duke University, Durham, NC, USA.
Zhou P; Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
Strader LC; Department of Biology, Duke University, Durham, NC, USA.
Nagatani A; Department of Botany, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, Japan.
Mo B; Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Chen X; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA.
Chen M; Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 23; Vol. 12 (1), pp. 5614. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arabidopsis/*genetics
Arabidopsis Proteins/*genetics
Basic Helix-Loop-Helix Transcription Factors/*genetics
Phytochrome B/*genetics
Transcriptional Activation/*genetics
Tumor Suppressor Protein p53/*genetics
Amino Acid Sequence ; Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Binding Sites/genetics ; Gene Expression Regulation, Plant/radiation effects ; Models, Genetic ; Phytochrome A/genetics ; Phytochrome A/metabolism ; Phytochrome B/metabolism ; Plants, Genetically Modified ; Protein Binding/radiation effects ; Sequence Homology, Amino Acid ; Transcriptional Activation/radiation effects ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1.
Autorzy :
Wang M; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.; Department of Cell and Neurobiology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Liu H; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.
Zhang X; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.
Zhao W; Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Li D; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.; Department of Rehabilitation, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Xu C; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.
Wu Z; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.
Xie F; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.
Li X; Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Advanced Medical Research Institute, Shandong University, Qingdao, Shandong, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Sep; Vol. 236 (9), pp. 6559-6570. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Histone Acetyltransferases/*metabolism
Insulin-Like Growth Factor I/*genetics
Liver/*injuries
Liver/*metabolism
Transcriptional Activation/*genetics
Acute Disease ; Adenoviridae/metabolism ; Animals ; Carbon Tetrachloride ; Cell Line, Tumor ; Gene Knockdown Techniques ; Imidazoles/pharmacology ; Insulin-Like Growth Factor I/metabolism ; Liver/drug effects ; Liver/pathology ; Liver Regeneration/drug effects ; Liver Regeneration/genetics ; Male ; Mice, Inbred C57BL ; Promoter Regions, Genetic/genetics ; Protein Binding/drug effects ; Pyrazines/pharmacology ; Signal Transduction/drug effects ; Transcriptional Activation/drug effects
Czasopismo naukowe
Tytuł :
YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation.
Autorzy :
He L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
Pratt H; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States.
Gao M; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States.
Wei F; Genetics Laboratory, Shenzhen Longgang District Maternity and Child Healthcare Hospital, Shenzhen, China.
Weng Z; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, United States.
Struhl K; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
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Źródło :
ELife [Elife] 2021 Aug 31; Vol. 10. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transcriptional Activation*
Adaptor Proteins, Signal Transducing/*metabolism
Cell Transformation, Neoplastic/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
STAT3 Transcription Factor/*metabolism
Transcription Factor AP-1/*metabolism
Transcription Factors/*metabolism
Triple Negative Breast Neoplasms/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Databases, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Protein Binding ; Protein Interaction Domains and Motifs ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Transcription Factor AP-1/genetics ; Transcription Factors/genetics ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Crucial role of Salmonella genomic island 1 master activator in the parasitism of IncC plasmids.
Autorzy :
Durand R; Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Huguet KT; Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Rivard N; Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Carraro N; Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Rodrigue S; Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Burrus V; Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Aug 20; Vol. 49 (14), pp. 7807-7824.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Conjugation, Genetic/*genetics
Genomic Islands/*genetics
Plasmids/*genetics
Salmonella/*genetics
Bacterial Proteins/genetics ; DNA Replication/genetics ; Drug Resistance, Multiple, Bacterial/genetics ; Gammaproteobacteria/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Bacterial ; Models, Genetic ; Promoter Regions, Genetic/genetics ; RNA-Seq/methods
Czasopismo naukowe
Tytuł :
Design and Evaluation of Synthetic RNA-Based Incoherent Feed-Forward Loop Circuits.
Autorzy :
Hong S; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
Jeong D; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
Ryan J; Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
Foo M; School of Engineering, University of Warwick, Coventry CV4 7AL, UK.
Tang X; Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
Kim J; Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
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Źródło :
Biomolecules [Biomolecules] 2021 Aug 10; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Escherichia coli/*genetics
Proteins/*metabolism
RNA/*metabolism
Synthetic Biology/*methods
Gene Regulatory Networks
Czasopismo naukowe
Tytuł :
Glioblastoma invasion factor ODZ1 is induced by microenvironmental signals through activation of a Stat3-dependent transcriptional pathway.
Autorzy :
Vidal V; Genetics Unit, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda. Valdecilla s/n, 39008, Santander, Spain.
Gutierrez O; Genetics Unit, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda. Valdecilla s/n, 39008, Santander, Spain.
Talamillo A; Genetics Unit, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda. Valdecilla s/n, 39008, Santander, Spain.
Velasquez C; Neurosurgery Service, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Marqués de Valdecilla (IDIVAL), 39008, Santander, Spain.
Fernandez-Luna JL; Genetics Unit, Hospital Universitario Marqués de Valdecilla and Instituto de Investigación Marqués de Valdecilla (IDIVAL), Avda. Valdecilla s/n, 39008, Santander, Spain. .
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Źródło :
Scientific reports [Sci Rep] 2021 Aug 10; Vol. 11 (1), pp. 16196. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Transcriptional Activation*
Tumor Microenvironment*
Glioblastoma/*pathology
Interleukin-6/*metabolism
Nerve Tissue Proteins/*metabolism
STAT3 Transcription Factor/*metabolism
Tenascin/*metabolism
Cell Movement ; Glioblastoma/genetics ; Glioblastoma/immunology ; Glioblastoma/metabolism ; Humans ; Nerve Tissue Proteins/genetics ; Promoter Regions, Genetic ; Receptors, Interleukin-6/metabolism ; STAT3 Transcription Factor/genetics ; Signal Transduction ; Tenascin/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Transcriptional activation of SUGAR TRANSPORT PROTEIN 13 mediates biotic and abiotic stress signaling.
Autorzy :
Lee HG; Department of Chemistry, Seoul National University, Seoul, Korea.; Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea.
Seo PJ; Department of Chemistry, Seoul National University, Seoul, Korea.; Plant Genomics and Breeding Institute, Seoul National University, Seoul, Korea.
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Źródło :
Plant signaling & behavior [Plant Signal Behav] 2021 Aug 03; Vol. 16 (8), pp. 1920759. Date of Electronic Publication: 2021 Apr 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Adaptation, Physiological/*genetics
Arabidopsis/*physiology
Arabidopsis Proteins/*metabolism
Disease Resistance/*genetics
Monosaccharide Transport Proteins/*genetics
Stress, Physiological/*genetics
Transcription Factors/*metabolism
Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis/microbiology ; Arabidopsis Proteins/genetics ; Biological Transport ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Gene Expression Regulation, Plant ; Monosaccharide Transport Proteins/metabolism ; Signal Transduction ; Sugars/metabolism
Czasopismo naukowe
Tytuł :
CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
Autorzy :
Duan J; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, United States.
Rieder L; Department of Biology, Emory University, Atlanta, United States.
Colonnetta MM; Department of Molecular Biology, Princeton University, Princeton, United States.
Huang A; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, United States.
Mckenney M; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, United States.
Watters S; Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, United States.
Deshpande G; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, United States.; Department of Molecular Biology, Princeton University, Princeton, United States.
Jordan W; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, United States.
Fawzi N; Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, United States.
Larschan E; Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, United States.
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Źródło :
ELife [Elife] 2021 Aug 03; Vol. 10. Date of Electronic Publication: 2021 Aug 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genome, Insect*
Transcriptional Activation*
DNA-Binding Proteins/*genetics
Drosophila Proteins/*genetics
Drosophila melanogaster/*genetics
Nuclear Proteins/*genetics
Animals ; Base Sequence ; DNA-Binding Proteins/metabolism ; Drosophila Proteins/metabolism ; Nuclear Proteins/metabolism ; Zygote/metabolism
Czasopismo naukowe
Tytuł :
Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.
Autorzy :
Song CC; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Chen GH; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Zhong CC; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Chen F; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Chen SW; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China.
Luo Z; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Fishery College, Huazhong Agricultural University, Wuhan 430070, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2021 Aug; Vol. 1864 (8), pp. 194723. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Catfishes/*genetics
Cation Transport Proteins/*genetics
Fish Proteins/*genetics
Zinc/*metabolism
Animals ; Binding Sites ; Catfishes/metabolism ; Cation Transport Proteins/metabolism ; Cells, Cultured ; DNA-Binding Proteins/metabolism ; Fish Proteins/metabolism ; HEK293 Cells ; Homeostasis ; Humans ; Mutation ; Promoter Regions, Genetic ; RNA, Messenger/metabolism ; STAT3 Transcription Factor/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Reactivation of a developmentally silenced embryonic globin gene.
Autorzy :
King AJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Songdej D; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Division of Hematology/Oncology, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Downes DJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Beagrie RA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Liu S; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Buckley M; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Hua P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Suciu MC; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Marieke Oudelaar A; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Hanssen LLP; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Jeziorska D; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Roberts N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Carpenter SJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Francis H; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Telenius J; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Olijnik AA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Sharpe JA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Sloane-Stanley J; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Eglinton J; National Haemoglobinopathy Reference Laboratory, Department of Haematology, Level 4, John Radcliffe Hospital, Oxford, UK.
Kassouf MT; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Orkin SH; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA.
Pennacchio LA; Functional Genomics Department, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA, USA.
Davies JOJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Hughes JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Higgs DR; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. .
Babbs C; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 21; Vol. 12 (1), pp. 4439. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Expression Regulation, Developmental*/drug effects
Gene Silencing*/drug effects
Transcriptional Activation*/drug effects
zeta-Globins/*genetics
Acetylation ; Animals ; Chromatin/metabolism ; DNA-Binding Proteins/metabolism ; Enhancer Elements, Genetic ; Erythroid Cells/metabolism ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Mice ; Repressor Proteins/metabolism ; Transcription Factors/metabolism ; alpha-Globins/genetics
Czasopismo naukowe
Tytuł :
Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer.
Autorzy :
Cheng CL; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Tsang FH; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Wei L; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Chen M; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Chin DW; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Shen J; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Law CT; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Lee D; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Wong CC; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Ng IO; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong.; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Wong CM; State Key Laboratory of Liver Research, The University of Hong Kong, Pok Fu Lam, Hong Kong. .; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong. .
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Źródło :
Communications biology [Commun Biol] 2021 Jul 20; Vol. 4 (1), pp. 888. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Adaptor Proteins, Signal Transducing/*genetics
Carcinoma, Hepatocellular/*drug therapy
DNA-Binding Proteins/*genetics
Liver Neoplasms/*drug therapy
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Carcinoma, Hepatocellular/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Liver Neoplasms/genetics ; Male ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch.
Autorzy :
Kaji DA; Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Montero AM; Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Patel R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Huang AH; Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 09; Vol. 12 (1), pp. 4208. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcriptional Activation*
Fibrocartilage/*growth & development
Mouse Embryonic Stem Cells/*physiology
Tendons/*growth & development
Tissue Engineering/*methods
Animals ; Cell Differentiation/genetics ; Embryo, Mammalian ; Fibrocartilage/cytology ; Gene Expression Regulation, Developmental ; Hedgehog Proteins/metabolism ; Mechanotransduction, Cellular/genetics ; Mice ; RNA-Seq ; Signal Transduction/genetics ; Single-Cell Analysis ; Tendons/cytology ; Transforming Growth Factor beta/metabolism ; Tretinoin/metabolism
Czasopismo naukowe
Tytuł :
Screening of the HBx transactivation domain interacting proteins and the function of interactor Pin1 in HBV replication.
Autorzy :
Zhou Q; Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, No. 17 Third Renmin Road North, Chengdu, 610041, People's Republic of China.
Yan L; Center of Infectious Diseases, West China Hospital of Sichuan University, No.37 Guo Xue Xiang, Chengdu, 610041, People's Republic of China.; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, People's Republic of China.
Xu B; Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, No. 17 Third Renmin Road North, Chengdu, 610041, People's Republic of China.; Xinxiang Key Laboratory of Forensic Science Evidence, School of Forensic Medicine, Xinxiang Medical University, Xinxiang, 453003, People's Republic of China.
Wang X; Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, No. 17 Third Renmin Road North, Chengdu, 610041, People's Republic of China.
Sun X; Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, No. 17 Third Renmin Road North, Chengdu, 610041, People's Republic of China.
Han N; Center of Infectious Diseases, West China Hospital of Sichuan University, No.37 Guo Xue Xiang, Chengdu, 610041, People's Republic of China.; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, People's Republic of China.
Tang H; Center of Infectious Diseases, West China Hospital of Sichuan University, No.37 Guo Xue Xiang, Chengdu, 610041, People's Republic of China. .; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, 610041, People's Republic of China. .
Huang F; Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, No. 17 Third Renmin Road North, Chengdu, 610041, People's Republic of China. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jul 08; Vol. 11 (1), pp. 14176. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Hepatitis B virus/*physiology
NIMA-Interacting Peptidylprolyl Isomerase/*metabolism
Trans-Activators/*chemistry
Trans-Activators/*metabolism
Viral Regulatory and Accessory Proteins/*chemistry
Viral Regulatory and Accessory Proteins/*metabolism
Virus Replication/*physiology
Hep G2 Cells ; Humans ; Protein Binding ; Protein Domains ; Protein Interaction Maps ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
Autorzy :
Bag I; Nuclear Organization and Gene Expression Section, Bethesda, MD, USA.; Laboratory of Biochemistry and Genetics, Bethesda, MD, USA.
Chen S; Nuclear Organization and Gene Expression Section, Bethesda, MD, USA.; Laboratory of Biochemistry and Genetics, Bethesda, MD, USA.
Rosin LF; Nuclear Organization and Gene Expression Section, Bethesda, MD, USA.; Laboratory of Biochemistry and Genetics, Bethesda, MD, USA.
Chen Y; Nuclear Organization and Gene Expression Section, Bethesda, MD, USA.; Laboratory of Biochemistry and Genetics, Bethesda, MD, USA.
Liu CY; Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Yu GY; Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Lei EP; Nuclear Organization and Gene Expression Section, Bethesda, MD, USA. .; Laboratory of Biochemistry and Genetics, Bethesda, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 07; Vol. 12 (1), pp. 4170. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Transcriptional Activation*
Drosophila Proteins/*metabolism
Drosophila melanogaster/*genetics
Microtubule-Associated Proteins/*metabolism
Nuclear Proteins/*metabolism
Repressor Proteins/*metabolism
Transcription Factors/*metabolism
Animals ; Animals, Genetically Modified ; Cell Line ; Cell Nucleus/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Immunoprecipitation Sequencing ; Drosophila Proteins/genetics ; Gene Knockdown Techniques ; Genome, Insect ; Insulator Elements/genetics ; Male ; Microtubule-Associated Proteins/genetics ; Nuclear Proteins/genetics ; Promoter Regions, Genetic/genetics ; RNA-Seq ; Repressor Proteins/genetics ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Chromatin-embedded reporter genes: Quantification of stimulus-induced gene transcription.
Autorzy :
Thiel G; Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany. Electronic address: .
Backes TM; Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany.
Guethlein LA; Department of Structural Biology and Department of Microbiology & Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Rössler OG; Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany.
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Źródło :
Gene [Gene] 2021 Jun 30; Vol. 787, pp. 145645. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genes, Reporter*
Transcriptional Activation*
Chromatin/*genetics
Transcription Factors/*metabolism
Animals ; Cyclic AMP Response Element-Binding Protein/metabolism ; Early Growth Response Protein 1/metabolism ; Gene Expression Regulation ; Humans ; NF-kappa B/metabolism ; NFATC Transcription Factors/metabolism ; Signal Transduction ; Transcription Factor AP-1/metabolism ; ets-Domain Protein Elk-1/metabolism
Czasopismo naukowe
Tytuł :
Gawky modulates MTF-1-mediated transcription activation and metal discrimination.
Autorzy :
Jia R; School of Life Sciences, Chongqing University, Chongqing 401331, China.; Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing 401331, China.
Song Z; School of Life Sciences, Chongqing University, Chongqing 401331, China.; Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing 401331, China.
Lin J; School of Life Sciences, Chongqing University, Chongqing 401331, China.; Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing 401331, China.
Li Z; School of Life Sciences, Chongqing University, Chongqing 401331, China.; Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing 401331, China.
Shan G; School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.
Huang C; School of Life Sciences, Chongqing University, Chongqing 401331, China.; Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing 401331, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jun 21; Vol. 49 (11), pp. 6296-6314.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
DNA-Binding Proteins/*metabolism
Drosophila Proteins/*metabolism
Drosophila melanogaster/*genetics
Metals/*toxicity
Transcription Factors/*metabolism
Active Transport, Cell Nucleus ; Animals ; Cell Line ; Cell Nucleus/metabolism ; Copper/toxicity ; Drosophila Proteins/genetics ; Drosophila Proteins/physiology ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/metabolism ; Metallothionein/genetics ; Promoter Regions, Genetic ; RNA Interference ; RNA Splicing ; Stress, Physiological/genetics
Czasopismo naukowe
Tytuł :
Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene.
Autorzy :
Popp AP; Institute of Biophysics, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Hettich J; Institute of Biophysics, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Gebhardt JCM; Institute of Biophysics, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jun 21; Vol. 49 (11), pp. 6249-6266.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Transcription Factors/*metabolism
Cell Line ; DNA/metabolism ; Genes, Reporter ; Kinetics ; Transcription Activator-Like Effectors/chemistry ; Transcription Factors/chemistry ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
ERK-mediated transcriptional activation of Dicer is involved in gemcitabine resistance of pancreatic cancer.
Autorzy :
Su YH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of General Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Hsu TW; Department of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen HA; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of General Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Su CM; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of General Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Huang MT; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of General Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Chuang TH; School of Pharmacy, China Medical University, Taichung, Taiwan.
Leo Su J; Department of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Hsieh CL; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Chiu CF; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan.; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Jun; Vol. 236 (6), pp. 4420-4434. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*/genetics
Transcriptional Activation*
Antimetabolites, Antineoplastic/*pharmacology
Carcinoma, Pancreatic Ductal/*drug therapy
DEAD-box RNA Helicases/*metabolism
Deoxycytidine/*analogs & derivatives
Extracellular Signal-Regulated MAP Kinases/*metabolism
Pancreatic Neoplasms/*drug therapy
Ribonuclease III/*metabolism
Animals ; Carcinoma, Pancreatic Ductal/enzymology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; DEAD-box RNA Helicases/genetics ; Deoxycytidine/pharmacology ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Inbred NOD ; Mice, SCID ; Pancreatic Neoplasms/enzymology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Ribonuclease III/genetics ; Signal Transduction ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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