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Wyszukujesz frazę ""Transcriptional Activation"" wg kryterium: Temat


Tytuł :
Transcriptional regulation of Treg homeostasis and functional specification.
Autorzy :
Wang K; Pediatric Diabetes Research Center, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Fu W; Pediatric Diabetes Research Center, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. .; Moores Cancer Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Nov; Vol. 77 (21), pp. 4269-4287. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Transcriptional Activation*
T-Lymphocytes, Regulatory/*metabolism
Animals ; Epigenesis, Genetic ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Signal Transduction ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/pathology ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors.
Autorzy :
Horisawa K; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Udono M; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Ueno K; Genome Medical Science Project, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Ohkawa Y; Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Nagasaki M; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; Human Biosciences Unit for the Top Global Course, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606-8507, Japan.
Sekiya S; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Suzuki A; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Aug 20; Vol. 79 (4), pp. 660-676.e8. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Hepatocyte Nuclear Factor 3-gamma/*metabolism
Hepatocyte Nuclear Factor 4/*metabolism
Liver/*cytology
Liver/*physiology
Animals ; Binding Sites ; Cells, Cultured ; Cellular Reprogramming/physiology ; Chromatin/metabolism ; DNA Polymerase II/genetics ; DNA Polymerase II/metabolism ; Fibroblasts/cytology ; Fibroblasts/physiology ; Gene Expression Regulation ; Hepatocyte Nuclear Factor 3-gamma/genetics ; Hepatocyte Nuclear Factor 4/genetics ; Mice, Inbred C57BL ; Protein Domains ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function.
Autorzy :
Fox S; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Myers JA; Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 14642, USA.; Genomics Research Center, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Davidson C; Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Getman M; Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Kingsley PD; Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Frankiewicz N; Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Bulger M; Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 14642, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 11; Vol. 11 (1), pp. 4544. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transcriptional Activation*
Chromatin/*metabolism
Enhancer Elements, Genetic/*genetics
Genetic Loci/*genetics
Acetylation ; Animals ; Cell Line, Tumor ; Chromatin Immunoprecipitation ; Chromatin Immunoprecipitation Sequencing ; Datasets as Topic ; Embryo, Mammalian ; Erythroblasts ; Female ; Fetus ; Histone Code/genetics ; Histones/genetics ; Histones/metabolism ; Humans ; Mice ; Promoter Regions, Genetic/genetics ; RNA-Seq
Czasopismo naukowe
Tytuł :
Multiple domains in the 50 kDa form of E4F1 regulate promoter-specific repression and E1A trans-activation.
Autorzy :
Rooney RJ; Department of Genetics, Duke University Medical Center, Durham, NC, USA. Electronic address: .
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Źródło :
Gene [Gene] 2020 Sep 05; Vol. 754, pp. 144882. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Promoter Regions, Genetic*
Transcriptional Activation*
Adenovirus E1A Proteins/*genetics
Repressor Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Adenovirus E1A Proteins/metabolism ; Binding Sites ; HEK293 Cells ; HeLa Cells ; Humans ; Phosphorylation ; Protein Domains ; Repressor Proteins/genetics ; Transcription, Genetic ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors.
Autorzy :
Ge M; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
Li D; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
Qiao Z; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240, Shanghai, China.
Sun Y; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
Kang T; Department of Oncology, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, 200092, Shanghai, China.
Zhu S; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
Wang S; Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 350001, Fuzhou, China.
Xiao H; State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240, Shanghai, China.
Zhao C; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China.
Shen S; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Department of Hematology & Oncology, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 200127, Shanghai, China. .
Xu Z; Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, 350001, Fuzhou, China. .
Liu H; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. .
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Źródło :
Oncogene [Oncogene] 2020 Sep; Vol. 39 (36), pp. 5888-5901. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Drug Resistance, Neoplasm/*genetics
Myeloid-Lymphoid Leukemia Protein/*genetics
Proteasome Inhibitors/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Cellular Reprogramming/genetics ; Chromatin Assembly and Disassembly/drug effects ; Chromatin Assembly and Disassembly/genetics ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Dose-Response Relationship, Drug ; Drug Synergism ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Mice ; Models, Biological ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism
Czasopismo naukowe
Tytuł :
ATAC-seq footprinting unravels kinetics of transcription factor binding during zygotic genome activation.
Autorzy :
Bentsen M; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Goymann P; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Schultheis H; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Klee K; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Petrova A; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Wiegandt R; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Fust A; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Preussner J; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 60596, Frankfurt am Main, Germany.
Kuenne C; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Braun T; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 60596, Frankfurt am Main, Germany.; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Kim J; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 60596, Frankfurt am Main, Germany.; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany.
Looso M; Bioinformatics Core Unit (BCU), Max Planck Institute for Heart and Lung Research, 61231, Bad Nauheim, Germany. .; German Centre for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 60596, Frankfurt am Main, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 26; Vol. 11 (1), pp. 4267. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Chromatin Immunoprecipitation Sequencing/*methods
Transcription Factors/*metabolism
Zygote/*metabolism
Animals ; Binding Sites/genetics ; Embryonic Development/genetics ; Epigenesis, Genetic ; Female ; Genome, Human ; Homeodomain Proteins/metabolism ; Humans ; Kinetics ; Mice ; Promoter Regions, Genetic ; Proof of Concept Study ; Protein Binding/genetics ; Species Specificity
Czasopismo naukowe
Tytuł :
Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes.
Autorzy :
Jung H; Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul, Republic of Korea.
Seo SB; Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul, Republic of Korea.
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Źródło :
PloS one [PLoS One] 2020 Jul 27; Vol. 15 (7), pp. e0236403. Date of Electronic Publication: 2020 Jul 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*genetics
Jumonji Domain-Containing Histone Demethylases/*metabolism
Transcriptional Activation/*genetics
Amino Acids/deficiency ; Autophagy/drug effects ; Epigenesis, Genetic/drug effects ; HCT116 Cells ; HEK293 Cells ; Histones/metabolism ; Humans ; Promoter Regions, Genetic ; Proteasome Endopeptidase Complex/metabolism ; Protein Processing, Post-Translational/drug effects ; Proteolysis/drug effects ; Sirolimus/pharmacology ; Transcriptional Activation/drug effects ; Valosin Containing Protein/metabolism
Czasopismo naukowe
Tytuł :
Transactivation of SOX5 by Brachyury promotes breast cancer bone metastasis.
Autorzy :
Chen M; Department of Orthopeadic Surgery, Suzhou, Jiangsu, People's Republic of China.
Zou S; Suzhou Cancer Center Core Laboratory, Suzhou, Jiangsu, People's Republic of China.
He C; Suzhou Cancer Center Core Laboratory, Suzhou, Jiangsu, People's Republic of China.
Zhou J; Suzhou Cancer Center Core Laboratory, Suzhou, Jiangsu, People's Republic of China.
Li S; Department of Orthopeadic Surgery, Suzhou, Jiangsu, People's Republic of China.
Shen M; Department of Pathology, the Affiliated Suzhou Hospital of Nanjing Medical University; Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China.
Cheng R; Department of Pathology, the Affiliated Suzhou Hospital of Nanjing Medical University; Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China.
Wang D; Department of Orthopeadic Surgery, Suzhou, Jiangsu, People's Republic of China.
Zou T; Department of Orthopeadic Surgery, Suzhou, Jiangsu, People's Republic of China.
Yan X; Suzhou Cancer Center Core Laboratory, Suzhou, Jiangsu, People's Republic of China.
Huang Y; Department of Ultrasonography, the Fifth People's Hospital of Suzhou, Suzhou, Jiangsu, People's Republic of China.
Shen J; Department of Orthopeadic Surgery, Suzhou, Jiangsu, People's Republic of China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (5), pp. 551-560.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Transcriptional Activation*
Biomarkers, Tumor/*metabolism
Bone Neoplasms/*secondary
Breast Neoplasms/*pathology
Fetal Proteins/*metabolism
SOXD Transcription Factors/*genetics
T-Box Domain Proteins/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Adhesion ; Cell Movement ; Cell Proliferation ; Disease Progression ; Epithelial-Mesenchymal Transition ; Female ; Fetal Proteins/genetics ; Humans ; Mice ; Mice, Nude ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Prognosis ; SOXD Transcription Factors/metabolism ; Survival Rate ; T-Box Domain Proteins/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
EEF1A1 deacetylation enables transcriptional activation of remyelination.
Autorzy :
Duman M; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.; Department of Biology, Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany.
Vaquié A; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.
Nocera G; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.; Department of Biology, Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany.
Heller M; Proteomics and Mass Spectrometry Core Facility, Department for BioMedical Research, University of Bern, Freiburgstrasse 15, 3010, Bern, Switzerland.
Stumpe M; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.
Siva Sankar D; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.
Dengjel J; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.
Meijer D; Center for Discovery Brain Sciences, Edinburgh Medical School, University of Edinburgh, 15 George Square, Edinburgh, EH8 9XD, United Kingdom.
Yamaguchi T; FMI for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058, Basel, Switzerland.
Matthias P; FMI for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058, Basel, Switzerland.
Zeis T; Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031, Basel, Switzerland.
Schaeren-Wiemers N; Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031, Basel, Switzerland.
Hayoz A; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.
Ruff S; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.
Jacob C; Department of Biology, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland. .; Department of Biology, Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 15, 55128, Mainz, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 09; Vol. 11 (1), pp. 3420. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Elongation Factor 1/*metabolism
Remyelination/*genetics
Transcriptional Activation/*genetics
Acetylation ; Aging/metabolism ; Animals ; Cell Dedifferentiation/drug effects ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 2/metabolism ; Lysine Acetyltransferase 5/metabolism ; Mice ; Models, Biological ; Oligodendroglia/drug effects ; Oligodendroglia/metabolism ; Peripheral Nervous System/drug effects ; Peripheral Nervous System/physiology ; Recovery of Function/drug effects ; Remyelination/drug effects ; SOXE Transcription Factors/metabolism ; STAT3 Transcription Factor/metabolism ; Schwann Cells/drug effects ; Schwann Cells/metabolism ; Theophylline/pharmacology ; Trans-Activators/metabolism ; Transcriptional Activation/drug effects
Czasopismo naukowe
Tytuł :
Selective repression of the Drosophila cyclin B promoter by retinoblastoma and E2F proteins.
Autorzy :
Mouawad R; Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States of America. Electronic address: .
Himadewi P; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States of America.
Kadiyala D; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States of America.
Arnosti DN; Graduate Program in Cell and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States of America; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2020 Jul; Vol. 1863 (7), pp. 194549. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Promoter Regions, Genetic*
Transcriptional Activation*
Cyclin B/*genetics
Drosophila Proteins/*genetics
Animals ; Cell Line ; Conserved Sequence ; Cyclin B/chemistry ; Cyclin B/metabolism ; Drosophila Proteins/chemistry ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Introns ; Protein Binding ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Central nervous system neuroblastic tumor with FOXR2 activation presenting both neuronal and glial differentiation: a case report.
Autorzy :
Furuta T; Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan. .
Moritsubo M; Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Muta H; Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Koga M; Department of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Komaki S; Department of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Nakamura H; Department of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Morioka M; Department of Neurosurgery, Kurume University School of Medicine, Kurume, Japan.
Ohshima K; Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.
Sugita Y; Department of Neuropathology, St. Mary's Hospital, Kurume, Japan.
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Źródło :
Brain tumor pathology [Brain Tumor Pathol] 2020 Jul; Vol. 37 (3), pp. 100-104. Date of Electronic Publication: 2020 Jun 13.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Transcriptional Activation*
Brain Neoplasms/*genetics
Brain Neoplasms/*pathology
Forkhead Transcription Factors/*genetics
Neuroblastoma/*genetics
Neuroblastoma/*pathology
Neuroglia/*pathology
Neurons/*pathology
Brain Neoplasms/diagnostic imaging ; Child, Preschool ; Female ; Humans ; Magnetic Resonance Imaging ; Neuroblastoma/diagnostic imaging ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Transcriptional regulation by the KMT2 histone H3K4 methyltransferases.
Autorzy :
Park K; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
Kim JA; Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, South Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon 34113, South Korea. Electronic address: .
Kim J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2020 Jul; Vol. 1863 (7), pp. 194545. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Transcriptional Activation*
Histone-Lysine N-Methyltransferase/*metabolism
Animals ; Histone-Lysine N-Methyltransferase/chemistry ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Liver Diseases/genetics ; Neoplasms/genetics ; Nervous System Diseases/genetics
Czasopismo naukowe
Tytuł :
EHF promotes colorectal carcinoma progression by activating TGF-β1 transcription and canonical TGF-β signaling.
Autorzy :
Wang L; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Ai M; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Nie M; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Zhao L; Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Deng G; Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hu S; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Han Y; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Zeng W; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Wang Y; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Yang M; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Wang S; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
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Źródło :
Cancer science [Cancer Sci] 2020 Jul; Vol. 111 (7), pp. 2310-2324. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Transcriptional Activation*
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*metabolism
Transcription Factors/*metabolism
Transforming Growth Factor beta1/*genetics
Transforming Growth Factor beta1/*metabolism
Adult ; Aged ; Animals ; Biomarkers, Tumor ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Disease Models, Animal ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Heterografts ; Humans ; Immunohistochemistry ; Male ; Mice ; Middle Aged ; Models, Biological ; Neoplasm Metastasis ; Neoplasm Staging ; Protein Transport ; Transcription Factors/genetics ; Tumor Burden
Czasopismo naukowe
Tytuł :
Yin Yang 1 Is Essential for Transcriptional Activation of the Bovine Sirt2 Gene in Preadipocytes.
Autorzy :
Li A; College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China.
Zhang Y; College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China.; Dairy Cattle Research Center, Shandong Academy of Agricultural Sciences, Jinan, P.R. China.
Wang H; College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China.
Mei C; College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China.; National Beef Cattle Improvement Center, Northwest A&F University, Yangling, P.R. China.
Li Y; College of Animal Science, South China Agricultural University, Guangzhou, P.R. China.
Zan L; College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China.; National Beef Cattle Improvement Center, Northwest A&F University, Yangling, P.R. China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2020 Jul; Vol. 39 (7), pp. 1119-1126. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptional Activation*
Adipocytes/*metabolism
Sirtuin 2/*genetics
YY1 Transcription Factor/*metabolism
3T3-L1 Cells ; Amino Acid Sequence ; Animals ; Base Sequence ; Cattle ; Humans ; Mice ; Promoter Regions, Genetic/genetics ; YY1 Transcription Factor/chemistry
Czasopismo naukowe
Tytuł :
MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation.
Autorzy :
Rogers JM; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Guo B; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Egan ED; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Aster JC; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Adelman K; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA .; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2020 May 14; Vol. 40 (11). Date of Electronic Publication: 2020 May 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
DNA-Binding Proteins/*metabolism
Receptors, Notch/*metabolism
Transcription Factors/*metabolism
Acetylation ; DNA-Binding Proteins/chemistry ; Histones/metabolism ; Humans ; Jurkat Cells ; Signal Transduction ; Transcription Factors/chemistry
Czasopismo naukowe
Tytuł :
Repeat induces not only gene silencing, but also gene activation in mammalian cells.
Autorzy :
Ogaki Y; Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
Fukuma M; Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
Shimizu N; Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
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Źródło :
PloS one [PLoS One] 2020 Jun 24; Vol. 15 (6), pp. e0235127. Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Transcriptional Activation*
Genome, Human/*genetics
Matrix Attachment Regions/*genetics
Replication Origin/*genetics
Animals ; Base Sequence ; CHO Cells ; Cell Line, Tumor ; Cricetinae ; Cricetulus ; Gene Expression Regulation ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; In Situ Hybridization, Fluorescence/methods ; Plasmids/genetics ; Repetitive Sequences, Nucleic Acid/genetics ; Retroelements/genetics
Czasopismo naukowe
Tytuł :
DLX2 activates Wnt1 transcription and mediates Wnt/β-catenin signal to promote osteogenic differentiation of hBMSCs.
Autorzy :
Zeng X; Guizhou Medical University, Guiyang 550004, PR China.
Wang Y; Department of Prosthodontics, The Affiliated Stomatology Hospital of Guizhou Medical University, Guiyang 550004, PR China.
Dong Q; Department of Prosthodontics, The Affiliated Stomatology Hospital of Guizhou Medical University, Guiyang 550004, PR China.
Ma MX; Department of Prosthodontics, The Affiliated Stomatology Hospital of Guizhou Medical University, Guiyang 550004, PR China.
Liu XD; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, PR China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Jun 20; Vol. 744, pp. 144564. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Osteogenesis*/genetics
Transcriptional Activation*
Wnt Signaling Pathway*
Homeodomain Proteins/*metabolism
Mesenchymal Stem Cells/*metabolism
Transcription Factors/*metabolism
Wnt1 Protein/*metabolism
Cells, Cultured ; Homeodomain Proteins/genetics ; Humans ; Mesenchymal Stem Cells/cytology ; Transcription Factors/genetics ; Wnt1 Protein/biosynthesis ; Wnt1 Protein/genetics
Czasopismo naukowe
Tytuł :
A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning.
Autorzy :
Erijman A; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kozlowski L; Quantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Sohrabi-Jahromi S; Quantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Fishburn J; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Warfield L; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Schreiber J; Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.
Noble WS; Department of Genome Sciences, University of Washington, Seattle, WA, USA; Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA.
Söding J; Quantitative and Computational Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. Electronic address: .
Hahn S; Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jun 04; Vol. 78 (5), pp. 890-902.e6. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays/*methods
Transcription Factors/*genetics
Transcriptional Activation/*genetics
Amino Acid Sequence/genetics ; Basic-Leucine Zipper Transcription Factors/genetics ; DNA-Binding Proteins/metabolism ; Deep Learning ; Protein Binding ; Protein Domains/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; Transcriptional Activation/physiology
Czasopismo naukowe
Tytuł :
Transcriptional activation during cell reprogramming correlates with the formation of 3D open chromatin hubs.
Autorzy :
Di Stefano M; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028, Barcelona, Spain. .; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain. .
Stadhouders R; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain.; Department of Pulmonary Medicine and Department of Cell Biology, Erasmus MC, Rotterdam, the Netherlands.
Farabella I; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain.
Castillo D; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain.
Serra F; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028, Barcelona, Spain.; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain.; Computational Biology Group-Barcelona Supercomputing Center (BSC), 08034, Barcelona, Spain.
Graf T; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain. .
Marti-Renom MA; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028, Barcelona, Spain. .; Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003, Barcelona, Spain. .; Universitat Pompeu Fabra (UPF), 08002, Barcelona, Spain. .; ICREA, Pg. Lluís Companys 23, 08010, Barcelona, Spain. .
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Źródło :
Nature communications [Nat Commun] 2020 May 22; Vol. 11 (1), pp. 2564. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Transcriptional Activation*
B-Lymphocytes/*metabolism
Chromatin/*chemistry
Animals ; B-Lymphocytes/chemistry ; B-Lymphocytes/cytology ; Cell Nucleus/chemistry ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Mice ; Pluripotent Stem Cells/chemistry ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism
Czasopismo naukowe
Tytuł :
Release of promoter-proximal paused Pol II in response to histone deacetylase inhibition.
Autorzy :
Vaid R; Dept. Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.
Wen J; Dept. Genome Sciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia.
Mannervik M; Dept. Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 May 21; Vol. 48 (9), pp. 4877-4890.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Promoter Regions, Genetic*
Transcriptional Activation*/drug effects
Histone Deacetylase Inhibitors/*pharmacology
Histones/*metabolism
RNA Polymerase II/*metabolism
Acetylation ; Animals ; Cell Line ; Chromatin/metabolism ; Drosophila ; HEK293 Cells ; Humans ; Transcription Elongation, Genetic ; Transcription, Genetic/drug effects
Czasopismo naukowe

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