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Wyszukujesz frazę ""Transcriptional Regulator ERG"" wg kryterium: Temat


Tytuł :
EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
Autorzy :
Zoma M; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Curti L; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Center for Genomic Science of , Fondazione Istituto Italiano di Tecnologia (IIT), Milan, Italy.
Shinde D; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Albino D; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Mitra A; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Sgrignani J; Università della Svizzera Italiana (USI), Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland.
Mapelli SN; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Sandrini G; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
Civenni G; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Merulla J; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Chiorino G; Laboratory of Cancer Genomics, Fondazione Edo ed Elvo Tempia Valenta, Biella, Italy.
Kunderfranco P; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.; Humanitas Research Center, Milan, Italy.
Cacciatore A; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Kokanovic A; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Rinaldi A; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Cavalli A; Università della Svizzera Italiana (USI), Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland.
Catapano CV; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland.
Carbone GM; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), Bellinzona, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 06; Vol. 12 (1), pp. 4147. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer of Zeste Homolog 2 Protein/*metabolism
Lysine/*metabolism
Oncogene Proteins/*metabolism
Oncogene Proteins, Fusion/*metabolism
Prostatic Neoplasms/*metabolism
Serine Endopeptidases/*metabolism
Transcriptional Regulator ERG/*metabolism
Adenocarcinoma/genetics ; Animals ; Enhancer of Zeste Homolog 2 Protein/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Male ; Mice ; Mice, Knockout ; Oncogene Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Prostatic Neoplasms/genetics ; Protein Conformation ; Protein Processing, Post-Translational ; Sequence Alignment ; Serine Endopeptidases/genetics ; Trans-Activators/metabolism ; Transcription Factors/genetics ; Transcriptional Regulator ERG/genetics
Czasopismo naukowe
Tytuł :
DNA Promoter Methylation and ERG Regulate the Expression of CD24 in Prostate Cancer.
Autorzy :
Tolkach Y; Institute of Pathology, Center for Integrated Oncology, University of Bonn, Bonn, Germany; Center for Integrated Oncology Aachen/Bonn/Cologne/Dusseldorf, Bonn, Germany.
Zarbl R; Center for Integrated Oncology Aachen/Bonn/Cologne/Dusseldorf, Bonn, Germany; Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
Bauer S; Division of Cancer Genome Research, German Cancer Research Center, German Cancer Consortium, and National Center for Tumor Diseases, Im Neuenheimer Feld 460, Heidelberg, Germany; Medical Faculty, Heidelberg University, Heidelberg, Germany.
Ritter M; Center for Integrated Oncology Aachen/Bonn/Cologne/Dusseldorf, Bonn, Germany; Department of Urology, University Hospital Bonn, Bonn, Germany.
Ellinger J; Center for Integrated Oncology Aachen/Bonn/Cologne/Dusseldorf, Bonn, Germany; Department of Urology, University Hospital Bonn, Bonn, Germany.
Hauser S; Department of Urology, University Hospital Bonn, Bonn, Germany.
Hüser L; Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim, Germany.
Klauck SM; Division of Cancer Genome Research, German Cancer Research Center, German Cancer Consortium, and National Center for Tumor Diseases, Im Neuenheimer Feld 460, Heidelberg, Germany.
Altevogt P; Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim, Germany.
Sültmann H; Division of Cancer Genome Research, German Cancer Research Center, German Cancer Consortium, and National Center for Tumor Diseases, Im Neuenheimer Feld 460, Heidelberg, Germany.
Dietrich D; Institute of Pathology, Center for Integrated Oncology, University of Bonn, Bonn, Germany; Center for Integrated Oncology Aachen/Bonn/Cologne/Dusseldorf, Bonn, Germany; Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany.
Kristiansen G; Institute of Pathology, Center for Integrated Oncology, University of Bonn, Bonn, Germany; Center for Integrated Oncology Aachen/Bonn/Cologne/Dusseldorf, Bonn, Germany. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Apr; Vol. 191 (4), pp. 618-630. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
CD24 Antigen/*metabolism
DNA/*metabolism
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*metabolism
Prostatic Neoplasms/*pathology
Transcriptional Regulator ERG/*metabolism
Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; DNA Methylation/physiology ; Humans ; Male ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Trans-Activators/genetics ; Transcriptional Regulator ERG/genetics
Czasopismo naukowe
Tytuł :
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
Autorzy :
Bernasocchi T; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
El Tekle G; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
Bolis M; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Mutti A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Vallerga A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Brandt LP; Department of Biomedical Research, University of Bern, 3008, Bern, Switzerland.
Spriano F; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
Svinkina T; The Broad Institute of MIT & Harvard, Cambridge, MA, 02142, USA.
Zoma M; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.; University of Lausanne, 1011, Lausanne, VD, Switzerland.
Ceserani V; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Rinaldi A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Janouskova H; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Bossi D; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Cavalli M; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Mosole S; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Geiger R; Institute for Research in Biomedicine, 6500, Bellinzona, TI, Switzerland.
Dong Z; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Yang CG; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Albino D; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Rinaldi A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Schraml P; Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, ZH, Switzerland.
Linder S; The Netherlands Cancer Institute, Oncode Institute, 1066 CX, Amsterdam, The Netherlands.
Carbone GM; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Alimonti A; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Bertoni F; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland.
Moch H; Department of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Zurich, ZH, Switzerland.
Carr SA; The Broad Institute of MIT & Harvard, Cambridge, MA, 02142, USA.
Zwart W; The Netherlands Cancer Institute, Oncode Institute, 1066 CX, Amsterdam, The Netherlands.
Kruithof-de Julio M; Department of Biomedical Research, Urology Research Laboratory, University of Bern, 3010, Bern, Switzerland.; Department of Urology, Inselspital, Bern, Switzerland.
Rubin MA; Department of Biomedical Research, University of Bern, 3008, Bern, Switzerland.
Udeshi ND; The Broad Institute of MIT & Harvard, Cambridge, MA, 02142, USA.
Theurillat JP; Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italiana, 6500, Bellinzona, TI, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 02; Vol. 12 (1), pp. 734. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Proteins/*metabolism
Oncogene Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Repressor Proteins/*metabolism
Transcriptional Regulator ERG/*metabolism
Ubiquitin-Protein Ligase Complexes/*metabolism
Animals ; Biomarkers, Tumor/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Co-Repressor Proteins/genetics ; Co-Repressor Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; HEK293 Cells ; Humans ; Immunohistochemistry ; Immunoprecipitation ; Male ; Mice ; Mice, Nude ; Mutation/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins/genetics ; Prostatic Neoplasms/genetics ; Protein Binding ; Proteomics ; Receptors, Androgen/metabolism ; Repressor Proteins/genetics ; Signal Transduction/physiology ; Transcriptional Regulator ERG/genetics ; Ubiquitin-Protein Ligase Complexes/genetics
Czasopismo naukowe
Tytuł :
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming.
Autorzy :
Li F; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Yuan Q; Center for Excellence in Mathematical Sciences (CEMS), National Center for Mathematics and Interdisciplinary Sciences (NCMIS), Key Laboratory of Management, Decision and Information Systems (MDIS)., Academy of Mathematics and Systems Science, National Center for Mathematics and Interdisciplinary Sciences, and.; School of Mathematical Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China.
Di W; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Xia X; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Liu Z; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Mao N; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Li L; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Li C; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
He J; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Li Y; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Guo W; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang X; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhu Y; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Aji R; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang S; Department of Urology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Tong X; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Ji H; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Chi P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine and.; Department of Cell and Developmental Biology, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York, USA.
Carver B; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Division of Urology, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Wang Y; Center for Excellence in Mathematical Sciences (CEMS), National Center for Mathematics and Interdisciplinary Sciences (NCMIS), Key Laboratory of Management, Decision and Information Systems (MDIS)., Academy of Mathematics and Systems Science, National Center for Mathematics and Interdisciplinary Sciences, and.; School of Mathematical Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China.; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.; Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
Chen Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Department of Medicine and.; Department of Cell and Developmental Biology, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York, USA.
Gao D; State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Nov 02; Vol. 130 (11), pp. 5924-5941.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Epithelial Cells/*metabolism
Oncogene Proteins/*metabolism
Prostatic Neoplasms/*metabolism
Transcriptional Regulator ERG/*metabolism
Animals ; Epithelial Cells/pathology ; Gene Knockout Techniques ; Male ; Mice ; Mice, Transgenic ; Oncogene Proteins/genetics ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Transcriptional Regulator ERG/genetics
Czasopismo naukowe
Tytuł :
Transcriptional network involving ERG and AR orchestrates Distal-less homeobox-1 mediated prostate cancer progression.
Autorzy :
Goel S; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Bhatia V; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Kundu S; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Biswas T; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India.
Carskadon S; Vattikuti Urology Institute, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
Gupta N; Department of Pathology, Henry Ford Health System, Detroit, MI, USA.
Asim M; Department of Clinical and Experimental Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Morrissey C; Department of Urology, University of Washington, Seattle, WA, USA.
Palanisamy N; Vattikuti Urology Institute, Department of Urology, Henry Ford Health System, Detroit, MI, USA.
Ateeq B; Molecular Oncology Laboratory, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., India. .; The Mehta Family Center for Engineering in Medicine, Indian Institute of Technology Kanpur, Kanpur, U.P., India. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 07; Vol. 12 (1), pp. 5325. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcription, Genetic*
Homeodomain Proteins/*genetics
Prostatic Neoplasms/*genetics
Receptors, Androgen/*genetics
Transcription Factors/*genetics
Androgen Antagonists/pharmacology ; Animals ; Azepines/pharmacology ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, SCID ; Neoplasm Metastasis ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Promoter Regions, Genetic ; Prostate/drug effects ; Prostate/metabolism ; Prostate/pathology ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Protein Binding ; Receptors, Androgen/metabolism ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Signal Transduction ; Survival Analysis ; Transcription Factors/metabolism ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism ; Triazoles/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Why do pre-clinical medical students learn ultrasound? Exploring learning motivation through ERG theory.
Autorzy :
Wang TC; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Emergency Department, Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, No.111, Sec. 3, Xinglong Rd, Taipei, 11696, Taiwan.
Chen WT; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Emergency Department, Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, No.111, Sec. 3, Xinglong Rd, Taipei, 11696, Taiwan.
Kang YN; Department of Education and Humanities in Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Education, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Lin CW; Department of Education and Humanities in Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Education, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Center for Education in Medical Simulation, Taipei Medical University, Taipei, Taiwan.
Cheng CY; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Internal Medicine, Division of Nephrology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Suk FM; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Internal Medicine, Division of Gastroenterology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chen HY; Center for Education in Medical Simulation, Taipei Medical University, Taipei, Taiwan.
Hsu CW; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Emergency Department, Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, No.111, Sec. 3, Xinglong Rd, Taipei, 11696, Taiwan.
Fong TH; Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Huang WC; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. .; Emergency Department, Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, No.111, Sec. 3, Xinglong Rd, Taipei, 11696, Taiwan. .; Department of Education and Humanities in Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. .; Department of Education, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. .; Center for Education in Medical Simulation, Taipei Medical University, Taipei, Taiwan. .
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Źródło :
BMC medical education [BMC Med Educ] 2021 Aug 19; Vol. 21 (1), pp. 438. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Motivation*
Students, Medical*
Humans ; Learning ; Personal Autonomy ; Transcriptional Regulator ERG ; Ultrasonography
Czasopismo naukowe
Tytuł :
ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development.
Autorzy :
Harada Y; Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.; Laboratory of Stem Cell & Regenerative Medicine, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan.
Tanaka T; Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Arai Y; Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.; Laboratory of Animal Experiment and Medical Management, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Isomoto Y; Laboratory of Animal Experiment and Medical Management, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Nakano A; Laboratory of Animal Experiment and Medical Management, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Nakao S; Laboratory of Stem Cell & Regenerative Medicine, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan.
Urasaki A; Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Watanabe Y; Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Kawamura T; Laboratory of Stem Cell & Regenerative Medicine, Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, Kusatsu, Japan.
Nakagawa O; Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
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Źródło :
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2021 Aug; Vol. 26 (8), pp. 611-626. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Enhancer Elements, Genetic*
Endothelium, Vascular/*metabolism
Immediate-Early Proteins/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Animals ; Chromatin/metabolism ; DNA-Directed RNA Polymerases/metabolism ; Endothelial Cells/metabolism ; Endothelium, Vascular/embryology ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Immediate-Early Proteins/genetics ; Mice ; Oncogene Proteins/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Proto-Oncogene Protein c-ets-1/metabolism ; Proto-Oncogene Protein c-fli-1/metabolism ; Transcription Initiation Site ; Transcriptional Regulator ERG/metabolism
Czasopismo naukowe
Tytuł :
The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents.
Autorzy :
Kim T; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Morshed MN; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.; Center for Advanced Research in Sciences (CARS), University of Dhaka, Dhaka, Bangladesh.
Londhe AM; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Lim JW; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Lee HE; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Cho S; Department of Food Science and Technology, Pukyong National University, Pusan, Republic of Korea.
Cho SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Republic of Korea.
Hwang H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Republic of Korea.
Lim SM; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.
Lee JY; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Lee J; Department of Global Medical Science, Sungshin University, Seoul, Republic of Korea.
Pae AN; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 831-846.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Mitochondria/*drug effects
Neuroprotective Agents/*pharmacology
Protein Aggregation, Pathological/*drug therapy
Small Molecule Libraries/*pharmacology
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Cell Survival/drug effects ; Cells, Cultured ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Humans ; Ligands ; Mice ; Mitochondria/metabolism ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Protein Aggregation, Pathological/metabolism ; Protein Aggregation, Pathological/pathology ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Transcriptional Regulator ERG/antagonists & inhibitors ; Transcriptional Regulator ERG/metabolism
Czasopismo naukowe
Tytuł :
ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion.
Autorzy :
Saulnier O; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.; Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France.
Guedri-Idjouadiene K; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
Aynaud MM; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Chakraborty A; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1278, F-91405 Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1278, F-91405 Orsay, France.; Équipe Labellisée Ligue Nationale Contre le Cancer, F-91405 Orsay, France.
Bruyr J; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
Pineau J; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
O'Grady T; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
Mirabeau O; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Grossetête S; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Galvan B; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
Claes M; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
Al Oula Hassoun Z; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
Sadacca B; INSERM U932, RT2Lab Team, Translational Research Department, PSL Research University, Institut Curie, F-75005 Paris, France.; CNRS UMR5219, Institut de Mathématiques de Toulouse; Université de Toulouse; F-31062 Toulouse, France.
Laud K; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Zaïdi S; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Surdez D; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Baulande S; Institut Curie, PSL Research University, NGS Platform, 26 rue d'Ulm, F-75005 Paris, France.
Rambout X; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
Tirode F; Claude Bernard University Lyon 1, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon (CRCL), Lyon University, Lyon, France.
Dutertre M; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1278, F-91405 Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1278, F-91405 Orsay, France.; Équipe Labellisée Ligue Nationale Contre le Cancer, F-91405 Orsay, France.
Delattre O; INSERM U830, Équipe Labellisée LNCC, PSL Research University, SIREDO Oncology Centre, Institut Curie, 75005 Paris, France.
Dequiedt F; University of Liège, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Liège, Belgium.; University of Liège, GIGA-Molecular Biology of Diseases, Liège, Belgium.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 May 21; Vol. 49 (9), pp. 5038-5056.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Oncogene Proteins, Fusion/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
RNA Splicing Factors/*metabolism
RNA-Binding Protein EWS/*metabolism
Repressor Proteins/*metabolism
Calmodulin-Binding Proteins/genetics ; Calmodulin-Binding Proteins/metabolism ; Cell Line ; Cell Line, Tumor ; HeLa Cells ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Protein Domains ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/metabolism ; Transcriptional Regulator ERG/chemistry ; Transcriptional Regulator ERG/metabolism
Czasopismo naukowe
Tytuł :
An Erg-driven transcriptional program controls B cell lymphopoiesis.
Autorzy :
Ng AP; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. .; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia. .
Coughlan HD; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Hediyeh-Zadeh S; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Behrens K; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Johanson TM; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Low MSY; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Monash Haematology, Monash Hospital, Clayton, VIC, 3004, Australia.
Bell CC; Peter MacCallum Cancer Centre, Parkville, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Gilan O; Peter MacCallum Cancer Centre, Parkville, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Chan YC; Peter MacCallum Cancer Centre, Parkville, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Kueh AJ; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Boudier T; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Feltham R; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3010, Australia.
Gabrielyan A; Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3010, Australia.
DiRago L; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Hyland CD; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Ierino H; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Mifsud S; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Viney E; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Willson T; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Dawson MA; Peter MacCallum Cancer Centre, Parkville, VIC, 3000, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Centre for Cancer Research, The University of Melbourne, Parkville, VIC, 3010, Australia.
Allan RS; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Herold MJ; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Rogers K; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Advanced Technology and Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Tarlinton DM; Department of Immunology and Pathology, Monash University, Melbourne, VIC, 3004, Australia.
Smyth GK; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Davis MJ; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Nutt SL; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.; Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
Alexander WS; Blood Cells and Blood Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
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Źródło :
Nature communications [Nat Commun] 2020 Jun 15; Vol. 11 (1), pp. 3013. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
B-Lymphocytes/*metabolism
Cell Differentiation/*genetics
Hematopoietic Stem Cells/*metabolism
Lymphopoiesis/*genetics
Oncogene Proteins/*genetics
Transcriptional Regulator ERG/*genetics
Animals ; B-Lymphocytes/cytology ; Cell Lineage/genetics ; Cells, Cultured ; Gene Regulatory Networks/genetics ; Hematopoietic Stem Cells/cytology ; Mice, Inbred C57BL ; Mice, Knockout ; Oncogene Proteins/metabolism ; PAX5 Transcription Factor/genetics ; PAX5 Transcription Factor/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcriptional Regulator ERG/metabolism ; V(D)J Recombination/genetics
Czasopismo naukowe
Tytuł :
Xeroderma Pigmentosum group D suppresses proliferation and promotes apoptosis of HepG2 cells by downregulating ERG expression via the PPARγ pathway.
Autorzy :
He Y; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Tao W; Department of ICU, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Shang C; Administration Center, Jiangxi Electric Power Research Institute, Nanchang, China.
Qi C; Department of emergency, The First hospital of Nanchang city, Nanchang, China.
Ji D; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Lu W; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Chen G; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
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Źródło :
International journal of experimental pathology [Int J Exp Pathol] 2021 Jun; Vol. 102 (3), pp. 157-162. Date of Electronic Publication: 2021 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
PPAR gamma/*metabolism
Xeroderma Pigmentosum Group D Protein/*metabolism
Apoptosis/physiology ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation/physiology ; Down-Regulation ; Hep G2 Cells ; Humans ; Liver Neoplasms/metabolism ; Signal Transduction/physiology ; Transcriptional Regulator ERG/metabolism
Czasopismo naukowe
Tytuł :
Long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency and progressive retinopathy: one case report followed by ERGs, VEPs, EOG over a 17-year period.
Autorzy :
Rigaudière F; Service de Physiologie Clinique, Exploration Fonctionnelle, Hôpital Lariboisière, AP-HP, Paris, France. .; Faculté de Médecine Paris-Diderot, Université de Paris, Paris, France. .
Delouvrier E; Service d'Ophtalmologie, Hôpital Robert Debré, AP-HP, Paris, France.
Le Gargasson JF; Service de Physiologie Clinique, Exploration Fonctionnelle, Hôpital Lariboisière, AP-HP, Paris, France.; Faculté de Médecine Paris-Diderot, Université de Paris, Paris, France.
Milani P; Service de Physiologie Clinique, Exploration Fonctionnelle, Hôpital Lariboisière, AP-HP, Paris, France.
Ogier de Baulny H; Faculté de Médecine Paris-Diderot, Université de Paris, Paris, France.; Reference Center for Inborn Errors of Metabolism, Robert Debré Hospital, AP-HP, Paris, France.
Schiff M; Reference Center for Inborn Errors of Metabolism, Robert Debré Hospital, AP-HP, Paris, France.; Reference Center for Inborn Errors of Metabolism, Faculté de Médecine Paris-Descartes, Necker University Hospital, AP-HP, Université de Paris, Paris, France.; Institut Imagine, Inserm UMRS_1163, Paris, France.
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Źródło :
Documenta ophthalmologica. Advances in ophthalmology [Doc Ophthalmol] 2021 Jun; Vol. 142 (3), pp. 371-380. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Cardiomyopathies*
Retinal Diseases*/diagnosis
Rhabdomyolysis*
3-Hydroxyacyl CoA Dehydrogenases/genetics ; 3-Hydroxyacyl-CoA Dehydrogenase ; Adult ; Electrooculography ; Electroretinography ; Female ; Humans ; Infant ; Lipid Metabolism, Inborn Errors ; Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase ; Mitochondrial Myopathies ; Mitochondrial Trifunctional Protein/deficiency ; Nervous System Diseases ; Transcriptional Regulator ERG ; Young Adult
SCR Disease Name :
Trifunctional Protein Deficiency With Myopathy And Neuropathy
Czasopismo naukowe
Tytuł :
[Decreased visual acuity as presenting sign of a late case of congenital stationary night blindness: The role of ERG].
Autorzy :
Memmi B; Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, université Paris Est-Créteil, 40, avenue de Verdun, 94000 Créteil, France. Electronic address: .
Miere A; Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, université Paris Est-Créteil, 40, avenue de Verdun, 94000 Créteil, France.
Zambrowski O; Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, université Paris Est-Créteil, 40, avenue de Verdun, 94000 Créteil, France.
Souied EH; Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, université Paris Est-Créteil, 40, avenue de Verdun, 94000 Créteil, France.
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Transliterated Title :
Acuité visuelle diminuée révélant un cas tardif de cécité nocturne stationnaire congénitale : intérêt de l’ERG.
Źródło :
Journal francais d'ophtalmologie [J Fr Ophtalmol] 2021 Jun; Vol. 44 (6), pp. e365-e368. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Letter
MeSH Terms :
Eye Diseases, Hereditary*/diagnosis
Genetic Diseases, X-Linked*
Night Blindness*/diagnosis
Electroretinography ; Humans ; Myopia ; Transcriptional Regulator ERG ; Visual Acuity
SCR Disease Name :
Night blindness, congenital stationary
Opinia redakcyjna
Tytuł :
Expression and ERG regulation of PIM kinases in prostate cancer.
Autorzy :
Eerola SK; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland.
Kohvakka A; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland.
Tammela TLJ; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland.; Department of Urology, Tampere University Hospital, Tampere, Finland.
Koskinen PJ; Department of Biology, University of Turku, Turku, Finland.
Latonen L; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Visakorpi T; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland.; Fimlab Laboratories Ltd, Tampere University Hospital, Tampere, Finland.
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Źródło :
Cancer medicine [Cancer Med] 2021 May; Vol. 10 (10), pp. 3427-3436. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Prostatic Neoplasms/*genetics
Proto-Oncogene Proteins c-pim-1/*genetics
Aged ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; Middle Aged ; Prostate/pathology ; Prostatic Hyperplasia/genetics ; Prostatic Hyperplasia/pathology ; Prostatic Neoplasms/pathology ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Transcriptional Regulator ERG/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.
Autorzy :
Mao N; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Gao D; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Hu W; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Gadal S; Molecular Oncology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Hieronymus H; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Wang S; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Lee YS; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Sullivan P; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Zhang Z; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Choi D; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Rosen N; Molecular Oncology Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Sawyers CL; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Gopalan A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Chen Y; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Carver BS; Human Oncogenesis and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. .; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.; Division of Urology, Memorial Sloan Kettering Cancer Center, New York, New York.
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Źródło :
Cancer research [Cancer Res] 2020 Apr 01; Vol. 80 (7), pp. 1428-1437. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Receptor Substrate Proteins/*genetics
Oncogene Proteins/*metabolism
Prostatic Neoplasms/*genetics
Transcriptional Regulator ERG/*metabolism
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; DNA Copy Number Variations ; Disease Models, Animal ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Gene Knockout Techniques ; Gene Rearrangement ; Humans ; Insulin Receptor Substrate Proteins/metabolism ; Male ; Mice ; Oncogene Proteins/genetics ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Primary Cell Culture ; Promoter Regions, Genetic/genetics ; Prostate/pathology ; Prostatic Neoplasms/pathology ; RNA-Seq ; Signal Transduction/genetics ; Transcriptional Regulator ERG/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
An ERG Gene Analysis in Two Cases with Metastatic Castration-resistant Prostate Cancer in Which Abiraterone Demonstrated Long-term Efficacy.
Autorzy :
Yoshizawa T; Department of Urology, Nihon University School of Medicine, Japan.
Yamaguchi K; Department of Urology, Nihon University School of Medicine, Japan.
Kawata N; Department of Urology, Nihon University Hospital, Japan.
Ryuzaki H; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University Hospital, Japan.
Ogawa M; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University Hospital, Japan.
Obinata D; Department of Urology, Nihon University School of Medicine, Japan.
Mochida J; Department of Urology, Nihon University School of Medicine, Japan.
Takahashi S; Department of Urology, Nihon University School of Medicine, Japan.
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Źródło :
Internal medicine (Tokyo, Japan) [Intern Med] 2020 Feb 01; Vol. 59 (3), pp. 395-399. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Androstenes/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Neoplasm Metastasis/*drug therapy
Prednisolone/*therapeutic use
Prostatic Neoplasms, Castration-Resistant/*drug therapy
Transcriptional Regulator ERG/*drug effects
Aged ; Humans ; Male ; Middle Aged ; Transcriptional Regulator ERG/genetics ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The phosphorylation state of both hERG and KvLQT1 mediates protein-protein interactions between these complementary cardiac potassium channel alpha subunits.
Autorzy :
Popescu MC; Department of Biological Sciences and Biochemistry Program, Wellesley College, 106 Central St., Wellesley, MA 02481, United States of America.
Lee YJ; Department of Biological Sciences and Biochemistry Program, Wellesley College, 106 Central St., Wellesley, MA 02481, United States of America.
Kim SS; Department of Biological Sciences and Biochemistry Program, Wellesley College, 106 Central St., Wellesley, MA 02481, United States of America.
Wade HM; Department of Biological Sciences and Biochemistry Program, Wellesley College, 106 Central St., Wellesley, MA 02481, United States of America.
Papakyrikos AM; Department of Biological Sciences and Biochemistry Program, Wellesley College, 106 Central St., Wellesley, MA 02481, United States of America.
Darling LEO; Department of Biological Sciences and Biochemistry Program, Wellesley College, 106 Central St., Wellesley, MA 02481, United States of America. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2021 Apr 01; Vol. 1863 (4), pp. 183556. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arrhythmias, Cardiac/*metabolism
ERG1 Potassium Channel/*metabolism
KCNQ1 Potassium Channel/*metabolism
Arrhythmias, Cardiac/genetics ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; ERG1 Potassium Channel/genetics ; HEK293 Cells ; Humans ; KCNQ1 Potassium Channel/genetics ; Phosphorylation/genetics ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism
Czasopismo naukowe
Tytuł :
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate.
Autorzy :
Lu TM; Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065.; Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10065.
Houghton S; Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065.
Magdeldin T; Department of Neurology and the Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY 10065.
Durán JGB; Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065.
Minotti AP; Developmental Biology, the Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; The Biochemistry, Structural Biology, Cell Biology, Developmental Biology and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065.
Snead A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032.
Sproul A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032.
Nguyen DT; Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065.
Xiang J; Genomics Resources Core Facility, Weill Cornell Medicine, New York, NY 10065.
Fine HA; Department of Neurology and the Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY 10065.
Rosenwaks Z; Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10065.
Studer L; The Biochemistry, Structural Biology, Cell Biology, Developmental Biology and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065.
Rafii S; Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065.
Agalliu D; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032.; Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032.
Redmond D; Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065; .
Lis R; Ansary Stem Cell Institute, Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10065; .; Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10065.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 23; Vol. 118 (8).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*cytology
Pluripotent Stem Cells/*cytology
Transcription Factors/*genetics
Animals ; Blood-Brain Barrier ; Brain/blood supply ; Brain/cytology ; Cell Differentiation ; Cell Line ; Cellular Reprogramming/physiology ; Endothelium, Vascular/physiology ; Gene Expression ; Humans ; Mice, Inbred Strains ; Pluripotent Stem Cells/physiology ; Proto-Oncogene Protein c-fli-1/genetics ; Proto-Oncogene Protein c-fli-1/metabolism ; Single-Cell Analysis ; Transcription Factors/metabolism ; Transcriptional Regulator ERG/genetics ; Transcriptional Regulator ERG/metabolism
Czasopismo naukowe
Tytuł :
TMPRSS2-ERG fusion impacts anterior tumor location in men with prostate cancer.
Autorzy :
Yamoah K; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Lal P; The Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Awasthi S; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Naghavi AO; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Rounbehler RJ; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Gerke T; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Berglund AE; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Pow-Sang JM; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Schaeffer EM; Northwestern University, Evanston, Illinois, USA.
Dhillon J; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Park JY; H Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Rebbeck TR; Dana Farber Cancer Institute and Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
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Źródło :
The Prostate [Prostate] 2021 Feb; Vol. 81 (2), pp. 109-117. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
African Americans/*genetics
Oncogene Proteins, Fusion/*genetics
Prostate/*pathology
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*pathology
Cohort Studies ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prostatic Neoplasms/chemistry ; RNA, Messenger ; Transcriptional Regulator ERG/analysis ; Transcriptional Regulator ERG/genetics
Czasopismo naukowe
Tytuł :
Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome.
Autorzy :
Ishihara K; Department of Pathological Biochemistry, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
Shimizu R; Department of Pathological Biochemistry, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
Takata K; Department of Clinical and Translational Physiology, Division of Biological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.; Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Kawashita E; Department of Pathological Biochemistry, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
Amano K; Laboratory for Neurogenetics, RIKEN Center for Brain Science, Saitama, Japan.
Shimohata A; Laboratory for Neurogenetics, RIKEN Center for Brain Science, Saitama, Japan.
Low D; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Nabe T; Laboratory of Immunopharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan.
Sago H; Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Alexander WS; Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Australia.
Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yamakawa K; Laboratory for Neurogenetics, RIKEN Center for Brain Science, Saitama, Japan.
Akiba S; Department of Pathological Biochemistry, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan.
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Źródło :
Brain pathology (Zurich, Switzerland) [Brain Pathol] 2020 Jan; Vol. 30 (1), pp. 75-91. Date of Electronic Publication: 2019 Jul 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down Syndrome/*genetics
Neurogenesis/*genetics
Transcriptional Regulator ERG/*genetics
Animals ; Brain/metabolism ; Disease Models, Animal ; Down Syndrome/immunology ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurogenesis/immunology ; Oncogene Proteins/genetics ; Oncogene Proteins/metabolism ; Pregnancy ; Transcriptional Regulator ERG/metabolism ; Transcriptome
Czasopismo naukowe

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