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Wyszukujesz frazę ""Transforming Growth Factor beta"" wg kryterium: Temat


Tytuł :
Computational modeling of transforming growth factor β and activin a receptor complex formation in the context of promiscuous signaling regulation.
Autorzy :
Farmer SM; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
Andl CD; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Sep; Vol. 39 (14), pp. 5166-5181. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Activin Receptors, Type I*/metabolism
Transforming Growth Factor beta*
Activins ; Molecular Docking Simulation ; Receptors, Transforming Growth Factor beta ; Signal Transduction
Czasopismo naukowe
Tytuł :
Elucidating the cellular mechanism for E2-induced dermal fibrosis.
Autorzy :
Baker Frost D; Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, USA. .
Savchenko A; Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, USA.
Ogunleye A; Division of Plastic Surgery, University of North Carolina, Chapel Hill, USA.
Armstrong M; Department of Surgery, Division of Plastic Surgery, Medical University of South Carolina, Charleston, USA.
Feghali-Bostwick C; Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, USA.
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Źródło :
Arthritis research & therapy [Arthritis Res Ther] 2021 Feb 27; Vol. 23 (1), pp. 68. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Scleroderma, Systemic*/pathology
Transforming Growth Factor beta*
Cells, Cultured ; Fibroblasts/pathology ; Fibrosis ; Humans ; Receptors, Transforming Growth Factor beta ; Skin/pathology
Czasopismo naukowe
Tytuł :
Targeting transforming growth factor-β receptors in pulmonary hypertension.
Autorzy :
Guignabert C; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 (Pulmonary Hypertension: Pathophysiology and Novel Therapies), Hôpital Marie Lannelongue, Le Plessis-Robinson, France.
Humbert M; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; INSERM UMR_S 999 (Pulmonary Hypertension: Pathophysiology and Novel Therapies), Hôpital Marie Lannelongue, Le Plessis-Robinson, France.; Dept of Respiratory and Intensive Care Medicine, French Pulmonary Hypertension Reference Center, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin-Bicêtre, France.
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Źródło :
The European respiratory journal [Eur Respir J] 2021 Feb 04; Vol. 57 (2). Date of Electronic Publication: 2021 Feb 04 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hypertension, Pulmonary*
Receptors, Transforming Growth Factor beta*
Bone Morphogenetic Proteins ; Humans ; Transforming Growth Factor beta ; Transforming Growth Factors
Czasopismo naukowe
Tytuł :
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.
Autorzy :
Leach JDG; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Vlahov N; Cancer Research UK Beatson Institute, Glasgow, UK.
Tsantoulis P; Department of Medical Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Department of Oncology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK.
Flanagan DJ; Cancer Research UK Beatson Institute, Glasgow, UK.
Gilroy K; Cancer Research UK Beatson Institute, Glasgow, UK.
Sphyris N; Cancer Research UK Beatson Institute, Glasgow, UK.
Vázquez EG; Gastrointestinal Stem Cell Biology Lab, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Vincent DF; Cancer Research UK Beatson Institute, Glasgow, UK.
Faller WJ; Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hodder MC; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Raven A; Cancer Research UK Beatson Institute, Glasgow, UK.
Fey S; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Najumudeen AK; Cancer Research UK Beatson Institute, Glasgow, UK.
Strathdee D; Cancer Research UK Beatson Institute, Glasgow, UK.
Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK.
Hughes M; Cancer Research UK Beatson Institute, Glasgow, UK.
Clark W; Cancer Research UK Beatson Institute, Glasgow, UK.
Shaw R; Cancer Research UK Beatson Institute, Glasgow, UK.
van Hooff SR; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands.
Huels DJ; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands.
Medema JP; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands.
Barry ST; Bioscience, Early Oncology, AstraZeneca, Cambridge, UK.
Frame MC; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Unciti-Broceta A; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Leedham SJ; Gastrointestinal Stem Cell Biology Lab, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Inman GJ; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Jackstadt R; Cancer Research UK Beatson Institute, Glasgow, UK.
Thompson BJ; EMBL Australia, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Campbell AD; Cancer Research UK Beatson Institute, Glasgow, UK.
Tejpar S; Molecular Digestive Oncology, Department of Oncology, University of Leuven, Leuven, Belgium.
Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK. .; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. .
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Corporate Authors :
S:CORT consortium
Źródło :
Nature communications [Nat Commun] 2021 Jun 08; Vol. 12 (1), pp. 3464. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Carcinogenesis/*metabolism
Colonic Neoplasms/*metabolism
Proto-Oncogene Proteins B-raf/*metabolism
Receptors, Transforming Growth Factor beta/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Carcinogenesis/pathology ; Cell Differentiation ; Cell Survival ; Colon/pathology ; Colonic Neoplasms/genetics ; Epithelial Cells/metabolism ; Fetus/pathology ; Inflammation/pathology ; Kaplan-Meier Estimate ; MAP Kinase Signaling System ; Mice, Inbred C57BL ; Mutation ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology ; Transcription Factors/metabolism ; Transforming Growth Factor beta/metabolism ; Wnt Proteins/metabolism ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Epithelial-Mesenchymal Transition (EMT) Induced by TGF-β in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism.
Autorzy :
Soukupova J; TGF-β and Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell) Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Malfettone A; TGF-β and Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell) Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Bertran E; TGF-β and Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell) Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.; CIBER Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Hernández-Alvarez MI; CIBER Diabetes and Metabolic Associated Diseases (CIBERdem), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Biochemistry and Molecular Biomedicine Department, Universitat de Barcelona-UB, 08028 Barcelona, Spain.
Peñuelas-Haro I; TGF-β and Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell) Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.; CIBER Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Dituri F; National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013 Bari, Italy.
Giannelli G; National Institute of Gastroenterology, IRCCS 'S. De Bellis' Research Hospital, Castellana Grotte, 70013 Bari, Italy.
Zorzano A; CIBER Diabetes and Metabolic Associated Diseases (CIBERdem), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Biochemistry and Molecular Biomedicine Department, Universitat de Barcelona-UB, 08028 Barcelona, Spain.; Institute for Research in Biomedicina (IRB Barcelona), 08028 Barcelona, Spain.; Barcelona Institute of Science and Technology (BIST), 08036 Barcelona, Spain.
Fabregat I; TGF-β and Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell) Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain.; CIBER Hepatic and Digestive Diseases (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Physiological Sciences, School of Medicine and Health Sciences, Universitat de Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 24; Vol. 22 (11). Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Epithelial-Mesenchymal Transition/*drug effects
Lipid Metabolism/*drug effects
Liver Neoplasms/*metabolism
Metabolome/*drug effects
Transcriptome/*drug effects
Transforming Growth Factor beta/*pharmacology
Cell Movement/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Gene Silencing ; Hep G2 Cells ; Humans ; Metabolome/genetics ; Metabolomics ; Mitochondria/drug effects ; Mitochondria/metabolism ; Oxidative Phosphorylation/drug effects ; Receptors, Transforming Growth Factor beta/genetics ; Receptors, Transforming Growth Factor beta/metabolism ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
Autorzy :
Zehender A; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Li YN; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Lin NY; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.; Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Stefanica A; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Nüchel J; Center for Biochemistry, University of Cologne, Faculty of Medicine, Cologne, Germany.
Chen CW; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Hsu HH; Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Zhu H; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.; Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ding X; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Huang J; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Shen L; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Györfi AH; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Soare A; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Rauber S; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Bergmann C; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Ramming A; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Plomann M; Center for Biochemistry, University of Cologne, Faculty of Medicine, Cologne, Germany.
Eckes B; Translational Matrix Biology, University of Cologne, Faculty of Medicine, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
Schett G; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany.; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Distler JHW; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. .; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 20; Vol. 12 (1), pp. 4404. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Autophagy/*genetics
Histone Acetyltransferases/*metabolism
Scleroderma, Systemic/*pathology
Transforming Growth Factor beta/*metabolism
Adult ; Aged ; Animals ; Autophagy-Related Protein 7/genetics ; Autophagy-Related Protein 7/metabolism ; Biopsy ; Case-Control Studies ; Disease Models, Animal ; Down-Regulation ; Female ; Fibroblasts ; Fibrosis ; Gene Knockout Techniques ; Healthy Volunteers ; Humans ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; NIH 3T3 Cells ; Primary Cell Culture ; Receptors, Transforming Growth Factor beta ; Signal Transduction/genetics ; Skin/cytology ; Skin/pathology ; Smad3 Protein/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells.
Autorzy :
Tan Q; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Wang Q; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.; Radiation Oncology Center, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Kuang L; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Zhang J; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Peng X; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Liang S; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Liu M; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Chen H; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Chen S; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Luo X; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Qi H; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Li C; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Luo F; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Huang S; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Ni Z; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Jin M; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Su N; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Yang J; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Yang P; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Chen B; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Chen L; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Du X; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Xie Y; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Chen L; Department of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Jul; Vol. 236 (7), pp. 5278-5292. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cartilage, Articular/*metabolism
Cellular Senescence/*physiology
Osteoarthritis/*metabolism
Receptor, Transforming Growth Factor-beta Type I/*metabolism
Stem Cells/*metabolism
Animals ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/pathology ; Cartilage, Articular/pathology ; Mice ; Mice, Knockout ; Osteoarthritis/pathology ; Signal Transduction/physiology ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Abrogation of mesenchyme-specific TGF-β signaling results in lung malformation with prenatal pulmonary cysts in mice.
Autorzy :
Miao Q; Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.; Department of Allergy, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, People's Republic of China.
Chen H; Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.
Luo Y; Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.
Chiu J; Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.
Chu L; Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.
Thornton ME; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Grubbs BH; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Kolb M; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Lou J; Institute of Occupational Diseases, Hangzhou Medical College (Zhejiang Academy of Medical Science), Hangzhou, People's Republic of China.
Shi W; Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Jun 01; Vol. 320 (6), pp. L1158-L1168. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cysts/*metabolism
Lung Diseases/*pathology
Mesoderm/*cytology
Receptors, Transforming Growth Factor beta/*metabolism
Animals ; Cysts/pathology ; Epithelial Cells/metabolism ; Gene Expression Regulation, Developmental/genetics ; Lung/metabolism ; Lung/pathology ; Lung Diseases/metabolism ; Mice ; Mice, Transgenic ; Morphogenesis/drug effects ; Morphogenesis/physiology ; Organogenesis/physiology ; Protein-Serine-Threonine Kinases/metabolism ; Receptor, Transforming Growth Factor-beta Type II/metabolism
Czasopismo naukowe
Tytuł :
ALK1 regulates the internalization of endoglin and the type III TGF-β receptor.
Autorzy :
Tazat K; Department of Neurobiology, Tel Aviv University, Tel Aviv 6997801, Israel.
Pomeraniec-Abudy L; Department of Neurobiology, Tel Aviv University, Tel Aviv 6997801, Israel.
Hector-Greene M; Department of Medicine, Duke University Medical Center, Durham, NC 27708.
Szilágyi SS; Department of Neurobiology, Tel Aviv University, Tel Aviv 6997801, Israel.
Sharma S; Department of Neurobiology, Tel Aviv University, Tel Aviv 6997801, Israel.
Cai EM; Department of Medicine, Duke University Medical Center, Durham, NC 27708.
Corona AL; Department of Medicine, Duke University Medical Center, Durham, NC 27708.
Ehrlich M; Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Blobe GC; Department of Medicine, Duke University Medical Center, Durham, NC 27708.
Henis YI; Department of Neurobiology, Tel Aviv University, Tel Aviv 6997801, Israel.
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Źródło :
Molecular biology of the cell [Mol Biol Cell] 2021 Apr 01; Vol. 32 (7), pp. 605-621. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Activin Receptors, Type II/*metabolism
Endoglin/*metabolism
Proteoglycans/*metabolism
Receptors, Transforming Growth Factor beta/*metabolism
Activin Receptors, Type II/physiology ; Animals ; COS Cells ; Cell Line ; Chlorocebus aethiops ; Endocytosis ; Endoglin/physiology ; Endothelial Cells/metabolism ; Humans ; Phosphorylation ; Protein Binding ; Protein Transport ; Protein-Serine-Threonine Kinases/metabolism ; Proteoglycans/physiology ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; Receptors, Transforming Growth Factor beta/physiology ; Signal Transduction ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Recent progress in TGF-β inhibitors for cancer therapy.
Autorzy :
Huang CY; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, ROC; Department of Pathology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan, ROC.
Chung CL; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, ROC.
Hu TH; Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan, ROC.
Chen JJ; Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan, ROC; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
Liu PF; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC.
Chen CL; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, ROC; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Feb; Vol. 134, pp. 111046. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Neoplasms/*drug therapy
Transforming Growth Factor beta/*antagonists & inhibitors
Transforming Growth Factor beta/*metabolism
Animals ; Antibodies, Neutralizing/therapeutic use ; Aptamers, Peptide/therapeutic use ; Cancer Vaccines/therapeutic use ; Carcinogenesis/drug effects ; Clinical Trials as Topic ; Endocytosis/drug effects ; Fibrosis/drug therapy ; Humans ; Membrane Microdomains/metabolism ; Mice ; Oligonucleotides, Antisense/therapeutic use ; Receptors, Transforming Growth Factor beta/antagonists & inhibitors ; Receptors, Transforming Growth Factor beta/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Anti-TGFβ (Transforming Growth Factor β) Therapy With Betaglycan-Derived P144 Peptide Gene Delivery Prevents the Formation of Aortic Aneurysm in a Mouse Model of Marfan Syndrome.
Autorzy :
Arce C; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of Barcelona, Spain (C.A., I.R.-R., K.D.R., V.C., G.E.).
Rodríguez-Rovira I; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of Barcelona, Spain (C.A., I.R.-R., K.D.R., V.C., G.E.).
De Rycke K; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of Barcelona, Spain (C.A., I.R.-R., K.D.R., V.C., G.E.).
Durán K; Department of Cardiology, Hospital Clínic y Provincial de Barcelona, Spain (K.D.).
Campuzano V; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of Barcelona, Spain (C.A., I.R.-R., K.D.R., V.C., G.E.).; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Spain (V.C.).
Fabregat I; Bellvitge Biomedical Research Institute (IDIBELL) and Centro de Investigación Biomédica en Red de Enfermedades Hepático-Digestivas (CIBEREHD), ISCIII, Spain (I.F.).
Jiménez-Altayó F; Department of Therapeutic Pharmacology and Toxicology, School of Medicine, Neuroscience Institute, Autonomous University of Barcelona, Bellaterra, Spain (F.J.-A.).
Berraondo P; Program of Immunology and Immunotherapy, CIMA University of Navarra, Pamplona, Spain (P.B.).; Navarra Institute for Health Research (IDISNA), Pamplona, Spain (P.B.).
Egea G; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of Barcelona, Spain (C.A., I.R.-R., K.D.R., V.C., G.E.).; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (G.E.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Sep; Vol. 41 (9), pp. e440-e452. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Transfer Techniques*
Genetic Therapy*
Aorta/*metabolism
Aortic Aneurysm/*prevention & control
Marfan Syndrome/*complications
Peptide Fragments/*metabolism
Proteoglycans/*metabolism
Receptors, Transforming Growth Factor beta/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Aorta/pathology ; Aortic Aneurysm/genetics ; Aortic Aneurysm/metabolism ; Aortic Aneurysm/pathology ; Dependovirus/genetics ; Dilatation, Pathologic ; Disease Models, Animal ; Female ; Fibrillin-1/genetics ; Genetic Vectors ; Male ; Marfan Syndrome/genetics ; Mice, Inbred C57BL ; Peptide Fragments/genetics ; Proteoglycans/genetics ; Receptors, Transforming Growth Factor beta/genetics ; Signal Transduction ; Transforming Growth Factor beta/genetics
Czasopismo naukowe
Tytuł :
A tumor-promoting role for soluble TβRIII in glioblastoma.
Autorzy :
Burghardt I; Laboratory of Molecular Neuro-Oncology, Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.
Schroeder JJ; Laboratory of Molecular Neuro-Oncology, Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.
Weiss T; Laboratory of Molecular Neuro-Oncology, Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.
Gramatzki D; Laboratory of Molecular Neuro-Oncology, Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland.
Weller M; Laboratory of Molecular Neuro-Oncology, Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Aug; Vol. 476 (8), pp. 2963-2973. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carcinogens/*metabolism
Glioblastoma/*pathology
Proteoglycans/*metabolism
Receptors, Transforming Growth Factor beta/*metabolism
Smad2 Protein/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Humans ; Mice ; Middle Aged ; Prognosis ; Proteoglycans/genetics ; Receptors, Transforming Growth Factor beta/genetics ; Signal Transduction ; Smad2 Protein/genetics ; Survival Rate ; Transforming Growth Factor beta/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Effects of TGF-β1 Receptor Inhibitor GW788388 on the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells.
Autorzy :
Lho Y; Department of Internal Medicine, Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Do JY; Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Heo JY; Department of Internal Medicine, Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Kim AY; Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Kim SW; Division of Gastro-Enterology, Department of Surgery, College of Medicine, Yeungnam University, Daegu 42415, Korea.
Kang SH; Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 29; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Benzamides/*pharmacology
Epithelial Cells/*drug effects
Peritoneal Fibrosis/*pathology
Peritoneum/*cytology
Pyrazoles/*pharmacology
Receptor, Transforming Growth Factor-beta Type I/*antagonists & inhibitors
Animals ; Cell Movement/drug effects ; Cells, Cultured ; Chlorhexidine/analogs & derivatives ; Chlorhexidine/toxicity ; Collagen/metabolism ; Disease Models, Animal ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Peritoneal Fibrosis/chemically induced ; Peritoneum/drug effects ; Phosphorylation ; Protein Processing, Post-Translational ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Transforming Growth Factor beta/pharmacology ; Transforming Growth Factor beta1/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Synthesis and evaluation of the epithelial-to- mesenchymal inhibitory activity of indazole-derived imidazoles as dual ALK5/p38α MAP inhibitors.
Autorzy :
Liu YY; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China.
Guo Z; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China.
Wang JY; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China.
Wang HM; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China.
Da Qi J; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China.
Ma J; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China.
Piao HR; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China.
Jin CH; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China. Electronic address: .
Jin X; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, 133002, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113311. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article
MeSH Terms :
Imidazoles/*chemistry
Indazoles/*chemistry
Mitogen-Activated Protein Kinase 14/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemical synthesis
Receptor, Transforming Growth Factor-beta Type I/*antagonists & inhibitors
Binding Sites ; Cadherins/genetics ; Cadherins/metabolism ; Catalytic Domain ; Cell Line, Tumor ; Cell Movement/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Imidazoles/metabolism ; Imidazoles/pharmacology ; Mitogen-Activated Protein Kinase 14/metabolism ; Molecular Docking Simulation ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Structure-Activity Relationship ; Transforming Growth Factor beta/pharmacology ; Vimentin/genetics ; Vimentin/metabolism
Czasopismo naukowe
Tytuł :
TGFβ family signaling and development.
Autorzy :
Jia S; Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China .
Meng A; Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China .
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Źródło :
Development (Cambridge, England) [Development] 2021 Mar 12; Vol. 148 (5). Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Signal Transduction*
Embryonic Development/*physiology
Transforming Growth Factor beta/*metabolism
Animals ; Bone Morphogenetic Proteins/metabolism ; Germ Layers/metabolism ; Nodal Protein/metabolism ; Organogenesis ; Receptors, Transforming Growth Factor beta/metabolism ; Smad Proteins/metabolism ; Transforming Growth Factor beta/chemistry
Czasopismo naukowe
Tytuł :
Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling.
Autorzy :
Cinato M; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Guitou L; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Saidi A; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Timotin A; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Sperazza E; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Duparc T; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Zolov SN; Life Sciences Institute, University of Michigan, Ann Arbor, USA.
Giridharan SSP; Life Sciences Institute, University of Michigan, Ann Arbor, USA.
Weisman LS; Life Sciences Institute, University of Michigan, Ann Arbor, USA.
Martinez LO; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Roncalli J; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.; Department of Cardiology, Toulouse University Hospital, Toulouse, France.
Kunduzova O; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Tronchere H; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
Boal F; INSERM U1297 I2MC, Toulouse, France and Université Paul Sabatier, Toulouse, France.
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Źródło :
Theranostics [Theranostics] 2021 Apr 19; Vol. 11 (13), pp. 6491-6506. Date of Electronic Publication: 2021 Apr 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Heart Failure/*drug therapy
Hydrazones/*therapeutic use
Morpholines/*therapeutic use
Phosphatidylinositol 3-Kinases/*physiology
Pyrimidines/*therapeutic use
Signal Transduction/*drug effects
Transforming Growth Factor beta/*physiology
Animals ; Cells, Cultured ; Drug Evaluation, Preclinical ; Fibroblasts/drug effects ; Fibrosis ; HEK293 Cells ; HeLa Cells ; Heart Failure/pathology ; Humans ; Hydrazones/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Morpholines/pharmacology ; Myocardium/pathology ; Pyrimidines/pharmacology ; Rats ; Receptor, Transforming Growth Factor-beta Type II/drug effects ; Single-Blind Method ; Ventricular Dysfunction, Left/prevention & control ; Ventricular Remodeling/drug effects
Czasopismo naukowe
Tytuł :
Enhanced Intestinal TGF-β/SMAD-Dependent Signaling in Simian Immunodeficiency Virus Infected Rhesus Macaques.
Autorzy :
Boby N; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Ransom A; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Pace BT; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Williams KM; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Mabee C; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Das A; Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Srivastav SK; Department of Biostatistics, Tulane University, New Orleans, LA 70112, USA.
Porter E; Department of Biological Sciences, California State University Los Angeles, Los Angeles, CA 90032, USA.
Pahar B; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.; Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
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Źródło :
Cells [Cells] 2021 Apr 04; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Signal Transduction*
Intestines/*virology
Simian Acquired Immunodeficiency Syndrome/*metabolism
Simian Acquired Immunodeficiency Syndrome/*virology
Simian Immunodeficiency Virus/*physiology
Smad Proteins/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Disease Progression ; Down-Regulation ; Feedback, Physiological ; Gene Expression Regulation ; Intestines/pathology ; Macaca mulatta ; Models, Biological ; Phosphorylation ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; Simian Acquired Immunodeficiency Syndrome/blood ; Simian Acquired Immunodeficiency Syndrome/genetics ; Up-Regulation ; Viral Load
Czasopismo naukowe
Tytuł :
Garcimultiflorone K from Garcinia multiflora attenuates hepatocellular carcinoma metastasis by suppressing transforming growth factor-β signaling.
Autorzy :
Huang SF; Department of Medicine Chest, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan ROC.
Wang YL; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ROC.
Chen JJ; Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming Chiao-Tung University, Taipei 11221, Taiwan ROC; Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan ROC.
Huang YB; Department of Pharmacy, School of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC.
Tai SB; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ROC; Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, Taiwan ROC.
Chung CL; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ROC.
Chen CL; Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ROC; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Apr; Vol. 84, pp. 153502. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Phloroglucinol/*pharmacology
Transforming Growth Factor beta/*metabolism
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Garcinia/chemistry ; Hep G2 Cells ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/pathology ; Humans ; Liver Neoplasms/pathology ; Mice ; Phosphorylation/drug effects ; Rats ; Receptors, Transforming Growth Factor beta/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
YAP/TAZ and EZH2 synergize to impair tumor suppressor activity of TGFBR2 in non-small cell lung cancer.
Autorzy :
Lo Sardo F; UOSD Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Pulito C; UOSD Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Sacconi A; UOSD Clinical Trial Center, Biostatistics and Bioinformatics, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Korita E; UOSD Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Sudol M; Department of Physiology, National University of Singapore, Laboratory of Cancer Signaling & Domainopathies, Yong Loo Li School of Medicine, Block MD9, 2 Medical Drive #04-01, 117597, Republic of Singapore; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Strano S; SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: .
Blandino G; UOSD Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Mar 01; Vol. 500, pp. 51-63. Date of Electronic Publication: 2020 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Enhancer of Zeste Homolog 2 Protein/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
Receptor, Transforming Growth Factor-beta Type II/*genetics
Transcription Factors/*genetics
A549 Cells ; Carcinogenesis/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; DNA-Binding Proteins/genetics ; Epigenesis, Genetic/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; MicroRNAs/genetics ; Minichromosome Maintenance Complex Component 7/genetics ; Nuclear Proteins/genetics ; Receptor, Transforming Growth Factor-beta Type I/genetics ; Transforming Growth Factor beta1/genetics ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Tytuł :
AP2M1 Supports TGF-β Signals to Promote Collagen Expression by Inhibiting Caveolin Expression.
Autorzy :
Lee S; Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 10408, Korea.; Department of Biochemistry, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Lim GE; Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 10408, Korea.
Kim YN; Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 10408, Korea.
Koo HS; Department of Biochemistry, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Shim J; Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 10408, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 06; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 06.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Protein Complex 2/*genetics
Caenorhabditis elegans Proteins/*biosynthesis
Caenorhabditis elegans Proteins/*genetics
Caveolin 1/*biosynthesis
Collagen/*biosynthesis
Extracellular Matrix/*metabolism
Transforming Growth Factor beta/*metabolism
Adaptor Protein Complex 2/metabolism ; Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/metabolism ; Caveolin 1/genetics ; Collagen/genetics ; Endocytosis/genetics ; Glypicans/genetics ; RNA Interference ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Signal Transduction/physiology
Czasopismo naukowe

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