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Wyszukujesz frazę ""Transforming Growth Factor beta"" wg kryterium: Temat


Tytuł:
First-in-human study of GFH018, a small molecule inhibitor of transforming growth factor-β receptor I inhibitor, in patients with advanced solid tumors.
Autorzy:
Guo Y; Department of Medical Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Wang Z; The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Zhou H; The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
Pan H; Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Han W; Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Deng Y; Sixth Affiliated Hospital of Sun Yat-Sen University, Guangdong, China.
Li Q; Department of Medical Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Xue J; Department of Medical Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Ge X; Department of Medical Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Wang S; Clinical Department, GenFleet Therapeutics Inc, Shanghai, China.
Wang J; Translational Science, GenFleet Therapeutics Inc, Shanghai, China.
Zhang Y; Clinical Department, GenFleet Therapeutics Inc, Shanghai, China.
Zhao C; Clinical Department, GenFleet Therapeutics Inc, Shanghai, China.
Zhu H; Clinical Department, GenFleet Therapeutics Inc, Shanghai, China.
Wang Y; Clinical Department, GenFleet Therapeutics Inc, Shanghai, China.
Shen H; Clinical Department, GenFleet Therapeutics Inc, Shanghai, China.
Liu D; Translational Science, GenFleet Therapeutics Inc, Shanghai, China.
Li J; Department of Medical Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Apr 10; Vol. 24 (1), pp. 444. Date of Electronic Publication: 2024 Apr 10.
Typ publikacji:
Multicenter Study; Journal Article
MeSH Terms:
Neoplasms*/drug therapy
Neoplasms*/pathology
Receptors, Transforming Growth Factor beta*/antagonists & inhibitors
Adult ; Humans ; Response Evaluation Criteria in Solid Tumors ; Transforming Growth Factor beta
Czasopismo naukowe
Tytuł:
Tobacco Smoke Condensate Induces Morphologic Changes in Human Papillomavirus-Positive Cervical Epithelial Cells Consistent with Epithelial to Mesenchymal Transition (EMT) with Activation of Receptor Tyrosine Kinases and Regulation of TGFB .
Autorzy:
Mark ZA; Department of Biochemistry, Cancer Biology, Neuroscience, and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.; Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
Yu L; Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
Castro L; Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
Gao X; Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
Rodriguez NR; Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
Sutton D; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Scappini E; Signal Transduction Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Tucker CJ; Signal Transduction Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Wine R; Signal Transduction Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Yan Y; Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
Motley E; Department of Microbiology, Immunology, Physiology, Meharry Medical College, Nashville, TN 37208, USA.
Dixon D; Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 30; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 30.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*/drug effects
Transforming Growth Factor beta*/metabolism
Epithelial Cells*/metabolism
Epithelial Cells*/virology
Epithelial Cells*/drug effects
Humans ; Female ; Receptor Protein-Tyrosine Kinases/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Cervix Uteri/pathology ; Cervix Uteri/metabolism ; Cervix Uteri/virology ; Smoke/adverse effects ; Papillomavirus Infections/metabolism ; Papillomavirus Infections/virology ; Papillomavirus Infections/pathology ; Cell Proliferation/drug effects ; Cell Movement/drug effects ; Uterine Cervical Neoplasms/virology ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/etiology ; Human papillomavirus 16/pathogenicity ; Nicotiana/adverse effects ; Human Papillomavirus Viruses
Czasopismo naukowe
Tytuł:
Mechanical stimulation of induced pluripotent stem derived cardiac fibroblasts.
Autorzy:
Bekedam FT; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.
Smal R; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.
Smit MC; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.
Aman J; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.
Vonk-Noordegraaf A; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.
Bogaard HJ; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands.
Goumans MJ; Department of Cell and Chemical Biology, Leiden UMC, 2300 RC, Leiden, The Netherlands.
De Man FS; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. .; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands. .
Llucià-Valldeperas A; PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. .; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 29; Vol. 14 (1), pp. 9795. Date of Electronic Publication: 2024 Apr 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Induced Pluripotent Stem Cells*/cytology
Induced Pluripotent Stem Cells*/metabolism
Fibroblasts*/metabolism
Fibroblasts*/cytology
Transforming Growth Factor beta*/metabolism
Transforming Growth Factor beta*/pharmacology
Humans ; Stress, Mechanical ; Cells, Cultured ; Cell Differentiation ; Myocardium/cytology ; Myocardium/metabolism ; Myofibroblasts/metabolism ; Myofibroblasts/cytology ; Fibrosis
Czasopismo naukowe
Tytuł:
rhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals.
Autorzy:
Kathami N; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastian, Spain.; POLYMAT, University of the Basque Country (UPV-EHU), 20018, Donostia-San Sebastian, Spain.
Moreno-Vicente C; Complutense University of Madrid, 28040, Madrid, Spain.
Martín P; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastian, Spain.
Vergara-Arce JA; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastian, Spain.
Ruiz-Hernández R; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastian, Spain.
Gerovska D; Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, 20014, San Sebastián, Spain.
Aransay AM; Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160, Derio, Spain.; Centro de Investigación Biomedica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.
Araúzo-Bravo MJ; Computational Biology and Systems Biomedicine, Biodonostia Health Research Institute, 20014, San Sebastián, Spain.; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of Basque Country (UPV/EHU), 48940, Leioa, Spain.; IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Spain.
Camarero-Espinosa S; POLYMAT, University of the Basque Country (UPV-EHU), 20018, Donostia-San Sebastian, Spain.; IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Spain.
Abarrategi A; Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), 20014, Donostia-San Sebastian, Spain. .; IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Spain. .; Regenerative Medicine and Disease Models Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Paseo Miramón, 194, 20014, Donostia, Gipuzkoa, Spain. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2024 Apr 29; Vol. 15 (1), pp. 124. Date of Electronic Publication: 2024 Apr 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cells*/metabolism
Mesenchymal Stem Cells*/cytology
Mesenchymal Stem Cells*/drug effects
Bone Morphogenetic Protein 2*/pharmacology
Bone Morphogenetic Protein 2*/metabolism
Cell Differentiation*/drug effects
Recombinant Proteins*/pharmacology
Osteogenesis*/drug effects
Transforming Growth Factor beta*/metabolism
Transforming Growth Factor beta*/pharmacology
Humans ; Animals ; Chondrogenesis/drug effects ; Cells, Cultured ; Mice ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/drug effects ; Signal Transduction/drug effects ; Adipogenesis/drug effects
Czasopismo naukowe
Tytuł:
TGFβ-Responsive Stromal Activation Occurs Early in Serrated Colorectal Carcinogenesis.
Autorzy:
Tsumuraya H; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Okayama H; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Katagata M; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Matsuishi A; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Fukai S; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Ito M; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Sakamoto W; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Saito M; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Momma T; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Nakajima S; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.; Department of Multidisciplinary Treatment of Cancer and Regional Medical Support, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Mimura K; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
Kono K; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 24; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 24.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/pathology
Colorectal Neoplasms*/metabolism
Transforming Growth Factor beta*/metabolism
Transforming Growth Factor beta*/genetics
Stromal Cells*/metabolism
Stromal Cells*/pathology
Tumor Microenvironment*/genetics
Gene Expression Regulation, Neoplastic*
Proto-Oncogene Proteins B-raf*/genetics
Proto-Oncogene Proteins B-raf*/metabolism
Humans ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Mutation ; Transcriptome ; Signal Transduction ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Single-Cell Analysis ; Gene Expression Profiling ; Adenoma/genetics ; Adenoma/pathology ; Adenoma/metabolism
Czasopismo naukowe
Tytuł:
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding.
Autorzy:
Jatzlau J; Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany.
Burdzinski W; Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany.; Berlin-Brandenburg School for Regenerative Therapies (BSRT), Berlin, Germany.
Trumpp M; Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany.
Obendorf L; Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany.
Roßmann K; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Ravn K; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Hyvönen M; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Bottanelli F; Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany.
Broichhagen J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Knaus P; Institute of Chemistry and Biochemistry - Biochemistry, Berlin, Germany. .; Berlin-Brandenburg School for Regenerative Therapies (BSRT), Berlin, Germany. .
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Źródło:
Communications biology [Commun Biol] 2023 Jan 12; Vol. 6 (1), pp. 34. Date of Electronic Publication: 2023 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Transforming Growth Factor beta*/metabolism
Bone Morphogenetic Proteins*/metabolism
Bone Morphogenetic Protein Receptors ; Ligands ; Receptors, Transforming Growth Factor beta
Czasopismo naukowe
Tytuł:
Depletion of Tgfbr2 in hepatocytes alleviates liver fibrosis and restores hepatic function in fibrotic mice.
Autorzy:
Liu SQ; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Deng X; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Zhu CP; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Cui YL; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xie WF; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Zhang X; Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
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Źródło:
Journal of digestive diseases [J Dig Dis] 2023 Jan; Vol. 24 (1), pp. 39-50. Date of Electronic Publication: 2023 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*/metabolism
Hepatocytes*/pathology
Liver Cirrhosis*/pathology
Receptor, Transforming Growth Factor-beta Type II*
Animals ; Mice ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Liver/pathology ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł:
Aberrant activation of TGF-β/ROCK1 enhances stemness during prostatic stromal hyperplasia.
Autorzy:
Li Y; Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Li J; Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Zhou L; Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.
Wang Z; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Jin L; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Cao J; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xie H; Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. .
Wang L; Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 May 06; Vol. 22 (1), pp. 257. Date of Electronic Publication: 2024 May 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
rho-Associated Kinases*/metabolism
Prostatic Hyperplasia*/pathology
Prostatic Hyperplasia*/metabolism
Mesenchymal Stem Cells*/metabolism
Mesenchymal Stem Cells*/pathology
Transforming Growth Factor beta*/metabolism
Male ; Humans ; Animals ; Cell Differentiation ; Prostate/pathology ; Prostate/metabolism ; Cell Movement ; Mice ; Stromal Cells/metabolism ; Stromal Cells/pathology
Czasopismo naukowe
Tytuł:
Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds.
Autorzy:
Gumede DB; Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa.
Abrahamse H; Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa.
Houreld NN; Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Apr 26; Vol. 22 (1), pp. 244. Date of Electronic Publication: 2024 Apr 26.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Wound Healing*
Wnt Signaling Pathway*
Receptors, Notch*/metabolism
Transforming Growth Factor beta*/metabolism
Humans ; Animals ; Chronic Disease ; beta Catenin/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Hydrostatic pressure mediates epithelial-mesenchymal transition of cholangiocytes through RhoA/ROCK and TGF-β/smad pathways.
Autorzy:
Khalifa MO; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.; Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.; Department of Anatomy and Embryology, Veterinary Medicine, Aswan University, Aswan, Egypt.
Yan C; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Chai Y; Department of General Surgery, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China.
Ito K; Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Zhang SH; Department of General Surgery, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China.
Li TS; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
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Źródło:
PloS one [PLoS One] 2024 Apr 05; Vol. 19 (4), pp. e0300548. Date of Electronic Publication: 2024 Apr 05 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Transforming Growth Factor beta*/metabolism
Humans ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition ; Hydrostatic Pressure ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł:
A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response.
Autorzy:
Duan WW; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang LT; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liu J; Experiment Center of Medical Innovation, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Dai ZY; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wang ZY; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Zhang H; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhang X; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liang XS; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Luo P; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhang J; Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Liu ZQ; Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhang N; One-third Lab, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Hei Longjiang, China.
Mo HY; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qu CR; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xia ZW; Department of Neurology, Hunan Aerospace Hospital, Changsha, Hunan, China.
Cheng Q; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Apr; Vol. 30 (4), pp. e14489. Date of Electronic Publication: 2023 Oct 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glioma*/genetics
Glioma*/therapy
RNA, Long Noncoding*/genetics
Transforming Growth Factor beta*/metabolism
Humans ; NF-kappa B ; Prognosis ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Immunotherapy/methods
Czasopismo naukowe
Tytuł:
Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
Autorzy:
Du X; Department of Orthopedics, Beijing Geriatric Hospital, No.118 Hot Spring Road, Haidian District 100095, Beijing, China.
Zang C; Department of Orthopedics, Beijing Geriatric Hospital, No.118 Hot Spring Road, Haidian District 100095, Beijing, China.
Wang Q; Department of Orthopedics, Beijing Geriatric Hospital, No.118 Hot Spring Road, Haidian District 100095, Beijing, China. .
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Źródło:
BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2024 Mar 07; Vol. 25 (1), pp. 206. Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Anthraquinones*
Osteoporosis*/chemically induced
Transforming Growth Factor beta*/metabolism
Animals ; Female ; Humans ; Mice ; Alkaline Phosphatase/metabolism ; Cell Differentiation ; Cyclin A1/metabolism ; Osteoblasts/metabolism ; Osteogenesis ; Transforming Growth Factors/adverse effects ; Transforming Growth Factors/metabolism
Czasopismo naukowe
Tytuł:
Analysis of immunoinfiltration and EndoMT based on TGF-β signaling pathway-related genes in acute myocardial infarction.
Autorzy:
Shen J; Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. .; Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, China. .
Liang J; Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Rejiepu M; Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Ma Z; Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Zhao J; Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Li J; Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
Zhang L; Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. .
Yuan P; Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, China. .
Wang J; Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, China. .
Tang B; Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 02; Vol. 14 (1), pp. 5183. Date of Electronic Publication: 2024 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Transforming Growth Factor beta*/metabolism
Myocardial Infarction*/pathology
Rats ; Animals ; Rats, Sprague-Dawley ; Endothelial Cells/metabolism ; Signal Transduction/genetics ; Fibrosis
Czasopismo naukowe
Tytuł:
MiR-302d inhibits TGFB-induced EMT and promotes MET in primary human RPE cells.
Autorzy:
Hu X; Institute of Ophthalmology, University Eye Hospital, Hannover Medical School, Hannover, Germany.
Binter M; Institute of Ophthalmology, University Eye Hospital, Hannover Medical School, Hannover, Germany.
Hufendiek K; Institute of Ophthalmology, University Eye Hospital, Hannover Medical School, Hannover, Germany.
Tode J; Institute of Ophthalmology, University Eye Hospital, Hannover Medical School, Hannover, Germany.
Framme C; Institute of Ophthalmology, University Eye Hospital, Hannover Medical School, Hannover, Germany.
Fuchs H; Institute of Ophthalmology, University Eye Hospital, Hannover Medical School, Hannover, Germany.
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Źródło:
PloS one [PLoS One] 2022 Nov 28; Vol. 17 (11), pp. e0278158. Date of Electronic Publication: 2022 Nov 28 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Transforming Growth Factor beta*
MicroRNAs*/genetics
Humans ; Epithelial-Mesenchymal Transition/genetics ; Receptor, Transforming Growth Factor-beta Type II ; Retinal Pigment Epithelium ; Vascular Endothelial Growth Factor A/genetics ; Fibrosis
Czasopismo naukowe
Tytuł:
Activin A Modulates Betaglycan Shedding via the ALK4-SMAD3-Dependent Pathway in Endometriotic Cells.
Autorzy:
Mwaura AN; Faculty of Medicine, Center of Gynecology and Obstetrics, Justus-Liebig-University, D-35392 Giessen, Germany.
Riaz MA; Faculty of Medicine, Center of Gynecology and Obstetrics, Justus-Liebig-University, D-35392 Giessen, Germany.
Maoga JB; Faculty of Medicine, Center of Gynecology and Obstetrics, Justus-Liebig-University, D-35392 Giessen, Germany.
Mecha E; Department of Biochemistry, University of Nairobi, Nairobi P.O. Box 30197-00100, Kenya.
Omwandho COA; Department of Biochemistry, University of Nairobi, Nairobi P.O. Box 30197-00100, Kenya.; Department of Health Sciences, Kirinyaga University, Kerugoya P.O. Box 143-10300, Kenya.
Scheiner-Bobis G; Institute for Veterinary Physiology and Biochemistry, School of Veterinary Medicine, Justus-Liebig-University, D-35392 Giessen, Germany.
Meinhold-Heerlein I; Faculty of Medicine, Center of Gynecology and Obstetrics, Justus-Liebig-University, D-35392 Giessen, Germany.
Konrad L; Faculty of Medicine, Center of Gynecology and Obstetrics, Justus-Liebig-University, D-35392 Giessen, Germany.
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Źródło:
Biomolecules [Biomolecules] 2022 Nov 24; Vol. 12 (12). Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Activins*/pharmacology
Activins*/metabolism
Endometriosis*/metabolism
Receptors, Transforming Growth Factor beta*/metabolism
Activin Receptors, Type I*
Female ; Humans ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 3/genetics ; Matrix Metalloproteinase 3/metabolism ; Smad3 Protein/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł:
Regulation of metabolic homeostasis by the TGF-β superfamily receptor ALK7.
Autorzy:
Ibáñez CF; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.; Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University School of Life Sciences and Chinese Institute for Brain Research, Beijing, China.; Department of Physiology and Life Sciences Institute, National University of Singapore, Singapore.
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Źródło:
The FEBS journal [FEBS J] 2022 Oct; Vol. 289 (19), pp. 5776-5797. Date of Electronic Publication: 2021 Jul 11.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin-Secreting Cells*/metabolism
Receptors, Transforming Growth Factor beta*/genetics
Activin Receptors, Type I/genetics ; Activin Receptors, Type I/metabolism ; Animals ; Homeostasis ; Humans ; Mammals/metabolism ; Mice ; Signal Transduction/genetics ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł:
Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling.
Autorzy:
Kolbe N; Institute of Geometry and Practical Mathematics, RWTH Aachen University, Aachen, Germany.
Hexemer L; Institute of Molecular Biology (IMB), Mainz, Germany.; Department of Systems Biology, Institute for Biomedical Genetics (IBMG), University of Stuttgart, Stuttgart, Germany.
Bammert LM; Institute of Mathematics, Johannes Gutenberg-University, Mainz, Germany.
Loewer A; Systems Biology of the Stress Response, Department of Biology, Technical University of Darmstadt, Darmstadt, Germany.
Lukáčová-Medvid'ová M; Institute of Mathematics, Johannes Gutenberg-University, Mainz, Germany.
Legewie S; Department of Systems Biology, Institute for Biomedical Genetics (IBMG), University of Stuttgart, Stuttgart, Germany.; Stuttgart Research Center for Systems Biology (SRCSB), University of Stuttgart, Stuttgart, Germany.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2022 Jun 27; Vol. 18 (6), pp. e1010266. Date of Electronic Publication: 2022 Jun 27 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Receptors, Transforming Growth Factor beta*
Signal Transduction*/physiology
Cell Nucleus/metabolism ; Endosomes/metabolism ; Smad Proteins/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł:
Dysregulated miRNA-375, IL-17, TGF-β, and Microminerals Are Associated with Calpain-10 SNP 19 in Diabetic Patients: Correlation with Diabetic Nephropathy Stages.
Autorzy:
Ezzat GM; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
Azoz NMA; Department of Internal Medicine, Nephrology Unit, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
El Zohne RA; Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
Abdellatif H; Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
Saleem TH; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.
Emam WA; Biochemistry Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo 11351, Egypt.
Mohammed AR; Biochemistry Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo 11351, Egypt.
Mohamed SA; Biochemistry Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo 11351, Egypt.
Muhammed AA; Department of Medical Physiology, Faculty of Medicine, Aswan University, Aswan 81511, Egypt.
Abd El-Rady NM; Medical Physiology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.; Medical Physiology Department, Sphinx University, New Assiut 71515, Egypt.
Hamdy M; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt.
Sherkawy HS; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Aswan University, Aswan 81528, Egypt.
Sabet MA; Department of Microbiology and Immunology, Faculty of Pharmacy, Sphinx University, New Assiut 71684, Egypt.
Seif Eldin S; Department of Medical Microbiology and Immunology, College of Medicine, Assiut University, Assiut 71515, Egypt.; Department of Basic Medical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Dahpy MA; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.; Department of Medical Biochemistry and Molecular Biology, Armed Forces College of Medicine (AFCM), Cairo 11774, Egypt.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 13; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/genetics
Diabetic Nephropathies*
Interleukin-17*/metabolism
MicroRNAs*/genetics
Transforming Growth Factor beta*/genetics
Transforming Growth Factor beta*/metabolism
Humans ; Calpain/genetics ; Copper ; Zinc
Czasopismo naukowe
Tytuł:
Shenhuang plaster enhances intestinal anastomotic healing in rabbits through activation of the TGF-β and Hippo/YAP signaling pathways.
Autorzy:
Xiao F
Zhu C
Wei X; The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, Zhejiang, China.
Chen G
Xu X
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Źródło:
Journal of applied biomedicine [J Appl Biomed] 2023 Dec; Vol. 21 (4), pp. 208-217. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Transforming Growth Factor beta*/metabolism
Transforming Growth Factor beta*/pharmacology
Lagomorpha*/metabolism
Animals ; Humans ; Rabbits ; Transforming Growth Factor beta1/pharmacology ; Hydroxyproline/pharmacology ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/pharmacology ; Signal Transduction ; Collagen/pharmacology ; Anastomosis, Surgical
Czasopismo naukowe
Tytuł:
A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila.
Autorzy:
Peterson AJ; Department of Genetics, Cell Biology & Development and the Developmental Biology Center, University of Minnesota, Minneapolis, Minnesota, United States of America.
Murphy SJ; Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Mundt MG; Department of Genetics, Cell Biology & Development and the Developmental Biology Center, University of Minnesota, Minneapolis, Minnesota, United States of America.
Shimell M; Department of Genetics, Cell Biology & Development and the Developmental Biology Center, University of Minnesota, Minneapolis, Minnesota, United States of America.
Leof EB; Thoracic Diseases Research Unit, Department of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
O'Connor MB; Department of Genetics, Cell Biology & Development and the Developmental Biology Center, University of Minnesota, Minneapolis, Minnesota, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2022 May 20; Vol. 20 (5), pp. e3001660. Date of Electronic Publication: 2022 May 20 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Drosophila*/metabolism
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Transforming Growth Factor beta*/genetics
Transforming Growth Factor beta*/metabolism
Animals ; Cell Membrane/metabolism ; Dogs ; Female ; Ligands ; Madin Darby Canine Kidney Cells ; Protein Serine-Threonine Kinases ; Receptors, Cell Surface/metabolism ; Receptors, Transforming Growth Factor beta/metabolism
Czasopismo naukowe

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