Temat: "Transforming Growth Factor beta" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: New Insights into the Role of KLF10 in Tissue Fibrosis.
Autorzy:: Yaseen U; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea.
Hwang S; Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon 21999, Republic of Korea.
Park S; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea.
Kim SB; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea.
Lee HJ; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea.; Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon 21999, Republic of Korea.
Cha JY; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea.; Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, Incheon 21999, Republic of Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Fibrosis*/metabolism
Fibrosis*/pathology
Kruppel-Like Transcription Factors*/metabolism
Humans ; Early Growth Response Transcription Factors/genetics ; Transcription Factors/metabolism ; Transforming Growth Factor beta/metabolism ; Animals

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Tytuł:: Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Autorzy:: Monkley S; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Overed-Sayer C; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Parfrey H; Cambridge Interstitial Lung Disease Service, Royal Papworth Hospital, Cambridge, UK.
Rassl D; Royal Papworth Hospital, Cambridge, UK.
Crowther D; Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Escudero-Ibarz L; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Davis N; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Carruthers A; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Berks R; Biological Services Group, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.
Coetzee M; Babraham Institute, Cambridge, UK.
Kolosionek E; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Karlsson M; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Griffin LR; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Clausen M; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Belfield G; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Hogaboam CM; Cedars-Sinai Department of Medicine, Los Angeles, CA, 90048, USA.
Murray LA; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Nov 03; Vol. 11 (1), pp. 21584. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:: Journal Article
MeSH Terms:: Cellular Senescence*
Unfolded Protein Response*
Fibrosis/*metabolism
Protein Phosphatase 1/*genetics
Aged ; Animals ; Bleomycin ; Cell Differentiation ; Cell Proliferation ; Endoplasmic Reticulum Stress ; Female ; Fibroblasts/metabolism ; Genotype ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Indoles/pharmacology ; Lung/metabolism ; Male ; Mesoderm/cytology ; Mice ; Middle Aged ; Morpholines/pharmacology ; Protein Phosphatase 1/physiology ; Sequence Analysis, RNA ; Transforming Growth Factor beta/metabolism

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Skocz do pozycji: 3.

Tytuł:: TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment.
Autorzy:: Chung JY; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Chan MK; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Li JS; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Chan AS; Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong, China.
Tang PC; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Leung KT; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
To KF; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.
Lan HY; Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Tang PM; Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 15; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Cancer-Associated Fibroblasts/*pathology
Fibrosis/*pathology
Neoplasms/*metabolism
Neoplasms/*pathology
Transforming Growth Factor beta/*metabolism
Animals ; Cancer-Associated Fibroblasts/metabolism ; Fibrosis/metabolism ; Humans ; Neoplasms/blood supply ; Neoplasms/immunology ; Neovascularization, Pathologic/pathology ; Signal Transduction ; Tumor Microenvironment

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Skocz do pozycji: 4.

Tytuł:: Organ Fibrosis and Autoimmunity: The Role of Inflammation in TGFβ-Dependent EMT.
Autorzy:: Sisto M; Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari 'Aldo Moro', 70124 Bari, Italy.
Ribatti D; Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari 'Aldo Moro', 70124 Bari, Italy.
Lisi S; Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari 'Aldo Moro', 70124 Bari, Italy.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2021 Feb 18; Vol. 11 (2). Date of Electronic Publication: 2021 Feb 18.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Autoimmunity/*physiology
Epithelial-Mesenchymal Transition/*physiology
Fibrosis/*metabolism
Inflammation/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Autoimmunity/genetics ; Epithelial-Mesenchymal Transition/genetics ; Fibrosis/genetics ; Humans ; Inflammation/genetics

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Skocz do pozycji: 5.

Tytuł:: Cellular and molecular mechanisms in fibrosis.
Autorzy:: Dees C; Friedrich-Alexander-University (FAU) Erlangen-Nürnberg, Department of Internal Medicine 3-Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany.
Chakraborty D; Friedrich-Alexander-University (FAU) Erlangen-Nürnberg, Department of Internal Medicine 3-Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany.
Distler JHW; Friedrich-Alexander-University (FAU) Erlangen-Nürnberg, Department of Internal Medicine 3-Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany.; Pokaż więcej
Źródło:: Experimental dermatology [Exp Dermatol] 2021 Jan; Vol. 30 (1), pp. 121-131. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Signal Transduction*
Fibrosis/*metabolism
Idiopathic Pulmonary Fibrosis/*metabolism
Scleroderma, Systemic/*metabolism
Skin/*pathology
Transforming Growth Factor beta/*metabolism
Animals ; DNA Methylation ; Ephrins/metabolism ; Fibroblast Growth Factor 9/metabolism ; Fibrosis/genetics ; Fibrosis/pathology ; Guanylate Cyclase/metabolism ; Histone Code ; Humans ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/pathology ; Janus Kinases/metabolism ; Myofibroblasts ; Receptors, Cytoplasmic and Nuclear/metabolism ; STAT Transcription Factors/metabolism ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/pathology ; Serotonin/metabolism

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Skocz do pozycji: 6.

Tytuł:: Transforming growth factor β-inhibitor Repsox downregulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.
Autorzy:: Ide M; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Jinnin M; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Tomizawa Y; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Wang Z; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kajihara I; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Fukushima S; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hashizume Y; RIKEN Program for Drug Discovery and Medical Technology Platforms, Wako, Saitama, Japan.
Asano Y; Department of Dermatology, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Ihn H; Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.; Pokaż więcej
Źródło:: Experimental dermatology [Exp Dermatol] 2017 Nov; Vol. 26 (11), pp. 1139-1143. Date of Electronic Publication: 2017 Aug 25.
Typ publikacji:: Letter
MeSH Terms:: Collagen Type I/*metabolism
Fibrosis/*prevention & control
Pyrazoles/*pharmacology
Pyridines/*pharmacology
Scleroderma, Systemic/*metabolism
Skin/*pathology
Transforming Growth Factor beta/*antagonists & inhibitors
Actins/metabolism ; Amino Acids/pharmacology ; Aminopyridines/pharmacology ; Animals ; Bleomycin ; Collagen Type I, alpha 1 Chain ; Connective Tissue Growth Factor/metabolism ; Fibroblasts ; Fibrosis/chemically induced ; Humans ; Inhibitory Concentration 50 ; Mice ; Phenols/pharmacology ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Pyrroles/pharmacology ; Scleroderma, Systemic/pathology ; Signal Transduction/drug effects ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta/pharmacology ; Up-Regulation/drug effects ; Xanthenes/pharmacology

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Skocz do pozycji: 7.

Tytuł:: Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model.
Autorzy:: Jiang Y; Department of Nephrology, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, 185 Puan Road, Shanghai, 200021, People's Republic of China.; Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, People's Republic of China.
Zhu Y; Department of Nephrology, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, 185 Puan Road, Shanghai, 200021, People's Republic of China.; Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, People's Republic of China.
Zhen T; Shanghai Cinoasia Institute, Shanghai, 200438, People's Republic of China.
Li J; Shanghai Cinoasia Institute, Shanghai, 200438, People's Republic of China.
Xing K; Shanghai Cinoasia Institute, Shanghai, 200438, People's Republic of China.
He L; Department of Nephrology, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, 185 Puan Road, Shanghai, 200021, People's Republic of China. .; Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai, People's Republic of China. .
Zhu S; School of Life Sciences, Fudan University, 2005 Songhu Road, Shanghai, 200438, People's Republic of China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jun 30; Vol. 10 (1), pp. 10682. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drugs, Chinese Herbal/*pharmacology
Fibrosis/*drug therapy
Fibrosis/*genetics
Kidney Diseases/*drug therapy
Kidney Diseases/*genetics
Transcriptome/*drug effects
Transcriptome/*genetics
Animals ; Disease Models, Animal ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Profiling/methods ; Kidney/drug effects ; Kidney/pathology ; Male ; Medicine, Chinese Traditional/methods ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Transforming Growth Factor beta/genetics ; Ureteral Obstruction/drug therapy ; Ureteral Obstruction/genetics ; Urinary Tract/drug effects

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Skocz do pozycji: 8.

Tytuł:: Topically Applied Cross-Linked Hyaluronan Attenuates the Formation of Spinal Epidural Fibrosis in a Swine Model of Laminectomy.
Autorzy:: Lin CL; Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Skeleton Materials and Bio-compatibility Core Lab, Research Center of Clinical Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jou IM; Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Wu CY; Department of Orthopedics, Chia Yi Christian Hospital, Chia Yi, Taiwan.
Kuo YR; Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yang SC; Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Lee JS; Division of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan.
Tu YK; Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chen SC; Maxigen Biotech Inc., Taoyuan, Taiwan.
Huang YH; Department of Orthopedics, Chia Yi Christian Hospital, Chia Yi, Taiwan. .; Department of sports management, Chia Nan University of Pharmacy & Science, Tainan, Taiwan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Oct 10; Vol. 9 (1), pp. 14613. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji:: Journal Article
MeSH Terms:: Laminectomy*
Epidural Space/*physiopathology
Fibrosis/*physiopathology
Hyaluronic Acid/*administration & dosage
Administration, Topical ; Animals ; Butylene Glycols/chemistry ; Cicatrix/metabolism ; Cross-Linking Reagents/chemistry ; Fibrosis/diagnostic imaging ; Hyaluronan Receptors/metabolism ; Interleukin-6/metabolism ; Magnetic Resonance Imaging ; Male ; Matrix Metalloproteinase 3/metabolism ; Matrix Metalloproteinase 9/metabolism ; Models, Animal ; Swine ; Transforming Growth Factor beta/metabolism ; Vimentin/metabolism

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Skocz do pozycji: 9.

Tytuł:: Human Umbilical Cord Mesenchymal Stem Cells Extricate Bupivacaine-Impaired Skeletal Muscle Function via Mitigating Neutrophil-Mediated Acute Inflammation and Protecting against Fibrosis.
Autorzy:: Su WH; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .; Stem Cell Research Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .
Wang CJ; Department of Orthopedics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. .; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .
Fu HC; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. .
Sheng CM; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .
Tsai CC; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .; Stem Cell Research Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .
Cheng JH; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .
Chuang PC; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .; Stem Cell Research Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. .; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Sep 03; Vol. 20 (17). Date of Electronic Publication: 2019 Sep 03.
Typ publikacji:: Journal Article
MeSH Terms:: Fibrosis/*drug therapy
Fibrosis/*therapy
Inflammation/*metabolism
Mesenchymal Stem Cells/*physiology
Neutrophils/*metabolism
Animals ; Fibrosis/metabolism ; Humans ; Inflammation/drug therapy ; Inflammation/therapy ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Neutrophil Infiltration/drug effects ; Signal Transduction/drug effects ; Transforming Growth Factor beta/pharmacology ; Umbilical Cord/cytology

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Skocz do pozycji: 10.

Tytuł:: Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients.
Autorzy:: Shi J; Department of Infectious Diseases, 302 Military Hospital of China-Peking University Teaching Hospital, Beijing, 100039, China.
Zhao J; Research Center for Clinical &Translational Medicine, Beijing 302 Hospital, Beijing, 100039, China.
Zhang X; Department of Infectious Diseases, Beijing 302 Hospital, Beijing, 100039, China.
Cheng Y; Research Center for International Liver Disease, Beijing 302 Hospital, Beijing 100039, China.
Hu J; Research Center for Liver Failure, Beijing 302 Hospital, Beijing, 100039, China.
Li Y; Department of Infectious Diseases, Beijing 302 Hospital, Beijing, 100039, China.
Zhao X; Forensic Sursery Center, Beijing 302 Hospital, Beijing, 100039, China.
Shang Q; Department of Infectious Diseases, 88th Hospital of PLA, Taian, 271000, China.
Sun Y; Research Center for Clinical &Translational Medicine, Beijing 302 Hospital, Beijing, 100039, China.
Tu B; Department of Infectious Diseases, Beijing 302 Hospital, Beijing, 100039, China.
Shi L; Department of Infectious Diseases, Beijing 302 Hospital, Beijing, 100039, China.
Gao B; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Wang FS; Department of Infectious Diseases, 302 Military Hospital of China-Peking University Teaching Hospital, Beijing, 100039, China.
Zhang Z; Research Center for Clinical &Translational Medicine, Beijing 302 Hospital, Beijing, 100039, China.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 Mar 14; Vol. 7, pp. 44544. Date of Electronic Publication: 2017 Mar 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Fibrosis/*genetics
Hepatitis B, Chronic/*genetics
Liver Cirrhosis/*genetics
Transforming Growth Factor beta/*genetics
Adult ; Aged ; Animals ; Emperipolesis/genetics ; Emperipolesis/immunology ; Female ; Fibrosis/immunology ; Fibrosis/pathology ; Hepatic Stellate Cells/immunology ; Hepatic Stellate Cells/pathology ; Hepatitis B, Chronic/immunology ; Hepatitis B, Chronic/pathology ; Hepatitis B, Chronic/virology ; Humans ; Interferon-gamma/genetics ; Killer Cells, Natural/immunology ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/immunology ; Liver Cirrhosis/pathology ; Male ; Mice ; Middle Aged ; Transforming Growth Factor beta/administration & dosage

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Skocz do pozycji: 11.

Tytuł:: The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-β1.
Autorzy:: Lawson JS; Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom.
Liu HH; Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom.
Syme HM; Clinical Sciences and Services, The Royal Veterinary College, North Mymms, Hatfield, Herts, United Kingdom.
Purcell R; Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom.
Wheeler-Jones CPD; Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom.
Elliott J; Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Aug 23; Vol. 13 (8), pp. e0202577. Date of Electronic Publication: 2018 Aug 23 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Fibrosis/*genetics
Inflammation/*genetics
Kidney/*physiopathology
Renal Insufficiency, Chronic/*genetics
Transforming Growth Factor beta1/*genetics
Animals ; Benzamides/administration & dosage ; Cats ; Cell Cycle Checkpoints/drug effects ; Cell Dedifferentiation/drug effects ; Cells, Cultured ; Dioxoles/administration & dosage ; Disease Models, Animal ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Epithelial-Mesenchymal Transition/drug effects ; Fibrosis/physiopathology ; Humans ; Inflammation/physiopathology ; Kidney/drug effects ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/physiopathology ; Receptor, Transforming Growth Factor-beta Type I/antagonists & inhibitors ; Receptor, Transforming Growth Factor-beta Type I/genetics ; Renal Insufficiency, Chronic/physiopathology ; Signal Transduction ; Transforming Growth Factor beta1/administration & dosage ; Urinary Tract/physiopathology

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Skocz do pozycji: 12.

Tytuł:: Irregular pacing of ventricular cardiomyocytes induces pro-fibrotic signalling involving paracrine effects of transforming growth factor beta and connective tissue growth factor.
Autorzy:: Slawik J; Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Saarland University, Germany.
Adrian L; Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Saarland University, Germany.
Hohl M; Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Saarland University, Germany.
Lothschütz S; Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Saarland University, Germany.
Laufs U; Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Leipzig, Germany.
Böhm M; Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg, Saarland University, Germany.; Pokaż więcej
Źródło:: European journal of heart failure [Eur J Heart Fail] 2019 Apr; Vol. 21 (4), pp. 482-491. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Atrial Fibrillation/*metabolism
Connective Tissue Growth Factor/*biosynthesis
Fibrosis/*metabolism
Myocytes, Cardiac/*metabolism
Transforming Growth Factor beta/*biosynthesis
Animals ; Atrial Fibrillation/physiopathology ; Cells, Cultured ; Female ; Fibrillar Collagens/biosynthesis ; Fibroblasts/metabolism ; Heart Ventricles/metabolism ; Heart Ventricles/physiopathology ; Male ; Oxidative Stress ; Paracrine Communication ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species ; Signal Transduction

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Skocz do pozycji: 13.

Tytuł:: Mechanisms involved in the arthrofibrosis formation and treatments following bone fracture.
Autorzy:: Wang MM; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.
Feng YS; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.
Xing Y; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.
Dong F; Department of Clinical Laboratory Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.
Zhang F; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.; Hebei Provincial Orthopedic Biomechanics key laboratory, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China.; Pokaż więcej
Źródło:: Journal of back and musculoskeletal rehabilitation [J Back Musculoskelet Rehabil] 2019; Vol. 32 (6), pp. 947-954.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Fibrosis*/therapy
Fractures, Bone/*complications
Joints/*pathology
Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Bone Morphogenetic Protein 2/metabolism ; Debridement ; Humans ; Injections, Intra-Articular ; Manipulation, Orthopedic ; Mitogen-Activated Protein Kinase 1/metabolism ; Platelet-Derived Growth Factor/metabolism ; Risk Factors ; Splints ; Substance P/metabolism ; Tissue Adhesions/surgery ; Transforming Growth Factor beta/metabolism

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Skocz do pozycji: 14.

Tytuł:: Histone deacetylase inhibitor, CG200745 attenuates renal fibrosis in obstructive kidney disease.
Autorzy:: Choi HS; Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 61469, South Korea.
Song JH; Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 61469, South Korea.
Kim IJ; Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 61469, South Korea.
Joo SY; Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 61469, South Korea.
Eom GH; Department of Pharmacology, Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, 61469, South Korea.
Kim I; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea.
Cha H; CrystalGenomics, Inc., 5 F, Bldg A, Korea Bio Park, Seongnam, 13488, Korea.
Cho JM; CrystalGenomics, Inc., 5 F, Bldg A, Korea Bio Park, Seongnam, 13488, Korea.
Ma SK; Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 61469, South Korea.
Kim SW; Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 61469, South Korea. .
Bae EH; Departments of Internal Medicine, Chonnam National University Medical School, Gwangju, 61469, South Korea. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Aug 01; Vol. 8 (1), pp. 11546. Date of Electronic Publication: 2018 Aug 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Fibrosis/*drug therapy
Histone Deacetylase Inhibitors/*administration & dosage
Hydroxamic Acids/*administration & dosage
Naphthalenes/*administration & dosage
Ureteral Obstruction/*complications
Animals ; Cell Line ; Disease Models, Animal ; Epithelial Cells/drug effects ; Fibrosis/pathology ; Humans ; Kidney/pathology ; Lipocalins/blood ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; Protein Processing, Post-Translational ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism ; Transforming Growth Factor beta/analysis ; Treatment Outcome

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Skocz do pozycji: 15.

Tytuł:: A cationic-independent mannose 6-phosphate receptor inhibitor (PXS64) ameliorates kidney fibrosis by inhibiting activation of transforming growth factor-β1.
Autorzy:: Zhang J; Kolling Institute of Medical Research, Sydney, Australia.
Wong MG; Kolling Institute of Medical Research, Sydney, Australia.
Wong M; Kolling Institute of Medical Research, Sydney, Australia.
Gross S; Kolling Institute of Medical Research, Sydney, Australia.
Chen J; Royal North Shore Hospital, St. Leonards, Australia.
Pollock C; Kolling Institute of Medical Research, Sydney, Australia.
Saad S; Kolling Institute of Medical Research, Sydney, Australia.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 Feb 06; Vol. 10 (2), pp. e0116888. Date of Electronic Publication: 2015 Feb 06 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Fibrosis/*drug therapy
Kidney/*pathology
Kidney Tubules/*drug effects
Mannosides/*pharmacology
Organophosphonates/*pharmacology
Transforming Growth Factor beta/*metabolism
Animals ; Cells, Cultured ; Disease Models, Animal ; Fibrosis/genetics ; Fibrosis/metabolism ; Fibrosis/pathology ; Gene Expression Regulation/drug effects ; Humans ; Kidney/drug effects ; Kidney Tubules/cytology ; Kidney Tubules/metabolism ; Male ; Mice, Inbred C57BL ; Neutrophils/drug effects ; Prodrugs/pharmacology ; Smad2 Protein/metabolism ; Transforming Growth Factor beta/pharmacology ; Ureteral Obstruction/pathology

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Skocz do pozycji: 16.

Tytuł:: Anti-Renal Fibrotic Effect of Exercise Training in Hypertension.
Autorzy:: Huang C; Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan. .; College of Medicine, China Medical University, Taichung 40402, Taiwan. .; Graduate Program of Translational Medicine, China Medical University, Taichung 40402, Taiwan. .
Lin YY; Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan. .
Yang AL; Department of Sports Sciences, University of Taipei, Taipei 11153, Taiwan. .
Kuo TW; Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taichung 40402, Taiwan. .
Kuo CH; Department of Sports Sciences, University of Taipei, Taipei 11153, Taiwan. .; Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taichung 40402, Taiwan. .
Lee SD; Department of Sports Sciences, University of Taipei, Taipei 11153, Taiwan. .; Department of Occupational Therapy, Asia University, Taichung 41354, Taiwan. .; School of Rehabilitation Science, Shanghai University of TCM, Shanghai 201203, China. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2018 Feb 20; Vol. 19 (2). Date of Electronic Publication: 2018 Feb 20.
Typ publikacji:: Journal Article
MeSH Terms:: Exercise Therapy*
Fibrosis/*therapy
Hypertension/*therapy
Kidney Diseases/*therapy
Animals ; Connective Tissue Growth Factor/genetics ; Cyclooxygenase 2/genetics ; Fibrosis/genetics ; Fibrosis/physiopathology ; Gene Expression Regulation/genetics ; Humans ; Hypertension/genetics ; Hypertension/physiopathology ; Interleukin-6/genetics ; Kidney Diseases/genetics ; Kidney Diseases/physiopathology ; Matrix Metalloproteinase 9/genetics ; Rats ; Rats, Inbred SHR/genetics ; Rats, Inbred SHR/physiology ; Sedentary Behavior ; Transforming Growth Factor beta/genetics

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Skocz do pozycji: 17.

Tytuł:: Renoprotective effects of a dipeptidyl peptidase 4 inhibitor in a mouse model of progressive renal fibrosis.
Autorzy:: Uchida T; a Department of Nephrology and Endocrinology , National Defense Medical College , Tokorozawa , Saitama , Japan.
Oda T; b Department of Nephrology , Tokyo Medical University Hachioji Medical Center , Hachioji , Tokyo , Japan.
Matsubara H; a Department of Nephrology and Endocrinology , National Defense Medical College , Tokorozawa , Saitama , Japan.
Watanabe A; a Department of Nephrology and Endocrinology , National Defense Medical College , Tokorozawa , Saitama , Japan.
Takechi H; a Department of Nephrology and Endocrinology , National Defense Medical College , Tokorozawa , Saitama , Japan.
Oshima N; a Department of Nephrology and Endocrinology , National Defense Medical College , Tokorozawa , Saitama , Japan.
Sakurai Y; c Department of Preventive Medicine and Public Health , National Defense Medical College , Tokorozawa , Saitama , Japan.
Kumagai H; a Department of Nephrology and Endocrinology , National Defense Medical College , Tokorozawa , Saitama , Japan.; Pokaż więcej
Źródło:: Renal failure [Ren Fail] 2017 Nov; Vol. 39 (1), pp. 340-349.
Typ publikacji:: Journal Article
MeSH Terms:: Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use
Fibrosis/*drug therapy
Kidney/*drug effects
Piperidines/*therapeutic use
Renal Insufficiency, Chronic/*drug therapy
Uracil/*analogs & derivatives
Actins/metabolism ; Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Blood Urea Nitrogen ; Calcium-Binding Proteins ; Creatinine/blood ; Disease Models, Animal ; Fibrosis/metabolism ; Kidney/pathology ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Cell Surface/metabolism ; Receptors, G-Protein-Coupled ; Transforming Growth Factor beta/metabolism ; Uracil/therapeutic use ; Ureteral Obstruction/complications

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Skocz do pozycji: 18.

Tytuł:: TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases.
Autorzy:: Pardali E; Department of Cardiovascular Medicine, University of Münster, 48149 Münster, Germany. .
Sanchez-Duffhues G; Department of Molecular Cell Biology and Cancer Genomics Center Netherlands, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands. G.Sanchez_.
Gomez-Puerto MC; Department of Molecular Cell Biology and Cancer Genomics Center Netherlands, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands. M.C.Gomez_.
Ten Dijke P; Department of Molecular Cell Biology and Cancer Genomics Center Netherlands, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands. P.ten_.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2017 Oct 17; Vol. 18 (10). Date of Electronic Publication: 2017 Oct 17.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Epithelial-Mesenchymal Transition*
Fibrosis/*etiology
Fibrosis/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Biomarkers ; Cell Transdifferentiation ; Endothelial Cells/metabolism ; Extracellular Matrix/metabolism ; Fibroblasts/metabolism ; Fibrosis/diagnosis ; Humans ; Myofibroblasts/metabolism ; Signal Transduction

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Skocz do pozycji: 19.

Tytuł:: CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling.
Autorzy:: Rodríguez-Nieves JA; Center for Personalized Cancer Therapy and Department of Biology, University of Massachusetts, Boston, Massachusetts.
Patalano SC; Center for Personalized Cancer Therapy and Department of Biology, University of Massachusetts, Boston, Massachusetts.
Almanza D; Center for Personalized Cancer Therapy and Department of Biology, University of Massachusetts, Boston, Massachusetts.
Gharaee-Kermani M; Center for Personalized Cancer Therapy and Department of Biology, University of Massachusetts, Boston, Massachusetts.
Macoska JA; Center for Personalized Cancer Therapy and Department of Biology, University of Massachusetts, Boston, Massachusetts.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2016 Jul 19; Vol. 11 (7), pp. e0159490. Date of Electronic Publication: 2016 Jul 19 (Print Publication: 2016).
Typ publikacji:: Journal Article
MeSH Terms:: Chemokine CXCL12/*genetics
Fibrosis/*genetics
Prostatic Hyperplasia/*genetics
Receptors, CXCR4/*genetics
Cell Line, Tumor ; Chemokine CXCL12/biosynthesis ; ErbB Receptors/genetics ; Fibrosis/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Lower Urinary Tract Symptoms ; MAP Kinase Signaling System/genetics ; Male ; Myofibroblasts/pathology ; Prostate/pathology ; Prostatic Hyperplasia/pathology ; Protein Serine-Threonine Kinases/genetics ; Receptor, Transforming Growth Factor-beta Type I ; Receptors, CXCR4/biosynthesis ; Receptors, Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/genetics

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Skocz do pozycji: 20.

Tytuł:: Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis.
Autorzy:: Di Gregorio J; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Sferra R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Speca S; University of Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France.; IBD, Lille, France.
Vetuschi A; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Dubuquoy C; IBD, Lille, France.
Desreumaux P; University of Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France.; IBD, Lille, France.; CHR Lille, Service des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Claude Huriez, Lille, France.
Pompili S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Cristiano L; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Gaudio E; Department of Human Anatomy, University of Rome La Sapienza, Rome, Italy.
Flati V; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Latella G; Department of Life, Health and Environmental Sciences, Gastroenterology Unit, University of L'Aquila, L'Aquila, Italy.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Feb 16; Vol. 12 (2), pp. e0171093. Date of Electronic Publication: 2017 Feb 16 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Epithelial-Mesenchymal Transition*
Colitis/*pathology
Dextran Sulfate/*toxicity
Fibrosis/*pathology
Glycogen Synthase Kinase 3 beta/*metabolism
PPAR gamma/*metabolism
Rectum/*pathology
Animals ; Cells, Cultured ; Colitis/chemically induced ; Colitis/metabolism ; Fibrosis/chemically induced ; Fibrosis/metabolism ; Glycogen Synthase Kinase 3 beta/genetics ; Mice ; Mice, Inbred C57BL ; PPAR gamma/genetics ; Rectum/drug effects ; Rectum/metabolism ; Signal Transduction ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism

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