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Tytuł:
Controlling therapeutic protein expression via inhalation of a butter flavor molecule.
Autorzy:
Bertschi A; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Stefanov BA; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Xue S; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Charpin-El Hamri G; Département Génie Biologique, Institut Universitaire de Technologie, Université Claude Bernard, Lyon 1 Villeurbanne Cedex F-69622, France.
Teixeira AP; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Fussenegger M; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.; University of Basel, Faculty of Science, Mattenstrasse 26, CH-4058 Basel, Switzerland.
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Źródło:
Nucleic acids research [Nucleic Acids Res] 2023 Mar 21; Vol. 51 (5), pp. e28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetoin*/administration & dosage
Diabetes Mellitus, Experimental*/therapy
Transgenes*
Animals ; Mice ; Bacterial Proteins ; Base Sequence ; Transcription Factors/metabolism ; Administration, Inhalation
Czasopismo naukowe
Szczegóły
Tytuł:
Non-viral precision T cell receptor replacement for personalized cell therapy.
Autorzy:
Foy SP; PACT Pharma, South San Francisco, CA, USA. .
Jacoby K; PACT Pharma, South San Francisco, CA, USA.
Bota DA; Department of Neurology and Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA.
Hunter T; PACT Pharma, South San Francisco, CA, USA.
Pan Z; PACT Pharma, South San Francisco, CA, USA.
Stawiski E; PACT Pharma, South San Francisco, CA, USA.
Ma Y; PACT Pharma, South San Francisco, CA, USA.
Lu W; PACT Pharma, South San Francisco, CA, USA.
Peng S; PACT Pharma, South San Francisco, CA, USA.
Wang CL; PACT Pharma, South San Francisco, CA, USA.
Yuen B; PACT Pharma, South San Francisco, CA, USA.
Dalmas O; PACT Pharma, South San Francisco, CA, USA.
Heeringa K; PACT Pharma, South San Francisco, CA, USA.
Sennino B; PACT Pharma, South San Francisco, CA, USA.
Conroy A; PACT Pharma, South San Francisco, CA, USA.
Bethune MT; PACT Pharma, South San Francisco, CA, USA.
Mende I; PACT Pharma, South San Francisco, CA, USA.
White W; PACT Pharma, South San Francisco, CA, USA.
Kukreja M; PACT Pharma, South San Francisco, CA, USA.
Gunturu S; PACT Pharma, South San Francisco, CA, USA.
Humphrey E; PACT Pharma, South San Francisco, CA, USA.
Hussaini A; PACT Pharma, South San Francisco, CA, USA.
An D; PACT Pharma, South San Francisco, CA, USA.
Litterman AJ; PACT Pharma, South San Francisco, CA, USA.
Quach BB; PACT Pharma, South San Francisco, CA, USA.
Ng AHC; Institute for Systems Biology, Seattle, WA, USA.
Lu Y; Institute for Systems Biology, Seattle, WA, USA.
Smith C; PACT Pharma, South San Francisco, CA, USA.
Campbell KM; Department of Medicine, Division of Hematology-Oncology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Anaya D; PACT Pharma, South San Francisco, CA, USA.
Skrdlant L; PACT Pharma, South San Francisco, CA, USA.
Huang EY; PACT Pharma, South San Francisco, CA, USA.
Mendoza V; PACT Pharma, South San Francisco, CA, USA.
Mathur J; PACT Pharma, South San Francisco, CA, USA.
Dengler L; PACT Pharma, South San Francisco, CA, USA.
Purandare B; PACT Pharma, South San Francisco, CA, USA.
Moot R; PACT Pharma, South San Francisco, CA, USA.
Yi MC; PACT Pharma, South San Francisco, CA, USA.
Funke R; PACT Pharma, South San Francisco, CA, USA.
Sibley A; PACT Pharma, South San Francisco, CA, USA.
Stallings-Schmitt T; PACT Pharma, South San Francisco, CA, USA.
Oh DY; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA, USA.
Chmielowski B; Department of Medicine, Division of Hematology-Oncology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, CA, USA.
Abedi M; Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA.
Yuan Y; Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
Sosman JA; Department of Medicine and Robert H. Lurie Cancer Center, Northwestern University, Evanston, IL, USA.
Lee SM; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Schoenfeld AJ; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
Baltimore D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Heath JR; Institute for Systems Biology, Seattle, WA, USA.
Franzusoff A; PACT Pharma, South San Francisco, CA, USA.
Ribas A; Department of Medicine, Division of Hematology-Oncology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA. .; Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, CA, USA. .
Rao AV; PACT Pharma, South San Francisco, CA, USA.
Mandl SJ; PACT Pharma, South San Francisco, CA, USA. .
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Źródło:
Nature [Nature] 2023 Mar; Vol. 615 (7953), pp. 687-696. Date of Electronic Publication: 2022 Nov 10.
Typ publikacji:
Clinical Trial, Phase I; Journal Article
MeSH Terms:
Cell- and Tissue-Based Therapy*/adverse effects
Cell- and Tissue-Based Therapy*/methods
Gene Editing*
Neoplasms*/complications
Neoplasms*/genetics
Neoplasms*/immunology
Neoplasms*/therapy
Precision Medicine*/adverse effects
Precision Medicine*/methods
Receptors, Antigen, T-Cell*/genetics
Receptors, Antigen, T-Cell*/immunology
Receptors, Antigen, T-Cell*/metabolism
T-Lymphocytes*/immunology
T-Lymphocytes*/metabolism
Transgenes*/genetics
Humans ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Biopsy ; Cytokine Release Syndrome/complications ; Disease Progression ; Encephalitis/complications ; Gene Knock-In Techniques ; Gene Knockout Techniques ; Genes, T-Cell Receptor alpha ; Genes, T-Cell Receptor beta ; Mutation ; Patient Safety ; HLA Antigens/immunology ; CRISPR-Cas Systems
Czasopismo naukowe
Szczegóły
Tytuł:
Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors.
Autorzy:
Nousiainen A; A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Schenkwein D; A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Ylä-Herttuala S; A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.; Heart Center and Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.
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Źródło:
PloS one [PLoS One] 2023 Jan 20; Vol. 18 (1), pp. e0280894. Date of Electronic Publication: 2023 Jan 20 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Therapy*/methods
Genetic Vectors*/genetics
Lentivirus*/genetics
Transgenes*
Virus Integration*
Viral Fusion Proteins*
Humans ; Endonucleases/genetics ; Genes, rRNA ; RNA, Ribosomal, 28S
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Degron tagging of BleoR and other antibiotic-resistance genes selects for higher expression of linked transgenes and improved exosome engineering.
Autorzy:
Tsai SJ; Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
Ai Y; Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
Guo C; Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
Gould SJ; Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 May; Vol. 298 (5), pp. 101846. Date of Electronic Publication: 2022 Mar 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Anti-Bacterial Agents*/pharmacology
Drug Resistance*/genetics
Exosomes*/genetics
Transgenes*
Cell Line ; Humans ; Proteins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Sex separation by body color via a W-chromosome-linked transgene.
Autorzy:
Ye X; College of Animal Sciences, Zhejiang University, Hangzhou, PR China. Electronic address: .
Wu M; College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Wang X; College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Dai X; College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Yu S; College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Tang X; College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Wang X; College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Zhong B; College of Animal Sciences, Zhejiang University, Hangzhou, PR China. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2023 Apr 15; Vol. 234, pp. 123649. Date of Electronic Publication: 2023 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Bombyx*/genetics
Animals ; Male ; Female ; Animals, Genetically Modified/genetics ; Transgenes ; Promoter Regions, Genetic ; Phenotype ; Insecta/genetics ; Chromosomes
Czasopismo naukowe
Szczegóły
Tytuł:
A novel hybrid promoter capable of continuously producing proteins in high yield.
Autorzy:
Lee H; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Song ES; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Lee YH; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Park JY; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Kuk MU; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Kwon HW; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea; Convergence Research Center for Insect Vectors, Incheon National University, Incheon, 22012, South Korea.
Roh H; Department of Chemical and Biological Engineering, Inha Technical College, Incheon, 22212, South Korea. Electronic address: .
Park JT; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea; Convergence Research Center for Insect Vectors, Incheon National University, Incheon, 22012, South Korea. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Apr 02; Vol. 650, pp. 103-108. Date of Electronic Publication: 2023 Feb 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Vectors*
Zebrafish*
Animals ; Humans ; Promoter Regions, Genetic ; Transgenes ; Cell Line ; Simian virus 40/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Dual transgene amelioration of Lama2-null muscular dystrophy.
Autorzy:
McKee KK; Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.
Yurchenco PD; Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA. Electronic address: .
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Źródło:
Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2023 Apr; Vol. 118, pp. 1-15. Date of Electronic Publication: 2023 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Muscle, Skeletal*/metabolism
Muscular Dystrophies*/genetics
Muscular Dystrophies*/metabolism
Mice ; Animals ; Laminin/genetics ; Laminin/metabolism ; Mice, Transgenic ; Transgenes
Czasopismo naukowe
Szczegóły
Tytuł:
Local and systemic administration of AAV vectors with alphaherpesvirus latency-associated promoter 2 drives potent transgene expression in mouse liver, kidney, and skeletal muscle.
Autorzy:
Maturana CJ; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA. Electronic address: .
Chan A; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Verpeut JL; Department of Psychology, Arizona State University, Tempe, AZ 85287, USA.
Engel EA; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
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Źródło:
Journal of virological methods [J Virol Methods] 2023 Apr; Vol. 314, pp. 114688. Date of Electronic Publication: 2023 Feb 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Muscle, Skeletal*/metabolism
Liver*
Mice ; Animals ; Tissue Distribution ; Transgenes ; Kidney ; Genetic Vectors ; Dependovirus/genetics ; Transduction, Genetic
Czasopismo naukowe
Szczegóły
Tytuł:
Transgene insertion into the plastid genome alters expression of adjacent native chloroplast genes at the transcriptional and translational levels.
Autorzy:
Ghandour R; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Gao Y; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Laskowski J; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Barahimipour R; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Ruf S; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Bock R; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
Zoschke R; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2023 Apr; Vol. 21 (4), pp. 711-725. Date of Electronic Publication: 2023 Jan 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Chloroplast*
Genome, Chloroplast*/genetics
Transgenes ; Chloroplasts/genetics ; Transcription, Genetic ; Tobacco/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An efficient transformation method for tannin-containing sorghum.
Autorzy:
Liang Y; College of Agricultural, Anhui Science and Technology University, Fengyang, Anhui, China.
Yan X; College of Agricultural, Anhui Science and Technology University, Fengyang, Anhui, China.
Xu J; College of Agricultural, Anhui Science and Technology University, Fengyang, Anhui, China.
Liu Y; College of Agricultural, Anhui Science and Technology University, Fengyang, Anhui, China.
Xie K; Research Center of Biology and Agriculture, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Li J; College of Agricultural, Anhui Science and Technology University, Fengyang, Anhui, China.
Zhan Q; College of Agricultural, Anhui Science and Technology University, Fengyang, Anhui, China.
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Źródło:
PeerJ [PeerJ] 2023 Mar 14; Vol. 11, pp. e15066. Date of Electronic Publication: 2023 Mar 14 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Tannins*/metabolism
Sorghum*/genetics
Transformation, Genetic ; Transgenes ; Plants, Genetically Modified/genetics ; Edible Grain
Czasopismo naukowe
Szczegóły
Tytuł:
A toolkit for converting Gal4 into LexA and Flippase transgenes in Drosophila.
Autorzy:
Karuparti S; Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Yeung AT; Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Wang B; Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Guicardi PF; Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Han C; Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2023 Mar 09; Vol. 13 (3).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Drosophila*/genetics
Drosophila*/metabolism
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Animals ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transgenes ; Models, Biological ; Drosophila melanogaster/genetics ; Animals, Genetically Modified
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1.
Autorzy:
Hoang HD; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Said A; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Vaidya N; Department Immunology, University of Toronto, Toronto, Ontario, Canada.
Gilchrist VH; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Malone K; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Kabilan U; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Topshee S; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Xiang X; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Yang AD; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Olagnier D; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Mossman K; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Beug ST; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Jafarnejad SM; Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
Workenhe ST; Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.
Graber TE; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Alain T; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada .; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.; Centre for Infection, Immunity and Inflammation, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
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Źródło:
Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Mar; Vol. 11 (3).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Herpesvirus 1, Human*/genetics
Oncolytic Viruses*/genetics
Animals ; Mice ; Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Transgenes ; Protein Biosynthesis
Czasopismo naukowe
Szczegóły
Tytuł:
Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson's disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A).
Autorzy:
Gopurappilly R; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India. Electronic address: .
Musthafa T; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India.
Sukumaran S; Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru 560029, India.
Viswanath B; Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru 560029, India.
Hasan G; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India.
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Źródło:
Stem cell research [Stem Cell Res] 2023 Mar; Vol. 67, pp. 103033. Date of Electronic Publication: 2023 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/genetics
Induced Pluripotent Stem Cells*/metabolism
Parkinsonian Disorders*/genetics
Humans ; Mutation ; Transgenes ; Group VI Phospholipases A2/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
A novel hybrid seed production technology based on a unilateral cross-incompatibility gene in maize.
Autorzy:
Cai D; State Key Laboratory of Plant Cell and Chromosome Engineering, Innovative Academy of Seed Design, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100039, China.
Zhang Z; State Key Laboratory of Plant Cell and Chromosome Engineering, Innovative Academy of Seed Design, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Zhao L; State Key Laboratory of Plant Cell and Chromosome Engineering, Innovative Academy of Seed Design, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Liu J; State Key Laboratory of Plant Cell and Chromosome Engineering, Innovative Academy of Seed Design, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Chen H; State Key Laboratory of Plant Cell and Chromosome Engineering, Innovative Academy of Seed Design, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. .
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Źródło:
Science China. Life sciences [Sci China Life Sci] 2023 Mar; Vol. 66 (3), pp. 595-601. Date of Electronic Publication: 2022 Sep 30.
Typ publikacji:
Journal Article
MeSH Terms:
Zea mays*/metabolism
Plant Breeding*
Plants, Genetically Modified/genetics ; Transgenes ; Seeds/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
PI3K(p110α) as a determinant and gene therapy for atrial enlargement in atrial fibrillation.
Autorzy:
Ezeani M; NanoBiotechnology Laboratory, Central Clinical School, Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, 3004, Australia. .
Prabhu S; The Alfred, and Baker Heart and Diabetes Institute, Melbourne, Australia.; The University of Melbourne, Melbourne, Australia.
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Źródło:
Molecular and cellular biochemistry [Mol Cell Biochem] 2023 Mar; Vol. 478 (3), pp. 471-490. Date of Electronic Publication: 2022 Jul 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Atrial Fibrillation*/genetics
Atrial Fibrillation*/therapy
Genetic Therapy*
Phosphatidylinositol 3-Kinases*/genetics
Humans ; Animals ; Mice ; Transgenes ; Mice, Transgenic
Czasopismo naukowe
Szczegóły
Tytuł:
A Ubiquitous Chromatin Opening Element and DNA Demethylation Facilitate Doxycycline-Controlled Expression during Differentiation and in Transgenic Mice.
Autorzy:
Gödecke N; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Herrmann S; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Weichelt V; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Wirth D; RG Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.; Institute of Experimental Hematology, Medical University Hannover (MHH), 30625 Hannover, Germany.
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Źródło:
ACS synthetic biology [ACS Synth Biol] 2023 Feb 17; Vol. 12 (2), pp. 482-491. Date of Electronic Publication: 2023 Feb 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromatin*
Doxycycline*/pharmacology
Mice ; Animals ; Mice, Transgenic ; DNA Demethylation ; Transgenes/genetics ; Cell Differentiation/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
The CRISPR-Cas12a Platform for Accurate Genome Editing, Gene Disruption, and Efficient Transgene Integration in Human Immune Cells.
Autorzy:
Mohr M; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Damas N; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Gudmand-Høyer J; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Zeeberg K; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Jedrzejczyk D; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Vlassis A; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Morera-Gómez M; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Pereira-Schoning S; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, Colorado 80027, United States.
Puš U; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Oliver-Almirall A; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Lyholm Jensen T; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Baumgartner R; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, Colorado 80027, United States.
Tate Weinert B; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.
Gill RT; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, Colorado 80027, United States.
Warnecke T; Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, Colorado 80027, United States.
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Źródło:
ACS synthetic biology [ACS Synth Biol] 2023 Feb 17; Vol. 12 (2), pp. 375-389. Date of Electronic Publication: 2023 Feb 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Editing*/methods
CRISPR-Cas Systems*/genetics
Humans ; Transgenes/genetics ; Endonucleases/genetics ; DNA End-Joining Repair
Czasopismo naukowe
Szczegóły
Tytuł:
Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads.
Autorzy:
Blanch-Asensio A; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands.
van der Vaart B; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; LUMC hiPSC Hotel, Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands.
Vinagre M; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands.
Groen E; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands.
Arendzen C; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; LUMC hiPSC Hotel, Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands.
Freund C; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; LUMC hiPSC Hotel, Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands.
Geijsen N; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands.
Mummery CL; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands; Department of Applied Stem Cell Technologies, University of Twente, 7500AE Enschede, the Netherlands.
Davis RP; Department of Anatomy and Embryology, Leiden University Medical Center, 2300RC Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, 2300RC Leiden, the Netherlands. Electronic address: .
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Źródło:
Stem cell research [Stem Cell Res] 2023 Feb; Vol. 66, pp. 102991. Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Induced Pluripotent Stem Cells*
Humans ; DNA/genetics ; Transgenes
Czasopismo naukowe
Szczegóły
Tytuł:
Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii.
Autorzy:
Pollegioni P; Research Institute on Terrestrial Ecosystems, National Research Council, Terni, Italy.; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Persampieri T; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Minuz RL; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Bucci A; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Trusso A; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Martino SD; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Leo C; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Bruttini M; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.; Tuscan Centre of Precision Medicine, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Ciolfi M; Research Institute on Terrestrial Ecosystems, National Research Council, Terni, Italy.
Waldvogel AM; Institute of Zoology, University of Cologne, Köln, Germany.
Tripet F; Centre for Applied Entomology and Parasitology, Keele University, Newcastle-under-Lyme, UK.
Simoni A; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Crisanti A; Department of Molecular Medicine, University of Padova, Padova, Italy.
Müller R; Genetics and Ecology Research Centre, Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.; Unit Entomology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
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Źródło:
Insect molecular biology [Insect Mol Biol] 2023 Feb; Vol. 32 (1), pp. 56-68. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anopheles*/genetics
Female ; Animals ; Male ; Sex Ratio ; Mosquito Vectors/genetics ; Semen ; Transgenes
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 21255

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