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Tytuł :
Differential interactions of carbamate pesticides with drug transporters.
Autorzy :
Guéniche N; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.; ANSES (French Agency for Food, Environmental and Occupational Health and Safety), Fougères Laboratory, Toxicology of Contaminant Unit, Fougères, France.
Bruyere A; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Ringeval M; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Jouan E; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.
Huguet A; ANSES (French Agency for Food, Environmental and Occupational Health and Safety), Fougères Laboratory, Toxicology of Contaminant Unit, Fougères, France.
Le Hégarat L; ANSES (French Agency for Food, Environmental and Occupational Health and Safety), Fougères Laboratory, Toxicology of Contaminant Unit, Fougères, France.
Fardel O; Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085, Rennes, France.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Nov; Vol. 50 (11), pp. 1380-1392. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Transport*
ATP-Binding Cassette Transporters/*metabolism
Carbamates/*metabolism
Pesticides/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Drug Interactions ; Humans ; Insecticides ; Neoplasm Proteins ; Organic Cation Transport Proteins
Czasopismo naukowe
Tytuł :
Structural basis of ion transport and inhibition in ferroportin.
Autorzy :
Pan Y; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA. .
Ren Z; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Gao S; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA. .
Shen J; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Wang L; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Xu Z; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Yu Y; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Bachina P; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Zhang H; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Fan X; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Laganowsky A; Department of Chemistry, Texas A & M University, College Station, TX, 77843, USA.
Yan N; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Zhou M; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 10; Vol. 11 (1), pp. 5686. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cryoelectron Microscopy*
Cation Transport Proteins/*ultrastructure
Hepcidins/*metabolism
Iron/*metabolism
Anemia, Iron-Deficiency ; Animals ; Binding Sites ; Cation Transport Proteins/chemistry ; Cation Transport Proteins/metabolism ; Humans ; Ion Transport ; Protein Binding
Czasopismo naukowe
Tytuł :
The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity.
Autorzy :
Kreimendahl S; Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
Rassow J; Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 01; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Immunity, Innate*
Mitochondrial Membrane Transport Proteins/*chemistry
Animals ; Betacoronavirus/genetics ; Binding Sites ; Humans ; Mitochondrial Membrane Transport Proteins/metabolism ; Open Reading Frames ; Protein Binding ; Protein Transport
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
Regulation of mRNA export through API5 and nuclear FGF2 interaction.
Autorzy :
Bong SM; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.
Bae SH; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi 10408, Republic of Korea.
Song B; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.
Gwak H; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.
Yang SW; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.
Kim S; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.
Nam S; Department of Life Sciences, College of BioNano Technology and Department of Genome Medicine and Science, Graduate School of Medicine, Gachon University, Incheon 21565, Republic of Korea.
Rajalingam K; Cell Biology Unit, University Medical Center Mainz, JGU, Mainz, Germany.
Oh SJ; Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Republic of Korea.
Kim TW; Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Republic of Korea.
Park S; School of Systems Biomedical Science, Soongsil University, Seoul 06978, Republic of Korea.
Jang H; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi 10408, Republic of Korea.
Lee BI; Research Institute, National Cancer Center, Goyang-si, Gyeonggi 10408, Republic of Korea.; Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi 10408, Republic of Korea.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 19; Vol. 48 (11), pp. 6340-6352.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Transport*
Apoptosis Regulatory Proteins/*chemistry
Apoptosis Regulatory Proteins/*metabolism
Fibroblast Growth Factor 2/*chemistry
Fibroblast Growth Factor 2/*metabolism
Nuclear Proteins/*chemistry
Nuclear Proteins/*metabolism
RNA, Messenger/*metabolism
Active Transport, Cell Nucleus ; Cell Nucleus/metabolism ; Crystallography, X-Ray ; Cyclin D1/metabolism ; DEAD-box RNA Helicases/metabolism ; Eukaryotic Initiation Factor-4E/metabolism ; Humans ; Models, Molecular ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins c-myc/metabolism
Czasopismo naukowe
Tytuł :
Effects of external Mn activities on OsNRAMP5 expression level and Cd accumulation in indica rice.
Autorzy :
Cai Y; State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Wang M; State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
Chen B; State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
Chen W; State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: .
Xu W; Jiangxi Super-rice Research and Development Center, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China.
Xie H; Jiangxi Super-rice Research and Development Center, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China.
Long Q; Jiangxi Super-rice Research and Development Center, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China.
Cai Y; Jiangxi Super-rice Research and Development Center, Jiangxi Academy of Agricultural Sciences, Nanchang, 330200, China.
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2020 May; Vol. 260, pp. 113941. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Cadmium*/metabolism
Gene Expression Regulation, Plant*/drug effects
Membrane Transport Proteins*/genetics
Oryza*/drug effects
Biological Transport/drug effects ; Manganese/toxicity ; Plant Roots/drug effects
Czasopismo naukowe
Tytuł :
Retro Is Cool: Structure of the Versatile Retromer Complex.
Autorzy :
Martínez-Núñez L; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Munson M; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. Electronic address: .
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Źródło :
Structure (London, England : 1993) [Structure] 2020 Apr 07; Vol. 28 (4), pp. 387-389.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Endosomes*
Vesicular Transport Proteins*
Animals ; Membrane Proteins ; Protein Transport
Czasopismo naukowe
Tytuł :
Protein transmission in neurodegenerative disease.
Autorzy :
Peng C; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Trojanowski JQ; The Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Lee VM; The Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature reviews. Neurology [Nat Rev Neurol] 2020 Apr; Vol. 16 (4), pp. 199-212. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Protein Transport*
Brain/*metabolism
Neurodegenerative Diseases/*metabolism
Protein Aggregation, Pathological/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Axonal Transport ; Brain/pathology ; Cell Communication ; DNA-Binding Proteins/metabolism ; Endocytosis ; Exosomes/metabolism ; Genetic Predisposition to Disease ; Humans ; Huntingtin Protein/metabolism ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Membrane Fusion ; Nanotubes ; Neurodegenerative Diseases/pathology ; Neuroglia/metabolism ; Neurons/metabolism ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Protein Aggregation, Pathological/pathology ; alpha-Synuclein/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Evaluation of mtr cluster expression in Shewanella RCRI7 during uranium removal.
Autorzy :
Ghasemi R; Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
Fatemi F; Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran. .
Mir-Derikvand M; Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran. .
Zarei M; Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
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Źródło :
Archives of microbiology [Arch Microbiol] 2020 Dec; Vol. 202 (10), pp. 2711-2726. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Biodegradation, Environmental*
Membrane Transport Proteins/*genetics
Shewanella/*genetics
Shewanella/*metabolism
Uranium/*analysis
Water Pollutants, Chemical/*analysis
Bacterial Outer Membrane Proteins/genetics ; Cytochrome c Group/genetics ; Electron Transport/genetics ; Multigene Family/genetics ; Oxidation-Reduction ; Waste Water/chemistry ; Water Pollution/analysis
Czasopismo naukowe
Tytuł :
pH dependence of the Slc4a11-mediated H conductance is influenced by intracellular lysine residues and modified by disease-linked mutations.
Autorzy :
Quade BN; Department of Physiology and Biophysics, The State University of New York: The University at Buffalo, Buffalo, New York.
Marshall A; Department of Physiology and Biophysics, The State University of New York: The University at Buffalo, Buffalo, New York.
Parker MD; Department of Physiology and Biophysics, The State University of New York: The University at Buffalo, Buffalo, New York.; Department of Ophthalmology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo: The State University of New York, Buffalo, New York.; State University of New York Eye Institute, University at Buffalo: The State University of New York, Buffalo, New York.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Aug 01; Vol. 319 (2), pp. C359-C370. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anion Transport Proteins/*genetics
Biological Transport/*genetics
Corneal Dystrophies, Hereditary/*genetics
Lysine/*genetics
Symporters/*genetics
Animals ; Animals, Genetically Modified/genetics ; Animals, Genetically Modified/metabolism ; Bicarbonates/metabolism ; Corneal Dystrophies, Hereditary/metabolism ; Corneal Dystrophies, Hereditary/pathology ; Disease Models, Animal ; Endothelium, Corneal/metabolism ; Endothelium, Corneal/pathology ; Gene Expression Regulation/genetics ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Ion Transport/genetics ; Lysine/metabolism ; Mice ; Mutation/genetics ; Oocytes/metabolism ; Oocytes/pathology ; Sodium ; Xenopus/genetics
Czasopismo naukowe
Tytuł :
Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction.
Autorzy :
Pendleton AL; Physiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.
Antolic AT; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Kelly AC; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Davis MA; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Camacho LE; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Doubleday K; Department of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, Arizona.
Anderson MJ; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
Langlais PR; Physiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.; Department of Medicine, University of Arizona, Tucson, Arizona.
Lynch RM; Physiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.; Department of Physiology, University of Arizona, Tucson, Arizona.
Limesand SW; Physiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona.; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Jul 01; Vol. 319 (1), pp. E67-E80. Date of Electronic Publication: 2020 May 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Citric Acid Cycle/*physiology
Electron Transport Complex I/*metabolism
Fetal Growth Retardation/*metabolism
Mitochondria, Muscle/*metabolism
Animals ; Down-Regulation ; Electron Transport Complex II/metabolism ; Electron Transport Complex IV/metabolism ; Female ; Fetal Growth Retardation/enzymology ; Hamstring Muscles/enzymology ; Hamstring Muscles/metabolism ; Hypoglycemia/enzymology ; Hypoglycemia/metabolism ; Hypoxia/enzymology ; Hypoxia/metabolism ; Isocitrate Dehydrogenase/metabolism ; Ketoglutarate Dehydrogenase Complex/metabolism ; Mitochondria, Muscle/enzymology ; Mitochondrial Proteins/metabolism ; Muscle, Skeletal/enzymology ; Muscle, Skeletal/metabolism ; Oxygen Consumption ; Placental Insufficiency/enzymology ; Placental Insufficiency/metabolism ; Pregnancy ; Proteomics ; Sheep ; Succinate-CoA Ligases/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme.
Autorzy :
Li Y; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Ivica NA; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Dong T; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Papageorgiou DP; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
He Y; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Brown DR; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Kleyman M; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Hu G; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Chen WW; Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.; Boston Combined Residency Program, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Sullivan LB; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Del Rosario A; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Hammond PT; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Vander Heiden MG; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Dana-Farber Cancer Institute, Boston, MA, 02115, USA.
Chen J; Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 24; Vol. 11 (1), pp. 4837. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Heme/*metabolism
Membrane Transport Proteins/*metabolism
Mitochondria/*metabolism
Receptors, Virus/*metabolism
Thermogenesis/*physiology
Animals ; Cytochrome-c Oxidase Deficiency ; Electron Transport Complex III ; Electron Transport Complex IV ; Energy Metabolism/physiology ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Membrane Transport Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondrial Membranes/metabolism ; Protein Domains ; Receptors, Virus/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Signal Transduction ; THP-1 Cells
Czasopismo naukowe
Tytuł :
The natural function of the malaria parasite's chloroquine resistance transporter.
Autorzy :
Shafik SH; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia.
Cobbold SA; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, 3052, Australia.
Barkat K; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia.
Richards SN; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia.
Lancaster NS; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia.
Llinás M; Department of Biochemistry and Molecular Biology, Department of Chemistry, and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, 16802, USA.
Hogg SJ; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia.
Summers RL; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia.
McConville MJ; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, 3052, Australia.
Martin RE; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 06; Vol. 11 (1), pp. 3922. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimalarials/*pharmacology
Chloroquine/*pharmacology
Membrane Transport Proteins/*metabolism
Plasmodium falciparum/*drug effects
Plasmodium falciparum/*metabolism
Protozoan Proteins/*metabolism
Animals ; Biological Transport, Active ; Drug Resistance/genetics ; Female ; Host-Parasite Interactions/genetics ; Host-Parasite Interactions/physiology ; Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/metabolism ; Malaria, Falciparum/parasitology ; Membrane Transport Proteins/genetics ; Models, Biological ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Oligopeptides/metabolism ; Oocytes/metabolism ; Plasmodium falciparum/genetics ; Protein Transport ; Protozoan Proteins/genetics ; Xenopus laevis
Czasopismo naukowe
Tytuł :
[ H]Dopamine Uptake through the Dopamine and Norepinephrine Transporters is Decreased in the Prefrontal Cortex of Transgenic Mice Expressing HIV-1 Transactivator of Transcription Protein.
Autorzy :
Strauss M; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
O'Donovan B; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
Ma Y; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
Xiao Z; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
Lin S; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
Bardo MT; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
Ortinski PI; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
McLaughlin JP; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.).
Zhu J; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy (M.S., Y.M., Z.X., S.L., J.Z.) and Department of Physiology, Pharmacology and Neuroscience, School of Medicine (B.O.), University of South Carolina, Columbia, South Carolina; Departments of Psychology (M.B.) and Neuroscience (P.O.), University of Kentucky, Lexington, Kentucky; and Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida (J.M.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Aug; Vol. 374 (2), pp. 241-251. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dopamine/*metabolism
Dopamine Plasma Membrane Transport Proteins/*metabolism
Norepinephrine Plasma Membrane Transport Proteins/*metabolism
Prefrontal Cortex/*metabolism
tat Gene Products, Human Immunodeficiency Virus/*genetics
Animals ; Biological Transport ; Gene Expression ; Male ; Mice ; Mice, Transgenic ; Neurons/metabolism ; Prefrontal Cortex/cytology
Czasopismo naukowe
Tytuł :
Contacting domains segregate a lipid transporter from a solute transporter in the malarial host-parasite interface.
Autorzy :
Garten M; Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Beck JR; Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.
Roth R; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Tenkova-Heuser T; Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Heuser J; Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Istvan ES; Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Bleck CKE; Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Goldberg DE; Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. .
Zimmerberg J; Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 30; Vol. 11 (1), pp. 3825. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Lipids*
Malaria, Falciparum/*metabolism
Membrane Transport Proteins/*metabolism
Plasmodium falciparum/*metabolism
Protozoan Proteins/*metabolism
Biological Transport ; Cell Membrane/metabolism ; Cytoplasm/metabolism ; Cytoplasm/parasitology ; Erythrocytes/metabolism ; Erythrocytes/parasitology ; Host-Parasite Interactions ; Humans ; Intracellular Membranes/metabolism ; Intracellular Membranes/parasitology ; Malaria, Falciparum/parasitology ; Plasmodium falciparum/physiology ; Protein Transport ; Vacuoles/metabolism ; Vacuoles/parasitology
Czasopismo naukowe
Tytuł :
Gene Architecture and Sequence Composition Underpin Selective Dependency of Nuclear Export of Long RNAs on NXF1 and the TREX Complex.
Autorzy :
Zuckerman B; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Ron M; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
Mikl M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel.
Segal E; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel.
Ulitsky I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jul 16; Vol. 79 (2), pp. 251-267.e6. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Active Transport, Cell Nucleus*
RNA Transport*
Multiprotein Complexes/*metabolism
Nucleocytoplasmic Transport Proteins/*physiology
RNA/*metabolism
RNA-Binding Proteins/*physiology
Animals ; Base Sequence ; Cell Line ; Cell Nucleus/metabolism ; Humans ; Mice ; RNA/chemistry ; RNA Stability ; RNA-Seq
Czasopismo naukowe
Tytuł :
A kinetic mechanism for enhanced selectivity of membrane transport.
Autorzy :
Bisignano P; Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.
Lee MA; Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.
George A; Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, United States of America.
Zuckerman DM; Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, United States of America.
Grabe M; Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.
Rosenberg JM; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Jul 02; Vol. 16 (7), pp. e1007789. Date of Electronic Publication: 2020 Jul 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Binding Sites*
Membrane Transport Proteins*/chemistry
Membrane Transport Proteins*/metabolism
Models, Biological*
Biological Transport/*physiology
Protein Binding/*physiology
Computational Biology ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Sodium-Glucose Transporter 1 ; Substrate Specificity
Czasopismo naukowe
Tytuł :
ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic.
Autorzy :
Connell JW; Department of Medical Genetics and Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.; Alzheimer's Research, Cambridge, UK.
Allison RJ; Department of Medical Genetics and Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.
Rodger CE; Department of Medical Genetics and Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.
Pearson G; Department of Medical Genetics and Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.
Zlamalova E; Department of Medical Genetics and Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK.
Reid E; Department of Medical Genetics and Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Jul; Vol. 77 (13), pp. 2641-2658. Date of Electronic Publication: 2019 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Surface Extensions/*metabolism
Endosomal Sorting Complexes Required for Transport/*metabolism
Spastin/*metabolism
Animals ; Bone Morphogenetic Protein Receptors/metabolism ; Cell Membrane/metabolism ; Cell Polarity ; Cell Surface Extensions/ultrastructure ; Cells, Cultured ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Knock-In Techniques ; HeLa Cells ; Humans ; Kinesin/physiology ; Mice ; Protein Transport ; Spastic Paraplegia, Hereditary/genetics ; Spastin/genetics ; Vesicular Transport Proteins/physiology
Czasopismo naukowe
Tytuł :
Localization of aquaporin-3 proteins in the bovine rumen.
Autorzy :
Zhong C; School of Biology and Environmental Science, Science Centre West, University College Dublin, Belfield, Dublin 4, Ireland.
Farrell A; School of Biology and Environmental Science, Science Centre West, University College Dublin, Belfield, Dublin 4, Ireland.
Stewart GS; School of Biology and Environmental Science, Science Centre West, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: .
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Źródło :
Journal of dairy science [J Dairy Sci] 2020 Mar; Vol. 103 (3), pp. 2814-2820. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Transport*
Aquaporin 3/*metabolism
Cattle/*physiology
Membrane Transport Proteins/*metabolism
Nitrogen/*metabolism
Animals ; Aquaporin 3/genetics ; Cell Membrane/metabolism ; Epithelium/metabolism ; Female ; Membrane Transport Proteins/genetics ; Rumen/metabolism
Czasopismo naukowe
Tytuł :
Mechanisms of glutathione-conjugate efflux from the brain into blood: Involvement of multiple transporters in the course.
Autorzy :
Okamura T; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Okada M; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Kikuchi T; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Wakizaka H; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Zhang MR; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2020 Jan; Vol. 40 (1), pp. 116-125. Date of Electronic Publication: 2018 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Membrane Transport Proteins*/metabolism
Membrane Transport Proteins*/pharmacokinetics
Glutathione/*metabolism
Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Humans ; Mice ; Mice, Knockout ; Microinjections ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Multidrug Resistance-Associated Proteins/pharmacokinetics ; Organic Anion Transporters, Sodium-Independent/metabolism
Czasopismo naukowe
Tytuł :
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity.
Autorzy :
Debruycker V; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.
Hutchin A; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.
Masureel M; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA.
Ficici E; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Martens C; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium.
Legrand P; Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin 91192, Gif sur Yvette, France.
Stein RA; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.
Mchaourab HS; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.
Faraldo-Gómez JD; Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Remaut H; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; Structural and Molecular Microbiology, VIB-VUB Center for Structural Biology, Brussels, Belgium.
Govaerts C; Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Sep; Vol. 27 (9), pp. 829-835. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*metabolism
Bacterial Proteins/*metabolism
Lactococcus lactis/*metabolism
Membrane Transport Proteins/*metabolism
Phosphatidylglycerols/*metabolism
Bacterial Proteins/chemistry ; Binding Sites ; Biological Transport ; Crystallography, X-Ray ; Lactococcus lactis/chemistry ; Ligands ; Membrane Transport Proteins/chemistry ; Molecular Dynamics Simulation ; Phosphatidylglycerols/chemistry ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe

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