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Tytuł :
The Negative Allosteric Modulator EU1794-4 Reduces Single Channel Conductance and Ca Permeability of GluN1/GluN2A NMDA Receptors .
Autorzy :
Perszyk RE; Department of Pharmacology and Chemical Biology, Emory University, United States.
Zheng Z; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, United States of America.
Banke TG; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, United States of America.
Zhang J; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, United States of America.
Xie L; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, United States of America.
McDaniel MJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, United States of America.
Katzman BM; Chemistry, Emory University, United States of America.
Pelly SC; Chemistry, Emory University, United States of America.
Yuan H; Pharmacology, Emory University School of Medicine, United States of America.
Liotta DC; Chemistry, Emory University, United States of America.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, United States of America .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2021 Mar 09. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N -Methyl-d-aspartate Receptors.
Autorzy :
Strong KL; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Epplin MP; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Ogden KK; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Burger PB; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Kaiser TM; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Wilding TJ; Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63110, United States.
Kusumoto H; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Camp CR; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Shaulsky G; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Bhattacharya S; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama 36849, United States.
Perszyk RE; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Menaldino DS; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
McDaniel MJ; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Zhang J; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Le P; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Banke TG; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Hansen KB; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.; Center for Biomolecular Structure and Dynamics, Center for Structural and Functional Neuroscience, Division for Biological Sciences, University of Montana, 32 Campus Drive, Missoula, Montana 59812, United States.
Huettner JE; Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63110, United States.
Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Traynelis SF; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jan 06; Vol. 12 (1), pp. 79-98. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.
Autorzy :
Tang W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Liu D; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Oct 15; Vol. 177, pp. 108247. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Negative allosteric modulation of GluN1/GluN3 NMDA receptors.
Autorzy :
Zhu Z; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA; Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, Shaanxi, China.
Yi F; Center for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT, 59812, USA.
Epplin MP; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Liu D; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Summer SL; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Mizu R; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Shaulsky G; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
XiangWei W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Tang W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Burger PB; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Menaldino DS; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Myers SJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Liotta DC; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Hansen KB; Center for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT, 59812, USA.
Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2020 Oct 01; Vol. 176, pp. 108117. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif.
Autorzy :
Perszyk RE; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Myers SJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
Gibb AJ; Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Furukawa H; WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, 11724, USA.
Sobolevsky AI; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
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Źródło :
The Journal of physiology [J Physiol] 2020 Aug; Vol. 598 (15), pp. 3071-3083. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Awards and Prizes*
Ligand-Gated Ion Channels*
Biophysical Phenomena ; Glutamic Acid ; Humans ; Receptors, Glutamate
Czasopismo naukowe
Tytuł :
Discovery of Dihydropyrrolo[1,2- a ]pyrazin-3(4 H )-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N -Methyl-d-Aspartate (NMDA) Receptor.
Autorzy :
Epplin MP; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Mohan A; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Harris LD; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Zhu Z; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Strong KL; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Bacsa J; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Le P; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Menaldino DS; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7569-7600. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Pyrazines/*pharmacology
Pyrroles/*pharmacology
Receptors, N-Methyl-D-Aspartate/*agonists
Allosteric Regulation ; Animals ; Drug Design ; Isoquinolines/chemical synthesis ; Isoquinolines/pharmacology ; Male ; Mice, Inbred C57BL ; Molecular Structure ; Pyrazines/chemical synthesis ; Pyrazines/pharmacokinetics ; Pyrroles/chemical synthesis ; Pyrroles/pharmacokinetics ; Structure-Activity Relationship ; Xenopus laevis
Czasopismo naukowe
Tytuł :
The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus.
Autorzy :
Piard J; Centre de Génétique Humaine, Université de Franche-Comté, CHU, Besançon, France.; Unité de recherche en neurosciences intégratives et cognitives EA481, Université de Franche-Comté, Besançon, France.
Béreau M; Unité de recherche en neurosciences intégratives et cognitives EA481, Université de Franche-Comté, Besançon, France.; Service de Neurologie, CHU, Besançon, France.
XiangWei W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Wirth T; Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Amsallem D; Service de Neuropédiatrie, CHU, Besançon, France.
Buisson L; Service de Neuropédiatrie, CHU, Besançon, France.
Richard P; Service de Neurologie, CHU, Besançon, France.
Liu N; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Xu Y; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Myers SJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Functional Evaluation of Rare Variants, Emory University School of Medicine, Atlanta, Georgia, USA.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Functional Evaluation of Rare Variants, Emory University School of Medicine, Atlanta, Georgia, USA.
Chelly J; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Anheim M; Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
Raynaud M; CHRU de Tours, Service de Génétique, Tours, France.; UMR1253, iBrain, Université de Tours, Inserm, Tours, France.
Maldergem LV; Centre de Génétique Humaine, Université de Franche-Comté, CHU, Besançon, France.; Unité de recherche en neurosciences intégratives et cognitives EA481, Université de Franche-Comté, Besançon, France.; Clinical Investigation Center 1431, National Institute of Health and Medical Research, Besançon, France.
Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Functional Evaluation of Rare Variants, Emory University School of Medicine, Atlanta, Georgia, USA.
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Źródło :
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2020 Jul; Vol. 35 (7), pp. 1224-1232. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice.
Autorzy :
Amador A; Institute for Genomic Medicine, Columbia University, New York, NY, USA.
Bostick CD; Institute for Genomic Medicine, Columbia University, New York, NY, USA.
Olson H; Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Peters J; Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Camp CR; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.
Krizay D; Institute for Genomic Medicine, Columbia University, New York, NY, USA.; Department of Genetics and Development, Columbia University, New York, NY, USA.
Chen W; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410013, China.
Han W; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.; Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Tang W; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410013, China.
Kanber A; Institute for Genomic Medicine, Columbia University, New York, NY, USA.
Kim S; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.
Teoh J; Institute for Genomic Medicine, Columbia University, New York, NY, USA.
Sah M; Institute for Genomic Medicine, Columbia University, New York, NY, USA.
Petri S; Institute for Genomic Medicine, Columbia University, New York, NY, USA.
Paek H; Department of Otolaryngology and Head and Neck Surgery, Columbia University, New York, NY, USA.
Kim A; Department of Otolaryngology and Head and Neck Surgery, Columbia University, New York, NY, USA.
Lutz CM; Department of Otolaryngology and Head and Neck Surgery, Columbia University, New York, NY, USA.
Yang M; Institute for Genomic Medicine, Columbia University, New York, NY, USA.; Department of Psychiatry, Columbia University, New York, NY, USA.
Myers SJ; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
Bhattacharya S; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.
Yuan H; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
Goldstein DB; Institute for Genomic Medicine, Columbia University, New York, NY, USA.; Department of Genetics and Development, Columbia University, New York, NY, USA.
Poduri A; Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Boland MJ; Institute for Genomic Medicine, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
Frankel WN; Institute for Genomic Medicine, Columbia University, New York, NY, USA.; Department of Genetics and Development, Columbia University, New York, NY, USA.
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Źródło :
Brain : a journal of neurology [Brain] 2020 Jul 01; Vol. 143 (7), pp. 2039-2057.
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Epilepsy, Generalized/*drug therapy
Epilepsy, Generalized/*genetics
Excitatory Amino Acid Antagonists/*therapeutic use
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Dextromethorphan/therapeutic use ; Epilepsy, Generalized/pathology ; Gene Knock-In Techniques ; Humans ; Infant ; Male ; Memantine/therapeutic use ; Mice ; Neurodevelopmental Disorders/genetics ; Neurodevelopmental Disorders/pathology
Czasopismo naukowe
Tytuł :
NMDA receptor channel gating control by the pre-M1 helix.
Autorzy :
McDaniel MJ; Department of Pharmacology, Rollins Research Center, Emory University, Atlanta, GA.
Ogden KK; Department of Pharmacology, Rollins Research Center, Emory University, Atlanta, GA.
Kell SA; Department of Pharmacology, Rollins Research Center, Emory University, Atlanta, GA.; Department of Chemistry, Emory University, Atlanta, GA.
Burger PB; Department of Chemistry, Emory University, Atlanta, GA.
Liotta DC; Department of Chemistry, Emory University, Atlanta, GA.
Traynelis SF; Department of Pharmacology, Rollins Research Center, Emory University, Atlanta, GA.
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Źródło :
The Journal of general physiology [J Gen Physiol] 2020 Apr 06; Vol. 152 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
Czasopismo naukowe
Tytuł :
Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.
Autorzy :
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Dlugos D; Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Henshall D; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
Mefford HC; Department of Pediatrics, University of Washington, Seattle, WA, USA.
Rogawski MA; Departments of Neurology and Pharmacology, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Staley KJ; Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Dacks PA; American Epilepsy Society, Chicago, IL, USA.
Whittemore V; Division of Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MA, USA.
Poduri A; Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
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Corporate Authors :
National Institutes of Neurological Disorders and Stroke (NINDS)/American Epilepsy Society (AES) Epilepsy Research Benchmark Stewards
Źródło :
Epilepsy currents [Epilepsy Curr] 2020 Jan-Feb; Vol. 20 (1_suppl), pp. 23S-30S. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases.
Autorzy :
Li J; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Zhang J; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Tang W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Mizu RK; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Kusumoto H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
XiangWei W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Xu Y; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Amin JB; Department of Neurobiology & Behavior, Stony Brook University School of Medicine, Stony Brook, New York.
Hu C; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Kannan V; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Keller SR; Division of Pediatric Neurology, Emory University School of Medicine, Atlanta, Georgia.
Wilcox WR; Division of Medical Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia.
Lemke JR; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, Germany.
Myers SJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, Georgia.
Swanger SA; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Wollmuth LP; Department of Neurobiology & Behavior, Stony Brook University School of Medicine, Stony Brook, New York.
Petrovski S; Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, VIC, Australia.; Centre for Genomics Research, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, Georgia.
Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, Georgia.
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Źródło :
Human mutation [Hum Mutat] 2019 Dec; Vol. 40 (12), pp. 2393-2413. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation, Missense*
Nerve Tissue Proteins/*genetics
Nervous System Diseases/*genetics
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Child ; Disease Models, Animal ; Female ; HEK293 Cells ; Humans ; Male ; Models, Molecular ; Nerve Tissue Proteins/chemistry ; Phenotype ; Protein Conformation ; Receptors, N-Methyl-D-Aspartate/chemistry ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Distinct roles of GRIN2A and GRIN2B variants in neurological conditions.
Autorzy :
Myers SJ; Center for Functional Evaluation of Rare Variants (CFERV), Emory University, Atlanta, GA, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.
Yuan H; Center for Functional Evaluation of Rare Variants (CFERV), Emory University, Atlanta, GA, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.
Kang JQ; Department of Neurology, Vanderbilt Brain Institute, Vanderbilt Kennedy Center of Human Development, Vanderbilt University, Nashville, TN, USA.
Tan FCK; Department of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Traynelis SF; Center for Functional Evaluation of Rare Variants (CFERV), Emory University, Atlanta, GA, USA.; Department of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, USA.
Low CM; Department of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
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Źródło :
F1000Research [F1000Res] 2019 Nov 20; Vol. 8. Date of Electronic Publication: 2019 Nov 20 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Epilepsy*
Neurodevelopmental Disorders*/genetics
Receptors, N-Methyl-D-Aspartate*/genetics
Schizophrenia*
Mental Disorders/*genetics
Humans ; Phenotype
Czasopismo naukowe
Tytuł :
Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors.
Autorzy :
Yi F; Department of Biomedical and Pharmaceutical Sciences and Center for Structural and Functional Neuroscience, University of Montana, Missoula, MT, USA.; Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, MT, USA.
Bhattacharya S; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
Thompson CM; Department of Biomedical and Pharmaceutical Sciences and Center for Structural and Functional Neuroscience, University of Montana, Missoula, MT, USA.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
Hansen KB; Department of Biomedical and Pharmaceutical Sciences and Center for Structural and Functional Neuroscience, University of Montana, Missoula, MT, USA.; Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, MT, USA.
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Źródło :
The Journal of physiology [J Physiol] 2019 Nov; Vol. 597 (22), pp. 5495-5514. Date of Electronic Publication: 2019 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Nerve Tissue Proteins/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Glutamic Acid/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Interneurons/drug effects ; Interneurons/metabolism ; Mice ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/metabolism ; Piperidines/pharmacology ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy.
Autorzy :
XiangWei W; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Kannan V; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Xu Y; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kosobucki GJ; Department of Neurobiology, University of Pittsburgh School of Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh PA, USA.
Schulien AJ; Department of Neurobiology, University of Pittsburgh School of Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh PA, USA.
Kusumoto H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Moufawad El Achkar C; Division of Epilepsy, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Bhattacharya S; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Lesca G; Service de Genetique, Centre de Reference Anomalies du Developpement, Hospices Civils de Lyon, Bron, France; INSERM U1028, CNRS UMR5292, Paris, France.; Centre de Recherche en Neurosciences de Lyon, GENDEV Team, Universite Claude Bernard Lyon 1, Bron, France; Claude Bernard Lyon I University, Lyon, France.
Nguyen S; Department of Pediatric Neurology, University Hospital of Lille, and Lille Reference Centre for Rare Epileptic Disorders, Lille, France.
Helbig KL; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Cuisset JM; Department of Pediatric Neurology, University Hospital of Lille, and Lille Reference Centre for Rare Epileptic Disorders, Lille, France.
Fenger CD; Danish Epilepsy Centre Filadelfia, Dianalund, Denmark.
Marjanovic D; Danish Epilepsy Centre Filadelfia, Dianalund, Denmark.
Schuler E; Division of Child Neurology and Inherited Metabolic Diseases, Centre for Paediatrics and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Wu Y; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.
Bao X; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.
Zhang Y; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.
Dirkx N; Neurogenetics Group, University of Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Schoonjans AS; Department of Child Neurology, Antwerp University Hospital, Antwerp, Belgium.
Syrbe S; Division of Child Neurology and Inherited Metabolic Diseases, Centre for Paediatrics and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Myers SJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, USA.
Poduri A; Division of Epilepsy, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.
Aizenman E; Department of Neurobiology, University of Pittsburgh School of Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh PA, USA.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, USA.
Lemke JR; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, Germany.
Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, USA.
Jiang Y; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.
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Źródło :
Brain : a journal of neurology [Brain] 2019 Oct 01; Vol. 142 (10), pp. 3009-3027.
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epilepsy, Generalized/*genetics
Receptors, N-Methyl-D-Aspartate/*genetics
Adult ; Amino Acid Sequence/genetics ; Animals ; Child ; Child, Preschool ; Epilepsy, Generalized/physiopathology ; Female ; Gene Expression Regulation/genetics ; Glutamic Acid/metabolism ; HEK293 Cells ; Humans ; Male ; Neurons/metabolism ; Polymorphism, Single Nucleotide/genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synaptic Transmission/genetics
Czasopismo naukowe
Tytuł :
Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([ F]N2B-0518) for GluN2B Subunit in the Brain.
Autorzy :
Fu H; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Tang W; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.; Department of Neurology, Xiangya Hospital , Central South University , Changsha , Hunan 410008 , P. R. China.
Chen Z; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Belov VV; Department of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Zhang G; Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019 , United States.
Shao T; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Zhang X; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Yu Q; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Rong J; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Deng X; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Han W; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.; Department of Neurology , Children's Hospital of Chongqing Medical University , Chongqing , 400014 , P. R. China.
Myers SJ; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Giffenig P; Department of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Wang L; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.; Department of Nuclear Medicine and PET/CT-MRI Center, the First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging , Jinan University , Guangzhou 510630 , P. R. China.
Josephson L; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Shao Y; Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019 , United States.
Davenport AT; Department of Physiology and Pharmacology, Wake Forest School of Medicine , Winston Salem , North Carolina 27157 , United States.
Daunais JB; Department of Physiology and Pharmacology, Wake Forest School of Medicine , Winston Salem , North Carolina 27157 , United States.
Papisov M; Department of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Yuan H; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Li Z; State Key Laboratory of Molecular Vaccinology, Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine, School of Public Health , Xiamen University , Xiamen 361102 , P. R. China.
Traynelis SF; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Liang SH; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2019 May 15; Vol. 10 (5), pp. 2263-2275. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Triazoles*
Brain/*diagnostic imaging
Positron-Emission Tomography/*methods
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Autoradiography ; Brain/metabolism ; Fluorine Radioisotopes ; Radiopharmaceuticals ; Rats
Czasopismo naukowe
Tytuł :
Tonic Activation of GluN2C/GluN2D-Containing NMDA Receptors by Ambient Glutamate Facilitates Cortical Interneuron Maturation.
Autorzy :
Hanson E; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.; Neuroscience Program, Tufts Sackler School of Biomedical Sciences, Boston, Massachusetts 02111.
Armbruster M; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.
Lau LA; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.; Neuroscience Program, Tufts Sackler School of Biomedical Sciences, Boston, Massachusetts 02111.
Sommer ME; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.
Klaft ZJ; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.
Swanger SA; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322.
Moss SJ; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, and.
Noubary F; Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts 02115.
Chadchankar J; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, and.
Dulla CG; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2019 May 08; Vol. 39 (19), pp. 3611-3626. Date of Electronic Publication: 2019 Mar 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutamic Acid/*metabolism
Interneurons/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Sensorimotor Cortex/*metabolism
Animals ; Animals, Newborn ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/pharmacology ; Extracellular Fluid/drug effects ; Extracellular Fluid/metabolism ; Female ; Interneurons/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Organ Culture Techniques ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Sensorimotor Cortex/drug effects
Czasopismo naukowe
Tytuł :
Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue.
Autorzy :
Carruthers NI; Janssen Research & Development, LLC, La Jolla, California 92121, United States.
Lovenberg TW; Janssen Research & Development, LLC, La Jolla, California 92121, United States.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
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Źródło :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Mar 14; Vol. 10 (3), pp. 226. Date of Electronic Publication: 2019 Mar 14 (Print Publication: 2019).
Typ publikacji :
Editorial
Opinia redakcyjna
Tytuł :
Antidepressant-relevant concentrations of the ketamine metabolite (2 R ,6 R )-hydroxynorketamine do not block NMDA receptor function.
Autorzy :
Lumsden EW; Department of Epidemiology and Public Health, Division of Translational Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.
Troppoli TA; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
Myers SJ; Department of Pharmacology, Emory University, Atlanta, GA 30329.
Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
Aracava Y; Department of Epidemiology and Public Health, Division of Translational Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.
Kehr J; Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden.; Pronexus Analytical AB, SE-167 33 Bromma, Sweden.
Lovett J; Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224.
Kim S; Department of Pharmacology, Emory University, Atlanta, GA 30329.
Wang FH; Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden.; Pronexus Analytical AB, SE-167 33 Bromma, Sweden.
Schmidt S; Department of Physiology and Pharmacology, Karolinska Institute, SE-171 77 Stockholm, Sweden.; Pronexus Analytical AB, SE-167 33 Bromma, Sweden.
Jenne CE; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
Yuan P; Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
Morris PJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892.
Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892.
Zarate CA Jr; Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
Moaddel R; Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224.
Traynelis SF; Department of Pharmacology, Emory University, Atlanta, GA 30329.
Pereira EFR; Department of Epidemiology and Public Health, Division of Translational Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201.
Thompson SM; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
Albuquerque EX; Department of Epidemiology and Public Health, Division of Translational Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.
Gould TD; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201; .; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.; Veterans Affairs Maryland Health Care System, Baltimore, MD 21201.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Mar 12; Vol. 116 (11), pp. 5160-5169. Date of Electronic Publication: 2019 Feb 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antidepressive Agents/*pharmacology
Ketamine/*pharmacology
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Behavior, Animal/drug effects ; Excitatory Postsynaptic Potentials/drug effects ; Hippocampus/drug effects ; Hippocampus/metabolism ; Inhibitory Concentration 50 ; Ketamine/administration & dosage ; Ketamine/chemistry ; Male ; Mice ; N-Methylaspartate/metabolism ; Protein Subunits/metabolism ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Rats ; Xenopus laevis
Czasopismo naukowe
Tytuł :
AMPA-Type Glutamate Receptor Conductance Changes and Plasticity: Still a Lot of Noise.
Autorzy :
Benke T; Departments of Pediatrics, Pharmacology, Neurology and Otolaryngology, University of Colorado, School of Medicine, Anschutz Medical Campus, Aurora, CO, USA. .
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
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Źródło :
Neurochemical research [Neurochem Res] 2019 Mar; Vol. 44 (3), pp. 539-548. Date of Electronic Publication: 2018 Feb 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Excitatory Postsynaptic Potentials/*physiology
Hippocampus/*metabolism
Long-Term Potentiation/*physiology
Neuronal Plasticity/*physiology
Receptors, AMPA/*metabolism
Animals ; Excitatory Postsynaptic Potentials/drug effects ; Hippocampus/drug effects ; Humans ; Long-Term Potentiation/drug effects ; Neuronal Plasticity/drug effects ; Receptors, AMPA/drug effects ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.
Autorzy :
Regan MC; WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.
Zhu Z; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, Shaanxi, China.
Yuan H; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Myers SJ; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Menaldino DS; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Tahirovic YA; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Liotta DC; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Furukawa H; WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Jan 18; Vol. 10 (1), pp. 321. Date of Electronic Publication: 2019 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Propanolamines/*pharmacology
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Animals ; Binding Sites ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Mutagenesis, Site-Directed ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Oocytes ; Patch-Clamp Techniques ; Propanolamines/chemistry ; Rats ; Receptors, N-Methyl-D-Aspartate/chemistry ; Xenopus laevis
Czasopismo naukowe

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