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    Wyświetlanie 1-17 z 17
    Tytuł:
    Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.
    Autorzy:
    Camp CR; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
    Vlachos A; Section on Cellular and Synaptic Physiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
    Klöckner C; Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
    Krey I; Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
    Banke TG; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
    Shariatzadeh N; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
    Ruggiero SM; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; The Epilepsy NeuroGenetics Initiative, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
    Galer P; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, 19146, USA.
    Park KL; University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.
    Caccavano A; Section on Cellular and Synaptic Physiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
    Kimmel S; Section on Cellular and Synaptic Physiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
    Yuan X; Section on Cellular and Synaptic Physiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
    Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Center for Functional Evaluation of Rare Variants, Emory University School of Medicine, Atlanta, GA, 30322, USA.
    Helbig I; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; The Epilepsy NeuroGenetics Initiative, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, 19146, USA.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
    Benke TA; University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.
    Lemke JR; Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.; Center for Rare Diseases, University of Leipzig Medical Center, Leipzig, Germany.
    Pelkey KA; Section on Cellular and Synaptic Physiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
    McBain CJ; Section on Cellular and Synaptic Physiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
    Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA. .; Center for Functional Evaluation of Rare Variants, Emory University School of Medicine, Atlanta, GA, 30322, USA. .; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, 30322, USA. .
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    Źródło:
    Communications biology [Commun Biol] 2023 Sep 19; Vol. 6 (1), pp. 952. Date of Electronic Publication: 2023 Sep 19.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Calcium*
    Parvalbumins*/genetics
    Receptors, N-Methyl-D-Aspartate*/genetics
    Animals ; Mice ; Hippocampus ; Interneurons ; Seizures
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Recurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy.
    Autorzy:
    Xu Y; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
    Song R; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
    Chen W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
    Strong K; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
    Shrey D; Division of Neurology, Children's Hospital of Orange County, Orange, California, USA.; Department of Pediatrics, University of California Irvine, Irvine, California, USA.
    Gedela S; Division of Neurology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
    Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, Georgia, USA.
    Zhang G; Division of Neurology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
    Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, Georgia, USA.
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    Źródło:
    Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2021 Jul; Vol. 8 (7), pp. 1480-1494. Date of Electronic Publication: 2021 Jul 06.
    Typ publikacji:
    Case Reports; Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Genetic Variation/*genetics
    Mutation, Missense/*genetics
    Nerve Tissue Proteins/*genetics
    Receptors, N-Methyl-D-Aspartate/*genetics
    Seizures/*genetics
    Exome Sequencing/*methods
    Adolescent ; Amino Acid Sequence ; Animals ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Child, Preschool ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agents/pharmacology ; Female ; HEK293 Cells ; Humans ; Male ; Nerve Tissue Proteins/agonists ; Nerve Tissue Proteins/chemistry ; Pedigree ; Protein Structure, Secondary ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/chemistry ; Recurrence ; Seizures/drug therapy ; Seizures/physiopathology ; Xenopus laevis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Correction to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
    Autorzy:
    Park H; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.
    Han KS; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea.
    Seo J; Department of Physiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.
    Lee J; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.
    Dravid SM; Department of Pharmacology, Creighton University, Omaha, NE, USA.
    Woo J; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea.
    Chun H; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.
    Cho S; Department of Physiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea.
    Bae JY; Department of Oral Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
    An H; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea.
    Koh W; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea.
    Yoon BE; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea.; Department of Nanobiomedical Science, Dankook University, Cheonan, Korea.
    Berlinguer-Palmini R; School of Electrical and Electronic Engineering, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
    Mannaioni G; Department of Pharmacology, University of Florence, Florence, Italy.
    Traynelis SF; Department of Pharmacology, Emory University, Atlanta, GA, USA.
    Bae YC; Department of Oral Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
    Choi SY; Department of Physiology and Dental Research Institute, Seoul National University School of Dentistry, Seoul, Korea. .
    Lee CJ; Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Korea. .; Neuroscience Program, University of Science and Technology (UST), Daejeon, Korea. .; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea. .
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    Źródło:
    Molecular brain [Mol Brain] 2021 Jun 29; Vol. 14 (1), pp. 103. Date of Electronic Publication: 2021 Jun 29.
    Typ publikacji:
    Published Erratum
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.
    Autorzy:
    Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
    Dlugos D; Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
    Henshall D; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
    Mefford HC; Department of Pediatrics, University of Washington, Seattle, WA, USA.
    Rogawski MA; Departments of Neurology and Pharmacology, School of Medicine, University of California, Davis, Sacramento, CA, USA.
    Staley KJ; Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
    Dacks PA; American Epilepsy Society, Chicago, IL, USA.
    Whittemore V; Division of Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MA, USA.
    Poduri A; Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
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    Corporate Authors:
    National Institutes of Neurological Disorders and Stroke (NINDS)/American Epilepsy Society (AES) Epilepsy Research Benchmark Stewards
    Źródło:
    Epilepsy currents [Epilepsy Curr] 2020 Jan-Feb; Vol. 20 (1_suppl), pp. 23S-30S. Date of Electronic Publication: 2020 Jan 22.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors.
    Autorzy:
    Bhattacharya S; Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA.
    Traynelis SF; Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA.
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    Źródło:
    Journal of experimental neuroscience [J Exp Neurosci] 2018 Nov 19; Vol. 12, pp. 1179069518810423. Date of Electronic Publication: 2018 Nov 19 (Print Publication: 2018).
    Typ publikacji:
    Journal Article; Comment
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.
    Autorzy:
    Gao K; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.
    Tankovic A; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.
    Zhang Y; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.
    Kusumoto H; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.
    Zhang J; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.
    Chen W; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
    XiangWei W; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.
    Shaulsky GH; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.
    Hu C; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.
    Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.; Center for Functional Evaluation of Rare Variant (CFERV), Emory University School of Medicine, Atlanta, GA, United States of America.
    Yuan H; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States of America.; Center for Functional Evaluation of Rare Variant (CFERV), Emory University School of Medicine, Atlanta, GA, United States of America.
    Jiang Y; Department of Pediatrics and Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China.; Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China.
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    Źródło:
    PloS one [PLoS One] 2017 Feb 09; Vol. 12 (2), pp. e0170818. Date of Electronic Publication: 2017 Feb 09 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Electroencephalography*
    Epilepsies, Partial*/genetics
    Epilepsies, Partial*/metabolism
    Epilepsies, Partial*/physiopathology
    Landau-Kleffner Syndrome*/genetics
    Landau-Kleffner Syndrome*/metabolism
    Landau-Kleffner Syndrome*/physiopathology
    Mutation, Missense*
    Receptors, N-Methyl-D-Aspartate*/genetics
    Receptors, N-Methyl-D-Aspartate*/metabolism
    Membrane Potentials/*genetics
    Amino Acid Substitution ; Female ; HEK293 Cells ; High-Throughput Nucleotide Sequencing ; Humans ; Male
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.
    Autorzy:
    Ogden KK; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Chen W; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
    Swanger SA; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    McDaniel MJ; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Fan LZ; Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, United States of America.
    Hu C; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Tankovic A; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Kusumoto H; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Kosobucki GJ; Department of Neurobiology, University of Pittsburgh School of Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, United States of America.
    Schulien AJ; Department of Neurobiology, University of Pittsburgh School of Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, United States of America.
    Su Z; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Pecha J; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Bhattacharya S; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
    Petrovski S; Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
    Cohen AE; Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, United States of America.
    Aizenman E; Department of Neurobiology, University of Pittsburgh School of Medicine and Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, United States of America.
    Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, United States of America.
    Yuan H; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America.; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia, United States of America.
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    Źródło:
    PLoS genetics [PLoS Genet] 2017 Jan 17; Vol. 13 (1), pp. e1006536. Date of Electronic Publication: 2017 Jan 17 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Ion Channel Gating*
    Mutation, Missense*
    Nerve Tissue Proteins/*metabolism
    Nervous System Diseases/*genetics
    Receptors, N-Methyl-D-Aspartate/*metabolism
    Animals ; Cells, Cultured ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamic Acid/metabolism ; HEK293 Cells ; Humans ; Memantine/pharmacology ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Neurons/metabolism ; Neurons/physiology ; Protein Domains ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/chemistry ; Receptors, N-Methyl-D-Aspartate/genetics ; Xenopus
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
    Autorzy:
    Park H
    Han KS
    Seo J
    Lee J
    Dravid SM
    Woo J
    Chun H
    Cho S
    Bae JY
    An H
    Koh W
    Yoon BE
    Berlinguer-Palmini R
    Mannaioni G
    Traynelis SF
    Bae YC
    Choi SY
    Lee CJ
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    Źródło:
    Molecular brain [Mol Brain] 2015 Feb 03; Vol. 8, pp. 7. Date of Electronic Publication: 2015 Feb 03.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Neuronal Plasticity*
    Astrocytes/*metabolism
    Eye Proteins/*metabolism
    Glutamic Acid/*metabolism
    Hippocampus/*metabolism
    Ion Channels/*metabolism
    Receptors, N-Methyl-D-Aspartate/*metabolism
    Animals ; Bestrophins ; CA1 Region, Hippocampal/metabolism ; CA1 Region, Hippocampal/ultrastructure ; Hippocampus/ultrastructure ; Humans ; Long-Term Potentiation ; Mice ; Models, Biological ; Receptor, PAR-1/metabolism ; Synapses/metabolism ; Synaptic Transmission
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Randomized, Placebo-Controlled, Double-Blind Pilot Study of D-Cycloserine in Chronic Stroke.
    Autorzy:
    Butler AJ; Department of Physical Therapy, School of Nursing and Health Professions, Georgia State University, Atlanta, GA 30303, USA ; Atlanta Veterans Affairs Medical Center, Rehabilitation Research and Development Center of Excellence for Visual and Neurocognitive Rehabilitation, Decatur, GA 30033, USA.
    Kallos J; Department of Physical Therapy, School of Nursing and Health Professions, Georgia State University, Atlanta, GA 30303, USA.
    Housley SN; Department of Physical Therapy, School of Nursing and Health Professions, Georgia State University, Atlanta, GA 30303, USA.
    LaPlaca MC; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
    Traynelis SF; Department of Pharmacology, Emory University, Atlanta, GA 30332, USA.
    Wolf SL; Atlanta Veterans Affairs Medical Center, Rehabilitation Research and Development Center of Excellence for Visual and Neurocognitive Rehabilitation, Decatur, GA 30033, USA ; Division of Physical Therapy, Department of Rehabilitation Medicine, Emory University School of Medicine, USA.
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    Źródło:
    Rehabilitation research and practice [Rehabil Res Pract] 2015; Vol. 2015, pp. 534239. Date of Electronic Publication: 2015 Oct 26.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis.
    Autorzy:
    Oh SJ; Korea Institute of Science and Technology, Seoul, South Korea.
    Han KS
    Park H
    Woo DH
    Kim HY
    Traynelis SF
    Lee CJ
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    Źródło:
    Molecular brain [Mol Brain] 2012 Oct 12; Vol. 5, pp. 38. Date of Electronic Publication: 2012 Oct 12.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Exocytosis*/drug effects
    Astrocytes/*metabolism
    Cytoplasmic Vesicles/*metabolism
    Eye Proteins/*metabolism
    Glutamic Acid/*metabolism
    Ion Channels/*metabolism
    Receptor, PAR-1/*metabolism
    Animals ; Anions ; Astrocytes/drug effects ; Bestrophins ; Calcium Channel Blockers/pharmacology ; Calcium Channels/metabolism ; Cells, Cultured ; Chromatography, High Pressure Liquid ; Cytoplasmic Vesicles/drug effects ; Fluorescence Resonance Energy Transfer ; Mice ; Oligopeptides/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    NMDA receptor permeation: a light in the tunnel.
    Autorzy:
    Wyllie DJ; Centre for Integrative Physiology at the University of Edinburgh, Edinburgh, UK. />Traynelis SF
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    Źródło:
    Nature neuroscience [Nat Neurosci] 2012 Feb 24; Vol. 15 (3), pp. 343-4. Date of Electronic Publication: 2012 Feb 24.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
    MeSH Terms:
    Ion Channel Gating/*physiology
    Receptors, N-Methyl-D-Aspartate/*metabolism
    Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus.
    Autorzy:
    Han KS; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA.
    Mannaioni G
    Hamill CE
    Lee J
    Junge CE
    Lee CJ
    Traynelis SF
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    Źródło:
    Molecular brain [Mol Brain] 2011 Aug 10; Vol. 4, pp. 32. Date of Electronic Publication: 2011 Aug 10.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Action Potentials/*physiology
    Dentate Gyrus/*cytology
    Hippocampus/*cytology
    Neurons/*physiology
    Receptor, PAR-1/*metabolism
    Animals ; Calcium/metabolism ; Cells, Cultured ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/cytology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Receptor, PAR-1/genetics ; Synaptic Transmission/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating.
    Autorzy:
    Kristensen AS; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA.
    Jenkins MA
    Banke TG
    Schousboe A
    Makino Y
    Johnson RC
    Huganir R
    Traynelis SF
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    Źródło:
    Nature neuroscience [Nat Neurosci] 2011 Jun; Vol. 14 (6), pp. 727-35. Date of Electronic Publication: 2011 Apr 24.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
    Hippocampus/*cytology
    Membrane Proteins/*metabolism
    Neurons/*metabolism
    Receptors, AMPA/*genetics
    Receptors, AMPA/*metabolism
    Animals ; Gene Expression Regulation/genetics ; Gene Knock-In Techniques ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; Serine/metabolism ; Signal Transduction/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Adenosine A(2A) receptor mediates microglial process retraction.
    Autorzy:
    Orr AG; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA. />Orr AL
    Li XJ
    Gross RE
    Traynelis SF
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    Źródło:
    Nature neuroscience [Nat Neurosci] 2009 Jul; Vol. 12 (7), pp. 872-8. Date of Electronic Publication: 2009 Jun 14.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Microglia/*physiology
    Receptors, Adenosine A2/*metabolism
    Receptors, Purinergic P2/*metabolism
    Adenosine/analogs & derivatives ; Adenosine/metabolism ; Adenosine/pharmacology ; Adenosine A2 Receptor Agonists ; Adenosine Triphosphate/metabolism ; Animals ; Astrocytes/physiology ; Cells, Cultured ; Chemotaxis/physiology ; Coculture Techniques ; Humans ; Lipopolysaccharides/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia/cytology ; Neurotransmitter Agents/pharmacology ; Phenethylamines/pharmacology ; RNA, Messenger/metabolism ; Receptors, Purinergic P2Y12 ; Signal Transduction/physiology ; Video Recording
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Structural basis for partial agonist action at ionotropic glutamate receptors.
    Autorzy:
    Jin R; Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168 Street, New York, New York 10032, USA.
    Banke TG
    Mayer ML
    Traynelis SF
    Gouaux E
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    Źródło:
    Nature neuroscience [Nat Neurosci] 2003 Aug; Vol. 6 (8), pp. 803-10.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Alanine/*analogs & derivatives
    Receptors, AMPA/*agonists
    Receptors, AMPA/*drug effects
    Alanine/chemistry ; Alanine/pharmacology ; Animals ; Cell Line ; Crystallography, X-Ray ; Electric Conductivity ; Electrophysiology ; Humans ; Ion Channels/physiology ; Ligands ; Models, Biological ; Molecular Conformation ; Oocytes ; Pyrimidinones ; Receptors, AMPA/chemistry ; Receptors, AMPA/metabolism ; Uracil ; Xenopus laevis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Activation of NR1/NR2B NMDA receptors.
    Autorzy:
    Banke TG; Emory University School of Medicine, Department of Pharmacology, 1510 Clifton Road, Atlanta, Georgia 30322, USA. />Traynelis SF
    Pokaż więcej
    Źródło:
    Nature neuroscience [Nat Neurosci] 2003 Feb; Vol. 6 (2), pp. 144-52.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Central Nervous System/*physiology
    Receptors, N-Methyl-D-Aspartate/*physiology
    Synapses/*physiology
    Synaptic Transmission/*physiology
    Cells, Cultured ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists/pharmacology ; Glutamic Acid/metabolism ; Glutamic Acid/pharmacology ; Glycine/metabolism ; Glycine/pharmacology ; Humans ; Ligands ; Membrane Potentials/drug effects ; Membrane Potentials/physiology ; Models, Neurological ; Molecular Sequence Data ; Molecular Structure ; Reaction Time/drug effects ; Reaction Time/physiology ; Receptors, N-Methyl-D-Aspartate/drug effects ; Synapses/drug effects ; Synaptic Transmission/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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