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Wyszukujesz frazę ""Traynelis Stephen F."" wg kryterium: Autor


Tytuł :
The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.
Autorzy :
Strong, Katie L.
Epplin, Matthew P.
Bacsa, John
Butch, Christopher J.
Burger, Pieter B.
Menaldino, David S.
Traynelis, Stephen F.
Liotta, Dennis C.
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Źródło :
Journal of Medicinal Chemistry. Jul2017, Vol. 60 Issue 13, p5556-5585. 30p.
Czasopismo naukowe
Tytuł :
Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain.
Autorzy :
Tamborini, Lucia
Ying Chen
Foss, Catherine A.
Pinto, Andrea
Horti, Andrew G.
Traynelis, Stephen F.
De Micheli, Carlo
Mease, Ronnie C.
Hansen, Kasper B.
Conti, Paola
Pomper, Martin G.
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Źródło :
Journal of Medicinal Chemistry. Dec2016, Vol. 59 Issue 24, p11110-11119. 10p.
Czasopismo naukowe
Tytuł :
Quinazolin-4-one Derivatives: A Novel Class of Noncompetitive NR2C/D Subunit-Selective N-Methyl-d-aspartate Receptor Antagonists.
Autorzy :
Mosley, Cara A. (AUTHOR)
Acker, Timothy M. (AUTHOR)
Hansen, Kasper B. (AUTHOR)
Mullasseril, Praseeda (AUTHOR)
Andersen, Karen T. (AUTHOR)
Le, Phuong (AUTHOR)
Vellano, Kimberly M. (AUTHOR)
Bräuner-Osborne, Hans (AUTHOR)
Liotta, Dennis C. (AUTHOR)
Traynelis, Stephen F. (AUTHOR)
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Źródło :
Journal of Medicinal Chemistry. 8/12/2010, Vol. 53 Issue 15, p5476-5490. 15p.
Czasopismo naukowe
Tytuł :
Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N -Methyl-d-aspartate Receptors.
Autorzy :
Strong KL; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Epplin MP; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Ogden KK; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Burger PB; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Kaiser TM; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Wilding TJ; Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63110, United States.
Kusumoto H; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Camp CR; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Shaulsky G; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Bhattacharya S; Department of Drug Discovery and Development, Auburn University, Auburn, Alabama 36849, United States.
Perszyk RE; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Menaldino DS; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
McDaniel MJ; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Zhang J; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Le P; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Banke TG; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Hansen KB; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.; Center for Biomolecular Structure and Dynamics, Center for Structural and Functional Neuroscience, Division for Biological Sciences, University of Montana, 32 Campus Drive, Missoula, Montana 59812, United States.
Huettner JE; Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63110, United States.
Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Traynelis SF; Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jan 06; Vol. 12 (1), pp. 79-98. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Discovery of Dihydropyrrolo[1,2- a ]pyrazin-3(4 H )-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N -Methyl-d-Aspartate (NMDA) Receptor.
Autorzy :
Epplin MP; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Mohan A; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Harris LD; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Zhu Z; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Strong KL; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Bacsa J; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Le P; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Menaldino DS; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7569-7600. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Pyrazines/*pharmacology
Pyrroles/*pharmacology
Receptors, N-Methyl-D-Aspartate/*agonists
Allosteric Regulation ; Animals ; Drug Design ; Isoquinolines/chemical synthesis ; Isoquinolines/pharmacology ; Male ; Mice, Inbred C57BL ; Molecular Structure ; Pyrazines/chemical synthesis ; Pyrazines/pharmacokinetics ; Pyrroles/chemical synthesis ; Pyrroles/pharmacokinetics ; Structure-Activity Relationship ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([ F]N2B-0518) for GluN2B Subunit in the Brain.
Autorzy :
Fu H; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Tang W; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.; Department of Neurology, Xiangya Hospital , Central South University , Changsha , Hunan 410008 , P. R. China.
Chen Z; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Belov VV; Department of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Zhang G; Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019 , United States.
Shao T; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Zhang X; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Yu Q; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Rong J; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Deng X; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Han W; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.; Department of Neurology , Children's Hospital of Chongqing Medical University , Chongqing , 400014 , P. R. China.
Myers SJ; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Giffenig P; Department of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Wang L; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.; Department of Nuclear Medicine and PET/CT-MRI Center, the First Affiliated Hospital of Jinan University & Institute of Molecular and Functional Imaging , Jinan University , Guangzhou 510630 , P. R. China.
Josephson L; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Shao Y; Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019 , United States.
Davenport AT; Department of Physiology and Pharmacology, Wake Forest School of Medicine , Winston Salem , North Carolina 27157 , United States.
Daunais JB; Department of Physiology and Pharmacology, Wake Forest School of Medicine , Winston Salem , North Carolina 27157 , United States.
Papisov M; Department of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Yuan H; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Li Z; State Key Laboratory of Molecular Vaccinology, Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine, School of Public Health , Xiamen University , Xiamen 361102 , P. R. China.
Traynelis SF; Department of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Liang SH; Department of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2019 May 15; Vol. 10 (5), pp. 2263-2275. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Triazoles*
Brain/*diagnostic imaging
Positron-Emission Tomography/*methods
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Autoradiography ; Brain/metabolism ; Fluorine Radioisotopes ; Radiopharmaceuticals ; Rats
Czasopismo naukowe
Tytuł :
Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue.
Autorzy :
Carruthers NI; Janssen Research & Development, LLC, La Jolla, California 92121, United States.
Lovenberg TW; Janssen Research & Development, LLC, La Jolla, California 92121, United States.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
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Źródło :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Mar 14; Vol. 10 (3), pp. 226. Date of Electronic Publication: 2019 Mar 14 (Print Publication: 2019).
Typ publikacji :
Editorial
Opinia redakcyjna
Tytuł :
Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor.
Autorzy :
Summer SL; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Kell SA; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Zhu Z; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Moore R; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Liotta DC; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Myers SJ; NeurOp Inc., 58 Edgewood Avenue, Atlanta, Georgia 30303, United States.; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Koszalka GW; NeurOp Inc., 58 Edgewood Avenue, Atlanta, Georgia 30303, United States.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Menaldino DS; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
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Źródło :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Jan 04; Vol. 10 (3), pp. 248-254. Date of Electronic Publication: 2019 Jan 04 (Print Publication: 2019).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue.
Autorzy :
Carruthers NI; Janssen Research & Development, LLC, La Jolla, California 92121, United States.
Lovenberg TW; Janssen Research & Development, LLC, La Jolla, California 92121, United States.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
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Źródło :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 May 10; Vol. 9 (5), pp. 398-399. Date of Electronic Publication: 2018 May 10 (Print Publication: 2018).
Typ publikacji :
Editorial
Opinia redakcyjna
Tytuł :
A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.
Autorzy :
Swanger SA; Department of Pharmacology, Emory University School of Medicine , Atlanta, Georgia 30322, United States.
Vance KM; Department of Pharmacology, Emory University School of Medicine , Atlanta, Georgia 30322, United States.
Acker TM; Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.
Zimmerman SS; Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.
DiRaddo JO; Department of Pharmacology, Emory University School of Medicine , Atlanta, Georgia 30322, United States.; Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.
Myers SJ; Department of Pharmacology, Emory University School of Medicine , Atlanta, Georgia 30322, United States.
Bundgaard C; Discovery DMPK, H. Lundbeck A/S , Ottiliavej 9, DK-2500 Valby, Denmark.
Mosley CA; Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.
Summer SL; Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.
Menaldino DS; Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.
Jensen HS; Molecular Screening, H. Lundbeck A/S , Ottiliavej 9, DK-2500 Valby, Denmark.
Liotta DC; Department of Chemistry, Emory University , Atlanta, Georgia 30322, United States.
Traynelis SF; Department of Pharmacology, Emory University School of Medicine , Atlanta, Georgia 30322, United States.
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Źródło :
ACS chemical neuroscience [ACS Chem Neurosci] 2018 Feb 21; Vol. 9 (2), pp. 306-319. Date of Electronic Publication: 2017 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzamides/*pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Hippocampus/*drug effects
Interneurons/*drug effects
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Allosteric Regulation ; Animals ; Benzamides/chemistry ; Excitatory Amino Acid Antagonists/chemistry ; Female ; HEK293 Cells ; Hippocampus/metabolism ; Humans ; Interneurons/metabolism ; Male ; Mice, Inbred C57BL ; Mutagenesis, Site-Directed ; Oocytes ; Protein Structure, Secondary ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Structure-Activity Relationship ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Tissue Culture Techniques ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors.
Autorzy :
Santangelo Freel RM
Ogden KK
Strong KL
Khatri A
Chepiga KM
Jensen HS
Traynelis SF
Liotta DC
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2014 Jun 12; Vol. 57 (11), pp. 4975. Date of Electronic Publication: 2014 May 30.
Typ publikacji :
Published Erratum
Tytuł :
Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.
Autorzy :
Zimmerman SS; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Khatri A
Garnier-Amblard EC
Mullasseril P
Kurtkaya NL
Gyoneva S
Hansen KB
Traynelis SF
Liotta DC
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2014 Mar 27; Vol. 57 (6), pp. 2334-56. Date of Electronic Publication: 2014 Feb 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Excitatory Amino Acid Agonists/*chemical synthesis
Excitatory Amino Acid Agonists/*pharmacology
Receptors, N-Methyl-D-Aspartate/*agonists
Animals ; Chromatography, High Pressure Liquid ; Computational Biology ; Drug Design ; High-Throughput Screening Assays ; Humans ; Indicators and Reagents ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Conformation ; Oocytes/drug effects ; Patch-Clamp Techniques ; Pyrrolidinones/chemical synthesis ; Pyrrolidinones/pharmacology ; Pyruvates/chemical synthesis ; Pyruvates/pharmacology ; Stereoisomerism ; Structure-Activity Relationship ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.
Autorzy :
Acker TM; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States. />Khatri A
Vance KM
Slabber C
Bacsa J
Snyder JP
Traynelis SF
Liotta DC
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2013 Aug 22; Vol. 56 (16), pp. 6434-56. Date of Electronic Publication: 2013 Aug 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Excitatory Amino Acid Antagonists/*pharmacology
Pyrazoles/*chemistry
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Blood-Brain Barrier ; Humans ; Microsomes, Liver/metabolism ; Models, Molecular ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.
Autorzy :
Santangelo Freel RM; Department of Chemistry, Emory University , 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Ogden KK
Strong KL
Khatri A
Chepiga KM
Jensen HS
Traynelis SF
Liotta DC
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2013 Jul 11; Vol. 56 (13), pp. 5351-81. Date of Electronic Publication: 2013 Jun 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Excitatory Amino Acid Agonists/*pharmacology
Receptors, N-Methyl-D-Aspartate/*agonists
Tetrahydroisoquinolines/*pharmacology
Animals ; Cell Line ; Excitatory Amino Acid Agonists/chemical synthesis ; Female ; Glutamic Acid/pharmacology ; Glycine/pharmacology ; Membrane Potentials/drug effects ; Models, Chemical ; Molecular Structure ; Oocytes/drug effects ; Oocytes/metabolism ; Oocytes/physiology ; Protein Subunits/agonists ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Rats ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Structure-Activity Relationship ; Tetrahydroisoquinolines/chemical synthesis ; Tetrahydroisoquinolines/chemistry ; Xenopus laevis
Czasopismo naukowe

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