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Wyszukujesz frazę ""Triazoles"" wg kryterium: Temat


Starter badań:

Tytuł :
Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease.
Autorzy :
Wang M; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China.
Fang L; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China.
Liu T; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China.
Chen X; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China.
Zheng Y; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China.
Zhang Y; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China.
Chen S; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China.
Li Z; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, 230032, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jun 01; Vol. 342, pp. 109489. Date of Electronic Publication: 2021 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Anti-Inflammatory Agents/*therapeutic use
Cholinesterase Inhibitors/*therapeutic use
Hesperidin/*therapeutic use
Neuroprotective Agents/*therapeutic use
Triazoles/*therapeutic use
Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/metabolism ; Butyrylcholinesterase/metabolism ; Cell Line, Tumor ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/metabolism ; Drug Discovery ; Hesperidin/chemical synthesis ; Hesperidin/metabolism ; Ligands ; Male ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/metabolism ; Nitric Oxide/antagonists & inhibitors ; Protein Binding ; Rats ; Transcription Factor RelA/metabolism ; Triazoles/chemical synthesis ; Triazoles/metabolism
Czasopismo naukowe
Tytuł :
Tricyclic Triazoles as σ 1 Receptor Antagonists for Treating Pain.
Autorzy :
Díaz JL; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Cuevas F; The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
Oliva AI; The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
Font D; The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
Sarmentero MÁ; The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
Álvarez-Bercedo P; The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
López-Valbuena JM; The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.
Pericàs MA; The Barcelona Institute of Science and Technology, Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007 Tarragona, Spain.; Departament de Química Inorgànica i Orgànica, Universitat de Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain.
Enrech R; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Montero A; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Yeste S; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Vidal-Torres A; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Álvarez I; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Pérez P; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Cendán CM; Department of Pharmacology, Faculty of Medicine, University of Granada, 18016 Granada, Spain.; Biosanitary Research Institute ibs.GRANADA, 18012 Granada, Spain.
Cobos EJ; Department of Pharmacology, Faculty of Medicine, University of Granada, 18016 Granada, Spain.; Biosanitary Research Institute ibs.GRANADA, 18012 Granada, Spain.
Vela JM; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
Almansa C; Drug Discovery and Preclinical Development, ESTEVE Pharmaceuticals S.A., Carrer Baldiri Reixac, 4-8. Parc Científic de Barcelona, 08028 Barcelona, Spain.; WELAB, Parc Científic Barcelona, C/Baldiri Reixac 4-8, 08028 Barcelona, Spain.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5157-5170. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Analgesics/*chemistry
Receptors, sigma/*antagonists & inhibitors
Triazoles/*chemistry
Analgesics/metabolism ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Cell Membrane Permeability/drug effects ; Disease Models, Animal ; Female ; Half-Life ; Humans ; Ligands ; Male ; Mice ; Microsomes, Liver/metabolism ; Pain/drug therapy ; Rats ; Rats, Wistar ; Receptors, sigma/metabolism ; Structure-Activity Relationship ; Triazoles/metabolism ; Triazoles/pharmacology ; Triazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems.
Autorzy :
Grieco I; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Bissaro M; Molecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, via Marzolo 5, 35131, Padova, Italy.
Tiz DB; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Perez DI; Centro de Investigaciones Biologicas, CSIC, Ramiro de Maetzu 9, 28040, Madrid, Spain.
Perez C; Instituto de Quimica Medica, CSIC, Juan de la Cierva 3, 28006, Madrid, Spain.
Martinez A; Centro de Investigaciones Biologicas, CSIC, Ramiro de Maetzu 9, 28040, Madrid, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, 28031, Madrid, Spain.
Redenti S; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Mariotto E; Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Università di Padova, 35131, Padova, Italy.
Bortolozzi R; Istituto di Ricerca Pediatrica (IRP), Corso Stati Uniti 4, 35128, Padova, Italy.
Viola G; Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Università di Padova, 35131, Padova, Italy; Istituto di Ricerca Pediatrica (IRP), Corso Stati Uniti 4, 35128, Padova, Italy.
Cozza G; Dipartimento di Medicina Molecolare, Università degli Studi di Padova, Via U. Bassi 58/B, 35131, Padova, Italy.
Spalluto G; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Moro S; Molecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, via Marzolo 5, 35131, Padova, Italy.
Federico S; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113331. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Casein Kinase Idelta/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemistry
Triazoles/*chemistry
Binding Sites ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Casein Kinase Idelta/metabolism ; Cell Line ; Cell Survival/drug effects ; Drug Design ; Humans ; Kinetics ; Molecular Docking Simulation ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/chemistry ; Static Electricity ; Structure-Activity Relationship ; Thermodynamics ; Triazines/chemistry ; Triazoles/metabolism ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Popping candy-assisted dispersive liquid-liquid microextraction for enantioselective determination of prothioconazole and its chiral metabolite in water, beer, Baijiu, and vinegar samples by HPLC.
Autorzy :
Jing X; College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China; Graduate Education Innovation Center on Baijiu Bioengineering in Shanxi Province, Taigu, Shanxi 030801, PR China.
Huang X; College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China; Graduate Education Innovation Center on Baijiu Bioengineering in Shanxi Province, Taigu, Shanxi 030801, PR China.
Wang H; College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China.
Xue H; College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China; Graduate Education Innovation Center on Baijiu Bioengineering in Shanxi Province, Taigu, Shanxi 030801, PR China.
Wu B; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
Wang X; College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China.
Jia L; College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi 030801, PR China; Graduate Education Innovation Center on Baijiu Bioengineering in Shanxi Province, Taigu, Shanxi 030801, PR China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jun 30; Vol. 348, pp. 129147. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid*
Acetic Acid/*chemistry
Beer/*analysis
Liquid Phase Microextraction/*methods
Triazoles/*analysis
Water/*chemistry
Hydrogen-Ion Concentration ; Limit of Detection ; Principal Component Analysis ; Sodium Chloride/chemistry ; Stereoisomerism ; Temperature ; Triazoles/isolation & purification
Czasopismo naukowe
Tytuł :
Simultaneous enantiomeric determination of multiple triazole fungicides in fruits and vegetables by chiral liquid chromatography/tandem mass spectrometry on a bridged bis(β-cyclodextrin)-bonded chiral stationary phase.
Autorzy :
Shuang Y; College of Chemistry, Nanchang University, Nanchang 330031, China.
Zhang T; College of Chemistry, Nanchang University, Nanchang 330031, China.
Zhong H; College of Chemistry, Nanchang University, Nanchang 330031, China.
Li L; College of Chemistry, Nanchang University, Nanchang 330031, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 30; Vol. 345, pp. 128842. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Liquid/*methods
Food Analysis/*methods
Fruit/*chemistry
Tandem Mass Spectrometry/*methods
Triazoles/*analysis
Vegetables/*chemistry
beta-Cyclodextrins/*chemistry
Fungicides, Industrial/analysis ; Pesticide Residues/analysis ; Pesticide Residues/chemistry ; Stereoisomerism ; Time Factors ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Tebuconazole induced cytotoxic and genotoxic effects in HCT116 cells through ROS generation.
Autorzy :
Othmène YB; University of Monastir, Faculty of Dental Medicine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, Avicenne Street, 5000 Monastir, Tunisia; Higher Institute of Biotechnology, University of Monastir, Taher Haddad Street, 5000, Monastie, Tunisia.
Salem IB; University of Monastir, Faculty of Dental Medicine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, Avicenne Street, 5000 Monastir, Tunisia; Higher Institute of Biotechnology, University of Monastir, Taher Haddad Street, 5000, Monastie, Tunisia; University of Sousse, Faculty of Medicine of Sousse, 4000, Tunisia.
Hamdi H; University of Monastir, Faculty of Dental Medicine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, Avicenne Street, 5000 Monastir, Tunisia; Higher Institute of Biotechnology, University of Monastir, Taher Haddad Street, 5000, Monastie, Tunisia.
Annabi E; University of Monastir, Faculty of Dental Medicine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, Avicenne Street, 5000 Monastir, Tunisia; Higher Institute of Biotechnology, University of Monastir, Taher Haddad Street, 5000, Monastie, Tunisia.
Abid-Essefi S; University of Monastir, Faculty of Dental Medicine, Laboratory for Research on Biologically Compatible Compounds, LR01SE17, Avicenne Street, 5000 Monastir, Tunisia; Higher Institute of Biotechnology, University of Monastir, Taher Haddad Street, 5000, Monastie, Tunisia. Electronic address: .
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Źródło :
Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2021 May; Vol. 174, pp. 104797. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Triazoles*/toxicity
Animals ; Apoptosis ; HCT116 Cells ; Humans ; Oxidative Stress ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Different chemometric assisted approaches for spectrophotometric quantitative analysis of lesinurad and allopurinol.
Autorzy :
Abdelazim AH; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Shahin M; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Damanhour University, Beheira, Egypt. Electronic address: .
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Apr 15; Vol. 251, pp. 119421. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Allopurinol*
Triazoles*
Least-Squares Analysis ; Spectrophotometry ; Thioglycolates
Czasopismo naukowe
Tytuł :
Network meta-analysis of triazole, polyene, and echinocandin antifungal agents in invasive fungal infection prophylaxis in patients with hematological malignancies.
Autorzy :
Zeng H; Department of Hematology, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Wu Z; Emergency Department, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Yu B; Department of Hematology, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Wang B; Department of Hematology, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Wu C; Department of Hematology, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Wu J; Department of Hematology, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Lai J; Department of Hematology, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Gao X; Department of Hematology, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China.
Chen J; Department of Urology Surgery, the First Affiliated Hospital of Jinan University, No.613 West Huangpu street, Guangzhou, 510630, P. R. China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 14; Vol. 21 (1), pp. 404. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Antifungal Agents/*therapeutic use
Echinocandins/*therapeutic use
Hematologic Neoplasms/*complications
Invasive Fungal Infections/*etiology
Invasive Fungal Infections/*prevention & control
Polyenes/*therapeutic use
Triazoles/*therapeutic use
Echinocandins/administration & dosage ; Humans ; Network Meta-Analysis ; Polyenes/administration & dosage ; Pre-Exposure Prophylaxis ; Publication Bias ; Treatment Outcome ; Triazoles/administration & dosage
Czasopismo naukowe
Tytuł :
A rapid method for the simultaneous stereoselective determination of the triazole fungicides in tobacco by supercritical fluid chromatography-tandem mass spectrometry combined with pass-through cleanup.
Autorzy :
Yang F; China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
Zhang X; China tobacco Guizhou Industrial Co. Ltd, Guiyang 550009, China.
Shao J; Sichuan Tobacco Quality Supervision and Testing Station, Chengdu 610041, China.
Xiong W; Sichuan Tobacco Quality Supervision and Testing Station, Chengdu 610041, China.
Ji Y; China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
Liu S; China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
Tang G; China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
Deng H; China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
Wang Y; China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Apr 12; Vol. 1642, pp. 462040. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Supercritical Fluid/*methods
Fungicides, Industrial/*analysis
Tandem Mass Spectrometry/*methods
Tobacco/*chemistry
Triazoles/*analysis
Calibration ; Fungicides, Industrial/chemistry ; Limit of Detection ; Nitriles/analysis ; Nitriles/chemistry ; Reproducibility of Results ; Solid Phase Extraction ; Solvents ; Stereoisomerism ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Single dose pharmacokinetics of topical iodiconazole creams in healthy Chinese volunteers.
Autorzy :
Wu L; Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Zhou K; Department of dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Zong W; Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Chen Y; Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.
Sheng C; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Apr; Vol. 51 (4), pp. 427-433. Date of Electronic Publication: 2021 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Triazoles*
Area Under Curve ; Benzylamines ; China ; Cross-Over Studies ; Healthy Volunteers ; Humans ; Therapeutic Equivalency
Czasopismo naukowe
Tytuł :
Discovery of a novel family of FKBP12 "reshapers" and their use as calcium modulators in skeletal muscle under nitro-oxidative stress.
Autorzy :
Aizpurua JM; Joxe Mari Korta R&D Center, Departamento de Química Orgánica-I, Universidad Del País Vasco UPV/EHU, Avda. Tolosa-72, 20018, San Sebastián, Spain. Electronic address: .
Miranda JI; Joxe Mari Korta R&D Center, Departamento de Química Orgánica-I, Universidad Del País Vasco UPV/EHU, Avda. Tolosa-72, 20018, San Sebastián, Spain.
Irastorza A; Joxe Mari Korta R&D Center, Departamento de Química Orgánica-I, Universidad Del País Vasco UPV/EHU, Avda. Tolosa-72, 20018, San Sebastián, Spain.
Torres E; Joxe Mari Korta R&D Center, Departamento de Química Orgánica-I, Universidad Del País Vasco UPV/EHU, Avda. Tolosa-72, 20018, San Sebastián, Spain.
Eceiza M; Joxe Mari Korta R&D Center, Departamento de Química Orgánica-I, Universidad Del País Vasco UPV/EHU, Avda. Tolosa-72, 20018, San Sebastián, Spain.
Sagartzazu-Aizpurua M; Joxe Mari Korta R&D Center, Departamento de Química Orgánica-I, Universidad Del País Vasco UPV/EHU, Avda. Tolosa-72, 20018, San Sebastián, Spain.
Ferrón P; Miramoon Pharma S.L., Avda Tolosa-72, 20018, San Sebastián, Spain.
Aldanondo G; Instituto de Investigación Sanitaria Biodonostia, Grupo de Enfermedades Neuromusculares, Paseo Dr Begiristain s/n, 20014, San Sebastián, Spain; CIBERNED, Instituto de Salud Carlos III, 28031, Madrid, Spain.
Lasa-Fernández H; Instituto de Investigación Sanitaria Biodonostia, Grupo de Enfermedades Neuromusculares, Paseo Dr Begiristain s/n, 20014, San Sebastián, Spain; CIBERNED, Instituto de Salud Carlos III, 28031, Madrid, Spain; Grupo de Neurosciencias, Departamentos de Pediatría y Neurociencias, Universidad Del País Vasco UPV/EHU, Hospital Donostia, Paseo Dr Begiristain S/n, 20014, San Sebastián, Spain.
Marco-Moreno P; Instituto de Investigación Sanitaria Biodonostia, Grupo de Enfermedades Neuromusculares, Paseo Dr Begiristain s/n, 20014, San Sebastián, Spain; CIBERNED, Instituto de Salud Carlos III, 28031, Madrid, Spain.
Dadie N; Grupo de Neurosciencias, Departamentos de Pediatría y Neurociencias, Universidad Del País Vasco UPV/EHU, Hospital Donostia, Paseo Dr Begiristain S/n, 20014, San Sebastián, Spain.
López de Munain A; Instituto de Investigación Sanitaria Biodonostia, Grupo de Enfermedades Neuromusculares, Paseo Dr Begiristain s/n, 20014, San Sebastián, Spain; CIBERNED, Instituto de Salud Carlos III, 28031, Madrid, Spain; Grupo de Neurosciencias, Departamentos de Pediatría y Neurociencias, Universidad Del País Vasco UPV/EHU, Hospital Donostia, Paseo Dr Begiristain S/n, 20014, San Sebastián, Spain.
Vallejo-Illarramendi A; Instituto de Investigación Sanitaria Biodonostia, Grupo de Enfermedades Neuromusculares, Paseo Dr Begiristain s/n, 20014, San Sebastián, Spain; CIBERNED, Instituto de Salud Carlos III, 28031, Madrid, Spain; Grupo de Neurosciencias, Departamentos de Pediatría y Neurociencias, Universidad Del País Vasco UPV/EHU, Hospital Donostia, Paseo Dr Begiristain S/n, 20014, San Sebastián, Spain. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113160. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Calcium/*metabolism
Muscle, Skeletal/*drug effects
Tacrolimus Binding Protein 1A/*metabolism
Triazoles/*pharmacology
Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Molecular Structure ; Muscle, Skeletal/metabolism ; Oxidative Stress/drug effects ; Ryanodine Receptor Calcium Release Channel/chemistry ; Ryanodine Receptor Calcium Release Channel/metabolism ; Structure-Activity Relationship ; Tacrolimus Binding Protein 1A/chemistry ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and preliminary anticancer evaluation of new triazole bisphosphonate-based isoprenoid biosynthesis inhibitors.
Autorzy :
Legigan T; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France. Electronic address: .
Migianu-Griffoni E; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France.
Redouane MA; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France.
Descamps A; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France.
Deschamp J; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France.
Gager O; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France.
Monteil M; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France.
Barbault F; Université de Paris, ITODYS, CNRS, F-75006, Paris, France.
Lecouvey M; Université Sorbonne Paris Nord, UMR-CNRS 7244, Laboratoire Chimie, Structures, Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), équipe Chimie Bioorganique et Synthèse, 1 rue de Chablis, 93000, Bobigny, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 15; Vol. 214, pp. 113241. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Diphosphonates/*pharmacology
Terpenes/*antagonists & inhibitors
Triazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Diphosphonates/chemical synthesis ; Diphosphonates/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Terpenes/metabolism ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice.
Autorzy :
Zheng Y; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230032, Anhui, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.
Zhang YL; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.
Li Z; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.
Shi W; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.
Ji YR; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.
Guo YH; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China.
Huang C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China.
Sun GP; Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230032, Anhui, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China. Electronic address: .
Li J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University, Hefei, 230032, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, 230032, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113162. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Hesperidin/*pharmacology
Inflammation/*drug therapy
Liver/*drug effects
Triazoles/*pharmacology
Animals ; Carbon Tetrachloride ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Hesperidin/chemical synthesis ; Hesperidin/chemistry ; Inflammation/metabolism ; Inflammation/pathology ; Liver/injuries ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Nitric Oxide/analysis ; Nitric Oxide/biosynthesis ; RAW 264.7 Cells ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach.
Autorzy :
Xu M; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.; Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Zhao C; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.; Shenzhen Cell Inspire Therapeutics Co., Ltd., Shenzhen 518101, China.
Zhu B; Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Wang L; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Zhou H; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Yan D; Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Gu Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Xu J; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.; School of Biotechnology and Health Sciences, Wuyi University, 99 Yingbin Road, Jiangmen 529020, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Feb 25; Vol. 64 (4), pp. 2010-2023. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
HSP90 Heat-Shock Proteins/*antagonists & inhibitors
Nasopharyngeal Carcinoma/*drug therapy
Nasopharyngeal Neoplasms/*drug therapy
Triazoles/*therapeutic use
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Cell Line, Tumor ; Databases, Chemical ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Male ; Mice, Nude ; Molecular Dynamics Simulation ; Protein Binding ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/therapeutic use ; Triazoles/chemical synthesis ; Triazoles/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1,2,3-triazoles.
Autorzy :
Kumar S; Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
Sharma B; Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
Mehra V; Department of Chemistry, Hindu College, Amritsar, Punjab, 143001, India.
Kumar V; Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, Punjab, India. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 113069. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Antiparasitic Agents/*pharmacology
Triazoles/*pharmacology
Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antiparasitic Agents/chemical synthesis ; Antiparasitic Agents/chemistry ; Humans ; Molecular Structure ; Triazoles/chemical synthesis ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors.
Autorzy :
Ammazzalorso A; Unit of Medicinal Chemistry, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy. Electronic address: .
Gallorini M; Unit of Anatomy, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy.
Fantacuzzi M; Unit of Medicinal Chemistry, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy.
Gambacorta N; Unit of Medicinal Chemistry, Department of Farmacia-Scienze Del Farmaco, 'A. Moro' University, Bari, Italy.
De Filippis B; Unit of Medicinal Chemistry, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy.
Giampietro L; Unit of Medicinal Chemistry, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy.
Maccallini C; Unit of Medicinal Chemistry, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy.
Nicolotti O; Unit of Medicinal Chemistry, Department of Farmacia-Scienze Del Farmaco, 'A. Moro' University, Bari, Italy.
Cataldi A; Unit of Anatomy, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy.
Amoroso R; Unit of Medicinal Chemistry, Department of Pharmacy, 'G. D'Annunzio' University, Chieti, Italy.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 05; Vol. 211, pp. 113115. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aromatase Inhibitors/*chemical synthesis
Aromatase Inhibitors/*therapeutic use
Carbamates/*chemical synthesis
Carbamates/*therapeutic use
Imidazoles/*chemical synthesis
Imidazoles/*therapeutic use
Triazoles/*chemical synthesis
Triazoles/*therapeutic use
Aromatase Inhibitors/pharmacology ; Carbamates/pharmacology ; Drug Design ; Humans ; Imidazoles/pharmacology ; Molecular Structure ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
New 1,2,3-Triazole-Containing Hybrids as Antitumor Candidates: Design, Click Reaction Synthesis, DFT Calculations, and Molecular Docking Study.
Autorzy :
El Azab IH; Chemistry Department, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.; Chemistry Department, Faculty of Science, Aswan University, P.O. Box 81528 Aswan, Egypt.
El-Sheshtawy HS; Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafr ElSheikh 33516, Egypt.
Bakr RB; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, P.O. Box 2014 Sakaka, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Elkanzi NAA; Chemistry Department, Faculty of Science, Aswan University, P.O. Box 81528 Aswan, Egypt.; Chemistry Department, College of Science, Jouf University, P.O. Box 2014 Sakaka, Saudi Arabia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jan 29; Vol. 26 (3). Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cell Proliferation/*drug effects
Neoplasms/*drug therapy
Triazoles/*chemistry
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Click Chemistry ; Cycloaddition Reaction ; Density Functional Theory ; ErbB Receptors/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; Molecular Docking Simulation ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
Autorzy :
Peng Y; Biomedical Informatics Shared Resource, Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, United States.
Zhang Q; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 661 Hoes Lane West, Piscataway, New Jersey 08854, United States.
Welsh WJ; Biomedical Informatics Shared Resource, Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, New Jersey 08903, United States.; Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 661 Hoes Lane West, Piscataway, New Jersey 08854, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 890-904. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pain Management/*methods
Receptors, sigma/*antagonists & inhibitors
Triazoles/*chemistry
Animals ; Binding Sites ; Blood-Brain Barrier/metabolism ; Drug Design ; Guinea Pigs ; Half-Life ; Humans ; Microsomes, Liver/metabolism ; Molecular Dynamics Simulation ; Neuralgia/chemically induced ; Neuralgia/drug therapy ; Protein Structure, Tertiary ; Quantitative Structure-Activity Relationship ; Rats ; Receptors, sigma/metabolism ; Triazoles/metabolism ; Triazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Use of Novasomes as a Vesicular Carrier for Improving the Topical Delivery of Terconazole: In Vitro Characterization, In Vivo Assessment and Exploratory Clinical Experimentation.
Autorzy :
Mosallam S; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza, Egypt.
Ragaie MH; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al-Minya, Egypt.
Moftah NH; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al-Minya, Egypt.
Elshafeey AH; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abdelbary AA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, Egypt.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Jan 08; Vol. 16, pp. 119-132. Date of Electronic Publication: 2021 Jan 08 (Print Publication: 2021).
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Drug Delivery Systems*
Drug Carriers/*chemistry
Triazoles/*administration & dosage
Administration, Topical ; Animals ; Antifungal Agents/administration & dosage ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida albicans/drug effects ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Factor Analysis, Statistical ; Humans ; Infant ; Liposomes ; Male ; Microbial Sensitivity Tests ; Particle Size ; Rats ; Rats, Wistar ; Skin/drug effects ; Skin/microbiology ; Skin/pathology ; Skin Absorption/drug effects ; Static Electricity ; Suspensions ; Triazoles/pharmacology ; Triazoles/therapeutic use
Czasopismo naukowe
Tytuł :
Triazole fungicides in soil affect the yield of fruit, green biomass, and phenolics production of Solanum lycopersicum L.
Autorzy :
Jakl M; Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Agro-Environmental Chemistry and Plant Nutrition, Kamýcká 129, 165 00 Prague - Suchdol, Czech Republic.
Kovač I; Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Flemingovo nám. 542/2, 166 10 Prague 6, Czech Republic; Charles University, Faculty of Science, Department of Analytical Chemistry, Hlavova 2030, 128 43 Prague 2, Czech Republic.
Ćavar Zeljković S; Centre of the Region Haná for Biotechnological and Agricultural Research, Department of Genetic Resources for Vegetables, Medicinal and Special Plants, Crop Research Institute, Šlechtitelů 892/29, 783 71 Olomouc, Czech Republic; Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Department of Phytochemistry, Šlechtitelů 241/27, 783 71 Olomouc, Czech Republic.
Jaklová Dytrtová J; Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Flemingovo nám. 542/2, 166 10 Prague 6, Czech Republic; Charles University, Faculty of Physical Education and Sport, Department of Physiology and Biochemistry, José Martího 269/31, 162 52 Prague 6, Czech Republic. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jul 30; Vol. 351, pp. 129328. Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Biomass*
Fruit/*drug effects
Fruit/*growth & development
Lycopersicon esculentum/*drug effects
Phenols/*metabolism
Soil/*chemistry
Triazoles/*pharmacology
Biological Availability ; Fungicides, Industrial/analysis ; Fungicides, Industrial/pharmacology ; Lycopersicon esculentum/growth & development ; Lycopersicon esculentum/metabolism ; Triazoles/analysis
Czasopismo naukowe

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