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Wyszukujesz frazę ""Triazoles"" wg kryterium: Temat


Starter badań:

Tytuł:
Synthesis, molecular docking, and biological evaluation of novel 1,2,4-triazole-isatin derivatives as potential Mycobacterium tuberculosis shikimate kinase inhibitors.
Autorzy:
Dadlani VG; Department of Pharmaceutical Chemistry, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, India.
Chhabhaiya H; Department of Pharmaceutical Chemistry, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, India.
Somani RR; Department of Pharmaceutical Chemistry, D Y Patil University School of Pharmacy, Navi Mumbai, India.
Tripathi PK; Institute of Pharmaceutical Sciences, University of Lucknow, Lucknow, India.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2022 Aug; Vol. 100 (2), pp. 230-244. Date of Electronic Publication: 2022 Jun 06.
Typ publikacji:
Journal Article
MeSH Terms:
Antitubercular Agents*/chemistry
Antitubercular Agents*/pharmacology
Isatin*/chemistry
Isatin*/pharmacology
Mycobacterium tuberculosis*/drug effects
Phosphotransferases (Alcohol Group Acceptor)*/antagonists & inhibitors
Triazoles*/chemistry
Triazoles*/pharmacology
HEK293 Cells ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Shikimic Acid ; Structure-Activity Relationship ; Tuberculosis/drug therapy
Czasopismo naukowe
Tytuł:
Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group.
Autorzy:
Takemura H; Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Orimoto G; Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan. .
Kobayashi A; Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.; Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan. .
Hosoya T; Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Yoshida S; Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Aug 03; Vol. 20 (30), pp. 6007-6011. Date of Electronic Publication: 2022 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Click Chemistry*
Triazoles*
Amines ; Sulfhydryl Compounds
Czasopismo naukowe
Tytuł:
Mechanistic investigation of enolate/stabilized vinylogous carbanion-mediated organocatalytic azide (3 + 2) cycloaddition reactions for the synthesis of 1,2,3-triazoles.
Autorzy:
Chiavegatti Neto A; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
Soares KC; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
Santos MDS; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
Aímola TJ; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
Ferreira AG; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
Jardim GAM; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
Tormena CF; Institute of Chemistry, University of Campinas (UNICAMP), PO BOX 6154, Campinas, São Paulo CEP 13083-970, Brazil.
Paixão MW; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
Ferreira MAB; Department of Chemistry, Federal University of São Carlos - UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo, Brazil, 13565-905. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Aug 03; Vol. 20 (30), pp. 6019-6026. Date of Electronic Publication: 2022 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Azides*/chemistry
Triazoles*/chemistry
Anions ; Carboxylic Acids ; Catalysis ; Cycloaddition Reaction ; Metals/chemistry
Czasopismo naukowe
Tytuł:
Cyclometalated iridium(III) complex of a 1,2,3-triazole-based ligand for highly selective sensing of pyrophosphate ion.
Autorzy:
Rabha M; Centre for Advanced Studies, Department of Chemistry, North-Eastern Hill University, Shillong, Meghalaya 793022, India. .
Sen B; Centre for Advanced Studies, Department of Chemistry, North-Eastern Hill University, Shillong, Meghalaya 793022, India. .
Sheet SK; Centre for Advanced Studies, Department of Chemistry, North-Eastern Hill University, Shillong, Meghalaya 793022, India. .
Aguan K; Department of Biotechnology and Bioinformatics, North-Eastern Hill University, Shillong, Meghalaya 793022, India.
Khatua S; Centre for Advanced Studies, Department of Chemistry, North-Eastern Hill University, Shillong, Meghalaya 793022, India. .
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Źródło:
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2022 Aug 02; Vol. 51 (30), pp. 11372-11380. Date of Electronic Publication: 2022 Aug 02.
Typ publikacji:
Journal Article
MeSH Terms:
Iridium*/chemistry
Triazoles*/pharmacology
Diphosphates ; HeLa Cells ; Humans ; Ligands
Czasopismo naukowe
Tytuł:
Synthesis of novel immunomodulatory 1,4-disubstituted bis-1,2,3-triazoles by using click chemistry and their intracellular mechanism of action.
Autorzy:
Nural Y; Department of Analytical Chemistry, Faculty of Pharmacy, Mersin University, Mersin TR-33169, Turkey; Advanced Technology, Research and Application Center, Mersin University, TR-33343 Mersin, Turkey. Electronic address: .
Acar I; Department of Analytical Chemistry, Faculty of Pharmacy, Mersin University, Mersin TR-33169, Turkey.
Yetkin D; Advanced Technology, Research and Application Center, Mersin University, TR-33343 Mersin, Turkey.
Efeoglu C; Department of Analytical Chemistry, Faculty of Pharmacy, Mersin University, Mersin TR-33169, Turkey.
Seferoğlu Z; Department of Chemistry, Faculty of Science, Gazi University, TR-06560, Ankara, Turkey; Technological Dyes and Materials Application and Research Center (TEBAM), Gazi University, 06560 Ankara, Turkey.
Ayaz F; Department of Biotechnology, Faculty of Arts and Science, Mersin University, TR-33440, Mersin, Turkey; Mersin University Biotechnology Research and Application Center, Mersin University, TR-33440, Mersin, Turkey. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Aug 01; Vol. 69, pp. 128800. Date of Electronic Publication: 2022 May 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Click Chemistry*
Triazoles*/chemistry
Animals ; Anti-Inflammatory Agents/pharmacology ; Cytokines ; Mammals ; Phosphatidylinositol 3-Kinases ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Tytuł:
Domino assembly of dithiocarbamates via Cu-catalyzed denitrogenative thiolation of iodotriazole-based diazo precursors.
Autorzy:
Kotovshchikov YN; Chemistry Department, M. V. Lomonosov Moscow State University, Leninskiye Gory 1/3, Moscow 119991, Russia. .
Sultanov RH; Chemistry Department, M. V. Lomonosov Moscow State University, Leninskiye Gory 1/3, Moscow 119991, Russia. .
Latyshev GV; Chemistry Department, M. V. Lomonosov Moscow State University, Leninskiye Gory 1/3, Moscow 119991, Russia. .
Lukashev NV; Chemistry Department, M. V. Lomonosov Moscow State University, Leninskiye Gory 1/3, Moscow 119991, Russia. .
Beletskaya IP; Chemistry Department, M. V. Lomonosov Moscow State University, Leninskiye Gory 1/3, Moscow 119991, Russia. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Jul 27; Vol. 20 (29), pp. 5764-5770. Date of Electronic Publication: 2022 Jul 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amines*
Triazoles*
Benzoxazoles ; Catalysis ; Copper
Czasopismo naukowe
Tytuł:
The Impact of a 1,2,3-Triazole Motif on the Photophysical Behavior of Non-K Tetrasubstituted Pyrene with a Substitution Pattern Providing the Long Axial Symmetry.
Autorzy:
Zych D; Faculty of Chemistry, University of Opole, Oleska 48, 45-052 Opole, Poland.
Slodek A; Institute of Chemistry, Faculty of Science and Technology, University of Silesia, Szkolna 9, 40-006 Katowice, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jul 05; Vol. 27 (13). Date of Electronic Publication: 2022 Jul 05.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrenes*/chemistry
Triazoles*/chemistry
Pyrazoles ; Pyridines
Czasopismo naukowe
Tytuł:
Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration.
Autorzy:
Woerde DJ; William R Pritchard Veterinary Medical Teaching Hospital, University of California-Davis, Davis, California, USA.
Wittenburg LA; Department of Veterinary Surgical and Radiological Sciences, University of California-Davis, Davis, California, USA.
Dear JD; Department of Veterinary Medicine and Epidemiology, University of California-Davis, Davis, California, USA.
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Źródło:
Journal of veterinary internal medicine [J Vet Intern Med] 2022 Jul; Vol. 36 (4), pp. 1422-1429. Date of Electronic Publication: 2022 May 26.
Typ publikacji:
Journal Article
MeSH Terms:
Nitriles*/pharmacokinetics
Triazoles*
Administration, Intravenous/veterinary ; Administration, Oral ; Animals ; Area Under Curve ; Biological Availability ; Cats ; Half-Life ; Humans ; Pyridines/pharmacokinetics
Czasopismo naukowe
Tytuł:
Co-Binding of JQ1 and Venetoclax Exhibited Synergetic Inhibitory Effect for Cancer Therapy; Potential Line of Treatment for the Waldenström Macroglobulinemia Lymphoma.
Autorzy:
Elamin G; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
Aljoundi A; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
Soliman MES; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.
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Źródło:
Chemistry & biodiversity [Chem Biodivers] 2022 Jul; Vol. 19 (7), pp. e202100845. Date of Electronic Publication: 2022 Jun 08.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Azepines*/pharmacology
Bridged Bicyclo Compounds, Heterocyclic*/pharmacology
Lymphoma*/drug therapy
Sulfonamides*/pharmacology
Triazoles*/pharmacology
Waldenstrom Macroglobulinemia*/drug therapy
Waldenstrom Macroglobulinemia*/metabolism
Waldenstrom Macroglobulinemia*/pathology
Humans ; Proto-Oncogene Proteins c-bcl-2
Czasopismo naukowe
Tytuł:
Exposure-response relationships for the efficacy and safety of filgotinib and its metabolite GS-829845 in subjects with rheumatoid arthritis based on phase 2 and phase 3 studies.
Autorzy:
Meng A; Gilead Sciences Inc, Foster City, CA, USA.
Anderson K; Gilead Sciences Inc, Foster City, CA, USA.
Nelson C; Gilead Sciences Inc, Foster City, CA, USA.
Ni L; Gilead Sciences Inc, Foster City, CA, USA.
Chuang SM; Gilead Sciences Inc, Foster City, CA, USA.
Bellanti F; Certara Inc, Princeton, NJ, USA.
Chang P; Certara Inc, Princeton, NJ, USA.
Comisar C; Certara Inc, Princeton, NJ, USA.
Kearney BP; Gilead Sciences Inc, Foster City, CA, USA.
Bartok B; Gilead Sciences Inc, Foster City, CA, USA.
Mathias A; Gilead Sciences Inc, Foster City, CA, USA.
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Źródło:
British journal of clinical pharmacology [Br J Clin Pharmacol] 2022 Jul; Vol. 88 (7), pp. 3211-3221. Date of Electronic Publication: 2022 Feb 14.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arthritis, Rheumatoid*/drug therapy
Pyridines*/adverse effects
Triazoles*/adverse effects
Antirheumatic Agents/adverse effects ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Humans ; Janus Kinase Inhibitors/adverse effects ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Horizontal Gene Transfer of Triazole Resistance in Aspergillus fumigatus.
Autorzy:
Morogovsky A; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Handelman M; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Abou Kandil A; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Shadkchan Y; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Osherov N; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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Źródło:
Microbiology spectrum [Microbiol Spectr] 2022 Jun 29; Vol. 10 (3), pp. e0111222. Date of Electronic Publication: 2022 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aspergillus fumigatus*/genetics
Triazoles*/pharmacology
Antifungal Agents/pharmacology ; Drug Resistance, Fungal/genetics ; Fungal Proteins/genetics ; Fungi ; Gene Transfer, Horizontal ; Humans ; Microbial Sensitivity Tests ; Voriconazole
Czasopismo naukowe
Tytuł:
Synthesis and Structure Elucidation of Novel Spirooxindole Linked to Ferrocene and Triazole Systems via [3 + 2] Cycloaddition Reaction.
Autorzy:
Altowyan MS; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Soliman SM; Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt.
Haukka M; Department of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014 Jyväskylä, Finland.
Al-Shaalan NH; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Alkharboush AA; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Barakat A; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 25; Vol. 27 (13). Date of Electronic Publication: 2022 Jun 25.
Typ publikacji:
Journal Article
MeSH Terms:
Triazoles*
Crystallography, X-Ray ; Cycloaddition Reaction ; Magnetic Resonance Spectroscopy ; Metallocenes
Czasopismo naukowe
Tytuł:
Discovery of Phenylcarbamoylazinane-1,2,4-Triazole Amides Derivatives as the Potential Inhibitors of Aldo-Keto Reductases (AKR1B1 & AKRB10): Potential Lead Molecules for Treatment of Colon Cancer.
Autorzy:
Saeed A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Ejaz SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Sarfraz M; College of Pharmacy, Al Ain Campus, Al Ain University, Al Ain P.O. Box 64141, United Arab Emirates.
Tamam N; Department of Physics, College of Science, Princess Nourah bint Abdulrahman University, P.O Box 84428, Riyadh 11671, Saudi Arabia.
Siddique F; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrköping, Sweden.; Department of Pharmacy, Royal Institute of Medical Sciences (RIMS), Multan 60000, Pakistan.
Riaz N; Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Qais FA; Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh 202002, UP, India.
Chtita S; Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Sidi Othmane, Casablanca BP7955, Morocco.
Iqbal J; Centre for Advanced Drug Research, Abbottabad Campus, COMSATS University Islamabad, Abbotabad 22060, Pakistan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 21; Vol. 27 (13). Date of Electronic Publication: 2022 Jun 21.
Typ publikacji:
Journal Article
MeSH Terms:
Aldo-Keto Reductases*/antagonists & inhibitors
Aldo-Keto Reductases*/metabolism
Amides*/pharmacology
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/enzymology
Triazoles*/pharmacology
Humans ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł:
Ion-Pairing Assemblies of Anion-Responsive π-Electronic Systems Bearing Triazole Moieties Introduced by Click Chemistry.
Autorzy:
Maeda H; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Japan.
Nishimura T; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Japan.
Haketa Y; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Japan.
Tanaka H; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Japan.
Fujita M; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Japan.
Yasuda N; Diffraction and Scattering Division, Japan Synchrotron Radiation Research Institute, Sayo 679-5198, Japan.
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Źródło:
The Journal of organic chemistry [J Org Chem] 2022 Jun 17; Vol. 87 (12), pp. 7818-7825. Date of Electronic Publication: 2022 Jun 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Click Chemistry*
Triazoles*
Anions/chemistry ; Azides ; Crystallography, X-Ray ; Electronics ; Pyrroles/chemistry
Czasopismo naukowe
Tytuł:
Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors.
Autorzy:
Brown T; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
Cao M; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
Zheng YG; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 11; Vol. 27 (12). Date of Electronic Publication: 2022 Jun 11.
Typ publikacji:
Journal Article
MeSH Terms:
Protein-Arginine N-Methyltransferases*
Triazoles*/pharmacology
Adenosine/pharmacology ; Arginine ; Cell Line, Tumor ; Enzyme Inhibitors/chemistry ; Molecular Docking Simulation ; S-Adenosylmethionine
Czasopismo naukowe
Tytuł:
Synthesis and Luminescent Properties of s -Tetrazine Derivatives Conjugated with the 4 H -1,2,4-Triazole Ring.
Autorzy:
Maj A; Department of Chemical Organic Technology and Petrochemistry, The Silesian University of Technology, Krzywoustego 4, PL-44100 Gliwice, Poland.
Kudelko A; Department of Chemical Organic Technology and Petrochemistry, The Silesian University of Technology, Krzywoustego 4, PL-44100 Gliwice, Poland.
Świątkowski M; Institute of General and Ecological Chemistry, Lodz University of Technology, Zeromskiego 116, PL-90924 Lodz, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 06; Vol. 27 (11). Date of Electronic Publication: 2022 Jun 06.
Typ publikacji:
Journal Article
MeSH Terms:
Luminescence*
Triazoles*/chemistry
Aza Compounds/*chemical synthesis
Benzene Derivatives/*chemical synthesis
Aza Compounds/chemistry ; Benzene Derivatives/chemistry ; Electrons
Czasopismo naukowe
Tytuł:
Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.
Autorzy:
Hao Y; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Shao H; School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Qu Z; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Li J; Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Shi Y; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Zhang W; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Yu J; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Fu P; Department of Pharmacy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address: .
Zhuang C; School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, Shanghai, 200433, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jun 05; Vol. 236, pp. 114345. Date of Electronic Publication: 2022 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor-Interacting Protein Serine-Threonine Kinases*
Triazoles*/pharmacology
Apoptosis ; Cell Death ; Necroptosis
Czasopismo naukowe
Tytuł:
Telescoped Oxidation and Cycloaddition of Urazoles to Access Diazacyclobutenes.
Autorzy:
Miller BA; Department of Chemistry, Clemson University, Clemson, South Carolina 29631, United States.
Narangoda CJ; Department of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda-10250, Sri Lanka.
Johnson TL; School of Medicine-Greenville, University of South Carolina, Greenville, South Carolina 29605, United States.
Barata RD; Department of Chemistry, Clemson University, Clemson, South Carolina 29631, United States.
Belue F; Department of Chemistry, Clemson University, Clemson, South Carolina 29631, United States.
Solomon EE; Department of Chemistry, Clemson University, Clemson, South Carolina 29631, United States.
Bragg AA; Department of Chemistry, Clemson University, Clemson, South Carolina 29631, United States.
Whitehead DC; Department of Chemistry, Clemson University, Clemson, South Carolina 29631, United States.; Eukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina 29634, United States.
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Źródło:
The Journal of organic chemistry [J Org Chem] 2022 Jun 03; Vol. 87 (11), pp. 7494-7500. Date of Electronic Publication: 2022 May 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Triazoles*/chemistry
Cyclization ; Cycloaddition Reaction ; Molecular Structure
Czasopismo naukowe
Tytuł:
Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Isavuconazonium Sulfate in Healthy Adult Japanese Subjects.
Autorzy:
Shirae S; Development Planning, Clinical Development Center, Asahi Kasei Pharma Corporation, Tokyo, Japan.
Ose A; Development Planning, Clinical Development Center, Asahi Kasei Pharma Corporation, Tokyo, Japan.
Kumagai Y; Kitasato University Hospital, Kanagawa, Japan.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Jun; Vol. 11 (6), pp. 744-753. Date of Electronic Publication: 2022 Feb 21.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Nitriles*
Triazoles*
Adult ; Humans ; Japan ; Pyridines/adverse effects
Czasopismo naukowe
Tytuł:
Novel Hybrid 1,2,4- and 1,2,3-Triazoles Targeting Mycobacterium Tuberculosis Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Molecular Docking.
Autorzy:
El Sawy MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University, Alexandria 21311, Egypt.
Elshatanofy MM; Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.
El Kilany Y; Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.
Kandeel K; Department of Biochemistry, Faculty of Science, Alexandria University, Moharam Beik, Alexandria 21547, Egypt.
Elwakil BH; Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria 21311, Egypt.
Hagar M; Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.
Aouad MR; Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia.
Albelwi FF; Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia.
Rezki N; Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia.
Jaremko M; Smart-Health Initiative (SHI) and Red Sea Research Center (RSRC), Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), P.O. Box 4700, Thuwal 23955-6900, Saudi Arabia.
El Ashry ESH; Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Apr 24; Vol. 23 (9). Date of Electronic Publication: 2022 Apr 24.
Typ publikacji:
Journal Article
MeSH Terms:
Bacterial Proteins*/antagonists & inhibitors
Bacterial Proteins*/metabolism
Mycobacterium tuberculosis*/metabolism
Oxidoreductases*/antagonists & inhibitors
Oxidoreductases*/metabolism
Triazoles*/metabolism
Triazoles*/pharmacology
Tuberculosis*
Acyl Carrier Protein/metabolism ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Structure-Activity Relationship
Czasopismo naukowe

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