Temat: "Triazoles" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Synthesis, Docking, and Machine Learning Studies of Some Novel Quinolinesulfonamides-Triazole Hybrids with Anticancer Activity.
Autorzy:: Marciniec K; Department of Organic Chemistry, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Nowakowska J; Department of Organic Chemistry, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Chrobak E; Department of Organic Chemistry, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Bębenek E; Department of Organic Chemistry, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Latocha M; Department of Molecular Biology, Jagiellońska 4, 41-200 Sosnowiec, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2024 Jul 02; Vol. 29 (13). Date of Electronic Publication: 2024 Jul 02.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Molecular Docking Simulation*
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/chemical synthesis
Sulfonamides*/chemistry
Sulfonamides*/pharmacology
Sulfonamides*/chemical synthesis
Machine Learning*
Quinolines*/chemistry
Quinolines*/pharmacology
Quinolines*/chemical synthesis
Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Structure-Activity Relationship ; Molecular Dynamics Simulation ; Molecular Structure

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Skocz do pozycji: 2.

Tytuł:: 1,5-disubstituted 1,2,3-triazolylated carbohydrates and nucleosides.
Autorzy:: Pathak T; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, West Bengal, India. Electronic address: .
Bose A; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721 302, West Bengal, India.; Pokaż więcej
Źródło:: Carbohydrate research [Carbohydr Res] 2024 Jul; Vol. 541, pp. 109126. Date of Electronic Publication: 2024 Apr 30.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Triazoles*/chemistry
Triazoles*/chemical synthesis
Nucleosides*/chemistry
Nucleosides*/chemical synthesis
Carbohydrates*/chemistry
Click Chemistry ; Catalysis ; Molecular Structure

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Skocz do pozycji: 3.

Tytuł:: Discovery of 1,2,3-triazole-based pleuromutilin derivatives as potent gram-positive antibacterial agents.
Autorzy:: Zhang J; School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Yuhua Road 70, Shijiazhuang 050080, PR China.
Chen S; Hebei Provincial Key Laboratory of Photoelectric Control on Surface and Interface, and College of Science, Hebei University of Science and Technology, Yuhua Road 70, Shijiazhuang 050080, PR China. Electronic address: sjz_.
Liu X; Hebei Provincial Key Laboratory of Photoelectric Control on Surface and Interface, and College of Science, Hebei University of Science and Technology, Yuhua Road 70, Shijiazhuang 050080, PR China.
Yu X; Hebei Provincial Key Laboratory of Photoelectric Control on Surface and Interface, and College of Science, Hebei University of Science and Technology, Yuhua Road 70, Shijiazhuang 050080, PR China.
Gu N; Hebei Provincial Key Laboratory of Photoelectric Control on Surface and Interface, and College of Science, Hebei University of Science and Technology, Yuhua Road 70, Shijiazhuang 050080, PR China. Electronic address: .
Li A; School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Yuhua Road 70, Shijiazhuang 050080, PR China. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 15; Vol. 110, pp. 129878. Date of Electronic Publication: 2024 Jul 06.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Bacterial Agents*/pharmacology
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/chemical synthesis
Pleuromutilins*
Polycyclic Compounds*/chemistry
Polycyclic Compounds*/pharmacology
Diterpenes*/pharmacology
Diterpenes*/chemistry
Diterpenes*/chemical synthesis
Microbial Sensitivity Tests*
Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Structure-Activity Relationship ; Gram-Positive Bacteria/drug effects ; Molecular Docking Simulation ; Molecular Structure ; Escherichia coli/drug effects ; Staphylococcus epidermidis/drug effects ; Staphylococcus aureus/drug effects ; Dose-Response Relationship, Drug ; Drug Discovery

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Skocz do pozycji: 4.

Tytuł:: Synthesis and antifungal evaluation of novel triazole derivatives bearing a pyrazole-methoxyl moiety.
Autorzy:: Hao Y; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China.
Wang R; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China.
Ni T; Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No.1239 Siping Road, Shanghai, 200072, China.
Monk BC; Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, 9016, New Zealand.
Tyndall JDA; School of Pharmacy, University of Otago, Dunedin, 9054, New Zealand.
Bao J; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China.
Wang M; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No.103 Wenhua Road, Shenyang, 110016, China.
Chi X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No.103 Wenhua Road, Shenyang, 110016, China.
Yu S; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China.
Jin Y; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China.
Zhang D; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China; Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No.1239 Siping Road, Shanghai, 200072, China. Electronic address: zdzhang_.
Yan L; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China. Electronic address: .
Xie F; School of Pharmacy, The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Naval Medical University, No.325 Guohe Road, Shanghai, 200433, China. Electronic address: .; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116637. Date of Electronic Publication: 2024 Jul 02.
Typ publikacji:: Journal Article
MeSH Terms:: Antifungal Agents*/pharmacology
Antifungal Agents*/chemical synthesis
Antifungal Agents*/chemistry
Microbial Sensitivity Tests*
Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Pyrazoles*/chemistry
Pyrazoles*/pharmacology
Pyrazoles*/chemical synthesis
Candida*/drug effects
Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Cryptococcus neoformans/drug effects ; Humans ; Drug Resistance, Fungal/drug effects ; Saccharomyces cerevisiae/drug effects ; Candida albicans/drug effects

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Skocz do pozycji: 5.

Tytuł:: Synthesis of thiazolidine-2,4-dione tethered 1,2,3-triazoles as α-amylase inhibitors: In vitro approach coupled with QSAR, molecular docking, molecular dynamics and ADMET studies.
Autorzy:: Singh R; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India; School of Chemistry, Indian Institutes of Science Education and Research, Thiruvananthapuram, Kerala, 695551, India.
Sindhu J; Department of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar, 125004, India.
Devi M; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India.
Kumar P; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India. Electronic address: .
Lal S; Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India.
Kumar A; Department of Pharmaceutical Sciences, GJUS&T, Hisar, -125001, India.
Singh D; Department of Chemistry, Maharshi Dayanand University, Rohtak, India, 124001.
Kumar H; Department of Chemistry, School of Basic Sciences, Central University Haryana, Mahendergarh, India.; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116623. Date of Electronic Publication: 2024 Jun 25.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Molecular Docking Simulation*
alpha-Amylases*/antagonists & inhibitors
alpha-Amylases*/metabolism
Molecular Dynamics Simulation*
Quantitative Structure-Activity Relationship*
Thiazolidinediones*/chemistry
Thiazolidinediones*/chemical synthesis
Thiazolidinediones*/pharmacology
Molecular Structure ; Dose-Response Relationship, Drug ; Humans

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Skocz do pozycji: 6.

Tytuł:: Structural modification strategies of triazoles in anticancer drug development.
Autorzy:: Guan Q; School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Gao Z; School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Chen Y; School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Guo C; School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Chen Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People's Republic of China.
Sun H; School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. Electronic address: .; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116578. Date of Electronic Publication: 2024 Jun 13.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemical synthesis
Drug Development*
Humans ; Molecular Structure ; Structure-Activity Relationship ; Neoplasms/drug therapy ; Neoplasms/pathology ; Animals ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects

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Skocz do pozycji: 7.

Tytuł:: Design, Synthesis, and Bioactivity Determination of Novel Malononitrile Derivatives Containing 1,2,3-Triazole.
Autorzy:: Wang S; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Zhao Z; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Wang Y; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Zheng H; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Zhang Q; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Zhang L; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Zhang J; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Lu H; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.
Dong Y; Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.; Pokaż więcej
Źródło:: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Sep 04; Vol. 72 (35), pp. 19274-19285. Date of Electronic Publication: 2024 Aug 26.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Fungicides, Industrial*/pharmacology
Fungicides, Industrial*/chemistry
Fungicides, Industrial*/chemical synthesis
Rhizoctonia*/drug effects
Nitriles*/chemistry
Nitriles*/pharmacology
Botrytis*/drug effects
Drug Design ; Structure-Activity Relationship ; Plant Diseases/microbiology ; Molecular Structure
SCR Organism:: Botrytis cinerea; Rhizoctonia solani

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Skocz do pozycji: 8.

Tytuł:: Novel Insights into Stereoselective Reproductive Toxicity Induced by Mefentrifluconazole in Earthworms ( Eisenia fetida ): First Report of Estrogenic Effects.
Autorzy:: Yao X; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Lv H; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Wang Q; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Ding J; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Kong W; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Mu B; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Dong C; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Hu X; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Sun H; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Li X; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.
Wang J; Key Laboratory of Agricultural Environment in Universities of Shandong, College of Resources and Environment, Shandong Agricultural University, Tai'an 271018, China.; Pokaż więcej
Źródło:: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Sep 04; Vol. 72 (35), pp. 19304-19311. Date of Electronic Publication: 2024 Jul 16.
Typ publikacji:: Journal Article
MeSH Terms:: Oligochaeta*/drug effects
Oligochaeta*/genetics
Oligochaeta*/metabolism
Reproduction*/drug effects
Fungicides, Industrial*/toxicity
Fungicides, Industrial*/chemistry
Triazoles*/toxicity
Triazoles*/chemistry
Animals ; Stereoisomerism ; Soil Pollutants/toxicity ; Soil Pollutants/chemistry ; Female ; Receptors, Estrogen/metabolism ; Receptors, Estrogen/genetics ; Estrogens/metabolism ; Estrogens/toxicity

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Skocz do pozycji: 9.

Tytuł:: Design, synthesis, and antiproliferative activity of new indole/1,2,4-triazole/chalcone hybrids as EGFR and/or c-MET inhibitors.
Autorzy:: Mahmoud E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Abdelhamid D; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.; Raabe College of Pharmacy, Ohio Northern University, Ohio, USA.
Youssif BGM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Gomaa HAM; Pharmacology Department, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.
Hayallah AM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sphinx University, New-Assiut, Egypt.
Abdel-Aziz M; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.; Pokaż więcej
Źródło:: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep; Vol. 357 (9), pp. e2300562. Date of Electronic Publication: 2024 Jun 21.
Typ publikacji:: Journal Article
MeSH Terms:: ErbB Receptors*/antagonists & inhibitors
ErbB Receptors*/metabolism
Proto-Oncogene Proteins c-met*/antagonists & inhibitors
Proto-Oncogene Proteins c-met*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Cell Proliferation*/drug effects
Triazoles*/pharmacology
Triazoles*/chemistry
Triazoles*/chemical synthesis
Drug Design*
Protein Kinase Inhibitors*/pharmacology
Protein Kinase Inhibitors*/chemical synthesis
Protein Kinase Inhibitors*/chemistry
Drug Screening Assays, Antitumor*
Indoles*/pharmacology
Indoles*/chemistry
Indoles*/chemical synthesis
Humans ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Cell Line, Tumor ; Chalcones/pharmacology ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Chalcone/pharmacology ; Chalcone/chemistry ; Chalcone/chemical synthesis

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Skocz do pozycji: 10.

Tytuł:: Click-chemistry-inspired synthesis of new series of 1,2,3-triazole fused chromene with glucose triazole conjugates: Antibacterial activity assessment with molecular docking evaluation.
Autorzy:: Ahemad MA; Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack, 753003, Odisha, India.
Patra A; Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack, 753003, Odisha, India.
Muduli L; Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack, 753003, Odisha, India.
Nayak S; Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack, 753003, Odisha, India. Electronic address: .
Mohapatra S; Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack, 753003, Odisha, India.
Panda J; Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack, 753003, Odisha, India.
Sahoo CR; ICMR-Regional Medical Research Centre, Department of Health Research, Ministry of Health & Family Welfare, Govt. of India, Bhubaneswar, 751023, Odisha, India.; Pokaż więcej
Źródło:: Carbohydrate research [Carbohydr Res] 2024 Sep; Vol. 543, pp. 109222. Date of Electronic Publication: 2024 Jul 30.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Anti-Bacterial Agents*/pharmacology
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/chemical synthesis
Molecular Docking Simulation*
Escherichia coli*/drug effects
Click Chemistry*
Staphylococcus aureus*/drug effects
Microbial Sensitivity Tests*
Benzopyrans*/chemistry
Benzopyrans*/pharmacology
Benzopyrans*/chemical synthesis
Glucose*/chemistry
Glucose*/analogs & derivatives
Structure-Activity Relationship ; Molecular Structure ; DNA Gyrase/metabolism ; DNA Gyrase/chemistry ; Humans

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Skocz do pozycji: 11.

Tytuł:: Discovery of cinnamamide/ester triazole hybrids as potential treatment for Alzheimer's disease.
Autorzy:: Tan LJ; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Lei WJ; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Liu MM; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Cai ZD; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Jiang HL; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Liu R; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .
Li ZR; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107584. Date of Electronic Publication: 2024 Jun 22.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Cinnamates*/chemistry
Cinnamates*/pharmacology
Cinnamates*/chemical synthesis
Amyloid beta-Peptides*/metabolism
Amyloid beta-Peptides*/antagonists & inhibitors
Animals ; Humans ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Esters/chemistry ; Esters/pharmacology ; Esters/chemical synthesis ; Dose-Response Relationship, Drug ; Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemical synthesis ; Drug Discovery ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/chemical synthesis ; Peptide Fragments/metabolism ; Peptide Fragments/antagonists & inhibitors ; Male

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Skocz do pozycji: 12.

Tytuł:: Triazole derivatives inhibit the VOR complex-mediated nuclear transport of extracellular particles: Potential application in cancer and HIV-1 infection.
Autorzy:: Carbone D; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy. Electronic address: .
Santos MF; Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA. Electronic address: .
Corbeil D; Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany; Tissue Engineering Laboratories, Medizinische Fakultät der Technischen Universität Dresden, Dresden, Germany. Electronic address: .
Vistoli G; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy. Electronic address: .
Parrino B; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy. Electronic address: .
Karbanová J; Biotechnology Center (BIOTEC) and Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany; Tissue Engineering Laboratories, Medizinische Fakultät der Technischen Universität Dresden, Dresden, Germany. Electronic address: .
Cascioferro S; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy. Electronic address: .
Pecoraro C; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy. Electronic address: .
Bauson J; Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA. Electronic address: .
Eliwat W; Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA. Electronic address: .
Aalam F; Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA. Electronic address: .
Cirrincione G; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy. Electronic address: .
Lorico A; Touro University Nevada College of Osteopathic Medicine, Henderson, NV, USA. Electronic address: .
Diana P; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107589. Date of Electronic Publication: 2024 Jun 23.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
HIV Infections*/drug therapy
HIV Infections*/metabolism
Humans ; Structure-Activity Relationship ; Molecular Structure ; HIV-1/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Dose-Response Relationship, Drug ; Active Transport, Cell Nucleus/drug effects ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/drug effects ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology

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Skocz do pozycji: 13.

Tytuł:: Design, synthesis and anti-inflammatory assessment of certain substituted 1,2,4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors.
Autorzy:: Abo-Elmagd MI; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt.
Hassan RM; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt.
Aboutabl ME; Medicinal and Pharmaceutical Chemistry Department, Pharmacology Group, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt.
Amin KM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
El-Azzouny AA; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt.
Aboul-Enein MN; Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, Dokki, Giza, Egypt. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107577. Date of Electronic Publication: 2024 Jun 18.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Drug Design*
Cyclooxygenase 1*/metabolism
Cyclooxygenase 2*/metabolism
Anti-Inflammatory Agents, Non-Steroidal*/pharmacology
Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal*/chemistry
Edema*/drug therapy
Edema*/chemically induced
Animals ; Structure-Activity Relationship ; Rats ; Molecular Structure ; Tetrahydroisoquinolines/pharmacology ; Tetrahydroisoquinolines/chemistry ; Tetrahydroisoquinolines/chemical synthesis ; Cyclooxygenase Inhibitors/pharmacology ; Cyclooxygenase Inhibitors/chemical synthesis ; Cyclooxygenase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Molecular Docking Simulation ; Male ; Carrageenan ; Rats, Wistar ; Humans ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy

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Skocz do pozycji: 14.

Tytuł:: BRD4 degraders may effectively counteract therapeutic resistance of leukemic stem cells in AML and ALL.
Autorzy:: Bauer K; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Hauswirth A; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Gleixner KV; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Greiner G; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Ihr Labor, Medical Diagnostic Laboratories, Vienna, Austria.
Thaler J; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Bettelheim P; Labor Europaplatz, Linz, Austria.
Filik Y; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Koller E; Third Medical Department for Hematology and Oncology, Hanusch Hospital Vienna, Vienna, Austria.
Hoermann G; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; MLL Munich Leukemia Laboratory, Munich, Germany.
Staber PB; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Sperr WR; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Keil F; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Third Medical Department for Hematology and Oncology, Hanusch Hospital Vienna, Vienna, Austria.
Valent P; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.; Pokaż więcej
Źródło:: American journal of hematology [Am J Hematol] 2024 Sep; Vol. 99 (9), pp. 1721-1731. Date of Electronic Publication: 2024 Jun 01.
Typ publikacji:: Journal Article
MeSH Terms:: Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/pathology
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/genetics
Transcription Factors*
Triazoles*/pharmacology
Triazoles*/therapeutic use
Azepines*/pharmacology
Azepines*/therapeutic use
Drug Resistance, Neoplasm*/drug effects
Cell Cycle Proteins*/antagonists & inhibitors
Neoplastic Stem Cells*/drug effects
Neoplastic Stem Cells*/metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/pathology
Humans ; Cell Line, Tumor ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Pyrazines/pharmacology ; Pyrazines/therapeutic use ; Drug Synergism ; Pyridazines/pharmacology ; Pyridazines/therapeutic use ; Bromodomain Containing Proteins ; Aniline Compounds

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Skocz do pozycji: 15.

Tytuł:: Facile benzothiazole-triazole based thiazole derivatives as novel thymidine phosphorylase and α-glucosidase inhibitors: Experimental and computational approaches.
Autorzy:: Khan S; Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan. Electronic address: .
Hussain R; Department of Chemistry, Hazara University, Mansehra 21120, Pakistan. Electronic address: .
Khan Y; Department of Chemistry, COMSATS University Islamabad campus, Islamabad 45550, Pakistan.
Iqbal T; Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan.
Ullah F; Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan.
Felemban S; Department of Chemistry, Faculty of Applied Science, University College-Al Leith, University of Umm Al-Qura, Makkah 21955, Saudi Arabia.
Khowdiary MM; Department of Chemistry, Faculty of Applied Science, University College-Al Leith, University of Umm Al-Qura, Makkah 21955, Saudi Arabia.; Pokaż więcej
Źródło:: Enzyme and microbial technology [Enzyme Microb Technol] 2024 Sep; Vol. 179, pp. 110470. Date of Electronic Publication: 2024 Jun 13.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Benzothiazoles*/chemistry
Glycoside Hydrolase Inhibitors*/chemistry
Glycoside Hydrolase Inhibitors*/pharmacology
Glycoside Hydrolase Inhibitors*/chemical synthesis
Molecular Docking Simulation*
Thymidine Phosphorylase*/antagonists & inhibitors
Thymidine Phosphorylase*/metabolism
alpha-Glucosidases*/metabolism
alpha-Glucosidases*/chemistry
Structure-Activity Relationship ; Thiazoles/chemistry ; Thiazoles/pharmacology ; Thiazoles/metabolism ; Humans ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemical synthesis

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Skocz do pozycji: 16.

Tytuł:: Individualized regimen of Posaconazole oral suspension in Chinese HSCT patients based on population pharmacokinetic model.
Autorzy:: Shu YS; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Dong ZH; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Yang YL; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Li SW; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Yi QY; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Wang P; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Shi YP; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Zhang YY; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China.
Shi HY; Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Pediatric Drug Clinical Evaluation and R&D Research Center of Engineering Technology, Jinan, 250014, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Aug 31; Vol. 14 (1), pp. 20288. Date of Electronic Publication: 2024 Aug 31.
Typ publikacji:: Journal Article
MeSH Terms:: Hematopoietic Stem Cell Transplantation*
Triazoles*/pharmacokinetics
Triazoles*/administration & dosage
Antifungal Agents*/pharmacokinetics
Antifungal Agents*/administration & dosage
Antifungal Agents*/therapeutic use
Humans ; Male ; Female ; Adult ; Middle Aged ; Retrospective Studies ; Adolescent ; Young Adult ; Administration, Oral ; Models, Biological ; China ; Asian People ; Suspensions ; East Asian People

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Skocz do pozycji: 17.

Tytuł:: Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3 H -1,2,4-triazole-3-thione.
Autorzy:: Yoon DS; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Liu C; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Jalagam PR; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Feng J; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Wang W; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Swidorski JJ; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Xu L; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Hartz RA; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Nair SK; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Beno BR; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Panda M; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Ghosh K; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Kumar A; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Sale H; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Shah D; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.
Mathur A; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Ellsworth BA; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Cheng D; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Regueiro-Ren A; Research and Early Development, Bristol Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14184-14199. Date of Electronic Publication: 2024 Aug 05.
Typ publikacji:: Journal Article
MeSH Terms:: Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Triazoles*/pharmacokinetics
Galactose*/chemistry
Galactose*/metabolism
Galectin 3*/antagonists & inhibitors
Galectin 3*/metabolism
Animals ; Humans ; Mice ; Structure-Activity Relationship ; Crystallography, X-Ray ; Thiones/chemistry ; Thiones/pharmacology ; Thiones/chemical synthesis ; Thiones/pharmacokinetics ; Blood Proteins/metabolism ; Galectins/antagonists & inhibitors ; Galectins/metabolism ; Models, Molecular

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Skocz do pozycji: 18.

Tytuł:: Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.
Autorzy:: Kim GR; School of Life Sciences, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Kim S; School of Life Sciences, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Kim YO; Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Republic of Korea.
Han X; Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Republic of Korea.
Nagel J; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53113, Germany.
Kim J; School of Life Sciences, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Song DI; Bioengineering, University of Pennsylvania, 3451 Walnut St, Philadelphia, Pennsylvania 19104, United States.
Müller CE; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53113, Germany.
Yoon MH; Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Republic of Korea.
Jin MS; School of Life Sciences, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Kim YC; School of Life Sciences, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14443-14465. Date of Electronic Publication: 2024 Aug 05.
Typ publikacji:: Journal Article
MeSH Terms:: Purinergic P2X Receptor Antagonists*/pharmacology
Purinergic P2X Receptor Antagonists*/chemistry
Purinergic P2X Receptor Antagonists*/chemical synthesis
Cryoelectron Microscopy*
Pyrimidines*/pharmacology
Pyrimidines*/chemistry
Pyrimidines*/chemical synthesis
Receptors, Purinergic P2X3*/metabolism
Triazoles*/pharmacology
Triazoles*/chemistry
Triazoles*/chemical synthesis
Animals ; Structure-Activity Relationship ; Rats ; Humans ; Allosteric Site ; Male ; Neuralgia/drug therapy ; Drug Discovery ; Rats, Sprague-Dawley

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Skocz do pozycji: 19.

Tytuł:: Insights into the Enantiomeric Uptake, Translocation, and Distribution of Triazole Chiral Pesticide Mefentrifluconazole in Wheat ( Triticum aestivum L. ).
Autorzy:: Liu L
Cheng Z
Wang P
Chen X
Chen Z; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Li J; Citrus Research Institute, Southwest University & Chinese Academy of Agricultural Sciences, Chongqing 400712, China.
Lu Y
Sun H; Pokaż więcej
Źródło:: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Aug 21; Vol. 72 (33), pp. 18401-18411. Date of Electronic Publication: 2024 Aug 02.
Typ publikacji:: Journal Article
MeSH Terms:: Triticum*/metabolism
Triticum*/chemistry
Triazoles*/chemistry
Triazoles*/metabolism
Fungicides, Industrial*/metabolism
Fungicides, Industrial*/chemistry
Stereoisomerism ; Biological Transport ; Molecular Docking Simulation ; Plant Roots/metabolism ; Plant Roots/chemistry

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Skocz do pozycji: 20.

Tytuł:: Synthesis of α-Hydroxy-1,2,3-Triazole-linked Sialyltransferase Inhibitors and Evaluation of Selectivity Towards ST3GAL1, ST6GAL1 and ST8SIA2.
Autorzy:: Szabo R; School of Chemistry & Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.
Dobie C; School of Chemistry & Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.; Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Montgomery AP; School of Chemistry & Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.
Steele H; School of Chemistry & Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.
Yu H; School of Chemistry & Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.; Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.; ARC Centre of Excellence in Quantum Biotechnology, University of Wollongong, Wollongong, NSW, Australia.
Skropeta D; School of Chemistry & Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.; Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.; Pokaż więcej
Źródło:: ChemMedChem [ChemMedChem] 2024 Aug 19; Vol. 19 (16), pp. e202400088. Date of Electronic Publication: 2024 Jul 01.
Typ publikacji:: Journal Article
MeSH Terms:: Sialyltransferases*/antagonists & inhibitors
Sialyltransferases*/metabolism
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/chemical synthesis
beta-Galactoside alpha-2,3-Sialyltransferase*
Triazoles*/chemistry
Triazoles*/pharmacology
Triazoles*/chemical synthesis
Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; beta-D-Galactoside alpha 2-6-Sialyltransferase ; Antigens, CD

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