Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Trichlormethiazide"" wg kryterium: Temat


Tytuł:
Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients.
Autorzy:
Hosaka M; a Department of Development Promotion, Clinical Research, Innovation and Education Center , Tohoku University Hospital , Sendai , Japan.
Inoue R; b Department of Medical Informatics , Tohoku University Graduate School of Medicine , Sendai , Japan.
Satoh M; c Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine , Tohoku Medical and Pharmaceutical University , Sendai , Japan.
Watabe D; d Department of Planning for Drug Development and Clinical Evaluation , Tohoku University Graduate School of Pharmaceutical Sciences , Sendai , Japan.; e Department of Pharmacy , National Cancer Center Hospital , Tokyo , Japan.
Hanazawa T; d Department of Planning for Drug Development and Clinical Evaluation , Tohoku University Graduate School of Pharmaceutical Sciences , Sendai , Japan.; f Japan Development and Medical Affairs , GlaxoSmithKline , Tokyo , Japan.
Ohkubo T; g Department of Hygiene and Public Health , Tohoku Institute for Management of BP, Teikyo University School of Medicine , Tokyo , Japan.
Asayama K; d Department of Planning for Drug Development and Clinical Evaluation , Tohoku University Graduate School of Pharmaceutical Sciences , Sendai , Japan.; g Department of Hygiene and Public Health , Tohoku Institute for Management of BP, Teikyo University School of Medicine , Tokyo , Japan.
Obara T; h Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization , Tohoku University , Sendai , Japan.; i Department of Pharmacy , Tohoku University Hospital , Sendai , Japan.
Imai Y; j Department of Planning for Drug Development and Clinical Evaluation, Tohoku Institute for Management of BP , Tohoku University Graduate School of Pharmaceutical Sciences , Sendai , Japan.
Pokaż więcej
Corporate Authors:
J-HOME-ALB Study group.
Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2018; Vol. 40 (5), pp. 468-475. Date of Electronic Publication: 2017 Nov 27.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Albuminuria/*drug therapy
Amlodipine/*therapeutic use
Antihypertensive Agents/*pharmacology
Biphenyl Compounds/*therapeutic use
Dihydropyridines/*therapeutic use
Essential Hypertension/*drug therapy
Nitrophenols/*therapeutic use
Tetrazoles/*therapeutic use
Trichlormethiazide/*therapeutic use
Aged ; Albuminuria/complications ; Albuminuria/urine ; Amlodipine/pharmacology ; Antihypertensive Agents/therapeutic use ; Biphenyl Compounds/pharmacology ; Blood Pressure/drug effects ; Blood Pressure Monitoring, Ambulatory ; Dihydropyridines/pharmacology ; Drug Therapy, Combination ; Essential Hypertension/complications ; Female ; Humans ; Irbesartan ; Male ; Middle Aged ; Nitrophenols/pharmacology ; Organophosphorus Compounds/pharmacology ; Organophosphorus Compounds/therapeutic use ; Tetrazoles/pharmacology ; Trichlormethiazide/pharmacology ; Urinalysis
Czasopismo naukowe
Tytuł:
The effect of trichlormethiazide in autosomal dominant polycystic kidney disease patients receiving tolvaptan: a randomized crossover controlled trial.
Autorzy:
Uchiyama K; Division of Endocrinology, Metabolism and Nephrology Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. .; Division of Nephrology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan. .
Kitayama C; Department of Nephrology, Japan Community Health Care Organization (JCHO) Sendai Hospital, Miyagi, 981-8501, Japan.
Yanai A; Department of Nephrology, Tokyo Shinagawa Hospital, Tokyo, 140-8522, Japan.
Ishibashi Y; Division of Nephrology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan.
Pokaż więcej
Źródło:
Scientific reports [Sci Rep] 2021 Sep 03; Vol. 11 (1), pp. 17666. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Antidiuretic Hormone Receptor Antagonists/*therapeutic use
Polycystic Kidney, Autosomal Dominant/*drug therapy
Sodium Chloride Symporter Inhibitors/*therapeutic use
Tolvaptan/*therapeutic use
Trichlormethiazide/*therapeutic use
Adult ; Aged ; Cross-Over Studies ; Drug Therapy, Combination ; Female ; Humans ; Kidney/physiopathology ; Male ; Middle Aged ; Osmolar Concentration ; Polycystic Kidney, Autosomal Dominant/physiopathology ; Quality of Life ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Comparison of Azelnidipine and Trichlormethiazide in Japanese Type 2 Diabetic Patients with Hypertension: The COAT Randomized Controlled Trial.
Autorzy:
Takihata M; Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Nakamura A; Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Kondo Y; Department of Endocrinology and Metabolism, Chigasaki Municipal Hospital, Chigasaki, Kanagawa, Japan.
Kawasaki S; Department of Endocrinology and Metabolism, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Kanagawa, Japan.
Kimura M; Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Terauchi Y; Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2015 May 04; Vol. 10 (5), pp. e0125519. Date of Electronic Publication: 2015 May 04 (Print Publication: 2015).
Typ publikacji:
Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Azetidinecarboxylic Acid/*analogs & derivatives
Calcium Channel Blockers/*therapeutic use
Diabetes Mellitus, Type 2/*complications
Diabetes Mellitus, Type 2/*drug therapy
Dihydropyridines/*therapeutic use
Diuretics/*therapeutic use
Hypertension/*complications
Hypertension/*drug therapy
Trichlormethiazide/*therapeutic use
Aged ; Azetidinecarboxylic Acid/administration & dosage ; Azetidinecarboxylic Acid/adverse effects ; Azetidinecarboxylic Acid/therapeutic use ; Blood Pressure/drug effects ; Calcium Channel Blockers/administration & dosage ; Calcium Channel Blockers/adverse effects ; Dihydropyridines/administration & dosage ; Dihydropyridines/adverse effects ; Diuretics/administration & dosage ; Diuretics/adverse effects ; Female ; Humans ; Japan ; Male ; Middle Aged ; Risk Factors ; Treatment Outcome ; Trichlormethiazide/administration & dosage ; Trichlormethiazide/adverse effects
Czasopismo naukowe
Tytuł:
Synthesis and Chemistry of Organic Geminal Di- and Triazides.
Autorzy:
Häring AP; Organic Chemistry, Bergische Universität Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany. .
Kirsch SF; Organic Chemistry, Bergische Universität Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany. .
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2015 Nov 06; Vol. 20 (11), pp. 20042-62. Date of Electronic Publication: 2015 Nov 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Chemistry Techniques, Synthetic*
Chemistry, Organic*
Azides/*chemistry
Trichlormethiazide/*chemistry
Azides/chemical synthesis ; Trichlormethiazide/chemical synthesis
Czasopismo naukowe
Tytuł:
Combining irbesartan and trichlormethiazide enhances blood pressure reduction via inhibition of sympathetic activity without adverse effects on metabolism in hypertensive rats with metabolic syndrome.
Autorzy:
Nishihara M; Department of Cardiovascular Medicine and.
Hirooka Y
Sunagawa K
Pokaż więcej
Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2015; Vol. 37 (1), pp. 33-8. Date of Electronic Publication: 2014 Mar 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antihypertensive Agents/*therapeutic use
Biphenyl Compounds/*pharmacology
Hypertension/*drug therapy
Metabolic Syndrome/*drug therapy
Tetrazoles/*pharmacology
Trichlormethiazide/*pharmacology
Animals ; Antihypertensive Agents/administration & dosage ; Antioxidants/pharmacology ; Biphenyl Compounds/administration & dosage ; Blood Pressure/drug effects ; Heart Rate/drug effects ; Hypertension/complications ; Irbesartan ; Metabolic Syndrome/metabolism ; Rats, Inbred SHR ; Rats, Inbred WKY ; Tetrazoles/administration & dosage ; Trichlormethiazide/administration & dosage
Czasopismo naukowe
Tytuł:
Rationale and design of a multicenter randomized study comparing the efficacy and safety of esaxerenone versus trichlormethiazide in patients with uncontrolled essential hypertension: EXCITE‐HT study
Autorzy:
Kazuomi Kario
Mitsuru Ohishi
Tomohiro Katsuya
Takashi Taguchi
Ayumi Tanabe
Kotaro Sugimoto
Tatsuo Shimosawa
Pokaż więcej
Temat:
esaxerenone
hypertension
mineralocorticoid receptor blockers
randomized comparative study
trichlormethiazide
Diseases of the circulatory (Cardiovascular) system
RC666-701
Źródło:
The Journal of Clinical Hypertension, Vol 25, Iss 9, Pp 861-867 (2023)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176
Dostęp URL:
https://doaj.org/article/4f1daafbd74d4cb68c4d360d55611a43  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4.
Autorzy:
Sakoh T; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Sekine A; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Mori T; Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Mizuno H; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Kawada M; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Hiramatsu R; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Hasegawa E; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Hayami N; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Yamanouchi M; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Suwabe T; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Sawa N; Nephrology Center, Toranomon Hospital, Tokyo, Japan.
Ubara Y; Nephrology Center, Toranomon Hospital, Tokyo, Japan.; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan.
Fujimaru T; Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Sohara E; Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Shinichi U; Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Hoshino J; Nephrology Center, Toranomon Hospital, Tokyo, Japan.; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan.
Takaichi K; Nephrology Center, Toranomon Hospital, Tokyo, Japan.; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan.
Pokaż więcej
Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2019 Jun; Vol. 7 (6), pp. e705. Date of Electronic Publication: 2019 May 01.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Mutation, Missense*
Protein Serine-Threonine Kinases/*genetics
Pseudohypoaldosteronism/*genetics
Adult ; Amino Acid Motifs ; Antihypertensive Agents/therapeutic use ; Diuretics/therapeutic use ; Female ; Humans ; Pedigree ; Phenotype ; Protein Serine-Threonine Kinases/chemistry ; Pseudohypoaldosteronism/pathology ; Pseudohypoaldosteronism/therapy ; Trichlormethiazide/therapeutic use
Czasopismo naukowe
Tytuł:
Comparison of effects of low dose of spironolactone and a thiazide diuretic in patients with hypertension treated with an angiotensin-converting enzyme inhibitor or an angiotensin type 1 receptor blocker.
Autorzy:
Yutaka M; Miyashita Naika Clinic, 1-6-7 Gofuku-cho, Shizuoka, Japan. miyashita_ />Mifune M
Kubota E
Itoh H
Saito I
Pokaż więcej
Źródło:
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2009 Nov; Vol. 31 (8), pp. 648-56.
Typ publikacji:
Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms:
Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
Diuretics/*therapeutic use
Hypertension/*drug therapy
Spironolactone/*therapeutic use
Trichlormethiazide/*therapeutic use
Aged ; Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin-Converting Enzyme Inhibitors/administration & dosage ; Blood Pressure/drug effects ; Diuretics/administration & dosage ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Humans ; Hypertension/physiopathology ; Middle Aged ; Outpatients ; Prospective Studies ; Spironolactone/administration & dosage ; Treatment Outcome ; Trichlormethiazide/administration & dosage
Czasopismo naukowe
Tytuł:
New oral dosage form for elderly patients. III. Stability of trichlormethiazide in silk fibroin gel and various sugar solutions.
Autorzy:
Hanawa T; Pharmaceutical Department, Yamanashi Medical University, Japan. />Maeda R
Muramatsu E
Suzuki M
Sugihara M
Nakajima S
Pokaż więcej
Źródło:
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2000 Oct; Vol. 26 (10), pp. 1091-7.
Typ publikacji:
Journal Article
MeSH Terms:
Sodium Chloride Symporter Inhibitors/*pharmacokinetics
Trichlormethiazide/*pharmacokinetics
Administration, Oral ; Aged ; Chemical Phenomena ; Chemistry, Pharmaceutical ; Chemistry, Physical ; Diuretics ; Fibroins/chemistry ; Gels/chemistry ; Humans ; Hydrolysis ; Sodium Chloride Symporter Inhibitors/administration & dosage ; Trichlormethiazide/administration & dosage
Czasopismo naukowe
Tytuł:
Crystal structure from X-ray powder diffraction data, DFT-D calculation, Hirshfeld surface analysis, and energy frameworks of (RS)-trichlormethiazide
Autorzy:
Robert A. Toro
Analio Dugarte-Dugarte
Jacco van de Streek
José Antonio Henao
José Miguel Delgado
Graciela Díaz de Delgado
Pokaż więcej
Temat:
trichlormethiazide
structure determination
powder diffraction
dft-d calculations
hirshfeld surface analysis
energy frameworks
Crystallography
QD901-999
Źródło:
Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 2, Pp 140-148 (2022)
Opis pliku:
electronic resource
Relacje:
http://scripts.iucr.org/cgi-bin/paper?S2056989021013633; https://doaj.org/toc/2056-9890
Dostęp URL:
https://doaj.org/article/8bd1e1f04a0941df87ddc3db923f636b  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Duloxetine-induced hyponatremia in an elderly patient treated with thiazide diuretics.
Autorzy:
Mori M; Department of Pharmacy, Kuwana West Medical Center, Kuwana, Japan.
Koide T; Department of Pharmacy, Kuwana West Medical Center, Kuwana, Japan.
Imanishi Y; Department of Pharmacy, Kuwana West Medical Center, Kuwana, Japan.
Matsui Y; Department of Orthopaedic Surgery, Kuwana West Medical Center, Kuwana, Japan.
Matsuda T; Department of Orthopaedic Surgery, Kuwana West Medical Center, Kuwana, Japan.
Pokaż więcej
Źródło:
Indian journal of pharmacology [Indian J Pharmacol] 2014 Nov-Dec; Vol. 46 (6), pp. 657-9.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Antidepressive Agents/*adverse effects
Hyponatremia/*chemically induced
Sodium Chloride Symporter Inhibitors/*therapeutic use
Thiophenes/*adverse effects
Trichlormethiazide/*therapeutic use
Aged, 80 and over ; Drug Interactions ; Duloxetine Hydrochloride ; Female ; Humans
Czasopismo naukowe
Tytuł:
CUL3 gene analysis enables early intervention for pediatric pseudohypoaldosteronism type II in infancy.
Autorzy:
Osawa M; Department of Pediatrics, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Ogura Y
Isobe K
Uchida S
Nonoyama S
Kawaguchi H
Pokaż więcej
Źródło:
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2013 Sep; Vol. 28 (9), pp. 1881-4. Date of Electronic Publication: 2013 May 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cullin Proteins/*genetics
Pseudohypoaldosteronism/*genetics
Acid-Base Imbalance/blood ; Acid-Base Imbalance/genetics ; Acidosis/etiology ; Acidosis/therapy ; Bicarbonates/blood ; Blood Pressure/physiology ; Chlorides/blood ; Diuretics/therapeutic use ; Exons/genetics ; Genetic Testing ; Humans ; Infant ; Introns/genetics ; Male ; Potassium/blood ; Pseudohypoaldosteronism/diagnosis ; Pseudohypoaldosteronism/therapy ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Trichlormethiazide/therapeutic use
Czasopismo naukowe
Tytuł:
Salt-losing nephrogenic diabetes insipidus caused by fetal exposure to angiotensin receptor blocker.
Autorzy:
Miura K; Department of Pediatrics, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
Sekine T
Iida A
Takahashi K
Igarashi T
Pokaż więcej
Źródło:
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2009 Jun; Vol. 24 (6), pp. 1235-8. Date of Electronic Publication: 2009 Jan 20.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Prenatal Exposure Delayed Effects*
Angiotensin II Type 1 Receptor Blockers/*adverse effects
Diabetes Insipidus, Nephrogenic/*chemically induced
Diabetes Insipidus, Nephrogenic/*physiopathology
Arginine Vasopressin/metabolism ; Aspartic Acid/therapeutic use ; Child ; Child, Preschool ; Cyclic AMP/urine ; Female ; Glomerular Filtration Rate/drug effects ; Humans ; Kidney Function Tests ; Male ; Peritoneal Dialysis/methods ; Pregnancy ; Renal Insufficiency/therapy ; Sodium Chloride Symporter Inhibitors/therapeutic use ; Treatment Outcome ; Trichlormethiazide/therapeutic use
Czasopismo naukowe
Tytuł:
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.
Autorzy:
Menuz K; Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA.
Stroud RM
Nicoll RA
Hays FA
Pokaż więcej
Źródło:
Science (New York, N.Y.) [Science] 2007 Nov 02; Vol. 318 (5851), pp. 815-7.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Partial Agonism*
6-Cyano-7-nitroquinoxaline-2,3-dione/*pharmacology
Protein Subunits/*physiology
Receptors, AMPA/*agonists
Receptors, AMPA/*antagonists & inhibitors
6-Cyano-7-nitroquinoxaline-2,3-dione/chemistry ; Animals ; Benzodiazepines/pharmacology ; Binding, Competitive ; Cell Line ; Cerebellum/cytology ; Crystallography, X-Ray ; Hippocampus/cytology ; Humans ; In Vitro Techniques ; Interneurons/drug effects ; Mice ; Models, Molecular ; Patch-Clamp Techniques ; Protein Conformation ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Quinoxalines/pharmacology ; Structure-Activity Relationship ; Synaptic Transmission/drug effects ; Trichlormethiazide/pharmacology
Czasopismo naukowe
Tytuł:
Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients
Autorzy:
Miki Hosaka
Ryusuke Inoue
Michihiro Satoh
Daisuke Watabe
Tomohiro Hanazawa
Takayoshi Ohkubo
Kei Asayama
Taku Obara
Yutaka Imai
Pokaż więcej
Temat:
home blood pressure
microalbuminuria
irbesartan
amlodipine
efonidipine
trichlormethiazide
Diseases of the circulatory (Cardiovascular) system
RC666-701
Źródło:
Clinical and Experimental Hypertension, Vol 40, Iss 5, Pp 468-475 (2018)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006
Dostęp URL:
https://doaj.org/article/31126cc223644886b118ab88d63aaf81  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Effect of Water Mobility on Drug Hydrolysis Rates in Gelatin Gels
Autorzy:
Yoshioka, Sumie
Aso, Yukio
Terao, Tadao
Pokaż więcej
Źródło:
Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. May 1992 9(5):607-612
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies