Temat: "Triterpenes" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Synthesis, biological evaluation, molecular docking studies and In-silico ADMET evaluation of pyrazines of pentacyclic triterpenes.
Autorzy:: López-Huerta FA; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, Mexico.
Ramírez-Apan MT; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, Mexico.
Méndez-Cuesta CA; Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, Calzada del Hueso 1100, 04960 Ciudad de México, Mexico.
Nieto-Camacho A; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, Mexico.
Hernández-Ortega S; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, Mexico.
Almeida-Aguirre EKP; Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología, Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Chapultepec, 11000 Ciudad de México, Mexico; Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, Mexico.
Cerbón MA; Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología, Isidro Espinosa de los Reyes, Montes Urales 800, Lomas de Chapultepec, 11000 Ciudad de México, Mexico; Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, Mexico.
Delgado G; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Ciudad de México, Mexico. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic chemistry [Bioorg Chem] 2022 Aug; Vol. 125, pp. 105924. Date of Electronic Publication: 2022 Jun 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents*/chemistry
Triterpenes*/chemistry
Triterpenes*/pharmacology
Animals ; Anti-Inflammatory Agents/pharmacology ; Cell Line, Tumor ; Male ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Pentacyclic Triterpenes/pharmacology ; Pyrazines ; Structure-Activity Relationship

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Skocz do pozycji: 2.

Tytuł:: The multifaceted mechanisms of pristimerin in the treatment of tumors state-of-the-art.
Autorzy:: Wang Y; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China; Shandong Co-Innovation Center of Classic TCM Fomula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China.
Feng W; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China.
Wang X; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China; Shandong Co-Innovation Center of Classic TCM Fomula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China.
Li X; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China.
Mou Y; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China; Shandong Co-Innovation Center of Classic TCM Fomula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China.
Wang X; College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China.
Zhang Y; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China; Shandong Co-Innovation Center of Classic TCM Fomula, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China. Electronic address: .; Pokaż więcej
Źródło:: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Oct; Vol. 154, pp. 113575. Date of Electronic Publication: 2022 Aug 18.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinoma, Squamous Cell*
Mouth Neoplasms*
Triterpenes*/pharmacology
Triterpenes*/therapeutic use
Humans ; Male ; Pentacyclic Triterpenes ; Tumor Microenvironment

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Skocz do pozycji: 3.

Tytuł:: Novel Triterpenic Acid-Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents.
Autorzy:: Mioc M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Mioc A; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Department of Anatomy, Physiology, Pathophysiology, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Prodea A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Milan A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Balan-Porcarasu M; Institute of Macromolecular Chemistry 'Petru Poni', 700487 Iasi, Romania.
Racoviceanu R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Ghiulai R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Iovanescu G; Department of Otolaryngology, Faculty of Medicine, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Macasoi I; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Department of Toxicology, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Draghici G; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Department of Toxicology, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Dehelean C; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Department of Toxicology, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.
Soica C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Research Centre for Pharmaco-Toxicological Evaluation, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Sq., No. 2, 300041 Timisoara, Romania.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 01; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 01.
Typ publikacji:: Journal Article
MeSH Terms:: Oleanolic Acid*/chemistry
Oleanolic Acid*/pharmacology
Triterpenes*/chemistry
Triterpenes*/pharmacology
Apoptosis ; Cell Line, Tumor ; Esters/pharmacology ; Humans ; Molecular Docking Simulation ; Pentacyclic Triterpenes/pharmacology ; Proto-Oncogene Proteins c-bcl-2 ; Triazoles/pharmacology

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Skocz do pozycji: 4.

Tytuł:: Pentacyclic triterpenes from the leaves extract of Sandoricum koetjape.
Autorzy:: Saptanti K; Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia.
Heliawati L; Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Pakuan, Bogor, Indonesia.
Hermawati E; Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia.
Syah YM; Organic Chemistry Division, Bandung Institute of Technology, Jalan Ganesha 10, Bandung, 40132, Indonesia. .; Pokaż więcej
Źródło:: Journal of natural medicines [J Nat Med] 2022 Sep; Vol. 76 (4), pp. 842-848. Date of Electronic Publication: 2022 Apr 30.
Typ publikacji:: Journal Article
MeSH Terms:: Meliaceae*/chemistry
Triterpenes*/chemistry
Molecular Structure ; Pentacyclic Triterpenes/analysis ; Plant Extracts/analysis ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; beta-Lactamases/analysis

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Skocz do pozycji: 5.

Tytuł:: Celastrol inhibits LL37-induced rosacea by inhibiting Ca /CaMKII-mTOR-NF-κB activation.
Autorzy:: Zeng Q; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Yang J; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Yan G; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Zhang L; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Wang P; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Zhang H; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Chen Q; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Cao Y; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Liu X; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: .
Wang X; Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: wangxiuli_.; Pokaż więcej
Źródło:: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Sep; Vol. 153, pp. 113292. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:: Journal Article
MeSH Terms:: Rosacea*/chemically induced
Rosacea*/drug therapy
Triterpenes*/pharmacology
Triterpenes*/therapeutic use
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Humans ; Inflammation/drug therapy ; Mice ; NF-kappa B/metabolism ; Neovascularization, Pathologic/drug therapy ; Pentacyclic Triterpenes/therapeutic use ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 6.

Tytuł:: Research on the synthesis of nanoparticles of betulinic acid and their targeting antitumor activity.
Autorzy:: Chen X; College of Chemistry, Chemical Engineering and Resources Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.
Lu S; College of Chemistry, Chemical Engineering and Resources Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.
Gong F; College of Chemistry, Chemical Engineering and Resources Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.
Sui X; College of Pharmacy, Qiqihar Medical University, Qiqihar, China.
Liu T; College of Pharmacy, Qiqihar Medical University, Qiqihar, China.
Wang T; College of Chemistry, Chemical Engineering and Resources Utilization, Northeast Forestry University, Harbin, Heilongjiang, China.; Pokaż więcej
Źródło:: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2022 Aug; Vol. 110 (8), pp. 1789-1795. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Nanoparticles*
Triterpenes*/pharmacology
Triterpenes*/therapeutic use
Cell Line, Tumor ; Liposomes ; Pentacyclic Triterpenes/pharmacology

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Skocz do pozycji: 7.

Tytuł:: Celastrol Attenuates Psoriasiform Inflammation by Targeting the IRF1/GSTM3 Axis.
Autorzy:: Kuai L; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Ru Y; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Zhu QG; Department of Pharmacy, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
Yin SY; Center for Translational Medicine, Huaihe Hospital of Henan University, Kaifeng, China.
Li YY; Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhou M; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Luo Y; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Luo Y; Department of Traditional Chinese Medicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
Song JK; Department of Traditional Chinese Medicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
Fei XY; Department of Traditional Chinese Medicine, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
Jiang JS; Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.
Zhu CC; Department of Pharmacy, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
Li B; Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China; Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: .; Pokaż więcej
Źródło:: The Journal of investigative dermatology [J Invest Dermatol] 2022 Aug; Vol. 142 (8), pp. 2281-2285.e11. Date of Electronic Publication: 2022 Feb 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Psoriasis*/drug therapy
Triterpenes*/pharmacology
Triterpenes*/therapeutic use
Glutathione Transferase ; Humans ; Inflammation/drug therapy ; Interferon Regulatory Factor-1 ; Pentacyclic Triterpenes

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Skocz do pozycji: 8.

Tytuł:: Identification of a cytochrome P450 from Tripterygium hypoglaucum (Levl.) Hutch that catalyzes polpunonic acid formation in celastrol biosynthesis.
Autorzy:: Chen XC; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Lu Y; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Liu Y; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Zhou JW; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Zhang YF; Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Gao HY; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Li D; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Gao W; School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China; Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Electronic address: .; Pokaż więcej
Źródło:: Chinese journal of natural medicines [Chin J Nat Med] 2022 Sep; Vol. 20 (9), pp. 691-700.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Obesity Agents*
Triterpenes*/metabolism
Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Pentacyclic Triterpenes ; Squalene/analogs & derivatives ; Tripterygium/metabolism

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Skocz do pozycji: 9.

Tytuł:: Covalent Inhibition of Pyruvate Kinase M2 Reprograms Metabolic and Inflammatory Pathways in Hepatic Macrophages against Non-alcoholic Fatty Liver Disease.
Autorzy:: Fan N; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Zhang X; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Zhao W; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Zhao J; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Luo D; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Sun Y; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Li D; College of Chemistry and Pharmacy, Northwest A&F University, Shaanxi, China.
Zhao C; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Wang Y; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Zhang H; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Rong J; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; The University of Hong Kong Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, China.; Pokaż więcej
Źródło:: International journal of biological sciences [Int J Biol Sci] 2022 Aug 15; Vol. 18 (14), pp. 5260-5275. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Non-alcoholic Fatty Liver Disease*/drug therapy
Non-alcoholic Fatty Liver Disease*/metabolism
Triterpenes*/pharmacology
Animals ; Anti-Inflammatory Agents/therapeutic use ; Cholesterol/metabolism ; Glucose Transporter Type 1/metabolism ; Lipids ; Macrophages/metabolism ; Mice ; Pentacyclic Triterpenes ; Proto-Oncogene Proteins c-akt/metabolism ; Pyruvate Kinase/metabolism ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 10.

Tytuł:: Anti-adipogenic β-sitosterol and lupeol from Moringa oleifera suppress adipocyte differentiation through regulation of cell cycle progression.
Autorzy:: Vasanth K; Division of Molecular Biology, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur, India.
Minakshi GC; Division of Molecular Biology, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur, India.
Velu K; Centre for Ocean Research, Sathyabama Institute of Science and Technology, Chennai, India.
Priya T; Division of Molecular Biology, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur, India.
Kumar RM; Division of Phytochemistry, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur, India.
Kaliappan I; Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, India.
Dubey GP; National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.; Pokaż więcej
Źródło:: Journal of food biochemistry [J Food Biochem] 2022 Aug; Vol. 46 (8), pp. e14170. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:: Journal Article
MeSH Terms:: Moringa oleifera*/chemistry
Triterpenes*/pharmacology
Adipocytes ; Adipogenesis ; Cell Cycle ; Glucose ; Pentacyclic Triterpenes ; Sitosterols/pharmacology

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Skocz do pozycji: 11.

Tytuł:: Edible oils from olive drupes as a source of bioactive pentacyclic triterpenes. Is there a prospect for a health claim authorization?
Autorzy:: Papadaki E; Laboratory of Food Chemistry and Technology, School of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address: .
Tsimidou MZ; Laboratory of Food Chemistry and Technology, School of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address: .; Pokaż więcej
Źródło:: Food chemistry [Food Chem] 2022 Jul 01; Vol. 381, pp. 132286. Date of Electronic Publication: 2022 Jan 31.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Olea*/chemistry
Triterpenes*/analysis
Gas Chromatography-Mass Spectrometry ; Olive Oil/chemistry ; Pentacyclic Triterpenes ; Plant Oils/chemistry

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Skocz do pozycji: 12.

Tytuł:: Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway.
Autorzy:: Fontana G; Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze ed. 17, 90128 Palermo, Italy.
Badalamenti N; Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze ed. 17, 90128 Palermo, Italy.
Bruno M; Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze ed. 17, 90128 Palermo, Italy.
Castiglione D; Dipartimento di Chimica, University of Turin, Via Pietro Giuria 7, 10125 Turin, Italy.
Notarbartolo M; Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze ed. 17, 90128 Palermo, Italy.
Poma P; Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze ed. 17, 90128 Palermo, Italy.
Spinella A; Centro Grandi Apparecchiature (CGA)-ATeN Center, University of Palermo, Via F. Marini 14, 90128 Palermo, Italy.
Tutone M; Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze ed. 17, 90128 Palermo, Italy.
Labbozzetta M; Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Viale delle Scienze ed. 17, 90128 Palermo, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 13; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 13.
Typ publikacji:: Journal Article
MeSH Terms:: Leukemia*/drug therapy
Neoplasms*
Oleanolic Acid*
Triterpenes*/chemistry
Triterpenes*/pharmacology
Cell Line ; Humans ; NF-kappa B/metabolism ; Pentacyclic Triterpenes

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Skocz do pozycji: 13.

Tytuł:: Synthesis and cytotoxicity of betulin and betulinic acid derived 30-oxo-amides.
Autorzy:: Kozubek M; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Hoenke S; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Schmidt T; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
Deigner HP; Furtwangen University, Institute of Precision Medicine, Medical and Life Science Faculty, Jakob-Kienzle-Str. 17, D-78054 Villigen, Schwenningen, Germany.
Al-Harrasi A; University of Nizwa, Chair of Oman's Medicinal Plants and Marine Natural Products, P.O. Box 33, PC 616, Birkat Al-Mauz, Nizwa, Oman.
Csuk R; Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.; Pokaż więcej
Źródło:: Steroids [Steroids] 2022 Jun; Vol. 182, pp. 109014. Date of Electronic Publication: 2022 Mar 18.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Triterpenes*/chemistry
Triterpenes*/pharmacology
Amides/chemistry ; Amides/pharmacology ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Pentacyclic Triterpenes ; Structure-Activity Relationship

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Skocz do pozycji: 14.

Tytuł:: Decoration of A-Ring of a Lupane-Type Triterpenoid with Different Oxygen and Nitrogen Heterocycles.
Autorzy:: Sousa JLC; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Albuquerque HMT; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Silvestre AJD; CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Silva AMS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Jul 31; Vol. 27 (15). Date of Electronic Publication: 2022 Jul 31.
Typ publikacji:: Journal Article
MeSH Terms:: Nitrogen*
Triterpenes*
Cyclization ; Oxygen ; Pentacyclic Triterpenes

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Skocz do pozycji: 15.

Tytuł:: Seco -Lupane Triterpene Derivatives Induce Ferroptosis through GPX4/ACSL4 Axis and Target Cyclin D1 to Block the Cell Cycle.
Autorzy:: Wang H; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Wu D; Department of Breast Surgery, First Hospital of Jilin University, Changchun 130021, China.
Gao C; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Teng H; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Zhao Y; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Changchun 130118, China.; Key Laboratory of Animal Production and Product Quality and Security, Ministry of Education, Ministry of National Education, Changchun 130118, China.
He Z; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Changchun 130118, China.; Key Laboratory of Animal Production and Product Quality and Security, Ministry of Education, Ministry of National Education, Changchun 130118, China.
Chen W; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Changchun 130118, China.; Key Laboratory of Animal Production and Product Quality and Security, Ministry of Education, Ministry of National Education, Changchun 130118, China.
Zong Y; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Changchun 130118, China.; Key Laboratory of Animal Production and Product Quality and Security, Ministry of Education, Ministry of National Education, Changchun 130118, China.
Du R; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.; Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer, Changchun 130118, China.; Key Laboratory of Animal Production and Product Quality and Security, Ministry of Education, Ministry of National Education, Changchun 130118, China.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2022 Jul 28; Vol. 65 (14), pp. 10014-10044. Date of Electronic Publication: 2022 Jul 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents*/pharmacology
Ferroptosis*
Triterpenes*/pharmacology
Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Cyclin D1/pharmacology ; Imidazoles/pharmacology ; Indoles/pharmacology ; Molecular Structure ; Pentacyclic Triterpenes/pharmacology ; Sulfonamides ; Thiophenes

Czasopismo naukowe

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Szczegóły

Skocz do pozycji: 16.

Tytuł:: Asiatic acid from centella asiatica exert anti-invasive ability in human renal cancer cells by modulation of ERK/p38MAPK-mediated MMP15 expression.
Autorzy:: Huang CF; Department of Critical Care Medicine, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
Hung TW; Division of Nephrology, Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
Tsai YL; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Yang JT; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Lin CL; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Institute of Biomedical Sciences, MacKay Medical College, New Taipei City, Taiwan. Electronic address: .
Hsieh YH; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: .; Pokaż więcej
Źródło:: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Jun; Vol. 100, pp. 154036. Date of Electronic Publication: 2022 Mar 14.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Renal Cell*/drug therapy
Centella*/chemistry
Kidney Neoplasms*/metabolism
Triterpenes*/pharmacology
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Humans ; Male ; Matrix Metalloproteinase 15 ; Mice ; Pentacyclic Triterpenes ; RNA, Small Interfering/pharmacology ; p38 Mitogen-Activated Protein Kinases

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Szczegóły

Skocz do pozycji: 17.

Tytuł:: Mitochondria-targeted polymer-celastrol conjugate with enhanced anticancer efficacy.
Autorzy:: Geng Y; Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311215, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Xiang J; Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311215, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Shao S; Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311215, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: .
Tang J; Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311215, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Shen Y; Zhejiang Key Laboratory of Smart BioMaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311215, China; Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: .; Pokaż więcej
Źródło:: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Feb; Vol. 342, pp. 122-133. Date of Electronic Publication: 2022 Jan 05.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Polymers*/metabolism
Triterpenes*/pharmacology
Triterpenes*/therapeutic use
Mitochondria ; Pentacyclic Triterpenes/metabolism

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 18.

Tytuł:: Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-κB/MAPK signalling pathways and activating the Nrf2 signalling pathway.
Autorzy:: Ou Z; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Zhu L; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Huang C; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Ma C; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Kong L; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Lin X; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Gao X; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Huang L; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Wen L; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Liang Z; Department of Hunan Agricultural Product Processing Institute, Changsha 410128, China.
Yuan Z; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.
Wu J; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China. Electronic address: .
Yi J; Hunan Engineering Research Center of Livestock and Poultry Health Care, Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China. Electronic address: .; Pokaż więcej
Źródło:: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Dec 01; Vol. 225, pp. 112746. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji:: Journal Article
MeSH Terms:: NF-E2-Related Factor 2*/genetics
NF-E2-Related Factor 2*/metabolism
Triterpenes*/metabolism
Triterpenes*/pharmacology
Animals ; Cyclophosphamide/toxicity ; Intestinal Mucosa/metabolism ; Mice ; Mitogens/metabolism ; NF-kappa B/metabolism ; Oxidative Stress ; Pentacyclic Triterpenes

Czasopismo naukowe

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Szczegóły

Skocz do pozycji: 19.

Tytuł:: Anti-Toxoplasma gondii effect of lupane-type triterpenes from the bark of black alder (Alnus glutinosa) and identification of a potential target by reverse docking.
Autorzy:: Darme P; Université de Reims Champagne Ardenne, ESCAPE EA 7510, 51097 Reims, France - Université de Reims Champagne Ardenne, CNRS, ICMR 7312, 51097 Reims, France.
Escotte-Binet S; Université de Reims Champagne Ardenne, ESCAPE EA 7510, 51097 Reims, France.
Cordonnier J; Université de Reims Champagne Ardenne, ESCAPE EA 7510, 51097 Reims, France - Université de Reims Champagne Ardenne, CNRS, ICMR 7312, 51097 Reims, France.
Remy S; Université de Reims Champagne Ardenne, ESCAPE EA 7510, 51097 Reims, France.
Hubert J; NatExplore SAS, 51140 Prouilly, France.
Sayagh C; Université de Reims Champagne Ardenne, CNRS, ICMR 7312, 51097 Reims, France.
Borie N; Université de Reims Champagne Ardenne, CNRS, ICMR 7312, 51097 Reims, France.
Villena I; Université de Reims Champagne Ardenne, ESCAPE EA 7510, 51097 Reims, France.
Voutquenne-Nazabadioko L; Université de Reims Champagne Ardenne, CNRS, ICMR 7312, 51097 Reims, France.
Dauchez M; Université de Reims Champagne Ardenne, MEDyC UMR 7369, 51093 Reims, France - Université de Reims Champagne Ardenne, P3 M, 51097 Reims, France.
Baud S; Université de Reims Champagne Ardenne, MEDyC UMR 7369, 51093 Reims, France - Université de Reims Champagne Ardenne, P3 M, 51097 Reims, France.
Renault JH; Université de Reims Champagne Ardenne, CNRS, ICMR 7312, 51097 Reims, France.
Aubert D; Université de Reims Champagne Ardenne, ESCAPE EA 7510, 51097 Reims, France.; Pokaż więcej
Transliterated Title:: Potentiel anti-Toxoplasma gondii de triterpènes de type lupane de l’écorce de l’aulne glutineux, Alnus glutinosa, et identification d’une cible potentielle par docking inverse.
Źródło:: Parasite (Paris, France) [Parasite] 2022; Vol. 29, pp. 7. Date of Electronic Publication: 2022 Feb 10.
Typ publikacji:: Journal Article
MeSH Terms:: Alnus*
Ilex*
Toxoplasma*
Triterpenes*
Humans ; Pentacyclic Triterpenes ; Plant Bark ; Pregnancy

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 20.

Tytuł:: Pristimerin induces apoptosis and tumor inhibition of oral squamous cell carcinoma through activating ROS-dependent ER stress/Noxa pathway.
Autorzy:: Zhao Q; Department of Stomatology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Laboratory of Inflammation and Molecular Pharmacology, School of Basic Medical Sciences & Biomedical Research Institute, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China; Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan 442000, China.
Cheng X; Laboratory of Inflammation and Molecular Pharmacology, School of Basic Medical Sciences & Biomedical Research Institute, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China.
Yu W; Department of Stomatology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China.
Bi Y; Laboratory of Inflammation and Molecular Pharmacology, School of Basic Medical Sciences & Biomedical Research Institute, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China.
Guo J; Laboratory of Inflammation and Molecular Pharmacology, School of Basic Medical Sciences & Biomedical Research Institute, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China.
Ma Q; Laboratory of Inflammation and Molecular Pharmacology, School of Basic Medical Sciences & Biomedical Research Institute, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China.
Gong Y; Laboratory of Inflammation and Molecular Pharmacology, School of Basic Medical Sciences & Biomedical Research Institute, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China; Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan 442000, China.
He L; Department of Stomatology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China. Electronic address: eye_.
Yu X; Department of Stomatology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, China; Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China; Laboratory of Inflammation and Molecular Pharmacology, School of Basic Medical Sciences & Biomedical Research Institute, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan 442000, China. Electronic address: .; Pokaż więcej
Źródło:: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Nov; Vol. 92, pp. 153723. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Squamous Cell*/drug therapy
Head and Neck Neoplasms*
Mouth Neoplasms*/drug therapy
Triterpenes*/pharmacology
Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Endoplasmic Reticulum Stress ; Humans ; Pentacyclic Triterpenes ; Reactive Oxygen Species ; Squamous Cell Carcinoma of Head and Neck

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