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Tytuł :
Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle.
Autorzy :
Li MX; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Mercier P; National High Field NMR Centre, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Hartman JJ; Cytokinetics, Inc., South San Francisco, California 94080, United States.
Sykes BD; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 3026-3034. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Imidazoles/*pharmacology
Muscle, Skeletal/*drug effects
Pyrazines/*pharmacology
Troponin C/*metabolism
Troponin I/*metabolism
Binding Sites/drug effects ; Crystallography, X-Ray ; Humans ; Imidazoles/chemistry ; Molecular Docking Simulation ; Muscle, Skeletal/physiology ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation/drug effects ; Pyrazines/chemistry ; Troponin C/chemistry ; Troponin I/chemistry
Czasopismo naukowe
Tytuł :
A Mechanism Underlying Sex-Associated Differences in Ankylosing Spondylitis: Troponin C2, Fast Skeletal Type (TNNC2) and Calcium Signaling Pathway.
Autorzy :
Yu C; Guangxi Medical University, Nanning, Guangxi, China (mainland).
Zhan X; Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).
Liu C; Spine and Osteopathy Ward, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).
Zhang Z; Guangxi Medical University, Nanning, Guangxi, China (mainland).
Jiang J; Guangxi Medical University, Nanning, Guangxi, China (mainland).
Xu G; Guangxi Medical University, Nanning, Guangxi, China (mainland).
Xue J; Guangxi Medical University, Nanning, Guangxi, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2020 Oct 14; Vol. 26, pp. e925179. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Signaling*
Databases, Factual*
Gene Expression Regulation*
Sex Characteristics*
Transcriptome*
Spondylitis, Ankylosing/*metabolism
Troponin C/*biosynthesis
Female ; Humans ; Male ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/pathology ; Troponin C/genetics
Czasopismo naukowe
Tytuł :
Eliminating the First Inactive State and Stabilizing the Active State of the Cardiac Regulatory System Alters Behavior in Solution and in Ordered Systems.
Autorzy :
Johnson D; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.
Landim-Vieira M; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States.
Solı S C; Department of Chemistry and Biochemistry, South Dakota State University, Brookings, South Dakota 57007, United States.
Zhu L; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.
Robinson JM; Department of Chemistry and Biochemistry, South Dakota State University, Brookings, South Dakota 57007, United States.
Pinto JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States.
Chalovich JM; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Sep 22; Vol. 59 (37), pp. 3487-3497. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Movement*
Actins/*metabolism
Calcium/*metabolism
Myocardium/*metabolism
Tropomyosin/*metabolism
Troponin C/*metabolism
Troponin T/*metabolism
Adenosine Triphosphatases/metabolism ; Animals ; Cattle ; Humans ; Myocardium/cytology ; Protein Binding ; Troponin C/chemistry ; Troponin C/genetics ; Troponin T/chemistry ; Troponin T/genetics
Czasopismo naukowe
Tytuł :
TNNC1 Reduced Gemcitabine Sensitivity of Nonsmall-Cell Lung Cancer by Increasing Autophagy.
Autorzy :
Ye X; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
Xie G; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
Liu Z; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
Tang J; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
Cui M; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
Wang C; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
Guo C; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
Tang J; Department of Cardiovascular Thoracic Surgery, The Central Hospital of Yongzhou, Yongzhou, Hunan, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2020 Sep 18; Vol. 26, pp. e922703. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Carcinoma, Non-Small-Cell Lung/*metabolism
Deoxycytidine/*analogs & derivatives
Lung Neoplasms/*metabolism
Neoplasm Proteins/*biosynthesis
Troponin C/*biosynthesis
A549 Cells ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Deoxycytidine/pharmacology ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Neoplasm Proteins/genetics ; Troponin C/genetics
Czasopismo naukowe
Tytuł :
Photostable and Proteolysis-Resistant Förster Resonance Energy Transfer-Based Calcium Biosensor.
Autorzy :
Nguyen D; Department of Biomedical Engineering, University of California, Irvine, California 92697-2730, United States.
Behrens DM; Department of Biomedical Engineering, University of California, Irvine, California 92697-2730, United States.
Sen S; Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, United States.
Najdahmadi A; Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612-1475, United States.
Pham JN; Department of Chemistry, University of California, Irvine, California 92697-2015, United States.
Speciale G; Department of Chemistry, University of California, Irvine, California 92697-2015, United States.
Lawrence MM; Department of Biomedical Engineering, University of California, Irvine, California 92697-2730, United States.
Majumdar S; Department of Chemistry, University of California, Irvine, California 92697-2015, United States.
Weiss GA; Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, United States.; Department of Chemistry, University of California, Irvine, California 92697-2015, United States.; Department of Pharmaceutical Sciences, University of California, Irvine, California 92697-4625, United States.
Botvinick EL; Department of Biomedical Engineering, University of California, Irvine, California 92697-2730, United States.; Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612-1475, United States.; Department of Surgery, University of California, Irvine, California 92697-2730, United States.
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Źródło :
Analytical chemistry [Anal Chem] 2020 Jun 02; Vol. 92 (11), pp. 7683-7689. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescence Resonance Energy Transfer*
Calcium/*analysis
Troponin C/*metabolism
Animals ; Batrachoidiformes/metabolism ; Calcium/metabolism ; Photochemical Processes ; Proteolysis ; Troponin C/chemistry
Czasopismo naukowe
Tytuł :
Molecular characterization of troponin C (TnC) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection.
Autorzy :
Zhao Y; Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang Agriculture and Forestry University, Hangzhou, 311300, China.
Zheng K; Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang Agriculture and Forestry University, Hangzhou, 311300, China.
Zhu F; Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang Agriculture and Forestry University, Hangzhou, 311300, China. Electronic address: .
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Źródło :
Fish & shellfish immunology [Fish Shellfish Immunol] 2020 Mar; Vol. 98, pp. 522-533. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article
MeSH Terms :
Brachyura/*microbiology
Troponin C/*metabolism
Vibrio alginolyticus/*physiology
White spot syndrome virus 1/*physiology
Amino Acid Sequence ; Animals ; Base Sequence ; Brachyura/metabolism ; Brachyura/virology ; Gene Expression Regulation/immunology ; Host-Pathogen Interactions ; RNA Interference ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Tissue Distribution ; Troponin C/genetics
Czasopismo naukowe
Tytuł :
Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy.
Autorzy :
Dieseldorff Jones KM; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Vied C; Translational Science Laboratory, College of Medicine, Florida State University, Tallahassee, FL, USA.
Valera IC; Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA.
Chase PB; Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Parvatiyar MS; Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA.
Pinto JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
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Źródło :
Physiological reports [Physiol Rep] 2020 Mar; Vol. 8 (6), pp. e14396.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Sex Characteristics*
Transcriptome*
Cardiomyopathy, Hypertrophic/*metabolism
Troponin C/*metabolism
Animals ; Disease Models, Animal ; Female ; Hemodynamics ; Male ; Mice, Transgenic ; Troponin C/genetics
Czasopismo naukowe
Tytuł :
Interpretation of elevated high-sensitivity cardiac troponin I in elite soccer players previously infected by severe acute respiratory syndrome coronavirus 2.
Autorzy :
Mascia G; Cardiovascular and Thoracic Department, IRCCS Ospedale Policlinico San Martino, Genova, Italia - Italian IRCCS Cardiovascular Network.
Pescetelli F; Università di Genova, Dipartimento di Medicina Interna e Specialità Mediche (DIMI), Genova, Italy.
Baldari A; U.C. Sampdoria, Torre B, Piazza Borgo Pila, 39/Piano 5, 16129 Genova, Italy.
Gatto P; Genoa Cricket and Soccer Club, Centro Sportivo PIO XII - G. Signorini, via Ronchi 67, Genova, Italy.
Seitun S; Department of Radiology and Interventional Radiology, IRCCS Ospedale Policlinico San Martino, Genova, Italia - Italian IRCCS Cardiovascular Network, Italy.
Sartori P; Cardiovascular and Thoracic Department, IRCCS Ospedale Policlinico San Martino, Genova, Italia - Italian IRCCS Cardiovascular Network.
Pieroni M; Cardiovascular Department, San Donato Hospital, Arezzo, Italy.
Calò L; Department of Cardiology, Policlinico Casillino Hospital, Rome, Italy.
Della Bona R; Cardiovascular and Thoracic Department, IRCCS Ospedale Policlinico San Martino, Genova, Italia - Italian IRCCS Cardiovascular Network.
Porto I; Cardiovascular and Thoracic Department, IRCCS Ospedale Policlinico San Martino, Genova, Italia - Italian IRCCS Cardiovascular Network; Università di Genova, Dipartimento di Medicina Interna e Specialità Mediche (DIMI), Genova, Italy. Electronic address: .
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Źródło :
International journal of cardiology [Int J Cardiol] 2021 Mar 01; Vol. 326, pp. 248-251. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Athletes*
COVID-19/*blood
SARS-CoV-2/*isolation & purification
Soccer/*physiology
Troponin C/*blood
Biomarkers/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cohort Studies ; Humans ; Italy/epidemiology ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Puerarin alleviates coronary heart disease via suppressing inflammation in a rat model.
Autorzy :
Zhao L; Department of Cardiology, The Second Affiliated Hospital of Soochow University, Gusu District, Suzhou, Jiangsu Province 215004, China. Electronic address: .
Wang L; Department of Cardiology, The Second Affiliated Hospital of Soochow University, Gusu District, Suzhou, Jiangsu Province 215004, China.
Zhang D; Department of Cardiology, Nanjing First Hospital, Qinhuai District, Nanjing, Jiangsu Province 210001, China.
Chen Y; Department of Cardiology, The Second Affiliated Hospital of Soochow University, Gusu District, Suzhou, Jiangsu Province 215004, China.
Jin F; Department of Cardiology, The Second Affiliated Hospital of Soochow University, Gusu District, Suzhou, Jiangsu Province 215004, China.
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Źródło :
Gene [Gene] 2021 Mar 01; Vol. 771, pp. 145354. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*administration & dosage
Coronary Disease/*drug therapy
Gene Regulatory Networks/*drug effects
Isoflavones/*administration & dosage
Animals ; Anti-Inflammatory Agents/pharmacology ; Coronary Disease/genetics ; Creatine Kinase/blood ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Isoflavones/pharmacology ; L-Lactate Dehydrogenase/blood ; Male ; Rats ; Troponin C/blood
Czasopismo naukowe
Tytuł :
Optimal cut-off value of elevated cardiac troponin concentrations for myocardial injury predicts clinical outcomes in adult patients with COVID-19: a dose-response analysis protocol for systematic review.
Autorzy :
Zhou C; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China .
Pei H; Department of Cardiology, First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China.
Gao Y; Department of Echocardiography, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zhang Y; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cao L; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Fang Z; Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Song J; Department of Cardiac Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China .
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Źródło :
BMJ open [BMJ Open] 2021 Jan 08; Vol. 11 (1), pp. e046575. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Research Design*
COVID-19/*blood
Cardiomyopathies/*blood
Cardiomyopathies/*etiology
Systematic Reviews as Topic/*methods
Troponin C/*blood
COVID-19/mortality ; Cardiomyopathies/mortality ; Hospital Mortality ; Humans ; Predictive Value of Tests ; Prognosis
Czasopismo naukowe
Tytuł :
The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation.
Autorzy :
Johnston JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.
Landim-Vieira M; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.
Marques MA; Programa de Biologia Estrutural, Instituto de Bioquímica Médica, Instituto Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
de Oliveira GAP; Programa de Biologia Estrutural, Instituto de Bioquímica Médica, Instituto Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Gonzalez-Martinez D; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.
Moraes AH; Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
He H; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306.; Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306.
Iqbal A; Programa de Biologia Estrutural, Instituto de Bioquímica Médica, Instituto Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Wilnai Y; Department of Pediatrics, Dana-Dwek ChildrenγÇÖs Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 6423906.
Birk E; Department of Cardiology, Schneider ChildrenγÇÖs Medical Center, Tel Aviv University, Petah Tikva, Israel 4920235.
Zucker N; Department of Cardiology, Schneider ChildrenγÇÖs Medical Center, Tel Aviv University, Petah Tikva, Israel 4920235.
Silva JL; Programa de Biologia Estrutural, Instituto de Bioquímica Médica, Instituto Nacional de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Chase PB; Department of Biological Science, Florida State University, Tallahassee, Florida 32306.
Pinto JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306 .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Dec 27; Vol. 294 (52), pp. 20054-20069. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Troponin C/*metabolism
Troponin T/*metabolism
Binding Sites ; Calcium/metabolism ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Female ; Humans ; Male ; Mutagenesis, Site-Directed ; Myocardial Contraction ; Myocardium/metabolism ; Myofibrils/physiology ; Nuclear Magnetic Resonance, Biomolecular ; Pedigree ; Protein Binding ; Protein Domains ; Protein Structure, Secondary ; Troponin C/chemistry ; Troponin T/chemistry ; Troponin T/genetics
Czasopismo naukowe
Tytuł :
A Dynamic Situation with Uncertainty: Multiscale Modeling of Cardiac Thin-Filament Ca Regulation.
Autorzy :
Chase PB; Department of Biological Science, Florida State University, Tallahassee, Florida. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2019 Dec 17; Vol. 117 (12), pp. 2241-2243. Date of Electronic Publication: 2019 Sep 28.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Actin Cytoskeleton*
Troponin C*
Uncertainty
Czasopismo naukowe
Tytuł :
Conformation switching of single native proteins revealed by nanomechanical probing without a pulling force.
Autorzy :
Gutiérrez-Mejía FA; Department of Applied Physics, Eindhoven University of Technology (TU/e), Eindhoven, The Netherlands. (ICMS), TU/e, Eindhoven, The Netherlands.
Moerland CP; Department of Applied Physics, Eindhoven University of Technology (TU/e), Eindhoven, The Netherlands. (ICMS), TU/e, Eindhoven, The Netherlands.
van IJzendoorn LJ; Department of Applied Physics, Eindhoven University of Technology (TU/e), Eindhoven, The Netherlands. (ICMS), TU/e, Eindhoven, The Netherlands.
Prins MWJ; Department of Applied Physics, Eindhoven University of Technology (TU/e), Eindhoven, The Netherlands. (ICMS), TU/e, Eindhoven, The Netherlands and Department of Biomedical Engineering, TU/e, Eindhoven, The Netherlands.
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Źródło :
Nanoscale [Nanoscale] 2019 Nov 14; Vol. 11 (42), pp. 19933-19942. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*chemistry
Myocardium/*chemistry
Troponin C/*chemistry
Biomarkers/metabolism ; Calcium/metabolism ; Humans ; Myocardial Infarction/metabolism ; Myocardium/metabolism ; Protein Domains ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
The Positively Charged C-Terminal Region of Human Skeletal Troponin T Retards Activation and Decreases Calcium Sensitivity.
Autorzy :
Lopez Davila AJ; Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.
Zhu L; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, United States.
Fritz L; Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.
Kraft T; Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Street 1, 103-Block 1-Ebene 03-1010, Hannover 30625, Germany.
Chalovich JM; Department of Biochemistry & Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, United States.
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Źródło :
Biochemistry [Biochemistry] 2020 Nov 03; Vol. 59 (43), pp. 4189-4201. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*pharmacology
Troponin T/*metabolism
Humans ; Kinetics ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Tropomyosin/chemistry ; Tropomyosin/metabolism ; Troponin C/chemistry ; Troponin C/metabolism ; Troponin I/chemistry ; Troponin I/metabolism ; Troponin T/chemistry
Czasopismo naukowe
Tytuł :
Bioinformatics-based discovery of PYGM and TNNC2 as potential biomarkers of head and neck squamous cell carcinoma.
Autorzy :
Jin Y; Department of General Dentistry, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, 200000, P.R. China.
Yang Y; Department of General Dentistry, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China .; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, 200000, P.R. China.
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Źródło :
Bioscience reports [Biosci Rep] 2019 Jul 29; Vol. 39 (7). Date of Electronic Publication: 2019 Jul 29 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Computational Biology*
Biomarkers, Tumor/*genetics
Carcinoma, Squamous Cell/*genetics
Glycogen Phosphorylase/*genetics
Head and Neck Neoplasms/*genetics
Neoplasm Proteins/*genetics
Troponin C/*genetics
Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/metabolism ; Databases, Nucleic Acid ; Glycogen Phosphorylase/metabolism ; Head and Neck Neoplasms/metabolism ; Humans ; Neoplasm Proteins/metabolism ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts.
Autorzy :
Powers JD; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA.; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.
Kooiker KB; Division of Cardiology, School of Medicine, University of Washington, Seattle, Washington, USA.
Mason AB; Department of Chemistry and Biochemistry, College of Science, and.
Teitgen AE; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.
Flint GV; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA.
Tardiff JC; Department of Biomedical Engineering, College of Engineering, University of Arizona, Tucson, Arizona, USA.
Schwartz SD; Department of Chemistry and Biochemistry, College of Science, and.
McCulloch AD; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.; Department of Medicine, University of California San Diego, La Jolla, California, USA.
Regnier M; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA.
Davis J; Department of Bioengineering, College of Engineering and School of Medicine, University of Washington, Seattle, Washington, USA.; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, Washington, USA.
Moussavi-Harami F; Division of Cardiology, School of Medicine, University of Washington, Seattle, Washington, USA.
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Źródło :
JCI insight [JCI Insight] 2020 Oct 15; Vol. 5 (20). Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling/*genetics
Cardiomyopathy, Dilated/*genetics
Heart/*growth & development
Troponin C/*genetics
Amino Acid Substitution/genetics ; Animals ; Calcium/metabolism ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Heart/physiopathology ; Humans ; Mice ; Mice, Transgenic ; Mutation/genetics ; Myocardial Contraction/genetics ; Myocardium/metabolism ; Myocardium/pathology ; Myofibrils/genetics ; Myofibrils/pathology ; Sarcomeres/genetics ; Sarcomeres/pathology
Czasopismo naukowe
Tytuł :
Mechanism of Cardiac Troponin C Calcium Sensitivity Modulation by Small Molecules Illuminated by Umbrella Sampling Simulations.
Autorzy :
Bowman JD; Department of Chemistry and Biochemistry , Ohio State University , 2114 Newman & Wolfrom Laboratory, 100 West 18th Avenue , Columbus , Ohio 43210 , United States.
Coldren WH; Department of Chemistry and Biochemistry , Ohio State University , 2114 Newman & Wolfrom Laboratory, 100 West 18th Avenue , Columbus , Ohio 43210 , United States.
Lindert S; Department of Chemistry and Biochemistry , Ohio State University , 2114 Newman & Wolfrom Laboratory, 100 West 18th Avenue , Columbus , Ohio 43210 , United States.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2019 Jun 24; Vol. 59 (6), pp. 2964-2972. Date of Electronic Publication: 2019 May 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Molecular Dynamics Simulation*
Calcium/*metabolism
Myocardium/*metabolism
Small Molecule Libraries/*pharmacology
Troponin C/*metabolism
Hydrophobic and Hydrophilic Interactions ; Protein Domains ; Thermodynamics ; Troponin C/chemistry ; Troponin I/metabolism
Czasopismo naukowe
Tytuł :
Characterization of the L29Q Hypertrophic Cardiomyopathy Mutation in Cardiac Troponin C by Paramagnetic Relaxation Enhancement Nuclear Magnetic Resonance.
Autorzy :
Potluri PR; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
Cordina NM; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
Kachooei E; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
Brown LJ; Department of Molecular Sciences , Macquarie University , Sydney , NSW 2109 , Australia.
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Źródło :
Biochemistry [Biochemistry] 2019 Feb 19; Vol. 58 (7), pp. 908-917. Date of Electronic Publication: 2019 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Cardiomyopathy, Hypertrophic/*genetics
Leucine/*genetics
Troponin C/*chemistry
Troponin C/*genetics
Animals ; Calcium/metabolism ; Cysteine/chemistry ; Cysteine/genetics ; Electron Spin Resonance Spectroscopy ; Humans ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Protein Conformation ; Protein Domains ; Rats ; Spin Labels ; Troponin C/metabolism
Czasopismo naukowe
Tytuł :
Structural and functional impact of troponin C-mediated Ca sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle.
Autorzy :
Gonzalez-Martinez D; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Johnston JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Landim-Vieira M; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Ma W; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL, USA.
Antipova O; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL, USA; X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory, Lemont, IL, USA.
Awan O; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA.
Irving TC; Department of Biological Sciences, Illinois Institute of Technology, Chicago, IL, USA.
Bryant Chase P; Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Pinto JR; Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA. Electronic address: .
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2018 Oct; Vol. 123, pp. 26-37. Date of Electronic Publication: 2018 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Myocardial Contraction*
Calcium/*metabolism
Myocardium/*metabolism
Myofibrils/*metabolism
Troponin C/*metabolism
Algorithms ; Animals ; Calcium Signaling ; Cardiomyopathy, Hypertrophic/genetics ; Cardiomyopathy, Hypertrophic/metabolism ; Cardiomyopathy, Hypertrophic/pathology ; Cardiomyopathy, Hypertrophic/physiopathology ; Disease Models, Animal ; Female ; Humans ; Isometric Contraction ; Kinetics ; Male ; Mice ; Models, Molecular ; Models, Theoretical ; Mutation ; Myocardium/chemistry ; Myofibrils/chemistry ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Structure-Activity Relationship ; Troponin C/chemistry ; Troponin C/genetics
Czasopismo naukowe
Tytuł :
The missing links within troponin.
Autorzy :
Marques MA; Programa de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Parvatiyar MS; Department of Nutrition, Food and Exercise Sciences, Florida State University, 107 Chieftan Way, Tallahassee, FL, 32306-1493, USA.
Yang W; Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Kasha Laboratory Building, 91 Chieftan Way, Tallahassee, FL, 32306-4380, USA.
de Oliveira GAP; Programa de Biologia Estrutural, Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908-0733, USA. Electronic address: .
Pinto JR; Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL, 32306-4300, USA. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2019 Mar 15; Vol. 663, pp. 95-100. Date of Electronic Publication: 2018 Dec 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Troponin C/*metabolism
Troponin I/*metabolism
Allosteric Regulation ; Amino Acid Sequence ; Animals ; Humans ; Protein Binding ; Structure-Activity Relationship ; Troponin C/chemistry ; Troponin I/chemistry
Czasopismo naukowe

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