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Tytuł:
A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation.
Autorzy:
Mao W; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA.
Miller CM; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Ge Y; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Amper MAS; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Cappuccio A; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
George MC; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Goforth CW; Naval Medical Research Center, MD, Silver Spring, USA.
Guevara K; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Marjanovic N; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Nudelman G; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Pincas H; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Ramos I; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Sealfon RSG; Center for Computational Biology, Flatiron Institute, Simons Foundation, NY, New York, USA.
Soares-Schanoski A; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Vangeti S; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Vasoya M; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Weir DL; Naval Medical Research Center, MD, Silver Spring, USA.
Zaslavsky E; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Kim-Schulze S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA.; Human Immune Monitoring Center (HIMC), Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Gnjatic S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA.; Human Immune Monitoring Center (HIMC), Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Merad M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA.; Human Immune Monitoring Center (HIMC), Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Letizia AG; Naval Medical Research Center, MD, Silver Spring, USA.
Troyanskaya OG; Center for Computational Biology, Flatiron Institute, Simons Foundation, NY, New York, USA.; Department of Computer Science, Princeton University, NJ, Princeton, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ, Princeton, USA.
Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Chikina M; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, PA, Pittsburgh, USA.
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Corporate Authors:
Biobank Team; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, NY, New York, USA.; Human Immune Monitoring Center (HIMC), Icahn School of Medicine at Mount Sinai, NY, New York, USA.
Źródło:
Molecular systems biology [Mol Syst Biol] 2023 May 09; Vol. 19 (5), pp. e11361. Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
COVID-19*/genetics
Young Adult ; Humans ; SARS-CoV-2/genetics ; Prospective Studies ; DNA Methylation/genetics ; Protein Processing, Post-Translational
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correction: Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.
Autorzy:
Ledo JH
Zhang R
Mesin L
Mourão-Sá D
Azevedo EP
Silva HM
Troyanskaya OG
Bustos V
Greengard P
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Źródło:
PloS one [PLoS One] 2021 Feb 19; Vol. 16 (2), pp. e0247680. Date of Electronic Publication: 2021 Feb 19 (Print Publication: 2021).
Typ publikacji:
Published Erratum
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.
Autorzy:
Ledo JH; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America.
Zhang R; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Mesin L; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, New York, United States of America.
Mourão-Sá D; Laboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, New York, New York, United States of America.
Azevedo EP; Laboratory of Molecular Genetics, The Rockefeller University, New York, New York, United States of America.
Troyanskaya OG; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.; Flatiron Institute, Simons Foundation, New York, New York, United States of America.
Bustos V; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America.
Greengard P; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Aug 21; Vol. 15 (8), pp. e0237773. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
Microglia/*physiology
Presenilin-1/*metabolism
Stem Cells/*metabolism
Animals ; Brain/embryology ; Brain/metabolism ; Female ; Male ; Mice, Inbred C57BL ; Phosphorylation ; Presenilin-1/genetics ; Stem Cells/cytology ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development.
Autorzy:
Zhou J; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.; Graduate Program in Quantitative and Computational Biology, Princeton University, Princeton, New Jersey, United States of America.; Center for Computational Biology, Flatiron Institute, New York, New York, United States of America.
Schor IE; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Yao V; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.; Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America.
Theesfeld CL; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Marco-Ferreres R; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Tadych A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Furlong EEM; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Troyanskaya OG; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.; Center for Computational Biology, Flatiron Institute, New York, New York, United States of America.; Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2019 Sep 25; Vol. 15 (9), pp. e1008382. Date of Electronic Publication: 2019 Sep 25 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling/*methods
Gene Expression Regulation, Developmental/*genetics
Genome-Wide Association Study/*methods
Algorithms ; Animals ; Computational Biology/methods ; Computer Simulation ; Drosophila/genetics ; Embryonic Development/genetics ; Forecasting/methods ; Gene Expression Regulation, Developmental/physiology ; Genes, Developmental/genetics ; Machine Learning ; Spatio-Temporal Analysis ; Transcriptome/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression.
Autorzy:
Kaletsky R; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Yao V; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.; Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America.
Williams A; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Runnels AM; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Tadych A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Zhou S; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Troyanskaya OG; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.; Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America.; Flatiron Institute, Simons Foundation, New York, New York, United States of America.
Murphy CT; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2018 Aug 10; Vol. 14 (8), pp. e1007559. Date of Electronic Publication: 2018 Aug 10 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
Caenorhabditis elegans/*genetics
Caenorhabditis elegans Proteins/*genetics
Alternative Splicing ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Gene Library ; Insulin/metabolism ; Insulin-Like Growth Factor I/metabolism ; Models, Molecular ; Phenotype ; Protein Isoforms ; Sequence Analysis, RNA ; Signal Transduction ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A global genetic interaction network maps a wiring diagram of cellular function.
Autorzy:
Costanzo M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
VanderSluis B; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. Simons Center for Data Analysis, Simons Foundation, 160 Fifth Avenue, New York, NY 10010, USA.
Koch EN; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Baryshnikova A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Pons C; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Tan G; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Wang W; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Usaj M; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Hanchard J; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Lee SD; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Pelechano V; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Styles EB; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Billmann M; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany.
van Leeuwen J; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
van Dyk N; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Lin ZY; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto ON, Canada.
Kuzmin E; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Nelson J; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. Program in Biomedical Informatics and Computational Biology, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Piotrowski JS; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Sciences (CSRS), Saitama, Japan.
Srikumar T; Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto ON, Canada.
Bahr S; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Chen Y; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Deshpande R; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Kurat CF; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Li SC; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Sciences (CSRS), Saitama, Japan.
Li Z; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Usaj MM; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Okada H; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan 277-8561.
Pascoe N; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
San Luis BJ; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Sharifpoor S; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Shuteriqi E; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Simpkins SW; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. Program in Biomedical Informatics and Computational Biology, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Snider J; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Suresh HG; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Tan Y; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Zhu H; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Malod-Dognin N; Computer Science Deptartment, University College London, London WC1E 6BT, UK.
Janjic V; Department of Computing, Imperial College London, UK.
Przulj N; Computer Science Deptartment, University College London, London WC1E 6BT, UK. School of Computing (RAF), Union University, Belgrade, Serbia.
Troyanskaya OG; Simons Center for Data Analysis, Simons Foundation, 160 Fifth Avenue, New York, NY 10010, USA. Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Stagljar I; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Xia T; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China, 430074.
Ohya Y; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan 277-8561.
Gingras AC; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto ON, Canada.
Raught B; Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto ON, Canada.
Boutros M; Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany.
Steinmetz LM; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany. Department of Genetics, School of Medicine and Stanford Genome Technology Center Stanford University, Palo Alto, CA 94304, USA.
Moore CL; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Rosebrock AP; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Caudy AA; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1.
Myers CL; Department of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. Program in Biomedical Informatics and Computational Biology, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA. .
Andrews B; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. .
Boone C; The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto ON, Canada M5S 3E1. Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Sciences (CSRS), Saitama, Japan. .
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Źródło:
Science (New York, N.Y.) [Science] 2016 Sep 23; Vol. 353 (6306).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Regulatory Networks*
Genes, Fungal/*physiology
Genetic Pleiotropy/*physiology
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Epistasis, Genetic ; Genes, Essential
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Predicting effects of noncoding variants with deep learning-based sequence model.
Autorzy:
Zhou J; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.; Graduate Program in Quantitative and Computational Biology, Princeton University, Princeton, New Jersey, USA.
Troyanskaya OG; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.; Department of Computer Science, Princeton University, Princeton, New Jersey, USA.; Simons Center for Data Analysis, Simons Foundation, New York, New York, USA.
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Źródło:
Nature methods [Nat Methods] 2015 Oct; Vol. 12 (10), pp. 931-4. Date of Electronic Publication: 2015 Aug 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Algorithms*
Polymorphism, Single Nucleotide*
Quantitative Trait Loci*
Chromatin/*genetics
Epigenomics ; Genome, Human ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Humans ; Models, Genetic ; Mutation ; RNA, Untranslated ; Regulatory Sequences, Nucleic Acid ; Support Vector Machine ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Understanding multicellular function and disease with human tissue-specific networks.
Autorzy:
Greene CS; 1] Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. [2] Dartmouth-Hitchcock Norris Cotton Cancer Center, Lebanon, New Hampshire, USA. [3] Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA.
Krishnan A; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Wong AK; Department of Computer Science, Princeton University, Princeton, New Jersey, USA.
Ricciotti E; 1] Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [2] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Zelaya RA; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Himmelstein DS; Biology and Medical Informatics, University of California, San Francisco, San Francisco, California, USA.
Zhang R; Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Hartmann BM; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Zaslavsky E; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
FitzGerald GA; 1] Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [2] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Dolinski K; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Grosser T; 1] Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [2] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Troyanskaya OG; 1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [2] Department of Computer Science, Princeton University, Princeton, New Jersey, USA. [3] Simons Center for Data Analysis, Simons Foundation, New York, New York, USA.
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Źródło:
Nature genetics [Nat Genet] 2015 Jun; Vol. 47 (6), pp. 569-76. Date of Electronic Publication: 2015 Apr 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
Protein Interaction Maps*
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Bayes Theorem ; Cells, Cultured ; Gene Expression Regulation ; Gene Ontology ; Genome-Wide Association Study ; Humans ; Hypertension/genetics ; Hypertension/metabolism ; Models, Biological ; Myocytes, Smooth Muscle/physiology ; Organ Specificity ; Parkinson Disease/genetics ; Parkinson Disease/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Targeted exploration and analysis of large cross-platform human transcriptomic compendia.
Autorzy:
Zhu Q; 1] Department of Computer Science, Princeton University, Princeton, New Jersey, USA. [2] Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Wong AK; 1] Department of Computer Science, Princeton University, Princeton, New Jersey, USA. [2] Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Krishnan A; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Aure MR; Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway.
Tadych A; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, USA.
Zhang R; 1] Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Corney DC; 1] Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Greene CS; 1] Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. [2] Institute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, New Hampshire, USA.
Bongo LA; Department of Computer Science, University of Tromsø, Tromsø, Norway.
Kristensen VN; 1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway. [2] Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. [3] Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Akershus University Hospital, Akershus, Norway.
Charikar M; Department of Computer Science, Princeton University, Princeton, New Jersey, USA.
Li K; Department of Computer Science, Princeton University, Princeton, New Jersey, USA.
Troyanskaya OG; 1] Department of Computer Science, Princeton University, Princeton, New Jersey, USA. [2] Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, New Jersey, USA. [3] Simons Center for Data Analysis, Simons Foundation, New York, New York, USA.
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Źródło:
Nature methods [Nat Methods] 2015 Mar; Vol. 12 (3), pp. 211-4, 3 p following 214. Date of Electronic Publication: 2015 Jan 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
High-Throughput Nucleotide Sequencing*
Search Engine*
Transcriptome*
Algorithms ; Databases, Genetic ; Gene Ontology ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Humans ; RNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Global quantitative modeling of chromatin factor interactions.
Autorzy:
Zhou J; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America; Graduate Program in Quantitative and Computational Biology, Princeton University, Princeton, New Jersey, United States of America.
Troyanskaya OG; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America; Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2014 Mar 27; Vol. 10 (3), pp. e1003525. Date of Electronic Publication: 2014 Mar 27 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromatin/*chemistry
Algorithms ; Animals ; Area Under Curve ; Computational Biology ; Drosophila melanogaster ; Entropy ; Gene Expression Regulation ; Histones/chemistry ; Models, Statistical ; Normal Distribution ; Probability ; Reproducibility of Results ; Systems Biology ; Transcription Factors/metabolism ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Comparative gene expression between two yeast species.
Autorzy:
Guan Y; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Dunham MJ
Troyanskaya OG
Caudy AA
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Źródło:
BMC genomics [BMC Genomics] 2013 Jan 16; Vol. 14, pp. 33. Date of Electronic Publication: 2013 Jan 16.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Expression Profiling*
Saccharomyces cerevisiae/*genetics
Evolution, Molecular ; Gene Expression Regulation, Fungal ; Genetic Variation ; Species Specificity ; Statistics as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Functional knowledge transfer for high-accuracy prediction of under-studied biological processes.
Autorzy:
Park CY; Department of Computer Science, Princeton University, Princeton, New Jersey, USA.
Wong AK
Greene CS
Rowland J
Guan Y
Bongo LA
Burdine RD
Troyanskaya OG
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2013; Vol. 9 (3), pp. e1002957. Date of Electronic Publication: 2013 Mar 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Biological Phenomena*
Models, Biological*
Computational Biology/*methods
Animals ; Bayes Theorem ; Caenorhabditis elegans ; Drosophila melanogaster ; Embryo, Nonmammalian ; Embryonic Development ; Genes ; Humans ; Mice ; Models, Statistical ; Rats ; Sequence Analysis, DNA ; Support Vector Machine ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Accurate evaluation and analysis of functional genomics data and methods.
Autorzy:
Greene CS; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. />Troyanskaya OG
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2012 Jul; Vol. 1260, pp. 95-100. Date of Electronic Publication: 2012 Jan 23.
Typ publikacji:
Evaluation Study; Journal Article
MeSH Terms:
Genomics/*methods
Algorithms ; Bias ; Databases, Genetic/standards ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chapter 2: Data-driven view of disease biology.
Autorzy:
Greene CS; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America.
Troyanskaya OG
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2012; Vol. 8 (12), pp. e1002816. Date of Electronic Publication: 2012 Dec 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Disease*
Bayes Theorem ; Cell Line ; Genome, Human ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tissue-specific functional networks for prioritizing phenotype and disease genes.
Autorzy:
Guan Y; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Gorenshteyn D
Burmeister M
Wong AK
Schimenti JC
Handel MA
Bult CJ
Hibbs MA
Troyanskaya OG
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2012; Vol. 8 (9), pp. e1002694. Date of Electronic Publication: 2012 Sep 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Models, Biological*
Genetic Predisposition to Disease/*genetics
Organ Specificity/*genetics
Protein Interaction Mapping/*methods
Proteome/*genetics
Proteome/*metabolism
Signal Transduction/*genetics
Animals ; Computer Simulation ; Humans ; Mice ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Nucleosome-coupled expression differences in closely-related species.
Autorzy:
Guan Y; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.
Yao V
Tsui K
Gebbia M
Dunham MJ
Nislow C
Troyanskaya OG
Pokaż więcej
Źródło:
BMC genomics [BMC Genomics] 2011 Sep 26; Vol. 12, pp. 466. Date of Electronic Publication: 2011 Sep 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Expression Regulation, Fungal*
Nucleosomes/*metabolism
Saccharomyces/*metabolism
Saccharomyces cerevisiae/*metabolism
Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Saccharomyces/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Species Specificity ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Accurate quantification of functional analogy among close homologs.
Autorzy:
Chikina MD; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.
Troyanskaya OG
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2011 Feb 03; Vol. 7 (2), pp. e1001074. Date of Electronic Publication: 2011 Feb 03.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Evolution, Molecular*
Sequence Homology, Amino Acid*
Structural Homology, Protein*
Animals ; Bayes Theorem ; Computational Biology ; Gene Expression Profiling/statistics & numerical data ; Gene Regulatory Networks ; Humans ; Lamins/chemistry ; Lamins/genetics ; Lamins/physiology ; Oligonucleotide Array Sequence Analysis/statistics & numerical data ; Proteins/chemistry ; Proteins/genetics ; Proteins/physiology ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/physiology ; Species Specificity ; Superoxide Dismutase/chemistry ; Superoxide Dismutase/genetics ; Superoxide Dismutase/physiology ; Synaptosomal-Associated Protein 25/chemistry ; Synaptosomal-Associated Protein 25/genetics ; Synaptosomal-Associated Protein 25/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 41

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