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Tytuł :
In vivo analysis of trypanocidal drug resistance in sahelian goats infected by Trypanosoma vivax strains collected in northern Togo.
Autorzy :
Boma S; Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Unité de Recherche Maladies à Vecteurs et Biodiversité (UMaVeB), 01P.O. Box. 454 Bobo-Dioulasso 01, Burkina Faso. Electronic address: .
Vitouley SH; Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Unité de Recherche Maladies à Vecteurs et Biodiversité (UMaVeB), 01P.O. Box. 454 Bobo-Dioulasso 01, Burkina Faso; Université Nazi BONI (UNB), 01 BP 1 091 Bobo-Dioulasso 01, Burkina Faso.
Somda MB; Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Unité de Recherche Maladies à Vecteurs et Biodiversité (UMaVeB), 01P.O. Box. 454 Bobo-Dioulasso 01, Burkina Faso; Université Nazi BONI (UNB), 01 BP 1 091 Bobo-Dioulasso 01, Burkina Faso.
Bengaly Z; Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Unité de Recherche Maladies à Vecteurs et Biodiversité (UMaVeB), 01P.O. Box. 454 Bobo-Dioulasso 01, Burkina Faso.
Houaga I; Centre for Tropical Livestock Genetics and Health (CTLGH), The Roslin Institute, University of Edinburgh, EH25 9RG, UK.
Lombo Y; Institut Togolais de Recherche Agronomique (ITRA-Togo), Programme production et santé animale, BP: 1163 Lomé-Cacavéli, Togo.
Tchamdja E; Institut Togolais de Recherche Agronomique (ITRA-Togo), Programme production et santé animale, BP: 1163 Lomé-Cacavéli, Togo.
Dayo GK; Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), Unité de Recherche Maladies à Vecteurs et Biodiversité (UMaVeB), 01P.O. Box. 454 Bobo-Dioulasso 01, Burkina Faso.
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Źródło :
Veterinary parasitology [Vet Parasitol] 2022 Jun; Vol. 306, pp. 109723. Date of Electronic Publication: 2022 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Goat Diseases*/drug therapy
Trypanocidal Agents*/pharmacology
Trypanocidal Agents*/therapeutic use
Trypanosoma*
Trypanosomiasis, African*/drug therapy
Trypanosomiasis, African*/epidemiology
Trypanosomiasis, African*/veterinary
Animals ; Goats ; Togo/epidemiology ; Trypanosoma vivax
Czasopismo naukowe
Tytuł :
Genetic connectivity of trypanosomes between tsetse-infested and tsetse-free areas of Kenya.
Autorzy :
Kimenyi NN; International Center for Insect Physiology and Ecology (icipe), P. O. Box 30772, Nairobi00100, Kenya.; School of Biological Sciences, The University of Nairobi, Nairobi, Kenya.
Kimenyi KM; Center for Biotechnology and Bioinformatics (CEBIB), The University of Nairobi, Nairobi, Kenya.
Amugune NO; School of Biological Sciences, The University of Nairobi, Nairobi, Kenya.
Getahun MN; International Center for Insect Physiology and Ecology (icipe), P. O. Box 30772, Nairobi00100, Kenya.
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Źródło :
Parasitology [Parasitology] 2022 Mar; Vol. 149 (3), pp. 285-297. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma*/genetics
Trypanosoma brucei brucei*/genetics
Trypanosoma congolense*/genetics
Trypanosomiasis, African*/epidemiology
Tsetse Flies*
Animals ; Kenya/epidemiology ; Trypanosoma vivax/genetics
Czasopismo naukowe
Tytuł :
Black-necked spitting cobra (Naja nigricollis) phospholipases A 2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket.
Autorzy :
Martos-Esteban A; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Macleod OJS; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Maudlin I; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Kalogeropoulos K; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Jürgensen JA; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Carrington M; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. .
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Źródło :
Scientific reports [Sci Rep] 2022 Apr 16; Vol. 12 (1), pp. 6394. Date of Electronic Publication: 2022 Apr 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma brucei brucei*/metabolism
Animals ; Elapid Venoms/metabolism ; Endocytosis ; Humans ; Mammals/metabolism ; Naja ; Phospholipases A2/metabolism ; Variant Surface Glycoproteins, Trypanosoma/metabolism
Czasopismo naukowe
Tytuł :
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
Autorzy :
Smith A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Wall RJ; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Patterson S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Rowan T; GALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 0PZ, United Kingdom.
Rico Vidal E; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Huggett M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Hampton SE; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Thomas MG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Corpas Lopez V; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Gillingwater K; Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland.; University of Basel, Petersplatz 1, CH-4001 Basel, Switzerland.
Duke J; University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB United Kingdom.
Napier G; GALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 0PZ, United Kingdom.
Peter R; GALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 0PZ, United Kingdom.
Vitouley HS; Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES), No 559 ru 5-31 angle Av. du Gouverneur Louveau, 01 BP: 454 Bobo-Dioulasso 01, Burkina Faso.
Harrison JR; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Milne R; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Jeacock L; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Baker N; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Davis SH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Simeons F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Horn D; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Brun R; Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland.; University of Basel, Petersplatz 1, CH-4001 Basel, Switzerland.
Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Witty MJ; GALVmed, Doherty Building, Pentlands Science Park, Bush Loan, Penicuik, Edinburgh EH26 0PZ, United Kingdom.
Wyllie S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5606-5624. Date of Electronic Publication: 2022 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma congolense*
Trypanosomiasis, African*/drug therapy
Trypanosomiasis, African*/parasitology
Trypanosomiasis, African*/veterinary
Animals ; Cattle ; Cyclin-Dependent Kinases ; Drug Repositioning ; Trypanosoma vivax
Czasopismo naukowe
Tytuł :
Homology modelling of Trypanosoma brucei major surface proteases and molecular docking of variant surface glycoproteins and inhibitor ligands for drug design.
Autorzy :
Marufu L; Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Pietermaritzburg Campus), Private Bag X01, Scottsville, 3209, South Africa.
Coetzer THT; Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Pietermaritzburg Campus), Private Bag X01, Scottsville, 3209, South Africa. Electronic address: .
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2022 Mar; Vol. 111, pp. 108104. Date of Electronic Publication: 2021 Dec 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma brucei brucei*
Animals ; Drug Design ; Ligands ; Membrane Glycoproteins ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peptide Hydrolases ; Variant Surface Glycoproteins, Trypanosoma
Czasopismo naukowe
Tytuł :
Distinct APOL1 functions in trypanosomes and kidney podocytes.
Autorzy :
Pays E; Laboratory of Molecular Parasitology, Institute of Molecular Biology and Medicine, Université Libre de Bruxelles, Gosselies, Belgium. Electronic address: .
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Źródło :
Trends in parasitology [Trends Parasitol] 2022 Feb; Vol. 38 (2), pp. 104-108. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Kidney Diseases*/metabolism
Podocytes*/metabolism
Trypanosoma*
Trypanosomiasis, African*
Animals ; Apolipoprotein L1/genetics ; Apolipoprotein L1/metabolism ; Humans ; Trypanosoma brucei rhodesiense
Czasopismo naukowe
Tytuł :
Evolution of the variant surface glycoprotein family in African trypanosomes.
Autorzy :
Silva Pereira S; Instituto de Medicina Molecular - João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Jackson AP; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, UK.
Figueiredo LM; Instituto de Medicina Molecular - João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. Electronic address: .
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Źródło :
Trends in parasitology [Trends Parasitol] 2022 Jan; Vol. 38 (1), pp. 23-36. Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Trypanosoma*
Trypanosoma brucei brucei*/genetics
Trypanosomiasis, African*/parasitology
Animals ; Antigenic Variation/genetics ; Membrane Glycoproteins/genetics ; Variant Surface Glycoproteins, Trypanosoma/genetics ; Variant Surface Glycoproteins, Trypanosoma/metabolism
Czasopismo naukowe
Tytuł :
First molecular survey of animal trypanosomes in Paraguayan horses.
Autorzy :
Suganuma K; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan. Electronic address: .
Acosta TJ; Field Center of Animal Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan; Universidad Nacional de Canendiyu, Salto del Guaira, Paraguay. Electronic address: .
Valinotti MFR; Centro de Diagnostico Veterinario, San Lorenzo, Paraguay. Electronic address: .
Sanchez AR; Centro de Diagnostico Veterinario, San Lorenzo, Paraguay. Electronic address: .
Mossaad E; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan.
Elata A; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan.
Inoue N; Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido, Japan. Electronic address: .
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Źródło :
Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2022 Jan; Vol. 27, pp. 100664. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Horse Diseases*/epidemiology
Trypanosoma*/genetics
Trypanosomiasis*/epidemiology
Trypanosomiasis*/veterinary
Animals ; Cross-Sectional Studies ; Horses ; Polymerase Chain Reaction/veterinary ; Trypanosoma vivax
Czasopismo naukowe
Tytuł :
No more cold-chain failures, using dehydrated reagents in ELISA antibody-detection against animal trypanosomes of African origin.
Autorzy :
Bossard G; CIRAD, UMR INTERTRYP, F-34398, Montpellier, France; INTERTRYP, Univ Montpellier, CIRAD, IRD, Montpellier, France. Electronic address: .
Millogo L; CIRDES (Centre International de Recherche-Développement sur l'Elevage en zone Subhumide), Bobo-Dioulasso, Burkina Faso.
Thévenon S; CIRAD, UMR INTERTRYP, F-34398, Montpellier, France; INTERTRYP, Univ Montpellier, CIRAD, IRD, Montpellier, France.
Vitouley H; CIRDES (Centre International de Recherche-Développement sur l'Elevage en zone Subhumide), Bobo-Dioulasso, Burkina Faso.
Bengaly Z; CIRDES (Centre International de Recherche-Développement sur l'Elevage en zone Subhumide), Bobo-Dioulasso, Burkina Faso.
Desquesnes M; INTERTRYP, Univ Montpellier, CIRAD, IRD, Montpellier, France; CIRAD, UMR INTERTRYP, Bangkok, Thailand; Faculty of Veterinary Medicine, Kasetsart University, 10900, Bangkok, Thailand.
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Źródło :
Veterinary parasitology [Vet Parasitol] 2021 Nov; Vol. 299, pp. 109568. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article
MeSH Terms :
Trypanosoma*
Trypanosoma congolense*
Trypanosomiasis, African*/diagnosis
Trypanosomiasis, African*/veterinary
Animals ; Enzyme-Linked Immunosorbent Assay/veterinary ; Indicators and Reagents ; Mammals ; Reproducibility of Results ; Trypanosoma vivax
Czasopismo naukowe
Tytuł :
Should the enzyme name 'rhodesain' be discontinued?
Autorzy :
Steverding D; Bob Champion Research and Education Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom. Electronic address: .
Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
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Źródło :
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2021 Sep; Vol. 245, pp. 111395. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Trypanosoma brucei brucei*
Trypanosomiasis, African*
Amino Acid Sequence ; Animals ; Cysteine Endopeptidases ; Peptide Hydrolases ; Trypanosoma brucei rhodesiense
Czasopismo naukowe
Tytuł :
First identification of Trypanosoma vivax among camels (Camelus dromedarius) in Yazd, central Iran, jointly with Trypanosoma evansi.
Autorzy :
Asghari MM; Pathobiology Department of Veterinary Faculty, Semnan University, Semnan, Iran.
Rassouli M; Pathobiology Department of Veterinary Faculty, Semnan University, Semnan, Iran; Pathobiology Department of Shahmirzad School of Veterinary Medicine, Semnan University, Semnan, Iran. Electronic address: .
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Źródło :
Parasitology international [Parasitol Int] 2022 Feb; Vol. 86, pp. 102450. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Camelus*
Trypanosoma vivax/*isolation & purification
Trypanosomiasis/*veterinary
Animals ; Iran/epidemiology ; Male ; Prevalence ; Trypanosoma/isolation & purification ; Trypanosomiasis/epidemiology ; Trypanosomiasis/parasitology
Czasopismo naukowe
Tytuł :
Shedding of Trypanosoma cruzi Surface Molecules That Regulate Host Cell Invasion Involves Phospholipase C and Increases Upon Sterol Depletion.
Autorzy :
Loch L; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Onofre TS; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Rodrigues JPF; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Yoshida N; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Oct 19; Vol. 11, pp. 769722. Date of Electronic Publication: 2021 Oct 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma cruzi*
HeLa Cells ; Humans ; Protozoan Proteins ; Sterols ; Type C Phospholipases ; Variant Surface Glycoproteins, Trypanosoma
Czasopismo naukowe
Tytuł :
POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes.
Autorzy :
Rabbani MAG; Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA.
Tonini ML; Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA.
Afrin M; Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA.
Li B; Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA.; Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195, USA.; Center for RNA Science and Therapeutics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2022 Feb 28; Vol. 50 (4), pp. 2036-2050.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Telomerase*/genetics
Telomerase*/metabolism
Telomere*/genetics
Telomere*/metabolism
Trypanosoma/*metabolism
DNA/metabolism ; Humans ; Trypanosoma/genetics ; Variant Surface Glycoproteins, Trypanosoma/genetics
Czasopismo naukowe
Tytuł :
The role of glycosylphosphatidylinositol phospholipase C in membrane trafficking in Trypanosoma brucei.
Autorzy :
Garrison P; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY, 14214, USA.
Umaer K; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY, 14214, USA.
Bangs JD; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), Buffalo, NY, 14214, USA. Electronic address: .
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Źródło :
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2021 Sep; Vol. 245, pp. 111409. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma brucei brucei*/metabolism
Glycosylphosphatidylinositols/metabolism ; Lysosomes/metabolism ; Protein Transport ; Type C Phospholipases/metabolism ; Variant Surface Glycoproteins, Trypanosoma/metabolism
Czasopismo naukowe
Tytuł :
First report of Trypanosoma vivax infection in sheep from Nicaragua.
Autorzy :
Bonilla JL; Centro Veterinario de Diagnóstico e Investigación (CEVEDI), Departamento de Veterinaria y Zootecnia, Escuela de Ciencias Agrarias y Veterinarias, Universidad Nacional Autónoma de Nicaragua-León (UNAN-León), Carretera a La Ceiba 1 Km al Este, León 21000, 9, Nicaragua.
Oliveira JB; Laboratório de Parasitologia, Departamento de Biologia, Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manoel de Medeiros SN, Recife CEP 52171-900, 12 Pernambuco, Brazil; Cátedra Parasitología y Enfermedades Parasitarias, Escuela de Medicina Veterinaria, Universidad Nacional, APDO 86-3000, Barreal de Heredia, Heredia, Costa Rica.
Flores B; Centro Veterinario de Diagnóstico e Investigación (CEVEDI), Departamento de Veterinaria y Zootecnia, Escuela de Ciencias Agrarias y Veterinarias, Universidad Nacional Autónoma de Nicaragua-León (UNAN-León), Carretera a La Ceiba 1 Km al Este, León 21000, 9, Nicaragua. Electronic address: .
Jirón W; Centro Veterinario de Diagnóstico e Investigación (CEVEDI), Departamento de Veterinaria y Zootecnia, Escuela de Ciencias Agrarias y Veterinarias, Universidad Nacional Autónoma de Nicaragua-León (UNAN-León), Carretera a La Ceiba 1 Km al Este, León 21000, 9, Nicaragua.
Sheleby-Elías J; Centro Veterinario de Diagnóstico e Investigación (CEVEDI), Departamento de Veterinaria y Zootecnia, Escuela de Ciencias Agrarias y Veterinarias, Universidad Nacional Autónoma de Nicaragua-León (UNAN-León), Carretera a La Ceiba 1 Km al Este, León 21000, 9, Nicaragua.
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Źródło :
Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2021 Jul; Vol. 25, pp. 100602. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cattle Diseases*/parasitology
Sheep Diseases*/epidemiology
Sheep Diseases*/parasitology
Trypanosoma*
Trypanosomiasis*/veterinary
Animals ; Cattle ; Female ; Male ; Nicaragua/epidemiology ; Sheep ; Trypanosoma vivax/genetics
Czasopismo naukowe
Tytuł :
Diaryl Ureas as an Antiprotozoal Chemotype.
Autorzy :
Leas DA; College of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198-6125, United States.
Sanford AG; Department of Pathology & Microbiology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska 68198-5900, United States.; Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
Wu J; College of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198-6125, United States.
Cal M; University of Basel, CH-4003 Basel, Switzerland.; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
Kaiser M; University of Basel, CH-4003 Basel, Switzerland.; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
Wittlin S; University of Basel, CH-4003 Basel, Switzerland.; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.
Hemsley RM; Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
Darner EB; Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
Lui LM; Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
Davis PH; Department of Biology, University of Nebraska at Omaha, 6001 Dodge Street, Omaha, Nebraska 68182, United States.
Vennerstrom JL; College of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198-6125, United States.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2021 Jun 11; Vol. 7 (6), pp. 1578-1583. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiprotozoal Agents*/pharmacology
Leishmania donovani*
Trypanosoma cruzi*
Animals ; Mice ; Trypanosoma brucei rhodesiense ; Urea
Czasopismo naukowe
Tytuł :
CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes.
Autorzy :
Kovářová J; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Novotná M; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Faria J; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Rico E; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Wallace C; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Zoltner M; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Field MC; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Branišovská 31, 37005 České Budějovice, Czech Republic.
Horn D; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address: .
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Źródło :
Molecular and biochemical parasitology [Mol Biochem Parasitol] 2022 May; Vol. 249, pp. 111476. Date of Electronic Publication: 2022 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma*/genetics
Trypanosoma brucei brucei*/genetics
CRISPR-Cas Systems ; Genes, Essential ; Untranslated Regions
Czasopismo naukowe
Tytuł :
Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1.
Autorzy :
Llanos MA; Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata - 47 and 115, La Plata, Buenos Aires, Argentina.
Alberca LN; Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata - 47 and 115, La Plata, Buenos Aires, Argentina.; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina.
Larrea SCV; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina.
Schoijet AC; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina.
Alonso GD; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina.
Bellera CL; Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata - 47 and 115, La Plata, Buenos Aires, Argentina.; National Scientific and Technical Research Council (CONICET) - CCT, La Plata, Argentina.
Gavenet L; Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata - 47 and 115, La Plata, Buenos Aires, Argentina.; National Scientific and Technical Research Council (CONICET) - CCT, La Plata, Argentina.
Talevi A; Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata - 47 and 115, La Plata, Buenos Aires, Argentina.; National Scientific and Technical Research Council (CONICET) - CCT, La Plata, Argentina.
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Źródło :
Chemistry & biodiversity [Chem Biodivers] 2022 Jan; Vol. 19 (1), pp. e202100712. Date of Electronic Publication: 2021 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
3',5'-Cyclic-AMP Phosphodiesterases/*chemistry
Protozoan Proteins/*chemistry
Small Molecule Libraries/*chemistry
Trypanosoma cruzi/*enzymology
3',5'-Cyclic-AMP Phosphodiesterases/metabolism ; Amino Acid Sequence ; Area Under Curve ; Binding Sites ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Structure, Tertiary ; Protozoan Proteins/metabolism ; ROC Curve ; Sequence Alignment ; Small Molecule Libraries/metabolism ; Trypanosoma brucei brucei/enzymology
Czasopismo naukowe
Tytuł :
A distinct complex of PRP19-related and trypanosomatid-specific proteins is required for pre-mRNA splicing in trypanosomes.
Autorzy :
Srivastava A; Department of Genetics and Genome Sciences, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030-6403, USA.
Ambrósio DL; Department of Genetics and Genome Sciences, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030-6403, USA.; Departamento de Ciências da Biointeração, Universidade Federal da Bahia, Canela, Salvador, 40231-300, Brazil.
Tasak M; Department of Genetics and Genome Sciences, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030-6403, USA.
Gosavi U; Department of Genetics and Genome Sciences, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030-6403, USA.
Günzl A; Department of Genetics and Genome Sciences, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030-6403, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Dec 16; Vol. 49 (22), pp. 12929-12942.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Repair Enzymes/*genetics
Nuclear Proteins/*genetics
Protozoan Proteins/*genetics
RNA Precursors/*genetics
RNA Splicing Factors/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Trypanosoma brucei brucei/*genetics
DNA Repair Enzymes/metabolism ; Humans ; Models, Biological ; Nuclear Proteins/metabolism ; Protein Binding ; Protozoan Proteins/metabolism ; RNA Interference ; RNA Precursors/metabolism ; RNA Splicing ; RNA Splicing Factors/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Protozoan/genetics ; RNA, Protozoan/metabolism ; RNA, Small Nuclear/genetics ; RNA, Small Nuclear/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Spliceosomes/genetics ; Spliceosomes/metabolism ; Trypanosoma/classification ; Trypanosoma/genetics ; Trypanosoma/metabolism ; Trypanosoma brucei brucei/metabolism
Czasopismo naukowe
Tytuł :
Identification and biochemical characterization of an ATP-dependent dihydroxyacetone kinase from Trypanosoma cruzi.
Autorzy :
Viecenz JM; Instituto Nacional de Parasitología 'Dr. Mario Fatala Chaben'-ANLIS 'Dr. Carlos G. Malbrán'. Paseo Colón 568, Buenos Aires, (1063), Argentina.
Garavaglia PA; Instituto Nacional de Parasitología 'Dr. Mario Fatala Chaben'-ANLIS 'Dr. Carlos G. Malbrán'. Paseo Colón 568, Buenos Aires, (1063), Argentina.
Tasso LM; Instituto Nacional de Parasitología 'Dr. Mario Fatala Chaben'-ANLIS 'Dr. Carlos G. Malbrán'. Paseo Colón 568, Buenos Aires, (1063), Argentina.
Maidana CG; Instituto Nacional de Parasitología 'Dr. Mario Fatala Chaben'-ANLIS 'Dr. Carlos G. Malbrán'. Paseo Colón 568, Buenos Aires, (1063), Argentina.
Bautista Cannata JJ; Instituto de Investigaciones Biotecnológicas (IIB-INTECH) 'Dr. Rodolfo A. Ugalde', Universidad Nacional de General San Martín-CONICET, San Martín, (1650), Prov. Buenos Aires, Argentina.
García GA; Instituto Nacional de Parasitología 'Dr. Mario Fatala Chaben'-ANLIS 'Dr. Carlos G. Malbrán'. Paseo Colón 568, Buenos Aires, (1063), Argentina. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Dec; Vol. 231, pp. 108178. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphotransferases (Alcohol Group Acceptor)/*isolation & purification
Trypanosoma cruzi/*enzymology
Amino Acid Sequence ; Animals ; Blotting, Western ; Chlorocebus aethiops ; Dihydroxyacetone/metabolism ; Dihydroxyacetone/toxicity ; Electrophoresis, Polyacrylamide Gel ; Fluorescent Antibody Technique ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Osmoregulation ; Phosphotransferases (Alcohol Group Acceptor)/chemistry ; Phosphotransferases (Alcohol Group Acceptor)/classification ; Trypanosoma brucei brucei/drug effects ; Trypanosoma cruzi/drug effects ; Vero Cells
Czasopismo naukowe

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