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Wyszukujesz frazę ""Trypanosoma brucei brucei"" wg kryterium: Temat


Tytuł :
Eugenia uniflora and Syzygium samarangense extracts exhibit anti-trypanosomal activity: Evidence from in-silico molecular modelling, in vitro, and in vivo studies.
Autorzy :
Abdelfattah MAO; College of Engineering and Technology, American University of the Middle East, Kuwait.
Ibrahim MA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Abdullahi HL; Department of Medical Laboratory Science, Bayero University, Kano, Nigeria.
Aminu R; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Saad SB; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Krstin S; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.
Wink M; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.
Sobeh M; AgroBiosciences Research Division, Mohammed VI Polytechnic University, Lot 660-Hay Moulay Rachid, 43150 Ben-Guerir, Morocco. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111508. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Eugenia*
Syzygium*
Plant Extracts/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; MCF-7 Cells ; Male ; Models, Molecular ; Molecular Docking Simulation/methods ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use ; Protein Structure, Secondary ; Rats ; Rats, Wistar ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/isolation & purification ; Trypanocidal Agents/therapeutic use ; Trypanosoma brucei brucei/chemistry ; Trypanosomiasis/drug therapy ; Trypanosomiasis/pathology
Czasopismo naukowe
Tytuł :
Guide RNA Repertoires in the Main Lineages of Trypanosoma cruzi : High Diversity and Variable Redundancy Among Strains.
Autorzy :
Rusman F; Unidad de Epidemiología Molecular (UEM), Instituto de Patología Experimental, Universidad Nacional de Salta-CONICET, Salta, Argentina.
Floridia-Yapur N; Unidad de Epidemiología Molecular (UEM), Instituto de Patología Experimental, Universidad Nacional de Salta-CONICET, Salta, Argentina.
Tomasini N; Unidad de Epidemiología Molecular (UEM), Instituto de Patología Experimental, Universidad Nacional de Salta-CONICET, Salta, Argentina.
Diosque P; Unidad de Epidemiología Molecular (UEM), Instituto de Patología Experimental, Universidad Nacional de Salta-CONICET, Salta, Argentina.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 May 31; Vol. 11, pp. 663416. Date of Electronic Publication: 2021 May 31 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chagas Disease*
Trypanosoma brucei brucei*/genetics
Trypanosoma cruzi*/genetics
Base Sequence ; DNA, Kinetoplast ; Humans ; RNA, Guide
Czasopismo naukowe
Tytuł :
Design and synthesis of N-(3-sulfamoylphenyl)amides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors.
Autorzy :
Li Z; State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Xin W; State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Wang Q; State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Zhu M; State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Zhou H; State Key Laboratory of Microbial Metabolism, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 May 05; Vol. 217, pp. 113319. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Amides/*pharmacology
Antiprotozoal Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Leucine-tRNA Ligase/*antagonists & inhibitors
Trypanosoma brucei brucei/*drug effects
Amides/chemical synthesis ; Amides/chemistry ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/chemistry ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Leucine-tRNA Ligase/metabolism ; Molecular Structure ; Parasitic Sensitivity Tests ; Structure-Activity Relationship ; Trypanosoma brucei brucei/enzymology
Czasopismo naukowe
Tytuł :
TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei.
Autorzy :
Davies C; Sir Alexander Fleming Building, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
Ooi CP; Sir Alexander Fleming Building, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
Sioutas G; Sir Alexander Fleming Building, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
Hall BS; Sir Alexander Fleming Building, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
Sidhu H; Sir Alexander Fleming Building, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
Butter F; Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany.
Alsford S; London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Wickstead B; School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.
Rudenko G; Sir Alexander Fleming Building, Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Apr 06; Vol. 49 (6), pp. 3242-3262.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protozoan Proteins/*metabolism
Repressor Proteins/*metabolism
Trypanosoma brucei brucei/*genetics
Variant Surface Glycoproteins, Trypanosoma/*genetics
Chromatin/metabolism ; Gene Expression Regulation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Promoter Regions, Genetic ; Protozoan Proteins/genetics ; RNA Interference ; Repressor Proteins/genetics ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei brucei/metabolism ; Variant Surface Glycoproteins, Trypanosoma/metabolism
Czasopismo naukowe
Tytuł :
Depletion of cardiolipin induces major changes in energy metabolism in Trypanosoma brucei bloodstream forms.
Autorzy :
Serricchio M; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Hierro-Yap C; Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
Schädeli D; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Ben Hamidane H; Weill Cornell Medicine - Qatar, Doha, State of Qatar.
Hemphill A; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Graumann J; Weill Cornell Medicine - Qatar, Doha, State of Qatar.; Biomolecular Mass Spectrometry, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Zíková A; Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic.; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
Bütikofer P; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Feb; Vol. 35 (2), pp. e21176. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knockout Techniques*
Cardiolipins/*genetics
Energy Metabolism/*genetics
Trypanosoma brucei brucei/*genetics
Trypanosoma brucei brucei/*metabolism
Adenosine Triphosphate/metabolism ; Cardiolipins/metabolism ; Electron Transport Chain Complex Proteins/metabolism ; Glycerolphosphate Dehydrogenase/metabolism ; Membrane Potential, Mitochondrial/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Mitochondrial Proteins/metabolism ; Organisms, Genetically Modified ; Oxidoreductases/metabolism ; Oxygen Consumption/genetics ; Plant Proteins/metabolism ; Proteome ; Proteomics ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Transferases (Other Substituted Phosphate Groups)/genetics ; Transferases (Other Substituted Phosphate Groups)/metabolism ; Trypanosoma brucei brucei/classification
Czasopismo naukowe
Tytuł :
Update on relevant trypanosome peptidases: Validated targets and future challenges.
Autorzy :
Alvarez VE; Instituto de Investigaciones Biotecnológicas 'Dr. Rodolfo Ugalde', Universidad Nacional de San Martín - IIBIO, UNSAM-CONICET, San Martín, B1650HMP Buenos Aires, Argentina. Electronic address: .
Iribarren PA; Instituto de Investigaciones Biotecnológicas 'Dr. Rodolfo Ugalde', Universidad Nacional de San Martín - IIBIO, UNSAM-CONICET, San Martín, B1650HMP Buenos Aires, Argentina.
Niemirowicz GT; Instituto de Investigaciones Biotecnológicas 'Dr. Rodolfo Ugalde', Universidad Nacional de San Martín - IIBIO, UNSAM-CONICET, San Martín, B1650HMP Buenos Aires, Argentina.
Cazzulo JJ; Instituto de Investigaciones Biotecnológicas 'Dr. Rodolfo Ugalde', Universidad Nacional de San Martín - IIBIO, UNSAM-CONICET, San Martín, B1650HMP Buenos Aires, Argentina.
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2021 Feb; Vol. 1869 (2), pp. 140577. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Peptide Hydrolases/*genetics
Trypanosoma brucei brucei/*genetics
Trypanosoma cruzi/*genetics
Trypanosomiasis, African/*genetics
Animals ; Cathepsin B/genetics ; Cathepsin B/isolation & purification ; Cattle ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/therapeutic use ; Cysteine Proteases/genetics ; Cysteine Proteinase Inhibitors/therapeutic use ; Humans ; Protozoan Proteins/chemistry ; Protozoan Proteins/therapeutic use ; Trypanosoma brucei brucei/enzymology ; Trypanosoma brucei brucei/pathogenicity ; Trypanosoma cruzi/enzymology ; Trypanosoma cruzi/pathogenicity ; Trypanosomiasis, African/enzymology ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Comparative Analysis of Virulence Mechanisms of Trypanosomatids Pathogenic to Humans.
Autorzy :
de Castro Neto AL; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
da Silveira JF; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Mortara RA; Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Apr 16; Vol. 11, pp. 669079. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Chagas Disease*
Leishmaniasis*
Trypanosoma brucei brucei*
Trypanosoma cruzi*
Humans ; Virulence
Czasopismo naukowe
Tytuł :
Trypanosome RNAEditing Substrate Binding Complex integrity and function depends on the upstream action of RESC10.
Autorzy :
Dubey AP; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Tylec BL; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
McAdams NM; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Sortino K; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Read LK; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Apr 06; Vol. 49 (6), pp. 3557-3572.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
RNA Editing*
Protozoan Proteins/*physiology
RNA, Messenger/*metabolism
RNA, Mitochondrial/*metabolism
RNA-Binding Proteins/*physiology
Trypanosoma brucei brucei/*genetics
RNA, Guide/metabolism ; RNA, Messenger/chemistry ; RNA, Mitochondrial/chemistry ; RNA-Binding Proteins/metabolism ; Trypanosoma brucei brucei/growth & development ; Uridine/metabolism
Czasopismo naukowe
Tytuł :
Characterization of the novel mitochondrial genome segregation factor TAP110 in Trypanosoma brucei .
Autorzy :
Amodeo S; Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland.
Kalichava A; Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland.
Fradera-Sola A; Institute of Molecular Biology, 55128 Mainz, Germany.
Bertiaux-Lequoy E; Department of Cell Biology, University of Geneva, Sciences III, 1211 Geneva, Switzerland.
Guichard P; Department of Cell Biology, University of Geneva, Sciences III, 1211 Geneva, Switzerland.
Butter F; Institute of Molecular Biology, 55128 Mainz, Germany.
Ochsenreiter T; Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland .
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Źródło :
Journal of cell science [J Cell Sci] 2021 Mar 08; Vol. 134 (5). Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Mitochondrial*/genetics
Trypanosoma brucei brucei*/genetics
DNA, Kinetoplast/genetics ; Mitochondria ; Protozoan Proteins/genetics
Czasopismo naukowe
Tytuł :
Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline.
Autorzy :
Villafraz O; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France.
Biran M; Univ. Bordeaux, CNRS, Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB), UMR 5536, Bordeaux, France.
Pineda E; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France.
Plazolles N; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France.
Cahoreau E; Toulouse Biotechnology Institute, TBI-INSA de Toulouse INSA/CNRS 5504-UMR INSA/INRA 792, Toulouse, France.; MetaToul-MetaboHub, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France.
Ornitz Oliveira Souza R; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Thonnus M; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France.
Allmann S; Fakultät für Biologie, Genetik, Ludwig-Maximilians-Universität München, Grosshadernerstrasse 2-4, Martinsried, Germany.
Tetaud E; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France.
Rivière L; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France.
Silber AM; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Barrett MP; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Zíková A; Institute of Parasitology, Biology Center, Czech Academy of Sciences, České Budějovice, Czech Republic.
Boshart M; Fakultät für Biologie, Genetik, Ludwig-Maximilians-Universität München, Grosshadernerstrasse 2-4, Martinsried, Germany.
Portais JC; Toulouse Biotechnology Institute, TBI-INSA de Toulouse INSA/CNRS 5504-UMR INSA/INRA 792, Toulouse, France.; MetaToul-MetaboHub, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France.; RESTORE, Université de Toulouse, Inserm U1031, CNRS 5070, UPS, EFS, ENVT, Toulouse, France.
Bringaud F; Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Mar 01; Vol. 17 (3), pp. e1009204. Date of Electronic Publication: 2021 Mar 01 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucose/*metabolism
Proline/*pharmacology
Trypanosoma/*drug effects
Trypanosoma brucei brucei/*drug effects
Tsetse Flies/*drug effects
Animals ; Citric Acid Cycle/drug effects ; Insect Vectors/parasitology ; Oxidation-Reduction/drug effects ; Proline/metabolism ; RNA Interference/physiology ; Trypanosoma/metabolism ; Trypanosoma brucei brucei/metabolism ; Trypanosomiasis, African/drug therapy ; Tsetse Flies/parasitology
Czasopismo naukowe
Tytuł :
A role for hepcidin in the anemia caused by Trypanosoma brucei infection.
Autorzy :
Neves JV; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto; Iron and Innate Immunity, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto
Gomes AC; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto; Iron and Innate Immunity, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto
Costa DM; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto; Parasite Disease, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto
Barroso C; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto; Iron and Innate Immunity, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto; MCBiology Doctoral Program, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto
Vaulont S; INSERM U1016, CNRS UMR 8104, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris
Cordeiro da Silva A; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto; Parasite Disease, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto
Tavares J; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto; Parasite Disease, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto
Rodrigues PNS; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto; Iron and Innate Immunity, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto
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Źródło :
Haematologica [Haematologica] 2021 Mar 01; Vol. 106 (3), pp. 806-818. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia*/etiology
Trypanosoma brucei brucei*
Animals ; Erythropoiesis ; Hepcidins/genetics ; Iron ; Mice
Czasopismo naukowe
Tytuł :
Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.
Autorzy :
Faria J; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.
Luzak V; Department of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany.; Biomedical Center Munich, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Müller LSM; Department of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany.; Biomedical Center Munich, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Brink BG; Department of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany.; Biomedical Center Munich, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Hutchinson S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.; Trypanosome Cell Biology Unit, INSERM U1201, Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France.
Glover L; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.; Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Institut Pasteur, Paris, France.
Horn D; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK. .
Siegel TN; Department of Veterinary Sciences, Experimental Parasitology, Ludwig-Maximilians-Universität München, Munich, Germany. .; Biomedical Center Munich, Department of Physiological Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany. .
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Źródło :
Nature microbiology [Nat Microbiol] 2021 Mar; Vol. 6 (3), pp. 289-300. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Splicing/*genetics
Transcription, Genetic/*genetics
Trypanosoma brucei brucei/*genetics
Variant Surface Glycoproteins, Trypanosoma/*genetics
Antigenic Variation/genetics ; Chromosomes/genetics ; Chromosomes/metabolism ; Gene Expression Regulation ; Genome, Protozoan/genetics ; Multigene Family/genetics ; RNA, Spliced Leader/genetics ; Trypanosoma brucei brucei/immunology
Czasopismo naukowe
Tytuł :
tRNA 3' shortening by LCCR4 as a response to stress in Trypanosoma brucei.
Autorzy :
Cristodero M; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Brogli R; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Joss O; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Schimanski B; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Schneider A; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Polacek N; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 22; Vol. 49 (3), pp. 1647-1661.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA, Transfer/*metabolism
Ribonucleases/*metabolism
Stress, Physiological/*genetics
Trypanosoma brucei brucei/*enzymology
Protein Biosynthesis ; RNA, Transfer/chemistry ; Trypanosoma brucei brucei/genetics
Czasopismo naukowe
Tytuł :
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes.
Autorzy :
Mehnert AK; Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Institut Pasteur, 75015, Paris, France.
Prorocic M; Wellcome Center for Integrative Parasitology, Sir Graeme Davis Building, 120 University Place, Glasgow G12 8TA, UK.
Dujeancourt-Henry A; Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Institut Pasteur, 75015, Paris, France.
Hutchinson S; Trypanosome Cell Biology Unit, Department of Parasites and Insect Vectors, Institut Pasteur & INSERM U1201, 75015 Paris, France.
McCulloch R; Wellcome Center for Integrative Parasitology, Sir Graeme Davis Building, 120 University Place, Glasgow G12 8TA, UK.
Glover L; Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, Institut Pasteur, 75015, Paris, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 22; Vol. 49 (3), pp. 1436-1454.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigenic Variation*
Recombinational DNA Repair*
DNA-Binding Proteins/*physiology
MRE11 Homologue Protein/*physiology
Protozoan Proteins/*physiology
Trypanosoma brucei brucei/*genetics
DNA Breaks, Double-Stranded ; Trypanosoma brucei brucei/immunology
Czasopismo naukowe
Tytuł :
Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity.
Autorzy :
Pérez B; Instituto de Investigaciones Biotecnológicas Dr. Rodolfo Ugalde, Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires, Argentina.
Bouvier LA; Instituto de Investigaciones Biotecnológicas Dr. Rodolfo Ugalde, Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires, Argentina.
Cazzulo JJ; Instituto de Investigaciones Biotecnológicas Dr. Rodolfo Ugalde, Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires, Argentina.
Agüero F; Instituto de Investigaciones Biotecnológicas Dr. Rodolfo Ugalde, Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires, Argentina.
Salas-Sarduy E; Instituto de Investigaciones Biotecnológicas Dr. Rodolfo Ugalde, Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires, Argentina .
Alvarez VE; Instituto de Investigaciones Biotecnológicas Dr. Rodolfo Ugalde, Universidad Nacional de San Martín, CONICET, San Martín, Buenos Aires, Argentina .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Feb 17; Vol. 65 (3). Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Chagas Disease*
Trypanocidal Agents*/pharmacology
Trypanosoma brucei brucei*
Trypanosoma cruzi*
Animals ; Chlorocebus aethiops ; Humans ; Plasmodium falciparum ; Vero Cells
Czasopismo naukowe
Tytuł :
Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei.
Autorzy :
Sampaio Guther ML; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Prescott AR; Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Kuettel S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Tinti M; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Ferguson MAJ; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Feb 16; Vol. 15 (2), pp. e0009132. Date of Electronic Publication: 2021 Feb 16 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microbodies/*metabolism
Nucleotides/*biosynthesis
Sugars/*metabolism
Trypanosoma brucei brucei/*metabolism
Life Cycle Stages/physiology ; Microbodies/enzymology ; Trypanosoma brucei brucei/enzymology
Czasopismo naukowe
Tytuł :
A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in Trypanosoma brucei .
Autorzy :
Yagüe-Capilla M; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Armilla (Granada) 18016, Spain.
Castillo-Acosta VM; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Armilla (Granada) 18016, Spain.
Bosch-Navarrete C; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Armilla (Granada) 18016, Spain.
Ruiz-Pérez LM; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Armilla (Granada) 18016, Spain.
González-Pacanowska D; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Científicas, Parque Tecnológico de Ciencias de la Salud, Armilla (Granada) 18016, Spain.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2021 Feb 12; Vol. 7 (2), pp. 318-332. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma brucei brucei*/genetics
Animals ; Homeostasis ; Humans ; Mitochondria ; Pyrimidines ; SAM Domain and HD Domain-Containing Protein 1/genetics
Czasopismo naukowe
Tytuł :
The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast.
Autorzy :
Mokdadi M; Expression Génétique Microbienne, UMR8261 CNRS, Université de Paris, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.; Laboratory of Molecular Epidemiology and Experimental Pathology (LR16IPT04), Institut Pasteur de Tunis, Université de Tunis El Manar, 13 Place Pasteur, BP74 Tunis-Belvédère 1002, Tunisia.; Institut National des Sciences Appliquées et Technologies, Université de Carthage, CEDEX, Tunis 1080, Tunisia.
Abdelkrim YZ; Expression Génétique Microbienne, UMR8261 CNRS, Université de Paris, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.; Laboratory of Molecular Epidemiology and Experimental Pathology (LR16IPT04), Institut Pasteur de Tunis, Université de Tunis El Manar, 13 Place Pasteur, BP74 Tunis-Belvédère 1002, Tunisia.
Banroques J; Expression Génétique Microbienne, UMR8261 CNRS, Université de Paris, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.
Huvelle E; Expression Génétique Microbienne, UMR8261 CNRS, Université de Paris, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.
Oualha R; Laboratory of Molecular Epidemiology and Experimental Pathology (LR16IPT04), Institut Pasteur de Tunis, Université de Tunis El Manar, 13 Place Pasteur, BP74 Tunis-Belvédère 1002, Tunisia.
Yeter-Alat H; Expression Génétique Microbienne, UMR8261 CNRS, Université de Paris, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.
Guizani I; Laboratory of Molecular Epidemiology and Experimental Pathology (LR16IPT04), Institut Pasteur de Tunis, Université de Tunis El Manar, 13 Place Pasteur, BP74 Tunis-Belvédère 1002, Tunisia.
Barhoumi M; Laboratory of Molecular Epidemiology and Experimental Pathology (LR16IPT04), Institut Pasteur de Tunis, Université de Tunis El Manar, 13 Place Pasteur, BP74 Tunis-Belvédère 1002, Tunisia.
Tanner NK; Expression Génétique Microbienne, UMR8261 CNRS, Université de Paris, Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.
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Źródło :
Genes [Genes (Basel)] 2021 Feb 01; Vol. 12 (2). Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD-box RNA Helicases/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Trypanosoma brucei brucei/*genetics
Trypanosomiasis, African/*genetics
Amino Acid Sequence/genetics ; Computer Simulation ; Humans ; Leishmania infantum/genetics ; Leishmania infantum/pathogenicity ; Protein Biosynthesis/genetics ; RNA/genetics ; Saccharomyces cerevisiae/genetics ; Trypanosoma brucei brucei/pathogenicity ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
CEP164C regulates flagellum length in stable flagella.
Autorzy :
Atkins M; Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Týč J; Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Shafiq S; Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Ahmed M; Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Bertiaux E; Trypanosome Cell Biology Unit and Institut National de la Santé et de la Recherche Médicale U1201, Institut Pasteur, Paris, France.; Sorbonne Université école doctorale complexité du vivant, Paris, France.
De Castro Neto AL; Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Sunter J; Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Bastin P; Trypanosome Cell Biology Unit and Institut National de la Santé et de la Recherche Médicale U1201, Institut Pasteur, Paris, France.
Dean SD; Warwick Medical School, University of Warwick, Coventry, UK.
Vaughan S; Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Jan 04; Vol. 220 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flagella/*metabolism
Protozoan Proteins/*metabolism
Trypanosoma brucei brucei/*metabolism
Basal Bodies/metabolism ; Cell Cycle ; Cell Line ; Flagella/ultrastructure ; Gene Knockdown Techniques ; RNA Interference ; Trypanosoma brucei brucei/cytology ; Trypanosoma brucei brucei/ultrastructure
Czasopismo naukowe
Tytuł :
The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei.
Autorzy :
Mochizuki K; Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan; Graduate School of Biomedical Sciences, Nagasaki University, Japan.
Inaoka DK; Department of Molecular Infection Dynamics, Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan; School of Tropical Medicine and Global Health, Nagasaki University, Japan; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Japan. Electronic address: .
Mazet M; Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, France.
Shiba T; Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Japan. Electronic address: .
Fukuda K; Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Japan.
Kurasawa H; Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Japan.
Millerioux Y; Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, France.
Boshart M; Fakultät für Biologie, Genetik, Ludwig-Maximilians-Universität München, Germany.
Balogun EO; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Japan; Department of Biochemistry, Ahmadu Bello University, Nigeria.
Harada S; Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Japan.
Hirayama K; Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.
Bringaud F; Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, France.
Kita K; School of Tropical Medicine and Global Health, Nagasaki University, Japan; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Japan; Department of Host - Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.
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Źródło :
Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2020 Nov 01; Vol. 1861 (11), pp. 148283. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetates/*metabolism
Adenosine Triphosphate/*metabolism
Coenzyme A-Transferases/*metabolism
Mitochondria/*metabolism
Succinate-CoA Ligases/*metabolism
Trypanosoma brucei brucei/*metabolism
Acyl Coenzyme A/metabolism ; Coenzyme A-Transferases/chemistry ; Coenzyme A-Transferases/genetics ; Mutation ; Oxidative Phosphorylation ; Succinate-CoA Ligases/chemistry ; Succinate-CoA Ligases/genetics ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/growth & development
Czasopismo naukowe

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