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Wyszukujesz frazę ""Trypanosomiasis, African"" wg kryterium: Temat


Tytuł :
100 Years of Suramin.
Autorzy :
Wiedemar N; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Hauser DA; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Mäser P; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland .; University of Basel, Basel, Switzerland.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Feb 21; Vol. 64 (3). Date of Electronic Publication: 2020 Feb 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Suramin/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Animals ; Humans ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosoma brucei rhodesiense/pathogenicity ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Activity of Aromathecins against African Trypanosomes.
Autorzy :
Nenortas NP; Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cinelli MA; Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Morrell AE; Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Cushman M; Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Shapiro TA; Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Oct 24; Vol. 62 (11). Date of Electronic Publication: 2018 Oct 24 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiprotozoal Agents/*therapeutic use
Heterocyclic Compounds, 4 or More Rings/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosoma/*drug effects
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Humans ; Structure-Activity Relationship ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Model System Identifies Kinetic Driver of Hsp90 Inhibitor Activity against African Trypanosomes and Plasmodium falciparum.
Autorzy :
Meyer KJ; Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Caton E; Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Shapiro TA; Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA .; The Johns Hopkins Malaria Research Institute, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Jul 27; Vol. 62 (8). Date of Electronic Publication: 2018 Jul 27 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiprotozoal Agents/*pharmacokinetics
HSP90 Heat-Shock Proteins/*antagonists & inhibitors
Malaria, Falciparum/*drug therapy
Plasmodium falciparum/*drug effects
Protozoan Proteins/*antagonists & inhibitors
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Animals ; Antineoplastic Agents/blood ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Antiprotozoal Agents/blood ; Antiprotozoal Agents/pharmacology ; Area Under Curve ; Benzodioxoles/blood ; Benzodioxoles/pharmacokinetics ; Benzodioxoles/pharmacology ; Benzoquinones/blood ; Benzoquinones/pharmacokinetics ; Benzoquinones/pharmacology ; Biological Assay ; Disease Models, Animal ; Drug Repositioning ; Female ; Gene Expression ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; Imidazoles/blood ; Imidazoles/pharmacokinetics ; Imidazoles/pharmacology ; Isoxazoles/blood ; Isoxazoles/pharmacokinetics ; Isoxazoles/pharmacology ; Lactams, Macrocyclic/blood ; Lactams, Macrocyclic/pharmacokinetics ; Lactams, Macrocyclic/pharmacology ; Malaria, Falciparum/parasitology ; Mice ; Models, Biological ; Plasmodium falciparum/growth & development ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Resorcinols/blood ; Resorcinols/pharmacokinetics ; Resorcinols/pharmacology ; Trypanosoma brucei brucei/growth & development ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
In Vitro , Ex Vivo , and In Vivo Activities of Diamidines against Trypanosoma congolense and Trypanosoma vivax.
Autorzy :
Gillingwater K; Parasite Chemotherapy, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland .; University of Basel, Basel, Switzerland.
Kunz C; Parasite Chemotherapy, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Braghiroli C; Parasite Chemotherapy, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Boykin DW; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Tidwell RR; Department of Pathology, University of North Carolina, Chapel Hill, North Carolina, USA.
Brun R; Parasite Chemotherapy, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Apr 24; Vol. 61 (5). Date of Electronic Publication: 2017 Apr 24 (Print Publication: 2017).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cattle Diseases/*drug therapy
Pentamidine/*pharmacology
Trypanosoma congolense/*drug effects
Trypanosoma vivax/*drug effects
Trypanosomiasis, African/*drug therapy
Trypanosomiasis, African/*veterinary
Africa South of the Sahara ; Animals ; Cattle ; Cattle Diseases/parasitology ; Drug Resistance ; Female ; Mice ; Parasitic Sensitivity Tests ; Trypanosomiasis, African/parasitology ; Tsetse Flies/parasitology
Czasopismo naukowe
Tytuł :
Cell Cycle Inhibition To Treat Sleeping Sickness.
Autorzy :
Epting CL; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA .; Department of Pathology, Northwestern University, Chicago, Illinois, USA.
Emmer BT; Department of Pathology, Northwestern University, Chicago, Illinois, USA.; Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA.
Du NY; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA.; Department of Pathology, Northwestern University, Chicago, Illinois, USA.
Taylor JM; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA.; Department of Pathology, Northwestern University, Chicago, Illinois, USA.
Makanji MY; Department of Pediatrics, Northwestern University, Chicago, Illinois, USA.
Olson CL; Department of Pathology, Northwestern University, Chicago, Illinois, USA.
Engman DM; Department of Pathology, Northwestern University, Chicago, Illinois, USA .; Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA.; Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA.
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Źródło :
MBio [mBio] 2017 Sep 19; Vol. 8 (5). Date of Electronic Publication: 2017 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Cycle/*drug effects
Enzyme Inhibitors/*therapeutic use
Hydroxyurea/*therapeutic use
Ribonucleotide Reductases/*antagonists & inhibitors
Trypanocidal Agents/*therapeutic use
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Animals ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Humans ; Hydroxyurea/administration & dosage ; Hydroxyurea/pharmacology ; Mice ; Ribonucleotide Reductases/metabolism ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei brucei/enzymology ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/physiology ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Answer to November 2016 Photo Quiz.
Autorzy :
Hu X; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Sun Y; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xia X; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xu L; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Min B; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Zhou D; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wang L; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wang H; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Niu Z; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
He M; Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wang J; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Deng A; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China .
Yang J; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China .
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Źródło :
Journal of clinical microbiology [J Clin Microbiol] 2016 Nov; Vol. 54 (11), pp. 2843.
Typ publikacji :
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms :
Lethargy/*complications
Lethargy/*etiology
Lymphadenopathy/*complications
Lymphadenopathy/*etiology
Trypanosoma brucei gambiense/*isolation & purification
Trypanosomiasis, African/*diagnosis
Trypanosomiasis, African/*pathology
ADP-ribosyl Cyclase 1/analysis ; Blood/parasitology ; Humans ; Immunohistochemistry ; Lymphadenopathy/pathology ; Male ; Membrane Glycoproteins/analysis ; Microscopy ; Middle Aged ; Polymerase Chain Reaction ; Skin/pathology ; Trypanosomiasis, African/parasitology
Raport
Tytuł :
Photo Quiz: A Man with Lymphadenopathy and Lethargy.
Autorzy :
Hu X; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Sun Y; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xia X; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xu L; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Min B; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Zhou D; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wang L; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wang H; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Niu Z; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
He M; Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wang J; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Deng A; Department of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China .
Yang J; Institute of Hematology, Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China .
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Źródło :
Journal of clinical microbiology [J Clin Microbiol] 2016 Nov; Vol. 54 (11), pp. 2631.
Typ publikacji :
Case Reports; Editorial
MeSH Terms :
Lethargy/*complications
Lethargy/*etiology
Lymphadenopathy/*complications
Lymphadenopathy/*etiology
Trypanosoma brucei gambiense/*isolation & purification
Trypanosomiasis, African/*diagnosis
Trypanosomiasis, African/*pathology
ADP-ribosyl Cyclase 1/analysis ; Blood/parasitology ; Humans ; Immunohistochemistry ; Lymphadenopathy/pathology ; Male ; Membrane Glycoproteins/analysis ; Microscopy ; Middle Aged ; Polymerase Chain Reaction ; Skin/pathology ; Trypanosomiasis, African/parasitology
Raport
Tytuł :
Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection.
Autorzy :
Cuypers B; Biomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium Advanced Database Research and Modelling (ADReM), Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium.
Lecordier L; Laboratory of Molecular Parasitology, Université Libre de Bruxelles, Gosselies, Belgium.
Meehan CJ; Biomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
Van den Broeck F; Biomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
Imamura H; Biomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
Büscher P; Biomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
Dujardin JC; Biomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
Laukens K; Advanced Database Research and Modelling (ADReM), Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium.
Schnaufer A; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Dewar C; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
Lewis M; Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Balmer O; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Azurago T; Disease Control and Prevention Department, Ghana Health Service, Accra, Ghana.
Kyei-Faried S; Disease Control and Prevention Department, Ghana Health Service, Accra, Ghana.
Ohene SA; World Health Organization Country Office in Ghana, Accra, Ghana.
Duah B; Ghana Ports and Harbours Authority Hospital, Takoradi, Ghana.
Homiah P; Ghana Ports and Harbours Authority Hospital, Takoradi, Ghana.
Mensah EK; Public Health Reference Laboratory, Takoradi, Ghana.
Anleah F; Ghana Health Service, Takoradi, Ghana.
Franco JR; Department of Control of Neglected Diseases, World Health Organization, Geneva, Switzerland.
Pays E; Laboratory of Molecular Parasitology, Université Libre de Bruxelles, Gosselies, Belgium.
Deborggraeve S; Biomedical Sciences Department, Institute of Tropical Medicine Antwerp, Antwerp, Belgium .
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Źródło :
MBio [mBio] 2016 Apr 12; Vol. 7 (2), pp. e02198-15. Date of Electronic Publication: 2016 Apr 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility*
Genetic Variation*
Apolipoproteins/*genetics
Lipoproteins, HDL/*genetics
Trypanosoma brucei gambiense/*physiology
Trypanosoma brucei rhodesiense/*physiology
Trypanosomiasis, African/*genetics
Apolipoprotein L1 ; Apolipoproteins/immunology ; Humans ; Immunity, Innate ; Lipoproteins, HDL/immunology ; Mutation, Missense ; Polymorphism, Single Nucleotide ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Trypanosomiasis, African/immunology ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Activity of Bisnaphthalimidopropyl Derivatives against Trypanosoma brucei.
Autorzy :
Graça NA; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IBMC-Institute for Molecular and Cell Biology, Parasite Disease Group, Porto, Portugal.
Gaspar L; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IBMC-Institute for Molecular and Cell Biology, Parasite Disease Group, Porto, Portugal.
Costa DM; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IBMC-Institute for Molecular and Cell Biology, Parasite Disease Group, Porto, Portugal.
Loureiro I; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IBMC-Institute for Molecular and Cell Biology, Parasite Disease Group, Porto, Portugal.
Thoo-Lin PK; Institute for Health & Welfare Research, School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, Scotland, United Kingdom.
Ramos I; Innoprot SL, Derio, Spain.
Roura M; Innoprot SL, Derio, Spain.
Pruvost A; CEA, iBiTec-S, SPI, Laboratoire d'Etude du Métabolisme des Médicaments, Gif sur Yvette, France.
Pemberton IK; Photeomix, IP Research Consulting SAS, Noisy le Grand, France.
Loukil H; Photeomix, IP Research Consulting SAS, Noisy le Grand, France.
MacDougall J; Photeomix, IP Research Consulting SAS, Noisy le Grand, France.
Tavares J; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IBMC-Institute for Molecular and Cell Biology, Parasite Disease Group, Porto, Portugal .
Cordeiro-da-Silva A; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal IBMC-Institute for Molecular and Cell Biology, Parasite Disease Group, Porto, Portugal Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Mar 25; Vol. 60 (4), pp. 2532-6. Date of Electronic Publication: 2016 Mar 25 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Naphthalimides/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Animals ; Cell Line ; Drug Stability ; Female ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Inhibitory Concentration 50 ; Liver/drug effects ; Liver/metabolism ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Mice, Inbred BALB C ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/metabolism ; Naphthalimides/chemical synthesis ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Parasite Load ; Pentamidine/pharmacology ; Primary Cell Culture ; Structure-Activity Relationship ; Survival Analysis ; Trypanocidal Agents/chemical synthesis ; Trypanosoma brucei brucei/growth & development ; Trypanosoma brucei brucei/metabolism ; Trypanosomiasis, African/mortality ; Trypanosomiasis, African/parasitology ; Trypanosomiasis, African/pathology
Czasopismo naukowe
Tytuł :
In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates.
Autorzy :
Yang G; Leishmania Research Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea Interdisciplinary Programs of Functional Genomics, Yonsei University, Seoul, Republic of Korea.
Zhu W; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kim K; Department of System Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Byun SY; Leishmania Research Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Choi G; Leishmania Research Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.
Wang K; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Cha JS; Department of System Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Cho HS; Department of System Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Oldfield E; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA .
No JH; Leishmania Research Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec; Vol. 59 (12), pp. 7530-9. Date of Electronic Publication: 2015 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diphosphonates/*pharmacology
Enzyme Inhibitors/*pharmacology
Geranyltranstransferase/*chemistry
Parasitemia/*drug therapy
Protozoan Proteins/*chemistry
Trypanocidal Agents/*pharmacology
Trypanosomiasis, African/*drug therapy
Animals ; Binding Sites ; Diphosphonates/chemical synthesis ; Diphosphonates/chemistry ; Disease Models, Animal ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Geranyltranstransferase/antagonists & inhibitors ; Geranyltranstransferase/genetics ; Geranyltranstransferase/metabolism ; HEK293 Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Parasitemia/mortality ; Parasitemia/parasitology ; Parasitemia/pathology ; Protein Binding ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Structure-Activity Relationship ; Survival Analysis ; Thermodynamics ; Trypanocidal Agents/chemical synthesis ; Trypanocidal Agents/chemistry ; Trypanosoma brucei brucei/drug effects ; Trypanosoma brucei brucei/enzymology ; Trypanosoma brucei brucei/growth & development ; Trypanosomiasis, African/mortality ; Trypanosomiasis, African/parasitology ; Trypanosomiasis, African/pathology
Czasopismo naukowe
Tytuł :
Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.
Autorzy :
Rodenko B; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom .
Wanner MJ; Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Alkhaldi AA; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom Department of Biology, College of Science, Aljouf University, Skaka, Kingdom of Saudi Arabia.
Ebiloma GU; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Barnes RL; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Kaiser M; Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
Brun R; Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
McCulloch R; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow, United Kingdom.
Koomen GJ; Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands.
de Koning HP; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Nov; Vol. 59 (11), pp. 6708-16. Date of Electronic Publication: 2015 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA, Protozoan/*genetics
Purines/*chemistry
Purines/*therapeutic use
Trypanocidal Agents/*chemistry
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Animals ; Cell Line ; DNA, Protozoan/drug effects ; Female ; Mice ; Trypanosoma brucei brucei/drug effects ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/pathogenicity ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole.
Autorzy :
Watson JA; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand .; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Strub-Wourgraft N; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
Tarral A; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
Ribeiro I; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
Tarning J; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
White NJ; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand .; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Mar 27; Vol. 63 (4). Date of Electronic Publication: 2019 Mar 27 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Marrow/*drug effects
Liver/*drug effects
Nitroimidazoles/*adverse effects
Nitroimidazoles/*pharmacokinetics
Trypanocidal Agents/*adverse effects
Trypanocidal Agents/*pharmacokinetics
Administration, Oral ; Animals ; Bayes Theorem ; Bone Marrow/metabolism ; Chagas Disease/drug therapy ; Chagas Disease/metabolism ; Clinical Trials as Topic ; Disease Models, Animal ; Double-Blind Method ; Humans ; Liver/metabolism ; Male ; Nitroimidazoles/pharmacology ; Randomized Controlled Trials as Topic ; Sulfones/adverse effects ; Sulfones/pharmacokinetics ; Sulfones/pharmacology ; Treatment Outcome ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei gambiense/drug effects ; Trypanosomiasis, African/drug therapy ; Trypanosomiasis, African/metabolism
Czasopismo naukowe
Tytuł :
Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth.
Autorzy :
Efstathiou A; Department of Microbiology, Hellenic Pasteur Institute, Athens, Greece.
Gaboriaud-Kolar N; Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Myrianthopoulos V; Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.; Athena Research and Innovation Center, Athens, Greece.
Vougogiannopoulou K; Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Subota I; Trypanosome Cell Biology Unit, INSERM U1201, Institut Pasteur, Paris, France.
Aicher S; Department of Microbiology, Hellenic Pasteur Institute, Athens, Greece.
Mikros E; Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Bastin P; Trypanosome Cell Biology Unit, INSERM U1201, Institut Pasteur, Paris, France.
Skaltsounis AL; Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Soteriadou K; Department of Microbiology, Hellenic Pasteur Institute, Athens, Greece.
Smirlis D; Department of Microbiology, Hellenic Pasteur Institute, Athens, Greece .
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 May 24; Vol. 63 (6). Date of Electronic Publication: 2019 May 24 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycogen Synthase Kinase 3/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Trypanosoma brucei brucei/*metabolism
Animals ; Cell Line ; Indoles/pharmacology ; Insecta/parasitology ; Structure-Activity Relationship ; Trypanosomiasis, African/drug therapy
Czasopismo naukowe
Tytuł :
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.
Autorzy :
Wenzler T; Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland .
Yang S; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, USA.
Patrick DA; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Braissant O; University of Basel, Basel, Switzerland Department of Urology, University Hospital of Basel, Basel, Switzerland.
Ismail MA; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Tidwell RR; Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Boykin DW; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Wang MZ; Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, Kansas, USA.
Brun R; Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Aug; Vol. 58 (8), pp. 4452-63. Date of Electronic Publication: 2014 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amidines/*pharmacology
Pyridines/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei gambiense/*drug effects
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Amidines/chemical synthesis ; Amidines/pharmacokinetics ; Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Melarsoprol/pharmacokinetics ; Melarsoprol/pharmacology ; Mice ; Pentamidine/pharmacokinetics ; Pentamidine/pharmacology ; Pyridines/chemical synthesis ; Pyridines/pharmacokinetics ; Structure-Activity Relationship ; Trypanocidal Agents/chemical synthesis ; Trypanocidal Agents/pharmacokinetics ; Trypanosoma brucei gambiense/growth & development ; Trypanosoma brucei gambiense/pathogenicity ; Trypanosoma brucei rhodesiense/growth & development ; Trypanosoma brucei rhodesiense/pathogenicity ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response.
Autorzy :
Kafková L; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
Tu C; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.
Pazzo KL; Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA.
Smith KP; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
Debler EW; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Paul KS; Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA.
Qu J; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.
Read LK; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA .
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Źródło :
MBio [mBio] 2018 Dec 18; Vol. 9 (6). Date of Electronic Publication: 2018 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Energy Metabolism*
Protein-Arginine N-Methyltransferases/*metabolism
Protozoan Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Trypanosoma brucei brucei/*metabolism
Animals ; Female ; Gene Knockout Techniques ; Glycolysis ; Methylation ; Mice ; Protein-Arginine N-Methyltransferases/genetics ; Proteomics ; Protozoan Proteins/genetics ; RNA-Binding Proteins/genetics ; Stress, Physiological ; Trypanosoma brucei brucei/pathogenicity ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Novel Observations Concerning Differentiation of Bloodstream-Form Trypanosomes to the Form That Is Adapted for Growth in Tsetse Flies.
Autorzy :
Clayton C; Centre for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany .
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Źródło :
MSphere [mSphere] 2018 Oct 31; Vol. 3 (5). Date of Electronic Publication: 2018 Oct 31.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Trypanosoma brucei brucei*
Tsetse Flies*
Animals ; Cell Differentiation ; Culture Media ; Glucose ; Nutrients ; Protozoan Proteins ; Trypanosoma ; Trypanosomiasis, African
Czasopismo naukowe
Tytuł :
Low-dose intradermal infection with trypanosoma congolense leads to expansion of regulatory T cells and enhanced susceptibility to reinfection.
Autorzy :
Onyilagha C; Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Okwor I
Kuriakose S
Singh R
Uzonna J
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Źródło :
Infection and immunity [Infect Immun] 2014 Mar; Vol. 82 (3), pp. 1074-83. Date of Electronic Publication: 2013 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility/*immunology
T-Lymphocytes, Regulatory/*immunology
Trypanosoma congolense/*immunology
Trypanosomiasis, African/*immunology
Animals ; Antibodies, Monoclonal/immunology ; CD4 Antigens/immunology ; Cells, Cultured ; Disease Susceptibility/parasitology ; Female ; Forkhead Transcription Factors/immunology ; Interferon-gamma/immunology ; Interleukin-2 Receptor alpha Subunit/immunology ; Interleukins/immunology ; Lymph Nodes/immunology ; Lymph Nodes/parasitology ; Mice ; Mice, Inbred BALB C ; Parasitemia/immunology ; Parasitemia/parasitology ; Spleen/immunology ; Spleen/parasitology ; T-Lymphocytes, Regulatory/parasitology ; Transforming Growth Factor beta/immunology ; Trypanosomiasis, African/parasitology ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.
Autorzy :
Wenzler T; Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Yang S
Braissant O
Boykin DW
Brun R
Wang MZ
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Nov; Vol. 57 (11), pp. 5330-43. Date of Electronic Publication: 2013 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amidines/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei gambiense/*drug effects
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Amidines/pharmacokinetics ; Animals ; Drug Administration Schedule ; Drug Evaluation, Preclinical ; Female ; Humans ; Injections, Intraperitoneal ; Melarsoprol/pharmacology ; Mice ; Parasitic Sensitivity Tests ; Pentamidine/pharmacology ; Time Factors ; Trypanocidal Agents/pharmacokinetics ; Trypanosoma brucei gambiense/growth & development ; Trypanosoma brucei rhodesiense/growth & development ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Environmentally regulated glycosome protein composition in the African trypanosome.
Autorzy :
Bauer S; Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, USA.
Morris JC
Morris MT
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Źródło :
Eukaryotic cell [Eukaryot Cell] 2013 Aug; Vol. 12 (8), pp. 1072-9. Date of Electronic Publication: 2013 May 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Microbodies/*metabolism
Protozoan Proteins/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Trypanosoma brucei brucei/*metabolism
Trypanosomiasis, African/*genetics
Animals ; Fluorescent Dyes ; Microbodies/genetics ; Peroxisomal Targeting Signal 2 Receptor ; Peroxisomes/genetics ; Peroxisomes/metabolism ; Receptors, Cytoplasmic and Nuclear/genetics ; Sequence Homology, Amino Acid ; Trypanosoma brucei brucei/pathogenicity ; Trypanosomiasis, African/metabolism
Czasopismo naukowe
Tytuł :
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
Autorzy :
Vodnala SK; Department of Microbiology, Karolinska Institutet, Stockholm, Sweden.
Lundbäck T
Sjöberg B
Svensson R
Rottenberg ME
Hammarström LG
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Feb; Vol. 57 (2), pp. 1012-8. Date of Electronic Publication: 2012 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminopyridines/*pharmacology
Benzopyrans/*pharmacology
Piperidines/*pharmacology
Pyrazines/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosomiasis, African/*drug therapy
Aminopyridines/therapeutic use ; Animals ; Benzopyrans/therapeutic use ; Cell Line ; Humans ; Mice ; Mice, Inbred C57BL ; Piperidines/therapeutic use ; Pyrazines/therapeutic use ; Trypanocidal Agents/therapeutic use ; Trypanosoma brucei brucei/drug effects ; Trypanosoma brucei gambiense/drug effects ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosomiasis, African/parasitology
Czasopismo naukowe

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