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Wyszukujesz frazę ""Trypanosomiasis, African"" wg kryterium: Temat


Tytuł :
Follow-up of dairy cattle naturally infected by Trypanosoma vivax after treatment with isometamidium chloride.
Autorzy :
Castilho Neto KJGA; Faculdade de Ciências Agrárias e Veterinárias - FCAV, Universidade Estadual Paulista - UNESP, Jaboticabal, SP, Brasil.
Garcia ABDCF; Faculdade de Ciências Agrárias e Veterinárias - FCAV, Universidade Estadual Paulista - UNESP, Jaboticabal, SP, Brasil.
Fidelis Junior OL; Departamento de Medicina Veterinária, Universidade de Vila Velha - UVV, Vila Velha, ES, Brasil.
Nagata WB; Escola de Medicina Veterinária Medicine, Universidade Estadual Paulista - UNESP, Araçatuba, SP, Brasil.
André MR; Faculdade de Ciências Agrárias e Veterinárias - FCAV, Universidade Estadual Paulista - UNESP, Jaboticabal, SP, Brasil.
Teixeira MMG; Instituto de Ciências Biomédicas, Universidade de São Paulo - USP, São Paulo, SP, Brasil.
Machado RZ; Faculdade de Ciências Agrárias e Veterinárias - FCAV, Universidade Estadual Paulista - UNESP, Jaboticabal, SP, Brasil.
Cadioli FA; Faculdade de Ciências Agrárias e Veterinárias - FCAV, Universidade Estadual Paulista - UNESP, Jaboticabal, SP, Brasil.; Escola de Medicina Veterinária Medicine, Universidade Estadual Paulista - UNESP, Araçatuba, SP, Brasil.
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Źródło :
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria [Rev Bras Parasitol Vet] 2021 Apr 26; Vol. 30 (1), pp. e020220. Date of Electronic Publication: 2021 Apr 26 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Trypanocidal Agents*/therapeutic use
Trypanosomiasis, African*/veterinary
Trypanosomiasis, Bovine*/diagnosis
Trypanosomiasis, Bovine*/drug therapy
Animals ; Brazil ; Cattle ; Follow-Up Studies ; Molecular Diagnostic Techniques ; Nucleic Acid Amplification Techniques ; Phenanthridines ; Trypanosoma vivax
SCR Protocol :
LAMP assay
Czasopismo naukowe
Tytuł :
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
Autorzy :
Giordani F; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Paape D; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Vincent IM; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Pountain AW; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Fernández-Cortés F; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Rico E; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Zhang N; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Morrison LJ; Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom.
Freund Y; Anacor Pharmaceuticals, Inc., Palo Alto, California, United States of America.
Witty MJ; Global Alliance for Livestock and Veterinary Medicine, Pentlands Science Park, Penicuik, Edinburgh, United Kingdom.
Peter R; Global Alliance for Livestock and Veterinary Medicine, Pentlands Science Park, Penicuik, Edinburgh, United Kingdom.
Edwards DY; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Wilkes JM; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
van der Hooft JJJ; Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Current address: Bioinformatics Group, Wageningen University, Wageningen, the Netherlands.
Regnault C; Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Read KD; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Horn D; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Field MC; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic.
Barrett MP; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.; Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Nov 03; Vol. 16 (11), pp. e1008932. Date of Electronic Publication: 2020 Nov 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Boron Compounds/*metabolism
Carboxypeptidases/*metabolism
Trypanocidal Agents/*metabolism
Trypanosoma brucei brucei/*enzymology
Trypanosoma congolense/*enzymology
Trypanosoma vivax/*enzymology
Trypanosomiasis, African/*veterinary
Valine/*analogs & derivatives
Animals ; Carboxylic Acids/metabolism ; Drug Resistance ; Female ; Livestock ; Mice ; Parasitemia/veterinary ; Prodrugs/metabolism ; Protozoan Proteins/metabolism ; Trypanosoma brucei brucei/drug effects ; Trypanosoma congolense/drug effects ; Trypanosoma vivax/drug effects ; Trypanosomiasis, African/drug therapy ; Trypanosomiasis, African/parasitology ; Valine/metabolism
Czasopismo naukowe
Tytuł :
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Autorzy :
Ndung'u K; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Murilla GA; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; KAG EAST University, Nairobi, Kenya.
Thuita JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; Meru University of Science and Technology, Meru, Kenya.
Ngae GN; Food Crops Research Institute, Kenya Agricultural and Livestock Research Organization, Nairobi, Kenya.
Auma JE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Gitonga PK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Thungu DK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Kurgat RK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Chemuliti JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Mdachi RE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
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Źródło :
PloS one [PLoS One] 2020 Nov 05; Vol. 15 (11), pp. e0229060. Date of Electronic Publication: 2020 Nov 05 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Trypanocidal Agents/*pharmacology
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Virulence/*drug effects
Animals ; Diminazene/analogs & derivatives ; Diminazene/pharmacology ; Disease Models, Animal ; Drug Resistance/drug effects ; Kenya ; Male ; Melarsoprol/pharmacology ; Mice ; Pentamidine/pharmacology ; Suramin/pharmacology ; Treatment Outcome ; Trypanosomiasis, African/parasitology ; Uganda
Czasopismo naukowe
Tytuł :
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines.
Autorzy :
Robinson WJ; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
Taylor AE; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
Lauga-Cami S; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
Weaver GW; Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK.
Arroo RRJ; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
Kaiser M; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland; University of Basel, Petersplatz 1, 4003, Basel, Switzerland.
Gul S; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Hamburg Site, Hamburg, Germany.
Kuzikov M; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Hamburg Site, Hamburg, Germany.
Ellinger B; Fraunhofer Institute for Molecular Biology and Applied Ecology Screening Port, Hamburg, Germany; Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Hamburg Site, Hamburg, Germany.
Singh K; Department of Chemistry, University of Leicester, Leicester, LE1 7RH, UK.
Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University of Mainz, Staudingerweg 5, D-55128, Mainz, Germany.
Botana A; JEOL UK, JEOL House, Silvert Court, Watchmead, Welwyn Garden City, Herts, AL7 1LT, UK.
Eurtivong C; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.
Bhambra AS; Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester, LE1 9BH, UK. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 01; Vol. 209, pp. 112871. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Pyrimidines/*chemistry
Pyrimidines/*pharmacology
Trypanocidal Agents/*chemistry
Trypanocidal Agents/*pharmacology
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Animals ; Cell Line ; Drug Discovery ; Humans ; Models, Molecular ; Rats
Czasopismo naukowe
Tytuł :
Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei.
Autorzy :
Czerwonka D; Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61‒614, Poznań, Poland.
Barcelos Y; Bob Champion Research & Education Building, Norwich Medical School, University of East Anglia, Norwich, UK.
Steverding D; Bob Champion Research & Education Building, Norwich Medical School, University of East Anglia, Norwich, UK.
Cioch A; Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61‒614, Poznań, Poland.
Huczyński A; Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61‒614, Poznań, Poland.
Antoszczak M; Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61‒614, Poznań, Poland. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 01; Vol. 209, pp. 112900. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Pyrans/*chemistry
Pyrans/*pharmacology
Trypanocidal Agents/*chemistry
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Animals ; Cell Line ; Drug Design ; Humans ; Pyrans/chemical synthesis ; Trypanocidal Agents/chemical synthesis ; Trypanosomiasis, African/drug therapy
Czasopismo naukowe
Tytuł :
In vitro and in vivo antitrypanosomal efficacy of combination therapy of Anogeissus leiocarpus, Khaya senegalensis and potash.
Autorzy :
Tauheed AM; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. Electronic address: .
Mamman M; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Ahmed A; Department of Pharmacognosy and Drug Development, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
Suleiman MM; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria; College of Agriculture and Animal Science, Mando, Ahmadu Bello University, Kaduna State, Nigeria.
Balogun EO; Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria; School of Pharmaceutical Sciences, University of California San Diego, United States of America.
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Aug 10; Vol. 258, pp. 112805. Date of Electronic Publication: 2020 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Combretaceae/*chemistry
Complex Mixtures/*chemistry
Meliaceae/*chemistry
Trypanocidal Agents/*administration & dosage
Trypanosomiasis, African/*drug therapy
Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Male ; Mice ; Nigeria ; Parasitemia/drug therapy ; Parasitemia/parasitology ; Plant Extracts/administration & dosage ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Rats ; Rats, Wistar ; Trypanocidal Agents/isolation & purification ; Trypanocidal Agents/pharmacology ; Trypanosoma congolense/drug effects ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Prevalence of trypanosomes associated with drug resistance in Shimba Hills, Kwale County, Kenya.
Autorzy :
Kulohoma BW; Centre for Biotechnology and Bioinformatics, University of Nairobi, P.O. Box 30197, Nairobi, 00100, Kenya. .; International Centre of Insect Physiology and Ecology, Nairobi, Kenya. .
Wamwenje SAO; Centre for Biotechnology and Bioinformatics, University of Nairobi, P.O. Box 30197, Nairobi, 00100, Kenya.; International Centre of Insect Physiology and Ecology, Nairobi, Kenya.
Wangwe II; Centre for Biotechnology and Bioinformatics, University of Nairobi, P.O. Box 30197, Nairobi, 00100, Kenya.; International Centre of Insect Physiology and Ecology, Nairobi, Kenya.
Masila N; Kenya Tsetse and Trypanosomiasis Eradication Council (KENTTEC), Kwale County, Kenya.
Mirieri CK; Directorate of Veterinary Services, Vector Regulatory and Zoological Services, Makindu, Kenya.
Wambua L; International Centre of Insect Physiology and Ecology, Nairobi, Kenya.; School of Biological Sciences, University of Nairobi, Nairobi, Kenya.; International Livestock Research Institute, Nairobi, Kenya.
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Źródło :
BMC research notes [BMC Res Notes] 2020 Apr 29; Vol. 13 (1), pp. 234. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance/*genetics
Nucleoside Transport Proteins/*genetics
Trypanocidal Agents/*therapeutic use
Trypanosoma/*genetics
Trypanosomiasis, African/*epidemiology
Tsetse Flies/*parasitology
Animals ; Female ; Insect Vectors/parasitology ; Kenya ; Male ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Prevalence ; Trypanosoma/isolation & purification ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Molecular identification of diminazene aceturate-resistant strains of Trypanosoma congolense in naturally infected domestic animals of Yoko in the centre region of Cameroon.
Autorzy :
Mewamba EM; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Farikou O; University of Bamenda, Cameroon.
Kamga RMN; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Magang MEK; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Tume C; University of Dschang Faculty of Sciences, Dschang, Cameroon.
Tiofack AAZ; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon.
Ravel S; Institut de Recherche pour le Développement, UMR INTERTRYP, Montpellier, France.
Simo G; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, PO. Box 67, Dschang, Cameroon. Electronic address: .
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Źródło :
Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2020 Apr; Vol. 20, pp. 100405. Date of Electronic Publication: 2020 Mar 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cattle Diseases/*parasitology
Diminazene/*analogs & derivatives
Drug Resistance/*genetics
Sheep Diseases/*parasitology
Trypanocidal Agents/*pharmacology
Trypanosoma congolense/*genetics
Trypanosomiasis, African/*veterinary
Animals ; Cameroon ; Cattle ; Cross-Sectional Studies ; Diminazene/pharmacology ; Sheep ; Sheep, Domestic ; Trypanosoma congolense/drug effects ; Trypanosoma congolense/isolation & purification ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis.
Autorzy :
Hagen JP; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States. Electronic address: .
Darner G; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Anderson S; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Higgins K; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Leas DA; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Mitra A; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Mashinson V; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Wol T; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Vera-Esquivel C; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Belter B; Department of Chemistry, University of Nebraska at Omaha, Omaha, NE 68182-0109, United States.
Cal M; Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
Kaiser M; Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland.
Wallick A; Department of Biology, University of Nebraska at Omaha, Omaha, NE 68182, United States.
Warner RC; Department of Biology, University of Nebraska at Omaha, Omaha, NE 68182, United States.
Davis PH; Department of Biology, University of Nebraska at Omaha, Omaha, NE 68182, United States.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Apr; Vol. 97, pp. 103590. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzylamines/*chemistry
Benzylamines/*pharmacology
Trypanocidal Agents/*chemistry
Trypanocidal Agents/*pharmacology
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Cell Line ; Humans ; Phenyl Ethers/chemistry ; Phenyl Ethers/pharmacology ; Structure-Activity Relationship ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
TrypInDB: A searchable online resource of small molecule inhibitors against Trypanosoma sp.
Autorzy :
Vijayakumar S; Department of Statistics / Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar, 800007, India. Electronic address: .
Ranjan R; Department of Statistics / Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar, 800007, India.
Kumar R; Department of Life sciences, National Institute of Technology, Rourkela, India.
Das P; Department of Molecular Biology, Bioinformatics Centre, Rajendra Memorial Research Institute of Medical Science, Indian Council for Medical Research, Agamkuan, Patna, Bihar 800007, India.
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Źródło :
Parasitology international [Parasitol Int] 2020 Oct; Vol. 78, pp. 102131. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Databases as Topic*
Small Molecule Libraries*
Chagas Disease/*drug therapy
Trypanocidal Agents/*chemistry
Trypanosoma/*drug effects
Trypanosomiasis, African/*drug therapy
Czasopismo naukowe
Tytuł :
In Vitro Drug Efficacy Testing Against Trypanosoma brucei.
Autorzy :
Kaiser M; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Mäser P; Swiss Tropical and Public Health Institute, Basel, Switzerland. .; University of Basel, Basel, Switzerland. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2116, pp. 781-789.
Typ publikacji :
Journal Article
MeSH Terms :
Parasitic Sensitivity Tests/*methods
Trypanocidal Agents/*pharmacology
Trypanosoma/*drug effects
Trypanosomiasis, African/*drug therapy
Calorimetry/methods ; Drug Evaluation, Preclinical/methods ; Humans ; Life Cycle Stages/drug effects ; Nitroimidazoles/pharmacology ; Nitroimidazoles/therapeutic use ; Trypanocidal Agents/therapeutic use ; Trypanosoma/physiology ; Trypanosomiasis, African/blood ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency.
Autorzy :
Franco J; Laboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay; Group Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Scarone L; Laboratorio de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay. Electronic address: .
Comini MA; Group Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Mar 01; Vol. 189, pp. 112043. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle/*drug effects
Distamycins/*chemistry
Macrophages/*drug effects
Thiazoles/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma/*drug effects
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Animals ; Female ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Thiazoles/chemistry ; Trypanocidal Agents/chemistry ; Trypanosoma/parasitology ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
100 Years of Suramin.
Autorzy :
Wiedemar N; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Hauser DA; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Mäser P; Swiss Tropical and Public Health Institute, Department of Medical Parasitology and Infection Biology, Basel, Switzerland .; University of Basel, Basel, Switzerland.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Feb 21; Vol. 64 (3). Date of Electronic Publication: 2020 Feb 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Suramin/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Animals ; Humans ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosoma brucei rhodesiense/pathogenicity ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Prescription of concomitant medications in patients treated with Nifurtimox Eflornithine Combination Therapy (NECT) for T.b. gambiense second stage sleeping sickness in the Democratic Republic of the Congo.
Autorzy :
Kuemmerle A; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Schmid C; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Kande V; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Democratic Republic of the Congo.
Mutombo W; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Democratic Republic of the Congo.; DNDi, Geneva, Switzerland.
Ilunga M; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Democratic Republic of the Congo.
Lumpungu I; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Democratic Republic of the Congo.
Mutanda S; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Democratic Republic of the Congo.
Nganzobo P; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Democratic Republic of the Congo.
Ngolo D; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Democratic Republic of the Congo.; DNDi, Geneva, Switzerland.
Kisala M; Bureau Diocesain d'Oeuvres Medicales, Kikwit, Democratic Republic of the Congo.
Valverde Mordt O; DNDi, Geneva, Switzerland.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jan 27; Vol. 14 (1), pp. e0008028. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma brucei gambiense*
Eflornithine/*therapeutic use
Nifurtimox/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Democratic Republic of the Congo/epidemiology ; Drug Therapy, Combination ; Eflornithine/administration & dosage ; Humans ; Nifurtimox/administration & dosage ; Treatment Outcome ; Trypanosomiasis, African/epidemiology
Czasopismo naukowe
Tytuł :
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- b ]pyridazines for the Treatment of Human African Trypanosomiasis.
Autorzy :
Tear WF; Department of Chemistry & Chemical Biology , Northeastern University , 360 Huntington Avenue , Boston , Massachusetts 02115 , United States.
Bag S; Department of Chemistry & Chemical Biology , Northeastern University , 360 Huntington Avenue , Boston , Massachusetts 02115 , United States.
Diaz-Gonzalez R; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Ceballos-Pérez G; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Rojas-Barros DI; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Cordon-Obras C; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Pérez-Moreno G; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
García-Hernández R; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Martinez-Martinez MS; Tres Cantos Medicines Development Campus, DDW and CIB , GlaxoSmithKline , Tres Cantos 28760 , Spain.
Ruiz-Perez LM; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Gamarro F; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Gonzalez Pacanowska D; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences , University of California San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.
Ferrins L; Department of Chemistry & Chemical Biology , Northeastern University , 360 Huntington Avenue , Boston , Massachusetts 02115 , United States.
Manzano P; Tres Cantos Medicines Development Campus, DDW and CIB , GlaxoSmithKline , Tres Cantos 28760 , Spain.
Navarro M; Instituto de Parasitología y Biomedicina 'López-Neyra', Consejo Superior de Investigaciones Cientificas (CSIC) , Granada 18016 , Spain.
Pollastri MP; Department of Chemistry & Chemical Biology , Northeastern University , 360 Huntington Avenue , Boston , Massachusetts 02115 , United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jan 23; Vol. 63 (2), pp. 756-783. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Pyridazines/*chemical synthesis
Pyridazines/*pharmacology
Trypanocidal Agents/*chemical synthesis
Trypanocidal Agents/*pharmacology
Trypanosomiasis, African/*drug therapy
Animals ; Cell Survival/drug effects ; Crystallography, X-Ray ; Cyclin-Dependent Kinase 2/antagonists & inhibitors ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Drug Repositioning ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; High-Throughput Screening Assays ; Humans ; Leishmania donovani/drug effects ; Mice ; Models, Molecular ; Pyridazines/pharmacokinetics ; Rats ; Structure-Activity Relationship ; Substrate Specificity ; Tissue Distribution ; Trypanocidal Agents/pharmacokinetics ; Trypanosoma brucei brucei/drug effects ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Repositioning of leishmanicidal [1,2,3]Triazolo[1,5-a]pyridinium salts for Chagas disease treatment: Trypanosoma cruzi cell death involving mitochondrial membrane depolarisation and Fe-SOD inhibition.
Autorzy :
Martín-Escolano R; Department of Parasitology, Instituto de Investigación Biosanitaria (ibs. Granada), Hospitales Universitarios de Granada/University of Granada, Severo Ochoa s/n, 18071, Granada, Spain.
Martín-Escolano J; Department of Parasitology, Instituto de Investigación Biosanitaria (ibs. Granada), Hospitales Universitarios de Granada/University of Granada, Severo Ochoa s/n, 18071, Granada, Spain.
Ballesteros-Garrido R; Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Avda. Vicente Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain.
Cirauqui N; Molecular Microbiology and Structural Biochemistry, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, 69367, Lyon Cedex 07, France.
Abarca B; Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Avda. Vicente Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain.
Rosales MJ; Department of Parasitology, Instituto de Investigación Biosanitaria (ibs. Granada), Hospitales Universitarios de Granada/University of Granada, Severo Ochoa s/n, 18071, Granada, Spain.
Sánchez-Moreno M; Department of Parasitology, Instituto de Investigación Biosanitaria (ibs. Granada), Hospitales Universitarios de Granada/University of Granada, Severo Ochoa s/n, 18071, Granada, Spain.
Ballesteros R; Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Avda. Vicente Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain.
Marín C; Department of Parasitology, Instituto de Investigación Biosanitaria (ibs. Granada), Hospitales Universitarios de Granada/University of Granada, Severo Ochoa s/n, 18071, Granada, Spain. .
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Źródło :
Parasitology research [Parasitol Res] 2020 Sep; Vol. 119 (9), pp. 2943-2954. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Chagas Disease/*drug therapy
Pyridinium Compounds/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma cruzi/*drug effects
Animals ; Cell Death/drug effects ; Drug Repositioning ; Humans ; Leishmaniasis/drug therapy ; Mitochondrial Membranes/metabolism ; Oxidative Stress/drug effects ; South America ; Superoxide Dismutase/metabolism ; Trypanosomiasis, African/drug therapy
Czasopismo naukowe
Tytuł :
Comparison of therapeutic efficacy of different drugs against Trypanosoma vivax on experimentally infected cattle.
Autorzy :
Bastos TSA; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Faria AM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
de Assis Cavalcante AS; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
de Carvalho Madrid DM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Zapa DMB; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Nicaretta JE; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Cruvinel LB; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Heller LM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Couto LFM; Centro de Parasitologia Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil.
Soares VE; Universidade Brasil, Campus de Descalvado, São Paulo, SP, Brazil.
Cadioli FA; Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista - Unesp, Araçatuba, SP, Brazil.
Lopes WDZ; Departamento de Biociências e Tecnologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil. Electronic address: .
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Źródło :
Preventive veterinary medicine [Prev Vet Med] 2020 Aug; Vol. 181, pp. 105040. Date of Electronic Publication: 2020 May 30.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Diminazene/*analogs & derivatives
Imidocarb/*analogs & derivatives
Phenanthridines/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma vivax/*drug effects
Trypanosomiasis, African/*prevention & control
Trypanosomiasis, Bovine/*prevention & control
Animals ; Cattle ; Diminazene/pharmacology ; Dose-Response Relationship, Drug ; Imidocarb/pharmacology ; Male
Czasopismo naukowe
Tytuł :
Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.
Autorzy :
Quintana JF; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Bueren-Calabuig J; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Zuccotto F; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
de Koning HP; Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom.
Horn D; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
Field MC; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jul 09; Vol. 14 (7), pp. e0008458. Date of Electronic Publication: 2020 Jul 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance*
Trypanosoma brucei brucei*
Aquaglyceroporins/*metabolism
Trypanocidal Agents/*pharmacology
Trypanosomiasis, African/*parasitology
Amino Acid Sequence ; Animals ; Aquaglyceroporins/chemistry ; Protein Stability
Czasopismo naukowe
Tytuł :
Factors associated with persistence of African animal trypanosomiasis in Lango subregion, northern Uganda.
Autorzy :
Wangoola RM; Coordinating Office for Control of Trypanosomiasis in Uganda, Plot 78 Buganda Road, P.O Box 16345, Kampala, Uganda.
Kevin B; University of Florida, Gainesville, FL, USA.
Acup CA; Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland, EH16 4SB, UK.
Welburn S; Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, The Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland, EH16 4SB, UK.
Waiswa C; Coordinating Office for Control of Trypanosomiasis in Uganda, Plot 78 Buganda Road, P.O Box 16345, Kampala, Uganda.
Bugeza J; National Livestock Resources Research Institute (NaLIRRI), P.O. Box 5704, Wakiso, Uganda. .
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Źródło :
Tropical animal health and production [Trop Anim Health Prod] 2019 Sep; Vol. 51 (7), pp. 2011-2018. Date of Electronic Publication: 2019 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Livestock*
Communicable Disease Control/*methods
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*veterinary
Animals ; Cattle ; Cross-Sectional Studies ; Farms ; Ownership ; Phenanthridines/therapeutic use ; Trypanocidal Agents/supply & distribution ; Trypanosoma ; Trypanosomiasis, African/epidemiology ; Uganda/epidemiology ; Veterinary Drugs/supply & distribution ; Veterinary Drugs/therapeutic use
Czasopismo naukowe
Tytuł :
Trypanostatic activity of geranylacetone: Mitigation of Trypanosoma congolense-associated pathological pertubations and insight into the mechanism of anaemia amelioration using in vitro and in silico models.
Autorzy :
Saad SB; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria; Department of Biochemistry, Yusuf Maitama Sule University, Kano, Nigeria.
Ibrahim MA; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria. Electronic address: .
Jatau ID; Department of Veterinary Parasitology and Entomology, Ahmadu Bello University, Zaria, Nigeria.
Shuaibu MN; Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
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Źródło :
Experimental parasitology [Exp Parasitol] 2019 Jun; Vol. 201, pp. 49-56. Date of Electronic Publication: 2019 Apr 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anemia/*prevention & control
Terpenes/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma congolense/*drug effects
Trypanosomiasis, African/*drug therapy
Anemia/drug therapy ; Anemia/parasitology ; Animals ; Female ; Heart/drug effects ; Heart/parasitology ; Inhibitory Concentration 50 ; Kidney/drug effects ; Kidney/parasitology ; Kidney/pathology ; Liver/drug effects ; Liver/parasitology ; Liver/pathology ; Male ; Neglected Diseases/drug therapy ; Neglected Diseases/parasitology ; Neuraminidase/antagonists & inhibitors ; Neuraminidase/chemistry ; Organ Size/drug effects ; Random Allocation ; Rats ; Rats, Wistar ; Rubiaceae/chemistry ; Spleen/drug effects ; Spleen/parasitology ; Spleen/pathology ; Terpenes/chemistry ; Terpenes/therapeutic use ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/therapeutic use ; Trypanosoma congolense/enzymology ; Trypanosomiasis, African/complications ; Trypanosomiasis, African/parasitology
Czasopismo naukowe

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