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Wyszukujesz frazę ""Trypsin"" wg kryterium: Temat


Tytuł :
Triticum monococcum amylase trypsin inhibitors possess a reduced potential to elicit innate immune response in celiac patients compared to Triticum aestivum.
Autorzy :
Iacomino G; Institute of Food Sciences, CNR, Avellino, Italy.
Rotondi Aufiero V; Institute of Food Sciences, CNR, Avellino, Italy.
Di Stasio L; Institute of Food Sciences, CNR, Avellino, Italy.
Picascia S; Institute of Biochemistry and Cell Biology, CNR, Napoli, Italy; E.L.F.I.D, University 'Federico II' Napoli, Italy.
Iannaccone N; Institute of Food Sciences, CNR, Avellino, Italy.
Giardullo N; Gastroenterology Department, S. G. Moscati Hospital, Avellino, Italy.
Troncone R; Department of Translational Medical Science and E.L.F.I.D, University 'Federico II' Napoli, Italy.
Gianfrani C; Institute of Biochemistry and Cell Biology, CNR, Napoli, Italy; E.L.F.I.D, University 'Federico II' Napoli, Italy.
Mamone G; Institute of Food Sciences, CNR, Avellino, Italy.
Mazzarella G; Institute of Food Sciences, CNR, Avellino, Italy; E.L.F.I.D, University 'Federico II' Napoli, Italy. Electronic address: .
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Źródło :
Food research international (Ottawa, Ont.) [Food Res Int] 2021 Jul; Vol. 145, pp. 110386. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Triticum*/classification
Trypsin Inhibitors*
Celiac Disease/*immunology
Amylases ; Humans ; Proteomics ; Trypsin
Czasopismo naukowe
Tytuł :
Binding loop of sunflower trypsin inhibitor 1 serves as a design motif for proteolysis-resistant antimicrobial peptides.
Autorzy :
Wang C; Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P. R. China.
Shao C; Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P. R. China.
Fang Y; Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P. R. China.
Wang J; Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P. R. China.
Dong N; Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P. R. China. Electronic address: .
Shan A; Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P. R. China. Electronic address: .
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Źródło :
Acta biomaterialia [Acta Biomater] 2021 Apr 01; Vol. 124, pp. 254-269. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Helianthus*/metabolism
Trypsin Inhibitors*
Animals ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/pharmacology ; Mice ; Microbial Sensitivity Tests ; Pore Forming Cytotoxic Proteins ; Proteolysis ; Trypsin/metabolism
Czasopismo naukowe
Tytuł :
Hybrid QconCAT-Based Targeted Absolute and Data-Independent Acquisition-Based Label-Free Quantification Enables In-Depth Proteomic Characterization of Wheat Amylase/Trypsin Inhibitor Extracts.
Autorzy :
Sielaff M; Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Curella V; Institute of Translational Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Neerukonda M; Institute of Translational Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Afzal M; State Plant Breeding Institute, University of Hohenheim, Fruwirthstr. 21, 70599 Stuttgart, Germany.
El Hassouni K; State Plant Breeding Institute, University of Hohenheim, Fruwirthstr. 21, 70599 Stuttgart, Germany.
Distler U; Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Schuppan D; Institute of Translational Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, United States.
Longin CFH; State Plant Breeding Institute, University of Hohenheim, Fruwirthstr. 21, 70599 Stuttgart, Germany.
Tenzer S; Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
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Źródło :
Journal of proteome research [J Proteome Res] 2021 Mar 05; Vol. 20 (3), pp. 1544-1557. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Triticum*/genetics
Trypsin Inhibitors*
Amylases ; Plant Breeding ; Plant Extracts ; Proteomics ; Reproducibility of Results ; Trypsin
Czasopismo naukowe
Tytuł :
Statistical analysis of intermolecular interactions in trypsin-inhibitor complexes.
Autorzy :
Gartia J; Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad, India.
Barnwal RP; Department of Biophysics, Panjab University, Chandigarh, India.
Chary KVR; Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad, India.; Department of Chemical Sciences, Indian Institute of Science Education and Research Berhampur, Berhampur, Odisha, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2020 Oct; Vol. 38 (17), pp. 5287-5292. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Letter
MeSH Terms :
Trypsin Inhibitors*
Trypsin
Opinia redakcyjna
Tytuł :
Inhibitory effect of lignin from Canna edulis Ker residues on trypsin: kinetics and molecular docking studies.
Autorzy :
Xie F; Shanghai Engineering Research Center of Food Microbiology, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Zhang W; Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Gong S; Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Wang Z; Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
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Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2021 Mar 30; Vol. 101 (5), pp. 2090-2099. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Glycoside Hydrolase Inhibitors/*chemistry
Lignin/*chemistry
Plant Extracts/*chemistry
Trypsin Inhibitors/*chemistry
Zingiberales/*chemistry
Binding Sites ; Kinetics ; Molecular Docking Simulation ; Thermodynamics ; Trypsin/chemistry ; alpha-Amylases ; alpha-Glucosidases/chemistry
Czasopismo naukowe
Tytuł :
The Effects of Trypsin Inhibitor on Insulin Secretion Using Rat Pancreas in an Organ Bath.
Autorzy :
Morita A; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Ouchi M; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan; .
Satoh K; Department of Pharmacology, Meikai University School of Dentistry, Saitama, Japan.
Kobayashi S; Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Terada M; Dokkyo Medical University School of Medicine, Tochigi, Japan.
Wakashin H; Department of Regulatory Physiology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Kon H; Research Center for Laboratory Animals, Dokkyo Medical University, Tochigi, Japan.
Hayashi K; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Anzai N; Dokkyo Medical University School of Medicine, Tochigi, Japan.; Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan.
Shimizu A; Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
Sugihara H; Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Oba K; Kawaguchi Sakura Clinic, Saitama, Japan.
Fujita T; Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
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Źródło :
In vivo (Athens, Greece) [In Vivo] 2021 Sep-Oct; Vol. 35 (5), pp. 2551-2558.
Typ publikacji :
Journal Article
MeSH Terms :
Amylases*
Trypsin Inhibitors*/metabolism
Trypsin Inhibitors*/pharmacology
Animals ; Insulin/metabolism ; Insulin Secretion ; Male ; Pancreas/metabolism ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Mechanism of low-frequency and high-frequency ultrasound-induced inactivation of soy trypsin inhibitors.
Autorzy :
Wu Y; Sonochemistry Group, School of Chemistry, The University of Melbourne, Parkville, Victoria 3010, Australia.
Li W; Sonochemistry Group, School of Chemistry, The University of Melbourne, Parkville, Victoria 3010, Australia.
Martin GJO; Algal Processing Group, Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: .
Ashokkumar M; Algal Processing Group, Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Oct 30; Vol. 360, pp. 130057. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Sonication*
Plant Proteins/*chemistry
Soybeans/*metabolism
Trypsin Inhibitors/*chemistry
Catalytic Domain ; Kinetics ; Particle Size ; Plant Proteins/metabolism ; Trypsin Inhibitors/metabolism
Czasopismo naukowe
Tytuł :
Trypsin inhibitor content and activity of soaking water whey as waste in soy milk processing.
Autorzy :
Stanojevic SP; Faculty of Agriculture, Department of Chemistry and Biochemistry, Institute of Food Technology and Biochemistry, University of Belgrade, Belgrade, Serbia.
Barać MB; Faculty of Agriculture, Department of Chemistry and Biochemistry, Institute of Food Technology and Biochemistry, University of Belgrade, Belgrade, Serbia.
Kostić AŽ; Faculty of Agriculture, Department of Chemistry and Biochemistry, Institute of Food Technology and Biochemistry, University of Belgrade, Belgrade, Serbia.
Pešić MB; Faculty of Agriculture, Department of Chemistry and Biochemistry, Institute of Food Technology and Biochemistry, University of Belgrade, Belgrade, Serbia.
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Źródło :
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes [J Environ Sci Health B] 2021; Vol. 56 (3), pp. 292-296. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Soy Milk*
Food-Processing Industry/*methods
Soybeans/*chemistry
Trypsin Inhibitors/*analysis
Aprotinin/isolation & purification ; Trypsin Inhibitor, Bowman-Birk Soybean/analysis ; Trypsin Inhibitor, Bowman-Birk Soybean/isolation & purification ; Trypsin Inhibitor, Bowman-Birk Soybean/metabolism ; Trypsin Inhibitors/isolation & purification ; Trypsin Inhibitors/metabolism ; Waste Products ; Water
Czasopismo naukowe
Tytuł :
Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L.
Autorzy :
de Medeiros AF; Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
de Souza BBP; Postgraduate Biological Molecular, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.; Laboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil.
Coutinho LP; Chemistry Course, Science Center, Federal University of Ceará, Fortaleza, Brazil.
Murad AM; Laboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil.
Dos Santos PIM; Federal Institute of Education, Science and Technology of Rio Grande do Norte, Brazil.
Monteiro NKV; Analytical Chemistry and physical Chemistry Department, Science Center, Federal University of Ceará, Fortaleza, Brazil.
Santos EAD; Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Biochemistry, Biosciences Center, Federal University of Rio Grande, Natal, Brazil.; Tropical Medicine Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Maciel BLL; Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
de Araújo Morais AH; Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.; Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 480-490.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Plant Extracts/*pharmacology
Tamarindus/*chemistry
Trypsin/*metabolism
Trypsin Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Seeds/chemistry ; Structure-Activity Relationship ; Trypsin Inhibitors/chemistry ; Trypsin Inhibitors/isolation & purification
Czasopismo naukowe
Tytuł :
Targeted inactivation of soybean proteinase inhibitors using zinc.
Autorzy :
Rehder A; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Sørensen JC; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Markedal KE; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Sørensen H; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Sørensen S; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Petersen IL; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jul 01; Vol. 349, pp. 129049. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Trypsin Inhibitor, Bowman-Birk Soybean/*metabolism
Trypsin Inhibitor, Kunitz Soybean/*metabolism
Zinc/*pharmacology
Disulfides/chemistry ; Enzyme Activation/drug effects ; Trypsin Inhibitor, Bowman-Birk Soybean/chemistry ; Trypsin Inhibitor, Kunitz Soybean/chemistry
Czasopismo naukowe
Tytuł :
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Autorzy :
Shopit A; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China.
Li X; Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Wang S; School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, China.
Awsh M; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China.
Safi M; Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Chu P; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China.
Jia J; Department of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Al-Radhi M; Department of Urology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Baldi S; Clinical Diagnostic Laboratory Department, Dalian Medical University, Dalian, China.
Wang F; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China.
Fang J; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China.
Peng J; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China.
Ma X; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China.
Tang Z; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China. Electronic address: .
Shu X; Academic Integrated Medicine & Collage of Pharmacy, School of Pharmacy, Department of Pharmacology, Dalian Medical University, Dalian, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Oct; Vol. 91, pp. 153711. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs*/genetics
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/genetics
Trypsin Inhibitor, Kazal Pancreatic*/genetics
Antimetabolites, Antineoplastic/*pharmacology
Deoxycytidine/*analogs & derivatives
Oleanolic Acid/*pharmacology
Cell Line, Tumor ; Deoxycytidine/pharmacology ; Drug Resistance, Neoplasm ; Humans ; Oleanolic Acid/analogs & derivatives
Czasopismo naukowe
Tytuł :
Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis.
Autorzy :
Shan RF; Department of Emergency, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Zhu YA
Qin J
Chen JP
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Sep 24; Vol. 100 (38), pp. e27151.
Typ publikacji :
Journal Article; Meta-Analysis
MeSH Terms :
Drugs, Chinese Herbal/*therapeutic use
Glycoproteins/*therapeutic use
Sepsis/*drug therapy
Trypsin Inhibitors/*therapeutic use
Drugs, Chinese Herbal/administration & dosage ; Glycoproteins/administration & dosage ; Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Trypsin Inhibitors/administration & dosage
Czasopismo naukowe
Tytuł :
High SPINK1 Expression Predicts Poor Prognosis and Promotes Cell Proliferation and Metastasis of Hepatocellular Carcinoma.
Autorzy :
Huang K; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xie W; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Wang S; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Li Q; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Wei X; Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chen B; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Hua Y; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Li S; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Peng B; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Shen S; Department of Hepatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
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Źródło :
Journal of investigative surgery : the official journal of the Academy of Surgical Research [J Invest Surg] 2021 Sep; Vol. 34 (9), pp. 1011-1020. Date of Electronic Publication: 2020 Feb 17.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
Trypsin Inhibitor, Kazal Pancreatic*/genetics
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Humans ; Prognosis
Czasopismo naukowe
Tytuł :
Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid.
Autorzy :
Wicke N; Department of Biochemistry, University of Oxford, Oxford, UK.
Bedford MR; AB Vista, Woodstock Court, Marlborough, UK.
Howarth M; Department of Biochemistry, University of Oxford, Oxford, UK. .
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Źródło :
Communications biology [Commun Biol] 2021 Aug 11; Vol. 4 (1), pp. 960. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*pharmacology
Biomimetic Materials/*chemistry
Clostridioides difficile/*physiology
Hydrochloric Acid/*pharmacology
Pepsin A/*pharmacology
Trypsin Inhibitor, Kunitz Soybean/*chemistry
Animals ; Antibodies/chemistry ; Biomimetic Materials/pharmacology ; Chickens ; Female ; Mice ; Mice, Inbred BALB C ; Trypsin Inhibitor, Kunitz Soybean/pharmacology
Czasopismo naukowe
Tytuł :
Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Autorzy :
Stewart JA; Department of Cardiology, Helsinki University Hospital, Helsinki, Finland.
Koistinen R; Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Lempiäinen A; Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hotakainen K; Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Salminen US; Department of Cardiac Surgery, Helsinki University Hospital, Helsinki, Finland.
Vakkuri A; Department of Anesthesiology and Intensive Care, Helsinki University Hospital, Helsinki, Finland.
Wennervirta J; Department of Anesthesiology and Intensive Care, Helsinki University Hospital, Helsinki, Finland.
Stenman UH; Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Koistinen H; Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
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Źródło :
Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2020 Dec; Vol. 80 (8), pp. 640-643. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Aneurysm, Dissecting/*blood
Aortic Aneurysm/*blood
Cardiopulmonary Bypass/*adverse effects
Chorionic Gonadotropin, beta Subunit, Human/*blood
Circulatory Arrest, Deep Hypothermia Induced/*adverse effects
Trypsin Inhibitor, Kazal Pancreatic/*blood
Adult ; Aged ; Aneurysm, Dissecting/pathology ; Aneurysm, Dissecting/surgery ; Aorta/pathology ; Aorta/surgery ; Aortic Aneurysm/pathology ; Aortic Aneurysm/surgery ; Biomarkers/blood ; Cardiopulmonary Bypass/methods ; Cerebrovascular Circulation ; Circulatory Arrest, Deep Hypothermia Induced/methods ; Critical Illness ; Female ; Humans ; Immunoassay ; Male ; Middle Aged ; Perfusion/methods ; Prospective Studies ; Trypsin/blood ; Trypsinogen/blood
Czasopismo naukowe
Tytuł :
Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome.
Autorzy :
Zhang X; Discovery Chemistry, Janssen Research and Development, LLC, Spring House, PA, United States. Electronic address: .
Zhu B; Discovery Chemistry, Janssen Research and Development, LLC, Spring House, PA, United States.
Sun W; DPDS Molecular & Cellular Pharmacology, Janssen Research and Development, LLC, Spring House, PA, United States.
Wang M; DPDS Molecular & Cellular Pharmacology, Janssen Research and Development, LLC, Spring House, PA, United States.
Albarazanji K; CVM Discovery, Janssen Research and Development, LLC, Spring House, PA, United States.
Ghosh B; Discovery Chemistry, Janssen Research and Development, LLC, Spring House, PA, United States.
Cummings M; Discovery Chemistry, Janssen Research and Development, LLC, Spring House, PA, United States.
Lenhard J; CVM Discovery, Janssen Research and Development, LLC, Spring House, PA, United States.
Leonard J; CVM Discovery, Janssen Research and Development, LLC, Spring House, PA, United States.
Macielag M; Discovery Chemistry, Janssen Research and Development, LLC, Spring House, PA, United States.
Lanter J; Discovery Chemistry, Janssen Research and Development, LLC, Spring House, PA, United States.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 15; Vol. 40, pp. 127939. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoates/*pharmacology
Enteropeptidase/*antagonists & inhibitors
Guanidines/*pharmacology
Trypsin Inhibitors/*pharmacology
Animals ; Benzoates/chemical synthesis ; Benzoates/pharmacokinetics ; CHO Cells ; Cattle ; Cricetulus ; Diet, High-Fat ; Feces/chemistry ; Guanidines/chemical synthesis ; Guanidines/pharmacokinetics ; Humans ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/enzymology ; Mice, Inbred C57BL ; Molecular Structure ; Obesity/drug therapy ; Obesity/enzymology ; Proteins/metabolism ; Structure-Activity Relationship ; Trypsin Inhibitors/chemical synthesis ; Trypsin Inhibitors/pharmacokinetics
Czasopismo naukowe
Tytuł :
Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability.
Autorzy :
Shi JY; Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China.
Pan HY; Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China. Electronic address: .
Liu K; Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China.
Pan M; Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, China.
Si GJ; Department of Cardiology, Nantong Third People's Hospital, Nantong, Jiangsu, 226001, China.
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Sep 15; Vol. 690, pp. 108460. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*metabolism
Matrix Metalloproteinase 9/*metabolism
Plaque, Atherosclerotic/*chemistry
Trypsin/*metabolism
Animals ; Aorta/chemistry ; Aprotinin/administration & dosage ; Aprotinin/metabolism ; Carotid Intima-Media Thickness ; Cytokines/metabolism ; Gene Expression Regulation ; Humans ; Male ; Rabbits ; Receptor, PAR-2/metabolism ; Trypsin/genetics ; Trypsin Inhibitors/administration & dosage ; Trypsin Inhibitors/metabolism
Czasopismo naukowe
Tytuł :
A Study of the Interaction, Morphology, and Structure in Trypsin-Epigallocatechin-3-Gallate Complexes.
Autorzy :
Liu J; College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China.; College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, China.
Ghanizadeh H; School of Agriculture and Environment, Massey University, 4410 Palmerston North, New Zealand.
Li X; College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China.
Han Z; College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China.
Qiu Y; College of Life Sciences, Northeast Agricultural University, Harbin 150030, China.
Zhang Y; College of Life Sciences, Northeast Agricultural University, Harbin 150030, China.
Chen X; College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China.
Wang A; College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China.; College of Life Sciences, Northeast Agricultural University, Harbin 150030, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 28; Vol. 26 (15). Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Aggregates*
Catechin/*analogs & derivatives
Trypsin/*chemistry
Catechin/chemistry ; Catechin/metabolism ; Humans ; Microscopy, Atomic Force ; Models, Molecular ; Protein Conformation ; Solutions ; Spectrometry, Fluorescence ; Trypsin/metabolism
Czasopismo naukowe
Tytuł :
Systematic review and meta-analysis of the efficacy of trypsin inhibitors in patients with severe pancreatitis.
Autorzy :
Zhang J; Department of Gastroenterology, Shanxi Provincial People's Hospital, Taiyuan, China.
Niu L; School of Basic Medical Science, Shanxi Medical University, Taiyuan, China.
Yang Y; Department of Gastroenterology, Shanxi Provincial People's Hospital, Taiyuan, China.
Hao Y; Department of Gastroenterology, Shanxi Provincial People's Hospital, Taiyuan, China.
Feng J; Department of Gastroenterology, Shanxi Provincial People's Hospital, Taiyuan, China.
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Źródło :
Annals of palliative medicine [Ann Palliat Med] 2021 Jun; Vol. 10 (6), pp. 6577-6587. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Pancreatitis*
Trypsin Inhibitors*/therapeutic use
Humans ; Length of Stay
Czasopismo naukowe
Tytuł :
Complement component factor B has thrombin-like activity.
Autorzy :
Takahashi K; Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, United States. Electronic address: .
Banda NK; Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, United States.
Holers VM; Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, United States.
Van Cott EM; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, United States.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 07; Vol. 552, pp. 17-22. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Complement Factor B/*genetics
Thrombin/*genetics
Trypsin/*genetics
Amino Acid Sequence ; Animals ; Binding Sites/genetics ; Complement Factor B/classification ; Complement Factor B/metabolism ; Genetic Variation ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Phylogeny ; Sequence Homology, Amino Acid ; Thrombin/metabolism ; Trypsin/metabolism
Czasopismo naukowe

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